UniProtKB - Q15654 (TRIP6_HUMAN)
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Protein
Thyroid receptor-interacting protein 6
Gene
TRIP6
Organism
Homo sapiens (Human)
Status
Functioni
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.4 Publications
GO - Molecular functioni
- interleukin-1 receptor binding Source: UniProtKB
- kinase binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- thyroid hormone receptor binding Source: UniProtKB
GO - Biological processi
- focal adhesion assembly Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of NIK/NF-kappaB signaling Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB-KW
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
| Biological process | Cell adhesion, Transcription, Transcription regulation |
| Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
| SignaLinki | Q15654 |
| SIGNORi | Q15654 |
Names & Taxonomyi
| Protein namesi | Recommended name: Thyroid receptor-interacting protein 6Short name: TR-interacting protein 6 Short name: TRIP-6 Alternative name(s): Opa-interacting protein 1 Short name: OIP-1 Zyxin-related protein 1 Short name: ZRP-1 |
| Gene namesi | Name:TRIP6 Synonyms:OIP1 |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000087077.11 |
| HGNCi | HGNC:12311 TRIP6 |
| MIMi | 602933 gene |
| neXtProti | NX_Q15654 |
Pathology & Biotechi
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 101 | S → A: Exclusively located in nucleus. 1 Publication | 1 | |
| Mutagenesisi | 102 | S → A: Exclusively located in nucleus. 1 Publication | 1 | |
| Mutagenesisi | 474 | T → A: Reduces interaction with MAGI1. 1 Publication | 1 |
Organism-specific databases
| DisGeNETi | 7205 |
| OpenTargetsi | ENSG00000087077 |
| PharmGKBi | PA36989 |
Polymorphism and mutation databases
| BioMutai | TRIP6 |
| DMDMi | 20981729 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000075908 | 1 – 476 | Thyroid receptor-interacting protein 6Add BLAST | 476 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Modified residuei | 25 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
| Modified residuei | 25 | Omega-N-methylarginine; alternateCombined sources | 1 | |
| Modified residuei | 55 | Phosphotyrosine; by SRC2 Publications | 1 | |
| Modified residuei | 92 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 111 | Omega-N-methylarginineCombined sources | 1 | |
| Modified residuei | 142 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 179 | Omega-N-methylarginineCombined sources | 1 | |
| Modified residuei | 186 | Omega-N-methylarginineCombined sources | 1 | |
| Modified residuei | 189 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 205 | Omega-N-methylarginineCombined sources | 1 | |
| Modified residuei | 236 | Omega-N-methylarginineCombined sources | 1 | |
| Modified residuei | 238 | Omega-N-methylarginineCombined sources | 1 | |
| Modified residuei | 249 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.2 Publications
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
| EPDi | Q15654 |
| MaxQBi | Q15654 |
| PaxDbi | Q15654 |
| PeptideAtlasi | Q15654 |
| PRIDEi | Q15654 |
| ProteomicsDBi | 60696 |
PTM databases
| iPTMneti | Q15654 |
| PhosphoSitePlusi | Q15654 |
Expressioni
Tissue specificityi
Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.1 Publication
Gene expression databases
| Bgeei | ENSG00000087077 |
| CleanExi | HS_TRIP6 |
| ExpressionAtlasi | Q15654 baseline and differential |
| Genevisiblei | Q15654 HS |
Organism-specific databases
| HPAi | CAB046454 CAB046460 HPA052813 |
Interactioni
Subunit structurei
Specifically interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone (PubMed:14688263). Interacts (via the third LIM domain and C-terminus) with PTPN13 (via the second PDZ domain) (PubMed:10400701, PubMed:17591779, PubMed:19017743, PubMed:10826496). Interacts (via the second LIM domain or via the third LIM domain plus C-terminus) with PDLIM4 (via PDZ domain) (PubMed:10826496). Found in a complex with PTPN13 and PDLIM4 (By similarity). Interacts with SVIL isoform 2 (PubMed:16880273). Interacts with LPAR2 but not other LPA receptors (PubMed:14688263). Interacts with PRKAA2 (PubMed:16624523). Interacts with MAGI1 (PubMed:19017743). Interacts with SCRIB (PubMed:16137684). In case of infection, interacts with S.typhimurium protein sseI (PubMed:17095609).By similarity9 Publications
Binary interactionsi
GO - Molecular functioni
- interleukin-1 receptor binding Source: UniProtKB
- kinase binding Source: UniProtKB
- thyroid hormone receptor binding Source: UniProtKB
Protein-protein interaction databases
| BioGridi | 113056, 204 interactors |
| CORUMi | Q15654 |
| DIPi | DIP-34466N |
| IntActi | Q15654, 191 interactors |
| MINTi | Q15654 |
| STRINGi | 9606.ENSP00000200457 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Beta strandi | 280 – 282 | Combined sources | 3 | |
| Beta strandi | 288 – 290 | Combined sources | 3 | |
| Beta strandi | 296 – 300 | Combined sources | 5 | |
| Turni | 302 – 304 | Combined sources | 3 | |
| Beta strandi | 308 – 310 | Combined sources | 3 | |
| Beta strandi | 319 – 324 | Combined sources | 6 | |
| Beta strandi | 326 – 328 | Combined sources | 3 | |
| Helixi | 329 – 337 | Combined sources | 9 | |
| Turni | 340 – 342 | Combined sources | 3 | |
| Beta strandi | 351 – 353 | Combined sources | 3 | |
| Beta strandi | 356 – 358 | Combined sources | 3 | |
| Turni | 360 – 362 | Combined sources | 3 | |
| Beta strandi | 366 – 368 | Combined sources | 3 | |
| Helixi | 388 – 394 | Combined sources | 7 |
3D structure databases
| ProteinModelPortali | Q15654 |
| SMRi | Q15654 |
| ModBasei | Search... |
| MobiDBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | Q15654 |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Domaini | 279 – 316 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 38 | |
| Domaini | 339 – 398 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 60 | |
| Domaini | 399 – 467 | LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST | 69 |
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 469 – 476 | Interaction with MAGI1 and PTPN131 Publication | 8 |
Domaini
The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI.
Sequence similaritiesi
Belongs to the zyxin/ajuba family.Curated
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
| eggNOGi | KOG1701 Eukaryota ENOG410Y3GP LUCA |
| GeneTreei | ENSGT00760000119039 |
| HOVERGENi | HBG093602 |
| InParanoidi | Q15654 |
| KOi | K12792 |
| OrthoDBi | EOG091G085F |
| PhylomeDBi | Q15654 |
| TreeFami | TF320310 |
Family and domain databases
| InterProi | View protein in InterPro IPR001781 Znf_LIM |
| Pfami | View protein in Pfam PF00412 LIM, 3 hits |
| SMARTi | View protein in SMART SM00132 LIM, 3 hits |
| PROSITEi | View protein in PROSITE PS00478 LIM_DOMAIN_1, 2 hits PS50023 LIM_DOMAIN_2, 3 hits |
Sequences (3)i
Sequence statusi: Complete.
This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q15654-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSGPTWLPPK QPEPARAPQG RAIPRGTPGP PPAHGAALQP HPRVNFCPLP
60 70 80 90 100
SEQCYQAPGG PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL
110 120 130 140 150
SSTLAELNGG RGHASRRPDR QAYEPPPPPA YRTGSLKPNP ASPLPASPYG
160 170 180 190 200
GPTPASYTTA STPAGPAFPV QVKVAQPVRG CGPPRRGASQ ASGPLPGPHF
210 220 230 240 250
PLPGRGEVWG PGYRSQREPG PGAKEEAAGV SGPAGRGRGG EHGPQVPLSQ
260 270 280 290 300
PPEDELDRLT KKLVHDMNHP PSGEYFGQCG GCGEDVVGDG AGVVALDRVF
310 320 330 340 350
HVGCFVCSTC RAQLRGQHFY AVERRAYCEG CYVATLEKCA TCSQPILDRI
360 370 380 390 400
LRAMGKAYHP GCFTCVVCHR GLDGIPFTVD ATSQIHCIED FHRKFAPRCS
410 420 430 440 450
VCGGAIMPEP GQEETVRIVA LDRSFHIGCY KCEECGLLLS SEGECQGCYP
460 470
LDGHILCKAC SAWRIQELSA TVTTDC
Sequence cautioni
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 39 – 40 | Missing in AAH02680 (PubMed:15489334).Curated | 2 | |
| Sequence conflicti | 102 | S → T in AAB62222 (PubMed:10400701).Curated | 1 | |
| Sequence conflicti | 106 | E → K in AAB62222 (PubMed:10400701).Curated | 1 | |
| Sequence conflicti | 135 | S → C in CAA05080 (PubMed:9598321).Curated | 1 | |
| Sequence conflicti | 310 – 313 | CRAQ → MPGP in AAC41740 (PubMed:7776974).Curated | 4 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_062262 | 111 | R → Q1 PublicationCorresponds to variant dbSNP:rs2437100Ensembl. | 1 | |
| Natural variantiVAR_050171 | 230 | V → I1 PublicationCorresponds to variant dbSNP:rs2075756Ensembl. | 1 | |
| Natural variantiVAR_013309 | 296 | L → F1 PublicationCorresponds to variant dbSNP:rs17855370Ensembl. | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_047621 | 37 – 106 | ALQPH…STLAE → VLPGPRGTGGSGAGVGGVPW STPAHAGAPCRQGGPSPWKP GRRDRLAEQHAGRAEWGSGS CVTATRPTGI in isoform 2. 1 PublicationAdd BLAST | 70 | |
| Alternative sequenceiVSP_047622 | 37 – 80 | ALQPH…QHTQG → GAPCRQGGPSPWKPGRRDRL AEQHAGRAEWGSGSCVTATR PTGI in isoform 3. CuratedAdd BLAST | 44 | |
| Alternative sequenceiVSP_047623 | 81 – 476 | Missing in isoform 3. CuratedAdd BLAST | 396 | |
| Alternative sequenceiVSP_047624 | 107 – 476 | Missing in isoform 2. 1 PublicationAdd BLAST | 370 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ001902 mRNA Translation: CAA05080.1 AF000974 mRNA Translation: AAB62222.1 AF093836, AF093834, AF093835 Genomic DNA Translation: AAD03037.1 AF312032 Genomic DNA Translation: AAK21007.1 AB628086 mRNA Translation: BAK20497.1 AB628087 mRNA Translation: BAK20498.1 AK291906 mRNA Translation: BAF84595.1 AC011895 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23817.1 CH471091 Genomic DNA Translation: EAW76472.1 BC002680 mRNA Translation: AAH02680.1 BC004249 mRNA Translation: AAH04249.1 BC004999 mRNA Translation: AAH04999.1 BC021540 mRNA Translation: AAH21540.1 BC028985 mRNA Translation: AAH28985.1 L40374 mRNA Translation: AAC41740.1 Frameshift. |
| CCDSi | CCDS5708.1 [Q15654-1] |
| RefSeqi | NP_003293.2, NM_003302.2 [Q15654-1] |
| UniGenei | Hs.534360 |
Genome annotation databases
| Ensembli | ENST00000200457; ENSP00000200457; ENSG00000087077 [Q15654-1] ENST00000417475; ENSP00000413817; ENSG00000087077 [Q15654-2] ENST00000437505; ENSP00000410736; ENSG00000087077 [Q15654-3] ENST00000619988; ENSP00000479865; ENSG00000087077 [Q15654-3] |
| GeneIDi | 7205 |
| KEGGi | hsa:7205 |
| UCSCi | uc003uww.4 human [Q15654-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
| Entry namei | TRIP6_HUMAN | |
| Accessioni | Q15654Primary (citable) accession number: Q15654 Secondary accession number(s): A4D2E7 Q9UNT4 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
| Last sequence update: | May 15, 2002 | |
| Last modified: | July 18, 2018 | |
| This is version 175 of the entry and version 3 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families
