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Protein

Ovarian cancer G-protein coupled receptor 1

Gene

GPR68

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).By similarity1 Publication

Caution

Was originally (PubMed:10806476) thought to be a receptor for sphingosylphosphorylcholine (SPC). However, this work has been retracted (PubMed:16508674).2 Publications

GO - Molecular functioni

  • G protein-coupled receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Ovarian cancer G-protein coupled receptor 1
Short name:
OGR-1
Alternative name(s):
G-protein coupled receptor 68
GPR12A
Sphingosylphosphorylcholine receptor
Gene namesi
Name:GPR68
Synonyms:OGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000119714.10
HGNCiHGNC:4519 GPR68
MIMi601404 gene
neXtProtiNX_Q15743

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 46Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini47 – 58CytoplasmicSequence analysisAdd BLAST12
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 95ExtracellularSequence analysisAdd BLAST15
Transmembranei96 – 117Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini118 – 136CytoplasmicSequence analysisAdd BLAST19
Transmembranei137 – 158Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini159 – 183ExtracellularSequence analysisAdd BLAST25
Transmembranei184 – 205Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini206 – 228CytoplasmicSequence analysisAdd BLAST23
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 263ExtracellularSequence analysisAdd BLAST14
Transmembranei264 – 284Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini285 – 365CytoplasmicSequence analysisAdd BLAST81

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
See also OMIM:617217
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07787474L → P in AI2A6. 1 PublicationCorresponds to variant dbSNP:rs1057517672Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi17H → F: Failed to stimulate IP formation at pH 6.8, activity is restored at more acid pH. 1 Publication1
Mutagenesisi20H → F: Failed to stimulate IP formation at pH 6.8, activity is restored at more acid pH. 1 Publication1
Mutagenesisi84H → F: Failed to stimulate IP formation at pH 6.8, activity is restored at more acid pH. 1 Publication1
Mutagenesisi89H → F: No effect on pH-sensing activity. 1 Publication1
Mutagenesisi159H → F: No effect on pH-sensing activity. 1 Publication1
Mutagenesisi169H → F: Failed to stimulate IP formation at pH 6.8, activity is restored at more acid pH. 1
Mutagenesisi175H → F: No effect on pH-sensing activity. 1 Publication1
Mutagenesisi245H → F: Severe loss pH-sensing activity. 1 Publication1
Mutagenesisi269H → F: Failed to stimulate IP formation at pH 6.8, activity is restored at more acid pH. 1 Publication1

Keywords - Diseasei

Amelogenesis imperfecta, Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNETi8111
MalaCardsiGPR68
MIMi617217 phenotype
OpenTargetsiENSG00000119714
Orphaneti100033 Hypomaturation amelogenesis imperfecta
PharmGKBiPA28911

Chemistry databases

ChEMBLiCHEMBL3713916
GuidetoPHARMACOLOGYi114

Polymorphism and mutation databases

BioMutaiGPR68
DMDMi3024266

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701131 – 365Ovarian cancer G-protein coupled receptor 1Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15743
PeptideAtlasiQ15743
PRIDEiQ15743
ProteomicsDBi60731

PTM databases

iPTMnetiQ15743
PhosphoSitePlusiQ15743
SwissPalmiQ15743

Expressioni

Tissue specificityi

Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.1 Publication

Gene expression databases

BgeeiENSG00000119714 Expressed in 160 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_GPR68
ExpressionAtlasiQ15743 baseline and differential
GenevisibleiQ15743 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000434045

Chemistry databases

BindingDBiQ15743

Structurei

3D structure databases

ProteinModelPortaliQ15743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH5V Eukaryota
ENOG410Z8KI LUCA
GeneTreeiENSGT00920000148955
HOGENOMiHOG000004801
InParanoidiQ15743
KOiK08408
OMAiDRHRVCF
OrthoDBiEOG091G06ZG
PhylomeDBiQ15743
TreeFamiTF331803

Family and domain databases

CDDicd15367 7tmA_GPR68_OGR1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005389 OGR1_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01564 OGR1RECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15743-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNITADNSS MSCTIDHTIH QTLAPVVYVT VLVVGFPANC LSLYFGYLQI
60 70 80 90 100
KARNELGVYL CNLTVADLFY ICSLPFWLQY VLQHDNWSHG DLSCQVCGIL
110 120 130 140 150
LYENIYISVG FLCCISVDRY LAVAHPFRFH QFRTLKAAVG VSVVIWAKEL
160 170 180 190 200
LTSIYFLMHE EVIEDENQHR VCFEHYPIQA WQRAINYYRF LVGFLFPICL
210 220 230 240 250
LLASYQGILR AVRRSHGTQK SRKDQIQRLV LSTVVIFLAC FLPYHVLLLV
260 270 280 290 300
RSVWEASCDF AKGVFNAYHF SLLLTSFNCV ADPVLYCFVS ETTHRDLARL
310 320 330 340 350
RGACLAFLTC SRTGRAREAY PLGAPEASGK SGAQGEEPEL LTKLHPAFQT
360
PNSPGSGGFP TGRLA
Length:365
Mass (Da):41,077
Last modified:November 1, 1996 - v1
Checksum:i05919AFD5B842CCD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNU7E9PNU7_HUMAN
Ovarian cancer G-protein-coupled re...
GPR68
338Annotation score:

Sequence cautioni

The sequence AAH96071 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH96072 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH96073 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH96074 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH98567 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAT38917 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ACG60649 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW81447 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140 – 142GVS → RVT in AAA79060 (PubMed:7498459).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06471639N → S Found in a renal cell carcinoma case; somatic mutation. 1 Publication1
Natural variantiVAR_05871453R → Q. Corresponds to variant dbSNP:rs2230339Ensembl.1
Natural variantiVAR_07787474L → P in AI2A6. 1 PublicationCorresponds to variant dbSNP:rs1057517672Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35398 mRNA Translation: AAA79060.1
U48405 Genomic DNA Translation: AAC50596.1
EU883575 mRNA Translation: ACG60649.1 Different initiation.
AY615372 mRNA Translation: AAT38917.1 Different initiation.
AL135818 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81447.1 Different initiation.
BC067472 mRNA Translation: AAH67472.1
BC069592 mRNA Translation: AAH69592.1
BC096071 mRNA Translation: AAH96071.1 Different initiation.
BC096072 mRNA Translation: AAH96072.1 Different initiation.
BC096073 mRNA Translation: AAH96073.1 Different initiation.
BC096074 mRNA Translation: AAH96074.1 Different initiation.
BC098567 mRNA Translation: AAH98567.1 Different initiation.
CCDSiCCDS9894.2
PIRiS68208
RefSeqiNP_001171147.1, NM_001177676.1
NP_001335366.1, NM_001348437.1
NP_003476.3, NM_003485.3
XP_005268167.1, XM_005268110.4
XP_005268168.1, XM_005268111.3
XP_005268169.1, XM_005268112.3
XP_006720325.1, XM_006720262.3
XP_011535498.1, XM_011537196.2
XP_011535499.1, XM_011537197.2
XP_011535500.1, XM_011537198.2
XP_011535501.1, XM_011537199.2
UniGeneiHs.8882

Genome annotation databases

EnsembliENST00000531499; ENSP00000434045; ENSG00000119714
ENST00000535815; ENSP00000440797; ENSG00000119714
GeneIDi8111
KEGGihsa:8111
UCSCiuc001xzg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35398 mRNA Translation: AAA79060.1
U48405 Genomic DNA Translation: AAC50596.1
EU883575 mRNA Translation: ACG60649.1 Different initiation.
AY615372 mRNA Translation: AAT38917.1 Different initiation.
AL135818 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81447.1 Different initiation.
BC067472 mRNA Translation: AAH67472.1
BC069592 mRNA Translation: AAH69592.1
BC096071 mRNA Translation: AAH96071.1 Different initiation.
BC096072 mRNA Translation: AAH96072.1 Different initiation.
BC096073 mRNA Translation: AAH96073.1 Different initiation.
BC096074 mRNA Translation: AAH96074.1 Different initiation.
BC098567 mRNA Translation: AAH98567.1 Different initiation.
CCDSiCCDS9894.2
PIRiS68208
RefSeqiNP_001171147.1, NM_001177676.1
NP_001335366.1, NM_001348437.1
NP_003476.3, NM_003485.3
XP_005268167.1, XM_005268110.4
XP_005268168.1, XM_005268111.3
XP_005268169.1, XM_005268112.3
XP_006720325.1, XM_006720262.3
XP_011535498.1, XM_011537196.2
XP_011535499.1, XM_011537197.2
XP_011535500.1, XM_011537198.2
XP_011535501.1, XM_011537199.2
UniGeneiHs.8882

3D structure databases

ProteinModelPortaliQ15743
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000434045

Chemistry databases

BindingDBiQ15743
ChEMBLiCHEMBL3713916
GuidetoPHARMACOLOGYi114

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ15743
PhosphoSitePlusiQ15743
SwissPalmiQ15743

Polymorphism and mutation databases

BioMutaiGPR68
DMDMi3024266

Proteomic databases

PaxDbiQ15743
PeptideAtlasiQ15743
PRIDEiQ15743
ProteomicsDBi60731

Protocols and materials databases

DNASUi8111
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000531499; ENSP00000434045; ENSG00000119714
ENST00000535815; ENSP00000440797; ENSG00000119714
GeneIDi8111
KEGGihsa:8111
UCSCiuc001xzg.4 human

Organism-specific databases

CTDi8111
DisGeNETi8111
EuPathDBiHostDB:ENSG00000119714.10
GeneCardsiGPR68
HGNCiHGNC:4519 GPR68
MalaCardsiGPR68
MIMi601404 gene
617217 phenotype
neXtProtiNX_Q15743
OpenTargetsiENSG00000119714
Orphaneti100033 Hypomaturation amelogenesis imperfecta
PharmGKBiPA28911
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH5V Eukaryota
ENOG410Z8KI LUCA
GeneTreeiENSGT00920000148955
HOGENOMiHOG000004801
InParanoidiQ15743
KOiK08408
OMAiDRHRVCF
OrthoDBiEOG091G06ZG
PhylomeDBiQ15743
TreeFamiTF331803

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

GeneWikiiGPR68
GenomeRNAii8111
PROiPR:Q15743
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119714 Expressed in 160 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_GPR68
ExpressionAtlasiQ15743 baseline and differential
GenevisibleiQ15743 HS

Family and domain databases

CDDicd15367 7tmA_GPR68_OGR1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005389 OGR1_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01564 OGR1RECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOGR1_HUMAN
AccessioniPrimary (citable) accession number: Q15743
Secondary accession number(s): Q13334, Q4VBB4, Q6IX34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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