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UniProtKB - Q15652 (JHD2C_HUMAN)

Protein

Probable JmjC domain-containing histone demethylation protein 2C

Gene

JMJD1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).By similarity

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2336Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2338Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2466Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1846 – 1871C6-typeSequence analysisAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin DNA binding Source: GO_Central
  • dioxygenase activity Source: UniProtKB-KW
  • histone demethylase activity (H3-K9 specific) Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • thyroid hormone receptor binding Source: UniProtKB
  • transcription regulatory region sequence-specific DNA binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable JmjC domain-containing histone demethylation protein 2C (EC:1.14.11.-)
Alternative name(s):
Jumonji domain-containing protein 1C
Thyroid receptor-interacting protein 8
Short name:
TR-interacting protein 8
Short name:
TRIP-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JMJD1C
Synonyms:JHDM2C, KIAA1380, TRIP8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000171988.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:12313 JMJD1C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604503 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15652

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		221037

MalaCards human disease database

More...MalaCardsi		JMJD1C

Open Targets

More...OpenTargetsi		ENSG00000171988

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		567 22q11.2 deletion syndrome
91352 Germinoma of the central nervous system

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394767

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3792271

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		JMJD1C

Domain mapping of disease mutations (DMDM)

More...DMDMi		85541650

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000842841 – 2540Probable JmjC domain-containing histone demethylation protein 2CAdd BLAST2540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei317PhosphoserineCombined sources1
Modified residuei320PhosphoserineBy similarity1
Modified residuei373PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei475PhosphoserineBy similarity1
Modified residuei501PhosphoserineCombined sources1
Modified residuei505PhosphothreonineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei943PhosphoserineCombined sources1
Modified residuei1989PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki2132Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15652

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15652

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15652

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15652

PeptideAtlas

More...PeptideAtlasi		Q15652

PRoteomics IDEntifications database

More...PRIDEi		Q15652

ProteomicsDB human proteome resource

More...ProteomicsDBi		60691
60692 [Q15652-2]
60693 [Q15652-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15652

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15652

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171988 Expressed in 229 organ(s), highest expression level in intestine

CleanEx database of gene expression profiles

More...CleanExi		HS_JMJD1C

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15652 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15652 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA056175
HPA066195

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102752EBI-1224969,EBI-608057

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		128677, 18 interactors

Database of interacting proteins

More...DIPi		DIP-38114N

Protein interaction database and analysis system

More...IntActi		Q15652, 15 interactors

Molecular INTeraction database

More...MINTi		Q15652

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000382204

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q15652

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12540
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPDX-ray2.10A/B2157-2540[»]
5FZOX-ray1.84A/B2157-2500[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q15652

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15652

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2274 – 2498JmjCPROSITE-ProRule annotationAdd BLAST225

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2066 – 2070LXXLL motif5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JHDM2 histone demethylase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1846 – 1871C6-typeSequence analysisAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1356 Eukaryota
ENOG410XTAA LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158210

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG079631

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15652

KEGG Orthology (KO)

More...KOi		K11449

Identification of Orthologs from Complete Genome Data

More...OMAi		EMWKSNN

Database of Orthologous Groups

More...OrthoDBi		1185631at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15652

TreeFam database of animal gene trees

More...TreeFami		TF324723

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003347 JmjC_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02373 JmjC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00558 JmjC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51184 JMJC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15652-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS 
        60         70         80         90        100
RNPDLAVYVE FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG 
       110        120        130        140        150
SKSKQIQWPA LTFKPLVERN IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD 
       160        170        180        190        200
DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE IFMQGPYSLN GYRVRVYRQD 
       210        220        230        240        250
SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM TFLDDVVHSL 
       260        270        280        290        300
LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT 
       310        320        330        340        350
HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN 
       360        370        380        390        400
KRRKPEEDEK KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE 
       410        420        430        440        450
LKNKNTSKIN GEEGKPHNNE KAGEETLKNS QPPWDQIQED KKHEEAEKRK 
       460        470        480        490        500
SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP QECNMDKTHT MELLPKEKFV 
       510        520        530        540        550
SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN VSDSKHSIAN 
       560        570        580        590        600
AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI 
       610        620        630        640        650
SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT 
       660        670        680        690        700
HSPDSVKSKA TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK 
       710        720        730        740        750
SPLIIDKNEH FTVYRDPALI GSETGANHIS PFLSQHPFPL HSSSHRTCLN 
       760        770        780        790        800
PGTHHPALTP APHLLAGSSS QTPLPTINTH PLTSGPHHAV HHPHLLPTVL 
       810        820        830        840        850
PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ SPHLLGQAHP 
       860        870        880        890        900
SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS 
       910        920        930        940        950
PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL 
       960        970        980        990       1000
VDHHKEELER KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV 
      1010       1020       1030       1040       1050
LNQLQRPPQE TGERLNKYKE EHRRILQESI DVAPFTTKIK GLEGERENYS 
      1060       1070       1080       1090       1100
RVASSSSSPK SHIIKQDMDV ERSVSDLYKM KHSVPQSLPQ SNYFTTLSNS 
      1110       1120       1130       1140       1150
VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI TSLSKPPPLI 
      1160       1170       1180       1190       1200
KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM 
      1210       1220       1230       1240       1250
PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP 
      1260       1270       1280       1290       1300
PTLIPEPKDS QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA 
      1310       1320       1330       1340       1350
AMASVIVRPS SSTKTDSMPA MQLASKDRVS ERSSAGAHKT DCLKLAEAGE 
      1360       1370       1380       1390       1400
TGRIILPNVN SDSVHTKSEK NFQAVSQGSV PSSVMSAVNT MCNTKTDVIT 
      1410       1420       1430       1440       1450
SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ PVAQKQECKV 
      1460       1470       1480       1490       1500
STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS 
      1510       1520       1530       1540       1550
ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL 
      1560       1570       1580       1590       1600
KKAWLTRHSE EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS 
      1610       1620       1630       1640       1650
KIIVDKYVKD DKVNRRKAKR TYESGSESGD SDESESKSEQ RTKRQPKPTY 
      1660       1670       1680       1690       1700
KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE RSKLKLQSNS NTGIPRSVLK 
      1710       1720       1730       1740       1750
DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK KGEEPAHSPV 
      1760       1770       1780       1790       1800
FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE 
      1810       1820       1830       1840       1850
TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE 
      1860       1870       1880       1890       1900
ATLFNIHWVC QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK 
      1910       1920       1930       1940       1950
HLMPTQIIPG SVLTDLLDAM HTLREKYGIK SHCHCTNKQN LQVGNFPTMN 
      1960       1970       1980       1990       2000
GVSQVLQNVL NHSNKISLCM PESQQQNTPP KSEKNGGSSP ESDVGTDNKL 
      2010       2020       2030       2040       2050
TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER EQDNSESPNG 
      2060       2070       2080       2090       2100
RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK 
      2110       2120       2130       2140       2150
SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN 
      2160       2170       2180       2190       2200
NKLYSDIPHS WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK 
      2210       2220       2230       2240       2250
MNISLWKAES ISLDFGDHQA DLLNCKDSII SNANVKEFWD GFEEVSKRQK 
      2260       2270       2280       2290       2300
NKSGETVVLK LKDWPSGEDF KTMMPARYED LLKSLPLPEY CNPEGKFNLA 
      2310       2320       2330       2340       2350
SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS DVVNILVYVG 
      2360       2370       2380       2390       2400
IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD 
      2410       2420       2430       2440       2450
KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL 
      2460       2470       2480       2490       2500
IQFLGDAIVL PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL 
      2510       2520       2530       2540
KEEINYDDKL QVKNILYHAV KEMVRALKIH EDEVEDMEEN
Length:2,540
Mass (Da):284,525
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B1727414D6B677F
GO
Isoform 2 (identifier: Q15652-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.
     1692-1699: TGIPRSVL → SCHLVKTE
     1700-2540: Missing.

Note: No experimental confirmation available.
Show »
Length:1,480
Mass (Da):163,133
Checksum:i72DB291B3FAB25B7
GO
Isoform 3 (identifier: Q15652-3) [UniParc]FASTAAdd to basket
Also known as: s-JMJD1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Note: May function as a tumor suppressor, reduced expression in breast cancer tumors.
Show »
Length:2,358
Mass (Da):263,157
Checksum:i6005F440A38FC096
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXU7H7BXU7_HUMAN
Probable JmjC domain-containing his...
JMJD1C
956Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PNZ9A0A1W2PNZ9_HUMAN
Probable JmjC domain-containing his...
JMJD1C
2,358Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC41741 differs from that shown. Reason: Frameshift at position 2171.Curated
The sequence CAD97921 differs from that shown. Reason: Frameshift at position 1697.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti488T → A in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti779T → A in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti783T → P in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti2093S → A in AAC41741 (PubMed:7776974).Curated1
Sequence conflicti2148Missing in BAA92618 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049654272A → T. Corresponds to variant dbSNP:rs34798625EnsemblClinVar.1
Natural variantiVAR_049655394E → D. Corresponds to variant dbSNP:rs35380596Ensembl.1
Natural variantiVAR_049656464S → T1 PublicationCorresponds to variant dbSNP:rs10761725Ensembl.1
Natural variantiVAR_061277591M → V. Corresponds to variant dbSNP:rs41274072EnsemblClinVar.1
Natural variantiVAR_0496571393N → Y. Corresponds to variant dbSNP:rs9703886Ensembl.1
Natural variantiVAR_0496582400D → E. Corresponds to variant dbSNP:rs34491125EnsemblClinVar.1
Natural variantiVAR_0496592535E → D1 PublicationCorresponds to variant dbSNP:rs1935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0183031 – 219Missing in isoform 2. 1 PublicationAdd BLAST219
Alternative sequenceiVSP_0439091 – 182Missing in isoform 3. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_0183041692 – 1699TGIPRSVL → SCHLVKTE in isoform 2. 1 Publication8
Alternative sequenceiVSP_0183051700 – 2540Missing in isoform 2. 1 PublicationAdd BLAST841

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EF068222 mRNA Translation: ABK64187.1
BX537954 mRNA Translation: CAD97921.1 Frameshift.
AC022022 Genomic DNA No translation available.
AL590502 Genomic DNA No translation available.
AL607128 Genomic DNA No translation available.
AL713895 Genomic DNA No translation available.
AK027280 mRNA No translation available.
AL831917 mRNA Translation: CAD38578.1
AB037801 mRNA Translation: BAA92618.1
L40411 mRNA Translation: AAC41741.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41532.1 [Q15652-1]
CCDS60538.1 [Q15652-3]

NCBI Reference Sequences

More...RefSeqi		NP_001269877.1, NM_001282948.1 [Q15652-3]
NP_001305082.1, NM_001318153.1
NP_001305083.1, NM_001318154.1 [Q15652-3]
NP_001309181.1, NM_001322252.1
NP_001309183.1, NM_001322254.1
NP_001309187.1, NM_001322258.1
NP_116165.1, NM_032776.2 [Q15652-1]
XP_016871386.1, XM_017015897.1 [Q15652-3]
XP_016871387.1, XM_017015898.1 [Q15652-3]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.413416

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000399262; ENSP00000382204; ENSG00000171988 [Q15652-1]
ENST00000542921; ENSP00000444682; ENSG00000171988 [Q15652-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		221037

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:221037

UCSC genome browser

More...UCSCi		uc001jmn.5 human [Q15652-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF068222 mRNA Translation: ABK64187.1
BX537954 mRNA Translation: CAD97921.1 Frameshift.
AC022022 Genomic DNA No translation available.
AL590502 Genomic DNA No translation available.
AL607128 Genomic DNA No translation available.
AL713895 Genomic DNA No translation available.
AK027280 mRNA No translation available.
AL831917 mRNA Translation: CAD38578.1
AB037801 mRNA Translation: BAA92618.1
L40411 mRNA Translation: AAC41741.1 Frameshift.
CCDSiCCDS41532.1 [Q15652-1]
CCDS60538.1 [Q15652-3]
RefSeqiNP_001269877.1, NM_001282948.1 [Q15652-3]
NP_001305082.1, NM_001318153.1
NP_001305083.1, NM_001318154.1 [Q15652-3]
NP_001309181.1, NM_001322252.1
NP_001309183.1, NM_001322254.1
NP_001309187.1, NM_001322258.1
NP_116165.1, NM_032776.2 [Q15652-1]
XP_016871386.1, XM_017015897.1 [Q15652-3]
XP_016871387.1, XM_017015898.1 [Q15652-3]
UniGeneiHs.413416

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPDX-ray2.10A/B2157-2540[»]
5FZOX-ray1.84A/B2157-2500[»]
ProteinModelPortaliQ15652
SMRiQ15652
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128677, 18 interactors
DIPiDIP-38114N
IntActiQ15652, 15 interactors
MINTiQ15652
STRINGi9606.ENSP00000382204

Chemistry databases

BindingDBiQ15652
ChEMBLiCHEMBL3792271

PTM databases

iPTMnetiQ15652
PhosphoSitePlusiQ15652

Polymorphism and mutation databases

BioMutaiJMJD1C
DMDMi85541650

Proteomic databases

EPDiQ15652
jPOSTiQ15652
MaxQBiQ15652
PaxDbiQ15652
PeptideAtlasiQ15652
PRIDEiQ15652
ProteomicsDBi60691
60692 [Q15652-2]
60693 [Q15652-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399262; ENSP00000382204; ENSG00000171988 [Q15652-1]
ENST00000542921; ENSP00000444682; ENSG00000171988 [Q15652-3]
GeneIDi221037
KEGGihsa:221037
UCSCiuc001jmn.5 human [Q15652-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		221037
DisGeNETi221037
EuPathDBiHostDB:ENSG00000171988.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		JMJD1C

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0008863
HGNCiHGNC:12313 JMJD1C
HPAiHPA056175
HPA066195
MalaCardsiJMJD1C
MIMi604503 gene
neXtProtiNX_Q15652
OpenTargetsiENSG00000171988
Orphaneti567 22q11.2 deletion syndrome
91352 Germinoma of the central nervous system
PharmGKBiPA128394767

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
GeneTreeiENSGT00940000158210
HOVERGENiHBG079631
InParanoidiQ15652
KOiK11449
OMAiEMWKSNN
OrthoDBi1185631at2759
PhylomeDBiQ15652
TreeFamiTF324723

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		JMJD1C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		221037

Protein Ontology

More...PROi		PR:Q15652

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171988 Expressed in 229 organ(s), highest expression level in intestine
CleanExiHS_JMJD1C
ExpressionAtlasiQ15652 baseline and differential
GenevisibleiQ15652 HS

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJHD2C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15652
Secondary accession number(s): A0T124
, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2006
Last modified: January 16, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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