UniProtKB - Q15654 (TRIP6_HUMAN)
Thyroid receptor-interacting protein 6
TRIP6
Functioni
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
4 PublicationsGO - Molecular functioni
- interleukin-1 receptor binding Source: UniProtKB
- kinase binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- thyroid hormone receptor binding Source: UniProtKB
GO - Biological processi
- chordate embryonic development Source: Ensembl
- focal adhesion assembly Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of NIK/NF-kappaB signaling Source: UniProtKB
- signal transduction Source: GO_Central
Keywordsi
Biological process | Cell adhesion, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q15654 |
SignaLinki | Q15654 |
SIGNORi | Q15654 |
Names & Taxonomyi
Protein namesi | Recommended name: Thyroid receptor-interacting protein 6Short name: TR-interacting protein 6 Short name: TRIP-6 Alternative name(s): Opa-interacting protein 1 Short name: OIP-1 Zyxin-related protein 1 Short name: ZRP-1 |
Gene namesi | Name:TRIP6 Synonyms:OIP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12311, TRIP6 |
MIMi | 602933, gene |
neXtProti | NX_Q15654 |
VEuPathDBi | HostDB:ENSG00000087077 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Nucleus
- Nucleus 2 Publications
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- focal adhesion 1 Publication
Note: Shuttles between nucleus and cytoplasm (PubMed:16624523). Colocalizes with actin (PubMed:10826496).2 Publications
Cytoskeleton
- cytoskeleton Source: UniProtKB
- stress fiber Source: GO_Central
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: GO_Central
- focal adhesion Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 101 | S → A: Exclusively located in nucleus. 1 Publication | 1 | |
Mutagenesisi | 102 | S → A: Exclusively located in nucleus. 1 Publication | 1 | |
Mutagenesisi | 474 | T → A: Reduces interaction with MAGI1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7205 |
OpenTargetsi | ENSG00000087077 |
PharmGKBi | PA36989 |
Miscellaneous databases
Pharosi | Q15654, Tbio |
Genetic variation databases
BioMutai | TRIP6 |
DMDMi | 20981729 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075908 | 1 – 476 | Thyroid receptor-interacting protein 6Add BLAST | 476 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 25 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 55 | Phosphotyrosine; by SRC2 Publications | 1 | |
Modified residuei | 92 | PhosphoserineCombined sources | 1 | |
Modified residuei | 111 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 142 | PhosphoserineCombined sources | 1 | |
Modified residuei | 179 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 186 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 189 | PhosphoserineCombined sources | 1 | |
Modified residuei | 205 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 236 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 238 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 249 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q15654 |
jPOSTi | Q15654 |
MassIVEi | Q15654 |
MaxQBi | Q15654 |
PaxDbi | Q15654 |
PeptideAtlasi | Q15654 |
PRIDEi | Q15654 |
ProteomicsDBi | 24045 24046 60696 [Q15654-1] |
PTM databases
GlyGeni | Q15654, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15654 |
PhosphoSitePlusi | Q15654 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000087077, Expressed in myometrium and 232 other tissues |
ExpressionAtlasi | Q15654, baseline and differential |
Genevisiblei | Q15654, HS |
Organism-specific databases
HPAi | ENSG00000087077, Low tissue specificity |
Interactioni
Subunit structurei
Specifically interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone (PubMed:14688263).
Interacts (via the third LIM domain and C-terminus) with PTPN13 (via the second PDZ domain) (PubMed:10400701, PubMed:17591779, PubMed:19017743, PubMed:10826496).
Interacts (via the second LIM domain or via the third LIM domain plus C-terminus) with PDLIM4 (via PDZ domain) (PubMed:10826496).
Found in a complex with PTPN13 and PDLIM4 (By similarity).
Interacts with SVIL isoform 2 (PubMed:16880273).
Interacts with LPAR2 but not other LPA receptors (PubMed:14688263).
Interacts with PRKAA2 (PubMed:16624523).
Interacts with MAGI1 (PubMed:19017743).
Interacts with SCRIB (PubMed:16137684). In case of infection, interacts with S.typhimurium protein sseI (PubMed:17095609).
By similarity9 PublicationsBinary interactionsi
Q15654
GO - Molecular functioni
- interleukin-1 receptor binding Source: UniProtKB
- kinase binding Source: UniProtKB
- thyroid hormone receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113056, 326 interactors |
CORUMi | Q15654 |
DIPi | DIP-34466N |
IntActi | Q15654, 221 interactors |
MINTi | Q15654 |
STRINGi | 9606.ENSP00000200457 |
Miscellaneous databases
RNActi | Q15654, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q15654 |
SMRi | Q15654 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15654 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 279 – 316 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 339 – 398 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 399 – 467 | LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 93 | DisorderedSequence analysisAdd BLAST | 93 | |
Regioni | 108 – 253 | DisorderedSequence analysisAdd BLAST | 146 | |
Regioni | 469 – 476 | Interaction with MAGI1 and PTPN131 Publication | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 15 | Pro residuesSequence analysisAdd BLAST | 15 |
Domaini
Sequence similaritiesi
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG1701, Eukaryota |
GeneTreei | ENSGT00940000154273 |
HOGENOMi | CLU_001357_10_1_1 |
InParanoidi | Q15654 |
OMAi | SMGYPPH |
OrthoDBi | 483341at2759 |
PhylomeDBi | Q15654 |
TreeFami | TF320310 |
Family and domain databases
InterProi | View protein in InterPro IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 3 hits |
SMARTi | View protein in SMART SM00132, LIM, 3 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGPTWLPPK QPEPARAPQG RAIPRGTPGP PPAHGAALQP HPRVNFCPLP
60 70 80 90 100
SEQCYQAPGG PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL
110 120 130 140 150
SSTLAELNGG RGHASRRPDR QAYEPPPPPA YRTGSLKPNP ASPLPASPYG
160 170 180 190 200
GPTPASYTTA STPAGPAFPV QVKVAQPVRG CGPPRRGASQ ASGPLPGPHF
210 220 230 240 250
PLPGRGEVWG PGYRSQREPG PGAKEEAAGV SGPAGRGRGG EHGPQVPLSQ
260 270 280 290 300
PPEDELDRLT KKLVHDMNHP PSGEYFGQCG GCGEDVVGDG AGVVALDRVF
310 320 330 340 350
HVGCFVCSTC RAQLRGQHFY AVERRAYCEG CYVATLEKCA TCSQPILDRI
360 370 380 390 400
LRAMGKAYHP GCFTCVVCHR GLDGIPFTVD ATSQIHCIED FHRKFAPRCS
410 420 430 440 450
VCGGAIMPEP GQEETVRIVA LDRSFHIGCY KCEECGLLLS SEGECQGCYP
460 470
LDGHILCKAC SAWRIQELSA TVTTDC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7BZE2 | H7BZE2_HUMAN | Thyroid receptor-interacting protei... | TRIP6 | 215 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 39 – 40 | Missing in AAH02680 (PubMed:15489334).Curated | 2 | |
Sequence conflicti | 102 | S → T in AAB62222 (PubMed:10400701).Curated | 1 | |
Sequence conflicti | 106 | E → K in AAB62222 (PubMed:10400701).Curated | 1 | |
Sequence conflicti | 135 | S → C in CAA05080 (PubMed:9598321).Curated | 1 | |
Sequence conflicti | 310 – 313 | CRAQ → MPGP in AAC41740 (PubMed:7776974).Curated | 4 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062262 | 111 | R → Q1 PublicationCorresponds to variant dbSNP:rs2437100Ensembl. | 1 | |
Natural variantiVAR_050171 | 230 | V → I1 PublicationCorresponds to variant dbSNP:rs2075756Ensembl. | 1 | |
Natural variantiVAR_013309 | 296 | L → F1 PublicationCorresponds to variant dbSNP:rs17855370Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047621 | 37 – 106 | ALQPH…STLAE → VLPGPRGTGGSGAGVGGVPW STPAHAGAPCRQGGPSPWKP GRRDRLAEQHAGRAEWGSGS CVTATRPTGI in isoform 2. 1 PublicationAdd BLAST | 70 | |
Alternative sequenceiVSP_047622 | 37 – 80 | ALQPH…QHTQG → GAPCRQGGPSPWKPGRRDRL AEQHAGRAEWGSGSCVTATR PTGI in isoform 3. CuratedAdd BLAST | 44 | |
Alternative sequenceiVSP_047623 | 81 – 476 | Missing in isoform 3. CuratedAdd BLAST | 396 | |
Alternative sequenceiVSP_047624 | 107 – 476 | Missing in isoform 2. 1 PublicationAdd BLAST | 370 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ001902 mRNA Translation: CAA05080.1 AF000974 mRNA Translation: AAB62222.1 AF093836, AF093834, AF093835 Genomic DNA Translation: AAD03037.1 AF312032 Genomic DNA Translation: AAK21007.1 AB628086 mRNA Translation: BAK20497.1 AB628087 mRNA Translation: BAK20498.1 AK291906 mRNA Translation: BAF84595.1 AC011895 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23817.1 CH471091 Genomic DNA Translation: EAW76472.1 BC002680 mRNA Translation: AAH02680.1 BC004249 mRNA Translation: AAH04249.1 BC004999 mRNA Translation: AAH04999.1 BC021540 mRNA Translation: AAH21540.1 BC028985 mRNA Translation: AAH28985.1 L40374 mRNA Translation: AAC41740.1 Frameshift. |
CCDSi | CCDS5708.1 [Q15654-1] |
RefSeqi | NP_003293.2, NM_003302.2 [Q15654-1] |
Genome annotation databases
Ensembli | ENST00000200457.9; ENSP00000200457.4; ENSG00000087077.14 ENST00000417475.5; ENSP00000413817.1; ENSG00000087077.14 [Q15654-2] ENST00000437505.5; ENSP00000410736.1; ENSG00000087077.14 [Q15654-3] ENST00000619988.4; ENSP00000479865.1; ENSG00000087077.14 [Q15654-3] |
GeneIDi | 7205 |
KEGGi | hsa:7205 |
MANE-Selecti | ENST00000200457.9; ENSP00000200457.4; NM_003302.3; NP_003293.2 |
UCSCi | uc003uww.4, human [Q15654-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ001902 mRNA Translation: CAA05080.1 AF000974 mRNA Translation: AAB62222.1 AF093836, AF093834, AF093835 Genomic DNA Translation: AAD03037.1 AF312032 Genomic DNA Translation: AAK21007.1 AB628086 mRNA Translation: BAK20497.1 AB628087 mRNA Translation: BAK20498.1 AK291906 mRNA Translation: BAF84595.1 AC011895 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23817.1 CH471091 Genomic DNA Translation: EAW76472.1 BC002680 mRNA Translation: AAH02680.1 BC004249 mRNA Translation: AAH04249.1 BC004999 mRNA Translation: AAH04999.1 BC021540 mRNA Translation: AAH21540.1 BC028985 mRNA Translation: AAH28985.1 L40374 mRNA Translation: AAC41740.1 Frameshift. |
CCDSi | CCDS5708.1 [Q15654-1] |
RefSeqi | NP_003293.2, NM_003302.2 [Q15654-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X61 | NMR | - | A | 279-337 | [»] | |
2DLO | NMR | - | A | 329-396 | [»] | |
AlphaFoldDBi | Q15654 | |||||
SMRi | Q15654 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113056, 326 interactors |
CORUMi | Q15654 |
DIPi | DIP-34466N |
IntActi | Q15654, 221 interactors |
MINTi | Q15654 |
STRINGi | 9606.ENSP00000200457 |
PTM databases
GlyGeni | Q15654, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15654 |
PhosphoSitePlusi | Q15654 |
Genetic variation databases
BioMutai | TRIP6 |
DMDMi | 20981729 |
Proteomic databases
EPDi | Q15654 |
jPOSTi | Q15654 |
MassIVEi | Q15654 |
MaxQBi | Q15654 |
PaxDbi | Q15654 |
PeptideAtlasi | Q15654 |
PRIDEi | Q15654 |
ProteomicsDBi | 24045 24046 60696 [Q15654-1] |
Protocols and materials databases
Antibodypediai | 16676, 398 antibodies from 38 providers |
DNASUi | 7205 |
Genome annotation databases
Ensembli | ENST00000200457.9; ENSP00000200457.4; ENSG00000087077.14 ENST00000417475.5; ENSP00000413817.1; ENSG00000087077.14 [Q15654-2] ENST00000437505.5; ENSP00000410736.1; ENSG00000087077.14 [Q15654-3] ENST00000619988.4; ENSP00000479865.1; ENSG00000087077.14 [Q15654-3] |
GeneIDi | 7205 |
KEGGi | hsa:7205 |
MANE-Selecti | ENST00000200457.9; ENSP00000200457.4; NM_003302.3; NP_003293.2 |
UCSCi | uc003uww.4, human [Q15654-1] |
Organism-specific databases
CTDi | 7205 |
DisGeNETi | 7205 |
GeneCardsi | TRIP6 |
HGNCi | HGNC:12311, TRIP6 |
HPAi | ENSG00000087077, Low tissue specificity |
MIMi | 602933, gene |
neXtProti | NX_Q15654 |
OpenTargetsi | ENSG00000087077 |
PharmGKBi | PA36989 |
VEuPathDBi | HostDB:ENSG00000087077 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1701, Eukaryota |
GeneTreei | ENSGT00940000154273 |
HOGENOMi | CLU_001357_10_1_1 |
InParanoidi | Q15654 |
OMAi | SMGYPPH |
OrthoDBi | 483341at2759 |
PhylomeDBi | Q15654 |
TreeFami | TF320310 |
Enzyme and pathway databases
PathwayCommonsi | Q15654 |
SignaLinki | Q15654 |
SIGNORi | Q15654 |
Miscellaneous databases
BioGRID-ORCSi | 7205, 71 hits in 1080 CRISPR screens |
ChiTaRSi | TRIP6, human |
EvolutionaryTracei | Q15654 |
GeneWikii | TRIP6 |
GenomeRNAii | 7205 |
Pharosi | Q15654, Tbio |
PROi | PR:Q15654 |
RNActi | Q15654, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000087077, Expressed in myometrium and 232 other tissues |
ExpressionAtlasi | Q15654, baseline and differential |
Genevisiblei | Q15654, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 3 hits |
SMARTi | View protein in SMART SM00132, LIM, 3 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TRIP6_HUMAN | |
Accessioni | Q15654Primary (citable) accession number: Q15654 Secondary accession number(s): A4D2E7 Q9UNT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 15, 2002 | |
Last modified: | May 25, 2022 | |
This is version 200 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families