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UniProtKB - Q15697 (ZN174_HUMAN)
Protein
Zinc finger protein 174
Gene
ZNF174
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 326 – 348 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 405 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription cis-regulatory region binding Source: UniProtKB
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q15697 |
SignaLinki | Q15697 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 174Alternative name(s): AW-1 Zinc finger and SCAN domain-containing protein 8 |
Gene namesi | Name:ZNF174 Synonyms:ZSCAN8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12963, ZNF174 |
MIMi | 603900, gene |
neXtProti | NX_Q15697 |
VEuPathDBi | HostDB:ENSG00000103343 |
Subcellular locationi
Nucleus
Cytoskeleton
- actin cytoskeleton Source: HPA
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7727 |
OpenTargetsi | ENSG00000103343 |
PharmGKBi | PA37545 |
Miscellaneous databases
Pharosi | Q15697, Tbio |
Genetic variation databases
BioMutai | ZNF174 |
DMDMi | 3123173 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047439 | 1 – 407 | Zinc finger protein 174Add BLAST | 407 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 26 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 204 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 230 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 271 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q15697 |
jPOSTi | Q15697 |
MassIVEi | Q15697 |
MaxQBi | Q15697 |
PaxDbi | Q15697 |
PeptideAtlasi | Q15697 |
PRIDEi | Q15697 |
ProteomicsDBi | 60705 [Q15697-1] 60706 [Q15697-2] |
PTM databases
iPTMneti | Q15697 |
PhosphoSitePlusi | Q15697 |
Expressioni
Tissue specificityi
Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.
Gene expression databases
Bgeei | ENSG00000103343, Expressed in endothelial cell and 184 other tissues |
ExpressionAtlasi | Q15697, baseline and differential |
Genevisiblei | Q15697, HS |
Organism-specific databases
HPAi | ENSG00000103343, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
1 PublicationBinary interactionsi
Isoform 2 [Q15697-2]
With | #Exp. | IntAct |
---|---|---|
SCAND1 [P57086] | 3 | EBI-11158827,EBI-745846 |
ZNF24 [P17028] | 4 | EBI-11158827,EBI-707773 |
ZSCAN18 [Q8TBC5] | 3 | EBI-11158827,EBI-3919096 |
ZSCAN22 [P10073] | 3 | EBI-11158827,EBI-10178224 |
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113516, 59 interactors |
IntActi | Q15697, 19 interactors |
MINTi | Q15697 |
STRINGi | 9606.ENSP00000268655 |
Miscellaneous databases
RNActi | Q15697, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q15697 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15697 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 59 – 124 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 66 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 150 – 270 | DisorderedSequence analysisAdd BLAST | 121 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 18 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 326 – 348 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 405 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162024 |
HOGENOMi | CLU_002678_53_2_1 |
InParanoidi | Q15697 |
OMAi | AQKPFTH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q15697 |
TreeFami | TF338582 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR027778, Zfp174 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23226:SF175, PTHR23226:SF175, 1 hit |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q15697-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAKMEITLS SNTEASSKQE RHIIAKLEEK RGPPLQKNCP DPELCRQSFR
60 70 80 90 100
RFCYQEVSGP QEALSQLRQL CRQWLQPELH TKEQILELLV MEQFLTILPP
110 120 130 140 150
EIQARVRHRC PMSSKEIVTL VEDFHRASKK PKQWVAVCMQ GQKVLLEKTG
160 170 180 190 200
SQLGEQELPD FQPQTPRRDL RESSPAEPSQ AGAYDRLSPH HWEKSPLLQE
210 220 230 240 250
PTPKLAGTEA PRMRSDNKEN PQQEGAKGAK PCAVSAGRSK GNGLQNPEPR
260 270 280 290 300
GANMSEPRLS RRQVSSPNAQ KPFAHYQRHC RVEYISSPLK SHPLRELKKS
310 320 330 340 350
KGGKRSLSNR LQHLGHQPTR SAKKPYKCDD CGKSFTWNSE LKRHKRVHTG
360 370 380 390 400
ERPYTCGECG NCFGRQSTLK LHQRIHTGEK PYQCGQCGKS FRQSSNLHQH
HRLHHGD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketI3L2H2 | I3L2H2_HUMAN | Zinc finger protein 174 | ZNF174 | 249 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006897 | 210 – 234 | APRMR…KPCAV → LLIEKTDPNMATDELPCKLW LSFIA in isoform 2. 2 PublicationsAdd BLAST | 25 | |
Alternative sequenceiVSP_006898 | 235 – 407 | Missing in isoform 2. 2 PublicationsAdd BLAST | 173 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31248 mRNA Translation: AAB04897.1 BT006923 mRNA Translation: AAP35569.1 BC000876 mRNA Translation: AAH00876.1 BC001161 mRNA Translation: AAH01161.1 |
CCDSi | CCDS10504.1 [Q15697-1] CCDS32380.1 [Q15697-2] |
PIRi | I39152 |
RefSeqi | NP_001027463.1, NM_001032292.2 [Q15697-2] NP_001334797.1, NM_001347868.1 [Q15697-1] NP_003441.1, NM_003450.2 [Q15697-1] |
Genome annotation databases
Ensembli | ENST00000268655; ENSP00000268655; ENSG00000103343 ENST00000344823; ENSP00000339781; ENSG00000103343 [Q15697-2] ENST00000571936; ENSP00000460397; ENSG00000103343 ENST00000575752; ENSP00000461502; ENSG00000103343 [Q15697-2] |
GeneIDi | 7727 |
KEGGi | hsa:7727 |
MANE-Selecti | ENST00000268655.5; ENSP00000268655.4; NM_003450.3; NP_003441.1 |
UCSCi | uc002cvb.4, human [Q15697-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31248 mRNA Translation: AAB04897.1 BT006923 mRNA Translation: AAP35569.1 BC000876 mRNA Translation: AAH00876.1 BC001161 mRNA Translation: AAH01161.1 |
CCDSi | CCDS10504.1 [Q15697-1] CCDS32380.1 [Q15697-2] |
PIRi | I39152 |
RefSeqi | NP_001027463.1, NM_001032292.2 [Q15697-2] NP_001334797.1, NM_001347868.1 [Q15697-1] NP_003441.1, NM_003450.2 [Q15697-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Y7Q | NMR | - | A/B | 37-132 | [»] | |
SMRi | Q15697 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113516, 59 interactors |
IntActi | Q15697, 19 interactors |
MINTi | Q15697 |
STRINGi | 9606.ENSP00000268655 |
PTM databases
iPTMneti | Q15697 |
PhosphoSitePlusi | Q15697 |
Genetic variation databases
BioMutai | ZNF174 |
DMDMi | 3123173 |
Proteomic databases
EPDi | Q15697 |
jPOSTi | Q15697 |
MassIVEi | Q15697 |
MaxQBi | Q15697 |
PaxDbi | Q15697 |
PeptideAtlasi | Q15697 |
PRIDEi | Q15697 |
ProteomicsDBi | 60705 [Q15697-1] 60706 [Q15697-2] |
Protocols and materials databases
ABCDi | Q15697, 2 sequenced antibodies |
Antibodypediai | 1362, 222 antibodies from 29 providers |
DNASUi | 7727 |
Genome annotation databases
Ensembli | ENST00000268655; ENSP00000268655; ENSG00000103343 ENST00000344823; ENSP00000339781; ENSG00000103343 [Q15697-2] ENST00000571936; ENSP00000460397; ENSG00000103343 ENST00000575752; ENSP00000461502; ENSG00000103343 [Q15697-2] |
GeneIDi | 7727 |
KEGGi | hsa:7727 |
MANE-Selecti | ENST00000268655.5; ENSP00000268655.4; NM_003450.3; NP_003441.1 |
UCSCi | uc002cvb.4, human [Q15697-1] |
Organism-specific databases
CTDi | 7727 |
DisGeNETi | 7727 |
GeneCardsi | ZNF174 |
HGNCi | HGNC:12963, ZNF174 |
HPAi | ENSG00000103343, Low tissue specificity |
MIMi | 603900, gene |
neXtProti | NX_Q15697 |
OpenTargetsi | ENSG00000103343 |
PharmGKBi | PA37545 |
VEuPathDBi | HostDB:ENSG00000103343 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162024 |
HOGENOMi | CLU_002678_53_2_1 |
InParanoidi | Q15697 |
OMAi | AQKPFTH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q15697 |
TreeFami | TF338582 |
Enzyme and pathway databases
PathwayCommonsi | Q15697 |
SignaLinki | Q15697 |
Miscellaneous databases
BioGRID-ORCSi | 7727, 16 hits in 1066 CRISPR screens |
ChiTaRSi | ZNF174, human |
EvolutionaryTracei | Q15697 |
GenomeRNAii | 7727 |
Pharosi | Q15697, Tbio |
PROi | PR:Q15697 |
RNActi | Q15697, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103343, Expressed in endothelial cell and 184 other tissues |
ExpressionAtlasi | Q15697, baseline and differential |
Genevisiblei | Q15697, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR027778, Zfp174 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23226:SF175, PTHR23226:SF175, 1 hit |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN174_HUMAN | |
Accessioni | Q15697Primary (citable) accession number: Q15697 Secondary accession number(s): Q53Y68, Q9BQ34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 201 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families