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Protein

Zinc finger HIT domain-containing protein 3

Gene

ZNHIT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri11 – 42HIT-typePROSITE-ProRule annotationAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger HIT domain-containing protein 3
Alternative name(s):
HNF-4a coactivator
Thyroid hormone receptor interactor 3
Thyroid receptor-interacting protein 3
Short name:
TR-interacting protein 3
Short name:
TRIP-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNHIT3
Synonyms:TRIP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000273611.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12309 ZNHIT3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604500 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15649

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

PEHO syndrome (PEHO)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by progressive encephalopathy, lack of psychomotor development, severe mental retardation, early onset epileptic seizures, optic nerve/cerebellar atrophy, pedal edema, and early death.
See also OMIM:260565
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07919331S → L in PEHO; increased protein degradation; decreased protein abundance; does not affect localization to cytoplasm and nucleus. 1 PublicationCorresponds to variant dbSNP:rs148890852EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
9326

MalaCards human disease database

More...
MalaCardsi
ZNHIT3
MIMi260565 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000273611

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2836 PEHO syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36987

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNHIT3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46397898

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001735501 – 155Zinc finger HIT domain-containing protein 3Add BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei80PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15649

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15649

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15649

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15649

PeptideAtlas

More...
PeptideAtlasi
Q15649

PRoteomics IDEntifications database

More...
PRIDEi
Q15649

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60687

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15649

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15649

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000273611 Expressed in 230 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZNHIT3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15649 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15649 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060019

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with NUFIP1 (PubMed:28335020).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NUFIP1Q9UHK04EBI-2563564,EBI-2563549

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114736, 36 interactors

Protein interaction database and analysis system

More...
IntActi
Q15649, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000225410

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YQQNMR-A4-46[»]
5L85NMR-A85-155[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15649

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15649

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15649

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 42HIT-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2857 Eukaryota
ENOG41123YY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010822

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230732

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055775

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15649

Identification of Orthologs from Complete Genome Data

More...
OMAi
VACYKAH

Database of Orthologous Groups

More...
OrthoDBi
1551354at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15649

TreeFam database of animal gene trees

More...
TreeFami
TF324673

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007529 Znf_HIT
IPR040197 ZNHIT3

The PANTHER Classification System

More...
PANTHERi
PTHR13483:SF11 PTHR13483:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04438 zf-HIT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51083 ZF_HIT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15649-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLKCSTVV CVICLEKPKY RCPACRVPYC SVVCFRKHKE QCNPETRPVE
60 70 80 90 100
KKIRSALPTK TVKPVENKDD DDSIADFLNS DEEEDRVSLQ NLKNLGESAT
110 120 130 140 150
LRSLLLNPHL RQLMVNLDQG EDKAKLMRAY MQEPLFVEFA DCCLGIVEPS

QNEES
Length:155
Mass (Da):17,607
Last modified:April 13, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA115FD0AA9321AB0
GO
Isoform 2 (identifier: Q15649-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-155: GESATLRSLL...IVEPSQNEES → DGLSSCHPGW...ATTPNQFLYF

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:148
Mass (Da):16,453
Checksum:iDBEB11E191297F8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X045A0A087X045_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY54A0A087WY54_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTR0A0A087WTR0_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1G0A0A087X1G0_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY42A0A087WY42_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYI8A0A087WYI8_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07919331S → L in PEHO; increased protein degradation; decreased protein abundance; does not affect localization to cytoplasm and nucleus. 1 PublicationCorresponds to variant dbSNP:rs148890852EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05515596 – 155GESAT…QNEES → DGLSSCHPGWSAAAQSRLTA TSPSQIQAILMPQPPEQLGL QAPATTPNQFLYF in isoform 2. CuratedAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF400652 mRNA Translation: AAM82423.1
AK290858 mRNA Translation: BAF83547.1
AC126327 Genomic DNA No translation available.
CH471199 Genomic DNA Translation: EAW57552.1
BC017931 mRNA Translation: AAH17931.1
L40410 mRNA Translation: AAC41737.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11312.1 [Q15649-1]
CCDS62156.1 [Q15649-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001268361.1, NM_001281432.1 [Q15649-2]
NP_001268362.1, NM_001281433.1
NP_001268363.1, NM_001281434.1
NP_004764.1, NM_004773.3 [Q15649-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2210

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000617429; ENSP00000484687; ENSG00000273611 [Q15649-1]
ENST00000619649; ENSP00000478183; ENSG00000278574 [Q15649-2]
ENST00000620324; ENSP00000479727; ENSG00000273611 [Q15649-2]
ENST00000620508; ENSP00000481504; ENSG00000278574 [Q15649-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9326

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9326

UCSC genome browser

More...
UCSCi
uc002hms.3 human [Q15649-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF400652 mRNA Translation: AAM82423.1
AK290858 mRNA Translation: BAF83547.1
AC126327 Genomic DNA No translation available.
CH471199 Genomic DNA Translation: EAW57552.1
BC017931 mRNA Translation: AAH17931.1
L40410 mRNA Translation: AAC41737.1
CCDSiCCDS11312.1 [Q15649-1]
CCDS62156.1 [Q15649-2]
RefSeqiNP_001268361.1, NM_001281432.1 [Q15649-2]
NP_001268362.1, NM_001281433.1
NP_001268363.1, NM_001281434.1
NP_004764.1, NM_004773.3 [Q15649-1]
UniGeneiHs.2210

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YQQNMR-A4-46[»]
5L85NMR-A85-155[»]
ProteinModelPortaliQ15649
SMRiQ15649
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114736, 36 interactors
IntActiQ15649, 14 interactors
STRINGi9606.ENSP00000225410

PTM databases

iPTMnetiQ15649
PhosphoSitePlusiQ15649

Polymorphism and mutation databases

BioMutaiZNHIT3
DMDMi46397898

Proteomic databases

EPDiQ15649
jPOSTiQ15649
MaxQBiQ15649
PaxDbiQ15649
PeptideAtlasiQ15649
PRIDEiQ15649
ProteomicsDBi60687

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000617429; ENSP00000484687; ENSG00000273611 [Q15649-1]
ENST00000619649; ENSP00000478183; ENSG00000278574 [Q15649-2]
ENST00000620324; ENSP00000479727; ENSG00000273611 [Q15649-2]
ENST00000620508; ENSP00000481504; ENSG00000278574 [Q15649-1]
GeneIDi9326
KEGGihsa:9326
UCSCiuc002hms.3 human [Q15649-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9326
DisGeNETi9326
EuPathDBiHostDB:ENSG00000273611.4

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNHIT3
HGNCiHGNC:12309 ZNHIT3
HPAiHPA060019
MalaCardsiZNHIT3
MIMi260565 phenotype
604500 gene
neXtProtiNX_Q15649
OpenTargetsiENSG00000273611
Orphaneti2836 PEHO syndrome
PharmGKBiPA36987

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2857 Eukaryota
ENOG41123YY LUCA
GeneTreeiENSGT00390000010822
HOGENOMiHOG000230732
HOVERGENiHBG055775
InParanoidiQ15649
OMAiVACYKAH
OrthoDBi1551354at2759
PhylomeDBiQ15649
TreeFamiTF324673

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNHIT3 human
EvolutionaryTraceiQ15649

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9326

Protein Ontology

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PROi
PR:Q15649

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000273611 Expressed in 230 organ(s), highest expression level in oocyte
CleanExiHS_ZNHIT3
ExpressionAtlasiQ15649 baseline and differential
GenevisibleiQ15649 HS

Family and domain databases

InterProiView protein in InterPro
IPR007529 Znf_HIT
IPR040197 ZNHIT3
PANTHERiPTHR13483:SF11 PTHR13483:SF11, 1 hit
PfamiView protein in Pfam
PF04438 zf-HIT, 1 hit
PROSITEiView protein in PROSITE
PS51083 ZF_HIT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNHI3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15649
Secondary accession number(s): A8K493, K7EQP1, Q8WVJ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 13, 2004
Last modified: January 16, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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