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UniProtKB - Q15637 (SF01_HUMAN)

Protein

Splicing factor 1

Gene

SF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 296CCHC-typePROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • pre-mRNA branch point binding Source: InterPro
  • RNA binding Source: UniProtKB
  • transcription corepressor activity Source: ProtInc
  • zinc ion binding Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
SIGNORiQ15637

Protein family/group databases

MoonDBiQ15637 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor 1
Alternative name(s):
Mammalian branch point-binding protein
Short name:
BBP
Short name:
mBBP
Transcription factor ZFM1
Zinc finger gene in MEN1 locus
Zinc finger protein 162
Gene namesi
Name:SF1
Synonyms:ZFM1, ZNF162
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000168066.20
HGNCiHGNC:12950 SF1
MIMi601516 gene
neXtProtiNX_Q15637

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15 – 17KKR → EED: Abolishes interaction with U2AF2. 3
Mutagenesisi16 – 18KRK → EDE: Abolishes interaction with U2AF2. 1 Publication3
Mutagenesisi20S → A: Strongly decreases interaction with U2AF2 and spliceosome assembly. 1 Publication1
Mutagenesisi20S → T: Decreases interaction with U2AF2. 1 Publication1
Mutagenesisi21R → A: Decreases interaction with U2AF2 and spliceosome assembly. 1 Publication1
Mutagenesisi21R → K: No effect. 1 Publication1
Mutagenesisi22W → A: Abolishes interaction with U2AF2. 1 Publication1
Mutagenesisi22W → F: No effect. 1 Publication1
Mutagenesisi151N → A: Decreases RNA-binding. 1 Publication1
Mutagenesisi160R → A: Strongly reduces RNA-binding. 1 Publication1
Mutagenesisi184K → A: Abolishes RNA-binding. 1 Publication1
Mutagenesisi244L → A: Decreases RNA-binding. 1 Publication1
Mutagenesisi247L → A: Decreases RNA-binding. 1 Publication1
Mutagenesisi254L → A: Slightly decreases RNA-binding. 1 Publication1
Mutagenesisi255R → A: Slightly decreases RNA-binding. 1 Publication1

Organism-specific databases

DisGeNETi7536
OpenTargetsiENSG00000168066
PharmGKBiPA37533

Polymorphism and mutation databases

BioMutaiSF1
DMDMi38258418

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000501292 – 639Splicing factor 1Add BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei14PhosphoserineCombined sources1
Modified residuei20Phosphoserine; by PKG1 Publication1
Modified residuei80PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei87PhosphotyrosineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Isoform 6 (identifier: Q15637-6)
Modified residuei463PhosphoserineCombined sources1
Modified residuei467Omega-N-methylarginineCombined sources1

Post-translational modificationi

Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ15637
MaxQBiQ15637
PaxDbiQ15637
PeptideAtlasiQ15637
PRIDEiQ15637
ProteomicsDBi60669
60670 [Q15637-2]
60671 [Q15637-3]
60672 [Q15637-4]
60673 [Q15637-5]
60674 [Q15637-6]
TopDownProteomicsiQ15637-4 [Q15637-4]

PTM databases

iPTMnetiQ15637
PhosphoSitePlusiQ15637
SwissPalmiQ15637

Expressioni

Tissue specificityi

Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.1 Publication

Gene expression databases

BgeeiENSG00000168066 Expressed in 242 organ(s), highest expression level in testis
CleanExiHS_SF1
ExpressionAtlasiQ15637 baseline and differential
GenevisibleiQ15637 HS

Organism-specific databases

HPAiHPA018883

Interactioni

Subunit structurei

Binds U2AF2. Interacts with U1 snRNA. Binds EWSR1, FUS and TAF15. Interacts with RBM17.7 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi113368, 156 interactors
CORUMiQ15637
DIPiDIP-29410N
ELMiQ15637
IntActiQ15637, 210 interactors
MINTiQ15637
STRINGi9606.ENSP00000366604

Structurei

Secondary structure

1639
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15637
SMRiQ15637
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15637

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 222KHPROSITE-ProRule annotationAdd BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi15 – 19Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi324 – 637Pro-richAdd BLAST314

Sequence similaritiesi

Belongs to the BBP/SF1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 296CCHC-typePROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0119 Eukaryota
COG5176 LUCA
GeneTreeiENSGT00550000074434
HOGENOMiHOG000237321
HOVERGENiHBG063318
InParanoidiQ15637
KOiK13095
OMAiPPLMPWM
OrthoDBiEOG091G0AEL
PhylomeDBiQ15637
TreeFamiTF319159

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR031150 BBP/SF1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR032570 SF1-HH
IPR001878 Znf_CCHC
PANTHERiPTHR11208:SF45 PTHR11208:SF45, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF16275 SF1-HH, 1 hit
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50158 ZF_CCHC, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15637-1) [UniParc]FASTAAdd to basket
Also known as: SF1-HL1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATGANATPL DFPSKKRKRS RWNQDTMEQK TVIPGMPTVI PPGLTREQER 
        60         70         80         90        100
AYIVQLQIED LTRKLRTGDL GIPPNPEDRS PSPEPIYNSE GKRLNTREFR 
       110        120        130        140        150
TRKKLEEERH NLITEMVALN PDFKPPADYK PPATRVSDKV MIPQDEYPEI 
       160        170        180        190        200
NFVGLLIGPR GNTLKNIEKE CNAKIMIRGK GSVKEGKVGR KDGQMLPGED 
       210        220        230        240        250
EPLHALVTAN TMENVKKAVE QIRNILKQGI ETPEDQNDLR KMQLRELARL 
       260        270        280        290        300
NGTLREDDNR ILRPWQSSET RSITNTTVCT KCGGAGHIAS DCKFQRPGDP 
       310        320        330        340        350
QSAQDKARMD KEYLSLMAEL GEAPVPASVG STSGPATTPL ASAPRPAAPA 
       360        370        380        390        400
NNPPPPSLMS TTQSRPPWMN SGPSESRPYH GMHGGGPGGP GGGPHSFPHP 
       410        420        430        440        450
LPSLTGGHGG HPMQHNPNGP PPPWMQPPPP PMNQGPHPPG HHGPPPMDQY 
       460        470        480        490        500
LGSTPVGSGV YRLHQGKGMM PPPPMGMMPP PPPPPSGQPP PPPSGPLPPW 
       510        520        530        540        550
QQQQQQPPPP PPPSSSMASS TPLPWQQNTT TTTTSAGTGS IPPWQQQQAA 
       560        570        580        590        600
AAASPGAPQM QGNPTMVPLP PGVQPPLPPG APPPPPPPPP GSAGMMYAPP 
       610        620        630 
PPPPPPMDPS NFVTMMGMGV AGMPPFGMPP APPPPPPQN
Length:639
Mass (Da):68,330
Last modified:January 23, 2007 - v4
Checksum:iEEBC6A02B29DAE4D
GO
Isoform 2 (identifier: Q15637-2) [UniParc]FASTAAdd to basket
Also known as: SF1-Bo, Bone

The sequence of this isoform differs from the canonical sequence as follows:
     597-639: YAPPPPPPPP...PAPPPPPPQN → IPPRGGDGPS...WWTGWFGKAA

Show »
Length:638
Mass (Da):68,633
Checksum:i06044F670EDC10C9
GO
Isoform 3 (identifier: Q15637-3) [UniParc]FASTAAdd to basket
Also known as: ZFM1-A, ZFM1-ABCDEF

The sequence of this isoform differs from the canonical sequence as follows:
     587-639: PPPPGSAGMM...PAPPPPPPQN → RSIECLLCLL...PSPRRRWPEP

Show »
Length:623
Mass (Da):67,277
Checksum:iC07C74BBDC4093B7
GO
Isoform 4 (identifier: Q15637-4) [UniParc]FASTAAdd to basket
Also known as: ZFM1-B, ZFM1-ABCDF

The sequence of this isoform differs from the canonical sequence as follows:
     528-548: NTTTTTTSAGTGSIPPWQQQQ → RSLPAAAMARAMRVRTFRAHW
     549-639: Missing.

Show »
Length:548
Mass (Da):59,712
Checksum:iDDB42B66ABA2AD18
GO
Isoform 5 (identifier: Q15637-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: L → LGKLGPPGLP...QQPGPAGGGG
     528-548: NTTTTTTSAGTGSIPPWQQQQ → RSLPAAAMARAMRVRTFRAHW
     549-639: Missing.

Note: No experimental confirmation available.
Show »
Length:673
Mass (Da):71,752
Checksum:i8F39B77A4DAE9FBD
GO
Isoform 6 (identifier: Q15637-6) [UniParc]FASTAAdd to basket
Also known as: ZFM1-D, B6

The sequence of this isoform differs from the canonical sequence as follows:
     448-548: DQYLGSTPVG...GSIPPWQQQQ → GKSVPGKYACGLWGLSPASRKRYDAATTYGHDA
     555-639: PGAPQMQGNP...PAPPPPPPQN → QWAAPTPSLW...WWTGWFGKAA

Show »
Length:571
Mass (Da):61,889
Checksum:i5DA04D16D93EBDD5
GO
Isoform 7 (identifier: Q15637-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.

Note: No experimental confirmation available.
Show »
Length:613
Mass (Da):65,371
Checksum:iC1EBBE4FC3AA66BF
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J792C9J792_HUMAN
Splicing factor 1
SF1
62Annotation score:
H7C561H7C561_HUMAN
Splicing factor 1
SF1
291Annotation score:
H7C0N4H7C0N4_HUMAN
Splicing factor 1
SF1
180Annotation score:
H7BZT1H7BZT1_HUMAN
Splicing factor 1
SF1
200Annotation score:
F8WEV5F8WEV5_HUMAN
Splicing factor 1
SF1
110Annotation score:
F8WEG7F8WEG7_HUMAN
Splicing factor 1
SF1
51Annotation score:

Sequence cautioni

The sequence AAH00773 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269E → G in BAA05116 (PubMed:7912130).Curated1
Sequence conflicti269E → G in BAA05117 (PubMed:7912130).Curated1
Sequence conflicti348A → R in AAB03514 (PubMed:9192847).Curated1
Sequence conflicti348A → R in AAB04033 (PubMed:9192847).Curated1
Sequence conflicti377R → W in BAA05116 (PubMed:7912130).Curated1
Sequence conflicti377R → W in BAA05117 (PubMed:7912130).Curated1
Sequence conflicti570P → L in BAH11587 (PubMed:14702039).Curated1
Sequence conflicti591G → V in AAB04033 (PubMed:9192847).Curated1
Sequence conflicti623M → I in AAB04033 (PubMed:9192847).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017196357S → T1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0452741 – 26Missing in isoform 7. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_00883310L → LGKLGPPGLPPLPGPKGGFE PGPPPAPGPGAGLLAPGPPP PPPVGSMGALTAAFPFAALP PPPPPPPPPPPQQPPPPPPP PSPGASYPPPQPPPPPPLYQ RVSPPQPPPPQPPRKDQQPG PAGGGG in isoform 5. 1 Publication1
Alternative sequenceiVSP_008834448 – 548DQYLG…WQQQQ → GKSVPGKYACGLWGLSPASR KRYDAATTYGHDA in isoform 6. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_008835528 – 548NTTTT…WQQQQ → RSLPAAAMARAMRVRTFRAH W in isoform 4 and isoform 5. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_008836549 – 639Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST91
Alternative sequenceiVSP_008837555 – 639PGAPQ…PPPQN → QWAAPTPSLWSSSPMATTAA AASATPSAQQQYGFQYPLAM AAKIPPRGGDGPSHESEDFP RPLVTLPGRQPQQRPWWTGW FGKAA in isoform 6. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_008838587 – 639PPPPG…PPPQN → RSIECLLCLLSLLTQLPLPL PKPGRQDPSPRRRWPEP in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_008839597 – 639YAPPP…PPPQN → IPPRGGDGPSHESEDFPRPL VTLPGRQPQQRPWWTGWFGK AA in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08765 mRNA Translation: CAA70018.1
Y08766 mRNA Translation: CAA70019.1
L49345 mRNA Translation: AAB03514.1
L49380 mRNA Translation: AAB04033.1
D26120 mRNA Translation: BAA05116.1
D26120 mRNA Translation: BAA05117.1
AK293753 mRNA Translation: BAH11587.1
AP001462 Genomic DNA No translation available.
BC000773 mRNA Translation: AAH00773.1 Different initiation.
BC008080 mRNA Translation: AAH08080.1
BC008724 mRNA Translation: AAH08724.1
BC011657 mRNA No translation available.
BC020217 mRNA Translation: AAH20217.1
BC038446 mRNA Translation: AAH38446.1
AJ000051, AJ000052 Genomic DNA Translation: CAA03883.1
CCDSiCCDS31599.1 [Q15637-1]
CCDS44642.2 [Q15637-6]
CCDS53660.1 [Q15637-7]
CCDS53661.1 [Q15637-5]
CCDS8080.1 [Q15637-2]
CCDS8081.1 [Q15637-4]
PIRiG02919
RefSeqiNP_001171501.1, NM_001178030.1 [Q15637-5]
NP_001171502.1, NM_001178031.2 [Q15637-7]
NP_001333292.1, NM_001346363.1
NP_001333293.1, NM_001346364.1
NP_004621.2, NM_004630.3 [Q15637-1]
NP_973724.1, NM_201995.2 [Q15637-2]
NP_973727.1, NM_201998.2 [Q15637-4]
XP_016873733.1, XM_017018244.1 [Q15637-7]
UniGeneiHs.502829

Genome annotation databases

EnsembliENST00000227503; ENSP00000227503; ENSG00000168066 [Q15637-4]
ENST00000334944; ENSP00000334414; ENSG00000168066 [Q15637-2]
ENST00000377387; ENSP00000366604; ENSG00000168066 [Q15637-5]
ENST00000377390; ENSP00000366607; ENSG00000168066 [Q15637-1]
ENST00000377394; ENSP00000366611; ENSG00000168066 [Q15637-6]
ENST00000433274; ENSP00000396793; ENSG00000168066 [Q15637-7]
GeneIDi7536
KEGGihsa:7536
UCSCiuc001oaz.3 human [Q15637-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08765 mRNA Translation: CAA70018.1
Y08766 mRNA Translation: CAA70019.1
L49345 mRNA Translation: AAB03514.1
L49380 mRNA Translation: AAB04033.1
D26120 mRNA Translation: BAA05116.1
D26120 mRNA Translation: BAA05117.1
AK293753 mRNA Translation: BAH11587.1
AP001462 Genomic DNA No translation available.
BC000773 mRNA Translation: AAH00773.1 Different initiation.
BC008080 mRNA Translation: AAH08080.1
BC008724 mRNA Translation: AAH08724.1
BC011657 mRNA No translation available.
BC020217 mRNA Translation: AAH20217.1
BC038446 mRNA Translation: AAH38446.1
AJ000051, AJ000052 Genomic DNA Translation: CAA03883.1
CCDSiCCDS31599.1 [Q15637-1]
CCDS44642.2 [Q15637-6]
CCDS53660.1 [Q15637-7]
CCDS53661.1 [Q15637-5]
CCDS8080.1 [Q15637-2]
CCDS8081.1 [Q15637-4]
PIRiG02919
RefSeqiNP_001171501.1, NM_001178030.1 [Q15637-5]
NP_001171502.1, NM_001178031.2 [Q15637-7]
NP_001333292.1, NM_001346363.1
NP_001333293.1, NM_001346364.1
NP_004621.2, NM_004630.3 [Q15637-1]
NP_973724.1, NM_201995.2 [Q15637-2]
NP_973727.1, NM_201998.2 [Q15637-4]
XP_016873733.1, XM_017018244.1 [Q15637-7]
UniGeneiHs.502829

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K1GNMR-A133-260[»]
1O0PNMR-B13-25[»]
1OPINMR-B13-25[»]
2M09NMR-A27-145[»]
2M0GNMR-A1-145[»]
4FXWX-ray2.29B/D14-132[»]
4FXXX-ray2.48A/B/C/D26-132[»]
ProteinModelPortaliQ15637
SMRiQ15637
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113368, 156 interactors
CORUMiQ15637
DIPiDIP-29410N
ELMiQ15637
IntActiQ15637, 210 interactors
MINTiQ15637
STRINGi9606.ENSP00000366604

Protein family/group databases

MoonDBiQ15637 Predicted

PTM databases

iPTMnetiQ15637
PhosphoSitePlusiQ15637
SwissPalmiQ15637

Polymorphism and mutation databases

BioMutaiSF1
DMDMi38258418

Proteomic databases

EPDiQ15637
MaxQBiQ15637
PaxDbiQ15637
PeptideAtlasiQ15637
PRIDEiQ15637
ProteomicsDBi60669
60670 [Q15637-2]
60671 [Q15637-3]
60672 [Q15637-4]
60673 [Q15637-5]
60674 [Q15637-6]
TopDownProteomicsiQ15637-4 [Q15637-4]

Protocols and materials databases

DNASUi7536
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227503; ENSP00000227503; ENSG00000168066 [Q15637-4]
ENST00000334944; ENSP00000334414; ENSG00000168066 [Q15637-2]
ENST00000377387; ENSP00000366604; ENSG00000168066 [Q15637-5]
ENST00000377390; ENSP00000366607; ENSG00000168066 [Q15637-1]
ENST00000377394; ENSP00000366611; ENSG00000168066 [Q15637-6]
ENST00000433274; ENSP00000396793; ENSG00000168066 [Q15637-7]
GeneIDi7536
KEGGihsa:7536
UCSCiuc001oaz.3 human [Q15637-1]

Organism-specific databases

CTDi7536
DisGeNETi7536
EuPathDBiHostDB:ENSG00000168066.20
GeneCardsiSF1
HGNCiHGNC:12950 SF1
HPAiHPA018883
MIMi601516 gene
neXtProtiNX_Q15637
OpenTargetsiENSG00000168066
PharmGKBiPA37533
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0119 Eukaryota
COG5176 LUCA
GeneTreeiENSGT00550000074434
HOGENOMiHOG000237321
HOVERGENiHBG063318
InParanoidiQ15637
KOiK13095
OMAiPPLMPWM
OrthoDBiEOG091G0AEL
PhylomeDBiQ15637
TreeFamiTF319159

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
SIGNORiQ15637

Miscellaneous databases

ChiTaRSiSF1 human
EvolutionaryTraceiQ15637
GeneWikiiSF1_(gene)
GenomeRNAii7536
PROiPR:Q15637
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168066 Expressed in 242 organ(s), highest expression level in testis
CleanExiHS_SF1
ExpressionAtlasiQ15637 baseline and differential
GenevisibleiQ15637 HS

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR031150 BBP/SF1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR032570 SF1-HH
IPR001878 Znf_CCHC
PANTHERiPTHR11208:SF45 PTHR11208:SF45, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF16275 SF1-HH, 1 hit
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSF01_HUMAN
AccessioniPrimary (citable) accession number: Q15637
Secondary accession number(s): B7Z1Q1
, C9JJE2, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 193 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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