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Entry version 185 (18 Sep 2019)
Sequence version 3 (14 Oct 2008)
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Protein

RISC-loading complex subunit TARBP2

Gene

TARBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.UniRule annotation7 Publications
(Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:2011739, PubMed:11438532, PubMed:12475984). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973).4 Publications

Caution

A paper describing truncating mutations of TARBP2 in tumor cells and resultant effects on DICER1 stability and miRNA processing has been retracted, due to concerns of image duplication in some of the figures.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processRNA-mediated gene silencing, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-426486 Small interfering RNA (siRNA) biogenesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q15633

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RISC-loading complex subunit TARBP2UniRule annotation
Alternative name(s):
TAR RNA-binding protein 2
Trans-activation-responsive RNA-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TARBP2UniRule annotation
Synonyms:TRBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:11569 TARBP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605053 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15633

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6895

Open Targets

More...
OpenTargetsi
ENSG00000139546

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36334

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TARBP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000656221 – 366RISC-loading complex subunit TARBP2Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei152PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15633

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15633

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15633

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15633

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15633

PeptideAtlas

More...
PeptideAtlasi
Q15633

PRoteomics IDEntifications database

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PRIDEi
Q15633

ProteomicsDB human proteome resource

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ProteomicsDBi
60666 [Q15633-1]
60667 [Q15633-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15633

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15633

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000139546 Expressed in 170 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15633 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15633 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB069406
HPA051181
HPA061454

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates.

Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC.

Interacts with EIF2AK2/PKR and inhibits its protein kinase activity.

Interacts with DHX9 and PRKRA.

Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).

UniRule annotation11 Publications

(Microbial infection)

Interacts with FTSJ3; forms a complex with FTSJ3 and HIV-1 TAR RNA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112758, 81 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-134 RISC-loading complex, TARBP2 variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q15633

Database of interacting proteins

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DIPi
DIP-29665N

Protein interaction database and analysis system

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IntActi
Q15633, 50 interactors

Molecular INTeraction database

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MINTi
Q15633

STRING: functional protein association networks

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STRINGi
9606.ENSP00000266987

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15633

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q15633

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 97DRBM 1UniRule annotationAdd BLAST68
Domaini159 – 227DRBM 2UniRule annotationAdd BLAST69
Domaini293 – 361DRBM 3UniRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 105Sufficient for interaction with PRKRAAdd BLAST84
Regioni152 – 234Sufficient for interaction with PRKRAAdd BLAST83
Regioni228 – 366Sufficient for interaction with DICER1Add BLAST139
Regioni287 – 366Sufficient for interaction with PRKRAAdd BLAST80

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TARBP2 family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3732 Eukaryota
ENOG410XSCK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157748

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231919

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15633

KEGG Orthology (KO)

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KOi
K18420

Identification of Orthologs from Complete Genome Data

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OMAi
QPITVCH

Database of Orthologous Groups

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OrthoDBi
1093169at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15633

TreeFam database of animal gene trees

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TreeFami
TF315953

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_03034 TRBP2, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014720 dsRBD_dom
IPR028605 TRBP2

The PANTHER Classification System

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PANTHERi
PTHR46205:SF1 PTHR46205:SF1, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00035 dsrm, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00358 DSRM, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50137 DS_RBD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15633-1) [UniParc]FASTAAdd to basket
Also known as: TRBP2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEEEQGSGT TTGCGLPSIE QMLAANPGKT PISLLQEYGT RIGKTPVYDL
60 70 80 90 100
LKAEGQAHQP NFTFRVTVGD TSCTGQGPSK KAAKHKAAEV ALKHLKGGSM
110 120 130 140 150
LEPALEDSSS FSPLDSSLPE DIPVFTAAAA ATPVPSVVLT RSPPMELQPP
160 170 180 190 200
VSPQQSECNP VGALQELVVQ KGWRLPEYTV TQESGPAHRK EFTMTCRVER
210 220 230 240 250
FIEIGSGTSK KLAKRNAAAK MLLRVHTVPL DARDGNEVEP DDDHFSIGVG
260 270 280 290 300
SRLDGLRNRG PGCTWDSLRN SVGEKILSLR SCSLGSLGAL GPACCRVLSE
310 320 330 340 350
LSEEQAFHVS YLDIEELSLS GLCQCLVELS TQPATVCHGS ATTREAARGE
360
AARRALQYLK IMAGSK
Length:366
Mass (Da):39,039
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i768BA11751DA4912
GO
Isoform 2 (identifier: Q15633-2) [UniParc]FASTAAdd to basket
Also known as: TRBP1

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:345
Mass (Da):36,916
Checksum:i7506A9324E9D0596
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VZ57F8VZ57_HUMAN
RISC-loading complex subunit TARBP2
TARBP2
227Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV98H3BV98_HUMAN
RISC-loading complex subunit TARBP2
TARBP2
160Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VW32F8VW32_HUMAN
RISC-loading complex subunit TARBP2
TARBP2
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYK6F8VYK6_HUMAN
RISC-loading complex subunit TARBP2
TARBP2
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZZ7F8VZZ7_HUMAN
RISC-loading complex subunit TARBP2
TARBP2
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VP94F8VP94_HUMAN
RISC-loading complex subunit TARBP2
TARBP2
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYK3F8VYK3_HUMAN
RISC-loading complex subunit TARBP2
TARBP2
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VTT7F8VTT7_HUMAN
RISC-loading complex subunit TARBP2
TARBP2
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VSA1F8VSA1_HUMAN
RISC-loading complex subunit TARBP2
TARBP2
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144P → A in AAA36765 (PubMed:2011739).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046992251S → F2 PublicationsCorresponds to variant dbSNP:rs1126500Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0355841 – 21Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M60801 mRNA Translation: AAA36765.1
U08998 mRNA Translation: AAB50581.2
BT007140 mRNA Translation: AAP35804.1
CH471054 Genomic DNA Translation: EAW96720.1
BC005860 mRNA Translation: AAH05860.1
AF281068 Genomic DNA Translation: AAL55730.1
AF281068 Genomic DNA Translation: AAL55731.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41791.1 [Q15633-2]
CCDS8861.1 [Q15633-1]

Protein sequence database of the Protein Information Resource

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PIRi
G01420

NCBI Reference Sequences

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RefSeqi
NP_004169.3, NM_004178.4 [Q15633-2]
NP_599150.1, NM_134323.1 [Q15633-1]
NP_599151.2, NM_134324.2 [Q15633-2]
XP_005269171.1, XM_005269114.1 [Q15633-2]
XP_005269172.1, XM_005269115.2 [Q15633-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000266987; ENSP00000266987; ENSG00000139546 [Q15633-1]
ENST00000394357; ENSP00000377885; ENSG00000139546 [Q15633-2]
ENST00000456234; ENSP00000416077; ENSG00000139546 [Q15633-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6895

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6895

UCSC genome browser

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UCSCi
uc001sdo.4 human [Q15633-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60801 mRNA Translation: AAA36765.1
U08998 mRNA Translation: AAB50581.2
BT007140 mRNA Translation: AAP35804.1
CH471054 Genomic DNA Translation: EAW96720.1
BC005860 mRNA Translation: AAH05860.1
AF281068 Genomic DNA Translation: AAL55730.1
AF281068 Genomic DNA Translation: AAL55731.1
CCDSiCCDS41791.1 [Q15633-2]
CCDS8861.1 [Q15633-1]
PIRiG01420
RefSeqiNP_004169.3, NM_004178.4 [Q15633-2]
NP_599150.1, NM_134323.1 [Q15633-1]
NP_599151.2, NM_134324.2 [Q15633-2]
XP_005269171.1, XM_005269114.1 [Q15633-2]
XP_005269172.1, XM_005269115.2 [Q15633-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPNNMR-A150-225[»]
3ADLX-ray2.20A161-231[»]
3LLHX-ray2.14A/B22-105[»]
4WYQX-ray3.20B/E289-363[»]
5N8LNMR-A16-227[»]
5N8MNMR-A16-227[»]
5ZAKelectron microscopy4.40B1-366[»]
5ZALelectron microscopy4.70B1-366[»]
5ZAMelectron microscopy5.70B1-366[»]
SMRiQ15633
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112758, 81 interactors
ComplexPortaliCPX-134 RISC-loading complex, TARBP2 variant
CORUMiQ15633
DIPiDIP-29665N
IntActiQ15633, 50 interactors
MINTiQ15633
STRINGi9606.ENSP00000266987

PTM databases

iPTMnetiQ15633
PhosphoSitePlusiQ15633

Polymorphism and mutation databases

BioMutaiTARBP2
DMDMi209572714

Proteomic databases

EPDiQ15633
jPOSTiQ15633
MassIVEiQ15633
MaxQBiQ15633
PaxDbiQ15633
PeptideAtlasiQ15633
PRIDEiQ15633
ProteomicsDBi60666 [Q15633-1]
60667 [Q15633-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6895
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266987; ENSP00000266987; ENSG00000139546 [Q15633-1]
ENST00000394357; ENSP00000377885; ENSG00000139546 [Q15633-2]
ENST00000456234; ENSP00000416077; ENSG00000139546 [Q15633-2]
GeneIDi6895
KEGGihsa:6895
UCSCiuc001sdo.4 human [Q15633-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6895
DisGeNETi6895

GeneCards: human genes, protein and diseases

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GeneCardsi
TARBP2
HGNCiHGNC:11569 TARBP2
HPAiCAB069406
HPA051181
HPA061454
MIMi605053 gene
neXtProtiNX_Q15633
OpenTargetsiENSG00000139546
PharmGKBiPA36334

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3732 Eukaryota
ENOG410XSCK LUCA
GeneTreeiENSGT00940000157748
HOGENOMiHOG000231919
InParanoidiQ15633
KOiK18420
OMAiQPITVCH
OrthoDBi1093169at2759
PhylomeDBiQ15633
TreeFamiTF315953

Enzyme and pathway databases

ReactomeiR-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-426486 Small interfering RNA (siRNA) biogenesis
SIGNORiQ15633

Miscellaneous databases

EvolutionaryTraceiQ15633

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TARBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6895

Pharos

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Pharosi
Q15633

Protein Ontology

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PROi
PR:Q15633

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000139546 Expressed in 170 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ15633 baseline and differential
GenevisibleiQ15633 HS

Family and domain databases

CDDicd00048 DSRM, 2 hits
HAMAPiMF_03034 TRBP2, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR028605 TRBP2
PANTHERiPTHR46205:SF1 PTHR46205:SF1, 1 hit
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
SMARTiView protein in SMART
SM00358 DSRM, 3 hits
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRBP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15633
Secondary accession number(s): Q12878
, Q8WY32, Q8WY33, Q9BRY2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: September 18, 2019
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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