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Entry version 221 (29 Sep 2021)
Sequence version 3 (23 Jan 2007)
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Protein

Microtubule-associated protein RP/EB family member 1

Gene

MAPRE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570).

Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570).

May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:12388762).

Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570).

Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570).

Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242).

May play a role in cell migration (By similarity).

By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q15691

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-68877, Mitotic Prometaphase
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854518, AURKA Activation by TPX2
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation

SIGNOR Signaling Network Open Resource

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SIGNORi
Q15691

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein RP/EB family member 1
Alternative name(s):
APC-binding protein EB1
End-binding protein 1
Short name:
EB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAPRE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6890, MAPRE1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603108, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q15691

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000101367

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi59 – 60KK → EE: No effect. 1 Publication2
Mutagenesisi89K → E: Loss of binding to microtubules. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
22919

Open Targets

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OpenTargetsi
ENSG00000101367

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30634

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q15691, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MAPRE1

Domain mapping of disease mutations (DMDM)

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DMDMi
20138589

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002134162 – 268Microtubule-associated protein RP/EB family member 1Add BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei124PhosphotyrosineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15691

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15691

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15691

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15691

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15691

PeptideAtlas

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PeptideAtlasi
Q15691

PRoteomics IDEntifications database

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PRIDEi
Q15691

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60702

2D gel databases

USC-OGP 2-DE database

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OGPi
Q15691

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00017596

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q15691, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15691

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q15691

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15691

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q15691

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101367, Expressed in secondary oocyte and 245 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15691, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000101367, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:15616574). Heterodimer with MAPRE3 (PubMed:19255245).

Interacts with DCTN1, DCTN2, TERF1 and dynein intermediate chain (PubMed:10226031, PubMed:11943150, PubMed:12388762, PubMed:14514668, PubMed:23874158, PubMed:16109370, PubMed:16949363). Interaction with DIAPH1 and DIAPH2 (By similarity).

Interacts with APC (via C-terminal domain), CLASP2, DST, KIF2C and STIM1; probably required for their targeting to the growing microtubule plus ends (PubMed:7606712, PubMed:12388762, PubMed:14514668, PubMed:15631994, PubMed:19543227, PubMed:15616574, PubMed:19632184).

Interacts with MTUS2; interaction is direct and probably targets MTUS2 to microtubules (PubMed:19543227).

Interacts with APC2 (PubMed:10644998).

Interacts with CLASP1 (PubMed:15631994).

Interacts with CDK5RAP2 (PubMed:19553473).

Interacts with MACF1 (By similarity).

Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity).

Interacts with KCNAB2 (By similarity).

Interacts (via C-terminus) with CLIP1 (PubMed:17563362, PubMed:21646404).

Interacts with SLAIN2 and SLAIN1 (PubMed:21646404).

Interacts with KIF18B; this interaction is required for efficient accumulation of KIF18B at microtubule plus ends (PubMed:21820309).

Interacts with MISP (PubMed:23509069).

Interacts with KNSTRN (PubMed:23035123).

Interacts with NCKAP5L (PubMed:26485573).

Interacts with CAMSAP2 (PubMed:28726242).

Interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus (PubMed:25217626, PubMed:28814570).

Forms a pericentrosomal complex with AKAP9, CDK5RAP2 and PDE4DIP isoform 13/MMG8/SMYLE; within this complex, MAPRE1 binding to CDK5RAP2 may be mediated by PDE4DIP (PubMed:29162697).

Interacts with AKNA (By similarity).

Interacts with GAS2L1, GAS2L2, and GAS2L3 (PubMed:24706950).

Interacts with RARRES1 and AGBL2 (PubMed:21303978).

By similarity27 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116581, 217 interactors

Database of interacting proteins

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DIPi
DIP-38018N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q15691

Protein interaction database and analysis system

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IntActi
Q15691, 145 interactors

Molecular INTeraction database

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MINTi
Q15691

STRING: functional protein association networks

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STRINGi
9606.ENSP00000364721

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q15691, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

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BMRBi
Q15691

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15691

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15691

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 116Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST103
Domaini185 – 255EB1 C-terminalPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 268Interaction with MTUS2/TIP1501 PublicationAdd BLAST145
Regioni146 – 187DisorderedSequence analysisAdd BLAST42
Regioni185 – 268Interaction with CDK5RAP21 PublicationAdd BLAST84
Regioni208 – 268DCTN1-bindingAdd BLAST61
Regioni220 – 242APC-bindingAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi150 – 168Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAPRE family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3000, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00490000043329

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_041744_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15691

Identification of Orthologs from Complete Genome Data

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OMAi
MDMIHPG

Database of Orthologous Groups

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OrthoDBi
1237523at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15691

TreeFam database of animal gene trees

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TreeFami
TF313620

Family and domain databases

Database of protein disorder

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DisProti
DP01271

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR004953, EB1_C
IPR036133, EB1_C_sf
IPR027739, EB1_Meta
IPR027328, MAPRE

The PANTHER Classification System

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PANTHERi
PTHR10623, PTHR10623, 1 hit
PTHR10623:SF20, PTHR10623:SF20, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF03271, EB1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140612, SSF140612, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS51230, EB1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q15691-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVNVYSTSV TSDNLSRHDM LAWINESLQL NLTKIEQLCS GAAYCQFMDM
60 70 80 90 100
LFPGSIALKK VKFQAKLEHE YIQNFKILQA GFKRMGVDKI IPVDKLVKGK
110 120 130 140 150
FQDNFEFVQW FKKFFDANYD GKDYDPVAAR QGQETAVAPS LVAPALNKPK
160 170 180 190 200
KPLTSSSAAP QRPISTQRTA AAPKAGPGVV RKNPGVGNGD DEAAELMQQV
210 220 230 240 250
NVLKLTVEDL EKERDFYFGK LRNIELICQE NEGENDPVLQ RIVDILYATD
260
EGFVIPDEGG PQEEQEEY
Length:268
Mass (Da):29,999
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08C8999F45A145ED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U24166 mRNA Translation: AAC09471.1
AK312590 mRNA Translation: BAG35484.1
AL035071 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76348.1
CH471077 Genomic DNA Translation: EAW76349.1
BC106068 mRNA Translation: AAI06069.1
BC109281 mRNA Translation: AAI09282.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13208.1

Protein sequence database of the Protein Information Resource

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PIRi
I52726

NCBI Reference Sequences

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RefSeqi
NP_036457.1, NM_012325.2
XP_011526998.1, XM_011528696.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000375571; ENSP00000364721; ENSG00000101367

Database of genes from NCBI RefSeq genomes

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GeneIDi
22919

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22919

UCSC genome browser

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UCSCi
uc002wyh.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24166 mRNA Translation: AAC09471.1
AK312590 mRNA Translation: BAG35484.1
AL035071 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76348.1
CH471077 Genomic DNA Translation: EAW76349.1
BC106068 mRNA Translation: AAI06069.1
BC109281 mRNA Translation: AAI09282.1
CCDSiCCDS13208.1
PIRiI52726
RefSeqiNP_036457.1, NM_012325.2
XP_011526998.1, XM_011528696.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PA7X-ray1.45A1-130[»]
1TXQX-ray1.80B183-268[»]
1UEGX-ray2.40A1-130[»]
1VKAX-ray1.60A/B2-140[»]
1WU9X-ray1.54A/B191-268[»]
1YIBX-ray1.80A185-255[»]
1YIGX-ray2.00A/B185-255[»]
2HKQX-ray1.86A191-268[»]
2HL3X-ray2.03C263-268[»]
2HL5X-ray1.93A/B191-268[»]
2QJZX-ray1.25A/B12-133[»]
2R8UX-ray1.35A/B1-268[»]
3GJOX-ray2.50A/B/C/D191-260[»]
3MTUX-ray2.10A/B/C/D215-257[»]
3MUDX-ray2.20C/D226-257[»]
3TQ7X-ray2.30A191-268[»]
4XA1X-ray3.20A/B/C/D211-251[»]
4XA3X-ray2.55A/B215-251[»]
4XA6X-ray3.42A/B/C/D209-251[»]
5JV3X-ray2.01A/B/C/D210-257[»]
5JVMX-ray1.57A/B207-257[»]
5JVPX-ray2.10A/B/C/D/E/F210-257[»]
5JVRX-ray2.10A/B/C/D/E/F/G/H207-257[»]
5JVSX-ray2.25A207-257[»]
5JVUX-ray1.95A/B207-257[»]
5JX1X-ray1.67A210-257[»]
5WLQX-ray3.10A208-257[»]
6PF2X-ray2.17A/B207-257[»]
6PFPX-ray2.20A/B/C/D207-257[»]
6YF5X-ray1.83A/B/C/D215-251[»]
6YSHX-ray2.83A215-251[»]
B215-250[»]
BMRBiQ15691
SMRiQ15691
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116581, 217 interactors
DIPiDIP-38018N
ELMiQ15691
IntActiQ15691, 145 interactors
MINTiQ15691
STRINGi9606.ENSP00000364721

PTM databases

GlyGeniQ15691, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ15691
MetOSiteiQ15691
PhosphoSitePlusiQ15691
SwissPalmiQ15691

Genetic variation databases

BioMutaiMAPRE1
DMDMi20138589

2D gel databases

OGPiQ15691
REPRODUCTION-2DPAGEiIPI00017596

Proteomic databases

EPDiQ15691
jPOSTiQ15691
MassIVEiQ15691
MaxQBiQ15691
PaxDbiQ15691
PeptideAtlasiQ15691
PRIDEiQ15691
ProteomicsDBi60702

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1211, 276 antibodies

The DNASU plasmid repository

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DNASUi
22919

Genome annotation databases

EnsembliENST00000375571; ENSP00000364721; ENSG00000101367
GeneIDi22919
KEGGihsa:22919
UCSCiuc002wyh.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22919
DisGeNETi22919

GeneCards: human genes, protein and diseases

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GeneCardsi
MAPRE1
HGNCiHGNC:6890, MAPRE1
HPAiENSG00000101367, Low tissue specificity
MIMi603108, gene
neXtProtiNX_Q15691
OpenTargetsiENSG00000101367
PharmGKBiPA30634
VEuPathDBiHostDB:ENSG00000101367

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3000, Eukaryota
GeneTreeiENSGT00490000043329
HOGENOMiCLU_041744_1_1_1
InParanoidiQ15691
OMAiMDMIHPG
OrthoDBi1237523at2759
PhylomeDBiQ15691
TreeFamiTF313620

Enzyme and pathway databases

PathwayCommonsiQ15691
ReactomeiR-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-68877, Mitotic Prometaphase
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854518, AURKA Activation by TPX2
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
SIGNORiQ15691

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
22919, 120 hits in 1021 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAPRE1, human
EvolutionaryTraceiQ15691

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MAPRE1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22919
PharosiQ15691, Tbio

Protein Ontology

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PROi
PR:Q15691
RNActiQ15691, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101367, Expressed in secondary oocyte and 245 other tissues
GenevisibleiQ15691, HS

Family and domain databases

DisProtiDP01271
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR004953, EB1_C
IPR036133, EB1_C_sf
IPR027739, EB1_Meta
IPR027328, MAPRE
PANTHERiPTHR10623, PTHR10623, 1 hit
PTHR10623:SF20, PTHR10623:SF20, 1 hit
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF03271, EB1, 1 hit
SUPFAMiSSF140612, SSF140612, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS51230, EB1_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARE1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15691
Secondary accession number(s): B2R6I7, E1P5M8, Q3KQS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 221 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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