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UniProtKB - Q15654 (TRIP6_HUMAN)

Entry version 187 (16 Oct 2019)
Sequence version 3 (15 May 2002)
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Protein

Thyroid receptor-interacting protein 6

Gene

TRIP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15654

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15654

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroid receptor-interacting protein 6
Short name:
TR-interacting protein 6
Short name:
TRIP-6
Alternative name(s):
Opa-interacting protein 1
Short name:
OIP-1
Zyxin-related protein 1
Short name:
ZRP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIP6
Synonyms:OIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12311 TRIP6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602933 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15654

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi101S → A: Exclusively located in nucleus. 1 Publication1
Mutagenesisi102S → A: Exclusively located in nucleus. 1 Publication1
Mutagenesisi474T → A: Reduces interaction with MAGI1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		7205

Open Targets

More...OpenTargetsi		ENSG00000087077

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36989

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15654

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIP6

Domain mapping of disease mutations (DMDM)

More...DMDMi		20981729

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000759081 – 476Thyroid receptor-interacting protein 6Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei25Omega-N-methylarginine; alternateCombined sources1
Modified residuei55Phosphotyrosine; by SRC2 Publications1
Modified residuei92PhosphoserineCombined sources1
Modified residuei111Omega-N-methylarginineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei179Omega-N-methylarginineCombined sources1
Modified residuei186Omega-N-methylarginineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei205Omega-N-methylarginineCombined sources1
Modified residuei236Omega-N-methylarginineCombined sources1
Modified residuei238Omega-N-methylarginineCombined sources1
Modified residuei249PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.2 Publications

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15654

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15654

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15654

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15654

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15654

PeptideAtlas

More...PeptideAtlasi		Q15654

PRoteomics IDEntifications database

More...PRIDEi		Q15654

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		24045
24046
60696 [Q15654-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15654

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15654

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000087077 Expressed in 221 organ(s), highest expression level in thoracic mammary gland

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15654 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15654 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB046454
CAB046460
HPA052813

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Specifically interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone (PubMed:14688263).

Interacts (via the third LIM domain and C-terminus) with PTPN13 (via the second PDZ domain) (PubMed:10400701, PubMed:17591779, PubMed:19017743, PubMed:10826496).

Interacts (via the second LIM domain or via the third LIM domain plus C-terminus) with PDLIM4 (via PDZ domain) (PubMed:10826496).

Found in a complex with PTPN13 and PDLIM4 (By similarity).

Interacts with SVIL isoform 2 (PubMed:16880273).

Interacts with LPAR2 but not other LPA receptors (PubMed:14688263).

Interacts with PRKAA2 (PubMed:16624523).

Interacts with MAGI1 (PubMed:19017743).

Interacts with SCRIB (PubMed:16137684). In case of infection, interacts with S.typhimurium protein sseI (PubMed:17095609).

By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q5W1503EBI-742327,EBI-10248148
Q95HA43EBI-742327,EBI-10236795
Q9NYB93EBI-742327,EBI-743598
Q6UY14-33EBI-742327,EBI-10173507
P299726EBI-742327,EBI-745213
P542592EBI-742327,EBI-945980
P480473EBI-742327,EBI-355815
A0A0S2Z4M13EBI-742327,EBI-16429430
O151696EBI-742327,EBI-710484
Q138956EBI-742327,EBI-358049
Q8NEC56EBI-742327,EBI-744545
Q8IYX8-23EBI-742327,EBI-10181988
P264413EBI-742327,EBI-1050897
Q02930-33EBI-742327,EBI-10192698
P536733EBI-742327,EBI-7519711
O756383EBI-742327,EBI-10188927
Q9NQL93EBI-742327,EBI-9679045
Q86UW93EBI-742327,EBI-740376
Q5JVL43EBI-742327,EBI-743105
Q8N2X66EBI-742327,EBI-749333
P480233EBI-742327,EBI-495538
O435595EBI-742327,EBI-725515
A0A0S2Z4D93EBI-742327,EBI-16430771
P15976-24EBI-742327,EBI-9090198
Q9HBR33EBI-742327,EBI-10310206
P048993EBI-742327,EBI-353997
Q146873EBI-742327,EBI-372619
V9HWD03EBI-742327,EBI-10330219
P090223EBI-742327,EBI-3957603From Mus musculus.
P312694EBI-742327,EBI-742314
P174823EBI-742327,EBI-745290
A0A0C4DGM43EBI-742327,EBI-10236738
Q0VD863EBI-742327,EBI-6509505
Q997063EBI-742327,EBI-10294579
Q9H2R53EBI-742327,EBI-8645371
Q6PEX33EBI-742327,EBI-3957672
P257913EBI-742327,EBI-739696
O603363EBI-742327,EBI-947402
Q9Y3163EBI-742327,EBI-1104564
Q9H7H04EBI-742327,EBI-749353
Q8IXL73EBI-742327,EBI-8634060
O436396EBI-742327,EBI-713635
Q145113EBI-742327,EBI-2108053
Q8WWR8-23EBI-742327,EBI-10277551
O434823EBI-742327,EBI-536879
Q9BWI93EBI-742327,EBI-10300896
P096193EBI-742327,EBI-641237
Q135263EBI-742327,EBI-714158
Q3SYA93EBI-742327,EBI-10241319
Q96I343EBI-742327,EBI-710402
Q131313EBI-742327,EBI-1181405
P546463EBI-742327,EBI-1383852
P547253EBI-742327,EBI-746453
P483803EBI-742327,EBI-742557
P615863EBI-742327,EBI-446668
Q63HN8-63EBI-742327,EBI-10248548
Q8IYX73EBI-742327,EBI-3957636
Q9Y2K2-73EBI-742327,EBI-17172855
Q05CH43EBI-742327,EBI-10223741
P122363EBI-742327,EBI-356254
O757163EBI-742327,EBI-749295
O463855EBI-742327,EBI-6995105From Bos taurus.
Q9Y4C23EBI-742327,EBI-750484
Q8WW243EBI-742327,EBI-750487
Q0P5Q03EBI-742327,EBI-10226570
Q5VU623EBI-742327,EBI-10184033
O437343EBI-742327,EBI-744798
Q9UL333EBI-742327,EBI-747601
Q141343EBI-742327,EBI-702370
Q6ZVT03EBI-742327,EBI-7844656
Q997573EBI-742327,EBI-2932492
Q86UY03EBI-742327,EBI-2825190
Q062503EBI-742327,EBI-10223946
Q8N4L53EBI-742327,EBI-10265517
A2RRL93EBI-742327,EBI-10173066
A0A0S2Z5X46EBI-742327,EBI-16429014

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113056, 221 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15654

Database of interacting proteins

More...DIPi		DIP-34466N

Protein interaction database and analysis system

More...IntActi		Q15654, 205 interactors

Molecular INTeraction database

More...MINTi		Q15654

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000200457

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15654

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15654

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini279 – 316LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST38
Domaini339 – 398LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini399 – 467LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni469 – 476Interaction with MAGI1 and PTPN131 Publication8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1701 Eukaryota
ENOG410Y3GP LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154273

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15654

KEGG Orthology (KO)

More...KOi		K12792

Database of Orthologous Groups

More...OrthoDBi		483341at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15654

TreeFam database of animal gene trees

More...TreeFami		TF320310

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001781 Znf_LIM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00412 LIM, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00132 LIM, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15654-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGPTWLPPK QPEPARAPQG RAIPRGTPGP PPAHGAALQP HPRVNFCPLP 
        60         70         80         90        100
SEQCYQAPGG PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL 
       110        120        130        140        150
SSTLAELNGG RGHASRRPDR QAYEPPPPPA YRTGSLKPNP ASPLPASPYG 
       160        170        180        190        200
GPTPASYTTA STPAGPAFPV QVKVAQPVRG CGPPRRGASQ ASGPLPGPHF 
       210        220        230        240        250
PLPGRGEVWG PGYRSQREPG PGAKEEAAGV SGPAGRGRGG EHGPQVPLSQ 
       260        270        280        290        300
PPEDELDRLT KKLVHDMNHP PSGEYFGQCG GCGEDVVGDG AGVVALDRVF 
       310        320        330        340        350
HVGCFVCSTC RAQLRGQHFY AVERRAYCEG CYVATLEKCA TCSQPILDRI 
       360        370        380        390        400
LRAMGKAYHP GCFTCVVCHR GLDGIPFTVD ATSQIHCIED FHRKFAPRCS 
       410        420        430        440        450
VCGGAIMPEP GQEETVRIVA LDRSFHIGCY KCEECGLLLS SEGECQGCYP 
       460        470 
LDGHILCKAC SAWRIQELSA TVTTDC
Length:476
Mass (Da):50,288
Last modified:May 15, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BA7C747DF30A8FD
GO
Isoform 2 (identifier: Q15654-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-106: ALQPHPRVNF...IDLLSSTLAE → VLPGPRGTGG...CVTATRPTGI
     107-476: Missing.

Show »
Length:106
Mass (Da):10,602
Checksum:i33931B3C4BFC4DAB
GO
Isoform 3 (identifier: Q15654-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-80: ALQPHPRVNF...SHGVLQHTQG → GAPCRQGGPS...CVTATRPTGI
     81-476: Missing.

Show »
Length:80
Mass (Da):8,277
Checksum:iC6244DB637740E54
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZE2H7BZE2_HUMAN
Thyroid receptor-interacting protei...
TRIP6
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC41740 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39 – 40Missing in AAH02680 (PubMed:15489334).Curated2
Sequence conflicti102S → T in AAB62222 (PubMed:10400701).Curated1
Sequence conflicti106E → K in AAB62222 (PubMed:10400701).Curated1
Sequence conflicti135S → C in CAA05080 (PubMed:9598321).Curated1
Sequence conflicti310 – 313CRAQ → MPGP in AAC41740 (PubMed:7776974).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062262111R → Q1 PublicationCorresponds to variant dbSNP:rs2437100Ensembl.1
Natural variantiVAR_050171230V → I1 PublicationCorresponds to variant dbSNP:rs2075756Ensembl.1
Natural variantiVAR_013309296L → F1 PublicationCorresponds to variant dbSNP:rs17855370Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04762137 – 106ALQPH…STLAE → VLPGPRGTGGSGAGVGGVPW STPAHAGAPCRQGGPSPWKP GRRDRLAEQHAGRAEWGSGS CVTATRPTGI in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_04762237 – 80ALQPH…QHTQG → GAPCRQGGPSPWKPGRRDRL AEQHAGRAEWGSGSCVTATR PTGI in isoform 3. CuratedAdd BLAST44
Alternative sequenceiVSP_04762381 – 476Missing in isoform 3. CuratedAdd BLAST396
Alternative sequenceiVSP_047624107 – 476Missing in isoform 2. 1 PublicationAdd BLAST370

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ001902 mRNA Translation: CAA05080.1
AF000974 mRNA Translation: AAB62222.1
AF093836, AF093834, AF093835 Genomic DNA Translation: AAD03037.1
AF312032 Genomic DNA Translation: AAK21007.1
AB628086 mRNA Translation: BAK20497.1
AB628087 mRNA Translation: BAK20498.1
AK291906 mRNA Translation: BAF84595.1
AC011895 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23817.1
CH471091 Genomic DNA Translation: EAW76472.1
BC002680 mRNA Translation: AAH02680.1
BC004249 mRNA Translation: AAH04249.1
BC004999 mRNA Translation: AAH04999.1
BC021540 mRNA Translation: AAH21540.1
BC028985 mRNA Translation: AAH28985.1
L40374 mRNA Translation: AAC41740.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5708.1 [Q15654-1]

NCBI Reference Sequences

More...RefSeqi		NP_003293.2, NM_003302.2 [Q15654-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000200457; ENSP00000200457; ENSG00000087077 [Q15654-1]
ENST00000417475; ENSP00000413817; ENSG00000087077 [Q15654-2]
ENST00000437505; ENSP00000410736; ENSG00000087077 [Q15654-3]
ENST00000619988; ENSP00000479865; ENSG00000087077 [Q15654-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7205

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7205

UCSC genome browser

More...UCSCi		uc003uww.4 human [Q15654-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001902 mRNA Translation: CAA05080.1
AF000974 mRNA Translation: AAB62222.1
AF093836, AF093834, AF093835 Genomic DNA Translation: AAD03037.1
AF312032 Genomic DNA Translation: AAK21007.1
AB628086 mRNA Translation: BAK20497.1
AB628087 mRNA Translation: BAK20498.1
AK291906 mRNA Translation: BAF84595.1
AC011895 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23817.1
CH471091 Genomic DNA Translation: EAW76472.1
BC002680 mRNA Translation: AAH02680.1
BC004249 mRNA Translation: AAH04249.1
BC004999 mRNA Translation: AAH04999.1
BC021540 mRNA Translation: AAH21540.1
BC028985 mRNA Translation: AAH28985.1
L40374 mRNA Translation: AAC41740.1 Frameshift.
CCDSiCCDS5708.1 [Q15654-1]
RefSeqiNP_003293.2, NM_003302.2 [Q15654-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X61NMR-A279-337[»]
2DLONMR-A329-396[»]
SMRiQ15654
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi113056, 221 interactors
CORUMiQ15654
DIPiDIP-34466N
IntActiQ15654, 205 interactors
MINTiQ15654
STRINGi9606.ENSP00000200457

PTM databases

iPTMnetiQ15654
PhosphoSitePlusiQ15654

Polymorphism and mutation databases

BioMutaiTRIP6
DMDMi20981729

Proteomic databases

EPDiQ15654
jPOSTiQ15654
MassIVEiQ15654
MaxQBiQ15654
PaxDbiQ15654
PeptideAtlasiQ15654
PRIDEiQ15654
ProteomicsDBi24045
24046
60696 [Q15654-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		7205

Genome annotation databases

EnsembliENST00000200457; ENSP00000200457; ENSG00000087077 [Q15654-1]
ENST00000417475; ENSP00000413817; ENSG00000087077 [Q15654-2]
ENST00000437505; ENSP00000410736; ENSG00000087077 [Q15654-3]
ENST00000619988; ENSP00000479865; ENSG00000087077 [Q15654-3]
GeneIDi7205
KEGGihsa:7205
UCSCiuc003uww.4 human [Q15654-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7205
DisGeNETi7205

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIP6
HGNCiHGNC:12311 TRIP6
HPAiCAB046454
CAB046460
HPA052813
MIMi602933 gene
neXtProtiNX_Q15654
OpenTargetsiENSG00000087077
PharmGKBiPA36989

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1701 Eukaryota
ENOG410Y3GP LUCA
GeneTreeiENSGT00940000154273
InParanoidiQ15654
KOiK12792
OrthoDBi483341at2759
PhylomeDBiQ15654
TreeFamiTF320310

Enzyme and pathway databases

SignaLinkiQ15654
SIGNORiQ15654

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIP6 human
EvolutionaryTraceiQ15654

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRIP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7205
PharosiQ15654

Protein Ontology

More...PROi		PR:Q15654

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000087077 Expressed in 221 organ(s), highest expression level in thoracic mammary gland
ExpressionAtlasiQ15654 baseline and differential
GenevisibleiQ15654 HS

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIP6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15654
Secondary accession number(s): A4D2E7
, F2ZC07, F2ZC08, O15170, O15275, Q9BTB2, Q9BUE5, Q9BXP3, Q9UNT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 15, 2002
Last modified: October 16, 2019
This is version 187 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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