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Entry version 178 (11 Dec 2019)
Sequence version 3 (23 Mar 2010)
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Protein

Thyroid receptor-interacting protein 11

Gene

TRIP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5620924 Intraflagellar transport
R-HSA-6811438 Intra-Golgi traffic

SIGNOR Signaling Network Open Resource

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SIGNORi
Q15643

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroid receptor-interacting protein 11
Short name:
TR-interacting protein 11
Short name:
TRIP-11
Alternative name(s):
Clonal evolution-related gene on chromosome 14 protein
Golgi-associated microtubule-binding protein 210
Short name:
GMAP-210
Trip230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIP11
Synonyms:CEV14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100815.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12305 TRIP11

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604505 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q15643

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.1 Publication
Achondrogenesis 1A (ACG1A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082010264 – 1979Missing in ACG1A and ODCD. 2 PublicationsAdd BLAST1716
Natural variantiVAR_0820121160 – 1979Missing in ACG1A. 1 PublicationAdd BLAST820
Natural variantiVAR_0822851167 – 1979Missing in ACG1A. 1 PublicationAdd BLAST813
Natural variantiVAR_0820131224 – 1979Missing in ACG1A; does not localize to cis-Golgi; results in disruption of Golgi cisternal stack architecture. 1 PublicationAdd BLAST756
Natural variantiVAR_0820141321 – 1979Missing in ACG1A. 1 PublicationAdd BLAST659
Natural variantiVAR_0820151376 – 1979Missing in ACG1A. 1 PublicationAdd BLAST604
Odontochondrodysplasia (ODCD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder of skeletal and dental development characterized by mesomelic shortening of tubular bones, ligamentous laxity, scoliosis, and dentinogenesis imperfecta involving both primary and secondary dentition. Radiologic features include trident pelvis, posteriorly flattened vertebrae, and brachydactyly with cone-shaped epiphyses.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_082008105 – 196Missing in ODCD; in-frame exon 4 skipping; due to a nucleotide substitution that may also cause protein truncation. 1 PublicationAdd BLAST92
Natural variantiVAR_082009196 – 1979Missing in ODCD; due to a nucleotide substitution that causes protein truncation or in-frame exon 4 skipping. 1 PublicationAdd BLAST1784
Natural variantiVAR_082010264 – 1979Missing in ACG1A and ODCD. 2 PublicationsAdd BLAST1716
Natural variantiVAR_082011410D → Y in ODCD; due to a nucleotide substitution that causes in-frame exon 9 skipping or results in missense variant Y-410; patient cells contain both type of transcripts; the transcript lacking exon 9 is the most abundant. 1 Publication1
Natural variantiVAR_0820161512 – 1979Missing in ODCD. 1 PublicationAdd BLAST468
Natural variantiVAR_0820171806M → V in ODCD; due to a nucleotide substitution that causes missplicing of exon 18 or results in missense variant V-1806; patient cells contain both type of transcripts; the transcript with the missense variant is the most abundant. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2 – 38Missing : Abolishes tethering of intra-Golgi vesicles. 1 PublicationAdd BLAST37
Mutagenesisi1113 – 1423Missing : Abolishes interaction with RAB2A. 1 PublicationAdd BLAST311

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1754 – 1755Breakpoint for translocation to form TRIP11-PDGFRB2

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
9321

MalaCards human disease database

More...
MalaCardsi
TRIP11
MIMi184260 phenotype
200600 phenotype

Open Targets

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OpenTargetsi
ENSG00000100815

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93299 Achondrogenesis type 1A
166272 Odontochondrodysplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36984

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q15643 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIP11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
292495059

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900762 – 1979Thyroid receptor-interacting protein 11Add BLAST1978

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei1842PhosphoserineCombined sources1
Modified residuei1846PhosphothreonineCombined sources1
Modified residuei1891PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15643

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15643

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15643

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15643

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15643

PeptideAtlas

More...
PeptideAtlasi
Q15643

PRoteomics IDEntifications database

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PRIDEi
Q15643

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60680

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15643

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15643

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung. Isoform 1 and isoform 2 are expressed in articular chondrocytes (PubMed:30728324).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100815 Expressed in 199 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15643 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15643 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002570
HPA070684

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the active form of RAB2A (PubMed:25473115).

Interacts with IFT20 (PubMed:19112494). Binds RB1.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114732, 33 interactors

Database of interacting proteins

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DIPi
DIP-40357N

Protein interaction database and analysis system

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IntActi
Q15643, 37 interactors

Molecular INTeraction database

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MINTi
Q15643

STRING: functional protein association networks

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STRINGi
9606.ENSP00000267622

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q15643 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15643

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1774 – 1823GRIPPROSITE-ProRule annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 38Amphipatic lipid-packing sensor required for tethering of intra-Golgi vesicles1 PublicationAdd BLAST37
Regioni1017 – 1195Involved in RAB2A binding1 PublicationAdd BLAST179
Regioni1325 – 1599Involved in RAB2A binding1 PublicationAdd BLAST275

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili52 – 1773Sequence analysisAdd BLAST1722

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Extended rod-like protein with coiled-coil domains.
The C-terminus is required for recruitment to the Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IF24 Eukaryota
ENOG410XT0E LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00710000106769

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000168282

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15643

KEGG Orthology (KO)

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KOi
K23368

Identification of Orthologs from Complete Genome Data

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OMAi
EQMNATH

Database of Orthologous Groups

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OrthoDBi
153176at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15643

TreeFam database of animal gene trees

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TreeFami
TF351148

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000237 GRIP_dom

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50913 GRIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15643-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSWLGGLGS GLGQSLGQVG GSLASLTGQI SNFTKDMLME GTEEVEAELP
60 70 80 90 100
DSRTKEIEAI HAILRSENER LKKLCTDLEE KHEASEIQIK QQSTSYRNQL
110 120 130 140 150
QQKEVEISHL KARQIALQDQ LLKLQSAAQS VPSGAGVPAT TASSSFAYGI
160 170 180 190 200
SHHPSAFHDD DMDFGDIISS QQEINRLSNE VSRLESEVGH WRHIAQTSKA
210 220 230 240 250
QGTDNSDQSE ICKLQNIIKE LKQNRSQEID DHQHEMSVLQ NAHQQKLTEI
260 270 280 290 300
SRRHREELSD YEERIEELEN LLQQGGSGVI ETDLSKIYEM QKTIQVLQIE
310 320 330 340 350
KVESTKKMEQ LEDKIKDINK KLSSAENDRD ILRREQEQLN VEKRQIMEEC
360 370 380 390 400
ENLKLECSKL QPSAVKQSDT MTEKERILAQ SASVEEVFRL QQALSDAENE
410 420 430 440 450
IMRLSSLNQD NSLAEDNLKL KMRIEVLEKE KSLLSQEKEE LQMSLLKLNN
460 470 480 490 500
EYEVIKSTAT RDISLDSELH DLRLNLEAKE QELNQSISEK ETLIAEIEEL
510 520 530 540 550
DRQNQEATKH MILIKDQLSK QQNEGDSIIS KLKQDLNDEK KRVHQLEDDK
560 570 580 590 600
MDITKELDVQ KEKLIQSEVA LNDLHLTKQK LEDKVENLVD QLNKSQESNV
610 620 630 640 650
SIQKENLELK EHIRQNEEEL SRIRNELMQS LNQDSNSNFK DTLLKEREAE
660 670 680 690 700
VRNLKQNLSE LEQLNENLKK VAFDVKMENE KLVLACEDVR HQLEECLAGN
710 720 730 740 750
NQLSLEKNTI VETLKMEKGE IEAELCWAKK RLLEEANKYE KTIEELSNAR
760 770 780 790 800
NLNTSALQLE HEHLIKLNQK KDMEIAELKK NIEQMDTDHK ETKDVLSSSL
810 820 830 840 850
EEQKQLTQLI NKKEIFIEKL KERSSKLQEE LDKYSQALRK NEILRQTIEE
860 870 880 890 900
KDRSLGSMKE ENNHLQEELE RLREEQSRTA PVADPKTLDS VTELASEVSQ
910 920 930 940 950
LNTIKEHLEE EIKHHQKIIE DQNQSKMQLL QSLQEQKKEM DEFRYQHEQM
960 970 980 990 1000
NATHTQLFLE KDEEIKSLQK TIEQIKTQLH EERQDIQTDN SDIFQETKVQ
1010 1020 1030 1040 1050
SLNIENGSEK HDLSKAETER LVKGIKEREL EIKLLNEKNI SLTKQIDQLS
1060 1070 1080 1090 1100
KDEVGKLTQI IQQKDLEIQA LHARISSTSH TQDVVYLQQQ LQAYAMEREK
1110 1120 1130 1140 1150
VFAVLNEKTR ENSHLKTEYH KMMDIVAAKE AALIKLQDEN KKLSTRFESS
1160 1170 1180 1190 1200
GQDMFRETIQ NLSRIIREKD IEIDALSQKC QTLLAVLQTS STGNEAGGVN
1210 1220 1230 1240 1250
SNQFEELLQE RDKLKQQVKK MEEWKQQVMT TVQNMQHESA QLQEELHQLQ
1260 1270 1280 1290 1300
AQVLVDSDNN SKLQVDYTGL IQSYEQNETK LKNFGQELAQ VQHSIGQLCN
1310 1320 1330 1340 1350
TKDLLLGKLD IISPQLSSAS LLTPQSAECL RASKSEVLSE SSELLQQELE
1360 1370 1380 1390 1400
ELRKSLQEKD ATIRTLQENN HRLSDSIAAT SELERKEHEQ TDSEIKQLKE
1410 1420 1430 1440 1450
KQDVLQKLLK EKDLLIKAKS DQLLSSNENF TNKVNENELL RQAVTNLKER
1460 1470 1480 1490 1500
ILILEMDIGK LKGENEKIVE TYRGKETEYQ ALQETNMKFS MMLREKEFEC
1510 1520 1530 1540 1550
HSMKEKALAF EQLLKEKEQG KTGELNQLLN AVKSMQEKTV VFQQERDQVM
1560 1570 1580 1590 1600
LALKQKQMEN TALQNEVQRL RDKEFRSNQE LERLRNHLLE SEDSYTREAL
1610 1620 1630 1640 1650
AAEDREAKLR KKVTVLEEKL VSSSNAMENA SHQASVQVES LQEQLNVVSK
1660 1670 1680 1690 1700
QRDETALQLS VSQEQVKQYA LSLANLQMVL EHFQQEEKAM YSAELEKQKQ
1710 1720 1730 1740 1750
LIAEWKKNAE NLEGKVISLQ ECLDEANAAL DSASRLTEQL DVKEEQIEEL
1760 1770 1780 1790 1800
KRQNELRQEM LDDVQKKLMS LANSSEGKVD KVLMRNLFIG HFHTPKNQRH
1810 1820 1830 1840 1850
EVLRLMGSIL GVRREEMEQL FHDDQGGVTR WMTGWLGGGS KSVPNTPLRP
1860 1870 1880 1890 1900
NQQSVVNSSF SELFVKFLET ESHPSIPPPK LSVHDMKPLD SPGRRKRDTN
1910 1920 1930 1940 1950
APESFKDTAE SRSGRRTDVN PFLAPRSAAV PLINPAGLGP GGPGHLLLKP
1960 1970
ISDVLPTFTP LPALPDNSAG VVLKDLLKQ
Length:1,979
Mass (Da):227,586
Last modified:March 23, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i437EB5F5966BB1AE
GO
Isoform 2 (identifier: Q15643-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-438: Missing.

Show »
Length:1,950
Mass (Da):224,202
Checksum:iA0BC280A32B35B61
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJ97H0YJ97_HUMAN
Thyroid receptor-interacting protei...
TRIP11
1,695Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4R7G3V4R7_HUMAN
Thyroid receptor-interacting protei...
TRIP11
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJI2H0YJI2_HUMAN
Thyroid receptor-interacting protei...
TRIP11
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB84386 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121L → F in AAD09135 (PubMed:9256431).Curated1
Sequence conflicti382A → G in AAD09135 (PubMed:9256431).Curated1
Sequence conflicti391Q → R in AAD09135 (PubMed:9256431).Curated1
Sequence conflicti516D → A in AAD09135 (PubMed:9256431).Curated1
Sequence conflicti561 – 563KEK → FVL in AAD09135 (PubMed:9256431).Curated3
Sequence conflicti1202N → H (PubMed:10189370).Curated1
Sequence conflicti1213K → T in CAE46015 (PubMed:17974005).Curated1
Sequence conflicti1237H → R in AAB84386 (PubMed:9373237).Curated1
Sequence conflicti1346 – 1347QQ → HE in AAB84386 (PubMed:9373237).Curated2
Sequence conflicti1566E → V in CAE46015 (PubMed:17974005).Curated1
Sequence conflicti1658 – 1665QLSVSQEQ → RFCLSGT in AAD09135 (PubMed:9256431).Curated8
Sequence conflicti1670A → R in AAD09135 (PubMed:9256431).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05586139M → L1 PublicationCorresponds to variant dbSNP:rs17127898EnsemblClinVar.1
Natural variantiVAR_082008105 – 196Missing in ODCD; in-frame exon 4 skipping; due to a nucleotide substitution that may also cause protein truncation. 1 PublicationAdd BLAST92
Natural variantiVAR_082009196 – 1979Missing in ODCD; due to a nucleotide substitution that causes protein truncation or in-frame exon 4 skipping. 1 PublicationAdd BLAST1784
Natural variantiVAR_082010264 – 1979Missing in ACG1A and ODCD. 2 PublicationsAdd BLAST1716
Natural variantiVAR_082011410D → Y in ODCD; due to a nucleotide substitution that causes in-frame exon 9 skipping or results in missense variant Y-410; patient cells contain both type of transcripts; the transcript lacking exon 9 is the most abundant. 1 Publication1
Natural variantiVAR_055862506E → A. Corresponds to variant dbSNP:rs2273186EnsemblClinVar.1
Natural variantiVAR_079175559V → A1 Publication1
Natural variantiVAR_055863795V → L. Corresponds to variant dbSNP:rs34699762EnsemblClinVar.1
Natural variantiVAR_055864884D → G. Corresponds to variant dbSNP:rs34967261EnsemblClinVar.1
Natural variantiVAR_0558651040I → V. Corresponds to variant dbSNP:rs34805848EnsemblClinVar.1
Natural variantiVAR_0603441107E → D. Corresponds to variant dbSNP:rs4619320Ensembl.1
Natural variantiVAR_0820121160 – 1979Missing in ACG1A. 1 PublicationAdd BLAST820
Natural variantiVAR_0822851167 – 1979Missing in ACG1A. 1 PublicationAdd BLAST813
Natural variantiVAR_0820131224 – 1979Missing in ACG1A; does not localize to cis-Golgi; results in disruption of Golgi cisternal stack architecture. 1 PublicationAdd BLAST756
Natural variantiVAR_0820141321 – 1979Missing in ACG1A. 1 PublicationAdd BLAST659
Natural variantiVAR_0820151376 – 1979Missing in ACG1A. 1 PublicationAdd BLAST604
Natural variantiVAR_0603451413D → A. Corresponds to variant dbSNP:rs12884523Ensembl.1
Natural variantiVAR_0558661503M → V. Corresponds to variant dbSNP:rs34839498EnsemblClinVar.1
Natural variantiVAR_0820161512 – 1979Missing in ODCD. 1 PublicationAdd BLAST468
Natural variantiVAR_0558671576R → H. Corresponds to variant dbSNP:rs35007347EnsemblClinVar.1
Natural variantiVAR_0558681749E → A. Corresponds to variant dbSNP:rs2273183EnsemblClinVar.1
Natural variantiVAR_0558691752R → K. Corresponds to variant dbSNP:rs11851376EnsemblClinVar.1
Natural variantiVAR_0820171806M → V in ODCD; due to a nucleotide substitution that causes missplicing of exon 18 or results in missense variant V-1806; patient cells contain both type of transcripts; the transcript with the missense variant is the most abundant. 1 Publication1
Natural variantiVAR_0603461827G → S4 PublicationsCorresponds to variant dbSNP:rs1051340EnsemblClinVar.1
Natural variantiVAR_0541511846T → I1 PublicationCorresponds to variant dbSNP:rs141259390EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060242410 – 438Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF007217 mRNA Translation: AAD09135.1
Y12490 mRNA Translation: CAA73095.1
AL049872 Genomic DNA No translation available.
BC146845 mRNA Translation: AAI46846.1
BX641024 mRNA Translation: CAE46015.1
AF011368 mRNA Translation: AAB84386.1 Frameshift.
L40380 mRNA Translation: AAC41730.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9899.1 [Q15643-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T03719

NCBI Reference Sequences

More...
RefSeqi
NP_004230.2, NM_004239.4 [Q15643-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267622; ENSP00000267622; ENSG00000100815 [Q15643-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9321

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9321

UCSC genome browser

More...
UCSCi
uc001xzy.4 human [Q15643-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007217 mRNA Translation: AAD09135.1
Y12490 mRNA Translation: CAA73095.1
AL049872 Genomic DNA No translation available.
BC146845 mRNA Translation: AAI46846.1
BX641024 mRNA Translation: CAE46015.1
AF011368 mRNA Translation: AAB84386.1 Frameshift.
L40380 mRNA Translation: AAC41730.1 Sequence problems.
CCDSiCCDS9899.1 [Q15643-1]
PIRiT03719
RefSeqiNP_004230.2, NM_004239.4 [Q15643-1]

3D structure databases

SMRiQ15643
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114732, 33 interactors
DIPiDIP-40357N
IntActiQ15643, 37 interactors
MINTiQ15643
STRINGi9606.ENSP00000267622

PTM databases

iPTMnetiQ15643
PhosphoSitePlusiQ15643

Polymorphism and mutation databases

BioMutaiTRIP11
DMDMi292495059

Proteomic databases

EPDiQ15643
jPOSTiQ15643
MassIVEiQ15643
MaxQBiQ15643
PaxDbiQ15643
PeptideAtlasiQ15643
PRIDEiQ15643
ProteomicsDBi60680

Genome annotation databases

EnsembliENST00000267622; ENSP00000267622; ENSG00000100815 [Q15643-1]
GeneIDi9321
KEGGihsa:9321
UCSCiuc001xzy.4 human [Q15643-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9321
DisGeNETi9321
EuPathDBiHostDB:ENSG00000100815.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIP11
HGNCiHGNC:12305 TRIP11
HPAiHPA002570
HPA070684
MalaCardsiTRIP11
MIMi184260 phenotype
200600 phenotype
604505 gene
neXtProtiNX_Q15643
OpenTargetsiENSG00000100815
Orphaneti93299 Achondrogenesis type 1A
166272 Odontochondrodysplasia
PharmGKBiPA36984

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF24 Eukaryota
ENOG410XT0E LUCA
GeneTreeiENSGT00710000106769
HOGENOMiHOG000168282
InParanoidiQ15643
KOiK23368
OMAiEQMNATH
OrthoDBi153176at2759
PhylomeDBiQ15643
TreeFamiTF351148

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport
R-HSA-6811438 Intra-Golgi traffic
SIGNORiQ15643

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRIP11 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRIP11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9321
PharosiQ15643 Tbio

Protein Ontology

More...
PROi
PR:Q15643
RNActiQ15643 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100815 Expressed in 199 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ15643 baseline and differential
GenevisibleiQ15643 HS

Family and domain databases

InterProiView protein in InterPro
IPR000237 GRIP_dom
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIPB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15643
Secondary accession number(s): B2RUT2
, O14689, O15154, O95949, Q6MZL5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: December 11, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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