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Entry version 171 (16 Oct 2019)
Sequence version 2 (10 Jan 2006)
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Protein

Pachytene checkpoint protein 2 homolog

Gene

TRIP13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi179 – 186ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Meiosis, Oogenesis, Spermatogenesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pachytene checkpoint protein 2 homolog
Alternative name(s):
Human papillomavirus type 16 E1 protein-binding protein
Short name:
16E1-BP
Short name:
HPV16 E1 protein-binding protein
Thyroid hormone receptor interactor 13
Thyroid receptor-interacting protein 13
Short name:
TR-interacting protein 13
Short name:
TRIP-13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIP13
Synonyms:PCH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12307 TRIP13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604507 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15645

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mosaic variegated aneuploidy syndrome 3 (MVA3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. MVA3 is caused by biallelic mutations in the TRIP13 gene.
Disease descriptionA form of mosaic variegated aneuploidy syndrome, a severe disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases. MVA3 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079275354 – 432Missing in MVA3; loss of protein expression; impairment of spindle assembly checkpoint. 1 PublicationAdd BLAST79

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9319

MalaCards human disease database

More...
MalaCardsi
TRIP13
MIMi617598 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000071539

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1052 Mosaic variegated aneuploidy syndrome
654 Nephroblastoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36986

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15645

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIP13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85541056

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000847821 – 432Pachytene checkpoint protein 2 homologAdd BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15645

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15645

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15645

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15645

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15645

PeptideAtlas

More...
PeptideAtlasi
Q15645

PRoteomics IDEntifications database

More...
PRIDEi
Q15645

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60681 [Q15645-1]
60682 [Q15645-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15645

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15645

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15645

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000071539 Expressed in 152 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15645 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15645 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005727
HPA053093

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction.

Interacts with HPV16 E1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-358993,EBI-358993
Q96EJ43EBI-358993,EBI-750454
AMDHD2Q9Y3033EBI-358993,EBI-2798672
ARL11Q969Q43EBI-358993,EBI-751892
ARSAP1528912EBI-358993,EBI-2117357
C11orf54Q9H0W93EBI-358993,EBI-740204
C4orf33Q8N1A65EBI-358993,EBI-10264911
CFPA0A0S2Z5153EBI-358993,EBI-16434710
COMTP219643EBI-358993,EBI-372265
COMTP21964-23EBI-358993,EBI-10200977
CRYBA2P536724EBI-358993,EBI-750444
CYB5R2Q6BCY44EBI-358993,EBI-744761
DDAH2O958655EBI-358993,EBI-749139
DIP2AQ146893EBI-358993,EBI-2564275
DIP2AQ14689-63EBI-358993,EBI-10233719
DPYSL4O145313EBI-358993,EBI-719542
FBLN5Q9UBX53EBI-358993,EBI-947897
FBXO8A0A0S2Z5763EBI-358993,EBI-16434722
FNDC3BQ53EP0-35EBI-358993,EBI-10242151
GALTA0A0S2Z4I03EBI-358993,EBI-16434744
GALTP079024EBI-358993,EBI-750827
GLYCTKQ8IVS88EBI-358993,EBI-748515
HDHD3Q9BSH55EBI-358993,EBI-745201
KRTAP12-1P599905EBI-358993,EBI-10210845
KRTAP12-2P599913EBI-358993,EBI-10176379
KRTAP26-1Q6PEX33EBI-358993,EBI-3957672
KYAT1Q167733EBI-358993,EBI-10238309
LASP1Q148477EBI-358993,EBI-742828
LNX1Q8TBB16EBI-358993,EBI-739832
LOXL4Q96JB66EBI-358993,EBI-749562
LRR1Q96L503EBI-358993,EBI-2510106
M1APQ8TC573EBI-358993,EBI-748182
MAD2L1BPQ150137EBI-358993,EBI-712181
MEAK7Q6P9B63EBI-358993,EBI-746504
METTL15A6NJ78-45EBI-358993,EBI-10174029
MORN3Q6PF183EBI-358993,EBI-9675802
MPPED2Q157777EBI-358993,EBI-2350461
NIF3L1Q9GZT83EBI-358993,EBI-740897
NME4O007463EBI-358993,EBI-744871
PBLDP300394EBI-358993,EBI-750589
PCMTD2Q6PIM43EBI-358993,EBI-10253759
PELI1Q96FA33EBI-358993,EBI-448369
PLSCR3Q9NRY66EBI-358993,EBI-750734
PLSCR4Q9NRQ23EBI-358993,EBI-769257
PPP2CAP677755EBI-358993,EBI-712311
PRKNO602604EBI-358993,EBI-716346
QARSP478975EBI-358993,EBI-347462
QARSP47897-23EBI-358993,EBI-10209725
RHOXF2Q9BQY47EBI-358993,EBI-372094
SCP2P223074EBI-358993,EBI-1050999
SELENBP1Q132283EBI-358993,EBI-711619
SEMA4GQ9NTN93EBI-358993,EBI-6447340
SEMA4GQ9NTN9-33EBI-358993,EBI-9089805
SIGLEC5O153894EBI-358993,EBI-750381
SPRYD7Q5W1113EBI-358993,EBI-10248098
TEX37Q96LM66EBI-358993,EBI-743976
TINAGL1Q9GZM75EBI-358993,EBI-715869
TINAGL1Q9GZM7-33EBI-358993,EBI-10303636
TNRC6AQ8NDV73EBI-358993,EBI-2269715
TPT1P136933EBI-358993,EBI-1783169
VDRP114733EBI-358993,EBI-286357
WDYHV1Q96HA83EBI-358993,EBI-741158

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114730, 150 interactors

Database of interacting proteins

More...
DIPi
DIP-34493N

Protein interaction database and analysis system

More...
IntActi
Q15645, 145 interactors

Molecular INTeraction database

More...
MINTi
Q15645

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000166345

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1432
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15645

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family. PCH2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0744 Eukaryota
COG0464 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017432

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234557

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15645

KEGG Orthology (KO)

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KOi
K22399

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACQAGTE

Database of Orthologous Groups

More...
OrthoDBi
1036414at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15645

TreeFam database of animal gene trees

More...
TreeFami
TF313507

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR001270 ClpA/B
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004 AAA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00300 CLPPROTEASEA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00674 AAA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15645-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEAVGDLKQ ALPCVAESPT VHVEVHQRGS STAKKEDINL SVRKLLNRHN
60 70 80 90 100
IVFGDYTWTE FDEPFLTRNV QSVSIIDTEL KVKDSQPIDL SACTVALHIF
110 120 130 140 150
QLNEDGPSSE NLEEETENII AANHWVLPAA EFHGLWDSLV YDVEVKSHLL
160 170 180 190 200
DYVMTTLLFS DKNVNSNLIT WNRVVLLHGP PGTGKTSLCK ALAQKLTIRL
210 220 230 240 250
SSRYRYGQLI EINSHSLFSK WFSESGKLVT KMFQKIQDLI DDKDALVFVL
260 270 280 290 300
IDEVESLTAA RNACRAGTEP SDAIRVVNAV LTQIDQIKRH SNVVILTTSN
310 320 330 340 350
ITEKIDVAFV DRADIKQYIG PPSAAAIFKI YLSCLEELMK CQIIYPRQQL
360 370 380 390 400
LTLRELEMIG FIENNVSKLS LLLNDISRKS EGLSGRVLRK LPFLAHALYV
410 420 430
QAPTVTIEGF LQALSLAVDK QFEERKKLAA YI
Length:432
Mass (Da):48,551
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFB0B37462D1D581
GO
Isoform 2 (identifier: Q15645-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-406: Missing.

Note: No experimental confirmation available.
Show »
Length:196
Mass (Da):22,084
Checksum:i74AF9425508B518A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAL2H0YAL2_HUMAN
Pachytene checkpoint protein 2 homo...
TRIP13
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC41732 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079275354 – 432Missing in MVA3; loss of protein expression; impairment of spindle assembly checkpoint. 1 PublicationAdd BLAST79

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016957171 – 406Missing in isoform 2. 1 PublicationAdd BLAST236

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U96131 mRNA Translation: AAB64095.1
CR456744 mRNA Translation: CAG33025.1
AC122719 Genomic DNA No translation available.
CH471102 Genomic DNA Translation: EAX08185.1
CH471102 Genomic DNA Translation: EAX08186.1
BC000404 mRNA Translation: AAH00404.1
BC019294 mRNA Translation: AAH19294.1
L40384 mRNA Translation: AAC41732.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3858.1 [Q15645-1]

NCBI Reference Sequences

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RefSeqi
NP_004228.1, NM_004237.3 [Q15645-1]
XP_011512465.1, XM_011514163.2 [Q15645-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000166345; ENSP00000166345; ENSG00000071539 [Q15645-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9319

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9319

UCSC genome browser

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UCSCi
uc003jbr.4 human [Q15645-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96131 mRNA Translation: AAB64095.1
CR456744 mRNA Translation: CAG33025.1
AC122719 Genomic DNA No translation available.
CH471102 Genomic DNA Translation: EAX08185.1
CH471102 Genomic DNA Translation: EAX08186.1
BC000404 mRNA Translation: AAH00404.1
BC019294 mRNA Translation: AAH19294.1
L40384 mRNA Translation: AAC41732.1 Frameshift.
CCDSiCCDS3858.1 [Q15645-1]
RefSeqiNP_004228.1, NM_004237.3 [Q15645-1]
XP_011512465.1, XM_011514163.2 [Q15645-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VQ9X-ray3.02D1-432[»]
5VQAX-ray2.54A1-432[»]
5WC2X-ray2.50A1-432[»]
6F0Xelectron microscopy4.60A/B/C/D/E/F1-432[»]
SMRiQ15645
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114730, 150 interactors
DIPiDIP-34493N
IntActiQ15645, 145 interactors
MINTiQ15645
STRINGi9606.ENSP00000166345

PTM databases

iPTMnetiQ15645
PhosphoSitePlusiQ15645
SwissPalmiQ15645

Polymorphism and mutation databases

BioMutaiTRIP13
DMDMi85541056

Proteomic databases

EPDiQ15645
jPOSTiQ15645
MassIVEiQ15645
MaxQBiQ15645
PaxDbiQ15645
PeptideAtlasiQ15645
PRIDEiQ15645
ProteomicsDBi60681 [Q15645-1]
60682 [Q15645-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9319

Genome annotation databases

EnsembliENST00000166345; ENSP00000166345; ENSG00000071539 [Q15645-1]
GeneIDi9319
KEGGihsa:9319
UCSCiuc003jbr.4 human [Q15645-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9319
DisGeNETi9319

GeneCards: human genes, protein and diseases

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GeneCardsi
TRIP13
HGNCiHGNC:12307 TRIP13
HPAiHPA005727
HPA053093
MalaCardsiTRIP13
MIMi604507 gene
617598 phenotype
neXtProtiNX_Q15645
OpenTargetsiENSG00000071539
Orphaneti1052 Mosaic variegated aneuploidy syndrome
654 Nephroblastoma
PharmGKBiPA36986

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0744 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00390000017432
HOGENOMiHOG000234557
InParanoidiQ15645
KOiK22399
OMAiACQAGTE
OrthoDBi1036414at2759
PhylomeDBiQ15645
TreeFamiTF313507

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRIP13 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRIP13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9319
PharosiQ15645

Protein Ontology

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PROi
PR:Q15645

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000071539 Expressed in 152 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiQ15645 baseline and differential
GenevisibleiQ15645 HS

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR001270 ClpA/B
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PRINTSiPR00300 CLPPROTEASEA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCH2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15645
Secondary accession number(s): C9K0T3, D3DTC0, O15324
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2006
Last modified: October 16, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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