Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q15652 (JHD2C_HUMAN)

(max 400 entries)x

Your basket is currently empty. i

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable JmjC domain-containing histone demethylation protein 2C

Gene

JMJD1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2336Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2338Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2466Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1846 – 1871C6-typeSequence analysisAdd BLAST26

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Probable JmjC domain-containing histone demethylation protein 2C (EC:1.14.11.-)
Alternative name(s):
Jumonji domain-containing protein 1C
Thyroid receptor-interacting protein 8
Short name:
TR-interacting protein 8
Short name:
TRIP-8
Gene namesi
Name:JMJD1C
Synonyms:JHDM2C, KIAA1380, TRIP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000171988.17
HGNCiHGNC:12313 JMJD1C
MIMi604503 gene
neXtProtiNX_Q15652

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi221037
MalaCardsiJMJD1C
OpenTargetsiENSG00000171988
Orphaneti91352 Germinoma of the central nervous system
PharmGKBiPA128394767

Chemistry databases

ChEMBLiCHEMBL3792271

Polymorphism and mutation databases

BioMutaiJMJD1C
DMDMi85541650

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000842841 – 2540Probable JmjC domain-containing histone demethylation protein 2CAdd BLAST2540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei317PhosphoserineCombined sources1
Modified residuei320PhosphoserineBy similarity1
Modified residuei373PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei475PhosphoserineBy similarity1
Modified residuei501PhosphoserineCombined sources1
Modified residuei505PhosphothreonineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei943PhosphoserineCombined sources1
Modified residuei1989PhosphoserineCombined sources1
Cross-linki2132Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15652
MaxQBiQ15652
PaxDbiQ15652
PeptideAtlasiQ15652
PRIDEiQ15652
ProteomicsDBi60691
60692 [Q15652-2]
60693 [Q15652-3]

PTM databases

iPTMnetiQ15652
PhosphoSitePlusiQ15652

Expressioni

Gene expression databases

BgeeiENSG00000171988
CleanExiHS_JMJD1C
ExpressionAtlasiQ15652 baseline and differential
GenevisibleiQ15652 HS

Organism-specific databases

HPAiHPA056175
HPA066195

Interactioni

Subunit structurei

Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102752EBI-1224969,EBI-608057

GO - Molecular functioni

  • thyroid hormone receptor binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi128677, 17 interactors
DIPiDIP-38114N
IntActiQ15652, 14 interactors
MINTiQ15652
STRINGi9606.ENSP00000382204

Chemistry databases

BindingDBiQ15652

Structurei

Secondary structure

12540
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2159 – 2162Combined sources4
Turni2163 – 2166Combined sources4
Beta strandi2167 – 2170Combined sources4
Helixi2178 – 2186Combined sources9
Turni2187 – 2189Combined sources3
Beta strandi2192 – 2194Combined sources3
Helixi2197 – 2199Combined sources3
Helixi2203 – 2206Combined sources4
Helixi2208 – 2215Combined sources8
Turni2225 – 2227Combined sources3
Helixi2235 – 2243Combined sources9
Helixi2245 – 2247Combined sources3
Beta strandi2259 – 2261Combined sources3
Beta strandi2264 – 2266Combined sources3
Helixi2268 – 2273Combined sources6
Helixi2275 – 2284Combined sources10
Helixi2288 – 2291Combined sources4
Turni2300 – 2302Combined sources3
Helixi2305 – 2307Combined sources3
Beta strandi2315 – 2319Combined sources5
Turni2323 – 2326Combined sources4
Beta strandi2332 – 2337Combined sources6
Beta strandi2339 – 2350Combined sources12
Helixi2360 – 2368Combined sources9
Helixi2374 – 2381Combined sources8
Beta strandi2387 – 2394Combined sources8
Helixi2396 – 2398Combined sources3
Helixi2399 – 2412Combined sources14
Helixi2423 – 2426Combined sources4
Helixi2433 – 2443Combined sources11
Beta strandi2448 – 2453Combined sources6
Beta strandi2457 – 2460Combined sources4
Beta strandi2465 – 2481Combined sources17
Helixi2484 – 2486Combined sources3
Helixi2487 – 2496Combined sources10

3D structure databases

ProteinModelPortaliQ15652
SMRiQ15652
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2274 – 2498JmjCPROSITE-ProRule annotationAdd BLAST225

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2066 – 2070LXXLL motif5

Domaini

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the JHDM2 histone demethylase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1846 – 1871C6-typeSequence analysisAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
GeneTreeiENSGT00530000063039
HOVERGENiHBG079631
InParanoidiQ15652
KOiK11449
OMAiHDIGTTN
OrthoDBiEOG091G00RB
PhylomeDBiQ15652
TreeFamiTF324723

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15652-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS 
        60         70         80         90        100
RNPDLAVYVE FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG 
       110        120        130        140        150
SKSKQIQWPA LTFKPLVERN IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD 
       160        170        180        190        200
DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE IFMQGPYSLN GYRVRVYRQD 
       210        220        230        240        250
SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM TFLDDVVHSL 
       260        270        280        290        300
LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT 
       310        320        330        340        350
HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN 
       360        370        380        390        400
KRRKPEEDEK KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE 
       410        420        430        440        450
LKNKNTSKIN GEEGKPHNNE KAGEETLKNS QPPWDQIQED KKHEEAEKRK 
       460        470        480        490        500
SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP QECNMDKTHT MELLPKEKFV 
       510        520        530        540        550
SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN VSDSKHSIAN 
       560        570        580        590        600
AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI 
       610        620        630        640        650
SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT 
       660        670        680        690        700
HSPDSVKSKA TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK 
       710        720        730        740        750
SPLIIDKNEH FTVYRDPALI GSETGANHIS PFLSQHPFPL HSSSHRTCLN 
       760        770        780        790        800
PGTHHPALTP APHLLAGSSS QTPLPTINTH PLTSGPHHAV HHPHLLPTVL 
       810        820        830        840        850
PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ SPHLLGQAHP 
       860        870        880        890        900
SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS 
       910        920        930        940        950
PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL 
       960        970        980        990       1000
VDHHKEELER KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV 
      1010       1020       1030       1040       1050
LNQLQRPPQE TGERLNKYKE EHRRILQESI DVAPFTTKIK GLEGERENYS 
      1060       1070       1080       1090       1100
RVASSSSSPK SHIIKQDMDV ERSVSDLYKM KHSVPQSLPQ SNYFTTLSNS 
      1110       1120       1130       1140       1150
VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI TSLSKPPPLI 
      1160       1170       1180       1190       1200
KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM 
      1210       1220       1230       1240       1250
PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP 
      1260       1270       1280       1290       1300
PTLIPEPKDS QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA 
      1310       1320       1330       1340       1350
AMASVIVRPS SSTKTDSMPA MQLASKDRVS ERSSAGAHKT DCLKLAEAGE 
      1360       1370       1380       1390       1400
TGRIILPNVN SDSVHTKSEK NFQAVSQGSV PSSVMSAVNT MCNTKTDVIT 
      1410       1420       1430       1440       1450
SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ PVAQKQECKV 
      1460       1470       1480       1490       1500
STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS 
      1510       1520       1530       1540       1550
ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL 
      1560       1570       1580       1590       1600
KKAWLTRHSE EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS 
      1610       1620       1630       1640       1650
KIIVDKYVKD DKVNRRKAKR TYESGSESGD SDESESKSEQ RTKRQPKPTY 
      1660       1670       1680       1690       1700
KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE RSKLKLQSNS NTGIPRSVLK 
      1710       1720       1730       1740       1750
DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK KGEEPAHSPV 
      1760       1770       1780       1790       1800
FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE 
      1810       1820       1830       1840       1850
TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE 
      1860       1870       1880       1890       1900
ATLFNIHWVC QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK 
      1910       1920       1930       1940       1950
HLMPTQIIPG SVLTDLLDAM HTLREKYGIK SHCHCTNKQN LQVGNFPTMN 
      1960       1970       1980       1990       2000
GVSQVLQNVL NHSNKISLCM PESQQQNTPP KSEKNGGSSP ESDVGTDNKL 
      2010       2020       2030       2040       2050
TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER EQDNSESPNG 
      2060       2070       2080       2090       2100
RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK 
      2110       2120       2130       2140       2150
SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN 
      2160       2170       2180       2190       2200
NKLYSDIPHS WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK 
      2210       2220       2230       2240       2250
MNISLWKAES ISLDFGDHQA DLLNCKDSII SNANVKEFWD GFEEVSKRQK 
      2260       2270       2280       2290       2300
NKSGETVVLK LKDWPSGEDF KTMMPARYED LLKSLPLPEY CNPEGKFNLA 
      2310       2320       2330       2340       2350
SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS DVVNILVYVG 
      2360       2370       2380       2390       2400
IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD 
      2410       2420       2430       2440       2450
KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL 
      2460       2470       2480       2490       2500
IQFLGDAIVL PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL 
      2510       2520       2530       2540
KEEINYDDKL QVKNILYHAV KEMVRALKIH EDEVEDMEEN
Length:2,540
Mass (Da):284,525
Last modified:January 10, 2006 - v2
Checksum:i8B1727414D6B677F
GO
Isoform 2 (identifier: Q15652-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.
     1692-1699: TGIPRSVL → SCHLVKTE
     1700-2540: Missing.

Note: No experimental confirmation available.
Show »
Length:1,480
Mass (Da):163,133
Checksum:i72DB291B3FAB25B7
GO
Isoform 3 (identifier: Q15652-3) [UniParc]FASTAAdd to basket
Also known as: s-JMJD1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Note: May function as a tumor suppressor, reduced expression in breast cancer tumors.
Show »
Length:2,358
Mass (Da):263,157
Checksum:i6005F440A38FC096
GO

Sequence cautioni

The sequence AAC41741 differs from that shown. Reason: Frameshift at position 2171.Curated
The sequence CAD97921 differs from that shown. Reason: Frameshift at position 1697.Curated
The sequence CAI10947 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti488T → A in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti779T → A in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti783T → P in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti2093S → A in AAC41741 (PubMed:7776974).Curated1
Sequence conflicti2148Missing in BAA92618 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049654272A → T. Corresponds to variant dbSNP:rs34798625EnsemblClinVar.1
Natural variantiVAR_049655394E → D. Corresponds to variant dbSNP:rs35380596Ensembl.1
Natural variantiVAR_049656464S → T1 PublicationCorresponds to variant dbSNP:rs10761725Ensembl.1
Natural variantiVAR_061277591M → V. Corresponds to variant dbSNP:rs41274072EnsemblClinVar.1
Natural variantiVAR_0496571393N → Y. Corresponds to variant dbSNP:rs9703886Ensembl.1
Natural variantiVAR_0496582400D → E. Corresponds to variant dbSNP:rs34491125EnsemblClinVar.1
Natural variantiVAR_0496592535E → D1 PublicationCorresponds to variant dbSNP:rs1935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183031 – 219Missing in isoform 2. 1 PublicationAdd BLAST219
Alternative sequenceiVSP_0439091 – 182Missing in isoform 3. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_0183041692 – 1699TGIPRSVL → SCHLVKTE in isoform 2. 1 Publication8
Alternative sequenceiVSP_0183051700 – 2540Missing in isoform 2. 1 PublicationAdd BLAST841

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF068222 mRNA Translation: ABK64187.1
BX537954 mRNA Translation: CAD97921.1 Frameshift.
AL713895 Genomic DNA Translation: CAI10947.1 Sequence problems.
AL713895, AL590502 Genomic DNA Translation: CAI10948.1
AL713895, AL607128, AC022022 Genomic DNA Translation: CAI10950.1
AL607128, AL713895, AC022022 Genomic DNA Translation: CAI14188.1
AK027280 mRNA No translation available.
AL831917 mRNA Translation: CAD38578.1
AB037801 mRNA Translation: BAA92618.1
L40411 mRNA Translation: AAC41741.1 Frameshift.
CCDSiCCDS41532.1 [Q15652-1]
CCDS60538.1 [Q15652-3]
RefSeqiNP_001269877.1, NM_001282948.1 [Q15652-3]
NP_001305082.1, NM_001318153.1
NP_001305083.1, NM_001318154.1 [Q15652-3]
NP_001309181.1, NM_001322252.1
NP_001309183.1, NM_001322254.1
NP_001309187.1, NM_001322258.1
NP_116165.1, NM_032776.2 [Q15652-1]
XP_016871386.1, XM_017015897.1 [Q15652-3]
XP_016871387.1, XM_017015898.1 [Q15652-3]
UniGeneiHs.413416

Genome annotation databases

EnsembliENST00000399262; ENSP00000382204; ENSG00000171988 [Q15652-1]
ENST00000542921; ENSP00000444682; ENSG00000171988 [Q15652-3]
GeneIDi221037
KEGGihsa:221037
UCSCiuc001jmn.5 human [Q15652-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiJHD2C_HUMAN
AccessioniPrimary (citable) accession number: Q15652
Secondary accession number(s): A0T124
, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2006
Last modified: July 18, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health