SF1

Functionⁱ

Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.

3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	277 – 296	CCHC-typePROSITE-ProRule annotationAdd BLAST		20

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- "Dynamic protein-protein interaction wiring of the human spliceosome."
  Hegele A., Kamburov A., Grossmann A., Sourlis C., Wowro S., Weimann M., Will C.L., Pena V., Luehrmann R., Stelzl U.
  Mol. Cell 45:567-580(2012) [PubMed] [Europe PMC] [Abstract]
- "Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins."
  Crisci A., Raleff F., Bagdiul I., Raabe M., Urlaub H., Rain J.C., Kramer A.
  Nucleic Acids Res 43:10456-10473(2015) [PubMed] [Europe PMC] [Abstract]
mRNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
pre-mRNA branch point binding Source: InterPro
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins."
  Castello A., Fischer B., Eichelbaum K., Horos R., Beckmann B.M., Strein C., Davey N.E., Humphreys D.T., Preiss T., Steinmetz L.M., Krijgsveld J., Hentze M.W.
  Cell 149:1393-1406(2012) [PubMed] [Europe PMC] [Abstract]
- "The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts."
  Baltz A.G., Munschauer M., Schwanhausser B., Vasile A., Murakawa Y., Schueler M., Youngs N., Penfold-Brown D., Drew K., Milek M., Wyler E., Bonneau R., Selbach M., Dieterich C., Landthaler M.
  Mol Cell 46:674-690(2012) [PubMed] [Europe PMC] [Abstract]
transcription corepressor activity
Source: ProtInc
Traceable author statementⁱ
- Ref.11
  "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription."
  Zhang D., Paley A.J., Childs G.
  J. Biol. Chem. 273:18086-18091(1998) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, INTERACTION WITH EWSR1; FUS AND TAF15.
zinc ion binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor, RNA-binding
Biological process	mRNA processing, mRNA splicing, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	Q15637
Reactomeⁱ	R-HSA-72163, mRNA Splicing - Major Pathway
SignaLinkⁱ	Q15637
SIGNORⁱ	Q15637

Protein family/group databases

MoonDBⁱ	Q15637, Predicted

MoonDBⁱ

Q15637, Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Splicing factor 1 Alternative name(s): Mammalian branch point-binding protein Short name: BBP Short name: mBBP Transcription factor ZFM1 Zinc finger gene in MEN1 locus Zinc finger protein 162
Gene namesⁱ	Name:SF1 Synonyms:ZFM1, ZNF162
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12950, SF1
MIMⁱ	601516, gene
neXtProtⁱ	NX_Q15637
VEuPathDBⁱ	HostDB:ENSG00000168066

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	15 – 17	KKR → EED: Abolishes interaction with U2AF2.	3
Mutagenesisⁱ	16 – 18	KRK → EDE: Abolishes interaction with U2AF2. 1 Publication	3
Mutagenesisⁱ	20	S → A: Strongly decreases interaction with U2AF2 and spliceosome assembly. 1 Publication	1
Mutagenesisⁱ	20	S → T: Decreases interaction with U2AF2. 1 Publication	1
Mutagenesisⁱ	21	R → A: Decreases interaction with U2AF2 and spliceosome assembly. 1 Publication	1
Mutagenesisⁱ	21	R → K: No effect. 1 Publication	1
Mutagenesisⁱ	22	W → A: Abolishes interaction with U2AF2. 1 Publication	1
Mutagenesisⁱ	22	W → F: No effect. 1 Publication	1
Mutagenesisⁱ	151	N → A: Decreases RNA-binding. 1 Publication	1
Mutagenesisⁱ	160	R → A: Strongly reduces RNA-binding. 1 Publication	1
Mutagenesisⁱ	184	K → A: Abolishes RNA-binding. 1 Publication	1
Mutagenesisⁱ	244	L → A: Decreases RNA-binding. 1 Publication	1
Mutagenesisⁱ	247	L → A: Decreases RNA-binding. 1 Publication	1
Mutagenesisⁱ	254	L → A: Slightly decreases RNA-binding. 1 Publication	1
Mutagenesisⁱ	255	R → A: Slightly decreases RNA-binding. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7536
Open Targets More...OpenTargetsⁱ	ENSG00000168066
PharmGKBⁱ	PA37533

Miscellaneous databases

Pharosⁱ	Q15637, Tbio

Pharosⁱ

Q15637, Tbio

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB11638, Artenimol

DrugBankⁱ

DB11638, Artenimol

Genetic variation databases

BioMutaⁱ	SF1
DMDMⁱ	38258418

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000050129	2 – 639	Splicing factor 1Add BLAST		638

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	14	PhosphoserineCombined sources	1
Modified residueⁱ	20	Phosphoserine; by PKG1 Publication	1
Modified residueⁱ	80	PhosphoserineCombined sources	1
Modified residueⁱ	82	PhosphoserineCombined sources	1
Modified residueⁱ	87	PhosphotyrosineCombined sources	1
Modified residueⁱ	89	PhosphoserineCombined sources	1
Isoform 6 (identifier: Q15637-6)
Modified residueⁱ	463	PhosphoserineCombined sources	1
Modified residueⁱ	467	Omega-N-methylarginineCombined sources	1

Post-translational modificationⁱ

Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463.1 Publication

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q15637
jPOSTⁱ	Q15637
MassIVEⁱ	Q15637
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15637
PaxDbⁱ	Q15637
PeptideAtlas More...PeptideAtlasⁱ	Q15637
PRIDEⁱ	Q15637
ProteomicsDBⁱ	10457 60669 [Q15637-1] 60670 [Q15637-2] 60671 [Q15637-3] 60672 [Q15637-4] 60673 [Q15637-5] 60674 [Q15637-6]
TopDownProteomicsⁱ	Q15637-4 [Q15637-4]

PTM databases

GlyGenⁱ	Q15637, 9 sites, 2 O-linked glycans (9 sites)
iPTMnetⁱ	Q15637
MetOSiteⁱ	Q15637
PhosphoSitePlusⁱ	Q15637
SwissPalmⁱ	Q15637

Expressionⁱ

Tissue specificityⁱ

Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000168066, Expressed in testis and 253 other tissues
ExpressionAtlasⁱ	Q15637, baseline and differential
Genevisibleⁱ	Q15637, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000168066, Low tissue specificity

HPAⁱ

ENSG00000168066, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Binds U2AF2.

Interacts with U1 snRNA. Binds EWSR1, FUS and TAF15.

Interacts with RBM17.

7 Publications

Binary interactionsⁱ

Hide details

Q15637

With	#Exp.	IntAct
ABL2 [P42684]	3	EBI-744603,EBI-1102694
CEP104 [O60308]	4	EBI-744603,EBI-2685240
CHERP [Q8IWX8]	6	EBI-744603,EBI-2555370
CIAO1 [O76071]	3	EBI-744603,EBI-725145
DDX17 [Q92841]	4	EBI-744603,EBI-746012
DDX5 [P17844]	3	EBI-744603,EBI-351962
FAM168A [Q92567]	4	EBI-744603,EBI-7957930
HNRNPAB [Q99729]	4	EBI-744603,EBI-1044873
HNRNPDL [O14979]	4	EBI-744603,EBI-299727
KHDC4 [Q7Z7F0]	5	EBI-744603,EBI-751942
KPNA1 [P52294]	3	EBI-744603,EBI-358383
KPNA2 [P52292]	5	EBI-744603,EBI-349938
KPNA6 [O60684]	4	EBI-744603,EBI-359923
KRTAP26-1 [Q6PEX3]	3	EBI-744603,EBI-3957672
MKRN3 [Q13064]	3	EBI-744603,EBI-2340269
PRMT2 [P55345]	5	EBI-744603,EBI-78458
PRPF40A [O75400]	3	EBI-744603,EBI-473291
PSMA3 [P25788]	3	EBI-744603,EBI-348380
RBM17 [Q96I25]	8	EBI-744603,EBI-740272
itself	3	EBI-744603,EBI-744603
SF3A1 [Q15459]	8	EBI-744603,EBI-1054743
SF3A2 [Q15428]	2	EBI-744603,EBI-2462271
SFSWAP [Q12872]	2	EBI-744603,EBI-1055938
TRIM69 [Q86WT6]	3	EBI-744603,EBI-749955
U2AF2 [P26368]	22	EBI-744603,EBI-742339
UHMK1 [Q8TAS1]	4	EBI-744603,EBI-1753608
Cep104 [Q80V31] from Mus musculus.	3	EBI-744603,EBI-11073001
Cherp [Q8CGZ0] from Mus musculus.	3	EBI-744603,EBI-2366446
Cltc [Q68FD5] from Mus musculus.	3	EBI-744603,EBI-769168
Khdc4 [Q3TCX3] from Mus musculus.	3	EBI-744603,EBI-11298408
Kpna1 [Q60960] from Mus musculus.	3	EBI-744603,EBI-8573008
Kpna2 [P52293] from Mus musculus.	3	EBI-744603,EBI-3043908
Kpna4 [O35343] from Mus musculus.	3	EBI-744603,EBI-8372758
Sfswap [Q3USH5] from Mus musculus.	3	EBI-744603,EBI-8387273
U2af2 [P26369] from Mus musculus.	3	EBI-744603,EBI-8321355

Isoform 4 [Q15637-4]

With	#Exp.	IntAct
ATXN1 [P54253]	3	EBI-12223157,EBI-930964
NCK2 [O43639]	3	EBI-12223157,EBI-713635
PUF60 - isoform 2 [Q9UHX1-2]	3	EBI-12223157,EBI-11529177
RBM17 [Q96I25]	3	EBI-12223157,EBI-740272
SEC23A [Q15436]	3	EBI-12223157,EBI-81088
TNPO2 - isoform 2 [O14787-2]	3	EBI-12223157,EBI-12076664
TXNL4B [Q9NX01]	3	EBI-12223157,EBI-10309345
U2AF2 - isoform 2 [P26368-2]	5	EBI-12223157,EBI-11097439
UBL5 [Q9BZL1]	3	EBI-12223157,EBI-607755

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	113368, 270 interactors
ComplexPortalⁱ	CPX-1074, SF1-U2AF65 splicing factor complex
CORUMⁱ	Q15637
Database of interacting proteins More...DIPⁱ	DIP-29410N
ELMⁱ	Q15637
IntActⁱ	Q15637, 228 interactors
Molecular INTeraction database More...MINTⁱ	Q15637
STRINGⁱ	9606.ENSP00000366604

Miscellaneous databases

RNActⁱ	Q15637, protein

RNActⁱ

Q15637, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	15 – 17	Combined sources	3
Helixⁱ	27 – 30	Combined sources	4
Helixⁱ	46 – 67	Combined sources	22
Helixⁱ	76 – 79	Combined sources	4
Beta strandⁱ	93 – 95	Combined sources	3
Helixⁱ	97 – 115	Combined sources	19
Helixⁱ	116 – 118	Combined sources	3
Beta strandⁱ	136 – 141	Combined sources	6
Turnⁱ	144 – 146	Combined sources	3
Helixⁱ	150 – 157	Combined sources	8
Beta strandⁱ	159 – 161	Combined sources	3
Helixⁱ	162 – 170	Combined sources	9
Beta strandⁱ	174 – 190	Combined sources	17
Beta strandⁱ	203 – 211	Combined sources	9
Helixⁱ	212 – 226	Combined sources	15
Turnⁱ	227 – 230	Combined sources	4
Helixⁱ	238 – 244	Combined sources	7
Helixⁱ	245 – 248	Combined sources	4
Turnⁱ	249 – 252	Combined sources	4

Show more details

3D structure databases

AlphaFoldDBⁱ	Q15637
BMRBⁱ	Q15637
SMRⁱ	Q15637
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q15637

EvolutionaryTraceⁱ

Q15637

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	141 – 222	KHPROSITE-ProRule annotationAdd BLAST		82

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 42	DisorderedSequence analysisAdd BLAST	42
Regionⁱ	65 – 94	DisorderedSequence analysisAdd BLAST	30
Regionⁱ	325 – 639	DisorderedSequence analysisAdd BLAST	315

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	15 – 19	Nuclear localization signalSequence analysis		5

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	346 – 361	Pro residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	415 – 445	Pro residuesSequence analysisAdd BLAST	31
Compositional biasⁱ	472 – 518	Pro residuesSequence analysisAdd BLAST	47
Compositional biasⁱ	519 – 561	Polar residuesSequence analysisAdd BLAST	43
Compositional biasⁱ	564 – 610	Pro residuesSequence analysisAdd BLAST	47
Compositional biasⁱ	625 – 639	Pro residuesSequence analysisAdd BLAST	15

Sequence similaritiesⁱ

Belongs to the BBP/SF1 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	277 – 296	CCHC-typePROSITE-ProRule annotationAdd BLAST		20

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0119, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157258
HOGENOMⁱ	CLU_016864_5_0_1
InParanoidⁱ	Q15637
OMAⁱ	GAAPWHQ
Database of Orthologous Groups More...OrthoDBⁱ	887669at2759
PhylomeDBⁱ	Q15637
TreeFamⁱ	TF319159

Family and domain databases

Database of protein disorder More...DisProtⁱ	DP01449
Gene3Dⁱ	3.30.1370.10, 1 hit
IDEALⁱ	IID00247
InterProⁱ	View protein in InterPro IPR045071, BBP-like IPR031150, BBP/SF1 IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR032570, SF1-HH IPR001878, Znf_CCHC
PANTHERⁱ	PTHR11208, PTHR11208, 1 hit PTHR11208:SF45, PTHR11208:SF45, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013, KH_1, 1 hit PF16275, SF1-HH, 1 hit PF00098, zf-CCHC, 1 hit
SMARTⁱ	View protein in SMART SM00322, KH, 1 hit SM00343, ZnF_C2HC, 1 hit
SUPFAMⁱ	SSF54791, SSF54791, 1 hit
PROSITEⁱ	View protein in PROSITE PS50084, KH_TYPE_1, 1 hit PS50158, ZF_CCHC, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15637-1) [UniParc]FASTA Add to basket

Also known as: SF1-HL1

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATGANATPL DFPSKKRKRS RWNQDTMEQK TVIPGMPTVI PPGLTREQER 
        60         70         80         90        100
AYIVQLQIED LTRKLRTGDL GIPPNPEDRS PSPEPIYNSE GKRLNTREFR 
       110        120        130        140        150
TRKKLEEERH NLITEMVALN PDFKPPADYK PPATRVSDKV MIPQDEYPEI 
       160        170        180        190        200
NFVGLLIGPR GNTLKNIEKE CNAKIMIRGK GSVKEGKVGR KDGQMLPGED 
       210        220        230        240        250
EPLHALVTAN TMENVKKAVE QIRNILKQGI ETPEDQNDLR KMQLRELARL 
       260        270        280        290        300
NGTLREDDNR ILRPWQSSET RSITNTTVCT KCGGAGHIAS DCKFQRPGDP 
       310        320        330        340        350
QSAQDKARMD KEYLSLMAEL GEAPVPASVG STSGPATTPL ASAPRPAAPA 
       360        370        380        390        400
NNPPPPSLMS TTQSRPPWMN SGPSESRPYH GMHGGGPGGP GGGPHSFPHP 
       410        420        430        440        450
LPSLTGGHGG HPMQHNPNGP PPPWMQPPPP PMNQGPHPPG HHGPPPMDQY 
       460        470        480        490        500
LGSTPVGSGV YRLHQGKGMM PPPPMGMMPP PPPPPSGQPP PPPSGPLPPW 
       510        520        530        540        550
QQQQQQPPPP PPPSSSMASS TPLPWQQNTT TTTTSAGTGS IPPWQQQQAA 
       560        570        580        590        600
AAASPGAPQM QGNPTMVPLP PGVQPPLPPG APPPPPPPPP GSAGMMYAPP 
       610        620        630 
PPPPPPMDPS NFVTMMGMGV AGMPPFGMPP APPPPPPQN

Length:639

Mass (Da):68,330

Last modified:January 23, 2007 - v4

Checksum:ⁱEEBC6A02B29DAE4D

GO

Isoform 2 (identifier: Q15637-2) [UniParc]FASTA Add to basket

Also known as: SF1-Bo, Bone

The sequence of this isoform differs from the canonical sequence as follows:
597-639: YAPPPPPPPP...PAPPPPPPQN → IPPRGGDGPS...WWTGWFGKAA

« Hide

        10         20         30         40         50
MATGANATPL DFPSKKRKRS RWNQDTMEQK TVIPGMPTVI PPGLTREQER 
        60         70         80         90        100
AYIVQLQIED LTRKLRTGDL GIPPNPEDRS PSPEPIYNSE GKRLNTREFR 
       110        120        130        140        150
TRKKLEEERH NLITEMVALN PDFKPPADYK PPATRVSDKV MIPQDEYPEI 
       160        170        180        190        200
NFVGLLIGPR GNTLKNIEKE CNAKIMIRGK GSVKEGKVGR KDGQMLPGED 
       210        220        230        240        250
EPLHALVTAN TMENVKKAVE QIRNILKQGI ETPEDQNDLR KMQLRELARL 
       260        270        280        290        300
NGTLREDDNR ILRPWQSSET RSITNTTVCT KCGGAGHIAS DCKFQRPGDP 
       310        320        330        340        350
QSAQDKARMD KEYLSLMAEL GEAPVPASVG STSGPATTPL ASAPRPAAPA 
       360        370        380        390        400
NNPPPPSLMS TTQSRPPWMN SGPSESRPYH GMHGGGPGGP GGGPHSFPHP 
       410        420        430        440        450
LPSLTGGHGG HPMQHNPNGP PPPWMQPPPP PMNQGPHPPG HHGPPPMDQY 
       460        470        480        490        500
LGSTPVGSGV YRLHQGKGMM PPPPMGMMPP PPPPPSGQPP PPPSGPLPPW 
       510        520        530        540        550
QQQQQQPPPP PPPSSSMASS TPLPWQQNTT TTTTSAGTGS IPPWQQQQAA 
       560        570        580        590        600
AAASPGAPQM QGNPTMVPLP PGVQPPLPPG APPPPPPPPP GSAGMMIPPR 
       610        620        630 
GGDGPSHESE DFPRPLVTLP GRQPQQRPWW TGWFGKAA

Show »

Length:638

Mass (Da):68,633

Checksum:ⁱ06044F670EDC10C9

GO

Isoform 3 (identifier: Q15637-3) [UniParc]FASTA Add to basket

Also known as: ZFM1-A, ZFM1-ABCDEF

The sequence of this isoform differs from the canonical sequence as follows:
587-639: PPPPGSAGMM...PAPPPPPPQN → RSIECLLCLL...PSPRRRWPEP

« Hide

        10         20         30         40         50
MATGANATPL DFPSKKRKRS RWNQDTMEQK TVIPGMPTVI PPGLTREQER 
        60         70         80         90        100
AYIVQLQIED LTRKLRTGDL GIPPNPEDRS PSPEPIYNSE GKRLNTREFR 
       110        120        130        140        150
TRKKLEEERH NLITEMVALN PDFKPPADYK PPATRVSDKV MIPQDEYPEI 
       160        170        180        190        200
NFVGLLIGPR GNTLKNIEKE CNAKIMIRGK GSVKEGKVGR KDGQMLPGED 
       210        220        230        240        250
EPLHALVTAN TMENVKKAVE QIRNILKQGI ETPEDQNDLR KMQLRELARL 
       260        270        280        290        300
NGTLREDDNR ILRPWQSSET RSITNTTVCT KCGGAGHIAS DCKFQRPGDP 
       310        320        330        340        350
QSAQDKARMD KEYLSLMAEL GEAPVPASVG STSGPATTPL ASAPRPAAPA 
       360        370        380        390        400
NNPPPPSLMS TTQSRPPWMN SGPSESRPYH GMHGGGPGGP GGGPHSFPHP 
       410        420        430        440        450
LPSLTGGHGG HPMQHNPNGP PPPWMQPPPP PMNQGPHPPG HHGPPPMDQY 
       460        470        480        490        500
LGSTPVGSGV YRLHQGKGMM PPPPMGMMPP PPPPPSGQPP PPPSGPLPPW 
       510        520        530        540        550
QQQQQQPPPP PPPSSSMASS TPLPWQQNTT TTTTSAGTGS IPPWQQQQAA 
       560        570        580        590        600
AAASPGAPQM QGNPTMVPLP PGVQPPLPPG APPPPPRSIE CLLCLLSLLT 
       610        620 
QLPLPLPKPG RQDPSPRRRW PEP

Show »

Length:623

Mass (Da):67,277

Checksum:ⁱC07C74BBDC4093B7

GO

Isoform 4 (identifier: Q15637-4) [UniParc]FASTA Add to basket

Also known as: ZFM1-B, ZFM1-ABCDF

The sequence of this isoform differs from the canonical sequence as follows:
528-548: NTTTTTTSAGTGSIPPWQQQQ → RSLPAAAMARAMRVRTFRAHW
549-639: Missing.

« Hide

        10         20         30         40         50
MATGANATPL DFPSKKRKRS RWNQDTMEQK TVIPGMPTVI PPGLTREQER 
        60         70         80         90        100
AYIVQLQIED LTRKLRTGDL GIPPNPEDRS PSPEPIYNSE GKRLNTREFR 
       110        120        130        140        150
TRKKLEEERH NLITEMVALN PDFKPPADYK PPATRVSDKV MIPQDEYPEI 
       160        170        180        190        200
NFVGLLIGPR GNTLKNIEKE CNAKIMIRGK GSVKEGKVGR KDGQMLPGED 
       210        220        230        240        250
EPLHALVTAN TMENVKKAVE QIRNILKQGI ETPEDQNDLR KMQLRELARL 
       260        270        280        290        300
NGTLREDDNR ILRPWQSSET RSITNTTVCT KCGGAGHIAS DCKFQRPGDP 
       310        320        330        340        350
QSAQDKARMD KEYLSLMAEL GEAPVPASVG STSGPATTPL ASAPRPAAPA 
       360        370        380        390        400
NNPPPPSLMS TTQSRPPWMN SGPSESRPYH GMHGGGPGGP GGGPHSFPHP 
       410        420        430        440        450
LPSLTGGHGG HPMQHNPNGP PPPWMQPPPP PMNQGPHPPG HHGPPPMDQY 
       460        470        480        490        500
LGSTPVGSGV YRLHQGKGMM PPPPMGMMPP PPPPPSGQPP PPPSGPLPPW 
       510        520        530        540 
QQQQQQPPPP PPPSSSMASS TPLPWQQRSL PAAAMARAMR VRTFRAHW

Show »

Length:548

Mass (Da):59,712

Checksum:ⁱDDB42B66ABA2AD18

GO

Isoform 5 (identifier: Q15637-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: L → LGKLGPPGLP...QQPGPAGGGG
     528-548: NTTTTTTSAGTGSIPPWQQQQ → RSLPAAAMARAMRVRTFRAHW
     549-639: Missing.

« Hide

        10         20         30         40         50
MATGANATPL GKLGPPGLPP LPGPKGGFEP GPPPAPGPGA GLLAPGPPPP 
        60         70         80         90        100
PPVGSMGALT AAFPFAALPP PPPPPPPPPP QQPPPPPPPP SPGASYPPPQ 
       110        120        130        140        150
PPPPPPLYQR VSPPQPPPPQ PPRKDQQPGP AGGGGDFPSK KRKRSRWNQD 
       160        170        180        190        200
TMEQKTVIPG MPTVIPPGLT REQERAYIVQ LQIEDLTRKL RTGDLGIPPN 
       210        220        230        240        250
PEDRSPSPEP IYNSEGKRLN TREFRTRKKL EEERHNLITE MVALNPDFKP 
       260        270        280        290        300
PADYKPPATR VSDKVMIPQD EYPEINFVGL LIGPRGNTLK NIEKECNAKI 
       310        320        330        340        350
MIRGKGSVKE GKVGRKDGQM LPGEDEPLHA LVTANTMENV KKAVEQIRNI 
       360        370        380        390        400
LKQGIETPED QNDLRKMQLR ELARLNGTLR EDDNRILRPW QSSETRSITN 
       410        420        430        440        450
TTVCTKCGGA GHIASDCKFQ RPGDPQSAQD KARMDKEYLS LMAELGEAPV 
       460        470        480        490        500
PASVGSTSGP ATTPLASAPR PAAPANNPPP PSLMSTTQSR PPWMNSGPSE 
       510        520        530        540        550
SRPYHGMHGG GPGGPGGGPH SFPHPLPSLT GGHGGHPMQH NPNGPPPPWM 
       560        570        580        590        600
QPPPPPMNQG PHPPGHHGPP PMDQYLGSTP VGSGVYRLHQ GKGMMPPPPM 
       610        620        630        640        650
GMMPPPPPPP SGQPPPPPSG PLPPWQQQQQ QPPPPPPPSS SMASSTPLPW 
       660        670 
QQRSLPAAAM ARAMRVRTFR AHW

Show »

Length:673

Mass (Da):71,752

Checksum:ⁱ8F39B77A4DAE9FBD

GO

Isoform 6 (identifier: Q15637-6) [UniParc]FASTA Add to basket

Also known as: ZFM1-D, B6

The sequence of this isoform differs from the canonical sequence as follows:
448-548: DQYLGSTPVG...GSIPPWQQQQ → GKSVPGKYACGLWGLSPASRKRYDAATTYGHDA
555-639: PGAPQMQGNP...PAPPPPPPQN → QWAAPTPSLW...WWTGWFGKAA

« Hide

        10         20         30         40         50
MATGANATPL DFPSKKRKRS RWNQDTMEQK TVIPGMPTVI PPGLTREQER 
        60         70         80         90        100
AYIVQLQIED LTRKLRTGDL GIPPNPEDRS PSPEPIYNSE GKRLNTREFR 
       110        120        130        140        150
TRKKLEEERH NLITEMVALN PDFKPPADYK PPATRVSDKV MIPQDEYPEI 
       160        170        180        190        200
NFVGLLIGPR GNTLKNIEKE CNAKIMIRGK GSVKEGKVGR KDGQMLPGED 
       210        220        230        240        250
EPLHALVTAN TMENVKKAVE QIRNILKQGI ETPEDQNDLR KMQLRELARL 
       260        270        280        290        300
NGTLREDDNR ILRPWQSSET RSITNTTVCT KCGGAGHIAS DCKFQRPGDP 
       310        320        330        340        350
QSAQDKARMD KEYLSLMAEL GEAPVPASVG STSGPATTPL ASAPRPAAPA 
       360        370        380        390        400
NNPPPPSLMS TTQSRPPWMN SGPSESRPYH GMHGGGPGGP GGGPHSFPHP 
       410        420        430        440        450
LPSLTGGHGG HPMQHNPNGP PPPWMQPPPP PMNQGPHPPG HHGPPPMGKS 
       460        470        480        490        500
VPGKYACGLW GLSPASRKRY DAATTYGHDA AAAAASQWAA PTPSLWSSSP 
       510        520        530        540        550
MATTAAAASA TPSAQQQYGF QYPLAMAAKI PPRGGDGPSH ESEDFPRPLV 
       560        570 
TLPGRQPQQR PWWTGWFGKA A

Show »

Length:571

Mass (Da):61,889

Checksum:ⁱ5DA04D16D93EBDD5

GO

Isoform 7 (identifier: Q15637-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-26: Missing.

« Hide

        10         20         30         40         50
MEQKTVIPGM PTVIPPGLTR EQERAYIVQL QIEDLTRKLR TGDLGIPPNP 
        60         70         80         90        100
EDRSPSPEPI YNSEGKRLNT REFRTRKKLE EERHNLITEM VALNPDFKPP 
       110        120        130        140        150
ADYKPPATRV SDKVMIPQDE YPEINFVGLL IGPRGNTLKN IEKECNAKIM 
       160        170        180        190        200
IRGKGSVKEG KVGRKDGQML PGEDEPLHAL VTANTMENVK KAVEQIRNIL 
       210        220        230        240        250
KQGIETPEDQ NDLRKMQLRE LARLNGTLRE DDNRILRPWQ SSETRSITNT 
       260        270        280        290        300
TVCTKCGGAG HIASDCKFQR PGDPQSAQDK ARMDKEYLSL MAELGEAPVP 
       310        320        330        340        350
ASVGSTSGPA TTPLASAPRP AAPANNPPPP SLMSTTQSRP PWMNSGPSES 
       360        370        380        390        400
RPYHGMHGGG PGGPGGGPHS FPHPLPSLTG GHGGHPMQHN PNGPPPPWMQ 
       410        420        430        440        450
PPPPPMNQGP HPPGHHGPPP MDQYLGSTPV GSGVYRLHQG KGMMPPPPMG 
       460        470        480        490        500
MMPPPPPPPS GQPPPPPSGP LPPWQQQQQQ PPPPPPPSSS MASSTPLPWQ 
       510        520        530        540        550
QNTTTTTTSA GTGSIPPWQQ QQAAAAASPG APQMQGNPTM VPLPPGVQPP 
       560        570        580        590        600
LPPGAPPPPP PPPPGSAGMM YAPPPPPPPP MDPSNFVTMM GMGVAGMPPF 
       610 
GMPPAPPPPP PQN

Show »

Length:613

Mass (Da):65,371

Checksum:ⁱC1EBBE4FC3AA66BF

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7C561	H7C561_HUMAN	Splicing factor 1 Splicing factor 1	SF1	291	Annotation score:
A0A7P0T9U7	A0A7P0T9U7_HUMAN	Splicing factor 1 Splicing factor 1	SF1	764	Annotation score:
C9J792	C9J792_HUMAN	Splicing factor 1 Splicing factor 1	SF1	62	Annotation score:
H7C0N4	H7C0N4_HUMAN	Splicing factor 1 Splicing factor 1	SF1	180	Annotation score:
F8WEV5	F8WEV5_HUMAN	Splicing factor 1 Splicing factor 1	SF1	110	Annotation score:
H7BZT1	H7BZT1_HUMAN	Splicing factor 1 Splicing factor 1	SF1	200	Annotation score:
F8WEG7	F8WEG7_HUMAN	Splicing factor 1 Splicing factor 1	SF1	51	Annotation score:

Sequence cautionⁱ

The sequence AAH00773 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	269	E → G in BAA05116 (PubMed:7912130).Curated	1
Sequence conflictⁱ	269	E → G in BAA05117 (PubMed:7912130).Curated	1
Sequence conflictⁱ	348	A → R in AAB03514 (PubMed:9192847).Curated	1
Sequence conflictⁱ	348	A → R in AAB04033 (PubMed:9192847).Curated	1
Sequence conflictⁱ	377	R → W in BAA05116 (PubMed:7912130).Curated	1
Sequence conflictⁱ	377	R → W in BAA05117 (PubMed:7912130).Curated	1
Sequence conflictⁱ	570	P → L in BAH11587 (PubMed:14702039).Curated	1
Sequence conflictⁱ	591	G → V in AAB04033 (PubMed:9192847).Curated	1
Sequence conflictⁱ	623	M → I in AAB04033 (PubMed:9192847).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_017196	357	S → T1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045274	1 – 26	Missing in isoform 7. 1 PublicationAdd BLAST	26
Alternative sequenceⁱVSP_008833	10	L → LGKLGPPGLPPLPGPKGGFE PGPPPAPGPGAGLLAPGPPP PPPVGSMGALTAAFPFAALP PPPPPPPPPPPQQPPPPPPP PSPGASYPPPQPPPPPPLYQ RVSPPQPPPPQPPRKDQQPG PAGGGG in isoform 5. 1 Publication	1
Alternative sequenceⁱVSP_008834	448 – 548	DQYLG…WQQQQ → GKSVPGKYACGLWGLSPASR KRYDAATTYGHDA in isoform 6. 1 PublicationAdd BLAST	101
Alternative sequenceⁱVSP_008835	528 – 548	NTTTT…WQQQQ → RSLPAAAMARAMRVRTFRAH W in isoform 4 and isoform 5. 2 PublicationsAdd BLAST	21
Alternative sequenceⁱVSP_008836	549 – 639	Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST	91
Alternative sequenceⁱVSP_008837	555 – 639	PGAPQ…PPPQN → QWAAPTPSLWSSSPMATTAA AASATPSAQQQYGFQYPLAM AAKIPPRGGDGPSHESEDFP RPLVTLPGRQPQQRPWWTGW FGKAA in isoform 6. 1 PublicationAdd BLAST	85
Alternative sequenceⁱVSP_008838	587 – 639	PPPPG…PPPQN → RSIECLLCLLSLLTQLPLPL PKPGRQDPSPRRRWPEP in isoform 3. 1 PublicationAdd BLAST	53
Alternative sequenceⁱVSP_008839	597 – 639	YAPPP…PPPQN → IPPRGGDGPSHESEDFPRPL VTLPGRQPQQRPWWTGWFGK AA in isoform 2. 1 PublicationAdd BLAST	43

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08765 mRNA Translation: CAA70018.1 Y08766 mRNA Translation: CAA70019.1 L49345 mRNA Translation: AAB03514.1 L49380 mRNA Translation: AAB04033.1 D26120 mRNA Translation: BAA05116.1 D26120 mRNA Translation: BAA05117.1 AK293753 mRNA Translation: BAH11587.1 AP001462 Genomic DNA No translation available. BC000773 mRNA Translation: AAH00773.1 Different initiation. BC008080 mRNA Translation: AAH08080.1 BC008724 mRNA Translation: AAH08724.1 BC011657 mRNA No translation available. BC020217 mRNA Translation: AAH20217.1 BC038446 mRNA Translation: AAH38446.1 AJ000051, AJ000052 Genomic DNA Translation: CAA03883.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31599.1 [Q15637-1] CCDS44642.2 [Q15637-6] CCDS53660.1 [Q15637-7] CCDS53661.1 [Q15637-5] CCDS8080.1 [Q15637-2] CCDS8081.1 [Q15637-4]
PIRⁱ	G02919
NCBI Reference Sequences More...RefSeqⁱ	NP_001171501.1, NM_001178030.1 [Q15637-5] NP_001171502.1, NM_001178031.2 [Q15637-7] NP_001333292.1, NM_001346363.1 NP_001333293.1, NM_001346364.1 NP_004621.2, NM_004630.3 [Q15637-1] NP_973724.1, NM_201995.2 [Q15637-2] NP_973727.1, NM_201998.2 [Q15637-4] XP_016873733.1, XM_017018244.1

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15637	Splicing factor 1		HUMAN		639	UniRef100_Q15637
Splicing factor 1		BOBOX		639
Splicing factor 1		CALJA		639
Splicing factor 1		MACMU		639
Splicing factor 1		PANTR		639
+33
Q15637-2	Splicing factor 1		HUMAN		638	UniRef100_A0A024R5D9
Splicing factor 1		BOBOX		638
Splicing factor 1		PAPAN		638
Splicing factor 1		CALJA		638
Splicing factor 1		CANLF		638
+24
Q15637-4	Splicing factor 1		HUMAN		548	UniRef100_A0A024R588
Uncharacterized protein		SHEEP		1391
Splicing factor 1		RHIRO		522
Splicing factor 1		MICMU		522
Splicing factor 1		PANPR		522
+39
Q15637-6	Splicing factor 1		HUMAN		571	UniRef100_A0A024R566
Splicing factor 1		PANTR		571
Q15637-7	Splicing factor 1		ICTTR		628	UniRef100_I3ME85
Splicing factor 1 (Fragment)		MUNMU		628
Splicing factor 1		MARMA		628
Splicing factor 1		BOBOX		613
Splicing factor 1		Odocoileus virginianus texanus		613
+16

Protein	Similar proteins		Species	Score	Length	Source
Q15637	Splicing factor 1		HUMAN		639	UniRef90_Q15637
Splicing factor 1		BOBOX		639
Splicing factor 1		CALJA		639
Splicing factor 1		MACMU		639
Splicing factor 1		PANTR		639
+50
Q15637-2	Splicing factor 1		MESAU		638	UniRef90_A0A1U7Q2U0
Splicing factor 1		ZALCA		760
Splicing factor 1		pale spear-nosed bat		760
Splicing factor 1		MANLE		659
Splicing factor 1		NEOVI		638
+119
Q15637-3	Splicing factor 1		LOXAF		645	UniRef90_Q15637-3
Q15637-4	Splicing factor 1		HUMAN		548	UniRef90_A0A024R588
Uncharacterized protein		SHEEP		1391
Splicing factor 1		RHIRO		522
Splicing factor 1		MICMU		522
Splicing factor 1		PANPR		522
+39
Q15637-5	Splicing factor 1		PANTR		675	UniRef90_Q15637-5
Splicing factor 1		CALJA		673
Splicing factor 1		SAPAP		673
Splicing factor 1		CEBIM		673
Splicing factor 1		Ugandan red Colobus		656
+5
Q15637-6	Splicing factor 1		HUMAN		571	UniRef90_A0A024R566
Splicing factor 1		PANTR		571
Splicing factor 1		ROUAE		592
Splicing factor 1		SAPAP		571
Splicing factor 1		TURTR		571
+81
Q15637-7	Splicing factor 1		FELCA		670	UniRef90_A0A2I2U8V5
Splicing factor 1		HUMAN		764
Splicing factor 1		ZALCA		761
Splicing factor 1		ODORO		689
Splicing factor 1		SHEEP		674
+66

Protein	Similar proteins		Species	Score	Length	Source
Q15637	Splicing factor 1		MOUSE		653	UniRef50_Q15637
Splicing factor 1		HUMAN		639
Splicing factor 1		BOBOX		639
Splicing factor 1		CALJA		639
Splicing factor 1		MACMU		639
+581
Q15637-4	Splicing factor 1		HUMAN		548	UniRef50_A0A024R588
Uncharacterized protein		SHEEP		1391
Splicing factor 1		RHIRO		522
Splicing factor 1		MICMU		522
Splicing factor 1		PANPR		522
+43
Q15637-5	Splicing factor 1		PANTR		675	UniRef50_Q15637-5
Splicing factor 1		SAPAP		673
Splicing factor 1		CALJA		673
Splicing factor 1		CEBIM		673
Splicing factor 1		Ugandan red Colobus		656
+792

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08765 mRNA Translation: CAA70018.1 Y08766 mRNA Translation: CAA70019.1 L49345 mRNA Translation: AAB03514.1 L49380 mRNA Translation: AAB04033.1 D26120 mRNA Translation: BAA05116.1 D26120 mRNA Translation: BAA05117.1 AK293753 mRNA Translation: BAH11587.1 AP001462 Genomic DNA No translation available. BC000773 mRNA Translation: AAH00773.1 Different initiation. BC008080 mRNA Translation: AAH08080.1 BC008724 mRNA Translation: AAH08724.1 BC011657 mRNA No translation available. BC020217 mRNA Translation: AAH20217.1 BC038446 mRNA Translation: AAH38446.1 AJ000051, AJ000052 Genomic DNA Translation: CAA03883.1
CCDSⁱ	CCDS31599.1 [Q15637-1] CCDS44642.2 [Q15637-6] CCDS53660.1 [Q15637-7] CCDS53661.1 [Q15637-5] CCDS8080.1 [Q15637-2] CCDS8081.1 [Q15637-4]
PIRⁱ	G02919
RefSeqⁱ	NP_001171501.1, NM_001178030.1 [Q15637-5] NP_001171502.1, NM_001178031.2 [Q15637-7] NP_001333292.1, NM_001346363.1 NP_001333293.1, NM_001346364.1 NP_004621.2, NM_004630.3 [Q15637-1] NP_973724.1, NM_201995.2 [Q15637-2] NP_973727.1, NM_201998.2 [Q15637-4] XP_016873733.1, XM_017018244.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1K1G	NMR	-	A	133-260	[»]
	1O0P	NMR	-	B	13-25	[»]
	1OPI	NMR	-	B	13-25	[»]
	2M09	NMR	-	A	27-145	[»]
	2M0G	NMR	-	A	1-145	[»]
	4FXW	X-ray	2.29	B/D	14-132	[»]
	4FXX	X-ray	2.48	A/B/C/D	26-132	[»]
AlphaFoldDBⁱ	Q15637
BMRBⁱ	Q15637
SMRⁱ	Q15637
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	113368, 270 interactors
ComplexPortalⁱ	CPX-1074, SF1-U2AF65 splicing factor complex
CORUMⁱ	Q15637
DIPⁱ	DIP-29410N
ELMⁱ	Q15637
IntActⁱ	Q15637, 228 interactors
MINTⁱ	Q15637
STRINGⁱ	9606.ENSP00000366604

Chemistry databases

DrugBankⁱ	DB11638, Artenimol

DrugBankⁱ

DB11638, Artenimol

Protein family/group databases

MoonDBⁱ	Q15637, Predicted

MoonDBⁱ

Q15637, Predicted

PTM databases

GlyGenⁱ	Q15637, 9 sites, 2 O-linked glycans (9 sites)
iPTMnetⁱ	Q15637
MetOSiteⁱ	Q15637
PhosphoSitePlusⁱ	Q15637
SwissPalmⁱ	Q15637

Genetic variation databases

BioMutaⁱ	SF1
DMDMⁱ	38258418

Proteomic databases

EPDⁱ	Q15637
jPOSTⁱ	Q15637
MassIVEⁱ	Q15637
MaxQBⁱ	Q15637
PaxDbⁱ	Q15637
PeptideAtlasⁱ	Q15637
PRIDEⁱ	Q15637
ProteomicsDBⁱ	10457 60669 [Q15637-1] 60670 [Q15637-2] 60671 [Q15637-3] 60672 [Q15637-4] 60673 [Q15637-5] 60674 [Q15637-6]
TopDownProteomicsⁱ	Q15637-4 [Q15637-4]

Protocols and materials databases

Antibodypediaⁱ	15586, 417 antibodies from 31 providers
The DNASU plasmid repository More...DNASUⁱ	7536

Genome annotation databases

Ensemblⁱ	ENST00000227503.13; ENSP00000227503.9; ENSG00000168066.21 [Q15637-4] ENST00000334944.9; ENSP00000334414.5; ENSG00000168066.21 [Q15637-2] ENST00000377387.5; ENSP00000366604.1; ENSG00000168066.21 [Q15637-5] ENST00000377390.8; ENSP00000366607.3; ENSG00000168066.21 ENST00000377394.7; ENSP00000366611.3; ENSG00000168066.21 [Q15637-6] ENST00000433274.6; ENSP00000396793.2; ENSG00000168066.21 [Q15637-7]
GeneIDⁱ	7536
KEGGⁱ	hsa:7536
MANE-Selectⁱ	ENST00000377390.8; ENSP00000366607.3; NM_004630.4; NP_004621.2
UCSCⁱ	uc001oaz.3, human [Q15637-1]

Organism-specific databases

CTDⁱ	7536
DisGeNETⁱ	7536
GeneCardsⁱ	SF1
HGNCⁱ	HGNC:12950, SF1
HPAⁱ	ENSG00000168066, Low tissue specificity
MIMⁱ	601516, gene
neXtProtⁱ	NX_Q15637
OpenTargetsⁱ	ENSG00000168066
PharmGKBⁱ	PA37533
VEuPathDBⁱ	HostDB:ENSG00000168066
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0119, Eukaryota
GeneTreeⁱ	ENSGT00940000157258
HOGENOMⁱ	CLU_016864_5_0_1
InParanoidⁱ	Q15637
OMAⁱ	GAAPWHQ
OrthoDBⁱ	887669at2759
PhylomeDBⁱ	Q15637
TreeFamⁱ	TF319159

Enzyme and pathway databases

PathwayCommonsⁱ	Q15637
Reactomeⁱ	R-HSA-72163, mRNA Splicing - Major Pathway
SignaLinkⁱ	Q15637
SIGNORⁱ	Q15637

Miscellaneous databases

BioGRID-ORCSⁱ	7536, 819 hits in 1094 CRISPR screens
ChiTaRSⁱ	SF1, human
EvolutionaryTraceⁱ	Q15637
GeneWikiⁱ	SF1_(gene)
GenomeRNAiⁱ	7536
Pharosⁱ	Q15637, Tbio
Protein Ontology More...PROⁱ	PR:Q15637
RNActⁱ	Q15637, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168066, Expressed in testis and 253 other tissues
ExpressionAtlasⁱ	Q15637, baseline and differential
Genevisibleⁱ	Q15637, HS

Family and domain databases

DisProtⁱ	DP01449
Gene3Dⁱ	3.30.1370.10, 1 hit
IDEALⁱ	IID00247
InterProⁱ	View protein in InterPro IPR045071, BBP-like IPR031150, BBP/SF1 IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR032570, SF1-HH IPR001878, Znf_CCHC
PANTHERⁱ	PTHR11208, PTHR11208, 1 hit PTHR11208:SF45, PTHR11208:SF45, 1 hit
Pfamⁱ	View protein in Pfam PF00013, KH_1, 1 hit PF16275, SF1-HH, 1 hit PF00098, zf-CCHC, 1 hit
SMARTⁱ	View protein in SMART SM00322, KH, 1 hit SM00343, ZnF_C2HC, 1 hit
SUPFAMⁱ	SSF54791, SSF54791, 1 hit
PROSITEⁱ	View protein in PROSITE PS50084, KH_TYPE_1, 1 hit PS50158, ZF_CCHC, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SF01_HUMAN
Accessionⁱ	Q15637Primary (citable) accession number: Q15637 Secondary accession number(s): B7Z1Q1 Q9UEI0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
	Last sequence update:	January 23, 2007
	Last modified:	May 25, 2022
	This is version 217 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - Q15637 (SF01_HUMAN)

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Splicing factor 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q15637

Isoform 4 [Q15637-4]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ