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Protein

Probable JmjC domain-containing histone demethylation protein 2C

Gene

JMJD1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2336Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2338Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2466Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1846 – 1871C6-typeSequence analysisAdd BLAST26

GO - Molecular functioni

  • chromatin DNA binding Source: GO_Central
  • dioxygenase activity Source: UniProtKB-KW
  • histone demethylase activity (H3-K9 specific) Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • thyroid hormone receptor binding Source: UniProtKB
  • transcription regulatory region sequence-specific DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Probable JmjC domain-containing histone demethylation protein 2C (EC:1.14.11.-)
Alternative name(s):
Jumonji domain-containing protein 1C
Thyroid receptor-interacting protein 8
Short name:
TR-interacting protein 8
Short name:
TRIP-8
Gene namesi
Name:JMJD1C
Synonyms:JHDM2C, KIAA1380, TRIP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000171988.17
HGNCiHGNC:12313 JMJD1C
MIMi604503 gene
neXtProtiNX_Q15652

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi221037
MalaCardsiJMJD1C
OpenTargetsiENSG00000171988
Orphaneti567 22q11.2 deletion syndrome
91352 Germinoma of the central nervous system
PharmGKBiPA128394767

Chemistry databases

ChEMBLiCHEMBL3792271

Polymorphism and mutation databases

BioMutaiJMJD1C
DMDMi85541650

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000842841 – 2540Probable JmjC domain-containing histone demethylation protein 2CAdd BLAST2540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei317PhosphoserineCombined sources1
Modified residuei320PhosphoserineBy similarity1
Modified residuei373PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei475PhosphoserineBy similarity1
Modified residuei501PhosphoserineCombined sources1
Modified residuei505PhosphothreonineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei943PhosphoserineCombined sources1
Modified residuei1989PhosphoserineCombined sources1
Cross-linki2132Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15652
MaxQBiQ15652
PaxDbiQ15652
PeptideAtlasiQ15652
PRIDEiQ15652
ProteomicsDBi60691
60692 [Q15652-2]
60693 [Q15652-3]

PTM databases

iPTMnetiQ15652
PhosphoSitePlusiQ15652

Expressioni

Gene expression databases

BgeeiENSG00000171988 Expressed in 229 organ(s), highest expression level in intestine
CleanExiHS_JMJD1C
ExpressionAtlasiQ15652 baseline and differential
GenevisibleiQ15652 HS

Organism-specific databases

HPAiHPA056175
HPA066195

Interactioni

Subunit structurei

Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102752EBI-1224969,EBI-608057

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128677, 17 interactors
DIPiDIP-38114N
IntActiQ15652, 15 interactors
MINTiQ15652
STRINGi9606.ENSP00000382204

Chemistry databases

BindingDBiQ15652

Structurei

Secondary structure

12540
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15652
SMRiQ15652
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2274 – 2498JmjCPROSITE-ProRule annotationAdd BLAST225

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2066 – 2070LXXLL motif5

Domaini

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the JHDM2 histone demethylase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1846 – 1871C6-typeSequence analysisAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
GeneTreeiENSGT00530000063039
HOVERGENiHBG079631
InParanoidiQ15652
KOiK11449
OMAiEMWKSNN
OrthoDBiEOG091G00RB
PhylomeDBiQ15652
TreeFamiTF324723

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15652-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS
60 70 80 90 100
RNPDLAVYVE FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG
110 120 130 140 150
SKSKQIQWPA LTFKPLVERN IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD
160 170 180 190 200
DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE IFMQGPYSLN GYRVRVYRQD
210 220 230 240 250
SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM TFLDDVVHSL
260 270 280 290 300
LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT
310 320 330 340 350
HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN
360 370 380 390 400
KRRKPEEDEK KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE
410 420 430 440 450
LKNKNTSKIN GEEGKPHNNE KAGEETLKNS QPPWDQIQED KKHEEAEKRK
460 470 480 490 500
SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP QECNMDKTHT MELLPKEKFV
510 520 530 540 550
SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN VSDSKHSIAN
560 570 580 590 600
AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI
610 620 630 640 650
SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT
660 670 680 690 700
HSPDSVKSKA TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK
710 720 730 740 750
SPLIIDKNEH FTVYRDPALI GSETGANHIS PFLSQHPFPL HSSSHRTCLN
760 770 780 790 800
PGTHHPALTP APHLLAGSSS QTPLPTINTH PLTSGPHHAV HHPHLLPTVL
810 820 830 840 850
PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ SPHLLGQAHP
860 870 880 890 900
SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS
910 920 930 940 950
PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL
960 970 980 990 1000
VDHHKEELER KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV
1010 1020 1030 1040 1050
LNQLQRPPQE TGERLNKYKE EHRRILQESI DVAPFTTKIK GLEGERENYS
1060 1070 1080 1090 1100
RVASSSSSPK SHIIKQDMDV ERSVSDLYKM KHSVPQSLPQ SNYFTTLSNS
1110 1120 1130 1140 1150
VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI TSLSKPPPLI
1160 1170 1180 1190 1200
KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM
1210 1220 1230 1240 1250
PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP
1260 1270 1280 1290 1300
PTLIPEPKDS QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA
1310 1320 1330 1340 1350
AMASVIVRPS SSTKTDSMPA MQLASKDRVS ERSSAGAHKT DCLKLAEAGE
1360 1370 1380 1390 1400
TGRIILPNVN SDSVHTKSEK NFQAVSQGSV PSSVMSAVNT MCNTKTDVIT
1410 1420 1430 1440 1450
SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ PVAQKQECKV
1460 1470 1480 1490 1500
STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS
1510 1520 1530 1540 1550
ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL
1560 1570 1580 1590 1600
KKAWLTRHSE EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS
1610 1620 1630 1640 1650
KIIVDKYVKD DKVNRRKAKR TYESGSESGD SDESESKSEQ RTKRQPKPTY
1660 1670 1680 1690 1700
KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE RSKLKLQSNS NTGIPRSVLK
1710 1720 1730 1740 1750
DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK KGEEPAHSPV
1760 1770 1780 1790 1800
FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE
1810 1820 1830 1840 1850
TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE
1860 1870 1880 1890 1900
ATLFNIHWVC QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK
1910 1920 1930 1940 1950
HLMPTQIIPG SVLTDLLDAM HTLREKYGIK SHCHCTNKQN LQVGNFPTMN
1960 1970 1980 1990 2000
GVSQVLQNVL NHSNKISLCM PESQQQNTPP KSEKNGGSSP ESDVGTDNKL
2010 2020 2030 2040 2050
TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER EQDNSESPNG
2060 2070 2080 2090 2100
RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK
2110 2120 2130 2140 2150
SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN
2160 2170 2180 2190 2200
NKLYSDIPHS WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK
2210 2220 2230 2240 2250
MNISLWKAES ISLDFGDHQA DLLNCKDSII SNANVKEFWD GFEEVSKRQK
2260 2270 2280 2290 2300
NKSGETVVLK LKDWPSGEDF KTMMPARYED LLKSLPLPEY CNPEGKFNLA
2310 2320 2330 2340 2350
SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS DVVNILVYVG
2360 2370 2380 2390 2400
IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD
2410 2420 2430 2440 2450
KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL
2460 2470 2480 2490 2500
IQFLGDAIVL PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL
2510 2520 2530 2540
KEEINYDDKL QVKNILYHAV KEMVRALKIH EDEVEDMEEN
Length:2,540
Mass (Da):284,525
Last modified:January 10, 2006 - v2
Checksum:i8B1727414D6B677F
GO
Isoform 2 (identifier: Q15652-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.
     1692-1699: TGIPRSVL → SCHLVKTE
     1700-2540: Missing.

Note: No experimental confirmation available.
Show »
Length:1,480
Mass (Da):163,133
Checksum:i72DB291B3FAB25B7
GO
Isoform 3 (identifier: Q15652-3) [UniParc]FASTAAdd to basket
Also known as: s-JMJD1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Note: May function as a tumor suppressor, reduced expression in breast cancer tumors.
Show »
Length:2,358
Mass (Da):263,157
Checksum:i6005F440A38FC096
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXU7H7BXU7_HUMAN
Probable JmjC domain-containing his...
JMJD1C
956Annotation score:
A0A1W2PNZ9A0A1W2PNZ9_HUMAN
Probable JmjC domain-containing his...
JMJD1C
2,358Annotation score:

Sequence cautioni

The sequence AAC41741 differs from that shown. Reason: Frameshift at position 2171.Curated
The sequence CAD97921 differs from that shown. Reason: Frameshift at position 1697.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti488T → A in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti779T → A in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti783T → P in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti2093S → A in AAC41741 (PubMed:7776974).Curated1
Sequence conflicti2148Missing in BAA92618 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049654272A → T. Corresponds to variant dbSNP:rs34798625EnsemblClinVar.1
Natural variantiVAR_049655394E → D. Corresponds to variant dbSNP:rs35380596Ensembl.1
Natural variantiVAR_049656464S → T1 PublicationCorresponds to variant dbSNP:rs10761725Ensembl.1
Natural variantiVAR_061277591M → V. Corresponds to variant dbSNP:rs41274072EnsemblClinVar.1
Natural variantiVAR_0496571393N → Y. Corresponds to variant dbSNP:rs9703886Ensembl.1
Natural variantiVAR_0496582400D → E. Corresponds to variant dbSNP:rs34491125EnsemblClinVar.1
Natural variantiVAR_0496592535E → D1 PublicationCorresponds to variant dbSNP:rs1935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183031 – 219Missing in isoform 2. 1 PublicationAdd BLAST219
Alternative sequenceiVSP_0439091 – 182Missing in isoform 3. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_0183041692 – 1699TGIPRSVL → SCHLVKTE in isoform 2. 1 Publication8
Alternative sequenceiVSP_0183051700 – 2540Missing in isoform 2. 1 PublicationAdd BLAST841

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF068222 mRNA Translation: ABK64187.1
BX537954 mRNA Translation: CAD97921.1 Frameshift.
AC022022 Genomic DNA No translation available.
AL590502 Genomic DNA No translation available.
AL607128 Genomic DNA No translation available.
AL713895 Genomic DNA No translation available.
AK027280 mRNA No translation available.
AL831917 mRNA Translation: CAD38578.1
AB037801 mRNA Translation: BAA92618.1
L40411 mRNA Translation: AAC41741.1 Frameshift.
CCDSiCCDS41532.1 [Q15652-1]
CCDS60538.1 [Q15652-3]
RefSeqiNP_001269877.1, NM_001282948.1 [Q15652-3]
NP_001305082.1, NM_001318153.1
NP_001305083.1, NM_001318154.1 [Q15652-3]
NP_001309181.1, NM_001322252.1
NP_001309183.1, NM_001322254.1
NP_001309187.1, NM_001322258.1
NP_116165.1, NM_032776.2 [Q15652-1]
XP_016871386.1, XM_017015897.1 [Q15652-3]
XP_016871387.1, XM_017015898.1 [Q15652-3]
UniGeneiHs.413416

Genome annotation databases

EnsembliENST00000399262; ENSP00000382204; ENSG00000171988 [Q15652-1]
ENST00000542921; ENSP00000444682; ENSG00000171988 [Q15652-3]
GeneIDi221037
KEGGihsa:221037
UCSCiuc001jmn.5 human [Q15652-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF068222 mRNA Translation: ABK64187.1
BX537954 mRNA Translation: CAD97921.1 Frameshift.
AC022022 Genomic DNA No translation available.
AL590502 Genomic DNA No translation available.
AL607128 Genomic DNA No translation available.
AL713895 Genomic DNA No translation available.
AK027280 mRNA No translation available.
AL831917 mRNA Translation: CAD38578.1
AB037801 mRNA Translation: BAA92618.1
L40411 mRNA Translation: AAC41741.1 Frameshift.
CCDSiCCDS41532.1 [Q15652-1]
CCDS60538.1 [Q15652-3]
RefSeqiNP_001269877.1, NM_001282948.1 [Q15652-3]
NP_001305082.1, NM_001318153.1
NP_001305083.1, NM_001318154.1 [Q15652-3]
NP_001309181.1, NM_001322252.1
NP_001309183.1, NM_001322254.1
NP_001309187.1, NM_001322258.1
NP_116165.1, NM_032776.2 [Q15652-1]
XP_016871386.1, XM_017015897.1 [Q15652-3]
XP_016871387.1, XM_017015898.1 [Q15652-3]
UniGeneiHs.413416

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPDX-ray2.10A/B2157-2540[»]
5FZOX-ray1.84A/B2157-2500[»]
ProteinModelPortaliQ15652
SMRiQ15652
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128677, 17 interactors
DIPiDIP-38114N
IntActiQ15652, 15 interactors
MINTiQ15652
STRINGi9606.ENSP00000382204

Chemistry databases

BindingDBiQ15652
ChEMBLiCHEMBL3792271

PTM databases

iPTMnetiQ15652
PhosphoSitePlusiQ15652

Polymorphism and mutation databases

BioMutaiJMJD1C
DMDMi85541650

Proteomic databases

EPDiQ15652
MaxQBiQ15652
PaxDbiQ15652
PeptideAtlasiQ15652
PRIDEiQ15652
ProteomicsDBi60691
60692 [Q15652-2]
60693 [Q15652-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399262; ENSP00000382204; ENSG00000171988 [Q15652-1]
ENST00000542921; ENSP00000444682; ENSG00000171988 [Q15652-3]
GeneIDi221037
KEGGihsa:221037
UCSCiuc001jmn.5 human [Q15652-1]

Organism-specific databases

CTDi221037
DisGeNETi221037
EuPathDBiHostDB:ENSG00000171988.17
GeneCardsiJMJD1C
H-InvDBiHIX0008863
HGNCiHGNC:12313 JMJD1C
HPAiHPA056175
HPA066195
MalaCardsiJMJD1C
MIMi604503 gene
neXtProtiNX_Q15652
OpenTargetsiENSG00000171988
Orphaneti567 22q11.2 deletion syndrome
91352 Germinoma of the central nervous system
PharmGKBiPA128394767
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
GeneTreeiENSGT00530000063039
HOVERGENiHBG079631
InParanoidiQ15652
KOiK11449
OMAiEMWKSNN
OrthoDBiEOG091G00RB
PhylomeDBiQ15652
TreeFamiTF324723

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRSiJMJD1C human
GenomeRNAii221037
PROiPR:Q15652
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171988 Expressed in 229 organ(s), highest expression level in intestine
CleanExiHS_JMJD1C
ExpressionAtlasiQ15652 baseline and differential
GenevisibleiQ15652 HS

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJHD2C_HUMAN
AccessioniPrimary (citable) accession number: Q15652
Secondary accession number(s): A0T124
, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2006
Last modified: November 7, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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