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UniProtKB - Q15750 (TAB1_HUMAN)
Protein
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Gene
TAB1
Organism
Homo sapiens (Human)
Status
Functioni
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Caution
Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 484 | Required for interaction with MAP3K71 Publication | 1 |
GO - Molecular functioni
- enzyme activator activity Source: ProtInc
- kinase activator activity Source: Ensembl
- mitogen-activated protein kinase p38 binding Source: Ensembl
- phosphatase activity Source: InterPro
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- aorta development Source: Ensembl
- cardiac septum development Source: Ensembl
- coronary vasculature development Source: Ensembl
- heart morphogenesis Source: Ensembl
- in utero embryonic development Source: Ensembl
- lung development Source: Ensembl
- positive regulation of MAP kinase activity Source: Ensembl
- positive regulation of protein serine/threonine kinase activity Source: UniProtKB
- transforming growth factor beta receptor signaling pathway Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q15750 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302, activated TAK1 mediates p38 MAPK activation R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5689880, Ub-specific processing proteases R-HSA-9014325, TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9020702, Interleukin-1 signaling R-HSA-937042, IRAK2 mediated activation of TAK1 complex R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-9645460, Alpha-protein kinase 1 signaling pathway R-HSA-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
SignaLinki | Q15750 |
SIGNORi | Q15750 |
Protein family/group databases
MoonDBi | Q15750, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Alternative name(s): Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 TGF-beta-activated kinase 1-binding protein 1 Short name: TAK1-binding protein 1 |
Gene namesi | Name:TAB1 Synonyms:MAP3K7IP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18157, TAB1 |
MIMi | 602615, gene |
neXtProti | NX_Q15750 |
VEuPathDBi | HostDB:ENSG00000100324 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Endosome
- endosome membrane Source: Reactome
Nucleus
- nuclear speck Source: HPA
- nucleus Source: GO_Central
Other locations
- protein-containing complex Source: Ensembl
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 213 | D → A: Loss of interaction with XIAP. 1 Publication | 1 | |
Mutagenesisi | 216 | F → A: Loss of interaction with XIAP. 1 Publication | 1 | |
Mutagenesisi | 438 | S → A: Loss of phosphorylation site. 1 Publication | 1 | |
Mutagenesisi | 484 | F → A: Abolishes interaction with MAP3K7. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 10454 |
OpenTargetsi | ENSG00000100324 |
PharmGKBi | PA30604 |
Miscellaneous databases
Pharosi | Q15750, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5605 |
DrugBanki | DB06757, Manganese |
Genetic variation databases
BioMutai | TAB1 |
DMDMi | 10720303 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057797 | 1 – 504 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Add BLAST | 504 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | PhosphoserineCombined sources | 1 | |
Modified residuei | 378 | PhosphoserineCombined sources | 1 | |
Modified residuei | 438 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 442 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-906 CPTAC-907 |
EPDi | Q15750 |
jPOSTi | Q15750 |
MassIVEi | Q15750 |
MaxQBi | Q15750 |
PaxDbi | Q15750 |
PeptideAtlasi | Q15750 |
PRIDEi | Q15750 |
ProteomicsDBi | 60741 [Q15750-1] 60742 [Q15750-2] |
PTM databases
DEPODi | TAB1 |
GlyGeni | Q15750, 10 sites, 2 O-linked glycans (10 sites) |
iPTMneti | Q15750 |
PhosphoSitePlusi | Q15750 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000100324, Expressed in sural nerve and 201 other tissues |
ExpressionAtlasi | Q15750, baseline and differential |
Genevisiblei | Q15750, HS |
Organism-specific databases
HPAi | ENSG00000100324, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Q15750
GO - Molecular functioni
- mitogen-activated protein kinase p38 binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 115717, 216 interactors |
CORUMi | Q15750 |
DIPi | DIP-27524N |
ELMi | Q15750 |
IntActi | Q15750, 129 interactors |
MINTi | Q15750 |
STRINGi | 9606.ENSP00000216160 |
Chemistry databases
BindingDBi | Q15750 |
Miscellaneous databases
RNActi | Q15750, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q15750 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15750 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 365 | PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST | 338 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 430 – 478 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 430 – 462 | Polar residuesSequence analysisAdd BLAST | 33 |
Phylogenomic databases
eggNOGi | KOG0698, Eukaryota |
GeneTreei | ENSGT00510000048276 |
HOGENOMi | CLU_027717_1_0_1 |
InParanoidi | Q15750 |
OMAi | NTRCLGN |
PhylomeDBi | Q15750 |
TreeFami | TF317785 |
Family and domain databases
CDDi | cd00143, PP2Cc, 1 hit |
Gene3Di | 3.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015655, PP2C IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 1 hit |
Pfami | View protein in Pfam PF00481, PP2C, 1 hit |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS51746, PPM_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q15750-1) [UniParc]FASTAAdd to basket
Also known as: TAB1alpha
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
60 70 80 90 100
DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA
110 120 130 140 150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK
160 170 180 190 200
ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV
210 220 230 240 250
TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY
260 270 280 290 300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH
310 320 330 340 350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR
360 370 380 390 400
FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST
410 420 430 440 450
SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT
460 470 480 490 500
QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV
VTAP
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039271 | 224 | D → E. Corresponds to variant dbSNP:rs17001096Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042024 | 436 – 504 | NQSPT…VVTAP → KDPSRPASDLTAIPQCQLNL LGSLTPG in isoform 2. 1 PublicationAdd BLAST | 69 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U49928 mRNA Translation: AAC12660.1 AF425640 mRNA Translation: AAN32760.1 DQ314876 Genomic DNA Translation: ABC40735.1 AL022312 Genomic DNA No translation available. Z83845 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60326.1 BC050554 mRNA Translation: AAH50554.1 |
CCDSi | CCDS13992.1 [Q15750-2] CCDS13993.1 [Q15750-1] |
RefSeqi | NP_006107.1, NM_006116.2 [Q15750-1] NP_705717.1, NM_153497.2 [Q15750-2] |
Genome annotation databases
Ensembli | ENST00000216160; ENSP00000216160; ENSG00000100324 ENST00000331454; ENSP00000333049; ENSG00000100324 [Q15750-2] |
GeneIDi | 10454 |
KEGGi | hsa:10454 |
MANE-Selecti | ENST00000216160.11; ENSP00000216160.6; NM_006116.3; NP_006107.1 |
UCSCi | uc003axt.4, human [Q15750-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U49928 mRNA Translation: AAC12660.1 AF425640 mRNA Translation: AAN32760.1 DQ314876 Genomic DNA Translation: ABC40735.1 AL022312 Genomic DNA No translation available. Z83845 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60326.1 BC050554 mRNA Translation: AAH50554.1 |
CCDSi | CCDS13992.1 [Q15750-2] CCDS13993.1 [Q15750-1] |
RefSeqi | NP_006107.1, NM_006116.2 [Q15750-1] NP_705717.1, NM_153497.2 [Q15750-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2J4O | X-ray | 2.25 | A | 1-401 | [»] | |
2POM | X-ray | 2.27 | A | 1-370 | [»] | |
2POP | X-ray | 3.10 | A/C | 1-370 | [»] | |
2YDS | X-ray | 2.55 | T | 392-398 | [»] | |
2YIY | X-ray | 2.49 | A | 468-497 | [»] | |
4AY5 | X-ray | 3.15 | I/J/K/L | 389-399 | [»] | |
4AY6 | X-ray | 3.30 | E/F/G/H | 389-401 | [»] | |
4GS6 | X-ray | 2.20 | A | 468-504 | [»] | |
4KA3 | X-ray | 2.71 | B | 395-415 | [»] | |
4L3P | X-ray | 2.68 | A | 468-504 | [»] | |
4L52 | X-ray | 2.54 | A | 468-496 | [»] | |
4L53 | X-ray | 2.55 | A | 468-496 | [»] | |
4O91 | X-ray | 2.39 | A | 468-504 | [»] | |
5DIY | X-ray | 2.06 | P/Q | 392-398 | [»] | |
5E7R | X-ray | 2.11 | A | 468-504 | [»] | |
5GJD | X-ray | 2.79 | A | 468-504 | [»] | |
5GJF | X-ray | 2.89 | A | 468-504 | [»] | |
5GJG | X-ray | 2.61 | A | 468-504 | [»] | |
5J7S | X-ray | 2.37 | A | 468-504 | [»] | |
5J8I | X-ray | 2.40 | A | 468-504 | [»] | |
5J9L | X-ray | 2.75 | A | 468-497 | [»] | |
5JGA | X-ray | 2.00 | A | 468-504 | [»] | |
5JGB | X-ray | 2.80 | A | 468-504 | [»] | |
5JGD | X-ray | 3.10 | A | 468-504 | [»] | |
5JH6 | X-ray | 2.37 | A | 468-504 | [»] | |
5JK3 | X-ray | 2.37 | A | 468-504 | [»] | |
5NZZ | X-ray | 2.60 | A/B/C/D | 1-504 | [»] | |
5O90 | X-ray | 2.49 | B | 386-414 | [»] | |
5V5N | X-ray | 2.01 | A | 468-497 | [»] | |
5VVU | X-ray | 2.70 | B/D | 392-398 | [»] | |
7NTH | X-ray | 1.97 | A | 468-504 | [»] | |
7NTI | X-ray | 1.98 | A | 468-504 | [»] | |
SMRi | Q15750 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115717, 216 interactors |
CORUMi | Q15750 |
DIPi | DIP-27524N |
ELMi | Q15750 |
IntActi | Q15750, 129 interactors |
MINTi | Q15750 |
STRINGi | 9606.ENSP00000216160 |
Chemistry databases
BindingDBi | Q15750 |
ChEMBLi | CHEMBL5605 |
DrugBanki | DB06757, Manganese |
Protein family/group databases
MoonDBi | Q15750, Predicted |
PTM databases
DEPODi | TAB1 |
GlyGeni | Q15750, 10 sites, 2 O-linked glycans (10 sites) |
iPTMneti | Q15750 |
PhosphoSitePlusi | Q15750 |
Genetic variation databases
BioMutai | TAB1 |
DMDMi | 10720303 |
Proteomic databases
CPTACi | CPTAC-906 CPTAC-907 |
EPDi | Q15750 |
jPOSTi | Q15750 |
MassIVEi | Q15750 |
MaxQBi | Q15750 |
PaxDbi | Q15750 |
PeptideAtlasi | Q15750 |
PRIDEi | Q15750 |
ProteomicsDBi | 60741 [Q15750-1] 60742 [Q15750-2] |
Protocols and materials databases
Antibodypediai | 12659, 633 antibodies from 44 providers |
DNASUi | 10454 |
Genome annotation databases
Ensembli | ENST00000216160; ENSP00000216160; ENSG00000100324 ENST00000331454; ENSP00000333049; ENSG00000100324 [Q15750-2] |
GeneIDi | 10454 |
KEGGi | hsa:10454 |
MANE-Selecti | ENST00000216160.11; ENSP00000216160.6; NM_006116.3; NP_006107.1 |
UCSCi | uc003axt.4, human [Q15750-1] |
Organism-specific databases
CTDi | 10454 |
DisGeNETi | 10454 |
GeneCardsi | TAB1 |
HGNCi | HGNC:18157, TAB1 |
HPAi | ENSG00000100324, Low tissue specificity |
MIMi | 602615, gene |
neXtProti | NX_Q15750 |
OpenTargetsi | ENSG00000100324 |
PharmGKBi | PA30604 |
VEuPathDBi | HostDB:ENSG00000100324 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0698, Eukaryota |
GeneTreei | ENSGT00510000048276 |
HOGENOMi | CLU_027717_1_0_1 |
InParanoidi | Q15750 |
OMAi | NTRCLGN |
PhylomeDBi | Q15750 |
TreeFami | TF317785 |
Enzyme and pathway databases
PathwayCommonsi | Q15750 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302, activated TAK1 mediates p38 MAPK activation R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5689880, Ub-specific processing proteases R-HSA-9014325, TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9020702, Interleukin-1 signaling R-HSA-937042, IRAK2 mediated activation of TAK1 complex R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-9645460, Alpha-protein kinase 1 signaling pathway R-HSA-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
SignaLinki | Q15750 |
SIGNORi | Q15750 |
Miscellaneous databases
BioGRID-ORCSi | 10454, 6 hits in 1046 CRISPR screens |
ChiTaRSi | TAB1, human |
EvolutionaryTracei | Q15750 |
GeneWikii | MAP3K7IP1 |
GenomeRNAii | 10454 |
Pharosi | Q15750, Tchem |
PROi | PR:Q15750 |
RNActi | Q15750, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100324, Expressed in sural nerve and 201 other tissues |
ExpressionAtlasi | Q15750, baseline and differential |
Genevisiblei | Q15750, HS |
Family and domain databases
CDDi | cd00143, PP2Cc, 1 hit |
Gene3Di | 3.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015655, PP2C IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 1 hit |
Pfami | View protein in Pfam PF00481, PP2C, 1 hit |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS51746, PPM_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TAB1_HUMAN | |
Accessioni | Q15750Primary (citable) accession number: Q15750 Secondary accession number(s): Q2PP09, Q8IZW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 206 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references