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Protein

High mobility group nucleosome-binding domain-containing protein 3

Gene

HMGN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).By similarity

GO - Molecular functioni

  • nucleosomal DNA binding Source: InterPro
  • thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding

Enzyme and pathway databases

SignaLinkiQ15651

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 3
Alternative name(s):
Thyroid receptor-interacting protein 7
Short name:
TR-interacting protein 7
Short name:
TRIP-7
Gene namesi
Name:HMGN3
Synonyms:TRIP7
ORF Names:PNAS-24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118418.14
HGNCiHGNC:12312 HMGN3
MIMi604502 gene
neXtProtiNX_Q15651

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118418
PharmGKBiPA36990

Polymorphism and mutation databases

BioMutaiHMGN3
DMDMi23831169

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325741 – 99High mobility group nucleosome-binding domain-containing protein 3Add BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei10PhosphothreonineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15651
MaxQBiQ15651
PaxDbiQ15651
PeptideAtlasiQ15651
PRIDEiQ15651
ProteomicsDBi60689
60690 [Q15651-2]
TopDownProteomicsiQ15651-1 [Q15651-1]
Q15651-2 [Q15651-2]

PTM databases

iPTMnetiQ15651
PhosphoSitePlusiQ15651

Expressioni

Tissue specificityi

Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.2 Publications

Inductioni

By estrogen.

Gene expression databases

BgeeiENSG00000118418 Expressed in 235 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_HMGN3
ExpressionAtlasiQ15651 baseline and differential
GenevisibleiQ15651 HS

Organism-specific databases

HPAiCAB018370
HPA027971
HPA063572

Interactioni

Subunit structurei

Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence of thyroid hormone for its interaction. Interacts with nucleosomes.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114734, 10 interactors
IntActiQ15651, 11 interactors
STRINGi9606.ENSP00000341267

Structurei

3D structure databases

ProteinModelPortaliQ15651
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J0Z7 Eukaryota
ENOG410YTHP LUCA
GeneTreeiENSGT00730000111287
HOGENOMiHOG000116395
HOVERGENiHBG073479
InParanoidiQ15651
KOiK11301
PhylomeDBiQ15651

Family and domain databases

InterProiView protein in InterPro
IPR031073 HMGN3
IPR000079 HMGN_fam
PANTHERiPTHR23087:SF2 PTHR23087:SF2, 1 hit
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15651-1) [UniParc]FASTAAdd to basket
Also known as: HMGN3a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKRKSPENT EGKDGSKVTK QEPTRRSARL SAKPAPPKPE PKPRKTSAKK
60 70 80 90
EPGAKISRGA KGKKEEKQEA GKEGTAPSEN GETKAEEAQK TESVDNEGE
Length:99
Mass (Da):10,666
Last modified:October 10, 2002 - v2
Checksum:iACC44835523B9C21
GO
Isoform 2 (identifier: Q15651-2) [UniParc]FASTAAdd to basket
Also known as: HMGN3b

The sequence of this isoform differs from the canonical sequence as follows:
     76-77: AP → EN
     78-99: Missing.

Show »
Length:77
Mass (Da):8,378
Checksum:iB2650E1912B8828A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZE9A0A087WZE9_HUMAN
High mobility group nucleosome-bind...
HMGN3
130Annotation score:

Sequence cautioni

The sequence AAA73877 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01790776 – 77AP → EN in isoform 2. 3 Publications2
Alternative sequenceiVSP_01790878 – 99Missing in isoform 2. 3 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40357 mRNA Translation: AAA73877.1 Different initiation.
AF401520 mRNA Translation: AAK92012.1
AF274949 mRNA Translation: AAK07526.1
AY043282 mRNA Translation: AAK85736.1
AK315391 mRNA Translation: BAG37784.1
AL355796 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48711.1
BC009529 mRNA Translation: AAH09529.1
BK000003 mRNA Translation: DAA00392.1
BK000006 mRNA Translation: DAA00395.1
BX648085 Transcribed RNA Translation: CAI46267.1
CCDSiCCDS4988.1 [Q15651-1]
CCDS4989.1 [Q15651-2]
RefSeqiNP_001188291.1, NM_001201362.1
NP_001188292.1, NM_001201363.1
NP_001305813.1, NM_001318884.1
NP_001305814.1, NM_001318885.1
NP_001305815.1, NM_001318886.1
NP_001305816.1, NM_001318887.1
NP_001305817.1, NM_001318888.1
NP_004233.1, NM_004242.3 [Q15651-1]
NP_620058.1, NM_138730.2 [Q15651-2]
UniGeneiHs.77558

Genome annotation databases

EnsembliENST00000275036; ENSP00000275036; ENSG00000118418 [Q15651-2]
ENST00000344726; ENSP00000341267; ENSG00000118418 [Q15651-1]
GeneIDi9324
KEGGihsa:9324
UCSCiuc003pis.4 human [Q15651-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40357 mRNA Translation: AAA73877.1 Different initiation.
AF401520 mRNA Translation: AAK92012.1
AF274949 mRNA Translation: AAK07526.1
AY043282 mRNA Translation: AAK85736.1
AK315391 mRNA Translation: BAG37784.1
AL355796 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48711.1
BC009529 mRNA Translation: AAH09529.1
BK000003 mRNA Translation: DAA00392.1
BK000006 mRNA Translation: DAA00395.1
BX648085 Transcribed RNA Translation: CAI46267.1
CCDSiCCDS4988.1 [Q15651-1]
CCDS4989.1 [Q15651-2]
RefSeqiNP_001188291.1, NM_001201362.1
NP_001188292.1, NM_001201363.1
NP_001305813.1, NM_001318884.1
NP_001305814.1, NM_001318885.1
NP_001305815.1, NM_001318886.1
NP_001305816.1, NM_001318887.1
NP_001305817.1, NM_001318888.1
NP_004233.1, NM_004242.3 [Q15651-1]
NP_620058.1, NM_138730.2 [Q15651-2]
UniGeneiHs.77558

3D structure databases

ProteinModelPortaliQ15651
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114734, 10 interactors
IntActiQ15651, 11 interactors
STRINGi9606.ENSP00000341267

PTM databases

iPTMnetiQ15651
PhosphoSitePlusiQ15651

Polymorphism and mutation databases

BioMutaiHMGN3
DMDMi23831169

Proteomic databases

EPDiQ15651
MaxQBiQ15651
PaxDbiQ15651
PeptideAtlasiQ15651
PRIDEiQ15651
ProteomicsDBi60689
60690 [Q15651-2]
TopDownProteomicsiQ15651-1 [Q15651-1]
Q15651-2 [Q15651-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275036; ENSP00000275036; ENSG00000118418 [Q15651-2]
ENST00000344726; ENSP00000341267; ENSG00000118418 [Q15651-1]
GeneIDi9324
KEGGihsa:9324
UCSCiuc003pis.4 human [Q15651-1]

Organism-specific databases

CTDi9324
EuPathDBiHostDB:ENSG00000118418.14
GeneCardsiHMGN3
HGNCiHGNC:12312 HMGN3
HPAiCAB018370
HPA027971
HPA063572
MIMi604502 gene
neXtProtiNX_Q15651
OpenTargetsiENSG00000118418
PharmGKBiPA36990
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0Z7 Eukaryota
ENOG410YTHP LUCA
GeneTreeiENSGT00730000111287
HOGENOMiHOG000116395
HOVERGENiHBG073479
InParanoidiQ15651
KOiK11301
PhylomeDBiQ15651

Enzyme and pathway databases

SignaLinkiQ15651

Miscellaneous databases

ChiTaRSiHMGN3 human
GeneWikiiHMGN3
GenomeRNAii9324
PROiPR:Q15651
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118418 Expressed in 235 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_HMGN3
ExpressionAtlasiQ15651 baseline and differential
GenevisibleiQ15651 HS

Family and domain databases

InterProiView protein in InterPro
IPR031073 HMGN3
IPR000079 HMGN_fam
PANTHERiPTHR23087:SF2 PTHR23087:SF2, 1 hit
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN3_HUMAN
AccessioniPrimary (citable) accession number: Q15651
Secondary accession number(s): B2RD37
, Q5HYD3, Q7RTT0, Q969M5, Q9BZT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2002
Last modified: September 12, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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