UniProtKB - Q15652 (JHD2C_HUMAN)
Protein
Probable JmjC domain-containing histone demethylation protein 2C
Gene
JMJD1C
Organism
Homo sapiens (Human)
Status
Functioni
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).By similarity
Cofactori
Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 2336 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 2338 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 2466 | Iron; catalyticPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1846 – 1871 | C6-typeSequence analysisAdd BLAST | 26 |
GO - Molecular functioni
- chromatin DNA binding Source: GO_Central
- dioxygenase activity Source: UniProtKB-KW
- histone demethylase activity (H3-K9 specific) Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- thyroid hormone receptor binding Source: UniProtKB
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- blood coagulation Source: Reactome
- histone H3-K9 demethylation Source: GO_Central
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Chromatin regulator, Dioxygenase, Oxidoreductase |
Biological process | Transcription, Transcription regulation |
Ligand | Iron, Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000171988-MONOMER |
PathwayCommonsi | Q15652 |
Reactomei | R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: Probable JmjC domain-containing histone demethylation protein 2C (EC:1.14.11.-)Alternative name(s): Jumonji domain-containing protein 1C Thyroid receptor-interacting protein 8 Short name: TR-interacting protein 8 Short name: TRIP-8 |
Gene namesi | Name:JMJD1C Synonyms:JHDM2C, KIAA1380, TRIP8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12313, JMJD1C |
MIMi | 604503, gene |
neXtProti | NX_Q15652 |
VEuPathDBi | HostDB:ENSG00000171988.17 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- histone deacetylase complex Source: GO_Central
- nucleoplasm Source: Reactome
Other locations
- chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 221037 |
MalaCardsi | JMJD1C |
OpenTargetsi | ENSG00000171988 |
Orphaneti | 567, 22q11.2 deletion syndrome 91352, Germinoma of the central nervous system |
PharmGKBi | PA128394767 |
Miscellaneous databases
Pharosi | Q15652, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3792271 |
Genetic variation databases
BioMutai | JMJD1C |
DMDMi | 85541650 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084284 | 1 – 2540 | Probable JmjC domain-containing histone demethylation protein 2CAdd BLAST | 2540 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 317 | PhosphoserineCombined sources | 1 | |
Modified residuei | 320 | PhosphoserineBy similarity | 1 | |
Modified residuei | 373 | PhosphoserineCombined sources | 1 | |
Modified residuei | 376 | PhosphoserineCombined sources | 1 | |
Modified residuei | 475 | PhosphoserineBy similarity | 1 | |
Modified residuei | 501 | PhosphoserineCombined sources | 1 | |
Modified residuei | 505 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 601 | PhosphoserineCombined sources | 1 | |
Modified residuei | 617 | PhosphoserineCombined sources | 1 | |
Modified residuei | 638 | PhosphoserineCombined sources | 1 | |
Modified residuei | 639 | PhosphoserineCombined sources | 1 | |
Modified residuei | 641 | PhosphoserineCombined sources | 1 | |
Modified residuei | 652 | PhosphoserineCombined sources | 1 | |
Modified residuei | 943 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1989 | PhosphoserineCombined sources | 1 | |
Cross-linki | 2132 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2136 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q15652 |
jPOSTi | Q15652 |
MassIVEi | Q15652 |
MaxQBi | Q15652 |
PaxDbi | Q15652 |
PeptideAtlasi | Q15652 |
PRIDEi | Q15652 |
ProteomicsDBi | 60691 [Q15652-1] 60692 [Q15652-2] 60693 [Q15652-3] |
PTM databases
GlyGeni | Q15652, 3 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q15652 |
PhosphoSitePlusi | Q15652 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171988, Expressed in intestine and 240 other tissues |
ExpressionAtlasi | Q15652, baseline and differential |
Genevisiblei | Q15652, HS |
Organism-specific databases
HPAi | ENSG00000171988, Low tissue specificity |
Interactioni
Subunit structurei
Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.
1 PublicationBinary interactionsi
Q15652
With | #Exp. | IntAct |
---|---|---|
AR [P10275] | 2 | EBI-1224969,EBI-608057 |
GO - Molecular functioni
- thyroid hormone receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 128677, 42 interactors |
DIPi | DIP-38114N |
IntActi | Q15652, 16 interactors |
MINTi | Q15652 |
STRINGi | 9606.ENSP00000382204 |
Chemistry databases
BindingDBi | Q15652 |
Miscellaneous databases
RNActi | Q15652, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q15652 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2274 – 2498 | JmjCPROSITE-ProRule annotationAdd BLAST | 225 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 2066 – 2070 | LXXLL motif | 5 |
Domaini
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity
Sequence similaritiesi
Belongs to the JHDM2 histone demethylase family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1846 – 1871 | C6-typeSequence analysisAdd BLAST | 26 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1356, Eukaryota |
GeneTreei | ENSGT00940000158210 |
HOGENOMi | CLU_228251_0_0_1 |
InParanoidi | Q15652 |
OMAi | FMSSLNV |
OrthoDBi | 1185631at2759 |
PhylomeDBi | Q15652 |
TreeFami | TF324723 |
Family and domain databases
InterProi | View protein in InterPro IPR003347, JmjC_dom |
Pfami | View protein in Pfam PF02373, JmjC, 1 hit |
SMARTi | View protein in SMART SM00558, JmjC, 1 hit |
PROSITEi | View protein in PROSITE PS51184, JMJC, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q15652-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS
60 70 80 90 100
RNPDLAVYVE FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG
110 120 130 140 150
SKSKQIQWPA LTFKPLVERN IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD
160 170 180 190 200
DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE IFMQGPYSLN GYRVRVYRQD
210 220 230 240 250
SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM TFLDDVVHSL
260 270 280 290 300
LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT
310 320 330 340 350
HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN
360 370 380 390 400
KRRKPEEDEK KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE
410 420 430 440 450
LKNKNTSKIN GEEGKPHNNE KAGEETLKNS QPPWDQIQED KKHEEAEKRK
460 470 480 490 500
SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP QECNMDKTHT MELLPKEKFV
510 520 530 540 550
SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN VSDSKHSIAN
560 570 580 590 600
AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI
610 620 630 640 650
SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT
660 670 680 690 700
HSPDSVKSKA TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK
710 720 730 740 750
SPLIIDKNEH FTVYRDPALI GSETGANHIS PFLSQHPFPL HSSSHRTCLN
760 770 780 790 800
PGTHHPALTP APHLLAGSSS QTPLPTINTH PLTSGPHHAV HHPHLLPTVL
810 820 830 840 850
PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ SPHLLGQAHP
860 870 880 890 900
SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS
910 920 930 940 950
PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL
960 970 980 990 1000
VDHHKEELER KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV
1010 1020 1030 1040 1050
LNQLQRPPQE TGERLNKYKE EHRRILQESI DVAPFTTKIK GLEGERENYS
1060 1070 1080 1090 1100
RVASSSSSPK SHIIKQDMDV ERSVSDLYKM KHSVPQSLPQ SNYFTTLSNS
1110 1120 1130 1140 1150
VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI TSLSKPPPLI
1160 1170 1180 1190 1200
KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM
1210 1220 1230 1240 1250
PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP
1260 1270 1280 1290 1300
PTLIPEPKDS QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA
1310 1320 1330 1340 1350
AMASVIVRPS SSTKTDSMPA MQLASKDRVS ERSSAGAHKT DCLKLAEAGE
1360 1370 1380 1390 1400
TGRIILPNVN SDSVHTKSEK NFQAVSQGSV PSSVMSAVNT MCNTKTDVIT
1410 1420 1430 1440 1450
SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ PVAQKQECKV
1460 1470 1480 1490 1500
STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS
1510 1520 1530 1540 1550
ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL
1560 1570 1580 1590 1600
KKAWLTRHSE EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS
1610 1620 1630 1640 1650
KIIVDKYVKD DKVNRRKAKR TYESGSESGD SDESESKSEQ RTKRQPKPTY
1660 1670 1680 1690 1700
KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE RSKLKLQSNS NTGIPRSVLK
1710 1720 1730 1740 1750
DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK KGEEPAHSPV
1760 1770 1780 1790 1800
FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE
1810 1820 1830 1840 1850
TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE
1860 1870 1880 1890 1900
ATLFNIHWVC QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK
1910 1920 1930 1940 1950
HLMPTQIIPG SVLTDLLDAM HTLREKYGIK SHCHCTNKQN LQVGNFPTMN
1960 1970 1980 1990 2000
GVSQVLQNVL NHSNKISLCM PESQQQNTPP KSEKNGGSSP ESDVGTDNKL
2010 2020 2030 2040 2050
TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER EQDNSESPNG
2060 2070 2080 2090 2100
RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK
2110 2120 2130 2140 2150
SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN
2160 2170 2180 2190 2200
NKLYSDIPHS WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK
2210 2220 2230 2240 2250
MNISLWKAES ISLDFGDHQA DLLNCKDSII SNANVKEFWD GFEEVSKRQK
2260 2270 2280 2290 2300
NKSGETVVLK LKDWPSGEDF KTMMPARYED LLKSLPLPEY CNPEGKFNLA
2310 2320 2330 2340 2350
SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS DVVNILVYVG
2360 2370 2380 2390 2400
IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD
2410 2420 2430 2440 2450
KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL
2460 2470 2480 2490 2500
IQFLGDAIVL PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL
2510 2520 2530 2540
KEEINYDDKL QVKNILYHAV KEMVRALKIH EDEVEDMEEN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2PNZ9 | A0A1W2PNZ9_HUMAN | Probable JmjC domain-containing his... | JMJD1C | 2,358 | Annotation score: | ||
H7BXU7 | H7BXU7_HUMAN | Probable JmjC domain-containing his... | JMJD1C | 956 | Annotation score: |
Sequence cautioni
The sequence AAC41741 differs from that shown. Reason: Frameshift.Curated
The sequence CAD97921 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 488 | T → A in CAD97921 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 779 | T → A in CAD97921 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 783 | T → P in CAD97921 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 2093 | S → A in AAC41741 (PubMed:7776974).Curated | 1 | |
Sequence conflicti | 2148 | Missing in BAA92618 (PubMed:10718198).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049654 | 272 | A → T. Corresponds to variant dbSNP:rs34798625EnsemblClinVar. | 1 | |
Natural variantiVAR_049655 | 394 | E → D. Corresponds to variant dbSNP:rs35380596Ensembl. | 1 | |
Natural variantiVAR_049656 | 464 | S → T1 PublicationCorresponds to variant dbSNP:rs10761725Ensembl. | 1 | |
Natural variantiVAR_061277 | 591 | M → V. Corresponds to variant dbSNP:rs41274072EnsemblClinVar. | 1 | |
Natural variantiVAR_049657 | 1393 | N → Y. Corresponds to variant dbSNP:rs9703886Ensembl. | 1 | |
Natural variantiVAR_049658 | 2400 | D → E. Corresponds to variant dbSNP:rs34491125EnsemblClinVar. | 1 | |
Natural variantiVAR_049659 | 2535 | E → D1 PublicationCorresponds to variant dbSNP:rs1935Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018303 | 1 – 219 | Missing in isoform 2. 1 PublicationAdd BLAST | 219 | |
Alternative sequenceiVSP_043909 | 1 – 182 | Missing in isoform 3. 1 PublicationAdd BLAST | 182 | |
Alternative sequenceiVSP_018304 | 1692 – 1699 | TGIPRSVL → SCHLVKTE in isoform 2. 1 Publication | 8 | |
Alternative sequenceiVSP_018305 | 1700 – 2540 | Missing in isoform 2. 1 PublicationAdd BLAST | 841 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF068222 mRNA Translation: ABK64187.1 BX537954 mRNA Translation: CAD97921.1 Frameshift. AC022022 Genomic DNA No translation available. AL590502 Genomic DNA No translation available. AL607128 Genomic DNA No translation available. AL713895 Genomic DNA No translation available. AK027280 mRNA No translation available. AL831917 mRNA Translation: CAD38578.1 AB037801 mRNA Translation: BAA92618.1 L40411 mRNA Translation: AAC41741.1 Frameshift. |
CCDSi | CCDS41532.1 [Q15652-1] CCDS60538.1 [Q15652-3] |
RefSeqi | NP_001269877.1, NM_001282948.1 [Q15652-3] NP_001305082.1, NM_001318153.1 NP_001305083.1, NM_001318154.1 [Q15652-3] NP_001309181.1, NM_001322252.1 NP_001309183.1, NM_001322254.1 NP_001309187.1, NM_001322258.1 NP_116165.1, NM_032776.2 [Q15652-1] XP_016871386.1, XM_017015897.1 [Q15652-3] XP_016871387.1, XM_017015898.1 [Q15652-3] |
Genome annotation databases
Ensembli | ENST00000399262; ENSP00000382204; ENSG00000171988 [Q15652-1] ENST00000542921; ENSP00000444682; ENSG00000171988 [Q15652-3] |
GeneIDi | 221037 |
KEGGi | hsa:221037 |
UCSCi | uc001jmn.5, human [Q15652-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF068222 mRNA Translation: ABK64187.1 BX537954 mRNA Translation: CAD97921.1 Frameshift. AC022022 Genomic DNA No translation available. AL590502 Genomic DNA No translation available. AL607128 Genomic DNA No translation available. AL713895 Genomic DNA No translation available. AK027280 mRNA No translation available. AL831917 mRNA Translation: CAD38578.1 AB037801 mRNA Translation: BAA92618.1 L40411 mRNA Translation: AAC41741.1 Frameshift. |
CCDSi | CCDS41532.1 [Q15652-1] CCDS60538.1 [Q15652-3] |
RefSeqi | NP_001269877.1, NM_001282948.1 [Q15652-3] NP_001305082.1, NM_001318153.1 NP_001305083.1, NM_001318154.1 [Q15652-3] NP_001309181.1, NM_001322252.1 NP_001309183.1, NM_001322254.1 NP_001309187.1, NM_001322258.1 NP_116165.1, NM_032776.2 [Q15652-1] XP_016871386.1, XM_017015897.1 [Q15652-3] XP_016871387.1, XM_017015898.1 [Q15652-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2YPD | X-ray | 2.10 | A/B | 2157-2540 | [»] | |
5FZO | X-ray | 1.84 | A/B | 2157-2500 | [»] | |
SMRi | Q15652 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 128677, 42 interactors |
DIPi | DIP-38114N |
IntActi | Q15652, 16 interactors |
MINTi | Q15652 |
STRINGi | 9606.ENSP00000382204 |
Chemistry databases
BindingDBi | Q15652 |
ChEMBLi | CHEMBL3792271 |
PTM databases
GlyGeni | Q15652, 3 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q15652 |
PhosphoSitePlusi | Q15652 |
Genetic variation databases
BioMutai | JMJD1C |
DMDMi | 85541650 |
Proteomic databases
EPDi | Q15652 |
jPOSTi | Q15652 |
MassIVEi | Q15652 |
MaxQBi | Q15652 |
PaxDbi | Q15652 |
PeptideAtlasi | Q15652 |
PRIDEi | Q15652 |
ProteomicsDBi | 60691 [Q15652-1] 60692 [Q15652-2] 60693 [Q15652-3] |
Protocols and materials databases
Antibodypediai | 28318, 133 antibodies |
Genome annotation databases
Ensembli | ENST00000399262; ENSP00000382204; ENSG00000171988 [Q15652-1] ENST00000542921; ENSP00000444682; ENSG00000171988 [Q15652-3] |
GeneIDi | 221037 |
KEGGi | hsa:221037 |
UCSCi | uc001jmn.5, human [Q15652-1] |
Organism-specific databases
CTDi | 221037 |
DisGeNETi | 221037 |
GeneCardsi | JMJD1C |
HGNCi | HGNC:12313, JMJD1C |
HPAi | ENSG00000171988, Low tissue specificity |
MalaCardsi | JMJD1C |
MIMi | 604503, gene |
neXtProti | NX_Q15652 |
OpenTargetsi | ENSG00000171988 |
Orphaneti | 567, 22q11.2 deletion syndrome 91352, Germinoma of the central nervous system |
PharmGKBi | PA128394767 |
VEuPathDBi | HostDB:ENSG00000171988.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1356, Eukaryota |
GeneTreei | ENSGT00940000158210 |
HOGENOMi | CLU_228251_0_0_1 |
InParanoidi | Q15652 |
OMAi | FMSSLNV |
OrthoDBi | 1185631at2759 |
PhylomeDBi | Q15652 |
TreeFami | TF324723 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000171988-MONOMER |
PathwayCommonsi | Q15652 |
Reactomei | R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
Miscellaneous databases
BioGRID-ORCSi | 221037, 12 hits in 998 CRISPR screens |
ChiTaRSi | JMJD1C, human |
GenomeRNAii | 221037 |
Pharosi | Q15652, Tbio |
PROi | PR:Q15652 |
RNActi | Q15652, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171988, Expressed in intestine and 240 other tissues |
ExpressionAtlasi | Q15652, baseline and differential |
Genevisiblei | Q15652, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003347, JmjC_dom |
Pfami | View protein in Pfam PF02373, JmjC, 1 hit |
SMARTi | View protein in SMART SM00558, JmjC, 1 hit |
PROSITEi | View protein in PROSITE PS51184, JMJC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | JHD2C_HUMAN | |
Accessioni | Q15652Primary (citable) accession number: Q15652 Secondary accession number(s): A0T124 Q9P2G7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 10, 2006 | |
Last modified: | April 7, 2021 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families