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Protein

Zinc finger protein 174

Gene

ZNF174

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri326 – 348C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 405C2H2-type 3PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 174
Alternative name(s):
AW-1
Zinc finger and SCAN domain-containing protein 8
Gene namesi
Name:ZNF174
Synonyms:ZSCAN8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103343.12
HGNCiHGNC:12963 ZNF174
MIMi603900 gene
neXtProtiNX_Q15697

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103343
PharmGKBiPA37545

Polymorphism and mutation databases

BioMutaiZNF174
DMDMi3123173

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474391 – 407Zinc finger protein 174Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki204Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki230Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ15697
MaxQBiQ15697
PaxDbiQ15697
PeptideAtlasiQ15697
PRIDEiQ15697
ProteomicsDBi60705
60706 [Q15697-2]

PTM databases

iPTMnetiQ15697
PhosphoSitePlusiQ15697

Expressioni

Tissue specificityi

Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.

Gene expression databases

BgeeiENSG00000103343 Expressed in 166 organ(s), highest expression level in endothelial cell
CleanExiHS_ZNF174
ExpressionAtlasiQ15697 baseline and differential
GenevisibleiQ15697 HS

Organism-specific databases

HPAiHPA009656

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZSCAN22P100734EBI-11158827,EBI-10178224

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113516, 44 interactors
IntActiQ15697, 7 interactors
STRINGi9606.ENSP00000268655

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15697
SMRiQ15697
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15697

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 124SCAN boxPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri326 – 348C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 405C2H2-type 3PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ15697
KOiK09230
OMAiCFGRQST
OrthoDBiEOG091G09O3
PhylomeDBiQ15697
TreeFamiTF338582

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR027778 Zfp174
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR45556 PTHR45556, 1 hit
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15697-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAKMEITLS SNTEASSKQE RHIIAKLEEK RGPPLQKNCP DPELCRQSFR
60 70 80 90 100
RFCYQEVSGP QEALSQLRQL CRQWLQPELH TKEQILELLV MEQFLTILPP
110 120 130 140 150
EIQARVRHRC PMSSKEIVTL VEDFHRASKK PKQWVAVCMQ GQKVLLEKTG
160 170 180 190 200
SQLGEQELPD FQPQTPRRDL RESSPAEPSQ AGAYDRLSPH HWEKSPLLQE
210 220 230 240 250
PTPKLAGTEA PRMRSDNKEN PQQEGAKGAK PCAVSAGRSK GNGLQNPEPR
260 270 280 290 300
GANMSEPRLS RRQVSSPNAQ KPFAHYQRHC RVEYISSPLK SHPLRELKKS
310 320 330 340 350
KGGKRSLSNR LQHLGHQPTR SAKKPYKCDD CGKSFTWNSE LKRHKRVHTG
360 370 380 390 400
ERPYTCGECG NCFGRQSTLK LHQRIHTGEK PYQCGQCGKS FRQSSNLHQH

HRLHHGD
Length:407
Mass (Da):46,455
Last modified:November 1, 1996 - v1
Checksum:i1FAB4A631EA2ABCC
GO
Isoform 2 (identifier: Q15697-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-234: APRMRSDNKENPQQEGAKGAKPCAV → LLIEKTDPNMATDELPCKLWLSFIA
     235-407: Missing.

Show »
Length:234
Mass (Da):26,884
Checksum:iA2A40D0A1AA96BC6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2H2I3L2H2_HUMAN
Zinc finger protein 174
ZNF174
249Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006897210 – 234APRMR…KPCAV → LLIEKTDPNMATDELPCKLW LSFIA in isoform 2. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_006898235 – 407Missing in isoform 2. 2 PublicationsAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31248 mRNA Translation: AAB04897.1
BT006923 mRNA Translation: AAP35569.1
BC000876 mRNA Translation: AAH00876.1
BC001161 mRNA Translation: AAH01161.1
CCDSiCCDS10504.1 [Q15697-1]
CCDS32380.1 [Q15697-2]
PIRiI39152
RefSeqiNP_001027463.1, NM_001032292.2 [Q15697-2]
NP_001334797.1, NM_001347868.1 [Q15697-1]
NP_003441.1, NM_003450.2 [Q15697-1]
UniGeneiHs.155204

Genome annotation databases

EnsembliENST00000268655; ENSP00000268655; ENSG00000103343 [Q15697-1]
ENST00000344823; ENSP00000339781; ENSG00000103343 [Q15697-2]
ENST00000571936; ENSP00000460397; ENSG00000103343 [Q15697-1]
ENST00000575752; ENSP00000461502; ENSG00000103343 [Q15697-2]
GeneIDi7727
KEGGihsa:7727
UCSCiuc002cvb.4 human [Q15697-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31248 mRNA Translation: AAB04897.1
BT006923 mRNA Translation: AAP35569.1
BC000876 mRNA Translation: AAH00876.1
BC001161 mRNA Translation: AAH01161.1
CCDSiCCDS10504.1 [Q15697-1]
CCDS32380.1 [Q15697-2]
PIRiI39152
RefSeqiNP_001027463.1, NM_001032292.2 [Q15697-2]
NP_001334797.1, NM_001347868.1 [Q15697-1]
NP_003441.1, NM_003450.2 [Q15697-1]
UniGeneiHs.155204

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y7QNMR-A/B37-132[»]
ProteinModelPortaliQ15697
SMRiQ15697
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113516, 44 interactors
IntActiQ15697, 7 interactors
STRINGi9606.ENSP00000268655

PTM databases

iPTMnetiQ15697
PhosphoSitePlusiQ15697

Polymorphism and mutation databases

BioMutaiZNF174
DMDMi3123173

Proteomic databases

EPDiQ15697
MaxQBiQ15697
PaxDbiQ15697
PeptideAtlasiQ15697
PRIDEiQ15697
ProteomicsDBi60705
60706 [Q15697-2]

Protocols and materials databases

DNASUi7727
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268655; ENSP00000268655; ENSG00000103343 [Q15697-1]
ENST00000344823; ENSP00000339781; ENSG00000103343 [Q15697-2]
ENST00000571936; ENSP00000460397; ENSG00000103343 [Q15697-1]
ENST00000575752; ENSP00000461502; ENSG00000103343 [Q15697-2]
GeneIDi7727
KEGGihsa:7727
UCSCiuc002cvb.4 human [Q15697-1]

Organism-specific databases

CTDi7727
EuPathDBiHostDB:ENSG00000103343.12
GeneCardsiZNF174
HGNCiHGNC:12963 ZNF174
HPAiHPA009656
MIMi603900 gene
neXtProtiNX_Q15697
OpenTargetsiENSG00000103343
PharmGKBiPA37545
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ15697
KOiK09230
OMAiCFGRQST
OrthoDBiEOG091G09O3
PhylomeDBiQ15697
TreeFamiTF338582

Miscellaneous databases

ChiTaRSiZNF174 human
EvolutionaryTraceiQ15697
GenomeRNAii7727
PROiPR:Q15697
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103343 Expressed in 166 organ(s), highest expression level in endothelial cell
CleanExiHS_ZNF174
ExpressionAtlasiQ15697 baseline and differential
GenevisibleiQ15697 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR027778 Zfp174
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR45556 PTHR45556, 1 hit
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN174_HUMAN
AccessioniPrimary (citable) accession number: Q15697
Secondary accession number(s): Q53Y68, Q9BQ34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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