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UniProtKB - Q15735 (PI5PA_HUMAN)

Entry version 173 (07 Apr 2021)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
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Protein

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Gene

INPP5J

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS11950-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15735

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-1855183, Synthesis of IP2, IP, and Ins in the cytosol
R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC:3.1.3.56)
Alternative name(s):
Inositol polyphosphate 5-phosphatase J
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INPP5J
Synonyms:PIB5PA, PIPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8956, INPP5J

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606481, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15735

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000185133.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		27124

Open Targets

More...OpenTargetsi		ENSG00000185133

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164720918

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15735, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		INPP5J

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242713

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002097381 – 1006Phosphatidylinositol 4,5-bisphosphate 5-phosphatase AAdd BLAST1006

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei56Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei56Omega-N-methylarginine; alternateBy similarity1
Modified residuei65Omega-N-methylarginineBy similarity1
Modified residuei76Asymmetric dimethylarginineBy similarity1
Modified residuei83Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei83Omega-N-methylarginine; alternateBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei903PhosphoserineCombined sources1
Modified residuei990PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15735

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15735

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15735

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15735

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15735

PeptideAtlas

More...PeptideAtlasi		Q15735

PRoteomics IDEntifications database

More...PRIDEi		Q15735

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60724 [Q15735-1]
60725 [Q15735-2]
60726 [Q15735-3]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		INPP5J

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15735

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15735

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185133, Expressed in right lobe of thyroid gland and 150 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15735, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15735, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185133, Tissue enhanced (parathyroid gland, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118015, 18 interactors

Protein interaction database and analysis system

More...IntActi		Q15735, 18 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000333262

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15735, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15735

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni425 – 728CatalyticSequence analysisAdd BLAST304
Regioni729 – 840Required for ruffle localizationBy similarityAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi102 – 107RSXSXX motif 16
Motifi345 – 350SH3-bindingSequence analysis6
Motifi350 – 355RSXSXX motif 26
Motifi874 – 879RSXSXX motif 36
Motifi885 – 890RSXSXX motif 46
Motifi911 – 916RSXSXX motif 56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi122 – 371Pro-richAdd BLAST250
Compositional biasi840 – 937Ser-richAdd BLAST98

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.Curated

Keywords - Domaini

Repeat, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0565, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156855

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15735

Identification of Orthologs from Complete Genome Data

More...OMAi		CRSDPGF

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15735

TreeFam database of animal gene trees

More...TreeFami		TF317034

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000300, IPPc
IPR041611, SKICH

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03372, Exo_endo_phos, 1 hit
PF17751, SKICH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00128, IPPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56219, SSF56219, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15735-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGQSSRGSR RPGTRAGLGS LPMPQGVAQT GAPSKVDSSF QLPAKKNAAL 
        60         70         80         90        100
GPSEPRLALA PVGPRAAMSA SSEGPRLALA SPRPILAPLC TPEGQKTATA 
       110        120        130        140        150
HRSSSLAPTS VGQLVMSASA GPKPPPATTG SVLAPTSLGL VMPASAGPRS 
       160        170        180        190        200
PPVTLGPNLA PTSRDQKQEP PASVGPKPTL AASGLSLALA SEEQPPELPS 
       210        220        230        240        250
TPSPVPSPVL SPTQEQALAP ASTASGAASV GQTSARKRDA PAPRPLPASE 
       260        270        280        290        300
GHLQPPAQTS GPTGSPPCIQ TSPDPRLSPS FRARPEALHS SPEDPVLPRP 
       310        320        330        340        350
PQTLPLDVGQ GPSEPGTHSP GLLSPTFRPG APSGQTVPPP LPKPPRSPSR 
       360        370        380        390        400
SPSHSPNRSP CVPPAPDMAL PRLGTQSTGP GRCLSPNLQA QEAPAPVTTS 
       410        420        430        440        450
SSTSTLSSSP WSAQPTWKSD PGFRITVVTW NVGTAMPPDD VTSLLHLGGG 
       460        470        480        490        500
DDSDGADMIA IGLQEVNSML NKRLKDALFT DQWSELFMDA LGPFNFVLVS 
       510        520        530        540        550
SVRMQGVILL LFAKYYHLPF LRDVQTDCTR TGLGGYWGNK GGVSVRLAAF 
       560        570        580        590        600
GHMLCFLNCH LPAHMDKAEQ RKDNFQTILS LQQFQGPGAQ GILDHDLVFW 
       610        620        630        640        650
FGDLNFRIES YDLHFVKFAI DSDQLHQLWE KDQLNMAKNT WPILKGFQEG 
       660        670        680        690        700
PLNFAPTFKF DVGTNKYDTS AKKRKPAWTD RILWKVKAPG GGPSPSGRKS 
       710        720        730        740        750
HRLQVTQHSY RSHMEYTVSD HKPVAAQFLL QFAFRDDMPL VRLEVADEWV 
       760        770        780        790        800
RPEQAVVRYR METVFARSSW DWIGLYRVGF RHCKDYVAYV WAKHEDVDGN 
       810        820        830        840        850
TYQVTFSEES LPKGHGDFIL GYYSHNHSIL IGITEPFQIS LPSSELASSS 
       860        870        880        890        900
TDSSGTSSEG EDDSTLELLA PKSRSPSPGK SKRHRSRSPG LARFPGLALR 
       910        920        930        940        950
PSSRERRGAS RSPSPQSRRL SRVAPDRSSN GSSRGSSEEG PSGLPGPWAF 
       960        970        980        990       1000
PPAVPRSLGL LPALRLETVD PGGGGSWGPD REALAPNSLS PSPQGHRGLE 

EGGLGP
Length:1,006
Mass (Da):107,197
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADB6382AA33E15AC
GO
Isoform 2 (identifier: Q15735-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-367: Missing.

Show »
Length:639
Mass (Da):70,464
Checksum:i3ED5CD8BBB3398D0
GO
Isoform 3 (identifier: Q15735-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-423: Missing.

Show »
Length:638
Mass (Da):70,239
Checksum:i3F8ECF77ECC71C26
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVS7A0A087WVS7_HUMAN
Inositol-polyphosphate 5-phosphatas...
INPP5J
571Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DF95B4DF95_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
939Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MBZ3B5MBZ3_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
371Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCL8B5MCL8_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
345Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0M5C9K0M5_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0H5C9J0H5_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD15618 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti610 – 612SYD → ARG (Ref. 5) Curated3
Sequence conflicti662V → A in BAC86611 (PubMed:14702039).Curated1
Sequence conflicti791W → R in AAI09289 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028107333S → I. Corresponds to variant dbSNP:rs12485025Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0072961 – 367Missing in isoform 2. 2 PublicationsAdd BLAST367
Alternative sequenceiVSP_02101756 – 423Missing in isoform 3. 1 PublicationAdd BLAST368

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK092859 mRNA Translation: BAG52616.1
AK095944 mRNA Translation: BAC04657.1
AK126610 mRNA Translation: BAC86611.1
AC005005 Genomic DNA Translation: AAD15618.1 Sequence problems.
CH471095 Genomic DNA Translation: EAW59936.1
BC109288 mRNA Translation: AAI09289.1
U45975 mRNA Translation: AAB03216.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46687.1 [Q15735-3]
CCDS63453.1 [Q15735-1]
CCDS63455.1 [Q15735-2]

NCBI Reference Sequences

More...RefSeqi		NP_001002837.1, NM_001002837.2 [Q15735-3]
NP_001271214.1, NM_001284285.1 [Q15735-1]
NP_001271217.1, NM_001284288.1 [Q15735-2]
NP_001271218.1, NM_001284289.1 [Q15735-2]
XP_016884260.1, XM_017028771.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000331075; ENSP00000333262; ENSG00000185133 [Q15735-1]
ENST00000400294; ENSP00000383150; ENSG00000185133 [Q15735-2]
ENST00000404390; ENSP00000384534; ENSG00000185133 [Q15735-3]
ENST00000405300; ENSP00000384596; ENSG00000185133 [Q15735-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27124

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27124

UCSC genome browser

More...UCSCi		uc003ajs.5, human [Q15735-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092859 mRNA Translation: BAG52616.1
AK095944 mRNA Translation: BAC04657.1
AK126610 mRNA Translation: BAC86611.1
AC005005 Genomic DNA Translation: AAD15618.1 Sequence problems.
CH471095 Genomic DNA Translation: EAW59936.1
BC109288 mRNA Translation: AAI09289.1
U45975 mRNA Translation: AAB03216.1
CCDSiCCDS46687.1 [Q15735-3]
CCDS63453.1 [Q15735-1]
CCDS63455.1 [Q15735-2]
RefSeqiNP_001002837.1, NM_001002837.2 [Q15735-3]
NP_001271214.1, NM_001284285.1 [Q15735-1]
NP_001271217.1, NM_001284288.1 [Q15735-2]
NP_001271218.1, NM_001284289.1 [Q15735-2]
XP_016884260.1, XM_017028771.1

3D structure databases

SMRiQ15735
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118015, 18 interactors
IntActiQ15735, 18 interactors
STRINGi9606.ENSP00000333262

PTM databases

DEPODiINPP5J
iPTMnetiQ15735
PhosphoSitePlusiQ15735

Genetic variation databases

BioMutaiINPP5J
DMDMi116242713

Proteomic databases

EPDiQ15735
jPOSTiQ15735
MassIVEiQ15735
MaxQBiQ15735
PaxDbiQ15735
PeptideAtlasiQ15735
PRIDEiQ15735
ProteomicsDBi60724 [Q15735-1]
60725 [Q15735-2]
60726 [Q15735-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		5745, 201 antibodies

Genome annotation databases

EnsembliENST00000331075; ENSP00000333262; ENSG00000185133 [Q15735-1]
ENST00000400294; ENSP00000383150; ENSG00000185133 [Q15735-2]
ENST00000404390; ENSP00000384534; ENSG00000185133 [Q15735-3]
ENST00000405300; ENSP00000384596; ENSG00000185133 [Q15735-2]
GeneIDi27124
KEGGihsa:27124
UCSCiuc003ajs.5, human [Q15735-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27124
DisGeNETi27124

GeneCards: human genes, protein and diseases

More...GeneCardsi		INPP5J
HGNCiHGNC:8956, INPP5J
HPAiENSG00000185133, Tissue enhanced (parathyroid gland, thyroid gland)
MIMi606481, gene
neXtProtiNX_Q15735
OpenTargetsiENSG00000185133
PharmGKBiPA164720918
VEuPathDBiHostDB:ENSG00000185133.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0565, Eukaryota
GeneTreeiENSGT00940000156855
InParanoidiQ15735
OMAiCRSDPGF
PhylomeDBiQ15735
TreeFamiTF317034

Enzyme and pathway databases

BioCyciMetaCyc:HS11950-MONOMER
PathwayCommonsiQ15735
ReactomeiR-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-1855183, Synthesis of IP2, IP, and Ins in the cytosol
R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27124, 5 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		INPP5J, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PIB5PA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27124
PharosiQ15735, Tbio

Protein Ontology

More...PROi		PR:Q15735
RNActiQ15735, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185133, Expressed in right lobe of thyroid gland and 150 other tissues
ExpressionAtlasiQ15735, baseline and differential
GenevisibleiQ15735, HS

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000300, IPPc
IPR041611, SKICH
PfamiView protein in Pfam
PF03372, Exo_endo_phos, 1 hit
PF17751, SKICH, 1 hit
SMARTiView protein in SMART
SM00128, IPPc, 1 hit
SUPFAMiSSF56219, SSF56219, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI5PA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15735
Secondary accession number(s): B3KS54
, Q32M61, Q6ZTH6, Q8N902, Q9UDT9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 17, 2006
Last modified: April 7, 2021
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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