UniProtKB - Q15722 (LT4R1_HUMAN)
Protein
Leukotriene B4 receptor 1
Gene
LTB4R
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
GO - Molecular functioni
- galanin receptor activity Source: GO_Central
- G protein-coupled peptide receptor activity Source: GO_Central
- leukotriene B4 receptor activity Source: GO_Central
- leukotriene receptor activity Source: ProtInc
- nucleotide binding Source: ProtInc
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Reactome
- immune response Source: ProtInc
- inflammatory response Source: GO_Central
- muscle contraction Source: ProtInc
- neuropeptide signaling pathway Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-391906 Leukotriene receptors R-HSA-416476 G alpha (q) signalling events |
SIGNORi | Q15722 |
Protein family/group databases
TCDBi | 9.A.14.13.5 the g-protein-coupled receptor (gpcr) family |
Chemistry databases
SwissLipidsi | SLP:000001555 |
Names & Taxonomyi
Protein namesi | Recommended name: Leukotriene B4 receptor 1Short name: LTB4-R 1 Short name: LTB4-R1 Alternative name(s): Chemoattractant receptor-like 1 G-protein coupled receptor 16 P2Y purinoceptor 7 Short name: P2Y7 |
Gene namesi | Name:LTB4R Synonyms:BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6713 LTB4R |
MIMi | 601531 gene |
neXtProti | NX_Q15722 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- membrane raft Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 42 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 43 – 54 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 55 – 75 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 91 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 92 – 113 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 114 – 138 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 139 – 159 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 160 – 178 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 179 – 199 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 200 – 221 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 222 – 242 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 243 – 268 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 269 – 289 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 352 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 308 | T → P or A: No effect on affinity for leukotriene B4, induces resistance to desensitization by GRK6, but minor effect on phosphorylation by GRK6. 1 Publication | 1 | |
Mutagenesisi | 310 | S → A: No effect on affinity for leukotriene B4 or on desensitization by GRK6. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1241 |
OpenTargetsi | ENSG00000213903 |
PharmGKBi | PA30476 |
Miscellaneous databases
Pharosi | Q15722 |
Chemistry databases
ChEMBLi | CHEMBL3911 |
DrugBanki | DB06248 Amelubant DB12961 Leukotriene B4 DB09285 Morniflumate |
DrugCentrali | Q15722 |
GuidetoPHARMACOLOGYi | 267 |
Polymorphism and mutation databases
BioMutai | LTB4R |
DMDMi | 3041713 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069708 | 1 – 352 | Leukotriene B4 receptor 1Add BLAST | 352 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 164 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.1 Publication
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q15722 |
jPOSTi | Q15722 |
MassIVEi | Q15722 |
PaxDbi | Q15722 |
PeptideAtlasi | Q15722 |
PRIDEi | Q15722 |
ProteomicsDBi | 60717 |
PTM databases
iPTMneti | Q15722 |
PhosphoSitePlusi | Q15722 |
Expressioni
Tissue specificityi
Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.
Gene expression databases
Bgeei | ENSG00000213903 Expressed in 152 organ(s), highest expression level in ectocervix |
ExpressionAtlasi | Q15722 baseline and differential |
Genevisiblei | Q15722 HS |
Organism-specific databases
HPAi | HPA003873 |
Interactioni
Protein-protein interaction databases
BioGridi | 107645, 9 interactors |
IntActi | Q15722, 1 interactor |
STRINGi | 9606.ENSP00000380008 |
Chemistry databases
BindingDBi | Q15722 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00950000182966 |
HOGENOMi | HOG000008594 |
InParanoidi | Q15722 |
KOi | K04296 |
OMAi | YICGVSM |
OrthoDBi | 978296at2759 |
PhylomeDBi | Q15722 |
TreeFami | TF330976 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR003981 Leukotriene_B4_rcpt IPR003983 Leukotriene_B4_typ-1_rcpt |
PANTHERi | PTHR24230:SF51 PTHR24230:SF51, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01477 LTB1RECEPTOR PR01476 LTBRECEPTOR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q15722-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR
60 70 80 90 100
SVTALMVLNL ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS
110 120 130 140 150
MYASVLLITA MSLDRSLAVA RPFVSQKLRT KAMARRVLAG IWVLSFLLAT
160 170 180 190 200
PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF HLIFEAVTGF LLPFLAVVAS
210 220 230 240 250
YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV NLAEAGRALA
260 270 280 290 300
GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
310 320 330 340 350
VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE
LN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V4Q5 | G3V4Q5_HUMAN | Leukotriene B4 receptor 1 | LTB4R | 232 | Annotation score: | ||
G3V244 | G3V244_HUMAN | Leukotriene B4 receptor 1 | LTB4R | 102 | Annotation score: |
Sequence cautioni
The sequence AAB16747 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 246 | G → R in CAA67001 (PubMed:8921391).Curated | 1 | |
Sequence conflicti | 272 | A → V in AAC50628 (PubMed:8702478).Curated | 1 | |
Sequence conflicti | 293 | L → V in AAC50628 (PubMed:8702478).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060679 | 346 | L → F2 PublicationsCorresponds to variant dbSNP:rs17849864Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U41070 mRNA Translation: AAC50628.1 U33448 Genomic DNA Translation: AAB16747.1 Different initiation. D89079 mRNA Translation: BAA20424.1 D89078 mRNA Translation: BAA20423.1 X98356 mRNA Translation: CAA67001.1 AB008193 Genomic DNA Translation: BAB00611.1 AY322535 Genomic DNA Translation: AAP84348.1 BT007267 mRNA Translation: AAP35931.1 BC004545 mRNA Translation: AAH04545.1 |
CCDSi | CCDS9626.1 |
RefSeqi | NP_001137391.1, NM_001143919.2 NP_858043.1, NM_181657.3 |
Genome annotation databases
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U41070 mRNA Translation: AAC50628.1 U33448 Genomic DNA Translation: AAB16747.1 Different initiation. D89079 mRNA Translation: BAA20424.1 D89078 mRNA Translation: BAA20423.1 X98356 mRNA Translation: CAA67001.1 AB008193 Genomic DNA Translation: BAB00611.1 AY322535 Genomic DNA Translation: AAP84348.1 BT007267 mRNA Translation: AAP35931.1 BC004545 mRNA Translation: AAH04545.1 |
CCDSi | CCDS9626.1 |
RefSeqi | NP_001137391.1, NM_001143919.2 NP_858043.1, NM_181657.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 107645, 9 interactors |
IntActi | Q15722, 1 interactor |
STRINGi | 9606.ENSP00000380008 |
Chemistry databases
BindingDBi | Q15722 |
ChEMBLi | CHEMBL3911 |
DrugBanki | DB06248 Amelubant DB12961 Leukotriene B4 DB09285 Morniflumate |
DrugCentrali | Q15722 |
GuidetoPHARMACOLOGYi | 267 |
SwissLipidsi | SLP:000001555 |
Protein family/group databases
TCDBi | 9.A.14.13.5 the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
iPTMneti | Q15722 |
PhosphoSitePlusi | Q15722 |
Polymorphism and mutation databases
BioMutai | LTB4R |
DMDMi | 3041713 |
Proteomic databases
EPDi | Q15722 |
jPOSTi | Q15722 |
MassIVEi | Q15722 |
PaxDbi | Q15722 |
PeptideAtlasi | Q15722 |
PRIDEi | Q15722 |
ProteomicsDBi | 60717 |
Protocols and materials databases
DNASUi | 1241 |
Genome annotation databases
Organism-specific databases
CTDi | 1241 |
DisGeNETi | 1241 |
GeneCardsi | LTB4R |
HGNCi | HGNC:6713 LTB4R |
HPAi | HPA003873 |
MIMi | 601531 gene |
neXtProti | NX_Q15722 |
OpenTargetsi | ENSG00000213903 |
PharmGKBi | PA30476 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00950000182966 |
HOGENOMi | HOG000008594 |
InParanoidi | Q15722 |
KOi | K04296 |
OMAi | YICGVSM |
OrthoDBi | 978296at2759 |
PhylomeDBi | Q15722 |
TreeFami | TF330976 |
Enzyme and pathway databases
Reactomei | R-HSA-391906 Leukotriene receptors R-HSA-416476 G alpha (q) signalling events |
SIGNORi | Q15722 |
Miscellaneous databases
ChiTaRSi | LTB4R human |
GeneWikii | Leukotriene_B4_receptor |
GenomeRNAii | 1241 |
Pharosi | Q15722 |
PROi | PR:Q15722 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213903 Expressed in 152 organ(s), highest expression level in ectocervix |
ExpressionAtlasi | Q15722 baseline and differential |
Genevisiblei | Q15722 HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR003981 Leukotriene_B4_rcpt IPR003983 Leukotriene_B4_typ-1_rcpt |
PANTHERi | PTHR24230:SF51 PTHR24230:SF51, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01477 LTB1RECEPTOR PR01476 LTBRECEPTOR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LT4R1_HUMAN | |
Accessioni | Q15722Primary (citable) accession number: Q15722 Secondary accession number(s): Q13305 Q9BSU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 15, 1998 | |
Last modified: | October 16, 2019 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot