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Protein

ETS-related transcription factor Elf-2

Gene

ELF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.
Isoform 2 may function in repression of RUNX1-mediated transactivation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi208 – 290ETSPROSITE-ProRule annotationAdd BLAST83

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
SignaLinkiQ15723
SIGNORiQ15723

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-2
Alternative name(s):
E74-like factor 2
New ETS-related factor
Gene namesi
Name:ELF2Imported
Synonyms:NERF1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109381.19
HGNCiHGNC:3317 ELF2
neXtProtiNX_Q15723

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1998
OpenTargetsiENSG00000109381
PharmGKBiPA27745

Polymorphism and mutation databases

DMDMi68052029

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040871 – 593ETS-related transcription factor Elf-2Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107PhosphoserineCombined sources1
Modified residuei182PhosphothreonineBy similarity1
Modified residuei185PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei376PhosphothreonineBy similarity1
Modified residuei430PhosphoserineCombined sources1
Modified residuei494Omega-N-methylarginineCombined sources1
Modified residuei521PhosphothreonineCombined sources1
Cross-linki536Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15723
PaxDbiQ15723
PeptideAtlasiQ15723
PRIDEiQ15723
ProteomicsDBi60718
60719 [Q15723-1]
60720 [Q15723-2]
60721 [Q15723-3]
60722 [Q15723-4]

PTM databases

iPTMnetiQ15723
PhosphoSitePlusiQ15723

Expressioni

Tissue specificityi

Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung, skeletal muscle, spleen, thymus, testis and ovary. Moderate expression in prostate, small intestine, kidney, liver and pancreas, and weak expression in colon, brain and peripheral blood lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000109381 Expressed in 219 organ(s), highest expression level in stomach
CleanExiHS_ELF2
ExpressionAtlasiQ15723 baseline and differential
GenevisibleiQ15723 HS

Organism-specific databases

HPAiHPA006057
HPA071166

Interactioni

Subunit structurei

Interacts with the LIM domains of LMO2 (By similarity). Interacts via its N-terminal region with RUNX1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RUNX1Q011962EBI-956941,EBI-925904

Protein-protein interaction databases

BioGridi108313, 18 interactors
IntActiQ15723, 10 interactors
MINTiQ15723
STRINGi9606.ENSP00000265495

Structurei

3D structure databases

ProteinModelPortaliQ15723
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000049253
HOVERGENiHBG007183
InParanoidiQ15723
KOiK09428
OMAiGSNVHCT
OrthoDBiEOG091G04CD
PhylomeDBiQ15723
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 51 Publication (identifier: Q15723-5) [UniParc]FASTAAdd to basket
Also known as: NERF-2b1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSAVVDSGG TILELSSNGV ENQEESEKVS EYPAVIVEPV PSARLEQGYA
60 70 80 90 100
AQVLVYDDET YMMQDVAEEQ EVETENVETV EASVHSSNAH CTDKTIEAAE
110 120 130 140 150
ALLHMESPTC LRDSRSPVEV FVPPCVSTPE FIHAAMRPDV ITETVVEVST
160 170 180 190 200
EESEPMDTSP IPTSPDSHEP MKKKKVGRKP KTQQSPISNG SPELGIKKKP
210 220 230 240 250
REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL VDSKAVSKLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID
310 320 330 340 350
DDKSETCNED LAGTTDEKSL ERVSLSAESL LKAASSVRSG KNSSPINCSR
360 370 380 390 400
AEKGVARVVN ITSPGHDASS RSPTTTASVS ATAAPRTVRV AMQVPVVMTS
410 420 430 440 450
LGQKISTVAV QSVNAGAPLI TSTSPTTATS PKVVIQTIPT VMPASTENGD
460 470 480 490 500
KITMQPAKII TIPATQLAQC QLQTKSNLTG SGSINIVGTP LAVRALTPVS
510 520 530 540 550
IAHGTPVMRL SMPTQQASGQ TPPRVISAVI KGPEVKSEAV AKKQEHDVKT
560 570 580 590
LQLVEEKPAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK
Length:593
Mass (Da):63,967
Last modified:June 21, 2005 - v2
Checksum:iB67013B453559910
GO
Isoform 11 Publication (identifier: Q15723-1) [UniParc]FASTAAdd to basket
Also known as: NERF-21 Publication, NERF-2a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     117-129: PVEVFVPPCVSTP → P

Show »
Length:581
Mass (Da):62,711
Checksum:i5D5E3169FF486A90
GO
Isoform 21 Publication (identifier: Q15723-2) [UniParc]FASTAAdd to basket
Also known as: NERF-1a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MTSAVVDSGG...QEVETENVET → MATSLHEGPTNQLDLLIRA
     117-129: PVEVFVPPCVSTP → P

Show »
Length:521
Mass (Da):56,133
Checksum:iA54F8DAA008C164D
GO
Isoform 31 Publication (identifier: Q15723-3) [UniParc]FASTAAdd to basket
Also known as: NERF-1b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MTSAVVDSGG...QEVETENVET → MATSLHEGPTNQLDLLIRA

Show »
Length:533
Mass (Da):57,389
Checksum:iDA45A5D12ECFD7E6
GO
Isoform 4Curated (identifier: Q15723-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MTSAVVDSGG...QEVETENVET → MATSLHEGPTNQLDLLIRA
     175-203: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:504
Mass (Da):54,261
Checksum:i0C6A1D98E54342CE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9B1D6R9B1_HUMAN
ETS-related transcription factor El...
ELF2
245Annotation score:
D6RHI1D6RHI1_HUMAN
ETS-related transcription factor El...
ELF2
192Annotation score:
D6RGD9D6RGD9_HUMAN
ETS-related transcription factor El...
ELF2
93Annotation score:

Sequence cautioni

The sequence AAH65025 differs from that shown. Reason: Frameshift at position 541.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0141541 – 79MTSAV…ENVET → MATSLHEGPTNQLDLLIRA in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST79
Alternative sequenceiVSP_014155117 – 129PVEVF…CVSTP → P in isoform 1 and isoform 2. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_014156175 – 203Missing in isoform 4. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43188 mRNA Translation: AAB37759.1
U43189 mRNA Translation: AAB37760.1
U43189 mRNA Translation: AAB37761.1
AF256222 mRNA Translation: AAF67195.1
AF256223 mRNA Translation: AAF67196.1
AC024032 Genomic DNA No translation available.
AC093602 Genomic DNA No translation available.
BC034951 mRNA Translation: AAH34951.1
BC065025 mRNA Translation: AAH65025.1 Frameshift.
CCDSiCCDS3744.1 [Q15723-1]
CCDS3745.1 [Q15723-3]
CCDS64062.1 [Q15723-2]
CCDS64063.1 [Q15723-4]
CCDS82954.1 [Q15723-5]
PIRiG02318
RefSeqiNP_001263386.1, NM_001276457.1 [Q15723-4]
NP_001263387.1, NM_001276458.1 [Q15723-2]
NP_001263388.1, NM_001276459.1
NP_001317965.1, NM_001331036.1 [Q15723-5]
NP_006865.1, NM_006874.3 [Q15723-3]
NP_973728.1, NM_201999.2 [Q15723-1]
XP_005262861.1, XM_005262804.2 [Q15723-1]
UniGeneiHs.634040

Genome annotation databases

EnsembliENST00000358635; ENSP00000351458; ENSG00000109381 [Q15723-3]
ENST00000379549; ENSP00000368867; ENSG00000109381 [Q15723-4]
ENST00000379550; ENSP00000368868; ENSG00000109381 [Q15723-5]
ENST00000394235; ENSP00000377782; ENSG00000109381 [Q15723-1]
ENST00000510408; ENSP00000426997; ENSG00000109381 [Q15723-2]
GeneIDi1998
KEGGihsa:1998
UCSCiuc003ihm.3 human [Q15723-5]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43188 mRNA Translation: AAB37759.1
U43189 mRNA Translation: AAB37760.1
U43189 mRNA Translation: AAB37761.1
AF256222 mRNA Translation: AAF67195.1
AF256223 mRNA Translation: AAF67196.1
AC024032 Genomic DNA No translation available.
AC093602 Genomic DNA No translation available.
BC034951 mRNA Translation: AAH34951.1
BC065025 mRNA Translation: AAH65025.1 Frameshift.
CCDSiCCDS3744.1 [Q15723-1]
CCDS3745.1 [Q15723-3]
CCDS64062.1 [Q15723-2]
CCDS64063.1 [Q15723-4]
CCDS82954.1 [Q15723-5]
PIRiG02318
RefSeqiNP_001263386.1, NM_001276457.1 [Q15723-4]
NP_001263387.1, NM_001276458.1 [Q15723-2]
NP_001263388.1, NM_001276459.1
NP_001317965.1, NM_001331036.1 [Q15723-5]
NP_006865.1, NM_006874.3 [Q15723-3]
NP_973728.1, NM_201999.2 [Q15723-1]
XP_005262861.1, XM_005262804.2 [Q15723-1]
UniGeneiHs.634040

3D structure databases

ProteinModelPortaliQ15723
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108313, 18 interactors
IntActiQ15723, 10 interactors
MINTiQ15723
STRINGi9606.ENSP00000265495

PTM databases

iPTMnetiQ15723
PhosphoSitePlusiQ15723

Polymorphism and mutation databases

DMDMi68052029

Proteomic databases

EPDiQ15723
PaxDbiQ15723
PeptideAtlasiQ15723
PRIDEiQ15723
ProteomicsDBi60718
60719 [Q15723-1]
60720 [Q15723-2]
60721 [Q15723-3]
60722 [Q15723-4]

Protocols and materials databases

DNASUi1998
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358635; ENSP00000351458; ENSG00000109381 [Q15723-3]
ENST00000379549; ENSP00000368867; ENSG00000109381 [Q15723-4]
ENST00000379550; ENSP00000368868; ENSG00000109381 [Q15723-5]
ENST00000394235; ENSP00000377782; ENSG00000109381 [Q15723-1]
ENST00000510408; ENSP00000426997; ENSG00000109381 [Q15723-2]
GeneIDi1998
KEGGihsa:1998
UCSCiuc003ihm.3 human [Q15723-5]

Organism-specific databases

CTDi1998
DisGeNETi1998
EuPathDBiHostDB:ENSG00000109381.19
GeneCardsiELF2
H-InvDBiHIX0164010
HGNCiHGNC:3317 ELF2
HPAiHPA006057
HPA071166
neXtProtiNX_Q15723
OpenTargetsiENSG00000109381
PharmGKBiPA27745
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000049253
HOVERGENiHBG007183
InParanoidiQ15723
KOiK09428
OMAiGSNVHCT
OrthoDBiEOG091G04CD
PhylomeDBiQ15723
TreeFamiTF318679

Enzyme and pathway databases

ReactomeiR-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
SignaLinkiQ15723
SIGNORiQ15723

Miscellaneous databases

ChiTaRSiELF2 human
GeneWikiiELF2
GenomeRNAii1998
PROiPR:Q15723

Gene expression databases

BgeeiENSG00000109381 Expressed in 219 organ(s), highest expression level in stomach
CleanExiHS_ELF2
ExpressionAtlasiQ15723 baseline and differential
GenevisibleiQ15723 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELF2_HUMAN
AccessioniPrimary (citable) accession number: Q15723
Secondary accession number(s): E9PCX3
, Q15724, Q15725, Q6P1K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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