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UniProtKB - Q15642 (CIP4_HUMAN)

Entry version 199 (10 Feb 2021)
Sequence version 3 (28 Nov 2006)
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Protein

Cdc42-interacting protein 4

Gene

TRIP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei166Mediates end-to-end attachment of dimers1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • cell communication Source: UniProtKB
  • endocytosis Source: UniProtKB-KW
  • membrane organization Source: Reactome
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15642

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-194840, Rho GTPase cycle
R-HSA-8856828, Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15642

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15642

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cdc42-interacting protein 4
Alternative name(s):
Protein Felic
Salt tolerant protein
Short name:
hSTP
Thyroid receptor-interacting protein 10
Short name:
TR-interacting protein 10
Short name:
TRIP-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIP10
Synonyms:CIP4, STOT, STP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12304, TRIP10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604504, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15642

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000125733.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi454I → S: Abrogates interaction with CDC42. 1 Publication1
Mutagenesisi468L → S: Impairs interaction with CDC42. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9322

Open Targets

More...OpenTargetsi		ENSG00000125733

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36983

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15642, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIP10

Domain mapping of disease mutations (DMDM)

More...DMDMi		118572632

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897661 – 601Cdc42-interacting protein 4Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei296PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei482PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated. Also phosphorylated by PKA.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15642

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15642

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15642

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15642

PeptideAtlas

More...PeptideAtlasi		Q15642

PRoteomics IDEntifications database

More...PRIDEi		Q15642

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60675 [Q15642-1]
60676 [Q15642-2]
60677 [Q15642-3]
60678 [Q15642-4]
60679 [Q15642-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15642

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q15642

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15642

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.5 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by adriamycin treatment and this effect is counteracted by HGF/SF. Expression is reduced during differentiation.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125733, Expressed in lower esophagus mucosa and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15642, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15642, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125733, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts specifically with GTP-bound RHOQ.

Interacts with DNM2 and PDE6G (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures.

Interacts specifically with GTP-bound CDC42.

Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP and WASL/N-WASP.

Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT.

By similarity11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q15642
With#Exp.IntAct
ADAM8 [P78325]2EBI-739936,EBI-2625954
ARHGAP12 [Q1RLN5]3EBI-739936,EBI-3959665
ARHGAP17 [Q68EM7]3EBI-739936,EBI-1642807
ARHGAP44 - isoform 2 [Q17R89-2]3EBI-739936,EBI-10238335
FASLG [P48023]4EBI-739936,EBI-495538
RHOJ [Q9H4E5]3EBI-739936,EBI-6285694
SH3BP1 [Q9Y3L3]3EBI-739936,EBI-346869
SMARCE1 [Q969G3]3EBI-739936,EBI-455078
TINF2 [Q9BSI4]2EBI-739936,EBI-717399
itself4EBI-739936,EBI-739936
WASF1 [Q92558]3EBI-739936,EBI-1548747
Isoform 1 [Q15642-1]
With#Exp.IntAct
Inpp5d [P97573] from Rattus norvegicus.2EBI-16191375,EBI-8008869
TRIP10 - isoform 2 [Q15642-2]
With#Exp.IntAct
ABI1 - isoform 5 [Q8IZP0-5]3EBI-6550597,EBI-11743294
ABL2 - isoform 3 [P42684-3]3EBI-6550597,EBI-10693977
ARHGAP12 - isoform 4 [Q8IWW6-4]3EBI-6550597,EBI-11959591
ARHGAP17 [Q68EM7]3EBI-6550597,EBI-1642807
DAAM1 [Q9Y4D1]2EBI-6550597,EBI-2817289
DTX3 [Q8N9I9]3EBI-6550597,EBI-2340258
HOXC11 [O43248]3EBI-6550597,EBI-2652631
HTT [P42858]18EBI-6550597,EBI-466029
JRK - isoform 2 [O75564-2]3EBI-6550597,EBI-17181882
MEOX1 [P50221]3EBI-6550597,EBI-2864512
MEOX2 [Q6FHY5]3EBI-6550597,EBI-16439278
NKX2-5 [P52952]3EBI-6550597,EBI-936601
PAX6 [P26367]3EBI-6550597,EBI-747278
RIN1 [Q13671]3EBI-6550597,EBI-366017
SF3A2 [Q15428]3EBI-6550597,EBI-2462271
SH3BP1 [Q9Y3L3]3EBI-6550597,EBI-346869
SMARCE1 [Q969G3]6EBI-6550597,EBI-455078
THAP1 [Q9NVV9]3EBI-6550597,EBI-741515
itself3EBI-6550597,EBI-6550597
UTF1 [Q5T230]3EBI-6550597,EBI-12927594
WASF1 [Q92558]3EBI-6550597,EBI-1548747
WASL [O00401]5EBI-6550597,EBI-957615
ZBTB7B - isoform 2 [O15156-2]3EBI-6550597,EBI-11522250

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114733, 68 interactors

Database of interacting proteins

More...DIPi		DIP-39840N

Protein interaction database and analysis system

More...IntActi		Q15642, 52 interactors

Molecular INTeraction database

More...MINTi		Q15642

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000320117

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15642, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1601
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q15642

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15642

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15642

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 264F-BARPROSITE-ProRule annotationAdd BLAST264
Domaini393 – 470REM-1PROSITE-ProRule annotationAdd BLAST78
Domaini540 – 601SH3PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 117Required for podosome formation and interaction with AKAP9 and microtubules1 PublicationAdd BLAST117
Regioni1 – 117Required for translocation to the plasma membrane in response to insulinBy similarityAdd BLAST117
Regioni293 – 601Interaction with PDE6GBy similarityAdd BLAST309
Regioni293 – 537Interaction with CDC42Add BLAST245
Regioni471 – 601Required for interaction with FASLG and localization to lysosomes1 PublicationAdd BLAST131
Regioni487 – 541Interaction with DNM2 and WASLBy similarityAdd BLAST55
Regioni529 – 601Interaction with DNM1 and WASL1 PublicationAdd BLAST73
Regioni538 – 601Required for podosome formationAdd BLAST64
Regioni544 – 601Interaction with WAS1 PublicationAdd BLAST58
Regioni546 – 601Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH22 PublicationsAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili67 – 259Add BLAST193
Coiled coili388 – 481Add BLAST94

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FNBP1 family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3565, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183047

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023320_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15642

Identification of Orthologs from Complete Genome Data

More...OMAi		QERKTHF

Database of Orthologous Groups

More...OrthoDBi		348563at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15642

TreeFam database of animal gene trees

More...TreeFami		TF351162

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR028498, CIP4
IPR031160, F_BAR
IPR001060, FCH_dom
IPR011072, HR1_rho-bd
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...PANTHERi		PTHR15735:SF17, PTHR15735:SF17, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00611, FCH, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00055, FCH, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103657, SSF103657, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51741, F_BAR, 1 hit
PS51860, REM_1, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15642-1) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDWGTELWDQ FEVLERHTQW GLDLLDRYVK FVKERTEVEQ AYAKQLRSLV 
        60         70         80         90        100
KKYLPKRPAK DDPESKFSQQ QSFVQILQEV NDFAGQRELV AENLSVRVCL 
       110        120        130        140        150
ELTKYSQEMK QERKMHFQEG RRAQQQLENG FKQLENSKRK FERDCREAEK 
       160        170        180        190        200
AAQTAERLDQ DINATKADVE KAKQQAHLRS HMAEESKNEY AAQLQRFNRD 
       210        220        230        240        250
QAHFYFSQMP QIFDKLQDMD ERRATRLGAG YGLLSEAELE VVPIIAKCLE 
       260        270        280        290        300
GMKVAANAVD PKNDSHVLIE LHKSGFARPG DVEFEDFSQP MNRAPSDSSL 
       310        320        330        340        350
GTPSDGRPEL RGPGRSRTKR WPFGKKNKPR PPPLSPLGGP VPSALPNGPP 
       360        370        380        390        400
SPRSGRDPLA ILSEISKSVK PRLASFRSLR GSRGTVVTED FSHLPPEQQR 
       410        420        430        440        450
KRLQQQLEER SRELQKEVDQ REALKKMKDV YEKTPQMGDP ASLEPQIAET 
       460        470        480        490        500
LSNIERLKLE VQKYEAWLAE AESRVLSNRG DSLSRHARPP DPPASAPPDS 
       510        520        530        540        550
SSNSASQDTK ESSEEPPSEE SQDTPIYTEF DEDFEEEPTS PIGHCVAIYH 
       560        570        580        590        600
FEGSSEGTIS MAEGEDLSLM EEDKGDGWTR VRRKEGGEGY VPTSYLRVTL 

N
Length:601
Mass (Da):68,352
Last modified:November 28, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9BFE85520C7ABC5
GO
Isoform 2 (identifier: Q15642-2) [UniParc]FASTAAdd to basket
Also known as: A, W

The sequence of this isoform differs from the canonical sequence as follows:
     329-384: Missing.

Show »
Length:545
Mass (Da):62,592
Checksum:i9C9D72EA734BC6E2
GO
Isoform 3 (identifier: Q15642-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     329-384: Missing.
     553-601: GSSEGTISMA...PTSYLRVTLN → DLGPPPPPSQ...LTPWLRLRPV

Show »
Length:593
Mass (Da):67,603
Checksum:i888A0FE78B42428B
GO
Isoform 4 (identifier: Q15642-4) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     329-384: Missing.
     512-512: S → R
     513-601: Missing.

Show »
Length:456
Mass (Da):52,700
Checksum:iDBB2D486BC96832A
GO
Isoform 5 (identifier: Q15642-5) [UniParc]FASTAAdd to basket
Also known as: V

The sequence of this isoform differs from the canonical sequence as follows:
     330-341: RPPPLSPLGGPV → SRQPWDSGDRGF
     342-601: Missing.

Show »
Length:341
Mass (Da):39,583
Checksum:iA9568C38795E2E1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
W4VSQ9W4VSQ9_HUMAN
Cdc42-interacting protein 4
TRIP10 hCG_23056
593Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0F9M0R0F9_HUMAN
Cdc42-interacting protein 4
TRIP10
437Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2H7M0R2H7_HUMAN
Cdc42-interacting protein 4
TRIP10
343Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R070M0R070_HUMAN
Cdc42-interacting protein 4
TRIP10
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti158L → P in AAK77492 (PubMed:12054674).Curated1
Sequence conflicti310L → P in AAK77492 (PubMed:12054674).Curated1
Sequence conflicti419D → G in BAD96829 (Ref. 8) Curated1
Sequence conflicti440P → S in BAD96829 (Ref. 8) Curated1
Sequence conflicti473S → R in AAK77492 (PubMed:12054674).Curated1
Sequence conflicti487 – 499ARPPD…SAPPD → KHPIICRLIHFSN in AAC41729 (Ref. 10) CuratedAdd BLAST13
Sequence conflicti553G → W in CAG38751 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021716329 – 384Missing in isoform 2, isoform 3 and isoform 4. 7 PublicationsAdd BLAST56
Alternative sequenceiVSP_021717330 – 341RPPPL…LGGPV → SRQPWDSGDRGF in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_021718342 – 601Missing in isoform 5. 1 PublicationAdd BLAST260
Alternative sequenceiVSP_021719512S → R in isoform 4. 1 Publication1
Alternative sequenceiVSP_021720513 – 601Missing in isoform 4. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_021721553 – 601GSSEG…RVTLN → DLGPPPPPSQGPARALSLWP RVKTSVLWKKTKGTAGPGSG GKREARATCPPPTSESRSIE PCQRREEGGCRLLLLGHGGS QDLGTLFLTPWLRLRPV in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ000414 mRNA Translation: CAA04062.1
AF380114 mRNA Translation: AAK77492.1
AY081141 mRNA Translation: AAL89588.1
AB072596 mRNA Translation: BAB88853.1
AF502289 mRNA Translation: AAM46851.1
CR536513 mRNA Translation: CAG38751.1
BT006698 mRNA Translation: AAP35344.1
BT020167 mRNA Translation: AAV38969.1
BT020171 mRNA Translation: AAV43773.1
AK223109 mRNA Translation: BAD96829.1
AK313296 mRNA Translation: BAG36103.1
AC008760 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69065.1
CH471139 Genomic DNA Translation: EAW69062.1
CH471139 Genomic DNA Translation: EAW69063.1
BC013002 mRNA Translation: AAH13002.1
L40379 mRNA Translation: AAC41729.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12172.1 [Q15642-2]
CCDS74271.1 [Q15642-1]
CCDS74272.1 [Q15642-3]

NCBI Reference Sequences

More...RefSeqi		NP_001275891.1, NM_001288962.1 [Q15642-1]
NP_001275892.1, NM_001288963.1
NP_004231.1, NM_004240.3 [Q15642-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313244; ENSP00000320117; ENSG00000125733 [Q15642-1]
ENST00000313285; ENSP00000320493; ENSG00000125733 [Q15642-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9322

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9322

UCSC genome browser

More...UCSCi		uc002mfr.5, human [Q15642-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000414 mRNA Translation: CAA04062.1
AF380114 mRNA Translation: AAK77492.1
AY081141 mRNA Translation: AAL89588.1
AB072596 mRNA Translation: BAB88853.1
AF502289 mRNA Translation: AAM46851.1
CR536513 mRNA Translation: CAG38751.1
BT006698 mRNA Translation: AAP35344.1
BT020167 mRNA Translation: AAV38969.1
BT020171 mRNA Translation: AAV43773.1
AK223109 mRNA Translation: BAD96829.1
AK313296 mRNA Translation: BAG36103.1
AC008760 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69065.1
CH471139 Genomic DNA Translation: EAW69062.1
CH471139 Genomic DNA Translation: EAW69063.1
BC013002 mRNA Translation: AAH13002.1
L40379 mRNA Translation: AAC41729.1
CCDSiCCDS12172.1 [Q15642-2]
CCDS74271.1 [Q15642-1]
CCDS74272.1 [Q15642-3]
RefSeqiNP_001275891.1, NM_001288962.1 [Q15642-1]
NP_001275892.1, NM_001288963.1
NP_004231.1, NM_004240.3 [Q15642-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CT4NMR-A543-599[»]
2EFKX-ray2.30A10-303[»]
2KE4NMR-A388-481[»]
BMRBiQ15642
SMRiQ15642
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114733, 68 interactors
DIPiDIP-39840N
IntActiQ15642, 52 interactors
MINTiQ15642
STRINGi9606.ENSP00000320117

PTM databases

iPTMnetiQ15642
MetOSiteiQ15642
PhosphoSitePlusiQ15642

Genetic variation databases

BioMutaiTRIP10
DMDMi118572632

Proteomic databases

EPDiQ15642
jPOSTiQ15642
MassIVEiQ15642
MaxQBiQ15642
PeptideAtlasiQ15642
PRIDEiQ15642
ProteomicsDBi60675 [Q15642-1]
60676 [Q15642-2]
60677 [Q15642-3]
60678 [Q15642-4]
60679 [Q15642-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11922, 244 antibodies

The DNASU plasmid repository

More...DNASUi		9322

Genome annotation databases

EnsembliENST00000313244; ENSP00000320117; ENSG00000125733 [Q15642-1]
ENST00000313285; ENSP00000320493; ENSG00000125733 [Q15642-2]
GeneIDi9322
KEGGihsa:9322
UCSCiuc002mfr.5, human [Q15642-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9322
DisGeNETi9322

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIP10
HGNCiHGNC:12304, TRIP10
HPAiENSG00000125733, Tissue enhanced (skeletal)
MIMi604504, gene
neXtProtiNX_Q15642
OpenTargetsiENSG00000125733
PharmGKBiPA36983
VEuPathDBiHostDB:ENSG00000125733.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3565, Eukaryota
GeneTreeiENSGT00950000183047
HOGENOMiCLU_023320_1_0_1
InParanoidiQ15642
OMAiQERKTHF
OrthoDBi348563at2759
PhylomeDBiQ15642
TreeFamiTF351162

Enzyme and pathway databases

PathwayCommonsiQ15642
ReactomeiR-HSA-194840, Rho GTPase cycle
R-HSA-8856828, Clathrin-mediated endocytosis
SignaLinkiQ15642
SIGNORiQ15642

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9322, 4 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIP10, human
EvolutionaryTraceiQ15642

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRIP10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9322
PharosiQ15642, Tbio

Protein Ontology

More...PROi		PR:Q15642
RNActiQ15642, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125733, Expressed in lower esophagus mucosa and 218 other tissues
ExpressionAtlasiQ15642, baseline and differential
GenevisibleiQ15642, HS

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR028498, CIP4
IPR031160, F_BAR
IPR001060, FCH_dom
IPR011072, HR1_rho-bd
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR15735:SF17, PTHR15735:SF17, 1 hit
PfamiView protein in Pfam
PF00611, FCH, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00055, FCH, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741, F_BAR, 1 hit
PS51860, REM_1, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCIP4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15642
Secondary accession number(s): B2R8A6
, B7WP22, D6W645, O15184, Q53G22, Q5TZN1, Q6FI24, Q8NFL1, Q8TCY1, Q8TDX3, Q96RJ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2006
Last modified: February 10, 2021
This is version 199 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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