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Protein

Activating signal cointegrator 1

Gene

TRIP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity).By similarity4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 187C4-typeAdd BLAST17

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB
  • histone acetyltransferase binding Source: UniProtKB
  • nuclear receptor binding Source: UniProtKB
  • protease binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB
  • ubiquitin-like protein ligase binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Activating signal cointegrator 11 Publication
Short name:
ASC-11 Publication
Alternative name(s):
Thyroid receptor-interacting protein 41 Publication
Short name:
TR-interacting protein 41 Publication
Short name:
TRIP-41 Publication
Gene namesi
Name:TRIP4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000103671.9
HGNCiHGNC:12310 TRIP4
MIMi604501 gene
neXtProtiNX_Q15650

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Spinal muscular atrophy with congenital bone fractures 1 (SMABF1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neuromuscular disorder characterized by prenatal-onset spinal muscular atrophy, multiple congenital contractures consistent with arthrogryposis multiplex congenita, respiratory distress, and congenital bone fractures.
See also OMIM:616866
Muscular dystrophy, congenital, Davignon-Chauveau type (MDCDC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, severe congenital muscular dystrophy characterized by neonatal onset of muscle weakness predominantly involving axial muscles, life-threatening respiratory failure, skin abnormalities and joint hyperlaxity without contractures. Muscle biopsies show multi-minicores, caps and dystrophic lesions.
See also OMIM:617066

Keywords - Diseasei

Congenital muscular dystrophy, Neurodegeneration

Organism-specific databases

DisGeNETi9325
MalaCardsiTRIP4
MIMi616866 phenotype
617066 phenotype
OpenTargetsiENSG00000103671
Orphaneti486815 Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome
486811 Prenatal-onset spinal muscular atrophy with congenital bone fractures
PharmGKBiPA36988

Polymorphism and mutation databases

BioMutaiTRIP4
DMDMi116242828

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000656312 – 581Activating signal cointegrator 1Add BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei289PhosphotyrosineBy similarity1
Cross-linki324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)1 Publication
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)1 Publication
Cross-linki334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)1 Publication
Modified residuei341PhosphoserineCombined sources1
Cross-linki367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)1 Publication

Post-translational modificationi

Phosphorylated by NEK6.1 Publication
Polyufmylated by the UFM1-conjugating system composed of the enzymes UBA5, UFC1 and UFL1. Deufmylated by the protease UFSP2. Ufmylation of TRIP4 is promoted by ligand-bound nuclear receptors that compete with UFSP2 for interaction with TRIP4. Nuclear receptors-induced ufmylation promotes the recruitment of additional transcriptional coactivators like EP300 and NCOA1 and therefore the assembly of a coactivator complex facilitating nuclear receptor-mediated transcription.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15650
MaxQBiQ15650
PaxDbiQ15650
PeptideAtlasiQ15650
PRIDEiQ15650
ProteomicsDBi60688

PTM databases

iPTMnetiQ15650
PhosphoSitePlusiQ15650

Expressioni

Gene expression databases

BgeeiENSG00000103671 Expressed in 220 organ(s), highest expression level in amniotic fluid
CleanExiHS_TRIP4
ExpressionAtlasiQ15650 baseline and differential
GenevisibleiQ15650 HS

Organism-specific databases

HPAiHPA016605
HPA050666

Interactioni

Subunit structurei

Interacts with the thyroid hormone receptor/TR (via the ligand-binding domain); this interaction requires the presence of thyroid hormone (PubMed:10454579). Interacts with the androgen receptor/AR; in an androgen, testosterone and dihydrotestosterone-dependent manner (PubMed:12390891). Interacts with ESR1 (estrogen ligand-bound); competes with UFSP2 (PubMed:10454579, PubMed:25219498). Interacts with UFSP2; competes with ligand-bound ESR1 (PubMed:25219498). Interacts with DDRGK1 and UFL1; the interaction with DDRGK1 is direct (PubMed:25219498). Interacts with NCOA1 (PubMed:25219498). Interacts with EP300 (PubMed:25219498). Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Interacts with NEK6 (PubMed:20873783). Interacts with CSRP1 (PubMed:26924529).6 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114735, 51 interactors
CORUMiQ15650
IntActiQ15650, 11 interactors
STRINGi9606.ENSP00000261884

Structurei

Secondary structure

1581
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15650
SMRiQ15650
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15650

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni200 – 300Mediates interaction with DDRGK11 PublicationAdd BLAST101
Regioni300 – 400Mediates interaction with UFL11 PublicationAdd BLAST101

Domaini

The C4-type zinc finger mediates a competitive interaction with UFSP2 and ligand-bound nuclear receptors. It also mediates interaction with the transcriptional coactivators and the basal transcription machinery.3 Publications

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 187C4-typeAdd BLAST17

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2845 Eukaryota
ENOG410XTTP LUCA
GeneTreeiENSGT00390000005300
HOGENOMiHOG000006873
HOVERGENiHBG061618
InParanoidiQ15650
OMAiKGKHKIW
OrthoDBiEOG091G096V
PhylomeDBiQ15650
TreeFamiTF314842

Family and domain databases

InterProiView protein in InterPro
IPR007374 ASCH_domain
IPR015947 PUA-like_sf
IPR039128 TRIP4-like
IPR009349 Znf_C2HC5
PANTHERiPTHR12963 PTHR12963, 1 hit
PfamiView protein in Pfam
PF04266 ASCH, 1 hit
PF06221 zf-C2HC5, 1 hit
SMARTiView protein in SMART
SM01022 ASCH, 1 hit
SUPFAMiSSF88697 SSF88697, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q15650-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVAGAVSGE PLVHWCTQQL RKTFGLDVSE EIIQYVLSIE SAEEIREYVT
60 70 80 90 100
DLLQGNEGKK GQFIEELITK WQKNDQELIS DPLQQCFKKD EILDGQKSGD
110 120 130 140 150
HLKRGRKKGR NRQEVPAFTE PDTTAEVKTP FDLAKAQENS NSVKKKTKFV
160 170 180 190 200
NLYTREGQDR LAVLLPGRHP CDCLGQKHKL INNCLICGRI VCEQEGSGPC
210 220 230 240 250
LFCGTLVCTH EEQDILQRDS NKSQKLLKKL MSGVENSGKV DISTKDLLPH
260 270 280 290 300
QELRIKSGLE KAIKHKDKLL EFDRTSIRRT QVIDDESDYF ASDSNQWLSK
310 320 330 340 350
LERETLQKRE EELRELRHAS RLSKKVTIDF AGRKILEEEN SLAEYHSRLD
360 370 380 390 400
ETIQAIANGT LNQPLTKLDR SSEEPLGVLV NPNMYQSPPQ WVDHTGAASQ
410 420 430 440 450
KKAFRSSGFG LEFNSFQHQL RIQDQEFQEG FDGGWCLSVH QPWASLLVRG
460 470 480 490 500
IKRVEGRSWY TPHRGRLWIA ATAKKPSPQE VSELQATYRL LRGKDVEFPN
510 520 530 540 550
DYPSGCLLGC VDLIDCLSQK QFKEQFPDIS QESDSPFVFI CKNPQEMVVK
560 570 580
FPIKGNPKIW KLDSKIHQGA KKGLMKQNKA V
Length:581
Mass (Da):66,146
Last modified:October 17, 2006 - v4
Checksum:iDADD3994533A808E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YL91H0YL91_HUMAN
Activating signal cointegrator 1
TRIP4
368Annotation score:
H0YLN7H0YLN7_HUMAN
Activating signal cointegrator 1
TRIP4
126Annotation score:
H0YKD9H0YKD9_HUMAN
Activating signal cointegrator 1
TRIP4
111Annotation score:
H0YK63H0YK63_HUMAN
Activating signal cointegrator 1
TRIP4
43Annotation score:
H3BMU9H3BMU9_HUMAN
Activating signal cointegrator 1
TRIP4
61Annotation score:

Sequence cautioni

The sequence AAC41738 differs from that shown. Reason: Frameshift at positions 391, 444 and 476.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157G → R in AAF01278 (PubMed:10454579).Curated1
Sequence conflicti157G → R in AAC41738 (PubMed:7776974).Curated1
Sequence conflicti164L → A in AAF01278 (PubMed:10454579).Curated1
Sequence conflicti475K → N in AAC41738 (PubMed:7776974).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168418 mRNA Translation: AAF01278.1
AK314319 mRNA Translation: BAG36967.1
CH471082 Genomic DNA Translation: EAW77685.1
BC012448 mRNA Translation: AAH12448.1
L40371 mRNA Translation: AAC41738.1 Frameshift.
CCDSiCCDS10194.1
RefSeqiNP_001308853.1, NM_001321924.1
NP_057297.2, NM_016213.4
UniGeneiHs.500340

Genome annotation databases

EnsembliENST00000261884; ENSP00000261884; ENSG00000103671
GeneIDi9325
KEGGihsa:9325
UCSCiuc002anm.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168418 mRNA Translation: AAF01278.1
AK314319 mRNA Translation: BAG36967.1
CH471082 Genomic DNA Translation: EAW77685.1
BC012448 mRNA Translation: AAH12448.1
L40371 mRNA Translation: AAC41738.1 Frameshift.
CCDSiCCDS10194.1
RefSeqiNP_001308853.1, NM_001321924.1
NP_057297.2, NM_016213.4
UniGeneiHs.500340

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E5ONMR-A435-581[»]
ProteinModelPortaliQ15650
SMRiQ15650
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114735, 51 interactors
CORUMiQ15650
IntActiQ15650, 11 interactors
STRINGi9606.ENSP00000261884

PTM databases

iPTMnetiQ15650
PhosphoSitePlusiQ15650

Polymorphism and mutation databases

BioMutaiTRIP4
DMDMi116242828

Proteomic databases

EPDiQ15650
MaxQBiQ15650
PaxDbiQ15650
PeptideAtlasiQ15650
PRIDEiQ15650
ProteomicsDBi60688

Protocols and materials databases

DNASUi9325
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261884; ENSP00000261884; ENSG00000103671
GeneIDi9325
KEGGihsa:9325
UCSCiuc002anm.3 human

Organism-specific databases

CTDi9325
DisGeNETi9325
EuPathDBiHostDB:ENSG00000103671.9
GeneCardsiTRIP4
HGNCiHGNC:12310 TRIP4
HPAiHPA016605
HPA050666
MalaCardsiTRIP4
MIMi604501 gene
616866 phenotype
617066 phenotype
neXtProtiNX_Q15650
OpenTargetsiENSG00000103671
Orphaneti486815 Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome
486811 Prenatal-onset spinal muscular atrophy with congenital bone fractures
PharmGKBiPA36988
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2845 Eukaryota
ENOG410XTTP LUCA
GeneTreeiENSGT00390000005300
HOGENOMiHOG000006873
HOVERGENiHBG061618
InParanoidiQ15650
OMAiKGKHKIW
OrthoDBiEOG091G096V
PhylomeDBiQ15650
TreeFamiTF314842

Miscellaneous databases

ChiTaRSiTRIP4 human
EvolutionaryTraceiQ15650
GeneWikiiTRIP4
GenomeRNAii9325
PROiPR:Q15650
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103671 Expressed in 220 organ(s), highest expression level in amniotic fluid
CleanExiHS_TRIP4
ExpressionAtlasiQ15650 baseline and differential
GenevisibleiQ15650 HS

Family and domain databases

InterProiView protein in InterPro
IPR007374 ASCH_domain
IPR015947 PUA-like_sf
IPR039128 TRIP4-like
IPR009349 Znf_C2HC5
PANTHERiPTHR12963 PTHR12963, 1 hit
PfamiView protein in Pfam
PF04266 ASCH, 1 hit
PF06221 zf-C2HC5, 1 hit
SMARTiView protein in SMART
SM01022 ASCH, 1 hit
SUPFAMiSSF88697 SSF88697, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRIP4_HUMAN
AccessioniPrimary (citable) accession number: Q15650
Secondary accession number(s): B2RAS0, Q96ED7, Q9UKH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 164 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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