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UniProtKB - Q15750 (TAB1_HUMAN)

Entry version 200 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene

TAB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Caution

Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei484Required for interaction with MAP3K71 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15750

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-168638, NOD1/2 Signaling Pathway
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-450302, activated TAK1 mediates p38 MAPK activation
R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway
R-HSA-5607764, CLEC7A (Dectin-1) signaling
R-HSA-5689880, Ub-specific processing proteases
R-HSA-9014325, TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-9020702, Interleukin-1 signaling
R-HSA-937042, IRAK2 mediated activation of TAK1 complex
R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-9645460, Alpha-protein kinase 1 signaling pathway
R-HSA-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15750

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15750

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q15750, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
TGF-beta-activated kinase 1-binding protein 1
Short name:
TAK1-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAB1
Synonyms:MAP3K7IP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000100324.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:18157, TAB1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602615, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi213D → A: Loss of interaction with XIAP. 1 Publication1
Mutagenesisi216F → A: Loss of interaction with XIAP. 1 Publication1
Mutagenesisi438S → A: Loss of phosphorylation site. 1 Publication1
Mutagenesisi484F → A: Abolishes interaction with MAP3K7. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10454

Open Targets

More...OpenTargetsi		ENSG00000100324

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30604

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15750, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5605

Drug and drug target database

More...DrugBanki		DB06757, Manganese

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TAB1

Domain mapping of disease mutations (DMDM)

More...DMDMi		10720303

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000577971 – 504TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1 Publication1
Modified residuei442PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-906
CPTAC-907

Encyclopedia of Proteome Dynamics

More...EPDi		Q15750

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15750

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15750

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15750

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15750

PeptideAtlas

More...PeptideAtlasi		Q15750

PRoteomics IDEntifications database

More...PRIDEi		Q15750

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60741 [Q15750-1]
60742 [Q15750-2]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		TAB1

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q15750, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15750

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15750

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100324, Expressed in sural nerve and 200 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15750, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15750, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100324, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055).

Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115717, 168 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15750

Database of interacting proteins

More...DIPi		DIP-27524N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q15750

Protein interaction database and analysis system

More...IntActi		Q15750, 122 interactors

Molecular INTeraction database

More...MINTi		Q15750

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216160

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q15750

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15750, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15750

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15750

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 365PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST338

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi452 – 457Poly-Ser6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0698, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000048276

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027717_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15750

KEGG Orthology (KO)

More...KOi		K04403

Identification of Orthologs from Complete Genome Data

More...OMAi		NTRCLGN

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15750

TreeFam database of animal gene trees

More...TreeFami		TF317785

Family and domain databases

Conserved Domains Database

More...CDDi		cd00143, PP2Cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015655, PP2C
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom

The PANTHER Classification System

More...PANTHERi		PTHR13832, PTHR13832, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00481, PP2C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00332, PP2Cc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81606, SSF81606, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51746, PPM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q15750-1) [UniParc]FASTAAdd to basket
Also known as: TAB1alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE 
        60         70         80         90        100
DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA 
       110        120        130        140        150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK 
       160        170        180        190        200
ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV 
       210        220        230        240        250
TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY 
       260        270        280        290        300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 
       310        320        330        340        350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR 
       360        370        380        390        400
FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST 
       410        420        430        440        450
SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT 
       460        470        480        490        500
QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV 

VTAP
Length:504
Mass (Da):54,644
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA45743288718983A
GO
Isoform 2 (identifier: Q15750-2) [UniParc]FASTAAdd to basket
Also known as: TAB1beta

The sequence of this isoform differs from the canonical sequence as follows:
     436-504: NQSPTLTLQS...HGEQSVVTAP → KDPSRPASDLTAIPQCQLNLLGSLTPG

Note: Does not bind nor activate MAP3K7/TAK1.Curated
Show »
Length:462
Mass (Da):49,917
Checksum:iE26443BBE3BD3404
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039271224D → E. Corresponds to variant dbSNP:rs17001096Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042024436 – 504NQSPT…VVTAP → KDPSRPASDLTAIPQCQLNL LGSLTPG in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U49928 mRNA Translation: AAC12660.1
AF425640 mRNA Translation: AAN32760.1
DQ314876 Genomic DNA Translation: ABC40735.1
AL022312 Genomic DNA No translation available.
Z83845 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60326.1
BC050554 mRNA Translation: AAH50554.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13992.1 [Q15750-2]
CCDS13993.1 [Q15750-1]

NCBI Reference Sequences

More...RefSeqi		NP_006107.1, NM_006116.2 [Q15750-1]
NP_705717.1, NM_153497.2 [Q15750-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216160; ENSP00000216160; ENSG00000100324 [Q15750-1]
ENST00000331454; ENSP00000333049; ENSG00000100324 [Q15750-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10454

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10454

UCSC genome browser

More...UCSCi		uc003axt.4, human [Q15750-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49928 mRNA Translation: AAC12660.1
AF425640 mRNA Translation: AAN32760.1
DQ314876 Genomic DNA Translation: ABC40735.1
AL022312 Genomic DNA No translation available.
Z83845 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60326.1
BC050554 mRNA Translation: AAH50554.1
CCDSiCCDS13992.1 [Q15750-2]
CCDS13993.1 [Q15750-1]
RefSeqiNP_006107.1, NM_006116.2 [Q15750-1]
NP_705717.1, NM_153497.2 [Q15750-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J4OX-ray2.25A1-401[»]
2POMX-ray2.27A1-370[»]
2POPX-ray3.10A/C1-370[»]
2YDSX-ray2.55T392-398[»]
2YIYX-ray2.49A468-497[»]
4AY5X-ray3.15I/J/K/L389-399[»]
4AY6X-ray3.30E/F/G/H389-401[»]
4GS6X-ray2.20A468-504[»]
4KA3X-ray2.71B395-415[»]
4L3PX-ray2.68A468-504[»]
4L52X-ray2.54A468-496[»]
4L53X-ray2.55A468-496[»]
4O91X-ray2.39A468-504[»]
5DIYX-ray2.06P/Q392-398[»]
5E7RX-ray2.11A468-504[»]
5GJDX-ray2.79A468-504[»]
5GJFX-ray2.89A468-504[»]
5GJGX-ray2.61A468-504[»]
5J7SX-ray2.37A468-504[»]
5J8IX-ray2.40A468-504[»]
5J9LX-ray2.75A468-497[»]
5JGAX-ray2.00A468-504[»]
5JGBX-ray2.80A468-504[»]
5JGDX-ray3.10A468-504[»]
5JH6X-ray2.37A468-504[»]
5JK3X-ray2.37A468-504[»]
5NZZX-ray2.60A/B/C/D1-504[»]
5O90X-ray2.49B386-414[»]
5V5NX-ray2.01A468-497[»]
5VVUX-ray2.70B/D392-398[»]
SMRiQ15750
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115717, 168 interactors
CORUMiQ15750
DIPiDIP-27524N
ELMiQ15750
IntActiQ15750, 122 interactors
MINTiQ15750
STRINGi9606.ENSP00000216160

Chemistry databases

BindingDBiQ15750
ChEMBLiCHEMBL5605
DrugBankiDB06757, Manganese

Protein family/group databases

MoonDBiQ15750, Predicted

PTM databases

DEPODiTAB1
GlyGeniQ15750, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ15750
PhosphoSitePlusiQ15750

Polymorphism and mutation databases

BioMutaiTAB1
DMDMi10720303

Proteomic databases

CPTACiCPTAC-906
CPTAC-907
EPDiQ15750
jPOSTiQ15750
MassIVEiQ15750
MaxQBiQ15750
PaxDbiQ15750
PeptideAtlasiQ15750
PRIDEiQ15750
ProteomicsDBi60741 [Q15750-1]
60742 [Q15750-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12659, 614 antibodies

The DNASU plasmid repository

More...DNASUi		10454

Genome annotation databases

EnsembliENST00000216160; ENSP00000216160; ENSG00000100324 [Q15750-1]
ENST00000331454; ENSP00000333049; ENSG00000100324 [Q15750-2]
GeneIDi10454
KEGGihsa:10454
UCSCiuc003axt.4, human [Q15750-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10454
DisGeNETi10454
EuPathDBiHostDB:ENSG00000100324.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		TAB1
HGNCiHGNC:18157, TAB1
HPAiENSG00000100324, Low tissue specificity
MIMi602615, gene
neXtProtiNX_Q15750
OpenTargetsiENSG00000100324
PharmGKBiPA30604

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0698, Eukaryota
GeneTreeiENSGT00510000048276
HOGENOMiCLU_027717_1_0_1
InParanoidiQ15750
KOiK04403
OMAiNTRCLGN
PhylomeDBiQ15750
TreeFamiTF317785

Enzyme and pathway databases

PathwayCommonsiQ15750
ReactomeiR-HSA-168638, NOD1/2 Signaling Pathway
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-450302, activated TAK1 mediates p38 MAPK activation
R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway
R-HSA-5607764, CLEC7A (Dectin-1) signaling
R-HSA-5689880, Ub-specific processing proteases
R-HSA-9014325, TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-9020702, Interleukin-1 signaling
R-HSA-937042, IRAK2 mediated activation of TAK1 complex
R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-9645460, Alpha-protein kinase 1 signaling pathway
R-HSA-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SignaLinkiQ15750
SIGNORiQ15750

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10454, 5 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TAB1, human
EvolutionaryTraceiQ15750

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MAP3K7IP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10454
PharosiQ15750, Tbio

Protein Ontology

More...PROi		PR:Q15750
RNActiQ15750, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100324, Expressed in sural nerve and 200 other tissues
ExpressionAtlasiQ15750, baseline and differential
GenevisibleiQ15750, HS

Family and domain databases

CDDicd00143, PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655, PP2C
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom
PANTHERiPTHR13832, PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481, PP2C, 1 hit
SMARTiView protein in SMART
SM00332, PP2Cc, 1 hit
SUPFAMiSSF81606, SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746, PPM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15750
Secondary accession number(s): Q2PP09, Q8IZW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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