TAB1

Functionⁱ

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Caution

Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	484	Required for interaction with MAP3K71 Publication		1

GO - Molecular functionⁱ

enzyme activator activity
Source: ProtInc
Traceable author statementⁱ
- 8638164
kinase activator activity Source: Ensembl
mitogen-activated protein kinase p38 binding Source: Ensembl
protein-containing complex binding Source: Ensembl
protein serine/threonine phosphatase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity Source: Reactome
activation of MAPKKK activity
Source: ProtInc
Traceable author statementⁱ
- 8638164
aorta development Source: Ensembl
cardiac septum development Source: Ensembl
coronary vasculature development Source: Ensembl
Fc-epsilon receptor signaling pathway Source: Reactome
heart morphogenesis Source: Ensembl
I-kappaB kinase/NF-kappaB signaling Source: Reactome
interleukin-1-mediated signaling pathway Source: Reactome
in utero embryonic development Source: Ensembl
JNK cascade Source: Reactome
lung development Source: Ensembl
MyD88-dependent toll-like receptor signaling pathway Source: Reactome
nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
positive regulation of NF-kappaB transcription factor activity Source: Reactome
protein deubiquitination Source: Reactome
stimulatory C-type lectin receptor signaling pathway Source: Reactome
transforming growth factor beta receptor signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-5689880 Ub-specific processing proteases R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9020702 Interleukin-1 signaling R-HSA-937042 IRAK2 mediated activation of TAK1 complex R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SignaLinkⁱ	Q15750
SIGNORⁱ	Q15750

Protein family/group databases

MoonDBⁱ	Q15750 Predicted

MoonDBⁱ

Q15750 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Alternative name(s): Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 TGF-beta-activated kinase 1-binding protein 1 Short name: TAK1-binding protein 1
Gene namesⁱ	Name:TAB1 Synonyms:MAP3K7IP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100324.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18157 TAB1
MIMⁱ	602615 gene
neXtProtⁱ	NX_Q15750

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	213	D → A: Loss of interaction with XIAP. 1 Publication	1
Mutagenesisⁱ	216	F → A: Loss of interaction with XIAP. 1 Publication	1
Mutagenesisⁱ	438	S → A: Loss of phosphorylation site. 1 Publication	1
Mutagenesisⁱ	484	F → A: Abolishes interaction with MAP3K7. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10454
Open Targets More...OpenTargetsⁱ	ENSG00000100324
PharmGKBⁱ	PA30604

Chemistry databases

ChEMBLⁱ	CHEMBL5605

ChEMBLⁱ

CHEMBL5605

Polymorphism and mutation databases

BioMutaⁱ	TAB1
DMDMⁱ	10720303

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000057797	1 – 504	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Add BLAST		504

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	7	PhosphoserineCombined sources	1
Modified residueⁱ	378	PhosphoserineCombined sources	1
Modified residueⁱ	438	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	442	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q15750
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15750
PaxDbⁱ	Q15750
PeptideAtlas More...PeptideAtlasⁱ	Q15750
PRIDEⁱ	Q15750
ProteomicsDBⁱ	60741 60742 [Q15750-2]

PTM databases

iPTMnetⁱ	Q15750
PhosphoSitePlusⁱ	Q15750

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000100324 Expressed in 188 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_MAP3K7IP1
ExpressionAtlasⁱ	Q15750 baseline and differential
Genevisibleⁱ	Q15750 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB032328 HPA039988 HPA057104

HPAⁱ

CAB032328
HPA039988
HPA057104

Interactionⁱ

Subunit structureⁱ

Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ARRB2	P32121	3	EBI-358643,EBI-714559
MAP3K7	O43318	4	EBI-358643,EBI-358684
MAP3K7	O43318-2	3	EBI-358643,EBI-358700
MAPK14	Q16539	2	EBI-358643,EBI-73946
OGT	O15294	3	EBI-358643,EBI-539828
TAB2	Q9NYJ8	5	EBI-358643,EBI-358708

GO - Molecular functionⁱ

mitogen-activated protein kinase p38 binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115717, 140 interactors
CORUMⁱ	Q15750
Database of interacting proteins More...DIPⁱ	DIP-27524N
ELMⁱ	Q15750
IntActⁱ	Q15750, 91 interactors
Molecular INTeraction database More...MINTⁱ	Q15750
STRINGⁱ	9606.ENSP00000216160

Chemistry databases

BindingDBⁱ

Q15750

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	18 – 20	Combined sources	3
Beta strandⁱ	27 – 32	Combined sources	6
Beta strandⁱ	35 – 37	Combined sources	3
Beta strandⁱ	39 – 42	Combined sources	4
Beta strandⁱ	44 – 46	Combined sources	3
Beta strandⁱ	51 – 58	Combined sources	8
Turnⁱ	59 – 61	Combined sources	3
Beta strandⁱ	62 – 74	Combined sources	13
Helixⁱ	75 – 86	Combined sources	12
Beta strandⁱ	89 – 92	Combined sources	4
Beta strandⁱ	94 – 96	Combined sources	3
Helixⁱ	99 – 133	Combined sources	35
Helixⁱ	141 – 143	Combined sources	3
Helixⁱ	146 – 148	Combined sources	3
Helixⁱ	149 – 162	Combined sources	14
Beta strandⁱ	165 – 174	Combined sources	10
Beta strandⁱ	177 – 185	Combined sources	9
Beta strandⁱ	187 – 193	Combined sources	7
Beta strandⁱ	195 – 202	Combined sources	8
Helixⁱ	212 – 219	Combined sources	8
Turnⁱ	220 – 222	Combined sources	3
Helixⁱ	225 – 231	Combined sources	7
Beta strandⁱ	234 – 236	Combined sources	3
Beta strandⁱ	239 – 241	Combined sources	3
Helixⁱ	246 – 250	Combined sources	5
Helixⁱ	252 – 254	Combined sources	3
Turnⁱ	256 – 260	Combined sources	5
Beta strandⁱ	265 – 267	Combined sources	3
Beta strandⁱ	271 – 277	Combined sources	7
Beta strandⁱ	283 – 288	Combined sources	6
Helixⁱ	290 – 300	Combined sources	11
Beta strandⁱ	302 – 304	Combined sources	3
Helixⁱ	305 – 319	Combined sources	15
Helixⁱ	323 – 343	Combined sources	21
Helixⁱ	348 – 351	Combined sources	4
Beta strandⁱ	353 – 355	Combined sources	3
Beta strandⁱ	358 – 366	Combined sources	9
Beta strandⁱ	474 – 476	Combined sources	3
Helixⁱ	485 – 495	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15750
SMRⁱ	Q15750
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q15750

EvolutionaryTraceⁱ

Q15750

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 365	PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST		338

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	452 – 457	Poly-Ser		6

Phylogenomic databases

eggNOGⁱ	KOG0698 Eukaryota COG0631 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048276
HOGENOMⁱ	HOG000044226
HOVERGENⁱ	HBG007302
InParanoidⁱ	Q15750
KEGG Orthology (KO) More...KOⁱ	K04403
OMAⁱ	STNQIYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B0E
PhylomeDBⁱ	Q15750
TreeFamⁱ	TF317785

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00143 PP2Cc, 1 hit
Gene3Dⁱ	3.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR015655 PP2C IPR036457 PPM-type_dom_sf IPR001932 PPM-type_phosphatase_dom
PANTHERⁱ	PTHR13832 PTHR13832, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00481 PP2C, 1 hit
SMARTⁱ	View protein in SMART SM00332 PP2Cc, 1 hit
SUPFAMⁱ	SSF81606 SSF81606, 1 hit
PROSITEⁱ	View protein in PROSITE PS51746 PPM_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q15750-1) [UniParc]FASTA Add to basket

Also known as: TAB1alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE 
        60         70         80         90        100
DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA 
       110        120        130        140        150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK 
       160        170        180        190        200
ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV 
       210        220        230        240        250
TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY 
       260        270        280        290        300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 
       310        320        330        340        350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR 
       360        370        380        390        400
FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST 
       410        420        430        440        450
SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT 
       460        470        480        490        500
QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV 

VTAP

Length:504

Mass (Da):54,644

Last modified:November 1, 1996 - v1

Checksum:ⁱA45743288718983A

GO

Isoform 2 (identifier: Q15750-2) [UniParc]FASTA Add to basket

Also known as: TAB1beta

The sequence of this isoform differs from the canonical sequence as follows:
436-504: NQSPTLTLQS...HGEQSVVTAP → KDPSRPASDLTAIPQCQLNLLGSLTPG

« Hide

        10         20         30         40         50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE 
        60         70         80         90        100
DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA 
       110        120        130        140        150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK 
       160        170        180        190        200
ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV 
       210        220        230        240        250
TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY 
       260        270        280        290        300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 
       310        320        330        340        350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR 
       360        370        380        390        400
FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST 
       410        420        430        440        450
SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTKDPSR PASDLTAIPQ 
       460 
CQLNLLGSLT PG

Note: Does not bind nor activate MAP3K7/TAK1.

Show »

Length:462

Mass (Da):49,917

Checksum:ⁱE26443BBE3BD3404

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_039271	224	D → E. Corresponds to variant dbSNP:rs17001096Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042024	436 – 504	NQSPT…VVTAP → KDPSRPASDLTAIPQCQLNL LGSLTPG in isoform 2. 1 PublicationAdd BLAST		69

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U49928 mRNA Translation: AAC12660.1 AF425640 mRNA Translation: AAN32760.1 DQ314876 Genomic DNA Translation: ABC40735.1 AL022312 Genomic DNA No translation available. Z83845 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60326.1 BC050554 mRNA Translation: AAH50554.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13992.1 [Q15750-2] CCDS13993.1 [Q15750-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_006107.1, NM_006116.2 [Q15750-1] NP_705717.1, NM_153497.2 [Q15750-2]
UniGeneⁱ	Hs.507681 Hs.729080

Genome annotation databases

Ensemblⁱ	ENST00000216160; ENSP00000216160; ENSG00000100324 [Q15750-1] ENST00000331454; ENSP00000333049; ENSG00000100324 [Q15750-2]
GeneIDⁱ	10454
KEGGⁱ	hsa:10454
UCSC genome browser More...UCSCⁱ	uc003axt.4 human [Q15750-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q15750	Mitogen-activated protein kinase kinase kinase 7 interacting protein 1, isoform CRA_f		HUMAN		504	UniRef100_Q15750
TGF-beta activated kinase 1 (MAP3K7) binding protein 1		MACMU		504
TAB1 isoform 2		PANTR		504
TGF-beta activated kinase 1 (MAP3K7) binding protein 1		MACFA		504
Uncharacterized protein		CERAT		504
+5
Q15750-2	TGF-beta activated kinase 1 (MAP3K7) binding protein 1		PANTR		462	UniRef100_A0A2I3RQC4
Uncharacterized protein		PANPA		462
Uncharacterized protein		NOMLE		462

Protein	Similar proteins		Species	Score	Length	Source
Q15750	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	)	MOUSE		502	UniRef90_Q15750
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1, isoform CRA_f		HUMAN		504
TGF-beta activated kinase 1 (MAP3K7) binding protein 1		MACMU		504
TAB1 isoform 2		PANTR		504
TGF-beta activated kinase 1 (MAP3K7) binding protein 1		MACFA		504
+174
Q15750-2	Uncharacterized protein		MACMU		461	UniRef90_F6XMV3
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1		PTEAL		550
TAB1 isoform 2		PONAB		462
TGF-beta activated kinase 1 (MAP3K7) binding protein 1		SAIBB		462
TGF-beta activated kinase 1 (MAP3K7) binding protein 1		GORGO		462
+9

Protein	Similar proteins		Species	Score	Length	Source
Q15750	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	)	MOUSE		502	UniRef50_Q15750
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1, isoform CRA_f		HUMAN		504
TGF-beta activated kinase 1 (MAP3K7) binding protein 1		MACMU		504
TAB1 isoform 2		PANTR		504
TGF-beta activated kinase 1 (MAP3K7) binding protein 1		MACFA		504
+247
Q15750-2	Uncharacterized protein		ANOCA		535	UniRef50_G1KGX0
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1		CROHD		501
Uncharacterized protein (Fragment)		MICSU		458
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Fragment)		EURHL		449
Uncharacterized protein		CHICK		438
+339

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U49928 mRNA Translation: AAC12660.1 AF425640 mRNA Translation: AAN32760.1 DQ314876 Genomic DNA Translation: ABC40735.1 AL022312 Genomic DNA No translation available. Z83845 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60326.1 BC050554 mRNA Translation: AAH50554.1
CCDSⁱ	CCDS13992.1 [Q15750-2] CCDS13993.1 [Q15750-1]
RefSeqⁱ	NP_006107.1, NM_006116.2 [Q15750-1] NP_705717.1, NM_153497.2 [Q15750-2]
UniGeneⁱ	Hs.507681 Hs.729080

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2J4O	X-ray	2.25	A	1-401	[»]
	2POM	X-ray	2.27	A	1-370	[»]
	2POP	X-ray	3.10	A/C	1-370	[»]
	2YDS	X-ray	2.55	T	392-398	[»]
	2YIY	X-ray	2.49	A	468-497	[»]
	4AY5	X-ray	3.15	I/J/K/L	389-399	[»]
	4AY6	X-ray	3.30	E/F/G/H	389-401	[»]
	4GS6	X-ray	2.20	A	468-504	[»]
	4KA3	X-ray	2.71	B	395-415	[»]
	4L3P	X-ray	2.68	A	468-504	[»]
	4L52	X-ray	2.54	A	468-496	[»]
	4L53	X-ray	2.55	A	468-496	[»]
	4O91	X-ray	2.39	A	468-504	[»]
	5DIY	X-ray	2.06	P/Q	392-398	[»]
	5E7R	X-ray	2.11	A	468-504	[»]
	5GJD	X-ray	2.79	A	468-504	[»]
	5GJF	X-ray	2.89	A	468-504	[»]
	5GJG	X-ray	2.61	A	468-504	[»]
	5J7S	X-ray	2.37	A	468-504	[»]
	5J8I	X-ray	2.40	A	468-504	[»]
	5J9L	X-ray	2.75	A	468-497	[»]
	5JGA	X-ray	2.00	A	468-504	[»]
	5JGB	X-ray	2.80	A	468-504	[»]
	5JGD	X-ray	3.10	A	468-504	[»]
	5JH6	X-ray	2.37	A	468-504	[»]
	5JK3	X-ray	2.37	A	468-504	[»]
	5NZZ	X-ray	2.60	A/B/C/D	1-504	[»]
	5O90	X-ray	2.49	B	386-414	[»]
	5V5N	X-ray	2.01	A	468-497	[»]
	5VVU	X-ray	2.70	B/D	392-398	[»]
ProteinModelPortalⁱ	Q15750
SMRⁱ	Q15750
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115717, 140 interactors
CORUMⁱ	Q15750
DIPⁱ	DIP-27524N
ELMⁱ	Q15750
IntActⁱ	Q15750, 91 interactors
MINTⁱ	Q15750
STRINGⁱ	9606.ENSP00000216160

Chemistry databases

BindingDBⁱ	Q15750
ChEMBLⁱ	CHEMBL5605

Protein family/group databases

MoonDBⁱ	Q15750 Predicted

MoonDBⁱ

Q15750 Predicted

PTM databases

iPTMnetⁱ	Q15750
PhosphoSitePlusⁱ	Q15750

Polymorphism and mutation databases

BioMutaⁱ	TAB1
DMDMⁱ	10720303

Proteomic databases

EPDⁱ	Q15750
MaxQBⁱ	Q15750
PaxDbⁱ	Q15750
PeptideAtlasⁱ	Q15750
PRIDEⁱ	Q15750
ProteomicsDBⁱ	60741 60742 [Q15750-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10454
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000216160; ENSP00000216160; ENSG00000100324 [Q15750-1] ENST00000331454; ENSP00000333049; ENSG00000100324 [Q15750-2]
GeneIDⁱ	10454
KEGGⁱ	hsa:10454
UCSCⁱ	uc003axt.4 human [Q15750-1]

Organism-specific databases

CTDⁱ	10454
DisGeNETⁱ	10454
EuPathDBⁱ	HostDB:ENSG00000100324.13
GeneCardsⁱ	TAB1
HGNCⁱ	HGNC:18157 TAB1
HPAⁱ	CAB032328 HPA039988 HPA057104
MIMⁱ	602615 gene
neXtProtⁱ	NX_Q15750
OpenTargetsⁱ	ENSG00000100324
PharmGKBⁱ	PA30604
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0698 Eukaryota COG0631 LUCA
GeneTreeⁱ	ENSGT00510000048276
HOGENOMⁱ	HOG000044226
HOVERGENⁱ	HBG007302
InParanoidⁱ	Q15750
KOⁱ	K04403
OMAⁱ	STNQIYR
OrthoDBⁱ	EOG091G0B0E
PhylomeDBⁱ	Q15750
TreeFamⁱ	TF317785

Enzyme and pathway databases

Reactomeⁱ	R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-5689880 Ub-specific processing proteases R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9020702 Interleukin-1 signaling R-HSA-937042 IRAK2 mediated activation of TAK1 complex R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SignaLinkⁱ	Q15750
SIGNORⁱ	Q15750

Miscellaneous databases

ChiTaRSⁱ	TAB1 human
EvolutionaryTraceⁱ	Q15750
GeneWikiⁱ	MAP3K7IP1
GenomeRNAiⁱ	10454
Protein Ontology More...PROⁱ	PR:Q15750
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100324 Expressed in 188 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_MAP3K7IP1
ExpressionAtlasⁱ	Q15750 baseline and differential
Genevisibleⁱ	Q15750 HS

Family and domain databases

CDDⁱ	cd00143 PP2Cc, 1 hit
Gene3Dⁱ	3.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR015655 PP2C IPR036457 PPM-type_dom_sf IPR001932 PPM-type_phosphatase_dom
PANTHERⁱ	PTHR13832 PTHR13832, 1 hit
Pfamⁱ	View protein in Pfam PF00481 PP2C, 1 hit
SMARTⁱ	View protein in SMART SM00332 PP2Cc, 1 hit
SUPFAMⁱ	SSF81606 SSF81606, 1 hit
PROSITEⁱ	View protein in PROSITE PS51746 PPM_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAB1_HUMAN
Accessionⁱ	Q15750Primary (citable) accession number: Q15750 Secondary accession number(s): Q2PP09, Q8IZW2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 185 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q15750 (TAB1_HUMAN)

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TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

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Organism-specific databases

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Proteomic databases

PTM databases

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Gene expression databases

Organism-specific databases

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Protein-protein interaction databases

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Secondary structure

3D structure databases

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Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ