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UniProtKB - Q15631 (TSN_HUMAN)

Entry version 177 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Translin

Gene

TSN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease, RNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15631

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-426486, Small interfering RNA (siRNA) biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translin (EC:3.1.-.-)
Alternative name(s):
Component 3 of promoter of RISC
Short name:
C3PO
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000211460.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:12379, TSN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600575, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15631

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7247

Open Targets

More...OpenTargetsi		ENSG00000211460

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37047

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15631, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TSN

Domain mapping of disease mutations (DMDM)

More...DMDMi		6136060

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001916831 – 228TranslinAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei187N6-acetyllysineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei199N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15631

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15631

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15631

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15631

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15631

PeptideAtlas

More...PeptideAtlasi		Q15631

PRoteomics IDEntifications database

More...PRIDEi		Q15631

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60665 [Q15631-1]
6554

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q15631-1 [Q15631-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15631

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15631

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000211460, Expressed in female gonad and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15631, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15631, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000211460, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113098, 38 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-890, C3PO endoribonuclease complex

Database of interacting proteins

More...DIPi		DIP-42216N

Protein interaction database and analysis system

More...IntActi		Q15631, 17 interactors

Molecular INTeraction database

More...MINTi		Q15631

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000374332

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15631, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15631

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15631

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni86 – 90DNA/RNA binding5
Regioni177 – 198Leucine-zipperSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the translin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3067, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153568

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_079179_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15631

Identification of Orthologs from Complete Genome Data

More...OMAi		SIELCAW

Database of Orthologous Groups

More...OrthoDBi		1187354at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15631

TreeFam database of animal gene trees

More...TreeFami		TF323690

Family and domain databases

Conserved Domains Database

More...CDDi		cd14819, Translin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.190, 1 hit
1.20.58.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033956, Translin
IPR016069, Translin_C
IPR002848, Translin_fam
IPR016068, Translin_N
IPR036081, Translin_sf

The PANTHER Classification System

More...PANTHERi		PTHR10741, PTHR10741, 1 hit
PTHR10741:SF2, PTHR10741:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01997, Translin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF74784, SSF74784, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15631-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVSEIFVEL QGFLAAEQDI REEIRKVVQS LEQTAREILT LLQGVHQGAG 
        60         70         80         90        100
FQDIPKRCLK AREHFGTVKT HLTSLKTKFP AEQYYRFHEH WRFVLQRLVF 
       110        120        130        140        150
LAAFVVYLET ETLVTREAVT EILGIEPDRE KGFHLDVEDY LSGVLILASE 
       160        170        180        190        200
LSRLSVNSVT AGDYSRPLHI STFINELDSG FRLLNLKNDS LRKRYDGLKY 
       210        220 
DVKKVEEVVY DLSIRGFNKE TAAACVEK
Length:228
Mass (Da):26,183
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CAAF20BED7C4939
GO
Isoform 2 (identifier: Q15631-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-148: PDREKGFHLDVEDYLSGVLILA → AVCQQRDCWRLLPTPPHLHLHQ
     149-228: Missing.

Show »
Length:148
Mass (Da):17,279
Checksum:i475F177A67256825
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGT1E9PGT1_HUMAN
Component 3 of promoter of RISC
TSN
223Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1D4H7C1D4_HUMAN
Component 3 of promoter of RISC
TSN
185Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVW2A0A0J9YVW2_HUMAN
Translin
TSN
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX41A0A0J9YX41_HUMAN
Translin
TSN
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044937127 – 148PDREK…VLILA → AVCQQRDCWRLLPTPPHLHL HQ in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_044938149 – 228Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X78627 mRNA Translation: CAA55341.1
BT019490 mRNA Translation: AAV38297.1
BT019491 mRNA Translation: AAV38298.1
AK296469 mRNA Translation: BAH12364.1
AC018737 Genomic DNA Translation: AAY14831.1
BC002359 mRNA Translation: AAH02359.1
Y12563 Y12567 Genomic DNA Translation: CAA73150.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33284.1 [Q15631-1]
CCDS58723.1 [Q15631-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S51738

NCBI Reference Sequences

More...RefSeqi		NP_001248330.1, NM_001261401.1 [Q15631-2]
NP_004613.1, NM_004622.2 [Q15631-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000389682; ENSP00000374332; ENSG00000211460 [Q15631-1]
ENST00000536142; ENSP00000437728; ENSG00000211460 [Q15631-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7247

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7247

UCSC genome browser

More...UCSCi		uc002tnl.4, human [Q15631-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78627 mRNA Translation: CAA55341.1
BT019490 mRNA Translation: AAV38297.1
BT019491 mRNA Translation: AAV38298.1
AK296469 mRNA Translation: BAH12364.1
AC018737 Genomic DNA Translation: AAY14831.1
BC002359 mRNA Translation: AAH02359.1
Y12563 Y12567 Genomic DNA Translation: CAA73150.1
CCDSiCCDS33284.1 [Q15631-1]
CCDS58723.1 [Q15631-2]
PIRiS51738
RefSeqiNP_001248330.1, NM_001261401.1 [Q15631-2]
NP_004613.1, NM_004622.2 [Q15631-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J1JX-ray2.20A/B/C/D1-228[»]
3PJAX-ray3.00A/B/C/D/E/F/G/H/I1-228[»]
3QB5X-ray2.95A/B/C1-228[»]
4WYVX-ray3.00A/B/C/D/E/F/G/H1-228[»]
SMRiQ15631
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113098, 38 interactors
ComplexPortaliCPX-890, C3PO endoribonuclease complex
DIPiDIP-42216N
IntActiQ15631, 17 interactors
MINTiQ15631
STRINGi9606.ENSP00000374332

PTM databases

iPTMnetiQ15631
PhosphoSitePlusiQ15631

Polymorphism and mutation databases

BioMutaiTSN
DMDMi6136060

Proteomic databases

EPDiQ15631
jPOSTiQ15631
MassIVEiQ15631
MaxQBiQ15631
PaxDbiQ15631
PeptideAtlasiQ15631
PRIDEiQ15631
ProteomicsDBi60665 [Q15631-1]
6554
TopDownProteomicsiQ15631-1 [Q15631-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33410, 213 antibodies

The DNASU plasmid repository

More...DNASUi		7247

Genome annotation databases

EnsembliENST00000389682; ENSP00000374332; ENSG00000211460 [Q15631-1]
ENST00000536142; ENSP00000437728; ENSG00000211460 [Q15631-2]
GeneIDi7247
KEGGihsa:7247
UCSCiuc002tnl.4, human [Q15631-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7247
DisGeNETi7247
EuPathDBiHostDB:ENSG00000211460.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		TSN
HGNCiHGNC:12379, TSN
HPAiENSG00000211460, Low tissue specificity
MIMi600575, gene
neXtProtiNX_Q15631
OpenTargetsiENSG00000211460
PharmGKBiPA37047

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3067, Eukaryota
GeneTreeiENSGT00940000153568
HOGENOMiCLU_079179_0_0_1
InParanoidiQ15631
OMAiSIELCAW
OrthoDBi1187354at2759
PhylomeDBiQ15631
TreeFamiTF323690

Enzyme and pathway databases

PathwayCommonsiQ15631
ReactomeiR-HSA-426486, Small interfering RNA (siRNA) biogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7247, 2 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TSN, human
EvolutionaryTraceiQ15631

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TSN_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7247
PharosiQ15631, Tbio

Protein Ontology

More...PROi		PR:Q15631
RNActiQ15631, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000211460, Expressed in female gonad and 251 other tissues
ExpressionAtlasiQ15631, baseline and differential
GenevisibleiQ15631, HS

Family and domain databases

CDDicd14819, Translin, 1 hit
Gene3Di1.20.58.190, 1 hit
1.20.58.200, 1 hit
InterProiView protein in InterPro
IPR033956, Translin
IPR016069, Translin_C
IPR002848, Translin_fam
IPR016068, Translin_N
IPR036081, Translin_sf
PANTHERiPTHR10741, PTHR10741, 1 hit
PTHR10741:SF2, PTHR10741:SF2, 1 hit
PfamiView protein in Pfam
PF01997, Translin, 1 hit
SUPFAMiSSF74784, SSF74784, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15631
Secondary accession number(s): B7Z3X8, Q5U0K7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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