UniProtKB - Q15714 (T22D1_HUMAN)
Protein
TSC22 domain family protein 1
Gene
TSC22D1
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: InterPro
- transcription by RNA polymerase II Source: ProtInc
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q15714 |
Names & Taxonomyi
Protein namesi | Recommended name: TSC22 domain family protein 1Alternative name(s): Cerebral protein 2 Regulatory protein TSC-22 TGFB-stimulated clone 22 homolog Transforming growth factor beta-1-induced transcript 4 protein |
Gene namesi | Name:TSC22D1 Synonyms:KIAA1994, TGFB1I4, TSC22 ORF Names:hucep-2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16826, TSC22D1 |
MIMi | 607715, gene |
neXtProti | NX_Q15714 |
VEuPathDBi | HostDB:ENSG00000102804.14 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 8848 |
OpenTargetsi | ENSG00000102804 |
PharmGKBi | PA134887618 |
Miscellaneous databases
Pharosi | Q15714, Tbio |
Genetic variation databases
BioMutai | TSC22D1 |
DMDMi | 334302874 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219365 | 1 – 1073 | TSC22 domain family protein 1Add BLAST | 1073 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 263 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15714 |
jPOSTi | Q15714 |
MassIVEi | Q15714 |
MaxQBi | Q15714 |
PaxDbi | Q15714 |
PeptideAtlasi | Q15714 |
PRIDEi | Q15714 |
ProteomicsDBi | 3607 60713 [Q15714-1] 60714 [Q15714-2] 60715 [Q15714-3] |
TopDownProteomicsi | Q15714-3 [Q15714-3] |
PTM databases
iPTMneti | Q15714 |
MetOSitei | Q15714 |
PhosphoSitePlusi | Q15714 |
Expressioni
Tissue specificityi
Widely expressed in fetal and adult tissues.
Inductioni
In aortic endothelial cells, induced by cytokines, including TGFB1.
Gene expression databases
Bgeei | ENSG00000102804, Expressed in endothelial cell and 248 other tissues |
ExpressionAtlasi | Q15714, baseline and differential |
Genevisiblei | Q15714, HS |
Organism-specific databases
HPAi | ENSG00000102804, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer or heterodimer. Can form a heterodimer with TSC22D4.
Binary interactionsi
Hide detailsQ15714
With | #Exp. | IntAct |
---|---|---|
NTAQ1 [Q96HA8] | 4 | EBI-712609,EBI-741158 |
TPT1 [P13693] | 5 | EBI-712609,EBI-1783169 |
Isoform 2 [Q15714-2]
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-12034704,EBI-77613 |
GORASP2 [Q9H8Y8] | 8 | EBI-12034704,EBI-739467 |
NTAQ1 [Q96HA8] | 3 | EBI-12034704,EBI-741158 |
Protein-protein interaction databases
BioGRIDi | 114374, 96 interactors |
IntActi | Q15714, 53 interactors |
MINTi | Q15714 |
STRINGi | 9606.ENSP00000397435 |
Miscellaneous databases
RNActi | Q15714, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1006 – 1027 | Leucine-zipperAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 59 – 82 | Pro-richAdd BLAST | 24 | |
Compositional biasi | 195 – 241 | His-richAdd BLAST | 47 | |
Compositional biasi | 497 – 817 | Gln-richAdd BLAST | 321 |
Sequence similaritiesi
Belongs to the TSC-22/Dip/Bun family.Curated
Phylogenomic databases
eggNOGi | KOG4797, Eukaryota |
GeneTreei | ENSGT00940000159144 |
HOGENOMi | CLU_148757_0_0_1 |
InParanoidi | Q15714 |
OMAi | SIVNPQT |
OrthoDBi | 1602203at2759 |
PhylomeDBi | Q15714 |
TreeFami | TF318837 |
Family and domain databases
InterProi | View protein in InterPro IPR000580, TSC-22_Dip_Bun |
Pfami | View protein in Pfam PF01166, TSC22, 1 hit |
PROSITEi | View protein in PROSITE PS01289, TSC22, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q15714-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHQPPESTAA AAAAADISAR KMAHPAMFPR RGSGSGSASA LNAAGTGVGS
60 70 80 90 100
NATSSEDFPP PSLLQPPPPA ASSTSGPQPP PPQSLNLLSQ AQLQAQPLAP
110 120 130 140 150
GGTQMKKKSG FQITSVTPAQ ISASISSNNS IAEDTESYDD LDESHTEDLS
160 170 180 190 200
SSEILDVSLS RATDLGEPER SSSEETLNNF QEAETPGAVS PNQPHLPQPH
210 220 230 240 250
LPHLPQQNVV INGNAHPHHL HHHHQIHHGH HLQHGHHHPS HVAVASASIT
260 270 280 290 300
GGPPSSPVSR KLSTTGSSDS ITPVAPTSAV SSSGSPASVM TNMRAPSTTG
310 320 330 340 350
GIGINSVTGT STVNNVNITA VGSFNPNVTS SMLGNVNIST SNIPSAAGVS
360 370 380 390 400
VGPGVTSGVN VNILSGMGNG TISSSAAVSS VPNAAAGMTG GSVSSQQQQP
410 420 430 440 450
TVNTSRFRVV KLDSSSEPFK KGRWTCTEFY EKENAVPATE GVLINKVVET
460 470 480 490 500
VKQNPIEVTS ERESTSGSSV SSSVSTLSHY TESVGSGEMG APTVVVQQQQ
510 520 530 540 550
QQQQQQQQQP ALQGVTLQQM DFGSTGPQSI PAVSIPQSIS QSQISQVQLQ
560 570 580 590 600
SQELSYQQKQ GLQPVPLQAT MSAATGIQPS PVNVVGVTSA LGQQPSISSL
610 620 630 640 650
AQPQLPYSQA APPVQTPLPG APPPQQLQYG QQQPMVSTQM APGHVKSVTQ
660 670 680 690 700
NPASEYVQQQ PILQTAMSSG QPSSAGVGAG TTVIPVAQPQ GIQLPVQPTA
710 720 730 740 750
VPAQPAGASV QPVGQAPAAV SAVPTGSQIA NIGQQANIPT AVQQPSTQVP
760 770 780 790 800
PSVIQQGAPP SSQVVPPAQT GIIHQGVQTS APSLPQQLVI ASQSSLLTVP
810 820 830 840 850
PQPQGVEPVA QGIVSQQLPA VSSLPSASSI SVTSQVSSTG PSGMPSAPTN
860 870 880 890 900
LVPPQNIAQT PATQNGNLVQ SVSQPPLIAT NTNLPLAQQI PLSSTQFSAQ
910 920 930 940 950
SLAQAIGSQI EDARRAAEPS LVGLPQTISG DSGGMSAVSD GSSSSLAASA
960 970 980 990 1000
SLFPLKVLPL TTPLVDGEDE SSSGASVVAI DNKIEQAMDL VKSHLMYAVR
1010 1020 1030 1040 1050
EEVEVLKEQI KELIEKNSQL EQENNLLKTL ASPEQLAQFQ AQLQTGSPPA
1060 1070
TTQPQGTTQP PAQPASQGSG PTA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X0H8 | A0A087X0H8_HUMAN | TSC22 domain family protein 1 | TSC22D1 | 86 | Annotation score: | ||
C9IZ15 | C9IZ15_HUMAN | TSC22 domain family protein 1 | TSC22D1 | 142 | Annotation score: | ||
H7C4J9 | H7C4J9_HUMAN | TSC22 domain family protein 1 | TSC22D1 | 149 | Annotation score: | ||
C9JYW3 | C9JYW3_HUMAN | TSC22 domain family protein 1 | TSC22D1 | 41 | Annotation score: |
Sequence cautioni
The sequence BAC02703 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 332 | M → I in BAC02703 (PubMed:12056414).Curated | 1 | ||
Sequence conflicti | 581 | P → L in CAH10539 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 661 | P → S in CAH10539 (PubMed:15489334).Curated | 1 | ||
Isoform 2 (identifier: Q15714-2) | |||||
Sequence conflicti | 15 | V → A in BAB46917 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057311 | 652 | P → S. Corresponds to variant dbSNP:rs9525983Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035325 | 1 – 921 | Missing in isoform 2. 7 PublicationsAdd BLAST | 921 | |
Alternative sequenceiVSP_035324 | 1 – 488 | Missing in isoform 3. 1 PublicationAdd BLAST | 488 | |
Alternative sequenceiVSP_044939 | 557 – 570 | QQKQG…PLQAT → LTMKVVLLIVYLCM in isoform 4. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_044940 | 571 – 1073 | Missing in isoform 4. 1 PublicationAdd BLAST | 503 | |
Alternative sequenceiVSP_035326 | 922 – 970 | VGLPQ…DGEDE → MKSQWCRPVAMDLGVYQLRH FSISFLSSLLGTENASVRLD N in isoform 2. 7 PublicationsAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U35048 mRNA Translation: AAC50566.1 D38585 mRNA Translation: BAA07598.1 AJ222700 mRNA Translation: CAA10951.1 D87061 mRNA Translation: BAB46917.1 AF256226 Genomic DNA Translation: AAG53077.1 AB082525 mRNA Translation: BAC02703.1 Different initiation. AK091854 mRNA Translation: BAG52429.1 AK312345 mRNA Translation: BAG35266.1 CR456711 mRNA Translation: CAG32992.1 CR627459 mRNA Translation: CAH10539.1 AL138960 Genomic DNA No translation available. AL139184 Genomic DNA No translation available. AL356107 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08710.1 BC000456 mRNA Translation: AAH00456.1 BC016867 mRNA Translation: AAH16867.1 BC069207 mRNA Translation: AAH69207.1 BC105277 mRNA Translation: AAI05278.1 BC136475 mRNA Translation: AAI36476.1 BC136482 mRNA Translation: AAI36483.1 BC146664 mRNA Translation: AAI46665.1 BC146679 mRNA Translation: AAI46680.1 |
CCDSi | CCDS31966.1 [Q15714-1] CCDS58291.1 [Q15714-4] CCDS9392.1 [Q15714-2] |
PIRi | JC4813 |
RefSeqi | NP_001230728.1, NM_001243799.1 [Q15714-4] NP_006013.1, NM_006022.3 [Q15714-2] NP_904358.2, NM_183422.3 [Q15714-1] |
Genome annotation databases
Ensembli | ENST00000261489; ENSP00000261489; ENSG00000102804 [Q15714-2] ENST00000458659; ENSP00000397435; ENSG00000102804 [Q15714-1] ENST00000501704; ENSP00000437414; ENSG00000102804 [Q15714-4] |
GeneIDi | 8848 |
KEGGi | hsa:8848 |
UCSCi | uc001uzm.5, human [Q15714-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U35048 mRNA Translation: AAC50566.1 D38585 mRNA Translation: BAA07598.1 AJ222700 mRNA Translation: CAA10951.1 D87061 mRNA Translation: BAB46917.1 AF256226 Genomic DNA Translation: AAG53077.1 AB082525 mRNA Translation: BAC02703.1 Different initiation. AK091854 mRNA Translation: BAG52429.1 AK312345 mRNA Translation: BAG35266.1 CR456711 mRNA Translation: CAG32992.1 CR627459 mRNA Translation: CAH10539.1 AL138960 Genomic DNA No translation available. AL139184 Genomic DNA No translation available. AL356107 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08710.1 BC000456 mRNA Translation: AAH00456.1 BC016867 mRNA Translation: AAH16867.1 BC069207 mRNA Translation: AAH69207.1 BC105277 mRNA Translation: AAI05278.1 BC136475 mRNA Translation: AAI36476.1 BC136482 mRNA Translation: AAI36483.1 BC146664 mRNA Translation: AAI46665.1 BC146679 mRNA Translation: AAI46680.1 |
CCDSi | CCDS31966.1 [Q15714-1] CCDS58291.1 [Q15714-4] CCDS9392.1 [Q15714-2] |
PIRi | JC4813 |
RefSeqi | NP_001230728.1, NM_001243799.1 [Q15714-4] NP_006013.1, NM_006022.3 [Q15714-2] NP_904358.2, NM_183422.3 [Q15714-1] |
3D structure databases
SMRi | Q15714 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114374, 96 interactors |
IntActi | Q15714, 53 interactors |
MINTi | Q15714 |
STRINGi | 9606.ENSP00000397435 |
PTM databases
iPTMneti | Q15714 |
MetOSitei | Q15714 |
PhosphoSitePlusi | Q15714 |
Genetic variation databases
BioMutai | TSC22D1 |
DMDMi | 334302874 |
Proteomic databases
EPDi | Q15714 |
jPOSTi | Q15714 |
MassIVEi | Q15714 |
MaxQBi | Q15714 |
PaxDbi | Q15714 |
PeptideAtlasi | Q15714 |
PRIDEi | Q15714 |
ProteomicsDBi | 3607 60713 [Q15714-1] 60714 [Q15714-2] 60715 [Q15714-3] |
TopDownProteomicsi | Q15714-3 [Q15714-3] |
Protocols and materials databases
Antibodypediai | 23553, 439 antibodies |
Genome annotation databases
Ensembli | ENST00000261489; ENSP00000261489; ENSG00000102804 [Q15714-2] ENST00000458659; ENSP00000397435; ENSG00000102804 [Q15714-1] ENST00000501704; ENSP00000437414; ENSG00000102804 [Q15714-4] |
GeneIDi | 8848 |
KEGGi | hsa:8848 |
UCSCi | uc001uzm.5, human [Q15714-1] |
Organism-specific databases
CTDi | 8848 |
DisGeNETi | 8848 |
GeneCardsi | TSC22D1 |
HGNCi | HGNC:16826, TSC22D1 |
HPAi | ENSG00000102804, Low tissue specificity |
MIMi | 607715, gene |
neXtProti | NX_Q15714 |
OpenTargetsi | ENSG00000102804 |
PharmGKBi | PA134887618 |
VEuPathDBi | HostDB:ENSG00000102804.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4797, Eukaryota |
GeneTreei | ENSGT00940000159144 |
HOGENOMi | CLU_148757_0_0_1 |
InParanoidi | Q15714 |
OMAi | SIVNPQT |
OrthoDBi | 1602203at2759 |
PhylomeDBi | Q15714 |
TreeFami | TF318837 |
Enzyme and pathway databases
PathwayCommonsi | Q15714 |
Miscellaneous databases
BioGRID-ORCSi | 8848, 11 hits in 1020 CRISPR screens |
ChiTaRSi | TSC22D1, human |
GeneWikii | TSC22D1 |
GenomeRNAii | 8848 |
Pharosi | Q15714, Tbio |
PROi | PR:Q15714 |
RNActi | Q15714, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102804, Expressed in endothelial cell and 248 other tissues |
ExpressionAtlasi | Q15714, baseline and differential |
Genevisiblei | Q15714, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000580, TSC-22_Dip_Bun |
Pfami | View protein in Pfam PF01166, TSC22, 1 hit |
PROSITEi | View protein in PROSITE PS01289, TSC22, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | T22D1_HUMAN | |
Accessioni | Q15714Primary (citable) accession number: Q15714 Secondary accession number(s): B3KRL7 Q96JS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 31, 2011 | |
Last modified: | April 7, 2021 | |
This is version 186 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families