Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger HIT domain-containing protein 3

Gene

ZNHIT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 42HIT-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger HIT domain-containing protein 3
Alternative name(s):
HNF-4a coactivator
Thyroid hormone receptor interactor 3
Thyroid receptor-interacting protein 3
Short name:
TR-interacting protein 3
Short name:
TRIP-3
Gene namesi
Name:ZNHIT3
Synonyms:TRIP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000273611.4
HGNCiHGNC:12309 ZNHIT3
MIMi604500 gene
neXtProtiNX_Q15649

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

PEHO syndrome (PEHO)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by progressive encephalopathy, lack of psychomotor development, severe mental retardation, early onset epileptic seizures, optic nerve/cerebellar atrophy, pedal edema, and early death.
See also OMIM:260565
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07919331S → L in PEHO; increased protein degradation; decreased protein abundance; does not affect localization to cytoplasm and nucleus. 1 PublicationCorresponds to variant dbSNP:rs148890852EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation, Neurodegeneration

Organism-specific databases

DisGeNETi9326
MalaCardsiZNHIT3
MIMi260565 phenotype
OpenTargetsiENSG00000273611
PharmGKBiPA36987

Polymorphism and mutation databases

DMDMi46397898

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735501 – 155Zinc finger HIT domain-containing protein 3Add BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15649
MaxQBiQ15649
PaxDbiQ15649
PeptideAtlasiQ15649
PRIDEiQ15649
ProteomicsDBi60687

PTM databases

iPTMnetiQ15649
PhosphoSitePlusiQ15649

Expressioni

Gene expression databases

BgeeiENSG00000273611 Expressed in 230 organ(s), highest expression level in oocyte
CleanExiHS_ZNHIT3
ExpressionAtlasiQ15649 baseline and differential
GenevisibleiQ15649 HS

Organism-specific databases

HPAiHPA060019

Interactioni

Subunit structurei

Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with NUFIP1 (PubMed:28335020).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NUFIP1Q9UHK04EBI-2563564,EBI-2563549

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114736, 36 interactors
IntActiQ15649, 14 interactors
STRINGi9606.ENSP00000225410

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15649
SMRiQ15649
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15649

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 42HIT-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2857 Eukaryota
ENOG41123YY LUCA
GeneTreeiENSGT00390000010822
HOGENOMiHOG000230732
HOVERGENiHBG055775
InParanoidiQ15649
OMAiKCSAPYC
OrthoDBiEOG091G0VWN
PhylomeDBiQ15649
TreeFamiTF324673

Family and domain databases

InterProiView protein in InterPro
IPR007529 Znf_HIT
PfamiView protein in Pfam
PF04438 zf-HIT, 1 hit
PROSITEiView protein in PROSITE
PS51083 ZF_HIT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15649-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLKCSTVV CVICLEKPKY RCPACRVPYC SVVCFRKHKE QCNPETRPVE
60 70 80 90 100
KKIRSALPTK TVKPVENKDD DDSIADFLNS DEEEDRVSLQ NLKNLGESAT
110 120 130 140 150
LRSLLLNPHL RQLMVNLDQG EDKAKLMRAY MQEPLFVEFA DCCLGIVEPS

QNEES
Length:155
Mass (Da):17,607
Last modified:April 13, 2004 - v2
Checksum:iA115FD0AA9321AB0
GO
Isoform 2 (identifier: Q15649-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-155: GESATLRSLL...IVEPSQNEES → DGLSSCHPGW...ATTPNQFLYF

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:148
Mass (Da):16,453
Checksum:iDBEB11E191297F8D
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X045A0A087X045_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
42Annotation score:
A0A087WY54A0A087WY54_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
90Annotation score:
A0A087WTR0A0A087WTR0_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
40Annotation score:
A0A087X1G0A0A087X1G0_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
29Annotation score:
A0A087WY42A0A087WY42_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
42Annotation score:
A0A087WYI8A0A087WYI8_HUMAN
Zinc finger HIT domain-containing p...
ZNHIT3
12Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07919331S → L in PEHO; increased protein degradation; decreased protein abundance; does not affect localization to cytoplasm and nucleus. 1 PublicationCorresponds to variant dbSNP:rs148890852EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05515596 – 155GESAT…QNEES → DGLSSCHPGWSAAAQSRLTA TSPSQIQAILMPQPPEQLGL QAPATTPNQFLYF in isoform 2. CuratedAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF400652 mRNA Translation: AAM82423.1
AK290858 mRNA Translation: BAF83547.1
AC126327 Genomic DNA No translation available.
CH471199 Genomic DNA Translation: EAW57552.1
BC017931 mRNA Translation: AAH17931.1
L40410 mRNA Translation: AAC41737.1
CCDSiCCDS11312.1 [Q15649-1]
CCDS62156.1 [Q15649-2]
RefSeqiNP_001268361.1, NM_001281432.1 [Q15649-2]
NP_001268362.1, NM_001281433.1
NP_001268363.1, NM_001281434.1
NP_004764.1, NM_004773.3 [Q15649-1]
UniGeneiHs.2210

Genome annotation databases

EnsembliENST00000617429; ENSP00000484687; ENSG00000273611 [Q15649-1]
ENST00000619649; ENSP00000478183; ENSG00000278574 [Q15649-2]
ENST00000620324; ENSP00000479727; ENSG00000273611 [Q15649-2]
ENST00000620508; ENSP00000481504; ENSG00000278574 [Q15649-1]
GeneIDi9326
KEGGihsa:9326
UCSCiuc002hms.3 human [Q15649-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF400652 mRNA Translation: AAM82423.1
AK290858 mRNA Translation: BAF83547.1
AC126327 Genomic DNA No translation available.
CH471199 Genomic DNA Translation: EAW57552.1
BC017931 mRNA Translation: AAH17931.1
L40410 mRNA Translation: AAC41737.1
CCDSiCCDS11312.1 [Q15649-1]
CCDS62156.1 [Q15649-2]
RefSeqiNP_001268361.1, NM_001281432.1 [Q15649-2]
NP_001268362.1, NM_001281433.1
NP_001268363.1, NM_001281434.1
NP_004764.1, NM_004773.3 [Q15649-1]
UniGeneiHs.2210

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YQQNMR-A4-46[»]
5L85NMR-A85-155[»]
ProteinModelPortaliQ15649
SMRiQ15649
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114736, 36 interactors
IntActiQ15649, 14 interactors
STRINGi9606.ENSP00000225410

PTM databases

iPTMnetiQ15649
PhosphoSitePlusiQ15649

Polymorphism and mutation databases

DMDMi46397898

Proteomic databases

EPDiQ15649
MaxQBiQ15649
PaxDbiQ15649
PeptideAtlasiQ15649
PRIDEiQ15649
ProteomicsDBi60687

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000617429; ENSP00000484687; ENSG00000273611 [Q15649-1]
ENST00000619649; ENSP00000478183; ENSG00000278574 [Q15649-2]
ENST00000620324; ENSP00000479727; ENSG00000273611 [Q15649-2]
ENST00000620508; ENSP00000481504; ENSG00000278574 [Q15649-1]
GeneIDi9326
KEGGihsa:9326
UCSCiuc002hms.3 human [Q15649-1]

Organism-specific databases

CTDi9326
DisGeNETi9326
EuPathDBiHostDB:ENSG00000273611.4
GeneCardsiZNHIT3
HGNCiHGNC:12309 ZNHIT3
HPAiHPA060019
MalaCardsiZNHIT3
MIMi260565 phenotype
604500 gene
neXtProtiNX_Q15649
OpenTargetsiENSG00000273611
PharmGKBiPA36987
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2857 Eukaryota
ENOG41123YY LUCA
GeneTreeiENSGT00390000010822
HOGENOMiHOG000230732
HOVERGENiHBG055775
InParanoidiQ15649
OMAiKCSAPYC
OrthoDBiEOG091G0VWN
PhylomeDBiQ15649
TreeFamiTF324673

Miscellaneous databases

ChiTaRSiZNHIT3 human
EvolutionaryTraceiQ15649
GenomeRNAii9326
PROiPR:Q15649
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000273611 Expressed in 230 organ(s), highest expression level in oocyte
CleanExiHS_ZNHIT3
ExpressionAtlasiQ15649 baseline and differential
GenevisibleiQ15649 HS

Family and domain databases

InterProiView protein in InterPro
IPR007529 Znf_HIT
PfamiView protein in Pfam
PF04438 zf-HIT, 1 hit
PROSITEiView protein in PROSITE
PS51083 ZF_HIT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZNHI3_HUMAN
AccessioniPrimary (citable) accession number: Q15649
Secondary accession number(s): A8K493, K7EQP1, Q8WVJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 13, 2004
Last modified: September 12, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again