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Entry version 170 (08 May 2019)
Sequence version 2 (21 Jun 2005)
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Protein

ETS-related transcription factor Elf-2

Gene

ELF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.
Isoform 2 may function in repression of RUNX1-mediated transactivation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi208 – 290ETSPROSITE-ProRule annotationAdd BLAST83

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q15723

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q15723

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ETS-related transcription factor Elf-2
Alternative name(s):
E74-like factor 2
New ETS-related factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELF2Imported
Synonyms:NERF1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:3317 ELF2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15723

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1998

Open Targets

More...
OpenTargetsi
ENSG00000109381

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27745

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ELF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68052029

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002040871 – 593ETS-related transcription factor Elf-2Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei107PhosphoserineCombined sources1
Modified residuei182PhosphothreonineBy similarity1
Modified residuei185PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei376PhosphothreonineBy similarity1
Modified residuei430PhosphoserineCombined sources1
Modified residuei494Omega-N-methylarginineCombined sources1
Modified residuei521PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki536Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15723

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15723

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15723

PeptideAtlas

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PeptideAtlasi
Q15723

PRoteomics IDEntifications database

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PRIDEi
Q15723

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60718
60719 [Q15723-1]
60720 [Q15723-2]
60721 [Q15723-3]
60722 [Q15723-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15723

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15723

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung, skeletal muscle, spleen, thymus, testis and ovary. Moderate expression in prostate, small intestine, kidney, liver and pancreas, and weak expression in colon, brain and peripheral blood lymphocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109381 Expressed in 219 organ(s), highest expression level in stomach

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15723 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15723 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006057
HPA071166

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the LIM domains of LMO2 (By similarity). Interacts via its N-terminal region with RUNX1.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RUNX1Q011962EBI-956941,EBI-925904

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108313, 20 interactors

Protein interaction database and analysis system

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IntActi
Q15723, 10 interactors

Molecular INTeraction database

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MINTi
Q15723

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377782

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3804 Eukaryota
ENOG4111K4J LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154953

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049253

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15723

KEGG Orthology (KO)

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KOi
K09428

Identification of Orthologs from Complete Genome Data

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OMAi
GSNVHCT

Database of Orthologous Groups

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OrthoDBi
837296at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15723

TreeFam database of animal gene trees

More...
TreeFami
TF318679

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00454 ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00413 ETS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 51 Publication (identifier: Q15723-5) [UniParc]FASTAAdd to basket
Also known as: NERF-2b1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSAVVDSGG TILELSSNGV ENQEESEKVS EYPAVIVEPV PSARLEQGYA
60 70 80 90 100
AQVLVYDDET YMMQDVAEEQ EVETENVETV EASVHSSNAH CTDKTIEAAE
110 120 130 140 150
ALLHMESPTC LRDSRSPVEV FVPPCVSTPE FIHAAMRPDV ITETVVEVST
160 170 180 190 200
EESEPMDTSP IPTSPDSHEP MKKKKVGRKP KTQQSPISNG SPELGIKKKP
210 220 230 240 250
REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL VDSKAVSKLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID
310 320 330 340 350
DDKSETCNED LAGTTDEKSL ERVSLSAESL LKAASSVRSG KNSSPINCSR
360 370 380 390 400
AEKGVARVVN ITSPGHDASS RSPTTTASVS ATAAPRTVRV AMQVPVVMTS
410 420 430 440 450
LGQKISTVAV QSVNAGAPLI TSTSPTTATS PKVVIQTIPT VMPASTENGD
460 470 480 490 500
KITMQPAKII TIPATQLAQC QLQTKSNLTG SGSINIVGTP LAVRALTPVS
510 520 530 540 550
IAHGTPVMRL SMPTQQASGQ TPPRVISAVI KGPEVKSEAV AKKQEHDVKT
560 570 580 590
LQLVEEKPAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK
Length:593
Mass (Da):63,967
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB67013B453559910
GO
Isoform 11 Publication (identifier: Q15723-1) [UniParc]FASTAAdd to basket
Also known as: NERF-21 Publication, NERF-2a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     117-129: PVEVFVPPCVSTP → P

Show »
Length:581
Mass (Da):62,711
Checksum:i5D5E3169FF486A90
GO
Isoform 21 Publication (identifier: Q15723-2) [UniParc]FASTAAdd to basket
Also known as: NERF-1a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MTSAVVDSGG...QEVETENVET → MATSLHEGPTNQLDLLIRA
     117-129: PVEVFVPPCVSTP → P

Show »
Length:521
Mass (Da):56,133
Checksum:iA54F8DAA008C164D
GO
Isoform 31 Publication (identifier: Q15723-3) [UniParc]FASTAAdd to basket
Also known as: NERF-1b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MTSAVVDSGG...QEVETENVET → MATSLHEGPTNQLDLLIRA

Show »
Length:533
Mass (Da):57,389
Checksum:iDA45A5D12ECFD7E6
GO
Isoform 4Curated (identifier: Q15723-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MTSAVVDSGG...QEVETENVET → MATSLHEGPTNQLDLLIRA
     175-203: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:504
Mass (Da):54,261
Checksum:i0C6A1D98E54342CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9B1D6R9B1_HUMAN
ETS-related transcription factor El...
ELF2
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHI1D6RHI1_HUMAN
ETS-related transcription factor El...
ELF2
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGD9D6RGD9_HUMAN
ETS-related transcription factor El...
ELF2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH65025 differs from that shown. Reason: Frameshift at position 541.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0141541 – 79MTSAV…ENVET → MATSLHEGPTNQLDLLIRA in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST79
Alternative sequenceiVSP_014155117 – 129PVEVF…CVSTP → P in isoform 1 and isoform 2. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_014156175 – 203Missing in isoform 4. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U43188 mRNA Translation: AAB37759.1
U43189 mRNA Translation: AAB37760.1
U43189 mRNA Translation: AAB37761.1
AF256222 mRNA Translation: AAF67195.1
AF256223 mRNA Translation: AAF67196.1
AC024032 Genomic DNA No translation available.
AC093602 Genomic DNA No translation available.
BC034951 mRNA Translation: AAH34951.1
BC065025 mRNA Translation: AAH65025.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3744.1 [Q15723-1]
CCDS3745.1 [Q15723-3]
CCDS64062.1 [Q15723-2]
CCDS64063.1 [Q15723-4]
CCDS82954.1 [Q15723-5]

Protein sequence database of the Protein Information Resource

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PIRi
G02318

NCBI Reference Sequences

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RefSeqi
NP_001263386.1, NM_001276457.1 [Q15723-4]
NP_001263387.1, NM_001276458.1 [Q15723-2]
NP_001263388.1, NM_001276459.1
NP_001317965.1, NM_001331036.1 [Q15723-5]
NP_006865.1, NM_006874.3 [Q15723-3]
NP_973728.1, NM_201999.2 [Q15723-1]
XP_005262861.1, XM_005262804.2 [Q15723-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358635; ENSP00000351458; ENSG00000109381 [Q15723-3]
ENST00000379549; ENSP00000368867; ENSG00000109381 [Q15723-4]
ENST00000379550; ENSP00000368868; ENSG00000109381 [Q15723-5]
ENST00000394235; ENSP00000377782; ENSG00000109381 [Q15723-1]
ENST00000510408; ENSP00000426997; ENSG00000109381 [Q15723-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1998

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1998

UCSC genome browser

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UCSCi
uc003ihm.3 human [Q15723-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43188 mRNA Translation: AAB37759.1
U43189 mRNA Translation: AAB37760.1
U43189 mRNA Translation: AAB37761.1
AF256222 mRNA Translation: AAF67195.1
AF256223 mRNA Translation: AAF67196.1
AC024032 Genomic DNA No translation available.
AC093602 Genomic DNA No translation available.
BC034951 mRNA Translation: AAH34951.1
BC065025 mRNA Translation: AAH65025.1 Frameshift.
CCDSiCCDS3744.1 [Q15723-1]
CCDS3745.1 [Q15723-3]
CCDS64062.1 [Q15723-2]
CCDS64063.1 [Q15723-4]
CCDS82954.1 [Q15723-5]
PIRiG02318
RefSeqiNP_001263386.1, NM_001276457.1 [Q15723-4]
NP_001263387.1, NM_001276458.1 [Q15723-2]
NP_001263388.1, NM_001276459.1
NP_001317965.1, NM_001331036.1 [Q15723-5]
NP_006865.1, NM_006874.3 [Q15723-3]
NP_973728.1, NM_201999.2 [Q15723-1]
XP_005262861.1, XM_005262804.2 [Q15723-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi108313, 20 interactors
IntActiQ15723, 10 interactors
MINTiQ15723
STRINGi9606.ENSP00000377782

PTM databases

iPTMnetiQ15723
PhosphoSitePlusiQ15723

Polymorphism and mutation databases

BioMutaiELF2
DMDMi68052029

Proteomic databases

EPDiQ15723
jPOSTiQ15723
PaxDbiQ15723
PeptideAtlasiQ15723
PRIDEiQ15723
ProteomicsDBi60718
60719 [Q15723-1]
60720 [Q15723-2]
60721 [Q15723-3]
60722 [Q15723-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1998
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358635; ENSP00000351458; ENSG00000109381 [Q15723-3]
ENST00000379549; ENSP00000368867; ENSG00000109381 [Q15723-4]
ENST00000379550; ENSP00000368868; ENSG00000109381 [Q15723-5]
ENST00000394235; ENSP00000377782; ENSG00000109381 [Q15723-1]
ENST00000510408; ENSP00000426997; ENSG00000109381 [Q15723-2]
GeneIDi1998
KEGGihsa:1998
UCSCiuc003ihm.3 human [Q15723-5]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1998
DisGeNETi1998

GeneCards: human genes, protein and diseases

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GeneCardsi
ELF2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0164010
HGNCiHGNC:3317 ELF2
HPAiHPA006057
HPA071166
neXtProtiNX_Q15723
OpenTargetsiENSG00000109381
PharmGKBiPA27745

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00940000154953
HOGENOMiHOG000049253
InParanoidiQ15723
KOiK09428
OMAiGSNVHCT
OrthoDBi837296at2759
PhylomeDBiQ15723
TreeFamiTF318679

Enzyme and pathway databases

ReactomeiR-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
SignaLinkiQ15723
SIGNORiQ15723

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ELF2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ELF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1998

Protein Ontology

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PROi
PR:Q15723

Gene expression databases

BgeeiENSG00000109381 Expressed in 219 organ(s), highest expression level in stomach
ExpressionAtlasiQ15723 baseline and differential
GenevisibleiQ15723 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15723
Secondary accession number(s): E9PCX3
, Q15724, Q15725, Q6P1K5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: May 8, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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