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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene

TAB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Caution

Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei484Required for interaction with MAP3K71 Publication1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-450302 activated TAK1 mediates p38 MAPK activation
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5689880 Ub-specific processing proteases
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-9020702 Interleukin-1 signaling
R-HSA-937042 IRAK2 mediated activation of TAK1 complex
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SignaLinkiQ15750
SIGNORiQ15750

Protein family/group databases

MoonDBiQ15750 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
TGF-beta-activated kinase 1-binding protein 1
Short name:
TAK1-binding protein 1
Gene namesi
Name:TAB1
Synonyms:MAP3K7IP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100324.13
HGNCiHGNC:18157 TAB1
MIMi602615 gene
neXtProtiNX_Q15750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi213D → A: Loss of interaction with XIAP. 1 Publication1
Mutagenesisi216F → A: Loss of interaction with XIAP. 1 Publication1
Mutagenesisi438S → A: Loss of phosphorylation site. 1 Publication1
Mutagenesisi484F → A: Abolishes interaction with MAP3K7. 1 Publication1

Organism-specific databases

DisGeNETi10454
OpenTargetsiENSG00000100324
PharmGKBiPA30604

Chemistry databases

ChEMBLiCHEMBL5605

Polymorphism and mutation databases

BioMutaiTAB1
DMDMi10720303

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577971 – 504TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1 Publication1
Modified residuei442PhosphothreonineCombined sources1

Post-translational modificationi

Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15750
MaxQBiQ15750
PaxDbiQ15750
PeptideAtlasiQ15750
PRIDEiQ15750
ProteomicsDBi60741
60742 [Q15750-2]

PTM databases

iPTMnetiQ15750
PhosphoSitePlusiQ15750

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000100324 Expressed in 188 organ(s), highest expression level in corpus callosum
CleanExiHS_MAP3K7IP1
ExpressionAtlasiQ15750 baseline and differential
GenevisibleiQ15750 HS

Organism-specific databases

HPAiCAB032328
HPA039988
HPA057104

Interactioni

Subunit structurei

Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115717, 140 interactors
CORUMiQ15750
DIPiDIP-27524N
ELMiQ15750
IntActiQ15750, 91 interactors
MINTiQ15750
STRINGi9606.ENSP00000216160

Chemistry databases

BindingDBiQ15750

Structurei

Secondary structure

1504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15750
SMRiQ15750
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15750

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 365PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST338

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi452 – 457Poly-Ser6

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00510000048276
HOGENOMiHOG000044226
HOVERGENiHBG007302
InParanoidiQ15750
KOiK04403
OMAiSTNQIYR
OrthoDBiEOG091G0B0E
PhylomeDBiQ15750
TreeFamiTF317785

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q15750-1) [UniParc]FASTAAdd to basket
Also known as: TAB1alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
60 70 80 90 100
DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA
110 120 130 140 150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK
160 170 180 190 200
ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV
210 220 230 240 250
TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY
260 270 280 290 300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH
310 320 330 340 350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR
360 370 380 390 400
FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST
410 420 430 440 450
SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT
460 470 480 490 500
QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV

VTAP
Length:504
Mass (Da):54,644
Last modified:November 1, 1996 - v1
Checksum:iA45743288718983A
GO
Isoform 2 (identifier: Q15750-2) [UniParc]FASTAAdd to basket
Also known as: TAB1beta

The sequence of this isoform differs from the canonical sequence as follows:
     436-504: NQSPTLTLQS...HGEQSVVTAP → KDPSRPASDLTAIPQCQLNLLGSLTPG

Note: Does not bind nor activate MAP3K7/TAK1.
Show »
Length:462
Mass (Da):49,917
Checksum:iE26443BBE3BD3404
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039271224D → E. Corresponds to variant dbSNP:rs17001096Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042024436 – 504NQSPT…VVTAP → KDPSRPASDLTAIPQCQLNL LGSLTPG in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49928 mRNA Translation: AAC12660.1
AF425640 mRNA Translation: AAN32760.1
DQ314876 Genomic DNA Translation: ABC40735.1
AL022312 Genomic DNA No translation available.
Z83845 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60326.1
BC050554 mRNA Translation: AAH50554.1
CCDSiCCDS13992.1 [Q15750-2]
CCDS13993.1 [Q15750-1]
RefSeqiNP_006107.1, NM_006116.2 [Q15750-1]
NP_705717.1, NM_153497.2 [Q15750-2]
UniGeneiHs.507681
Hs.729080

Genome annotation databases

EnsembliENST00000216160; ENSP00000216160; ENSG00000100324 [Q15750-1]
ENST00000331454; ENSP00000333049; ENSG00000100324 [Q15750-2]
GeneIDi10454
KEGGihsa:10454
UCSCiuc003axt.4 human [Q15750-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49928 mRNA Translation: AAC12660.1
AF425640 mRNA Translation: AAN32760.1
DQ314876 Genomic DNA Translation: ABC40735.1
AL022312 Genomic DNA No translation available.
Z83845 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60326.1
BC050554 mRNA Translation: AAH50554.1
CCDSiCCDS13992.1 [Q15750-2]
CCDS13993.1 [Q15750-1]
RefSeqiNP_006107.1, NM_006116.2 [Q15750-1]
NP_705717.1, NM_153497.2 [Q15750-2]
UniGeneiHs.507681
Hs.729080

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J4OX-ray2.25A1-401[»]
2POMX-ray2.27A1-370[»]
2POPX-ray3.10A/C1-370[»]
2YDSX-ray2.55T392-398[»]
2YIYX-ray2.49A468-497[»]
4AY5X-ray3.15I/J/K/L389-399[»]
4AY6X-ray3.30E/F/G/H389-401[»]
4GS6X-ray2.20A468-504[»]
4KA3X-ray2.71B395-415[»]
4L3PX-ray2.68A468-504[»]
4L52X-ray2.54A468-496[»]
4L53X-ray2.55A468-496[»]
4O91X-ray2.39A468-504[»]
5DIYX-ray2.06P/Q392-398[»]
5E7RX-ray2.11A468-504[»]
5GJDX-ray2.79A468-504[»]
5GJFX-ray2.89A468-504[»]
5GJGX-ray2.61A468-504[»]
5J7SX-ray2.37A468-504[»]
5J8IX-ray2.40A468-504[»]
5J9LX-ray2.75A468-497[»]
5JGAX-ray2.00A468-504[»]
5JGBX-ray2.80A468-504[»]
5JGDX-ray3.10A468-504[»]
5JH6X-ray2.37A468-504[»]
5JK3X-ray2.37A468-504[»]
5NZZX-ray2.60A/B/C/D1-504[»]
5O90X-ray2.49B386-414[»]
5V5NX-ray2.01A468-497[»]
5VVUX-ray2.70B/D392-398[»]
ProteinModelPortaliQ15750
SMRiQ15750
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115717, 140 interactors
CORUMiQ15750
DIPiDIP-27524N
ELMiQ15750
IntActiQ15750, 91 interactors
MINTiQ15750
STRINGi9606.ENSP00000216160

Chemistry databases

BindingDBiQ15750
ChEMBLiCHEMBL5605

Protein family/group databases

MoonDBiQ15750 Predicted

PTM databases

iPTMnetiQ15750
PhosphoSitePlusiQ15750

Polymorphism and mutation databases

BioMutaiTAB1
DMDMi10720303

Proteomic databases

EPDiQ15750
MaxQBiQ15750
PaxDbiQ15750
PeptideAtlasiQ15750
PRIDEiQ15750
ProteomicsDBi60741
60742 [Q15750-2]

Protocols and materials databases

DNASUi10454
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216160; ENSP00000216160; ENSG00000100324 [Q15750-1]
ENST00000331454; ENSP00000333049; ENSG00000100324 [Q15750-2]
GeneIDi10454
KEGGihsa:10454
UCSCiuc003axt.4 human [Q15750-1]

Organism-specific databases

CTDi10454
DisGeNETi10454
EuPathDBiHostDB:ENSG00000100324.13
GeneCardsiTAB1
HGNCiHGNC:18157 TAB1
HPAiCAB032328
HPA039988
HPA057104
MIMi602615 gene
neXtProtiNX_Q15750
OpenTargetsiENSG00000100324
PharmGKBiPA30604
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00510000048276
HOGENOMiHOG000044226
HOVERGENiHBG007302
InParanoidiQ15750
KOiK04403
OMAiSTNQIYR
OrthoDBiEOG091G0B0E
PhylomeDBiQ15750
TreeFamiTF317785

Enzyme and pathway databases

ReactomeiR-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-450302 activated TAK1 mediates p38 MAPK activation
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5689880 Ub-specific processing proteases
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-9020702 Interleukin-1 signaling
R-HSA-937042 IRAK2 mediated activation of TAK1 complex
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SignaLinkiQ15750
SIGNORiQ15750

Miscellaneous databases

ChiTaRSiTAB1 human
EvolutionaryTraceiQ15750
GeneWikiiMAP3K7IP1
GenomeRNAii10454
PROiPR:Q15750
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100324 Expressed in 188 organ(s), highest expression level in corpus callosum
CleanExiHS_MAP3K7IP1
ExpressionAtlasiQ15750 baseline and differential
GenevisibleiQ15750 HS

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAB1_HUMAN
AccessioniPrimary (citable) accession number: Q15750
Secondary accession number(s): Q2PP09, Q8IZW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 185 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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