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Protein

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Gene

INPP5J

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS11950-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC:3.1.3.56)
Alternative name(s):
Inositol polyphosphate 5-phosphatase J
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INPP5J
Synonyms:PIB5PA, PIPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000185133.13

Human Gene Nomenclature Database

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HGNCi
HGNC:8956 INPP5J

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606481 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15735

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27124

Open Targets

More...
OpenTargetsi
ENSG00000185133

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164720918

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242713

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002097381 – 1006Phosphatidylinositol 4,5-bisphosphate 5-phosphatase AAdd BLAST1006

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei56Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei56Omega-N-methylarginine; alternateBy similarity1
Modified residuei65Omega-N-methylarginineBy similarity1
Modified residuei76Asymmetric dimethylarginineBy similarity1
Modified residuei83Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei83Omega-N-methylarginine; alternateBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei903PhosphoserineCombined sources1
Modified residuei990PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15735

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15735

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15735

PeptideAtlas

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PeptideAtlasi
Q15735

PRoteomics IDEntifications database

More...
PRIDEi
Q15735

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60724
60725 [Q15735-2]
60726 [Q15735-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q15735

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15735

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15735

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185133 Expressed in 134 organ(s), highest expression level in right lobe of thyroid gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_INPP5J

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15735 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15735 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034539

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118015, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q15735, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384534

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15735

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15735

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni425 – 728CatalyticSequence analysisAdd BLAST304
Regioni729 – 840Required for ruffle localizationBy similarityAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi102 – 107RSXSXX motif 16
Motifi345 – 350SH3-bindingSequence analysis6
Motifi350 – 355RSXSXX motif 26
Motifi874 – 879RSXSXX motif 36
Motifi885 – 890RSXSXX motif 46
Motifi911 – 916RSXSXX motif 56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi122 – 371Pro-richAdd BLAST250
Compositional biasi840 – 937Ser-richAdd BLAST98

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0565 Eukaryota
COG5411 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156855

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000046051

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG082135

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15735

KEGG Orthology (KO)

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KOi
K01106

Identification of Orthologs from Complete Genome Data

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OMAi
WITVVTW

Database of Orthologous Groups

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OrthoDBi
EOG091G055L

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15735

TreeFam database of animal gene trees

More...
TreeFami
TF317034

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03372 Exo_endo_phos, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00128 IPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219 SSF56219, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15735-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGQSSRGSR RPGTRAGLGS LPMPQGVAQT GAPSKVDSSF QLPAKKNAAL
60 70 80 90 100
GPSEPRLALA PVGPRAAMSA SSEGPRLALA SPRPILAPLC TPEGQKTATA
110 120 130 140 150
HRSSSLAPTS VGQLVMSASA GPKPPPATTG SVLAPTSLGL VMPASAGPRS
160 170 180 190 200
PPVTLGPNLA PTSRDQKQEP PASVGPKPTL AASGLSLALA SEEQPPELPS
210 220 230 240 250
TPSPVPSPVL SPTQEQALAP ASTASGAASV GQTSARKRDA PAPRPLPASE
260 270 280 290 300
GHLQPPAQTS GPTGSPPCIQ TSPDPRLSPS FRARPEALHS SPEDPVLPRP
310 320 330 340 350
PQTLPLDVGQ GPSEPGTHSP GLLSPTFRPG APSGQTVPPP LPKPPRSPSR
360 370 380 390 400
SPSHSPNRSP CVPPAPDMAL PRLGTQSTGP GRCLSPNLQA QEAPAPVTTS
410 420 430 440 450
SSTSTLSSSP WSAQPTWKSD PGFRITVVTW NVGTAMPPDD VTSLLHLGGG
460 470 480 490 500
DDSDGADMIA IGLQEVNSML NKRLKDALFT DQWSELFMDA LGPFNFVLVS
510 520 530 540 550
SVRMQGVILL LFAKYYHLPF LRDVQTDCTR TGLGGYWGNK GGVSVRLAAF
560 570 580 590 600
GHMLCFLNCH LPAHMDKAEQ RKDNFQTILS LQQFQGPGAQ GILDHDLVFW
610 620 630 640 650
FGDLNFRIES YDLHFVKFAI DSDQLHQLWE KDQLNMAKNT WPILKGFQEG
660 670 680 690 700
PLNFAPTFKF DVGTNKYDTS AKKRKPAWTD RILWKVKAPG GGPSPSGRKS
710 720 730 740 750
HRLQVTQHSY RSHMEYTVSD HKPVAAQFLL QFAFRDDMPL VRLEVADEWV
760 770 780 790 800
RPEQAVVRYR METVFARSSW DWIGLYRVGF RHCKDYVAYV WAKHEDVDGN
810 820 830 840 850
TYQVTFSEES LPKGHGDFIL GYYSHNHSIL IGITEPFQIS LPSSELASSS
860 870 880 890 900
TDSSGTSSEG EDDSTLELLA PKSRSPSPGK SKRHRSRSPG LARFPGLALR
910 920 930 940 950
PSSRERRGAS RSPSPQSRRL SRVAPDRSSN GSSRGSSEEG PSGLPGPWAF
960 970 980 990 1000
PPAVPRSLGL LPALRLETVD PGGGGSWGPD REALAPNSLS PSPQGHRGLE

EGGLGP
Length:1,006
Mass (Da):107,197
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADB6382AA33E15AC
GO
Isoform 2 (identifier: Q15735-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-367: Missing.

Show »
Length:639
Mass (Da):70,464
Checksum:i3ED5CD8BBB3398D0
GO
Isoform 3 (identifier: Q15735-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-423: Missing.

Note: No experimental confirmation available.
Show »
Length:638
Mass (Da):70,239
Checksum:i3F8ECF77ECC71C26
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DF95B4DF95_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
939Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVS7A0A087WVS7_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
571Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MBZ3B5MBZ3_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
371Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCL8B5MCL8_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
345Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0H5C9J0H5_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0M5C9K0M5_HUMAN
Phosphatidylinositol 4,5-bisphospha...
INPP5J
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD15618 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti610 – 612SYD → ARG (Ref. 5) Curated3
Sequence conflicti662V → A in BAC86611 (PubMed:14702039).Curated1
Sequence conflicti791W → R in AAI09289 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028107333S → I. Corresponds to variant dbSNP:rs12485025Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0072961 – 367Missing in isoform 2. 2 PublicationsAdd BLAST367
Alternative sequenceiVSP_02101756 – 423Missing in isoform 3. 1 PublicationAdd BLAST368

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK092859 mRNA Translation: BAG52616.1
AK095944 mRNA Translation: BAC04657.1
AK126610 mRNA Translation: BAC86611.1
AC005005 Genomic DNA Translation: AAD15618.1 Sequence problems.
CH471095 Genomic DNA Translation: EAW59936.1
BC109288 mRNA Translation: AAI09289.1
U45975 mRNA Translation: AAB03216.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46687.1 [Q15735-3]
CCDS63453.1 [Q15735-1]
CCDS63455.1 [Q15735-2]

NCBI Reference Sequences

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RefSeqi
NP_001002837.1, NM_001002837.2 [Q15735-3]
NP_001271214.1, NM_001284285.1 [Q15735-1]
NP_001271217.1, NM_001284288.1 [Q15735-2]
NP_001271218.1, NM_001284289.1 [Q15735-2]
XP_016884260.1, XM_017028771.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.517549

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000331075; ENSP00000333262; ENSG00000185133 [Q15735-1]
ENST00000400294; ENSP00000383150; ENSG00000185133 [Q15735-2]
ENST00000404390; ENSP00000384534; ENSG00000185133 [Q15735-3]
ENST00000405300; ENSP00000384596; ENSG00000185133 [Q15735-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27124

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27124

UCSC genome browser

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UCSCi
uc003ajs.5 human [Q15735-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092859 mRNA Translation: BAG52616.1
AK095944 mRNA Translation: BAC04657.1
AK126610 mRNA Translation: BAC86611.1
AC005005 Genomic DNA Translation: AAD15618.1 Sequence problems.
CH471095 Genomic DNA Translation: EAW59936.1
BC109288 mRNA Translation: AAI09289.1
U45975 mRNA Translation: AAB03216.1
CCDSiCCDS46687.1 [Q15735-3]
CCDS63453.1 [Q15735-1]
CCDS63455.1 [Q15735-2]
RefSeqiNP_001002837.1, NM_001002837.2 [Q15735-3]
NP_001271214.1, NM_001284285.1 [Q15735-1]
NP_001271217.1, NM_001284288.1 [Q15735-2]
NP_001271218.1, NM_001284289.1 [Q15735-2]
XP_016884260.1, XM_017028771.1
UniGeneiHs.517549

3D structure databases

ProteinModelPortaliQ15735
SMRiQ15735
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118015, 6 interactors
IntActiQ15735, 19 interactors
STRINGi9606.ENSP00000384534

PTM databases

DEPODiQ15735
iPTMnetiQ15735
PhosphoSitePlusiQ15735

Polymorphism and mutation databases

DMDMi116242713

Proteomic databases

EPDiQ15735
MaxQBiQ15735
PaxDbiQ15735
PeptideAtlasiQ15735
PRIDEiQ15735
ProteomicsDBi60724
60725 [Q15735-2]
60726 [Q15735-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331075; ENSP00000333262; ENSG00000185133 [Q15735-1]
ENST00000400294; ENSP00000383150; ENSG00000185133 [Q15735-2]
ENST00000404390; ENSP00000384534; ENSG00000185133 [Q15735-3]
ENST00000405300; ENSP00000384596; ENSG00000185133 [Q15735-2]
GeneIDi27124
KEGGihsa:27124
UCSCiuc003ajs.5 human [Q15735-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27124
DisGeNETi27124
EuPathDBiHostDB:ENSG00000185133.13

GeneCards: human genes, protein and diseases

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GeneCardsi
INPP5J
HGNCiHGNC:8956 INPP5J
HPAiHPA034539
MIMi606481 gene
neXtProtiNX_Q15735
OpenTargetsiENSG00000185133
PharmGKBiPA164720918

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
GeneTreeiENSGT00940000156855
HOGENOMiHOG000046051
HOVERGENiHBG082135
InParanoidiQ15735
KOiK01106
OMAiWITVVTW
OrthoDBiEOG091G055L
PhylomeDBiQ15735
TreeFamiTF317034

Enzyme and pathway databases

BioCyciMetaCyc:HS11950-MONOMER
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PIB5PA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27124

Protein Ontology

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PROi
PR:Q15735

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185133 Expressed in 134 organ(s), highest expression level in right lobe of thyroid gland
CleanExiHS_INPP5J
ExpressionAtlasiQ15735 baseline and differential
GenevisibleiQ15735 HS

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI5PA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15735
Secondary accession number(s): B3KS54
, Q32M61, Q6ZTH6, Q8N902, Q9UDT9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 17, 2006
Last modified: December 5, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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