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UniProtKB - Q15746 (MYLK_HUMAN)

Protein

Myosin light chain kinase, smooth muscle

Gene

MYLK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca2+ entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis.13 Publications

Miscellaneous

In asthmatic patients, overexpression promotes actin filament propulsion, thus contributing to airway hyperresponsiveness. Some MYLK variants may contribute to acute lung injury (ALI) susceptibility. Potential therapeutic target in the treatment of burn edema.

Catalytic activityi

ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.

Cofactori

Protein has several cofactor binding sites:

Activity regulationi

Isoform 1 is activated by phosphorylation on Tyr-464 and Tyr-471. Isoforms which lack these tyrosine residues are not regulated in this way. All catalytically active isoforms require binding to calcium and calmodulin for activation. Repressed by organometallic pyridylnaphthalimide complexes, wortmannin, ML-7 (a synthetic naphthalenesulphonyl derivative that inhibits the binding of ATP to MLCK) and ML-9.6 Publications

Kineticsi

  1. KM=6.5 µM for MLC (isoform 1 at 22 degrees Celsius)1 Publication
  2. KM=7.2 µM for MLC (isoform 2 at 22 degrees Celsius)1 Publication
  1. Vmax=11.9 µmol/min/mg enzyme (isoform 1 at 22 degrees Celsius)1 Publication
  2. Vmax=10.9 µmol/min/mg enzyme (isoform 1 at 22 degrees Celsius)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1493ATPPROSITE-ProRule annotation1
Active sitei1585Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1470 – 1478ATPPROSITE-ProRule annotation9

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.18 2681
ReactomeiR-HSA-445355 Smooth Muscle Contraction
R-HSA-5627123 RHO GTPases activate PAKs
SABIO-RKiQ15746
SignaLinkiQ15746
SIGNORiQ15746

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain kinase, smooth muscle (EC:2.7.11.18)
Short name:
MLCK
Short name:
smMLCK
Alternative name(s):
Kinase-related protein
Short name:
KRP
Telokin
Cleaved into the following chain:
Myosin light chain kinase, smooth muscle, deglutamylated form
Gene namesi
Name:MYLK
Synonyms:MLCK, MLCK1, MYLK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000065534.18
HGNCiHGNC:7590 MYLK
MIMi600922 gene
neXtProtiNX_Q15746

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Aortic aneurysm, familial thoracic 7 (AAT7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
See also OMIM:613780
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0655741213V → M in AAT7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs368390254EnsemblClinVar.1
Natural variantiVAR_0655761754A → T in AAT7; 4-fold reduced affinity for calmodulin; decreased kinase activity compared to wild-type protein. 1 Publication1
Natural variantiVAR_0655771759S → P in AAT7; 7-fold reduced affinity for calmodulin; 6-fold decreased Vmax. 1 PublicationCorresponds to variant dbSNP:rs387906781EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi608K → A: Loss of acetylation and no kinase activity repression by NAA10/ARD1. 1 Publication1

Keywords - Diseasei

Aortic aneurysm, Disease mutation

Organism-specific databases

DisGeNETi4638
GeneReviewsiMYLK
MalaCardsiMYLK
MIMi613780 phenotype
OpenTargetsiENSG00000065534
Orphaneti91387 Familial thoracic aortic aneurysm and aortic dissection
PharmGKBiPA31388

Chemistry databases

ChEMBLiCHEMBL2428
GuidetoPHARMACOLOGYi1552

Polymorphism and mutation databases

BioMutaiMYLK
DMDMi300669714

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000243541 – 1914Myosin light chain kinase, smooth muscleAdd BLAST1914
ChainiPRO_00004037311 – 1910Myosin light chain kinase, smooth muscle, deglutamylated formBy similarityAdd BLAST1910
Isoform 6 (identifier: Q15746-8)
Initiator methionineiRemovedCombined sources
Isoform 8 (identifier: Q15746-10)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi182 ↔ 233PROSITE-ProRule annotation
Modified residuei231Phosphotyrosine; by ABL11 Publication1
Modified residuei305PhosphoserineCombined sources1
Modified residuei343PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Disulfide bondi435 ↔ 487PROSITE-ProRule annotation
Modified residuei464Phosphotyrosine; by ABL1 and SRC3 Publications1
Modified residuei471Phosphotyrosine; by SRC2 Publications1
Disulfide bondi535 ↔ 583PROSITE-ProRule annotation
Modified residuei556Phosphotyrosine; by ABL11 Publication1
Modified residuei608N6-acetyllysine1 Publication1
Modified residuei611Phosphotyrosine; by ABL11 Publication1
Disulfide bondi742 ↔ 805PROSITE-ProRule annotation
Modified residuei792Phosphotyrosine; by ABL11 Publication1
Modified residuei846Phosphotyrosine; by ABL11 Publication1
Modified residuei947PhosphoserineBy similarity1
Disulfide bondi1119 ↔ 1170PROSITE-ProRule annotation
Modified residuei1438PhosphoserineCombined sources1
Modified residuei1449Phosphotyrosine; by ABL11 Publication1
Modified residuei1575Phosphotyrosine; by ABL11 Publication1
Modified residuei1635Phosphotyrosine; by ABL11 Publication1
Modified residuei1759PhosphoserineBy similarity1
Modified residuei1760PhosphoserineBy similarity1
Modified residuei1772PhosphoserineCombined sources1
Modified residuei1773PhosphoserineBy similarity1
Modified residuei1776PhosphoserineCombined sources1
Modified residuei1778PhosphothreonineBy similarity1
Modified residuei1779PhosphoserineCombined sources1
Disulfide bondi1830 ↔ 1882PROSITE-ProRule annotation
Isoform 6 (identifier: Q15746-8)
Modified residuei2N-acetylalanineCombined sources1
Isoform 8 (identifier: Q15746-10)
Modified residuei2N-acetylalanineCombined sources1

Post-translational modificationi

Can probably be down-regulated by phosphorylation. Tyrosine phosphorylation by ABL1 increases kinase activity, reverses MLCK-mediated inhibition of Arp2/3-mediated actin polymerization, and enhances CTTN-binding. Phosphorylation by SRC at Tyr-464 and Tyr-471 promotes CTTN binding.3 Publications
The C-terminus is deglutamylated by AGTPBP1/CCP1, AGBL1/CCP4 and AGBL4/CCP6, leading to the formation of Myosin light chain kinase, smooth muscle, deglutamylated form. The consequences of C-terminal deglutamylation are unknown (By similarity).By similarity
Acetylated at Lys-608 by NAA10/ARD1 via a calcium-dependent signaling; this acetylation represses kinase activity and reduces tumor cell migration.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ15746
MaxQBiQ15746
PaxDbiQ15746
PeptideAtlasiQ15746
PRIDEiQ15746
ProteomicsDBi60733
60734 [Q15746-2]
60735 [Q15746-3]
60736 [Q15746-4]
60737 [Q15746-5]
60738 [Q15746-6]
60739 [Q15746-7]
60740 [Q15746-8]

PTM databases

iPTMnetiQ15746
PhosphoSitePlusiQ15746

Expressioni

Tissue specificityi

Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues. Accumulates in well differentiated enterocytes of the intestinal epithelium in response to tumor necrosis factor (TNF).4 Publications

Inductioni

Accumulates in individuals with asthma (at protein levels). Induced by tumor necrosis factor (TNF). Repressed by androgens (e.g. R1881).3 Publications

Gene expression databases

BgeeiENSG00000065534 Expressed in 242 organ(s), highest expression level in cauda epididymis
ExpressionAtlasiQ15746 baseline and differential
GenevisibleiQ15746 HS

Organism-specific databases

HPAiCAB020789
HPA031677
HPA048055

Interactioni

Subunit structurei

All isoforms including Telokin bind calmodulin. Interacts with SVIL (By similarity). Interacts with CTTN; this interaction is reduced during thrombin-induced endothelial cell (EC) contraction but is promoted by the barrier-protective agonist sphingosine 1-phosphate (S1P) within lamellipodia. A complex made of ABL1, CTTN and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Binds to NAA10/ARD1 and PTK2B/PYK2.By similarity6 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi110722, 17 interactors
CORUMiQ15746
IntActiQ15746, 23 interactors
MINTiQ15746
STRINGi9606.ENSP00000353452

Chemistry databases

BindingDBiQ15746

Structurei

Secondary structure

11914
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15746
SMRiQ15746
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15746

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 122Ig-like C2-type 1Add BLAST90
Domaini161 – 249Ig-like C2-type 2Add BLAST89
Domaini414 – 503Ig-like C2-type 3Add BLAST90
Domaini514 – 599Ig-like C2-type 4Add BLAST86
Domaini620 – 711Ig-like C2-type 5Add BLAST92
Domaini721 – 821Ig-like C2-type 6Add BLAST101
Repeati868 – 8951-1Add BLAST28
Repeati896 – 9231-2Add BLAST28
Repeati924 – 9511-3Add BLAST28
Repeati952 – 9791-4Add BLAST28
Repeati980 – 9981-5; truncatedAdd BLAST19
Repeati999 – 10032-1; truncated5
Repeati1004 – 10152-2Add BLAST12
Repeati1016 – 10272-3Add BLAST12
Repeati1028 – 10392-4Add BLAST12
Repeati1040 – 10512-5Add BLAST12
Repeati1052 – 10632-6Add BLAST12
Domaini1098 – 1186Ig-like C2-type 7Add BLAST89
Domaini1238 – 1326Ig-like C2-type 8Add BLAST89
Domaini1334 – 1426Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST93
Domaini1464 – 1719Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini1809 – 1898Ig-like C2-type 9Add BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni868 – 9985 X 28 AA approximate tandem repeatsAdd BLAST131
Regioni923 – 963Actin-binding (calcium/calmodulin-sensitive)By similarityAdd BLAST41
Regioni948 – 963Calmodulin-bindingBy similarityAdd BLAST16
Regioni999 – 10636 X 12 AA approximate tandem repeatsAdd BLAST65
Regioni1061 – 1460Actin-binding (calcium/calmodulin-insensitive)By similarityAdd BLAST400
Regioni1711 – 1774Calmodulin-bindingAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1906 – 1914Poly-Glu9

Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00760000118877
HOGENOMiHOG000049287
HOVERGENiHBG052552
InParanoidiQ15746
KOiK00907
OMAiKFIILSQ
OrthoDBiEOG091G005W
PhylomeDBiQ15746
TreeFamiTF314166

Family and domain databases

CDDicd00063 FN3, 1 hit
cd14191 STKc_MLCK1, 1 hit
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR015725 MLCK1_kinase_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 9 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 9 hits
SM00408 IGc2, 9 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48726 SSF48726, 9 hits
SSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (11+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 11 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15746-1) [UniParc]FASTAAdd to basket
Also known as: Non-muscle isozyme

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA 
        60         70         80         90        100
KFEGRVRGYP EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED 
       110        120        130        140        150
RGKYTCEATN GSGARQVTVE LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE 
       160        170        180        190        200
TRPSIWGECP PKFATKLGRV VVKEGQMGRF SCKITGRPQP QVTWLKGNVP 
       210        220        230        240        250
LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG KASMSAELSI 
       260        270        280        290        300
QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP 
       310        320        330        340        350
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA 
       360        370        380        390        400
RVQPEPRAPG LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN 
       410        420        430        440        450
RRIPMEGQRD SAFPKFESKP QSQEVKENQT VKFRCEVSGI PKPEVAWFLE 
       460        470        480        490        500
GTPVRRQEGS IEVYEDAGSH YLCLLKARTR DSGTYSCTAS NAQGQLSCSW 
       510        520        530        540        550
TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT PVPRITWLLN 
       560        570        580        590        600
GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV 
       610        620        630        640        650
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP 
       660        670        680        690        700
PPEVIWLHNG NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS 
       710        720        730        740        750
AGEVRTQAVL TVQEPHDGTQ PWFISKPRSV TASLGQSVLI SCAIAGDPFP 
       760        770        780        790        800
TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV LKKVQPWHAG QYEILLKNRV 
       810        820        830        840        850
GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG GGSDRYGSLR 
       860        870        880        890        900
PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL 
       910        920        930        940        950
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ 
       960        970        980        990       1000
VDFRSVLAKK GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA 
      1010       1020       1030       1040       1050
ETLNAKAVES SKPLSNAQPS GPLKPVGNAK PAETLKPMGN AKPAETLKPM 
      1060       1070       1080       1090       1100
GNAKPDENLK SASKEELKKD VKNDVNCKRG HAGTTDNEKR SESQGTAPAF 
      1110       1120       1130       1140       1150
KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT TKFIILSQEG 
      1160       1170       1180       1190       1200
SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE 
      1210       1220       1230       1240       1250
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR 
      1260       1270       1280       1290       1300
AGESVELFGK VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA 
      1310       1320       1330       1340       1350
RQEHCGCYTL LVENKLGSRQ AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL 
      1360       1370       1380       1390       1400
SWYGSSYDGG SAVQSYSIEI WDSANKTWKE LATCRSTSFN VQDLLPDHEY 
      1410       1420       1430       1440       1450
KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD DEKEPEVDYR 
      1460       1470       1480       1490       1500
TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA 
      1510       1520       1530       1540       1550
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI 
      1560       1570       1580       1590       1600
IDEDFELTER ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR 
      1610       1620       1630       1640       1650
IKLIDFGLAR RLENAGSLKV LFGTPEFVAP EVINYEPIGY ATDMWSIGVI 
      1660       1670       1680       1690       1700
CYILVSGLSP FMGDNDNETL ANVTSATWDF DDEAFDEISD DAKDFISNLL 
      1710       1720       1730       1740       1750
KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM ARRKWQKTGN 
      1760       1770       1780       1790       1800
AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV 
      1810       1820       1830       1840       1850
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR 
      1860       1870       1880       1890       1900
ESRHFQIDYD EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE 
      1910 
TMEEGEGEGE EEEE
Length:1,914
Mass (Da):210,715
Last modified:July 13, 2010 - v4
Checksum:i2D094E161CE2D4BA
GO
Isoform 2 (identifier: Q15746-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-506: VSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVER → G

Show »
Length:1,845
Mass (Da):203,055
Checksum:i0111D4C5A88349AB
GO
Isoform 3A (identifier: Q15746-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1655-1705: Missing.

Show »
Length:1,863
Mass (Da):205,059
Checksum:iA526210F1B9E546C
GO
Isoform 3B (identifier: Q15746-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-506: VSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVER → G
     1655-1705: Missing.

Show »
Length:1,794
Mass (Da):197,399
Checksum:i9EE35F5BADBB0D9A
GO
Isoform 4 (identifier: Q15746-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1473-1545: Missing.

Show »
Length:1,841
Mass (Da):202,350
Checksum:i23EDB48D1A11DE70
GO
Isoform Del-1790 (identifier: Q15746-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1790-1790: Missing.

Show »
Length:1,913
Mass (Da):210,586
Checksum:i6D3029D5CCA13B41
GO
Isoform 5 (identifier: Q15746-7) [UniParc]FASTAAdd to basket
Also known as: Smooth-muscle isozyme

The sequence of this isoform differs from the canonical sequence as follows:
     1-922: Missing.

Note: Transcribed from an alternative promoter resulting in the usage of Met-923 as initiator codon.1 Publication
Show »
Length:992
Mass (Da):110,205
Checksum:i27288359F94FE260
GO
Isoform 6 (identifier: Q15746-8) [UniParc]FASTAAdd to basket
Also known as: Telokin

The sequence of this isoform differs from the canonical sequence as follows:
     1-1760: Missing.

Note: Transcribed from an alternative promoter resulting in the usage of Met-1761 as initiator codon. Has no catalytic activity. Initiator Met is removed.Combined sources
Show »
Length:154
Mass (Da):16,970
Checksum:i0E3B6CAD36C563EE
GO
Isoform 7 (identifier: Q15746-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1200: Missing.

Note: No experimental confirmation available.
Show »
Length:714
Mass (Da):80,410
Checksum:i5C3E8AD06D8B855D
GO
Isoform 8 (identifier: Q15746-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1760: Missing.
     1790-1790: Missing.

Note: Transcribed from an alternative promoter resulting in the usage of Met-1761 as initiator codon. Initiator Met is removed.Combined sources
Show »
Length:153
Mass (Da):16,840
Checksum:iBF1292FFEB166F7B
GO
Isoform 9 (identifier: Q15746-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-922: Missing.
     1790-1790: Missing.

Note: Transcribed from an alternative promoter resulting in the usage of Met-923 as initiator codon.1 Publication
Show »
Length:991
Mass (Da):110,076
Checksum:iBCFD66306197E14C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9C2D6R9C2_HUMAN
Myosin light chain kinase, smooth m...
MYLK
229Annotation score:
F8WBL7F8WBL7_HUMAN
Myosin light chain kinase, smooth m...
MYLK
70Annotation score:

Sequence cautioni

The sequence AAD15922 differs from that shown. Reason: Frameshift at position 1433.Curated
Isoform 3A : The sequence AAD15922 differs from that shown. Reason: Frameshift at positions 1433 and 1439.Curated
The sequence AAD15923 differs from that shown. Reason: Frameshift at position 1433.Curated
Isoform 3B : The sequence AAD15923 differs from that shown. Reason: Frameshift at positions 1433 and 1439.Curated
The sequence AAD15924 differs from that shown. Reason: Frameshift at position 1433.Curated
Isoform 4 : The sequence AAD15924 differs from that shown. Reason: Frameshift at positions 1433 and 1439.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147P → S in AAC18423 (PubMed:9160829).Curated1
Sequence conflicti147P → S in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti147P → S in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti147P → S in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti147P → S in AAQ02673 (PubMed:15020676).Curated1
Sequence conflicti147P → S in EAW79438 (Ref. 11) Curated1
Sequence conflicti147P → S in EAW79440 (Ref. 11) Curated1
Sequence conflicti466D → N in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti496L → V in AAC18423 (PubMed:9160829).Curated1
Sequence conflicti496L → V in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti496L → V in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti496L → V in AAQ02673 (PubMed:15020676).Curated1
Sequence conflicti681C → W in AAC18423 (PubMed:9160829).Curated1
Sequence conflicti681C → W in AAD15921 (PubMed:10198165).Curated1
Sequence conflicti681C → W in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti681C → W in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti933V → M in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti963S → P in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1022P → A in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1048 – 1050KPM → EAH in CAA59685 (PubMed:8575746).Curated3
Sequence conflicti1048 – 1050KPM → EAH in BAB21504 (Ref. 8) Curated3
Sequence conflicti1162P → L in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1162P → L in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti1210L → P in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1280E → D in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1280E → D in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti1284M → I in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1284M → I in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti1284M → I in AAD15924 (PubMed:10198165).Curated1
Sequence conflicti1300A → G in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1316L → S in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1326T → S in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1478V → C in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1511S → T in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1511S → T in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti1518H → P in AAR29061 (PubMed:15507455).Curated1
Sequence conflicti1518H → P in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti1563I → T in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1609A → P in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1634N → I in AAR29061 (PubMed:15507455).Curated1
Sequence conflicti1634N → I in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti1639 – 1640GY → D in AAD15922 (PubMed:10198165).Curated2
Sequence conflicti1639 – 1640GY → D in AAD15923 (PubMed:10198165).Curated2
Sequence conflicti1639 – 1640GY → D in AAD15924 (PubMed:10198165).Curated2
Sequence conflicti1639G → R in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1648G → R in CAA59685 (PubMed:8575746).Curated1
Sequence conflicti1658 – 1659LS → PF in CAA59685 (PubMed:8575746).Curated2
Sequence conflicti1676A → P in AAR29061 (PubMed:15507455).Curated1
Sequence conflicti1676A → P in AAR29062 (PubMed:15507455).Curated1
Sequence conflicti1710 – 1711CT → LA in CAA59685 (PubMed:8575746).Curated2
Sequence conflicti1897L → H in AAD15922 (PubMed:10198165).Curated1
Sequence conflicti1897L → H in AAD15923 (PubMed:10198165).Curated1
Sequence conflicti1897L → H in AAD15924 (PubMed:10198165).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05710621P → H. Corresponds to variant dbSNP:rs28497577EnsemblClinVar.1
Natural variantiVAR_065570128A → V1 PublicationCorresponds to variant dbSNP:rs143896146EnsemblClinVar.1
Natural variantiVAR_065571133Q → H1 PublicationCorresponds to variant dbSNP:rs140148380EnsemblClinVar.1
Natural variantiVAR_065572160P → R1 PublicationCorresponds to variant dbSNP:rs111256888EnsemblClinVar.1
Natural variantiVAR_040847261V → A1 PublicationCorresponds to variant dbSNP:rs3796164EnsemblClinVar.1
Natural variantiVAR_040848276T → A1 PublicationCorresponds to variant dbSNP:rs55846245Ensembl.1
Natural variantiVAR_057107336P → L. Corresponds to variant dbSNP:rs35912339EnsemblClinVar.1
Natural variantiVAR_040849378R → H1 PublicationCorresponds to variant dbSNP:rs56378658EnsemblClinVar.1
Natural variantiVAR_040850405M → V1 PublicationCorresponds to variant dbSNP:rs35436690EnsemblClinVar.1
Natural variantiVAR_040851443P → S1 PublicationCorresponds to variant dbSNP:rs35156360EnsemblClinVar.1
Natural variantiVAR_040852607R → G1 Publication1
Natural variantiVAR_040853652P → A1 PublicationCorresponds to variant dbSNP:rs750686734Ensembl.1
Natural variantiVAR_040854656W → C2 PublicationsCorresponds to variant dbSNP:rs138172035EnsemblClinVar.1
Natural variantiVAR_040855692T → M1 PublicationCorresponds to variant dbSNP:rs776858093Ensembl.1
Natural variantiVAR_040856701A → T1 PublicationCorresponds to variant dbSNP:rs142835596EnsemblClinVar.1
Natural variantiVAR_040857709V → M1 PublicationCorresponds to variant dbSNP:rs112537316EnsemblClinVar.1
Natural variantiVAR_057108845R → C. Corresponds to variant dbSNP:rs3732485EnsemblClinVar.1
Natural variantiVAR_019986861L → P. Corresponds to variant dbSNP:rs3732486EnsemblClinVar.1
Natural variantiVAR_057109877V → M. Corresponds to variant dbSNP:rs34542174EnsemblClinVar.1
Natural variantiVAR_019987914D → E. Corresponds to variant dbSNP:rs3732487EnsemblClinVar.1
Natural variantiVAR_0655731085T → A1 PublicationCorresponds to variant dbSNP:rs75370906EnsemblClinVar.1
Natural variantiVAR_0655741213V → M in AAT7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs368390254EnsemblClinVar.1
Natural variantiVAR_0655751399E → K1 PublicationCorresponds to variant dbSNP:rs181663420EnsemblClinVar.1
Natural variantiVAR_0408581527A → V1 PublicationCorresponds to variant dbSNP:rs34982967Ensembl.1
Natural variantiVAR_0408591588P → L in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0655761754A → T in AAT7; 4-fold reduced affinity for calmodulin; decreased kinase activity compared to wild-type protein. 1 Publication1
Natural variantiVAR_0655771759S → P in AAT7; 7-fold reduced affinity for calmodulin; 6-fold decreased Vmax. 1 PublicationCorresponds to variant dbSNP:rs387906781EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188461 – 1760Missing in isoform 6 and isoform 8. 3 PublicationsAdd BLAST1760
Alternative sequenceiVSP_0537911 – 1200Missing in isoform 7. 1 PublicationAdd BLAST1200
Alternative sequenceiVSP_0188451 – 922Missing in isoform 5 and isoform 9. 2 PublicationsAdd BLAST922
Alternative sequenceiVSP_004791437 – 506VSGIP…LQVER → G in isoform 2 and isoform 3B. 2 PublicationsAdd BLAST70
Alternative sequenceiVSP_0047931473 – 1545Missing in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_0047941655 – 1705Missing in isoform 3A and isoform 3B. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_0047951790Missing in isoform Del-1790, isoform 8 and isoform 9. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85337 mRNA Translation: CAA59685.1
U48959 mRNA Translation: AAC18423.2
AF069601 mRNA Translation: AAD15921.2
AF069602 mRNA Translation: AAD15922.1 Frameshift.
AF069603 mRNA Translation: AAD15923.1 Frameshift.
AF069604 mRNA Translation: AAD15924.1 Frameshift.
AF096771
, AF096766, AF096767, AF096768, AF096769, AF096770 Genomic DNA Translation: AAD51380.1
AF096771, AF096769, AF096770 Genomic DNA Translation: AAD51381.1
AF096773 mRNA Translation: AAD54017.1
AF096774 mRNA Translation: AAD54018.1
AF096775 mRNA Translation: AAD54019.1
AY424269 mRNA Translation: AAR29061.1
AY424270 mRNA Translation: AAR29062.1
AY339601 mRNA Translation: AAQ02673.1
AB037663 mRNA Translation: BAB21504.1
AK300610 mRNA Translation: BAG62305.1
AK314412 mRNA Translation: BAG37033.1
AK314443 mRNA Translation: BAG37052.1
AC020634 Genomic DNA No translation available.
AC023165 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79438.1
CH471052 Genomic DNA Translation: EAW79439.1
CH471052 Genomic DNA Translation: EAW79440.1
CH471052 Genomic DNA Translation: EAW79441.1
BC100761 mRNA Translation: AAI00762.2
BC100762 mRNA Translation: AAI00763.2
BC100763 mRNA Translation: AAI00764.2
BC064420 mRNA Translation: AAH64420.2
X90870 mRNA Translation: CAA62378.1
CCDSiCCDS3023.1 [Q15746-3]
CCDS43141.1 [Q15746-2]
CCDS46896.1 [Q15746-1]
CCDS46897.1 [Q15746-8]
CCDS58849.1 [Q15746-10]
RefSeqiNP_001308238.1, NM_001321309.1
NP_444253.3, NM_053025.3 [Q15746-1]
NP_444254.3, NM_053026.3 [Q15746-2]
NP_444255.3, NM_053027.3 [Q15746-3]
NP_444256.3, NM_053028.3 [Q15746-4]
NP_444259.1, NM_053031.3 [Q15746-10]
NP_444260.1, NM_053032.3 [Q15746-8]
XP_011511162.1, XM_011512860.2
XP_016861958.1, XM_017006469.1 [Q15746-11]
XP_016861960.1, XM_017006471.1 [Q15746-9]
XP_016861961.1, XM_017006472.1 [Q15746-8]
XP_016861962.1, XM_017006473.1 [Q15746-10]
UniGeneiHs.477375

Genome annotation databases

EnsembliENST00000346322; ENSP00000320622; ENSG00000065534 [Q15746-2]
ENST00000354792; ENSP00000346846; ENSG00000065534 [Q15746-2]
ENST00000359169; ENSP00000352088; ENSG00000065534 [Q15746-3]
ENST00000360304; ENSP00000353452; ENSG00000065534 [Q15746-1]
ENST00000360772; ENSP00000354004; ENSG00000065534 [Q15746-3]
ENST00000418370; ENSP00000428967; ENSG00000065534 [Q15746-8]
ENST00000475616; ENSP00000418335; ENSG00000065534 [Q15746-1]
ENST00000578202; ENSP00000463691; ENSG00000065534 [Q15746-10]
ENST00000583087; ENSP00000462118; ENSG00000065534 [Q15746-8]
GeneIDi4638
KEGGihsa:4638
UCSCiuc003egl.4 human [Q15746-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Myosin light-chain kinase entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85337 mRNA Translation: CAA59685.1
U48959 mRNA Translation: AAC18423.2
AF069601 mRNA Translation: AAD15921.2
AF069602 mRNA Translation: AAD15922.1 Frameshift.
AF069603 mRNA Translation: AAD15923.1 Frameshift.
AF069604 mRNA Translation: AAD15924.1 Frameshift.
AF096771
, AF096766, AF096767, AF096768, AF096769, AF096770 Genomic DNA Translation: AAD51380.1
AF096771, AF096769, AF096770 Genomic DNA Translation: AAD51381.1
AF096773 mRNA Translation: AAD54017.1
AF096774 mRNA Translation: AAD54018.1
AF096775 mRNA Translation: AAD54019.1
AY424269 mRNA Translation: AAR29061.1
AY424270 mRNA Translation: AAR29062.1
AY339601 mRNA Translation: AAQ02673.1
AB037663 mRNA Translation: BAB21504.1
AK300610 mRNA Translation: BAG62305.1
AK314412 mRNA Translation: BAG37033.1
AK314443 mRNA Translation: BAG37052.1
AC020634 Genomic DNA No translation available.
AC023165 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79438.1
CH471052 Genomic DNA Translation: EAW79439.1
CH471052 Genomic DNA Translation: EAW79440.1
CH471052 Genomic DNA Translation: EAW79441.1
BC100761 mRNA Translation: AAI00762.2
BC100762 mRNA Translation: AAI00763.2
BC100763 mRNA Translation: AAI00764.2
BC064420 mRNA Translation: AAH64420.2
X90870 mRNA Translation: CAA62378.1
CCDSiCCDS3023.1 [Q15746-3]
CCDS43141.1 [Q15746-2]
CCDS46896.1 [Q15746-1]
CCDS46897.1 [Q15746-8]
CCDS58849.1 [Q15746-10]
RefSeqiNP_001308238.1, NM_001321309.1
NP_444253.3, NM_053025.3 [Q15746-1]
NP_444254.3, NM_053026.3 [Q15746-2]
NP_444255.3, NM_053027.3 [Q15746-3]
NP_444256.3, NM_053028.3 [Q15746-4]
NP_444259.1, NM_053031.3 [Q15746-10]
NP_444260.1, NM_053032.3 [Q15746-8]
XP_011511162.1, XM_011512860.2
XP_016861958.1, XM_017006469.1 [Q15746-11]
XP_016861960.1, XM_017006471.1 [Q15746-9]
XP_016861961.1, XM_017006472.1 [Q15746-8]
XP_016861962.1, XM_017006473.1 [Q15746-10]
UniGeneiHs.477375

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQVNMR-A1238-1338[»]
2K0FNMR-B1742-1760[»]
2YR3NMR-A510-601[»]
5JQAX-ray1.80B1742-1761[»]
5JTHX-ray1.84B1742-1761[»]
ProteinModelPortaliQ15746
SMRiQ15746
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110722, 17 interactors
CORUMiQ15746
IntActiQ15746, 23 interactors
MINTiQ15746
STRINGi9606.ENSP00000353452

Chemistry databases

BindingDBiQ15746
ChEMBLiCHEMBL2428
GuidetoPHARMACOLOGYi1552

PTM databases

iPTMnetiQ15746
PhosphoSitePlusiQ15746

Polymorphism and mutation databases

BioMutaiMYLK
DMDMi300669714

Proteomic databases

EPDiQ15746
MaxQBiQ15746
PaxDbiQ15746
PeptideAtlasiQ15746
PRIDEiQ15746
ProteomicsDBi60733
60734 [Q15746-2]
60735 [Q15746-3]
60736 [Q15746-4]
60737 [Q15746-5]
60738 [Q15746-6]
60739 [Q15746-7]
60740 [Q15746-8]

Protocols and materials databases

DNASUi4638
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346322; ENSP00000320622; ENSG00000065534 [Q15746-2]
ENST00000354792; ENSP00000346846; ENSG00000065534 [Q15746-2]
ENST00000359169; ENSP00000352088; ENSG00000065534 [Q15746-3]
ENST00000360304; ENSP00000353452; ENSG00000065534 [Q15746-1]
ENST00000360772; ENSP00000354004; ENSG00000065534 [Q15746-3]
ENST00000418370; ENSP00000428967; ENSG00000065534 [Q15746-8]
ENST00000475616; ENSP00000418335; ENSG00000065534 [Q15746-1]
ENST00000578202; ENSP00000463691; ENSG00000065534 [Q15746-10]
ENST00000583087; ENSP00000462118; ENSG00000065534 [Q15746-8]
GeneIDi4638
KEGGihsa:4638
UCSCiuc003egl.4 human [Q15746-1]

Organism-specific databases

CTDi4638
DisGeNETi4638
EuPathDBiHostDB:ENSG00000065534.18
GeneCardsiMYLK
GeneReviewsiMYLK
HGNCiHGNC:7590 MYLK
HPAiCAB020789
HPA031677
HPA048055
MalaCardsiMYLK
MIMi600922 gene
613780 phenotype
neXtProtiNX_Q15746
OpenTargetsiENSG00000065534
Orphaneti91387 Familial thoracic aortic aneurysm and aortic dissection
PharmGKBiPA31388
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00760000118877
HOGENOMiHOG000049287
HOVERGENiHBG052552
InParanoidiQ15746
KOiK00907
OMAiKFIILSQ
OrthoDBiEOG091G005W
PhylomeDBiQ15746
TreeFamiTF314166

Enzyme and pathway databases

BRENDAi2.7.11.18 2681
ReactomeiR-HSA-445355 Smooth Muscle Contraction
R-HSA-5627123 RHO GTPases activate PAKs
SABIO-RKiQ15746
SignaLinkiQ15746
SIGNORiQ15746

Miscellaneous databases

ChiTaRSiMYLK human
EvolutionaryTraceiQ15746
GeneWikiiMYLK
GenomeRNAii4638
PROiPR:Q15746
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065534 Expressed in 242 organ(s), highest expression level in cauda epididymis
ExpressionAtlasiQ15746 baseline and differential
GenevisibleiQ15746 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
cd14191 STKc_MLCK1, 1 hit
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR015725 MLCK1_kinase_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 9 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 9 hits
SM00408 IGc2, 9 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48726 SSF48726, 9 hits
SSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYLK_HUMAN
AccessioniPrimary (citable) accession number: Q15746
Secondary accession number(s): B4DUE3
, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 13, 2010
Last modified: October 10, 2018
This is version 202 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  8. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
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