UniProtKB - Q15642 (CIP4_HUMAN)
Cdc42-interacting protein 4
TRIP10
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 166 | Mediates end-to-end attachment of dimers | 1 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- lipid binding Source: UniProtKB-KW
GO - Biological processi
- actin cytoskeleton organization Source: UniProtKB
- cell communication Source: UniProtKB
- endocytosis Source: UniProtKB-KW
- membrane organization Source: Reactome
- regulation of small GTPase mediated signal transduction Source: Reactome
- signal transduction Source: ProtInc
Keywordsi
Biological process | Endocytosis |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q15642 |
Reactomei | R-HSA-194840, Rho GTPase cycle R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | Q15642 |
SIGNORi | Q15642 |
Names & Taxonomyi
Protein namesi | Recommended name: Cdc42-interacting protein 4Alternative name(s): Protein Felic Salt tolerant protein Short name: hSTP Thyroid receptor-interacting protein 10 Short name: TR-interacting protein 10 Short name: TRIP-10 |
Gene namesi | Name:TRIP10 Synonyms:CIP4, STOT, STP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000125733.17 |
HGNCi | HGNC:12304, TRIP10 |
MIMi | 604504, gene |
neXtProti | NX_Q15642 |
Subcellular locationi
Plasma membrane
Cytoskeleton
Golgi apparatus
Lysosome
Other locations
Note: Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.By similarity
Other locations
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Lysosome
- lysosome Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- phagocytic cup Source: UniProtKB-SubCell
Other locations
- cell cortex Source: UniProtKB-SubCell
- cell projection Source: UniProtKB-KW
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Lysosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 454 | I → S: Abrogates interaction with CDC42. 1 Publication | 1 | |
Mutagenesisi | 468 | L → S: Impairs interaction with CDC42. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9322 |
OpenTargetsi | ENSG00000125733 |
PharmGKBi | PA36983 |
Miscellaneous databases
Pharosi | Q15642, Tbio |
Polymorphism and mutation databases
BioMutai | TRIP10 |
DMDMi | 118572632 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089766 | 1 – 601 | Cdc42-interacting protein 4Add BLAST | 601 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 296 | PhosphoserineCombined sources | 1 | |
Modified residuei | 298 | PhosphoserineCombined sources | 1 | |
Modified residuei | 299 | PhosphoserineCombined sources | 1 | |
Modified residuei | 335 | PhosphoserineCombined sources | 1 | |
Modified residuei | 351 | PhosphoserineCombined sources | 1 | |
Modified residuei | 482 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15642 |
jPOSTi | Q15642 |
MassIVEi | Q15642 |
MaxQBi | Q15642 |
PeptideAtlasi | Q15642 |
PRIDEi | Q15642 |
ProteomicsDBi | 60675 [Q15642-1] 60676 [Q15642-2] 60677 [Q15642-3] 60678 [Q15642-4] 60679 [Q15642-5] |
PTM databases
iPTMneti | Q15642 |
MetOSitei | Q15642 |
PhosphoSitePlusi | Q15642 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000125733, Expressed in lower esophagus mucosa and 218 other tissues |
ExpressionAtlasi | Q15642, baseline and differential |
Genevisiblei | Q15642, HS |
Organism-specific databases
HPAi | ENSG00000125733, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Interacts specifically with GTP-bound RHOQ.
Interacts with DNM2 and PDE6G (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures.
Interacts specifically with GTP-bound CDC42.
Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP and WASL/N-WASP.
Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT.
By similarity11 PublicationsBinary interactionsi
Hide detailsQ15642
Isoform 1 [Q15642-1]
With | #Exp. | IntAct |
---|---|---|
Inpp5d [P97573] from Rattus norvegicus. | 2 | EBI-16191375,EBI-8008869 |
TRIP10 - isoform 2 [Q15642-2]
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 114733, 67 interactors |
DIPi | DIP-39840N |
IntActi | Q15642, 51 interactors |
MINTi | Q15642 |
STRINGi | 9606.ENSP00000320117 |
Miscellaneous databases
RNActi | Q15642, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q15642 |
SMRi | Q15642 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15642 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 264 | F-BARPROSITE-ProRule annotationAdd BLAST | 264 | |
Domaini | 393 – 470 | REM-1PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 540 – 601 | SH3PROSITE-ProRule annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 117 | Required for podosome formation and interaction with AKAP9 and microtubules1 PublicationAdd BLAST | 117 | |
Regioni | 1 – 117 | Required for translocation to the plasma membrane in response to insulinBy similarityAdd BLAST | 117 | |
Regioni | 293 – 601 | Interaction with PDE6GBy similarityAdd BLAST | 309 | |
Regioni | 293 – 537 | Interaction with CDC42Add BLAST | 245 | |
Regioni | 471 – 601 | Required for interaction with FASLG and localization to lysosomes1 PublicationAdd BLAST | 131 | |
Regioni | 487 – 541 | Interaction with DNM2 and WASLBy similarityAdd BLAST | 55 | |
Regioni | 529 – 601 | Interaction with DNM1 and WASL1 PublicationAdd BLAST | 73 | |
Regioni | 538 – 601 | Required for podosome formationAdd BLAST | 64 | |
Regioni | 544 – 601 | Interaction with WAS1 PublicationAdd BLAST | 58 | |
Regioni | 546 – 601 | Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH22 PublicationsAdd BLAST | 56 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 67 – 259 | Add BLAST | 193 | |
Coiled coili | 388 – 481 | Add BLAST | 94 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG3565, Eukaryota |
GeneTreei | ENSGT00950000183047 |
HOGENOMi | CLU_023320_1_0_1 |
InParanoidi | Q15642 |
OMAi | QERKTHF |
OrthoDBi | 348563at2759 |
PhylomeDBi | Q15642 |
TreeFami | TF351162 |
Family and domain databases
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR028498, CIP4 IPR031160, F_BAR IPR001060, FCH_dom IPR011072, HR1_rho-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR15735:SF17, PTHR15735:SF17, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS51860, REM_1, 1 hit PS50002, SH3, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDWGTELWDQ FEVLERHTQW GLDLLDRYVK FVKERTEVEQ AYAKQLRSLV
60 70 80 90 100
KKYLPKRPAK DDPESKFSQQ QSFVQILQEV NDFAGQRELV AENLSVRVCL
110 120 130 140 150
ELTKYSQEMK QERKMHFQEG RRAQQQLENG FKQLENSKRK FERDCREAEK
160 170 180 190 200
AAQTAERLDQ DINATKADVE KAKQQAHLRS HMAEESKNEY AAQLQRFNRD
210 220 230 240 250
QAHFYFSQMP QIFDKLQDMD ERRATRLGAG YGLLSEAELE VVPIIAKCLE
260 270 280 290 300
GMKVAANAVD PKNDSHVLIE LHKSGFARPG DVEFEDFSQP MNRAPSDSSL
310 320 330 340 350
GTPSDGRPEL RGPGRSRTKR WPFGKKNKPR PPPLSPLGGP VPSALPNGPP
360 370 380 390 400
SPRSGRDPLA ILSEISKSVK PRLASFRSLR GSRGTVVTED FSHLPPEQQR
410 420 430 440 450
KRLQQQLEER SRELQKEVDQ REALKKMKDV YEKTPQMGDP ASLEPQIAET
460 470 480 490 500
LSNIERLKLE VQKYEAWLAE AESRVLSNRG DSLSRHARPP DPPASAPPDS
510 520 530 540 550
SSNSASQDTK ESSEEPPSEE SQDTPIYTEF DEDFEEEPTS PIGHCVAIYH
560 570 580 590 600
FEGSSEGTIS MAEGEDLSLM EEDKGDGWTR VRRKEGGEGY VPTSYLRVTL
N
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketW4VSQ9 | W4VSQ9_HUMAN | Cdc42-interacting protein 4 | TRIP10 hCG_23056 | 593 | Annotation score: | ||
M0R0F9 | M0R0F9_HUMAN | Cdc42-interacting protein 4 | TRIP10 | 437 | Annotation score: | ||
M0R2H7 | M0R2H7_HUMAN | Cdc42-interacting protein 4 | TRIP10 | 343 | Annotation score: | ||
M0R070 | M0R070_HUMAN | Cdc42-interacting protein 4 | TRIP10 | 83 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 158 | L → P in AAK77492 (PubMed:12054674).Curated | 1 | |
Sequence conflicti | 310 | L → P in AAK77492 (PubMed:12054674).Curated | 1 | |
Sequence conflicti | 419 | D → G in BAD96829 (Ref. 8) Curated | 1 | |
Sequence conflicti | 440 | P → S in BAD96829 (Ref. 8) Curated | 1 | |
Sequence conflicti | 473 | S → R in AAK77492 (PubMed:12054674).Curated | 1 | |
Sequence conflicti | 487 – 499 | ARPPD…SAPPD → KHPIICRLIHFSN in AAC41729 (Ref. 10) CuratedAdd BLAST | 13 | |
Sequence conflicti | 553 | G → W in CAG38751 (Ref. 5) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021716 | 329 – 384 | Missing in isoform 2, isoform 3 and isoform 4. 7 PublicationsAdd BLAST | 56 | |
Alternative sequenceiVSP_021717 | 330 – 341 | RPPPL…LGGPV → SRQPWDSGDRGF in isoform 5. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_021718 | 342 – 601 | Missing in isoform 5. 1 PublicationAdd BLAST | 260 | |
Alternative sequenceiVSP_021719 | 512 | S → R in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_021720 | 513 – 601 | Missing in isoform 4. 1 PublicationAdd BLAST | 89 | |
Alternative sequenceiVSP_021721 | 553 – 601 | GSSEG…RVTLN → DLGPPPPPSQGPARALSLWP RVKTSVLWKKTKGTAGPGSG GKREARATCPPPTSESRSIE PCQRREEGGCRLLLLGHGGS QDLGTLFLTPWLRLRPV in isoform 3. 1 PublicationAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ000414 mRNA Translation: CAA04062.1 AF380114 mRNA Translation: AAK77492.1 AY081141 mRNA Translation: AAL89588.1 AB072596 mRNA Translation: BAB88853.1 AF502289 mRNA Translation: AAM46851.1 CR536513 mRNA Translation: CAG38751.1 BT006698 mRNA Translation: AAP35344.1 BT020167 mRNA Translation: AAV38969.1 BT020171 mRNA Translation: AAV43773.1 AK223109 mRNA Translation: BAD96829.1 AK313296 mRNA Translation: BAG36103.1 AC008760 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69065.1 CH471139 Genomic DNA Translation: EAW69062.1 CH471139 Genomic DNA Translation: EAW69063.1 BC013002 mRNA Translation: AAH13002.1 L40379 mRNA Translation: AAC41729.1 |
CCDSi | CCDS12172.1 [Q15642-2] CCDS74271.1 [Q15642-1] CCDS74272.1 [Q15642-3] |
RefSeqi | NP_001275891.1, NM_001288962.1 [Q15642-1] NP_001275892.1, NM_001288963.1 NP_004231.1, NM_004240.3 [Q15642-2] |
Genome annotation databases
Ensembli | ENST00000313244; ENSP00000320117; ENSG00000125733 [Q15642-1] ENST00000313285; ENSP00000320493; ENSG00000125733 [Q15642-2] |
GeneIDi | 9322 |
KEGGi | hsa:9322 |
UCSCi | uc002mfr.5, human [Q15642-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ000414 mRNA Translation: CAA04062.1 AF380114 mRNA Translation: AAK77492.1 AY081141 mRNA Translation: AAL89588.1 AB072596 mRNA Translation: BAB88853.1 AF502289 mRNA Translation: AAM46851.1 CR536513 mRNA Translation: CAG38751.1 BT006698 mRNA Translation: AAP35344.1 BT020167 mRNA Translation: AAV38969.1 BT020171 mRNA Translation: AAV43773.1 AK223109 mRNA Translation: BAD96829.1 AK313296 mRNA Translation: BAG36103.1 AC008760 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69065.1 CH471139 Genomic DNA Translation: EAW69062.1 CH471139 Genomic DNA Translation: EAW69063.1 BC013002 mRNA Translation: AAH13002.1 L40379 mRNA Translation: AAC41729.1 |
CCDSi | CCDS12172.1 [Q15642-2] CCDS74271.1 [Q15642-1] CCDS74272.1 [Q15642-3] |
RefSeqi | NP_001275891.1, NM_001288962.1 [Q15642-1] NP_001275892.1, NM_001288963.1 NP_004231.1, NM_004240.3 [Q15642-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CT4 | NMR | - | A | 543-599 | [»] | |
2EFK | X-ray | 2.30 | A | 10-303 | [»] | |
2KE4 | NMR | - | A | 388-481 | [»] | |
BMRBi | Q15642 | |||||
SMRi | Q15642 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114733, 67 interactors |
DIPi | DIP-39840N |
IntActi | Q15642, 51 interactors |
MINTi | Q15642 |
STRINGi | 9606.ENSP00000320117 |
PTM databases
iPTMneti | Q15642 |
MetOSitei | Q15642 |
PhosphoSitePlusi | Q15642 |
Polymorphism and mutation databases
BioMutai | TRIP10 |
DMDMi | 118572632 |
Proteomic databases
EPDi | Q15642 |
jPOSTi | Q15642 |
MassIVEi | Q15642 |
MaxQBi | Q15642 |
PeptideAtlasi | Q15642 |
PRIDEi | Q15642 |
ProteomicsDBi | 60675 [Q15642-1] 60676 [Q15642-2] 60677 [Q15642-3] 60678 [Q15642-4] 60679 [Q15642-5] |
Protocols and materials databases
Antibodypediai | 11922, 244 antibodies |
DNASUi | 9322 |
Genome annotation databases
Ensembli | ENST00000313244; ENSP00000320117; ENSG00000125733 [Q15642-1] ENST00000313285; ENSP00000320493; ENSG00000125733 [Q15642-2] |
GeneIDi | 9322 |
KEGGi | hsa:9322 |
UCSCi | uc002mfr.5, human [Q15642-1] |
Organism-specific databases
CTDi | 9322 |
DisGeNETi | 9322 |
EuPathDBi | HostDB:ENSG00000125733.17 |
GeneCardsi | TRIP10 |
HGNCi | HGNC:12304, TRIP10 |
HPAi | ENSG00000125733, Tissue enhanced (skeletal) |
MIMi | 604504, gene |
neXtProti | NX_Q15642 |
OpenTargetsi | ENSG00000125733 |
PharmGKBi | PA36983 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3565, Eukaryota |
GeneTreei | ENSGT00950000183047 |
HOGENOMi | CLU_023320_1_0_1 |
InParanoidi | Q15642 |
OMAi | QERKTHF |
OrthoDBi | 348563at2759 |
PhylomeDBi | Q15642 |
TreeFami | TF351162 |
Enzyme and pathway databases
PathwayCommonsi | Q15642 |
Reactomei | R-HSA-194840, Rho GTPase cycle R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | Q15642 |
SIGNORi | Q15642 |
Miscellaneous databases
BioGRID-ORCSi | 9322, 4 hits in 844 CRISPR screens |
ChiTaRSi | TRIP10, human |
EvolutionaryTracei | Q15642 |
GeneWikii | TRIP10 |
GenomeRNAii | 9322 |
Pharosi | Q15642, Tbio |
PROi | PR:Q15642 |
RNActi | Q15642, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125733, Expressed in lower esophagus mucosa and 218 other tissues |
ExpressionAtlasi | Q15642, baseline and differential |
Genevisiblei | Q15642, HS |
Family and domain databases
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR028498, CIP4 IPR031160, F_BAR IPR001060, FCH_dom IPR011072, HR1_rho-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR15735:SF17, PTHR15735:SF17, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS51860, REM_1, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CIP4_HUMAN | |
Accessioni | Q15642Primary (citable) accession number: Q15642 Secondary accession number(s): B2R8A6 Q96RJ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 28, 2006 | |
Last modified: | December 2, 2020 | |
This is version 198 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM