JMJD1C

Functionⁱ

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).

By similarity

Cofactorⁱ

Fe²⁺By similarityNote: Binds 1 Fe²⁺ ion per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	2336	Iron; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	2338	Iron; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	2466	Iron; catalyticPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1846 – 1871	C6-typeSequence analysisAdd BLAST		26

GO - Molecular functionⁱ

chromatin DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
dioxygenase activity Source: UniProtKB-KW
histone demethylase activity (H3-K9 specific)
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
metal ion binding Source: UniProtKB-KW
thyroid hormone receptor binding
Source: UniProtKB
Traceable author statementⁱ
- Ref.6
  "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
  Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.
  Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2030-2212, INTERACTION WITH THYROID RECEPTOR.
transcription coregulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Dioxygenase, Oxidoreductase
Biological process	Transcription, Transcription regulation
Ligand	Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000171988-MONOMER
BRENDAⁱ	1.14.11.65, 2681
PathwayCommonsⁱ	Q15652
Reactomeⁱ	R-HSA-983231, Factors involved in megakaryocyte development and platelet production

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable JmjC domain-containing histone demethylation protein 2C (EC:1.14.11.-) Alternative name(s): Jumonji domain-containing protein 1C Thyroid receptor-interacting protein 8 Short name: TR-interacting protein 8 Short name: TRIP-8
Gene namesⁱ	Name:JMJD1C Synonyms:JHDM2C, KIAA1380, TRIP8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12313, JMJD1C
MIMⁱ	604503, gene
neXtProtⁱ	NX_Q15652
VEuPathDBⁱ	HostDB:ENSG00000171988.17

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	221037
MalaCards human disease database More...MalaCardsⁱ	JMJD1C
Open Targets More...OpenTargetsⁱ	ENSG00000171988
Orphanetⁱ	567, 22q11.2 deletion syndrome 91352, Germinoma of the central nervous system
PharmGKBⁱ	PA128394767

Miscellaneous databases

Pharosⁱ	Q15652, Tbio

Pharosⁱ

Q15652, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL3792271

ChEMBLⁱ

CHEMBL3792271

Genetic variation databases

BioMutaⁱ	JMJD1C
DMDMⁱ	85541650

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084284	1 – 2540	Probable JmjC domain-containing histone demethylation protein 2CAdd BLAST		2540

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	317	PhosphoserineCombined sources	1
Modified residueⁱ	320	PhosphoserineBy similarity	1
Modified residueⁱ	373	PhosphoserineCombined sources	1
Modified residueⁱ	376	PhosphoserineCombined sources	1
Modified residueⁱ	475	PhosphoserineBy similarity	1
Modified residueⁱ	501	PhosphoserineCombined sources	1
Modified residueⁱ	505	PhosphothreonineCombined sources	1
Modified residueⁱ	601	PhosphoserineCombined sources	1
Modified residueⁱ	617	PhosphoserineCombined sources	1
Modified residueⁱ	638	PhosphoserineCombined sources	1
Modified residueⁱ	639	PhosphoserineCombined sources	1
Modified residueⁱ	641	PhosphoserineCombined sources	1
Modified residueⁱ	652	PhosphoserineCombined sources	1
Modified residueⁱ	943	PhosphoserineCombined sources	1
Modified residueⁱ	1989	PhosphoserineCombined sources	1
Cross-linkⁱ	2132	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	2136	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q15652
jPOSTⁱ	Q15652
MassIVEⁱ	Q15652
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15652
PaxDbⁱ	Q15652
PeptideAtlas More...PeptideAtlasⁱ	Q15652
PRIDEⁱ	Q15652
ProteomicsDBⁱ	60691 [Q15652-1] 60692 [Q15652-2] 60693 [Q15652-3]

PTM databases

GlyGenⁱ	Q15652, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetⁱ	Q15652
PhosphoSitePlusⁱ	Q15652

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171988, Expressed in intestine and 241 other tissues
ExpressionAtlasⁱ	Q15652, baseline and differential
Genevisibleⁱ	Q15652, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000171988, Low tissue specificity

HPAⁱ

ENSG00000171988, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.

1 Publication

Binary interactionsⁱ

Q15652

With	#Exp.	IntAct
AR [P10275]	2	EBI-1224969,EBI-608057

GO - Molecular functionⁱ

thyroid hormone receptor binding
Source: UniProtKB
Traceable author statementⁱ
- Ref.6
  "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
  Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.
  Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2030-2212, INTERACTION WITH THYROID RECEPTOR.

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	128677, 42 interactors
Database of interacting proteins More...DIPⁱ	DIP-38114N
IntActⁱ	Q15652, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q15652
STRINGⁱ	9606.ENSP00000382204

Chemistry databases

BindingDBⁱ

Q15652

Miscellaneous databases

RNActⁱ	Q15652, protein

RNActⁱ

Q15652, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	2159 – 2162	Combined sources	4
Turnⁱ	2163 – 2166	Combined sources	4
Beta strandⁱ	2167 – 2170	Combined sources	4
Helixⁱ	2178 – 2186	Combined sources	9
Turnⁱ	2187 – 2189	Combined sources	3
Beta strandⁱ	2192 – 2194	Combined sources	3
Helixⁱ	2197 – 2199	Combined sources	3
Helixⁱ	2203 – 2206	Combined sources	4
Helixⁱ	2208 – 2215	Combined sources	8
Turnⁱ	2225 – 2227	Combined sources	3
Helixⁱ	2235 – 2243	Combined sources	9
Helixⁱ	2245 – 2247	Combined sources	3
Beta strandⁱ	2259 – 2261	Combined sources	3
Beta strandⁱ	2264 – 2266	Combined sources	3
Helixⁱ	2268 – 2273	Combined sources	6
Helixⁱ	2275 – 2284	Combined sources	10
Helixⁱ	2288 – 2291	Combined sources	4
Turnⁱ	2300 – 2302	Combined sources	3
Helixⁱ	2305 – 2307	Combined sources	3
Beta strandⁱ	2315 – 2319	Combined sources	5
Turnⁱ	2323 – 2326	Combined sources	4
Beta strandⁱ	2332 – 2337	Combined sources	6
Beta strandⁱ	2339 – 2350	Combined sources	12
Helixⁱ	2360 – 2368	Combined sources	9
Helixⁱ	2374 – 2381	Combined sources	8
Beta strandⁱ	2387 – 2394	Combined sources	8
Helixⁱ	2396 – 2398	Combined sources	3
Helixⁱ	2399 – 2412	Combined sources	14
Helixⁱ	2423 – 2426	Combined sources	4
Helixⁱ	2433 – 2443	Combined sources	11
Beta strandⁱ	2448 – 2453	Combined sources	6
Beta strandⁱ	2457 – 2460	Combined sources	4
Beta strandⁱ	2465 – 2481	Combined sources	17
Helixⁱ	2484 – 2486	Combined sources	3
Helixⁱ	2487 – 2496	Combined sources	10

Show more details

3D structure databases

SMRⁱ	Q15652
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2274 – 2498	JmjCPROSITE-ProRule annotationAdd BLAST		225

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	278 – 478	DisorderedSequence analysisAdd BLAST	201
Regionⁱ	631 – 656	DisorderedSequence analysisAdd BLAST	26
Regionⁱ	1242 – 1263	DisorderedSequence analysisAdd BLAST	22
Regionⁱ	1614 – 1692	DisorderedSequence analysisAdd BLAST	79
Regionⁱ	1971 – 2064	DisorderedSequence analysisAdd BLAST	94

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	2066 – 2070	LXXLL motif		5

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	278 – 310	Polar residuesSequence analysisAdd BLAST	33
Compositional biasⁱ	311 – 424	Basic and acidic residuesSequence analysisAdd BLAST	114
Compositional biasⁱ	435 – 456	Basic and acidic residuesSequence analysisAdd BLAST	22
Compositional biasⁱ	457 – 478	Polar residuesSequence analysisAdd BLAST	22
Compositional biasⁱ	1614 – 1683	Basic and acidic residuesSequence analysisAdd BLAST	70
Compositional biasⁱ	1971 – 2005	Polar residuesSequence analysisAdd BLAST	35
Compositional biasⁱ	2015 – 2046	Basic and acidic residuesSequence analysisAdd BLAST	32
Compositional biasⁱ	2047 – 2064	Polar residuesSequence analysisAdd BLAST	18

Domainⁱ

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

Sequence similaritiesⁱ

Belongs to the JHDM2 histone demethylase family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1846 – 1871	C6-typeSequence analysisAdd BLAST		26

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1356, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158210
HOGENOMⁱ	CLU_228251_0_0_1
InParanoidⁱ	Q15652
OMAⁱ	FMSSLNV
Database of Orthologous Groups More...OrthoDBⁱ	1185631at2759
PhylomeDBⁱ	Q15652
TreeFamⁱ	TF324723

Family and domain databases

InterProⁱ	View protein in InterPro IPR003347, JmjC_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02373, JmjC, 1 hit
SMARTⁱ	View protein in SMART SM00558, JmjC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51184, JMJC, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15652-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS 
        60         70         80         90        100
RNPDLAVYVE FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG 
       110        120        130        140        150
SKSKQIQWPA LTFKPLVERN IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD 
       160        170        180        190        200
DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE IFMQGPYSLN GYRVRVYRQD 
       210        220        230        240        250
SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM TFLDDVVHSL 
       260        270        280        290        300
LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT 
       310        320        330        340        350
HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN 
       360        370        380        390        400
KRRKPEEDEK KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE 
       410        420        430        440        450
LKNKNTSKIN GEEGKPHNNE KAGEETLKNS QPPWDQIQED KKHEEAEKRK 
       460        470        480        490        500
SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP QECNMDKTHT MELLPKEKFV 
       510        520        530        540        550
SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN VSDSKHSIAN 
       560        570        580        590        600
AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI 
       610        620        630        640        650
SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT 
       660        670        680        690        700
HSPDSVKSKA TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK 
       710        720        730        740        750
SPLIIDKNEH FTVYRDPALI GSETGANHIS PFLSQHPFPL HSSSHRTCLN 
       760        770        780        790        800
PGTHHPALTP APHLLAGSSS QTPLPTINTH PLTSGPHHAV HHPHLLPTVL 
       810        820        830        840        850
PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ SPHLLGQAHP 
       860        870        880        890        900
SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS 
       910        920        930        940        950
PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL 
       960        970        980        990       1000
VDHHKEELER KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV 
      1010       1020       1030       1040       1050
LNQLQRPPQE TGERLNKYKE EHRRILQESI DVAPFTTKIK GLEGERENYS 
      1060       1070       1080       1090       1100
RVASSSSSPK SHIIKQDMDV ERSVSDLYKM KHSVPQSLPQ SNYFTTLSNS 
      1110       1120       1130       1140       1150
VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI TSLSKPPPLI 
      1160       1170       1180       1190       1200
KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM 
      1210       1220       1230       1240       1250
PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP 
      1260       1270       1280       1290       1300
PTLIPEPKDS QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA 
      1310       1320       1330       1340       1350
AMASVIVRPS SSTKTDSMPA MQLASKDRVS ERSSAGAHKT DCLKLAEAGE 
      1360       1370       1380       1390       1400
TGRIILPNVN SDSVHTKSEK NFQAVSQGSV PSSVMSAVNT MCNTKTDVIT 
      1410       1420       1430       1440       1450
SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ PVAQKQECKV 
      1460       1470       1480       1490       1500
STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS 
      1510       1520       1530       1540       1550
ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL 
      1560       1570       1580       1590       1600
KKAWLTRHSE EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS 
      1610       1620       1630       1640       1650
KIIVDKYVKD DKVNRRKAKR TYESGSESGD SDESESKSEQ RTKRQPKPTY 
      1660       1670       1680       1690       1700
KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE RSKLKLQSNS NTGIPRSVLK 
      1710       1720       1730       1740       1750
DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK KGEEPAHSPV 
      1760       1770       1780       1790       1800
FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE 
      1810       1820       1830       1840       1850
TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE 
      1860       1870       1880       1890       1900
ATLFNIHWVC QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK 
      1910       1920       1930       1940       1950
HLMPTQIIPG SVLTDLLDAM HTLREKYGIK SHCHCTNKQN LQVGNFPTMN 
      1960       1970       1980       1990       2000
GVSQVLQNVL NHSNKISLCM PESQQQNTPP KSEKNGGSSP ESDVGTDNKL 
      2010       2020       2030       2040       2050
TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER EQDNSESPNG 
      2060       2070       2080       2090       2100
RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK 
      2110       2120       2130       2140       2150
SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN 
      2160       2170       2180       2190       2200
NKLYSDIPHS WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK 
      2210       2220       2230       2240       2250
MNISLWKAES ISLDFGDHQA DLLNCKDSII SNANVKEFWD GFEEVSKRQK 
      2260       2270       2280       2290       2300
NKSGETVVLK LKDWPSGEDF KTMMPARYED LLKSLPLPEY CNPEGKFNLA 
      2310       2320       2330       2340       2350
SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS DVVNILVYVG 
      2360       2370       2380       2390       2400
IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD 
      2410       2420       2430       2440       2450
KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL 
      2460       2470       2480       2490       2500
IQFLGDAIVL PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL 
      2510       2520       2530       2540
KEEINYDDKL QVKNILYHAV KEMVRALKIH EDEVEDMEEN

Length:2,540

Mass (Da):284,525

Last modified:January 10, 2006 - v2

Checksum:ⁱ8B1727414D6B677F

GO

Isoform 2 (identifier: Q15652-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.
     1692-1699: TGIPRSVL → SCHLVKTE
     1700-2540: Missing.

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        10         20         30         40         50
MIVMNDQVLE PQNVDPSMVQ MTFLDDVVHS LLKGENIGIT SRRRSRANQN 
        60         70         80         90        100
VNAVHSHYTR AQANSPRPAM NSQAAVPKQN THQQQQQRSI RPNKRKGSDS 
       110        120        130        140        150
SIPDEEKMKE EKYDYISRGE NPKGKNKHLM NKRRKPEEDE KKLNMKRLRT 
       160        170        180        190        200
DNVSDFSESS DSENSNKRII DNSSEQKPEN ELKNKNTSKI NGEEGKPHNN 
       210        220        230        240        250
EKAGEETLKN SQPPWDQIQE DKKHEEAEKR KSVDTQLQED MIIHSSEQST 
       260        270        280        290        300
VSDHNSNDLL PQECNMDKTH TMELLPKEKF VSRPPTPKCV IDITNDTNLE 
       310        320        330        340        350
KVAQENSSTF GLQTLQKMDP NVSDSKHSIA NAKFLETAKK DSDQSWVSDV 
       360        370        380        390        400
VKVDLTQSSV TNASSGNDHL NMEKEKYVSY ISPLSAVSVM EDKLHKRSPP 
       410        420        430        440        450
PETIKSKLNT SVDTHKIKSS PSPEVVKPKI THSPDSVKSK ATYVNSQATG 
       460        470        480        490        500
ERRLANKIEH ELSRCSFHPI PTRSSTLETT KSPLIIDKNE HFTVYRDPAL 
       510        520        530        540        550
IGSETGANHI SPFLSQHPFP LHSSSHRTCL NPGTHHPALT PAPHLLAGSS 
       560        570        580        590        600
SQTPLPTINT HPLTSGPHHA VHHPHLLPTV LPGVPTASLL GGHPRLESAH 
       610        620        630        640        650
ASSLSHLALA HQQQQQLLQH QSPHLLGQAH PSASYNQLGL YPIIWQYPNG 
       660        670        680        690        700
THAYSGLGLP SSKWVHPENA VNAEASLRRN SPSPWLHQPT PVTSADGIGL 
       710        720        730        740        750
LSHIPVRPSS AEPHRPLKIT AHSSPPLTKT LVDHHKEELE RKAFMEPLRS 
       760        770        780        790        800
VASTSAKNDL DLNRSQTGKD CHLHRHFVDP VLNQLQRPPQ ETGERLNKYK 
       810        820        830        840        850
EEHRRILQES IDVAPFTTKI KGLEGERENY SRVASSSSSP KSHIIKQDMD 
       860        870        880        890        900
VERSVSDLYK MKHSVPQSLP QSNYFTTLSN SVVNEPPRSY PSKEVSNIYG 
       910        920        930        940        950
DKQSNALAAA AANPQTLTSF ITSLSKPPPL IKHQPESEGL VGKIPEHLPH 
       960        970        980        990       1000
QIASHSVTTF RNDCRSPTHL TVSSTNTLRS MPALHRAPVF HPPIHHSLER 
      1010       1020       1030       1040       1050
KEGSYSSLSP PTLTPVMPVN AGGKVQESQK PPTLIPEPKD SQANFKSSSE 
      1060       1070       1080       1090       1100
QSLTEMWRPN NNLSKEKTEW HVEKSSGKLQ AAMASVIVRP SSSTKTDSMP 
      1110       1120       1130       1140       1150
AMQLASKDRV SERSSAGAHK TDCLKLAEAG ETGRIILPNV NSDSVHTKSE 
      1160       1170       1180       1190       1200
KNFQAVSQGS VPSSVMSAVN TMCNTKTDVI TSAADTTSVS SWGGSEVISS 
      1210       1220       1230       1240       1250
LSNTILASTS SECVSSKSVS QPVAQKQECK VSTTAPVTLA SSKTGSVVQP 
      1260       1270       1280       1290       1300
SSGFSGTTDF IHLKKHKAAL AAAQYKSSNA SETEPNAIKN QTLSASLPLD 
      1310       1320       1330       1340       1350
STVICSTINK ANSVGNGQAS QTSQPNYHTK LKKAWLTRHS EEDKNTNKME 
      1360       1370       1380       1390       1400
NSGNSVSEII KPCSVNLIAS TSSDIQNSVD SKIIVDKYVK DDKVNRRKAK 
      1410       1420       1430       1440       1450
RTYESGSESG DSDESESKSE QRTKRQPKPT YKKKQNDLQK RKGEIEEDLK 
      1460       1470       1480
PNGVLSRSAK ERSKLKLQSN SNSCHLVKTE

Show »

Length:1,480

Mass (Da):163,133

Checksum:ⁱ72DB291B3FAB25B7

GO

Isoform 3 (identifier: Q15652-3) [UniParc]FASTA Add to basket

Also known as: s-JMJD1C

The sequence of this isoform differs from the canonical sequence as follows:
1-182: Missing.

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        10         20         30         40         50
MQGPYSLNGY RVRVYRQDSA TQWFTGIITH HDLFTRTMIV MNDQVLEPQN 
        60         70         80         90        100
VDPSMVQMTF LDDVVHSLLK GENIGITSRR RSRANQNVNA VHSHYTRAQA 
       110        120        130        140        150
NSPRPAMNSQ AAVPKQNTHQ QQQQRSIRPN KRKGSDSSIP DEEKMKEEKY 
       160        170        180        190        200
DYISRGENPK GKNKHLMNKR RKPEEDEKKL NMKRLRTDNV SDFSESSDSE 
       210        220        230        240        250
NSNKRIIDNS SEQKPENELK NKNTSKINGE EGKPHNNEKA GEETLKNSQP 
       260        270        280        290        300
PWDQIQEDKK HEEAEKRKSV DTQLQEDMII HSSEQSTVSD HNSNDLLPQE 
       310        320        330        340        350
CNMDKTHTME LLPKEKFVSR PPTPKCVIDI TNDTNLEKVA QENSSTFGLQ 
       360        370        380        390        400
TLQKMDPNVS DSKHSIANAK FLETAKKDSD QSWVSDVVKV DLTQSSVTNA 
       410        420        430        440        450
SSGNDHLNME KEKYVSYISP LSAVSVMEDK LHKRSPPPET IKSKLNTSVD 
       460        470        480        490        500
THKIKSSPSP EVVKPKITHS PDSVKSKATY VNSQATGERR LANKIEHELS 
       510        520        530        540        550
RCSFHPIPTR SSTLETTKSP LIIDKNEHFT VYRDPALIGS ETGANHISPF 
       560        570        580        590        600
LSQHPFPLHS SSHRTCLNPG THHPALTPAP HLLAGSSSQT PLPTINTHPL 
       610        620        630        640        650
TSGPHHAVHH PHLLPTVLPG VPTASLLGGH PRLESAHASS LSHLALAHQQ 
       660        670        680        690        700
QQQLLQHQSP HLLGQAHPSA SYNQLGLYPI IWQYPNGTHA YSGLGLPSSK 
       710        720        730        740        750
WVHPENAVNA EASLRRNSPS PWLHQPTPVT SADGIGLLSH IPVRPSSAEP 
       760        770        780        790        800
HRPLKITAHS SPPLTKTLVD HHKEELERKA FMEPLRSVAS TSAKNDLDLN 
       810        820        830        840        850
RSQTGKDCHL HRHFVDPVLN QLQRPPQETG ERLNKYKEEH RRILQESIDV 
       860        870        880        890        900
APFTTKIKGL EGERENYSRV ASSSSSPKSH IIKQDMDVER SVSDLYKMKH 
       910        920        930        940        950
SVPQSLPQSN YFTTLSNSVV NEPPRSYPSK EVSNIYGDKQ SNALAAAAAN 
       960        970        980        990       1000
PQTLTSFITS LSKPPPLIKH QPESEGLVGK IPEHLPHQIA SHSVTTFRND 
      1010       1020       1030       1040       1050
CRSPTHLTVS STNTLRSMPA LHRAPVFHPP IHHSLERKEG SYSSLSPPTL 
      1060       1070       1080       1090       1100
TPVMPVNAGG KVQESQKPPT LIPEPKDSQA NFKSSSEQSL TEMWRPNNNL 
      1110       1120       1130       1140       1150
SKEKTEWHVE KSSGKLQAAM ASVIVRPSSS TKTDSMPAMQ LASKDRVSER 
      1160       1170       1180       1190       1200
SSAGAHKTDC LKLAEAGETG RIILPNVNSD SVHTKSEKNF QAVSQGSVPS 
      1210       1220       1230       1240       1250
SVMSAVNTMC NTKTDVITSA ADTTSVSSWG GSEVISSLSN TILASTSSEC 
      1260       1270       1280       1290       1300
VSSKSVSQPV AQKQECKVST TAPVTLASSK TGSVVQPSSG FSGTTDFIHL 
      1310       1320       1330       1340       1350
KKHKAALAAA QYKSSNASET EPNAIKNQTL SASLPLDSTV ICSTINKANS 
      1360       1370       1380       1390       1400
VGNGQASQTS QPNYHTKLKK AWLTRHSEED KNTNKMENSG NSVSEIIKPC 
      1410       1420       1430       1440       1450
SVNLIASTSS DIQNSVDSKI IVDKYVKDDK VNRRKAKRTY ESGSESGDSD 
      1460       1470       1480       1490       1500
ESESKSEQRT KRQPKPTYKK KQNDLQKRKG EIEEDLKPNG VLSRSAKERS 
      1510       1520       1530       1540       1550
KLKLQSNSNT GIPRSVLKDW RKVKKLKQTG ESFLQDDSCC EIGPNLQKCR 
      1560       1570       1580       1590       1600
ECRLIRSKKG EEPAHSPVFC RFYYFRRLSF SKNGVVRIDG FSSPDQYDDE 
      1610       1620       1630       1640       1650
AMSLWTHENF EDDELDIETS KYILDIIGDK FCQLVTSEKT ALSWVKKDAK 
      1660       1670       1680       1690       1700
IAWKRAVRGV REMCDACEAT LFNIHWVCQK CGFVVCLDCY KAKERKSSRD 
      1710       1720       1730       1740       1750
KELYAWMKCV KGQPHDHKHL MPTQIIPGSV LTDLLDAMHT LREKYGIKSH 
      1760       1770       1780       1790       1800
CHCTNKQNLQ VGNFPTMNGV SQVLQNVLNH SNKISLCMPE SQQQNTPPKS 
      1810       1820       1830       1840       1850
EKNGGSSPES DVGTDNKLTP PESQSPLHWL ADLAEQKARE EKKENKELTL 
      1860       1870       1880       1890       1900
ENQIKEEREQ DNSESPNGRT SPLVSQNNEQ GSTLRDLLTT TAGKLRVGST 
      1910       1920       1930       1940       1950
DAGIAFAPVY SMGAPSSKSG RTMPNILDDI IASVVENKIP PSKTSKINVK 
      1960       1970       1980       1990       2000
PELKEEPEES IISAVDENNK LYSDIPHSWI CEKHILWLKD YKNSSNWKLF 
      2010       2020       2030       2040       2050
KECWKQGQPA VVSGVHKKMN ISLWKAESIS LDFGDHQADL LNCKDSIISN 
      2060       2070       2080       2090       2100
ANVKEFWDGF EEVSKRQKNK SGETVVLKLK DWPSGEDFKT MMPARYEDLL 
      2110       2120       2130       2140       2150
KSLPLPEYCN PEGKFNLASH LPGFFVRPDL GPRLCSAYGV VAAKDHDIGT 
      2160       2170       2180       2190       2200
TNLHIEVSDV VNILVYVGIA KGNGILSKAG ILKKFEEEDL DDILRKRLKD 
      2210       2220       2230       2240       2250
SSEIPGALWH IYAGKDVDKI REFLQKISKE QGLEVLPEHD PIRDQSWYVN 
      2260       2270       2280       2290       2300
KKLRQRLLEE YGVRTCTLIQ FLGDAIVLPA GALHQVQNFH SCIQVTEDFV 
      2310       2320       2330       2340       2350
SPEHLVESFH LTQELRLLKE EINYDDKLQV KNILYHAVKE MVRALKIHED 

EVEDMEEN

Note: May function as a tumor suppressor, reduced expression in breast cancer tumors.Curated

Show »

Length:2,358

Mass (Da):263,157

Checksum:ⁱ6005F440A38FC096

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1W2PNZ9	A0A1W2PNZ9_HUMAN	Probable JmjC domain-containing his... Probable JmjC domain-containing histone demethylation protein 2C	JMJD1C	2,358	Annotation score:
H7BXU7	H7BXU7_HUMAN	Probable JmjC domain-containing his... Probable JmjC domain-containing histone demethylation protein 2C	JMJD1C	956	Annotation score:

Sequence cautionⁱ

The sequence AAC41741 differs from that shown. Reason: Frameshift.Curated

The sequence CAD97921 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	488	T → A in CAD97921 (PubMed:17974005).Curated	1
Sequence conflictⁱ	779	T → A in CAD97921 (PubMed:17974005).Curated	1
Sequence conflictⁱ	783	T → P in CAD97921 (PubMed:17974005).Curated	1
Sequence conflictⁱ	2093	S → A in AAC41741 (PubMed:7776974).Curated	1
Sequence conflictⁱ	2148	Missing in BAA92618 (PubMed:10718198).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049654	272	A → T. Corresponds to variant dbSNP:rs34798625EnsemblClinVar.	1
Natural variantⁱVAR_049655	394	E → D. Corresponds to variant dbSNP:rs35380596Ensembl.	1
Natural variantⁱVAR_049656	464	S → T1 PublicationCorresponds to variant dbSNP:rs10761725Ensembl.	1
Natural variantⁱVAR_061277	591	M → V. Corresponds to variant dbSNP:rs41274072EnsemblClinVar.	1
Natural variantⁱVAR_049657	1393	N → Y. Corresponds to variant dbSNP:rs9703886Ensembl.	1
Natural variantⁱVAR_049658	2400	D → E. Corresponds to variant dbSNP:rs34491125EnsemblClinVar.	1
Natural variantⁱVAR_049659	2535	E → D1 PublicationCorresponds to variant dbSNP:rs1935Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_018303	1 – 219	Missing in isoform 2. 1 PublicationAdd BLAST	219
Alternative sequenceⁱVSP_043909	1 – 182	Missing in isoform 3. 1 PublicationAdd BLAST	182
Alternative sequenceⁱVSP_018304	1692 – 1699	TGIPRSVL → SCHLVKTE in isoform 2. 1 Publication	8
Alternative sequenceⁱVSP_018305	1700 – 2540	Missing in isoform 2. 1 PublicationAdd BLAST	841

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF068222 mRNA Translation: ABK64187.1 BX537954 mRNA Translation: CAD97921.1 Frameshift. AC022022 Genomic DNA No translation available. AL590502 Genomic DNA No translation available. AL607128 Genomic DNA No translation available. AL713895 Genomic DNA No translation available. AK027280 mRNA No translation available. AL831917 mRNA Translation: CAD38578.1 AB037801 mRNA Translation: BAA92618.1 L40411 mRNA Translation: AAC41741.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41532.1 [Q15652-1] CCDS60538.1 [Q15652-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001269877.1, NM_001282948.1 [Q15652-3] NP_001305082.1, NM_001318153.1 NP_001305083.1, NM_001318154.1 [Q15652-3] NP_001309181.1, NM_001322252.1 NP_001309183.1, NM_001322254.1 NP_001309187.1, NM_001322258.1 NP_116165.1, NM_032776.2 [Q15652-1] XP_016871386.1, XM_017015897.1 [Q15652-3] XP_016871387.1, XM_017015898.1 [Q15652-3]

Genome annotation databases

Ensemblⁱ	ENST00000399262; ENSP00000382204; ENSG00000171988 [Q15652-1] ENST00000542921; ENSP00000444682; ENSG00000171988 [Q15652-3]
GeneIDⁱ	221037
KEGGⁱ	hsa:221037
UCSC genome browser More...UCSCⁱ	uc001jmn.5, human [Q15652-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15652	Isoform 3 of Probable JmjC domain-containing histone demethylation protein 2C		HUMAN		2358	UniRef90_Q15652
Jumonji domain containing 1C		MACFA		2605
Jumonji domain containing 1C		PANPA		2540
Jumonji domain containing 1C		PANTR		2540
JMJD1C isoform 2		PONAB		2540
+149

Protein	Similar proteins		Species	Score	Length	Source
Q15652	Isoform 3 of Probable JmjC domain-containing histone demethylation protein 2C		HUMAN		2358	UniRef50_Q15652
Jumonji domain containing 1C		MACFA		2605
JMJD1C isoform 2		PONAB		2540
JmjC domain-containing protein		CALJA		2540
Jumonji domain containing 1C		PANTR		2540
+189
Q15652-2	JHD2C protein (Fragment)		blackcap		1761	UniRef50_Q15652-2
JHD2C protein (Fragment)		marbled wood quail		1770
JHD2C protein (Fragment)		Mesembrinibis cayennensis		1774
JHD2C protein (Fragment)		CORCN		1776
JHD2C protein (Fragment)		BALRX		1774
+72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF068222 mRNA Translation: ABK64187.1 BX537954 mRNA Translation: CAD97921.1 Frameshift. AC022022 Genomic DNA No translation available. AL590502 Genomic DNA No translation available. AL607128 Genomic DNA No translation available. AL713895 Genomic DNA No translation available. AK027280 mRNA No translation available. AL831917 mRNA Translation: CAD38578.1 AB037801 mRNA Translation: BAA92618.1 L40411 mRNA Translation: AAC41741.1 Frameshift.
CCDSⁱ	CCDS41532.1 [Q15652-1] CCDS60538.1 [Q15652-3]
RefSeqⁱ	NP_001269877.1, NM_001282948.1 [Q15652-3] NP_001305082.1, NM_001318153.1 NP_001305083.1, NM_001318154.1 [Q15652-3] NP_001309181.1, NM_001322252.1 NP_001309183.1, NM_001322254.1 NP_001309187.1, NM_001322258.1 NP_116165.1, NM_032776.2 [Q15652-1] XP_016871386.1, XM_017015897.1 [Q15652-3] XP_016871387.1, XM_017015898.1 [Q15652-3]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2YPD	X-ray	2.10	A/B	2157-2540	[»]
	5FZO	X-ray	1.84	A/B	2157-2500	[»]
SMRⁱ	Q15652
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	128677, 42 interactors
DIPⁱ	DIP-38114N
IntActⁱ	Q15652, 16 interactors
MINTⁱ	Q15652
STRINGⁱ	9606.ENSP00000382204

Chemistry databases

BindingDBⁱ	Q15652
ChEMBLⁱ	CHEMBL3792271

PTM databases

GlyGenⁱ	Q15652, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetⁱ	Q15652
PhosphoSitePlusⁱ	Q15652

Genetic variation databases

BioMutaⁱ	JMJD1C
DMDMⁱ	85541650

Proteomic databases

EPDⁱ	Q15652
jPOSTⁱ	Q15652
MassIVEⁱ	Q15652
MaxQBⁱ	Q15652
PaxDbⁱ	Q15652
PeptideAtlasⁱ	Q15652
PRIDEⁱ	Q15652
ProteomicsDBⁱ	60691 [Q15652-1] 60692 [Q15652-2] 60693 [Q15652-3]

Protocols and materials databases

Antibodypediaⁱ	28318, 134 antibodies
The DNASU plasmid repository More...DNASUⁱ	221037

Genome annotation databases

Ensemblⁱ	ENST00000399262; ENSP00000382204; ENSG00000171988 [Q15652-1] ENST00000542921; ENSP00000444682; ENSG00000171988 [Q15652-3]
GeneIDⁱ	221037
KEGGⁱ	hsa:221037
UCSCⁱ	uc001jmn.5, human [Q15652-1]

Organism-specific databases

CTDⁱ	221037
DisGeNETⁱ	221037
GeneCardsⁱ	JMJD1C
HGNCⁱ	HGNC:12313, JMJD1C
HPAⁱ	ENSG00000171988, Low tissue specificity
MalaCardsⁱ	JMJD1C
MIMⁱ	604503, gene
neXtProtⁱ	NX_Q15652
OpenTargetsⁱ	ENSG00000171988
Orphanetⁱ	567, 22q11.2 deletion syndrome 91352, Germinoma of the central nervous system
PharmGKBⁱ	PA128394767
VEuPathDBⁱ	HostDB:ENSG00000171988.17
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1356, Eukaryota
GeneTreeⁱ	ENSGT00940000158210
HOGENOMⁱ	CLU_228251_0_0_1
InParanoidⁱ	Q15652
OMAⁱ	FMSSLNV
OrthoDBⁱ	1185631at2759
PhylomeDBⁱ	Q15652
TreeFamⁱ	TF324723

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000171988-MONOMER
BRENDAⁱ	1.14.11.65, 2681
PathwayCommonsⁱ	Q15652
Reactomeⁱ	R-HSA-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

BioGRID-ORCSⁱ	221037, 12 hits in 998 CRISPR screens
ChiTaRSⁱ	JMJD1C, human
GenomeRNAiⁱ	221037
Pharosⁱ	Q15652, Tbio
Protein Ontology More...PROⁱ	PR:Q15652
RNActⁱ	Q15652, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171988, Expressed in intestine and 241 other tissues
ExpressionAtlasⁱ	Q15652, baseline and differential
Genevisibleⁱ	Q15652, HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003347, JmjC_dom
Pfamⁱ	View protein in Pfam PF02373, JmjC, 1 hit
SMARTⁱ	View protein in SMART SM00558, JmjC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51184, JMJC, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	JHD2C_HUMAN
Accessionⁱ	Q15652Primary (citable) accession number: Q15652 Secondary accession number(s): A0T124 Q9P2G7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 10, 2006
	Last modified:	June 2, 2021
	This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q15652 (JHD2C_HUMAN)

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Probable JmjC domain-containing histone demethylation protein 2C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q15652

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ