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Protein

Tryptase alpha/beta-1

Gene

TPSAB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin. EC:3.4.21.59

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei74Charge relay system1
Active sitei121Charge relay system1
Active sitei224Charge relay system1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • serine-type endopeptidase activity Source: GO_Central
  • serine-type peptidase activity Source: ProtInc

GO - Biological processi

  • defense response Source: ProtInc
  • extracellular matrix disassembly Source: BHF-UCL
  • proteolysis Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.59 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1592389 Activation of Matrix Metalloproteinases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q15661

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tryptase alpha/beta-1 (EC:3.4.21.59)
Short name:
Tryptase-1
Alternative name(s):
Tryptase I
Tryptase alpha-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPSAB1
Synonyms:TPS1, TPS2, TPSB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000172236.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12019 TPSAB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
191080 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15661

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64499
7177

Open Targets

More...
OpenTargetsi
ENSG00000172236

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36698

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2617

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2424

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
18202508

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002747919 – 30Activation peptideBy similarityAdd BLAST12
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002748031 – 275Tryptase alpha/beta-1Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi59 ↔ 75
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi155 ↔ 230
Disulfide bondi188 ↔ 211
Disulfide bondi220 ↔ 248
Glycosylationi233N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15661

PeptideAtlas

More...
PeptideAtlasi
Q15661

PRoteomics IDEntifications database

More...
PRIDEi
Q15661

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60697
60698 [Q15661-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1861

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15661

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15661

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172236 Expressed in 141 organ(s), highest expression level in fundus of stomach

CleanEx database of gene expression profiles

More...
CleanExi
HS_TPSAB1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15661 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15661 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016369
CAB022175
HPA049153
HPA049554

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113029, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q15661, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343577

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q15661

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q15661

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15661

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15661

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 272Peptidase S1PROSITE-ProRule annotationAdd BLAST242

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Tryptase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627 Eukaryota
COG5640 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000164974

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG013304

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15661

KEGG Orthology (KO)

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KOi
K01340

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15661

TreeFam database of animal gene trees

More...
TreeFami
TF351676

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00190 Tryp_SPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00089 Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15661-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV
60 70 80 90 100
HGPYWMHFCG GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ
110 120 130 140 150
LLPVSRIIVH PQFYTAQIGA DIALLELEEP VNVSSHVHTV TLPPASETFP
160 170 180 190 200
PGMPCWVTGW GDVDNDERLP PPFPLKQVKV PIMENHICDA KYHLGAYTGD
210 220 230 240 250
DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG VVSWGEGCAQ
260 270
PNRPGIYTRV TYYLDWIHHY VPKKP
Length:275
Mass (Da):30,515
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADC48FDC51F37112
GO
Isoform 2 (identifier: Q15661-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-87: Missing.

Show »
Length:266
Mass (Da):29,533
Checksum:i04F79FEB4ABF517D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QTS8J3QTS8_HUMAN
Tryptase alpha/beta-1
TPSAB1
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGM1A0A0C4DGM1_HUMAN
Tryptase alpha/beta-1
TPSAB1
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129E → K in ACZ98912 (PubMed:19748655).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There are two alleles alpha and beta-I. The sequence shown is that of allele beta-I.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0642773N → S in allele alpha. Corresponds to variant dbSNP:rs371929937Ensembl.1
Natural variantiVAR_06427815R → P3 PublicationsCorresponds to variant dbSNP:rs761476435Ensembl.1
Natural variantiVAR_01455718A → V1 PublicationCorresponds to variant dbSNP:rs562518617Ensembl.1
Natural variantiVAR_01455823G → V in allele alpha. 1 PublicationCorresponds to variant dbSNP:rs141519544Ensembl.1
Natural variantiVAR_06427928R → Q in allele alpha. Corresponds to variant dbSNP:rs146223687Ensembl.1
Natural variantiVAR_06428029V → A in allele alpha. Corresponds to variant dbSNP:rs112944038Ensembl.1
Natural variantiVAR_06428151H → R in allele alpha. Corresponds to variant dbSNP:rs1060281Ensembl.1
Natural variantiVAR_06428252G → D in allele alpha. Corresponds to variant dbSNP:rs17841227Ensembl.1
Natural variantiVAR_06428353P → R in allele alpha. Corresponds to variant dbSNP:rs17841226Ensembl.1
Natural variantiVAR_06428476V → L in allele alpha. Corresponds to variant dbSNP:rs151324823Ensembl.1
Natural variantiVAR_01455985A → T3 PublicationsCorresponds to variant dbSNP:rs201351744Ensembl.1
Natural variantiVAR_064285115T → I in allele alpha. Corresponds to variant dbSNP:rs199625169Ensembl.1
Natural variantiVAR_064286116A → I in allele alpha; requires 2 nucleotide substitutions. 1
Natural variantiVAR_064287118I → T in allele alpha. Corresponds to variant dbSNP:rs202044288Ensembl.1
Natural variantiVAR_016102132N → K2 PublicationsCorresponds to variant dbSNP:rs144979264Ensembl.1
Natural variantiVAR_064288133V → I in allele alpha. Corresponds to variant dbSNP:rs200334042Ensembl.1
Natural variantiVAR_051830136H → R in allele alpha. Corresponds to variant dbSNP:rs1064780Ensembl.1
Natural variantiVAR_014560141T → A1 PublicationCorresponds to variant dbSNP:rs1800992Ensembl.1
Natural variantiVAR_064289141T → M in allele alpha. 1
Natural variantiVAR_014561162D → N1 PublicationCorresponds to variant dbSNP:rs143210825Ensembl.1
Natural variantiVAR_064290168R → P in allele alpha. Corresponds to variant dbSNP:rs202156919Ensembl.1
Natural variantiVAR_014562170P → S2 PublicationsCorresponds to variant dbSNP:rs201345428Ensembl.1
Natural variantiVAR_064291205V → I in allele alpha. Corresponds to variant dbSNP:rs1060284Ensembl.1
Natural variantiVAR_014563215T → S3 PublicationsCorresponds to variant dbSNP:rs2234905Ensembl.1
Natural variantiVAR_014564216R → Q3 PublicationsCorresponds to variant dbSNP:rs2234906Ensembl.1
Natural variantiVAR_064292221Q → K3 PublicationsCorresponds to variant dbSNP:rs201192435Ensembl.1
Natural variantiVAR_064293245G → D in allele alpha. Corresponds to variant dbSNP:rs145402040Ensembl.1
Natural variantiVAR_064294263Y → N1 PublicationCorresponds to variant dbSNP:rs200355084Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00537579 – 87Missing in isoform 2. Curated9

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M30038 mRNA Translation: AAA86934.1
M33494 Genomic DNA Translation: AAC83172.1
M33491 mRNA Translation: AAA36778.1
AF098328 Genomic DNA Translation: AAD17846.1
AF099144 Genomic DNA Translation: AAD17860.1
AF206665 mRNA Translation: AAG35695.1
AF206666 mRNA Translation: AAG35696.1
AF206667 mRNA Translation: AAG35697.1
FJ931116 Genomic DNA Translation: ACZ98910.1
FJ931118 mRNA Translation: ACZ98912.1
AC120498 Genomic DNA No translation available.
BC074974 mRNA Translation: AAH74974.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10431.1 [Q15661-1]

Protein sequence database of the Protein Information Resource

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PIRi
A35863
A45754
C35863

NCBI Reference Sequences

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RefSeqi
NP_003285.2, NM_003294.3 [Q15661-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.405479
Hs.592982

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000338844; ENSP00000343577; ENSG00000172236 [Q15661-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7177

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7177

UCSC genome browser

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UCSCi
uc002ckz.4 human [Q15661-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30038 mRNA Translation: AAA86934.1
M33494 Genomic DNA Translation: AAC83172.1
M33491 mRNA Translation: AAA36778.1
AF098328 Genomic DNA Translation: AAD17846.1
AF099144 Genomic DNA Translation: AAD17860.1
AF206665 mRNA Translation: AAG35695.1
AF206666 mRNA Translation: AAG35696.1
AF206667 mRNA Translation: AAG35697.1
FJ931116 Genomic DNA Translation: ACZ98910.1
FJ931118 mRNA Translation: ACZ98912.1
AC120498 Genomic DNA No translation available.
BC074974 mRNA Translation: AAH74974.1
CCDSiCCDS10431.1 [Q15661-1]
PIRiA35863
A45754
C35863
RefSeqiNP_003285.2, NM_003294.3 [Q15661-1]
UniGeneiHs.405479
Hs.592982

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LTOX-ray2.20A/B/C/D31-275[»]
2F9NX-ray1.60A/B/C/D31-275[»]
2F9OX-ray2.10A/B/C/D31-275[»]
2F9PX-ray2.30A/B/C/D31-275[»]
2ZEBX-ray2.50A/B/C/D31-273[»]
2ZECX-ray2.06A/B/C/D31-273[»]
4A6LX-ray2.05A/B/C/D31-275[»]
4MPUX-ray1.65A/B31-275[»]
4MPVX-ray2.31A/B31-275[»]
4MPWX-ray1.95A/B31-275[»]
4MPXX-ray2.00A/B31-275[»]
4MQAX-ray2.25A/B31-275[»]
5F03X-ray1.94A/B31-275[»]
5WI6X-ray2.72A/B/C/D31-275[»]
ProteinModelPortaliQ15661
SMRiQ15661
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113029, 2 interactors
IntActiQ15661, 2 interactors
STRINGi9606.ENSP00000343577

Chemistry databases

BindingDBiQ15661
ChEMBLiCHEMBL2617
GuidetoPHARMACOLOGYi2424

Protein family/group databases

MEROPSiS01.143

PTM databases

GlyConnecti1861
iPTMnetiQ15661
PhosphoSitePlusiQ15661

Polymorphism and mutation databases

DMDMi18202508

Proteomic databases

PaxDbiQ15661
PeptideAtlasiQ15661
PRIDEiQ15661
ProteomicsDBi60697
60698 [Q15661-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7177
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338844; ENSP00000343577; ENSG00000172236 [Q15661-1]
GeneIDi7177
KEGGihsa:7177
UCSCiuc002ckz.4 human [Q15661-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7177
DisGeNETi64499
7177
EuPathDBiHostDB:ENSG00000172236.16

GeneCards: human genes, protein and diseases

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GeneCardsi
TPSAB1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0012676
HGNCiHGNC:12019 TPSAB1
HPAiCAB016369
CAB022175
HPA049153
HPA049554
MIMi191080 gene
neXtProtiNX_Q15661
OpenTargetsiENSG00000172236
PharmGKBiPA36698

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000164974
HOVERGENiHBG013304
InParanoidiQ15661
KOiK01340
PhylomeDBiQ15661
TreeFamiTF351676

Enzyme and pathway databases

BRENDAi3.4.21.59 2681
ReactomeiR-HSA-1592389 Activation of Matrix Metalloproteinases
SIGNORiQ15661

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TPSAB1 human
EvolutionaryTraceiQ15661

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7177

Protein Ontology

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PROi
PR:Q15661

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172236 Expressed in 141 organ(s), highest expression level in fundus of stomach
CleanExiHS_TPSAB1
ExpressionAtlasiQ15661 baseline and differential
GenevisibleiQ15661 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRYB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15661
Secondary accession number(s): D2E6R9
, D2E6S1, P15157, Q15663, Q6B052, Q9H2Y4, Q9H2Y5, Q9UQI1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: December 5, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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