UniProtKB - Q15649 (ZNHI3_HUMAN)
Zinc finger HIT domain-containing protein 3
ZNHIT3
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 11 – 42 | HIT-typePROSITE-ProRule annotationAdd BLAST | 32 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- thyroid hormone receptor binding Source: UniProtKB
GO - Biological processi
- box C/D snoRNP assembly Source: GO_Central
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- regulation of transcription, DNA-templated Source: UniProtKB
- snoRNA localization Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q15649 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger HIT domain-containing protein 3Alternative name(s): HNF-4a coactivator Thyroid hormone receptor interactor 3 Thyroid receptor-interacting protein 3 Short name: TR-interacting protein 3 Short name: TRIP-3 |
Gene namesi | Name:ZNHIT3 Synonyms:TRIP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12309, ZNHIT3 |
MIMi | 604500, gene |
neXtProti | NX_Q15649 |
VEuPathDBi | HostDB:ENSG00000273611.4 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- pre-snoRNP complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
PEHO syndrome (PEHO)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079193 | 31 | S → L in PEHO; increased protein degradation; decreased protein abundance; does not affect localization to cytoplasm and nucleus. 1 PublicationCorresponds to variant dbSNP:rs148890852EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Epilepsy, Mental retardation, NeurodegenerationOrganism-specific databases
DisGeNETi | 9326 |
MalaCardsi | ZNHIT3 |
MIMi | 260565, phenotype |
OpenTargetsi | ENSG00000273611 |
Orphaneti | 2836, PEHO syndrome |
PharmGKBi | PA36987 |
Miscellaneous databases
Pharosi | Q15649, Tbio |
Genetic variation databases
BioMutai | ZNHIT3 |
DMDMi | 46397898 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173550 | 1 – 155 | Zinc finger HIT domain-containing protein 3Add BLAST | 155 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 80 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15649 |
jPOSTi | Q15649 |
MassIVEi | Q15649 |
MaxQBi | Q15649 |
PaxDbi | Q15649 |
PeptideAtlasi | Q15649 |
PRIDEi | Q15649 |
ProteomicsDBi | 60687 [Q15649-1] |
PTM databases
iPTMneti | Q15649 |
PhosphoSitePlusi | Q15649 |
Expressioni
Gene expression databases
Bgeei | ENSG00000273611, Expressed in oocyte and 241 other tissues |
ExpressionAtlasi | Q15649, baseline and differential |
Genevisiblei | Q15649, HS |
Organism-specific databases
HPAi | ENSG00000273611, Low tissue specificity |
Interactioni
Subunit structurei
Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR) (PubMed:7776974). Requires the presence of thyroid hormone for its interaction (PubMed:7776974).
Interacts with NUFIP1 (PubMed:28335020).
Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP (PubMed:28561026).
2 PublicationsBinary interactionsi
Q15649
With | #Exp. | IntAct |
---|---|---|
NUFIP1 [Q9UHK0] | 7 | EBI-2563564,EBI-2563549 |
GO - Molecular functioni
- thyroid hormone receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114736, 39 interactors |
IntActi | Q15649, 15 interactors |
STRINGi | 9606.ENSP00000484687 |
Miscellaneous databases
RNActi | Q15649, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q15649 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15649 |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 11 – 42 | HIT-typePROSITE-ProRule annotationAdd BLAST | 32 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2857, Eukaryota |
GeneTreei | ENSGT00390000010822 |
HOGENOMi | CLU_117355_1_0_1 |
InParanoidi | Q15649 |
OMAi | KKHKEQC |
PhylomeDBi | Q15649 |
TreeFami | TF324673 |
Family and domain databases
InterProi | View protein in InterPro IPR007529, Znf_HIT IPR040197, ZNHIT3 |
PANTHERi | PTHR13483:SF11, PTHR13483:SF11, 1 hit |
Pfami | View protein in Pfam PF04438, zf-HIT, 1 hit |
PROSITEi | View protein in PROSITE PS51083, ZF_HIT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASLKCSTVV CVICLEKPKY RCPACRVPYC SVVCFRKHKE QCNPETRPVE
60 70 80 90 100
KKIRSALPTK TVKPVENKDD DDSIADFLNS DEEEDRVSLQ NLKNLGESAT
110 120 130 140 150
LRSLLLNPHL RQLMVNLDQG EDKAKLMRAY MQEPLFVEFA DCCLGIVEPS
QNEES
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WY54 | A0A087WY54_HUMAN | Zinc finger HIT domain-containing p... | ZNHIT3 | 90 | Annotation score: | ||
A0A087X045 | A0A087X045_HUMAN | Zinc finger HIT domain-containing p... | ZNHIT3 | 42 | Annotation score: | ||
A0A087WTR0 | A0A087WTR0_HUMAN | Zinc finger HIT domain-containing p... | ZNHIT3 | 40 | Annotation score: | ||
A0A087WY42 | A0A087WY42_HUMAN | Zinc finger HIT domain-containing p... | ZNHIT3 | 42 | Annotation score: | ||
A0A087WYI8 | A0A087WYI8_HUMAN | Zinc finger HIT domain-containing p... | ZNHIT3 | 12 | Annotation score: | ||
A0A087X1G0 | A0A087X1G0_HUMAN | Zinc finger HIT domain-containing p... | ZNHIT3 | 29 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079193 | 31 | S → L in PEHO; increased protein degradation; decreased protein abundance; does not affect localization to cytoplasm and nucleus. 1 PublicationCorresponds to variant dbSNP:rs148890852EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055155 | 96 – 155 | GESAT…QNEES → DGLSSCHPGWSAAAQSRLTA TSPSQIQAILMPQPPEQLGL QAPATTPNQFLYF in isoform 2. CuratedAdd BLAST | 60 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF400652 mRNA Translation: AAM82423.1 AK290858 mRNA Translation: BAF83547.1 AC126327 Genomic DNA No translation available. CH471199 Genomic DNA Translation: EAW57552.1 BC017931 mRNA Translation: AAH17931.1 L40410 mRNA Translation: AAC41737.1 |
CCDSi | CCDS11312.1 [Q15649-1] CCDS62156.1 [Q15649-2] |
RefSeqi | NP_001268361.1, NM_001281432.1 [Q15649-2] NP_001268362.1, NM_001281433.1 NP_001268363.1, NM_001281434.1 NP_004764.1, NM_004773.3 [Q15649-1] |
Genome annotation databases
Ensembli | ENST00000617429; ENSP00000484687; ENSG00000273611 [Q15649-1] ENST00000619649; ENSP00000478183; ENSG00000278574 [Q15649-2] ENST00000620324; ENSP00000479727; ENSG00000273611 [Q15649-2] ENST00000620508; ENSP00000481504; ENSG00000278574 [Q15649-1] |
GeneIDi | 9326 |
KEGGi | hsa:9326 |
UCSCi | uc002hms.3, human [Q15649-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF400652 mRNA Translation: AAM82423.1 AK290858 mRNA Translation: BAF83547.1 AC126327 Genomic DNA No translation available. CH471199 Genomic DNA Translation: EAW57552.1 BC017931 mRNA Translation: AAH17931.1 L40410 mRNA Translation: AAC41737.1 |
CCDSi | CCDS11312.1 [Q15649-1] CCDS62156.1 [Q15649-2] |
RefSeqi | NP_001268361.1, NM_001281432.1 [Q15649-2] NP_001268362.1, NM_001281433.1 NP_001268363.1, NM_001281434.1 NP_004764.1, NM_004773.3 [Q15649-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2YQQ | NMR | - | A | 4-46 | [»] | |
5L85 | NMR | - | A | 85-155 | [»] | |
SMRi | Q15649 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114736, 39 interactors |
IntActi | Q15649, 15 interactors |
STRINGi | 9606.ENSP00000484687 |
PTM databases
iPTMneti | Q15649 |
PhosphoSitePlusi | Q15649 |
Genetic variation databases
BioMutai | ZNHIT3 |
DMDMi | 46397898 |
Proteomic databases
EPDi | Q15649 |
jPOSTi | Q15649 |
MassIVEi | Q15649 |
MaxQBi | Q15649 |
PaxDbi | Q15649 |
PeptideAtlasi | Q15649 |
PRIDEi | Q15649 |
ProteomicsDBi | 60687 [Q15649-1] |
Protocols and materials databases
Antibodypediai | 74086, 56 antibodies |
Genome annotation databases
Ensembli | ENST00000617429; ENSP00000484687; ENSG00000273611 [Q15649-1] ENST00000619649; ENSP00000478183; ENSG00000278574 [Q15649-2] ENST00000620324; ENSP00000479727; ENSG00000273611 [Q15649-2] ENST00000620508; ENSP00000481504; ENSG00000278574 [Q15649-1] |
GeneIDi | 9326 |
KEGGi | hsa:9326 |
UCSCi | uc002hms.3, human [Q15649-1] |
Organism-specific databases
CTDi | 9326 |
DisGeNETi | 9326 |
GeneCardsi | ZNHIT3 |
HGNCi | HGNC:12309, ZNHIT3 |
HPAi | ENSG00000273611, Low tissue specificity |
MalaCardsi | ZNHIT3 |
MIMi | 260565, phenotype 604500, gene |
neXtProti | NX_Q15649 |
OpenTargetsi | ENSG00000273611 |
Orphaneti | 2836, PEHO syndrome |
PharmGKBi | PA36987 |
VEuPathDBi | HostDB:ENSG00000273611.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2857, Eukaryota |
GeneTreei | ENSGT00390000010822 |
HOGENOMi | CLU_117355_1_0_1 |
InParanoidi | Q15649 |
OMAi | KKHKEQC |
PhylomeDBi | Q15649 |
TreeFami | TF324673 |
Enzyme and pathway databases
PathwayCommonsi | Q15649 |
Miscellaneous databases
BioGRID-ORCSi | 9326, 401 hits in 881 CRISPR screens |
ChiTaRSi | ZNHIT3, human |
EvolutionaryTracei | Q15649 |
GenomeRNAii | 9326 |
Pharosi | Q15649, Tbio |
PROi | PR:Q15649 |
RNActi | Q15649, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000273611, Expressed in oocyte and 241 other tissues |
ExpressionAtlasi | Q15649, baseline and differential |
Genevisiblei | Q15649, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007529, Znf_HIT IPR040197, ZNHIT3 |
PANTHERi | PTHR13483:SF11, PTHR13483:SF11, 1 hit |
Pfami | View protein in Pfam PF04438, zf-HIT, 1 hit |
PROSITEi | View protein in PROSITE PS51083, ZF_HIT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNHI3_HUMAN | |
Accessioni | Q15649Primary (citable) accession number: Q15649 Secondary accession number(s): A8K493, K7EQP1, Q8WVJ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 13, 2004 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references