ZNHIT3

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	11 – 42	HIT-typePROSITE-ProRule annotationAdd BLAST		32

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
thyroid hormone receptor binding
Source: UniProtKB
Traceable author statementⁱ
- 7776974

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 7776974

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger HIT domain-containing protein 3 Alternative name(s): HNF-4a coactivator Thyroid hormone receptor interactor 3 Thyroid receptor-interacting protein 3 Short name: TR-interacting protein 3 Short name: TRIP-3
Gene namesⁱ	Name:ZNHIT3 Synonyms:TRIP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000273611.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12309 ZNHIT3
MIMⁱ	604500 gene
neXtProtⁱ	NX_Q15649

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

PEHO syndrome (PEHO)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive syndrome characterized by progressive encephalopathy, lack of psychomotor development, severe mental retardation, early onset epileptic seizures, optic nerve/cerebellar atrophy, pedal edema, and early death.

Keywords - Diseaseⁱ

Disease mutation, Epilepsy, Mental retardation, Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9326
MalaCards human disease database More...MalaCardsⁱ	ZNHIT3
MIMⁱ	260565 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000273611
PharmGKBⁱ	PA36987

Polymorphism and mutation databases

DMDMⁱ	46397898

DMDMⁱ

46397898

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000173550	1 – 155	Zinc finger HIT domain-containing protein 3Add BLAST		155

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	80	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q15649
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15649
PaxDbⁱ	Q15649
PeptideAtlas More...PeptideAtlasⁱ	Q15649
PRIDEⁱ	Q15649
ProteomicsDBⁱ	60687

PTM databases

iPTMnetⁱ	Q15649
PhosphoSitePlusⁱ	Q15649

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000273611 Expressed in 230 organ(s), highest expression level in oocyte
CleanExⁱ	HS_ZNHIT3
ExpressionAtlasⁱ	Q15649 baseline and differential
Genevisibleⁱ	Q15649 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060019

HPAⁱ

HPA060019

Interactionⁱ

Subunit structureⁱ

Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with NUFIP1 (PubMed:28335020).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NUFIP1	Q9UHK0	4	EBI-2563564,EBI-2563549

With

Entry

#Exp.

IntAct

Notes

NUFIP1

Q9UHK0

4

EBI-2563564,EBI-2563549

GO - Molecular functionⁱ

thyroid hormone receptor binding
Source: UniProtKB
Traceable author statementⁱ
- 7776974

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114736, 36 interactors
IntActⁱ	Q15649, 14 interactors
STRINGⁱ	9606.ENSP00000225410

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	12 – 14	Combined sources	3
Beta strandⁱ	19 – 21	Combined sources	3
Turnⁱ	23 – 25	Combined sources	3
Beta strandⁱ	28 – 31	Combined sources	4
Helixⁱ	32 – 41	Combined sources	10
Helixⁱ	89 – 97	Combined sources	9
Helixⁱ	99 – 102	Combined sources	4
Turnⁱ	103 – 106	Combined sources	4
Helixⁱ	108 – 119	Combined sources	12
Helixⁱ	123 – 129	Combined sources	7
Turnⁱ	130 – 132	Combined sources	3
Helixⁱ	134 – 147	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15649
SMRⁱ	Q15649
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q15649

EvolutionaryTraceⁱ

Q15649

Family & Domainsⁱ

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	11 – 42	HIT-typePROSITE-ProRule annotationAdd BLAST		32

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2857 Eukaryota ENOG41123YY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010822
HOGENOMⁱ	HOG000230732
HOVERGENⁱ	HBG055775
InParanoidⁱ	Q15649
OMAⁱ	KCSAPYC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VWN
PhylomeDBⁱ	Q15649
TreeFamⁱ	TF324673

Family and domain databases

InterProⁱ	View protein in InterPro IPR007529 Znf_HIT
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04438 zf-HIT, 1 hit
PROSITEⁱ	View protein in PROSITE PS51083 ZF_HIT, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15649-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLKCSTVV CVICLEKPKY RCPACRVPYC SVVCFRKHKE QCNPETRPVE 
        60         70         80         90        100
KKIRSALPTK TVKPVENKDD DDSIADFLNS DEEEDRVSLQ NLKNLGESAT 
       110        120        130        140        150
LRSLLLNPHL RQLMVNLDQG EDKAKLMRAY MQEPLFVEFA DCCLGIVEPS 

QNEES

Length:155

Mass (Da):17,607

Last modified:April 13, 2004 - v2

Checksum:ⁱA115FD0AA9321AB0

GO

Isoform 2 (identifier: Q15649-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
96-155: GESATLRSLL...IVEPSQNEES → DGLSSCHPGW...ATTPNQFLYF

« Hide

        10         20         30         40         50
MASLKCSTVV CVICLEKPKY RCPACRVPYC SVVCFRKHKE QCNPETRPVE 
        60         70         80         90        100
KKIRSALPTK TVKPVENKDD DDSIADFLNS DEEEDRVSLQ NLKNLDGLSS 
       110        120        130        140 
CHPGWSAAAQ SRLTATSPSQ IQAILMPQPP EQLGLQAPAT TPNQFLYF

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »

Length:148

Mass (Da):16,453

Checksum:ⁱDBEB11E191297F8D

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087X045	A0A087X045_HUMAN	Zinc finger HIT domain-containing p... Zinc finger HIT domain-containing protein 3	ZNHIT3	42	Annotation score:
A0A087WY54	A0A087WY54_HUMAN	Zinc finger HIT domain-containing p... Zinc finger HIT domain-containing protein 3	ZNHIT3	90	Annotation score:
A0A087WTR0	A0A087WTR0_HUMAN	Zinc finger HIT domain-containing p... Zinc finger HIT domain-containing protein 3	ZNHIT3	40	Annotation score:
A0A087X1G0	A0A087X1G0_HUMAN	Zinc finger HIT domain-containing p... Zinc finger HIT domain-containing protein 3	ZNHIT3	29	Annotation score:
A0A087WY42	A0A087WY42_HUMAN	Zinc finger HIT domain-containing p... Zinc finger HIT domain-containing protein 3	ZNHIT3	42	Annotation score:
A0A087WYI8	A0A087WYI8_HUMAN	Zinc finger HIT domain-containing p... Zinc finger HIT domain-containing protein 3	ZNHIT3	12	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_079193	31	S → L in PEHO; increased protein degradation; decreased protein abundance; does not affect localization to cytoplasm and nucleus. 1 PublicationCorresponds to variant dbSNP:rs148890852EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055155	96 – 155	GESAT…QNEES → DGLSSCHPGWSAAAQSRLTA TSPSQIQAILMPQPPEQLGL QAPATTPNQFLYF in isoform 2. CuratedAdd BLAST		60

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF400652 mRNA Translation: AAM82423.1 AK290858 mRNA Translation: BAF83547.1 AC126327 Genomic DNA No translation available. CH471199 Genomic DNA Translation: EAW57552.1 BC017931 mRNA Translation: AAH17931.1 L40410 mRNA Translation: AAC41737.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11312.1 [Q15649-1] CCDS62156.1 [Q15649-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001268361.1, NM_001281432.1 [Q15649-2] NP_001268362.1, NM_001281433.1 NP_001268363.1, NM_001281434.1 NP_004764.1, NM_004773.3 [Q15649-1]
UniGeneⁱ	Hs.2210

Genome annotation databases

Ensemblⁱ	ENST00000617429; ENSP00000484687; ENSG00000273611 [Q15649-1] ENST00000619649; ENSP00000478183; ENSG00000278574 [Q15649-2] ENST00000620324; ENSP00000479727; ENSG00000273611 [Q15649-2] ENST00000620508; ENSP00000481504; ENSG00000278574 [Q15649-1]
GeneIDⁱ	9326
KEGGⁱ	hsa:9326
UCSC genome browser More...UCSCⁱ	uc002hms.3 human [Q15649-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15649	Zinc finger, HIT type 3, isoform CRA_a		HUMAN		155	UniRef100_Q15649
ZNHIT3 isoform 1		PANTR		42
Zinc finger HIT domain-containing protein 3		HUMAN		42

Protein	Similar proteins		Species	Score	Length	Source
Q15649	Zinc finger HIT domain-containing protein 3 (Fragment)		MACMU		147	UniRef90_Q15649
Zinc finger HIT domain-containing protein 3 (Fragment)		PANTR		141
Zinc finger, HIT type 3, isoform CRA_a		HUMAN		155
Uncharacterized protein		NOMLE		156
ZNHIT3 isoform 1		PONAB		42
+30
Q15649-2	ZNHIT3 isoform 6		PANTR		148	UniRef90_Q15649-2
Uncharacterized protein		PANPA		148
Zinc finger HIT-type containing 3		GORGO		148
ZNHIT3 isoform 6		PONAB		131
UPI000DC18EA8		THEGE		131

Protein	Similar proteins		Species	Score	Length	Source
Q15649	Zinc finger HIT domain-containing protein 3 (Fragment)		MACMU		147	UniRef50_Q15649
Zinc finger HIT domain-containing protein 3 (Fragment)		PANTR		141
Zinc finger HIT domain-containing protein 3		MOUSE		151
Zinc finger HIT domain-containing protein 3		BOVIN		179
Zinc finger, HIT type 3, isoform CRA_a		HUMAN		155
+125
Q15649-2	Zinc finger HIT-type containing 3		GORGO		148	UniRef50_Q15649-2
ZNHIT3 isoform 6		PANTR		148
Uncharacterized protein		PANPA		148
ZNHIT3 isoform 6		PONAB		131
Uncharacterized protein		AOTNA		130
+10

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF400652 mRNA Translation: AAM82423.1 AK290858 mRNA Translation: BAF83547.1 AC126327 Genomic DNA No translation available. CH471199 Genomic DNA Translation: EAW57552.1 BC017931 mRNA Translation: AAH17931.1 L40410 mRNA Translation: AAC41737.1
CCDSⁱ	CCDS11312.1 [Q15649-1] CCDS62156.1 [Q15649-2]
RefSeqⁱ	NP_001268361.1, NM_001281432.1 [Q15649-2] NP_001268362.1, NM_001281433.1 NP_001268363.1, NM_001281434.1 NP_004764.1, NM_004773.3 [Q15649-1]
UniGeneⁱ	Hs.2210

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2YQQ	NMR	-	A	4-46	[»]
	5L85	NMR	-	A	85-155	[»]
ProteinModelPortalⁱ	Q15649
SMRⁱ	Q15649
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114736, 36 interactors
IntActⁱ	Q15649, 14 interactors
STRINGⁱ	9606.ENSP00000225410

PTM databases

iPTMnetⁱ	Q15649
PhosphoSitePlusⁱ	Q15649

Polymorphism and mutation databases

DMDMⁱ	46397898

DMDMⁱ

46397898

Proteomic databases

EPDⁱ	Q15649
MaxQBⁱ	Q15649
PaxDbⁱ	Q15649
PeptideAtlasⁱ	Q15649
PRIDEⁱ	Q15649
ProteomicsDBⁱ	60687

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000617429; ENSP00000484687; ENSG00000273611 [Q15649-1] ENST00000619649; ENSP00000478183; ENSG00000278574 [Q15649-2] ENST00000620324; ENSP00000479727; ENSG00000273611 [Q15649-2] ENST00000620508; ENSP00000481504; ENSG00000278574 [Q15649-1]
GeneIDⁱ	9326
KEGGⁱ	hsa:9326
UCSCⁱ	uc002hms.3 human [Q15649-1]

Organism-specific databases

CTDⁱ	9326
DisGeNETⁱ	9326
EuPathDBⁱ	HostDB:ENSG00000273611.4
GeneCardsⁱ	ZNHIT3
HGNCⁱ	HGNC:12309 ZNHIT3
HPAⁱ	HPA060019
MalaCardsⁱ	ZNHIT3
MIMⁱ	260565 phenotype 604500 gene
neXtProtⁱ	NX_Q15649
OpenTargetsⁱ	ENSG00000273611
PharmGKBⁱ	PA36987
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2857 Eukaryota ENOG41123YY LUCA
GeneTreeⁱ	ENSGT00390000010822
HOGENOMⁱ	HOG000230732
HOVERGENⁱ	HBG055775
InParanoidⁱ	Q15649
OMAⁱ	KCSAPYC
OrthoDBⁱ	EOG091G0VWN
PhylomeDBⁱ	Q15649
TreeFamⁱ	TF324673

Miscellaneous databases

ChiTaRSⁱ	ZNHIT3 human
EvolutionaryTraceⁱ	Q15649
GenomeRNAiⁱ	9326
Protein Ontology More...PROⁱ	PR:Q15649
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000273611 Expressed in 230 organ(s), highest expression level in oocyte
CleanExⁱ	HS_ZNHIT3
ExpressionAtlasⁱ	Q15649 baseline and differential
Genevisibleⁱ	Q15649 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007529 Znf_HIT
Pfamⁱ	View protein in Pfam PF04438 zf-HIT, 1 hit
PROSITEⁱ	View protein in PROSITE PS51083 ZF_HIT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZNHI3_HUMAN
Accessionⁱ	Q15649Primary (citable) accession number: Q15649 Secondary accession number(s): A8K493, K7EQP1, Q8WVJ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	April 13, 2004
	Last modified:	September 12, 2018
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15649 (ZNHI3_HUMAN)

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Zinc finger HIT domain-containing protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ