UniProtKB - Q15650 (TRIP4_HUMAN)
Activating signal cointegrator 1
TRIP4
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 171 – 187 | C4-typeAdd BLAST | 17 |
GO - Molecular functioni
- estrogen receptor binding Source: UniProtKB
- histone acetyltransferase binding Source: UniProtKB
- nuclear receptor binding Source: UniProtKB
- protease binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- ubiquitin-like protein ligase binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- intracellular estrogen receptor signaling pathway Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of myoblast differentiation Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- toxin transport Source: Ensembl
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q15650 |
Names & Taxonomyi
Protein namesi | Recommended name: Activating signal cointegrator 11 PublicationShort name: ASC-11 Publication Alternative name(s): Thyroid receptor-interacting protein 41 Publication Short name: TR-interacting protein 41 Publication Short name: TRIP-41 Publication |
Gene namesi | Name:TRIP4Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12310, TRIP4 |
MIMi | 604501, gene |
neXtProti | NX_Q15650 |
VEuPathDBi | HostDB:ENSG00000103671.9 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
Nucleus
- Nucleus 4 Publications
Cytosol
- cytosol 2 Publications
Note: Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783).2 Publications
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: UniProtKB-SubCell
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- activating signal cointegrator 1 complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- neuromuscular junction Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Spinal muscular atrophy with congenital bone fractures 1 (SMABF1)1 Publication
Muscular dystrophy, congenital, Davignon-Chauveau type (MDCDC)1 Publication
Keywords - Diseasei
Congenital muscular dystrophy, NeurodegenerationOrganism-specific databases
DisGeNETi | 9325 |
MalaCardsi | TRIP4 |
MIMi | 616866, phenotype 617066, phenotype |
OpenTargetsi | ENSG00000103671 |
Orphaneti | 486815, Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome 486811, Prenatal-onset spinal muscular atrophy with congenital bone fractures |
PharmGKBi | PA36988 |
Miscellaneous databases
Pharosi | Q15650, Tbio |
Genetic variation databases
BioMutai | TRIP4 |
DMDMi | 116242828 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000065631 | 2 – 581 | Activating signal cointegrator 1Add BLAST | 580 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 276 | PhosphoserineCombined sources | 1 | |
Modified residuei | 289 | PhosphotyrosineBy similarity | 1 | |
Cross-linki | 324 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)1 Publication | ||
Cross-linki | 325 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)1 Publication | ||
Cross-linki | 334 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)1 Publication | ||
Modified residuei | 341 | PhosphoserineCombined sources | 1 | |
Cross-linki | 367 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)1 Publication |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q15650 |
jPOSTi | Q15650 |
MassIVEi | Q15650 |
MaxQBi | Q15650 |
PaxDbi | Q15650 |
PeptideAtlasi | Q15650 |
PRIDEi | Q15650 |
ProteomicsDBi | 60688 |
PTM databases
iPTMneti | Q15650 |
PhosphoSitePlusi | Q15650 |
SwissPalmi | Q15650 |
Expressioni
Gene expression databases
Bgeei | ENSG00000103671, Expressed in amniotic fluid and 232 other tissues |
ExpressionAtlasi | Q15650, baseline and differential |
Genevisiblei | Q15650, HS |
Organism-specific databases
HPAi | ENSG00000103671, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the thyroid hormone receptor/TR (via the ligand-binding domain); this interaction requires the presence of thyroid hormone (PubMed:10454579).
Interacts with the androgen receptor/AR; in an androgen, testosterone and dihydrotestosterone-dependent manner (PubMed:12390891).
Interacts with ESR1 (estrogen ligand-bound); competes with UFSP2 (PubMed:10454579, PubMed:25219498).
Interacts with UFSP2; competes with ligand-bound ESR1 (PubMed:25219498).
Interacts with DDRGK1 and UFL1; the interaction with DDRGK1 is direct (PubMed:25219498).
Interacts with NCOA1 (PubMed:25219498).
Interacts with EP300 (PubMed:25219498). Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347).
Interacts with NEK6 (PubMed:20873783).
Interacts with CSRP1 (PubMed:26924529).
Interacts with ZCCHC4 (PubMed:31799605).
7 PublicationsGO - Molecular functioni
- estrogen receptor binding Source: UniProtKB
- histone acetyltransferase binding Source: UniProtKB
- nuclear receptor binding Source: UniProtKB
- protease binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- ubiquitin-like protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114735, 170 interactors |
CORUMi | Q15650 |
IntActi | Q15650, 17 interactors |
STRINGi | 9606.ENSP00000261884 |
Miscellaneous databases
RNActi | Q15650, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q15650 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15650 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 200 – 300 | Mediates interaction with DDRGK11 PublicationAdd BLAST | 101 | |
Regioni | 300 – 400 | Mediates interaction with UFL11 PublicationAdd BLAST | 101 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 171 – 187 | C4-typeAdd BLAST | 17 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2845, Eukaryota |
GeneTreei | ENSGT00390000005300 |
HOGENOMi | CLU_025737_1_0_1 |
InParanoidi | Q15650 |
OMAi | DDEADYF |
OrthoDBi | 1132270at2759 |
PhylomeDBi | Q15650 |
TreeFami | TF314842 |
Family and domain databases
InterProi | View protein in InterPro IPR007374, ASCH_domain IPR015947, PUA-like_sf IPR039128, TRIP4-like IPR009349, Znf_C2HC5 |
PANTHERi | PTHR12963, PTHR12963, 1 hit |
Pfami | View protein in Pfam PF04266, ASCH, 1 hit PF06221, zf-C2HC5, 1 hit |
SMARTi | View protein in SMART SM01022, ASCH, 1 hit |
SUPFAMi | SSF88697, SSF88697, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAVAGAVSGE PLVHWCTQQL RKTFGLDVSE EIIQYVLSIE SAEEIREYVT
60 70 80 90 100
DLLQGNEGKK GQFIEELITK WQKNDQELIS DPLQQCFKKD EILDGQKSGD
110 120 130 140 150
HLKRGRKKGR NRQEVPAFTE PDTTAEVKTP FDLAKAQENS NSVKKKTKFV
160 170 180 190 200
NLYTREGQDR LAVLLPGRHP CDCLGQKHKL INNCLICGRI VCEQEGSGPC
210 220 230 240 250
LFCGTLVCTH EEQDILQRDS NKSQKLLKKL MSGVENSGKV DISTKDLLPH
260 270 280 290 300
QELRIKSGLE KAIKHKDKLL EFDRTSIRRT QVIDDESDYF ASDSNQWLSK
310 320 330 340 350
LERETLQKRE EELRELRHAS RLSKKVTIDF AGRKILEEEN SLAEYHSRLD
360 370 380 390 400
ETIQAIANGT LNQPLTKLDR SSEEPLGVLV NPNMYQSPPQ WVDHTGAASQ
410 420 430 440 450
KKAFRSSGFG LEFNSFQHQL RIQDQEFQEG FDGGWCLSVH QPWASLLVRG
460 470 480 490 500
IKRVEGRSWY TPHRGRLWIA ATAKKPSPQE VSELQATYRL LRGKDVEFPN
510 520 530 540 550
DYPSGCLLGC VDLIDCLSQK QFKEQFPDIS QESDSPFVFI CKNPQEMVVK
560 570 580
FPIKGNPKIW KLDSKIHQGA KKGLMKQNKA V
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YL91 | H0YL91_HUMAN | Activating signal cointegrator 1 | TRIP4 | 368 | Annotation score: | ||
H0YKD9 | H0YKD9_HUMAN | Activating signal cointegrator 1 | TRIP4 | 111 | Annotation score: | ||
H0YLN7 | H0YLN7_HUMAN | Activating signal cointegrator 1 | TRIP4 | 126 | Annotation score: | ||
H3BMU9 | H3BMU9_HUMAN | Activating signal cointegrator 1 | TRIP4 | 61 | Annotation score: | ||
H0YK63 | H0YK63_HUMAN | Activating signal cointegrator 1 | TRIP4 | 43 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 157 | G → R in AAF01278 (PubMed:10454579).Curated | 1 | |
Sequence conflicti | 157 | G → R in AAC41738 (PubMed:7776974).Curated | 1 | |
Sequence conflicti | 164 | L → A in AAF01278 (PubMed:10454579).Curated | 1 | |
Sequence conflicti | 475 | K → N in AAC41738 (PubMed:7776974).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF168418 mRNA Translation: AAF01278.1 AK314319 mRNA Translation: BAG36967.1 CH471082 Genomic DNA Translation: EAW77685.1 BC012448 mRNA Translation: AAH12448.1 L40371 mRNA Translation: AAC41738.1 Frameshift. |
CCDSi | CCDS10194.1 |
RefSeqi | NP_001308853.1, NM_001321924.1 NP_057297.2, NM_016213.4 |
Genome annotation databases
Ensembli | ENST00000261884; ENSP00000261884; ENSG00000103671 |
GeneIDi | 9325 |
KEGGi | hsa:9325 |
UCSCi | uc002anm.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF168418 mRNA Translation: AAF01278.1 AK314319 mRNA Translation: BAG36967.1 CH471082 Genomic DNA Translation: EAW77685.1 BC012448 mRNA Translation: AAH12448.1 L40371 mRNA Translation: AAC41738.1 Frameshift. |
CCDSi | CCDS10194.1 |
RefSeqi | NP_001308853.1, NM_001321924.1 NP_057297.2, NM_016213.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E5O | NMR | - | A | 435-581 | [»] | |
SMRi | Q15650 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114735, 170 interactors |
CORUMi | Q15650 |
IntActi | Q15650, 17 interactors |
STRINGi | 9606.ENSP00000261884 |
PTM databases
iPTMneti | Q15650 |
PhosphoSitePlusi | Q15650 |
SwissPalmi | Q15650 |
Genetic variation databases
BioMutai | TRIP4 |
DMDMi | 116242828 |
Proteomic databases
EPDi | Q15650 |
jPOSTi | Q15650 |
MassIVEi | Q15650 |
MaxQBi | Q15650 |
PaxDbi | Q15650 |
PeptideAtlasi | Q15650 |
PRIDEi | Q15650 |
ProteomicsDBi | 60688 |
Protocols and materials databases
Antibodypediai | 1761, 269 antibodies |
DNASUi | 9325 |
Genome annotation databases
Ensembli | ENST00000261884; ENSP00000261884; ENSG00000103671 |
GeneIDi | 9325 |
KEGGi | hsa:9325 |
UCSCi | uc002anm.3, human |
Organism-specific databases
CTDi | 9325 |
DisGeNETi | 9325 |
GeneCardsi | TRIP4 |
HGNCi | HGNC:12310, TRIP4 |
HPAi | ENSG00000103671, Low tissue specificity |
MalaCardsi | TRIP4 |
MIMi | 604501, gene 616866, phenotype 617066, phenotype |
neXtProti | NX_Q15650 |
OpenTargetsi | ENSG00000103671 |
Orphaneti | 486815, Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome 486811, Prenatal-onset spinal muscular atrophy with congenital bone fractures |
PharmGKBi | PA36988 |
VEuPathDBi | HostDB:ENSG00000103671.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2845, Eukaryota |
GeneTreei | ENSGT00390000005300 |
HOGENOMi | CLU_025737_1_0_1 |
InParanoidi | Q15650 |
OMAi | DDEADYF |
OrthoDBi | 1132270at2759 |
PhylomeDBi | Q15650 |
TreeFami | TF314842 |
Enzyme and pathway databases
PathwayCommonsi | Q15650 |
Miscellaneous databases
BioGRID-ORCSi | 9325, 11 hits in 880 CRISPR screens |
ChiTaRSi | TRIP4, human |
EvolutionaryTracei | Q15650 |
GeneWikii | TRIP4 |
GenomeRNAii | 9325 |
Pharosi | Q15650, Tbio |
PROi | PR:Q15650 |
RNActi | Q15650, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103671, Expressed in amniotic fluid and 232 other tissues |
ExpressionAtlasi | Q15650, baseline and differential |
Genevisiblei | Q15650, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007374, ASCH_domain IPR015947, PUA-like_sf IPR039128, TRIP4-like IPR009349, Znf_C2HC5 |
PANTHERi | PTHR12963, PTHR12963, 1 hit |
Pfami | View protein in Pfam PF04266, ASCH, 1 hit PF06221, zf-C2HC5, 1 hit |
SMARTi | View protein in SMART SM01022, ASCH, 1 hit |
SUPFAMi | SSF88697, SSF88697, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRIP4_HUMAN | |
Accessioni | Q15650Primary (citable) accession number: Q15650 Secondary accession number(s): B2RAS0, Q96ED7, Q9UKH0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 178 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references