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UniProtKB - Q15746 (MYLK_HUMAN)

Entry version 221 (02 Jun 2021)
Sequence version 4 (13 Jul 2010)
Previous versions | rss
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Protein

Myosin light chain kinase, smooth muscle

Gene

MYLK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca2+ entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis.

13 Publications

Miscellaneous

In asthmatic patients, overexpression promotes actin filament propulsion, thus contributing to airway hyperresponsiveness. Some MYLK variants may contribute to acute lung injury (ALI) susceptibility. Potential therapeutic target in the treatment of burn edema.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Isoform 1 is activated by phosphorylation on Tyr-464 and Tyr-471. Isoforms which lack these tyrosine residues are not regulated in this way. All catalytically active isoforms require binding to calcium and calmodulin for activation. Repressed by organometallic pyridylnaphthalimide complexes, wortmannin, ML-7 (a synthetic naphthalenesulphonyl derivative that inhibits the binding of ATP to MLCK) and ML-9.6 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=6.5 µM for MLC (isoform 1 at 22 degrees Celsius)1 Publication
  2. KM=7.2 µM for MLC (isoform 2 at 22 degrees Celsius)1 Publication
  3. KM=9.3 µM for MLC1 Publication
  1. Vmax=11.9 µmol/min/mg enzyme (isoform 1 at 22 degrees Celsius)1 Publication
  2. Vmax=10.9 µmol/min/mg enzyme (isoform 1 at 22 degrees Celsius)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1493ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1585Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1470 – 1478ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.18, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15746

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-445355, Smooth Muscle Contraction
R-HSA-5627123, RHO GTPases activate PAKs

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q15746

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15746

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15746

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin light chain kinase, smooth muscleCurated (EC:2.7.11.18)
Short name:
MLCK
Short name:
smMLCK
Alternative name(s):
Kinase-related protein
Short name:
KRP
Telokin
Cleaved into the following chain:
Myosin light chain kinase, smooth muscle, deglutamylated form
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYLKImported
Synonyms:MLCK, MLCK1, MYLK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7590, MYLK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600922, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15746

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000065534.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Aortic aneurysm, familial thoracic 7 (AAT7)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0655741213V → M in AAT7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs368390254EnsemblClinVar.1
Natural variantiVAR_0834231458 – 1914Missing in AAT7; unknown pathological significance. 1 PublicationAdd BLAST457
Natural variantiVAR_0834241487 – 1914Missing in AAT7; unknown pathological significance. 1 PublicationAdd BLAST428
Natural variantiVAR_0834251491A → S in AAT7; decreases kinase activity. 1 PublicationCorresponds to variant dbSNP:rs1576422965EnsemblClinVar.1
Natural variantiVAR_0655761754A → T in AAT7; 4-fold reduced affinity for calmodulin; decreased kinase activity compared to wild-type protein. 1 Publication1
Natural variantiVAR_0655771759S → P in AAT7; 7-fold reduced affinity for calmodulin; 6-fold decreased Vmax. 1 PublicationCorresponds to variant dbSNP:rs387906781EnsemblClinVar.1
Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by loss of smooth muscle contraction in the bladder and intestine, resulting in abnormal intestinal mobility and pseudo-obstruction, microcolon, megacystis, abdominal pain and malnutrition.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi608K → A: Loss of acetylation and no kinase activity repression by NAA10/ARD1. 1 Publication1

Keywords - Diseasei

Aortic aneurysm, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		4638

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		MYLK

MalaCards human disease database

More...MalaCardsi		MYLK
MIMi249210, phenotype
613780, phenotype

Open Targets

More...OpenTargetsi		ENSG00000065534

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		91387, Familial thoracic aortic aneurysm and aortic dissection
2241, Megacystis-microcolon-intestinal hypoperistalsis syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31388

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15746, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2428

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib

DrugCentral

More...DrugCentrali		Q15746

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1552

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MYLK

Domain mapping of disease mutations (DMDM)

More...DMDMi		300669714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000243541 – 1914Myosin light chain kinase, smooth muscleAdd BLAST1914
ChainiPRO_00004037311 – 1910Myosin light chain kinase, smooth muscle, deglutamylated formBy similarityAdd BLAST1910
Isoform 6 (identifier: Q15746-8)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
Isoform 8 (identifier: Q15746-10)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi182 ↔ 233PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei231Phosphotyrosine; by ABL11 Publication1
Modified residuei305PhosphoserineCombined sources1
Modified residuei343PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Disulfide bondi435 ↔ 487PROSITE-ProRule annotation
Modified residuei464Phosphotyrosine; by ABL1 and SRC3 Publications1
Modified residuei471Phosphotyrosine; by SRC2 Publications1
Disulfide bondi535 ↔ 583PROSITE-ProRule annotation
Modified residuei556Phosphotyrosine; by ABL11 Publication1
Modified residuei608N6-acetyllysine1 Publication1
Modified residuei611Phosphotyrosine; by ABL11 Publication1
Disulfide bondi742 ↔ 805PROSITE-ProRule annotation
Modified residuei792Phosphotyrosine; by ABL11 Publication1
Modified residuei846Phosphotyrosine; by ABL11 Publication1
Modified residuei947PhosphoserineBy similarity1
Disulfide bondi1119 ↔ 1170PROSITE-ProRule annotation
Modified residuei1438PhosphoserineCombined sources1
Modified residuei1449Phosphotyrosine; by ABL11 Publication1
Modified residuei1575Phosphotyrosine; by ABL11 Publication1
Modified residuei1635Phosphotyrosine; by ABL11 Publication1
Modified residuei1759PhosphoserineBy similarity1
Modified residuei1760PhosphoserineBy similarity1
Modified residuei1772PhosphoserineCombined sources1
Modified residuei1773PhosphoserineBy similarity1
Modified residuei1776PhosphoserineCombined sources1
Modified residuei1778PhosphothreonineBy similarity1
Modified residuei1779PhosphoserineCombined sources1
Disulfide bondi1830 ↔ 1882PROSITE-ProRule annotation
Isoform 6 (identifier: Q15746-8)
Modified residuei2N-acetylalanineCombined sources1
Isoform 8 (identifier: Q15746-10)
Modified residuei2N-acetylalanineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Can probably be down-regulated by phosphorylation. Tyrosine phosphorylation by ABL1 increases kinase activity, reverses MLCK-mediated inhibition of Arp2/3-mediated actin polymerization, and enhances CTTN-binding. Phosphorylation by SRC at Tyr-464 and Tyr-471 promotes CTTN binding.3 Publications
The C-terminus is deglutamylated by AGTPBP1/CCP1, AGBL1/CCP4 and AGBL4/CCP6, leading to the formation of Myosin light chain kinase, smooth muscle, deglutamylated form. The consequences of C-terminal deglutamylation are unknown (By similarity).By similarity
Acetylated at Lys-608 by NAA10/ARD1 via a calcium-dependent signaling; this acetylation represses kinase activity and reduces tumor cell migration.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15746

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15746

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15746

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15746

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15746

PeptideAtlas

More...PeptideAtlasi		Q15746

PRoteomics IDEntifications database

More...PRIDEi		Q15746

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5180
60733 [Q15746-1]
60734 [Q15746-2]
60735 [Q15746-3]
60736 [Q15746-4]
60737 [Q15746-5]
60738 [Q15746-6]
60739 [Q15746-7]
60740 [Q15746-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15746

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q15746

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15746

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues. Accumulates in well differentiated enterocytes of the intestinal epithelium in response to tumor necrosis factor (TNF).4 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Accumulates in individuals with asthma (at protein levels). Induced by tumor necrosis factor (TNF). Repressed by androgens (e.g. R1881).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000065534, Expressed in cauda epididymis and 253 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15746, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15746, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000065534, Tissue enhanced (smooth)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

All isoforms including Telokin bind calmodulin.

Interacts with SVIL (By similarity).

Interacts with CTTN; this interaction is reduced during thrombin-induced endothelial cell (EC) contraction but is promoted by the barrier-protective agonist sphingosine 1-phosphate (S1P) within lamellipodia. A complex made of ABL1, CTTN and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Binds to NAA10/ARD1 and PTK2B/PYK2.

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110722, 24 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15746

Protein interaction database and analysis system

More...IntActi		Q15746, 28 interactors

Molecular INTeraction database

More...MINTi		Q15746

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000353452

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q15746

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15746, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11914
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15746

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15746

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 122Ig-like C2-type 1Add BLAST90
Domaini161 – 249Ig-like C2-type 2Add BLAST89
Domaini414 – 503Ig-like C2-type 3Add BLAST90
Domaini514 – 599Ig-like C2-type 4Add BLAST86
Domaini620 – 711Ig-like C2-type 5Add BLAST92
Domaini721 – 821Ig-like C2-type 6Add BLAST101
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati868 – 8951-1Add BLAST28
Repeati896 – 9231-2Add BLAST28
Repeati924 – 9511-3Add BLAST28
Repeati952 – 9791-4Add BLAST28
Repeati980 – 9981-5; truncatedAdd BLAST19
Repeati999 – 10032-1; truncated5
Repeati1004 – 10152-2Add BLAST12
Repeati1016 – 10272-3Add BLAST12
Repeati1028 – 10392-4Add BLAST12
Repeati1040 – 10512-5Add BLAST12
Repeati1052 – 10632-6Add BLAST12
Domaini1098 – 1186Ig-like C2-type 7Add BLAST89
Domaini1238 – 1326Ig-like C2-type 8Add BLAST89
Domaini1334 – 1426Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST93
Domaini1464 – 1719Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini1809 – 1898Ig-like C2-type 9Add BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni286 – 393DisorderedSequence analysisAdd BLAST108
Regioni868 – 9985 X 28 AA approximate tandem repeatsAdd BLAST131
Regioni923 – 963Actin-binding (calcium/calmodulin-sensitive)By similarityAdd BLAST41
Regioni932 – 1098DisorderedSequence analysisAdd BLAST167
Regioni948 – 963Calmodulin-bindingBy similarityAdd BLAST16
Regioni999 – 10636 X 12 AA approximate tandem repeatsAdd BLAST65
Regioni1061 – 1460Actin-binding (calcium/calmodulin-insensitive)By similarityAdd BLAST400
Regioni1192 – 1237DisorderedSequence analysisAdd BLAST46
Regioni1413 – 1446DisorderedSequence analysisAdd BLAST34
Regioni1711 – 1774Calmodulin-bindingAdd BLAST64
Regioni1767 – 1787DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi292 – 319Polar residuesSequence analysisAdd BLAST28
Compositional biasi327 – 350Polar residuesSequence analysisAdd BLAST24
Compositional biasi935 – 949Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi995 – 1022Polar residuesSequence analysisAdd BLAST28
Compositional biasi1058 – 1088Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1767 – 1783Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0613, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157879

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_76_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15746

Identification of Orthologs from Complete Genome Data

More...OMAi		DVNCKKG

Database of Orthologous Groups

More...OrthoDBi		330091at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15746

TreeFam database of animal gene trees

More...TreeFami		TF314166

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 1 hit
cd14191, STKc_MLCK1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR015725, MLCK1_kinase_dom
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 1 hit
PF07679, I-set, 9 hits
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 1 hit
SM00409, IG, 9 hits
SM00408, IGc2, 9 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 9 hits
SSF49265, SSF49265, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 1 hit
PS50835, IG_LIKE, 9 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 11 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15746-1) [UniParc]FASTAAdd to basket
Also known as: Non-muscle isozyme

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA 
        60         70         80         90        100
KFEGRVRGYP EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED 
       110        120        130        140        150
RGKYTCEATN GSGARQVTVE LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE 
       160        170        180        190        200
TRPSIWGECP PKFATKLGRV VVKEGQMGRF SCKITGRPQP QVTWLKGNVP 
       210        220        230        240        250
LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG KASMSAELSI 
       260        270        280        290        300
QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP 
       310        320        330        340        350
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA 
       360        370        380        390        400
RVQPEPRAPG LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN 
       410        420        430        440        450
RRIPMEGQRD SAFPKFESKP QSQEVKENQT VKFRCEVSGI PKPEVAWFLE 
       460        470        480        490        500
GTPVRRQEGS IEVYEDAGSH YLCLLKARTR DSGTYSCTAS NAQGQLSCSW 
       510        520        530        540        550
TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT PVPRITWLLN 
       560        570        580        590        600
GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV 
       610        620        630        640        650
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP 
       660        670        680        690        700
PPEVIWLHNG NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS 
       710        720        730        740        750
AGEVRTQAVL TVQEPHDGTQ PWFISKPRSV TASLGQSVLI SCAIAGDPFP 
       760        770        780        790        800
TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV LKKVQPWHAG QYEILLKNRV 
       810        820        830        840        850
GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG GGSDRYGSLR 
       860        870        880        890        900
PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL 
       910        920        930        940        950
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ 
       960        970        980        990       1000
VDFRSVLAKK GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA 
      1010       1020       1030       1040       1050
ETLNAKAVES SKPLSNAQPS GPLKPVGNAK PAETLKPMGN AKPAETLKPM 
      1060       1070       1080       1090       1100
GNAKPDENLK SASKEELKKD VKNDVNCKRG HAGTTDNEKR SESQGTAPAF 
      1110       1120       1130       1140       1150
KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT TKFIILSQEG 
      1160       1170       1180       1190       1200
SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE 
      1210       1220       1230       1240       1250
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR 
      1260       1270       1280       1290       1300
AGESVELFGK VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA 
      1310       1320       1330       1340       1350
RQEHCGCYTL LVENKLGSRQ AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL 
      1360       1370       1380       1390       1400
SWYGSSYDGG SAVQSYSIEI WDSANKTWKE LATCRSTSFN VQDLLPDHEY 
      1410       1420       1430       1440       1450
KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD DEKEPEVDYR 
      1460       1470       1480       1490       1500
TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA 
      1510       1520       1530       1540       1550
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI 
      1560       1570       1580       1590       1600
IDEDFELTER ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR 
      1610       1620       1630       1640       1650
IKLIDFGLAR RLENAGSLKV LFGTPEFVAP EVINYEPIGY ATDMWSIGVI 
      1660       1670       1680       1690       1700
CYILVSGLSP FMGDNDNETL ANVTSATWDF DDEAFDEISD DAKDFISNLL 
      1710       1720       1730       1740       1750
KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM ARRKWQKTGN 
      1760       1770       1780       1790       1800
AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV 
      1810       1820       1830       1840       1850
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR 
      1860       1870       1880       1890       1900
ESRHFQIDYD EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE 
      1910 
TMEEGEGEGE EEEE
Length:1,914
Mass (Da):210,715
Last modified:July 13, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D094E161CE2D4BA
GO
Isoform 2 (identifier: Q15746-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-506: VSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVER → G

Show »
Length:1,845
Mass (Da):203,055
Checksum:i0111D4C5A88349AB
GO
Isoform 3A (identifier: Q15746-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1655-1705: Missing.

Show »
Length:1,863
Mass (Da):205,059
Checksum:iA526210F1B9E546C
GO
Isoform 3B (identifier: Q15746-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-506: VSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVER → G
     1655-1705: Missing.

Show »
Length:1,794
Mass (Da):197,399
Checksum:i9EE35F5BADBB0D9A
GO
Isoform 4 (identifier: Q15746-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1473-1545: Missing.

Show »
Length:1,841
Mass (Da):202,350
Checksum:i23EDB48D1A11DE70
GO
Isoform Del-1790 (identifier: Q15746-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1790-1790: Missing.

Show »
Length:1,913
Mass (Da):210,586
Checksum:i6D3029D5CCA13B41
GO
Isoform 5 (identifier: Q15746-7) [UniParc]FASTAAdd to basket
Also known as: Smooth-muscle isozyme

The sequence of this isoform differs from the canonical sequence as follows:
     1-922: Missing.

Note: Transcribed from an alternative promoter resulting in the usage of Met-923 as initiator codon.1 Publication
Show »
Length:992
Mass (Da):110,205
Checksum:i27288359F94FE260
GO
Isoform 6 (identifier: Q15746-8) [UniParc]FASTAAdd to basket
Also known as: Telokin

The sequence of this isoform differs from the canonical sequence as follows:
     1-1760: Missing.

Note: Transcribed from an alternative promoter resulting in the usage of Met-1761 as initiator codon. Has no catalytic activity. Initiator Met is removed.Curated
Show »
Length:154
Mass (Da):16,970
Checksum:i0E3B6CAD36C563EE
GO
Isoform 7 (identifier: Q15746-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1200: Missing.

Show »
Length:714
Mass (Da):80,410
Checksum:i5C3E8AD06D8B855D
GO
Isoform 8 (identifier: Q15746-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1760: Missing.
     1790-1790: Missing.

Note: Transcribed from an alternative promoter resulting in the usage of Met-1761 as initiator codon. Initiator Met is removed.Curated
Show »
Length:153
Mass (Da):16,840
Checksum:iBF1292FFEB166F7B
GO
Isoform 9 (identifier: Q15746-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-922: Missing.
     1790-1790: Missing.

Note: Transcribed from an alternative promoter resulting in the usage of Met-923 as initiator codon.1 Publication
Show »
Length:991
Mass (Da):110,076
Checksum:iBCFD66306197E14C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9C2D6R9C2_HUMAN
Myosin light chain kinase, smooth m...
MYLK
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBL7F8WBL7_HUMAN
Myosin light chain kinase, smooth m...
MYLK
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD15922 differs from that shown. Reason: Frameshift.Curated
The sequence AAD15923 differs from that shown. Reason: Frameshift.Curated
The sequence AAD15924 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti147P → S in AAC18423 (PubMed:9160829).Curated1
Sequence conflicti147P → S in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti147P → S in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti147P → S in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti147P → S in AAQ02673 (PubMed:15020676).Curated1
Sequence conflicti147P → S in EAW79438 (Ref. 11) Curated1
Sequence conflicti147P → S in EAW79440 (Ref. 11) Curated1
Sequence conflicti466D → N in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti496L → V in AAC18423 (PubMed:9160829).Curated1
Sequence conflicti496L → V in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti496L → V in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti496L → V in AAQ02673 (PubMed:15020676).Curated1
Sequence conflicti681C → W in AAC18423 (PubMed:9160829).Curated1
Sequence conflicti681C → W in AAD15921 (PubMed:10198165).Curated1
Sequence conflicti681C → W in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti681C → W in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti933V → M in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti963S → P in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1022P → A in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1048 – 1050KPM → EAH in CAA59685 (PubMed:8575746).Curated3
Sequence conflicti1048 – 1050KPM → EAH in BAB21504 (Ref. 8) Curated3
Sequence conflicti1162P → L in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1162P → L in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti1210L → P in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1280E → D in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1280E → D in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti1284M → I in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1284M → I in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti1284M → I in AAD15924 (PubMed:10198165).Curated1
Sequence conflicti1300A → G in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1316L → S in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1326T → S in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1478V → C in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1511S → T in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1511S → T in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti1518H → P in AAR29061 (PubMed:15507455).Curated1
Sequence conflicti1518H → P in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti1563I → T in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1609A → P in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1634N → I in AAR29061 (PubMed:15507455).Curated1
Sequence conflicti1634N → I in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti1639 – 1640GY → D in AAD15922 (PubMed:10198165).Curated2
Sequence conflicti1639 – 1640GY → D in AAD15923 (PubMed:10198165).Curated2
Sequence conflicti1639 – 1640GY → D in AAD15924 (PubMed:10198165).Curated2
Sequence conflicti1639G → R in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1648G → R in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1658 – 1659LS → PF in CAA59685 (PubMed:8575746).Curated2
Sequence conflicti1676A → P in AAR29061 (PubMed:15507455).Curated1
Sequence conflicti1676A → P in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti1710 – 1711CT → LA in CAA59685 (PubMed:8575746).Curated2
Sequence conflicti1897L → H in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1897L → H in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti1897L → H in AAD15924 (PubMed:10198165).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05710621P → H. Corresponds to variant dbSNP:rs28497577EnsemblClinVar.1
Natural variantiVAR_065570128A → V1 PublicationCorresponds to variant dbSNP:rs143896146EnsemblClinVar.1
Natural variantiVAR_065571133Q → H1 PublicationCorresponds to variant dbSNP:rs140148380EnsemblClinVar.1
Natural variantiVAR_065572160P → R1 PublicationCorresponds to variant dbSNP:rs111256888EnsemblClinVar.1
Natural variantiVAR_040847261V → A1 PublicationCorresponds to variant dbSNP:rs3796164EnsemblClinVar.1
Natural variantiVAR_040848276T → A1 PublicationCorresponds to variant dbSNP:rs55846245Ensembl.1
Natural variantiVAR_057107336P → L. Corresponds to variant dbSNP:rs35912339EnsemblClinVar.1
Natural variantiVAR_040849378R → H1 PublicationCorresponds to variant dbSNP:rs56378658EnsemblClinVar.1
Natural variantiVAR_040850405M → V1 PublicationCorresponds to variant dbSNP:rs35436690EnsemblClinVar.1
Natural variantiVAR_040851443P → S1 PublicationCorresponds to variant dbSNP:rs35156360EnsemblClinVar.1
Natural variantiVAR_040852607R → G1 Publication1
Natural variantiVAR_040853652P → A1 PublicationCorresponds to variant dbSNP:rs750686734EnsemblClinVar.1
Natural variantiVAR_040854656W → C2 PublicationsCorresponds to variant dbSNP:rs138172035EnsemblClinVar.1
Natural variantiVAR_040855692T → M1 PublicationCorresponds to variant dbSNP:rs776858093Ensembl.1
Natural variantiVAR_040856701A → T1 PublicationCorresponds to variant dbSNP:rs142835596EnsemblClinVar.1
Natural variantiVAR_040857709V → M1 PublicationCorresponds to variant dbSNP:rs112537316EnsemblClinVar.1
Natural variantiVAR_057108845R → C. Corresponds to variant dbSNP:rs3732485EnsemblClinVar.1
Natural variantiVAR_019986861L → P. Corresponds to variant dbSNP:rs3732486EnsemblClinVar.1
Natural variantiVAR_057109877V → M. Corresponds to variant dbSNP:rs34542174EnsemblClinVar.1
Natural variantiVAR_019987914D → E. Corresponds to variant dbSNP:rs3732487EnsemblClinVar.1
Natural variantiVAR_0655731085T → A1 PublicationCorresponds to variant dbSNP:rs75370906EnsemblClinVar.1
Natural variantiVAR_0655741213V → M in AAT7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs368390254EnsemblClinVar.1
Natural variantiVAR_0655751399E → K1 PublicationCorresponds to variant dbSNP:rs181663420EnsemblClinVar.1
Natural variantiVAR_0834231458 – 1914Missing in AAT7; unknown pathological significance. 1 PublicationAdd BLAST457
Natural variantiVAR_0834241487 – 1914Missing in AAT7; unknown pathological significance. 1 PublicationAdd BLAST428
Natural variantiVAR_0834251491A → S in AAT7; decreases kinase activity. 1 PublicationCorresponds to variant dbSNP:rs1576422965EnsemblClinVar.1
Natural variantiVAR_0408581527A → V1 PublicationCorresponds to variant dbSNP:rs34982967Ensembl.1
Natural variantiVAR_0408591588P → L in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1576401641EnsemblClinVar.1
Natural variantiVAR_0655761754A → T in AAT7; 4-fold reduced affinity for calmodulin; decreased kinase activity compared to wild-type protein. 1 Publication1
Natural variantiVAR_0655771759S → P in AAT7; 7-fold reduced affinity for calmodulin; 6-fold decreased Vmax. 1 PublicationCorresponds to variant dbSNP:rs387906781EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0188461 – 1760Missing in isoform 6 and isoform 8. 3 PublicationsAdd BLAST1760
Alternative sequenceiVSP_0537911 – 1200Missing in isoform 7. 1 PublicationAdd BLAST1200
Alternative sequenceiVSP_0188451 – 922Missing in isoform 5 and isoform 9. 2 PublicationsAdd BLAST922
Alternative sequenceiVSP_004791437 – 506VSGIP…LQVER → G in isoform 2 and isoform 3B. 2 PublicationsAdd BLAST70
Alternative sequenceiVSP_0047931473 – 1545Missing in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_0047941655 – 1705Missing in isoform 3A and isoform 3B. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_0047951790Missing in isoform Del-1790, isoform 8 and isoform 9. 4 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X85337 mRNA Translation: CAA59685.1
U48959 mRNA Translation: AAC18423.2
AF069601 mRNA Translation: AAD15921.2
AF069602 mRNA Translation: AAD15922.1 Frameshift.
AF069603 mRNA Translation: AAD15923.1 Frameshift.
AF069604 mRNA Translation: AAD15924.1 Frameshift.
AF096771 AF096770 Genomic DNA Translation: AAD51380.1
AF096771, AF096769, AF096770 Genomic DNA Translation: AAD51381.1
AF096773 mRNA Translation: AAD54017.1
AF096774 mRNA Translation: AAD54018.1
AF096775 mRNA Translation: AAD54019.1
AY424269 mRNA Translation: AAR29061.1
AY424270 mRNA Translation: AAR29062.1
AY339601 mRNA Translation: AAQ02673.1
AB037663 mRNA Translation: BAB21504.1
AK300610 mRNA Translation: BAG62305.1
AK314412 mRNA Translation: BAG37033.1
AK314443 mRNA Translation: BAG37052.1
AC020634 Genomic DNA No translation available.
AC023165 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79438.1
CH471052 Genomic DNA Translation: EAW79439.1
CH471052 Genomic DNA Translation: EAW79440.1
CH471052 Genomic DNA Translation: EAW79441.1
BC100761 mRNA Translation: AAI00762.2
BC100762 mRNA Translation: AAI00763.2
BC100763 mRNA Translation: AAI00764.2
BC064420 mRNA Translation: AAH64420.2
X90870 mRNA Translation: CAA62378.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3023.1 [Q15746-3]
CCDS43141.1 [Q15746-2]
CCDS46896.1 [Q15746-1]
CCDS46897.1 [Q15746-8]
CCDS58849.1 [Q15746-10]

NCBI Reference Sequences

More...RefSeqi		NP_001308238.1, NM_001321309.1
NP_444253.3, NM_053025.3 [Q15746-1]
NP_444254.3, NM_053026.3 [Q15746-2]
NP_444255.3, NM_053027.3 [Q15746-3]
NP_444256.3, NM_053028.3 [Q15746-4]
NP_444259.1, NM_053031.3 [Q15746-10]
NP_444260.1, NM_053032.3 [Q15746-8]
XP_011511162.1, XM_011512860.2
XP_016861958.1, XM_017006469.1 [Q15746-11]
XP_016861960.1, XM_017006471.1 [Q15746-9]
XP_016861961.1, XM_017006472.1 [Q15746-8]
XP_016861962.1, XM_017006473.1 [Q15746-10]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000346322; ENSP00000320622; ENSG00000065534 [Q15746-2]
ENST00000360304; ENSP00000353452; ENSG00000065534 [Q15746-1]
ENST00000360772; ENSP00000354004; ENSG00000065534 [Q15746-3]
ENST00000418370; ENSP00000428967; ENSG00000065534 [Q15746-8]
ENST00000578202; ENSP00000463691; ENSG00000065534 [Q15746-10]
ENST00000583087; ENSP00000462118; ENSG00000065534 [Q15746-8]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4638

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4638

UCSC genome browser

More...UCSCi		uc003egl.4, human [Q15746-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Myosin light-chain kinase entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85337 mRNA Translation: CAA59685.1
U48959 mRNA Translation: AAC18423.2
AF069601 mRNA Translation: AAD15921.2
AF069602 mRNA Translation: AAD15922.1 Frameshift.
AF069603 mRNA Translation: AAD15923.1 Frameshift.
AF069604 mRNA Translation: AAD15924.1 Frameshift.
AF096771 AF096770 Genomic DNA Translation: AAD51380.1
AF096771, AF096769, AF096770 Genomic DNA Translation: AAD51381.1
AF096773 mRNA Translation: AAD54017.1
AF096774 mRNA Translation: AAD54018.1
AF096775 mRNA Translation: AAD54019.1
AY424269 mRNA Translation: AAR29061.1
AY424270 mRNA Translation: AAR29062.1
AY339601 mRNA Translation: AAQ02673.1
AB037663 mRNA Translation: BAB21504.1
AK300610 mRNA Translation: BAG62305.1
AK314412 mRNA Translation: BAG37033.1
AK314443 mRNA Translation: BAG37052.1
AC020634 Genomic DNA No translation available.
AC023165 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79438.1
CH471052 Genomic DNA Translation: EAW79439.1
CH471052 Genomic DNA Translation: EAW79440.1
CH471052 Genomic DNA Translation: EAW79441.1
BC100761 mRNA Translation: AAI00762.2
BC100762 mRNA Translation: AAI00763.2
BC100763 mRNA Translation: AAI00764.2
BC064420 mRNA Translation: AAH64420.2
X90870 mRNA Translation: CAA62378.1
CCDSiCCDS3023.1 [Q15746-3]
CCDS43141.1 [Q15746-2]
CCDS46896.1 [Q15746-1]
CCDS46897.1 [Q15746-8]
CCDS58849.1 [Q15746-10]
RefSeqiNP_001308238.1, NM_001321309.1
NP_444253.3, NM_053025.3 [Q15746-1]
NP_444254.3, NM_053026.3 [Q15746-2]
NP_444255.3, NM_053027.3 [Q15746-3]
NP_444256.3, NM_053028.3 [Q15746-4]
NP_444259.1, NM_053031.3 [Q15746-10]
NP_444260.1, NM_053032.3 [Q15746-8]
XP_011511162.1, XM_011512860.2
XP_016861958.1, XM_017006469.1 [Q15746-11]
XP_016861960.1, XM_017006471.1 [Q15746-9]
XP_016861961.1, XM_017006472.1 [Q15746-8]
XP_016861962.1, XM_017006473.1 [Q15746-10]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQVNMR-A1238-1338[»]
2K0FNMR-B1742-1760[»]
2YR3NMR-A510-601[»]
5JQAX-ray1.80B1742-1761[»]
5JTHX-ray1.84B1742-1761[»]
6C6MX-ray2.50A/B/C405-507[»]
SMRiQ15746
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110722, 24 interactors
CORUMiQ15746
IntActiQ15746, 28 interactors
MINTiQ15746
STRINGi9606.ENSP00000353452

Chemistry databases

BindingDBiQ15746
ChEMBLiCHEMBL2428
DrugBankiDB12010, Fostamatinib
DrugCentraliQ15746
GuidetoPHARMACOLOGYi1552

PTM databases

iPTMnetiQ15746
MetOSiteiQ15746
PhosphoSitePlusiQ15746

Genetic variation databases

BioMutaiMYLK
DMDMi300669714

Proteomic databases

EPDiQ15746
jPOSTiQ15746
MassIVEiQ15746
MaxQBiQ15746
PaxDbiQ15746
PeptideAtlasiQ15746
PRIDEiQ15746
ProteomicsDBi5180
60733 [Q15746-1]
60734 [Q15746-2]
60735 [Q15746-3]
60736 [Q15746-4]
60737 [Q15746-5]
60738 [Q15746-6]
60739 [Q15746-7]
60740 [Q15746-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4044, 377 antibodies

The DNASU plasmid repository

More...DNASUi		4638

Genome annotation databases

EnsembliENST00000346322; ENSP00000320622; ENSG00000065534 [Q15746-2]
ENST00000360304; ENSP00000353452; ENSG00000065534 [Q15746-1]
ENST00000360772; ENSP00000354004; ENSG00000065534 [Q15746-3]
ENST00000418370; ENSP00000428967; ENSG00000065534 [Q15746-8]
ENST00000578202; ENSP00000463691; ENSG00000065534 [Q15746-10]
ENST00000583087; ENSP00000462118; ENSG00000065534 [Q15746-8]
GeneIDi4638
KEGGihsa:4638
UCSCiuc003egl.4, human [Q15746-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4638
DisGeNETi4638

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYLK
GeneReviewsiMYLK
HGNCiHGNC:7590, MYLK
HPAiENSG00000065534, Tissue enhanced (smooth)
MalaCardsiMYLK
MIMi249210, phenotype
600922, gene
613780, phenotype
neXtProtiNX_Q15746
OpenTargetsiENSG00000065534
Orphaneti91387, Familial thoracic aortic aneurysm and aortic dissection
2241, Megacystis-microcolon-intestinal hypoperistalsis syndrome
PharmGKBiPA31388
VEuPathDBiHostDB:ENSG00000065534.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0613, Eukaryota
GeneTreeiENSGT00940000157879
HOGENOMiCLU_000288_76_2_1
InParanoidiQ15746
OMAiDVNCKKG
OrthoDBi330091at2759
PhylomeDBiQ15746
TreeFamiTF314166

Enzyme and pathway databases

BRENDAi2.7.11.18, 2681
PathwayCommonsiQ15746
ReactomeiR-HSA-445355, Smooth Muscle Contraction
R-HSA-5627123, RHO GTPases activate PAKs
SABIO-RKiQ15746
SignaLinkiQ15746
SIGNORiQ15746

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4638, 3 hits in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MYLK, human
EvolutionaryTraceiQ15746

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MYLK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4638
PharosiQ15746, Tchem

Protein Ontology

More...PROi		PR:Q15746
RNActiQ15746, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000065534, Expressed in cauda epididymis and 253 other tissues
ExpressionAtlasiQ15746, baseline and differential
GenevisibleiQ15746, HS

Family and domain databases

CDDicd00063, FN3, 1 hit
cd14191, STKc_MLCK1, 1 hit
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR015725, MLCK1_kinase_dom
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00041, fn3, 1 hit
PF07679, I-set, 9 hits
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 1 hit
SM00409, IG, 9 hits
SM00408, IGc2, 9 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF48726, SSF48726, 9 hits
SSF49265, SSF49265, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853, FN3, 1 hit
PS50835, IG_LIKE, 9 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYLK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15746
Secondary accession number(s): B4DUE3
, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 13, 2010
Last modified: June 2, 2021
This is version 221 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
  5. Human variants curated from literature reports
    Index of human variants curated from literature reports
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families
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