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Protein

Translocating chain-associated membrane protein 1

Gene

TRAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulatory or required for the translocation of secretory proteins across the ER membrane.

GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

  • cotranslational protein targeting to membrane Source: ProtInc
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processHost-virus interaction, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Translocating chain-associated membrane protein 1
Gene namesi
Name:TRAM1
Synonyms:TRAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000067167.7
HGNCiHGNC:20568 TRAM1
MIMi605190 gene
neXtProtiNX_Q15629

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 76LumenalSequence analysisAdd BLAST26
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 121CytoplasmicSequence analysisAdd BLAST24
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 159LumenalSequence analysisAdd BLAST17
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 192CytoplasmicSequence analysisAdd BLAST12
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 217LumenalSequence analysis4
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 251CytoplasmicSequence analysisAdd BLAST13
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 297LumenalSequence analysisAdd BLAST25
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 374CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23471
OpenTargetsiENSG00000067167
PharmGKBiPA134955644

Polymorphism and mutation databases

BioMutaiTRAM1
DMDMi18202507

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855301 – 374Translocating chain-associated membrane protein 1Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineCurated1
Modified residuei365PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15629
PaxDbiQ15629
PeptideAtlasiQ15629
PRIDEiQ15629
ProteomicsDBi60664
TopDownProteomicsiQ15629-1 [Q15629-1]

PTM databases

iPTMnetiQ15629
PhosphoSitePlusiQ15629
SwissPalmiQ15629

Expressioni

Gene expression databases

BgeeiENSG00000067167
CleanExiHS_TRAM1
ExpressionAtlasiQ15629 baseline and differential
GenevisibleiQ15629 HS

Organism-specific databases

HPAiHPA023929

Interactioni

Subunit structurei

(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein US2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCAP31P515725EBI-1788852,EBI-77683

Protein-protein interaction databases

BioGridi117032, 22 interactors
DIPiDIP-45978N
IntActiQ15629, 22 interactors
MINTiQ15629
STRINGi9606.ENSP00000262213

Structurei

3D structure databases

ProteinModelPortaliQ15629
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 326TLCPROSITE-ProRule annotationAdd BLAST210

Sequence similaritiesi

Belongs to the TRAM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1608 Eukaryota
ENOG410XSB3 LUCA
GeneTreeiENSGT00510000046470
HOGENOMiHOG000007494
HOVERGENiHBG054402
InParanoidiQ15629
KOiK14010
OMAiYLFSCIW
OrthoDBiEOG091G077N
PhylomeDBiQ15629
TreeFamiTF314319

Family and domain databases

InterProiView protein in InterPro
IPR006634 TLC-dom
IPR013599 TRAM1
IPR016447 Translocation_assoc_membrane
PfamiView protein in Pfam
PF08390 TRAM1, 1 hit
PF03798 TRAM_LAG1_CLN8, 1 hit
PIRSFiPIRSF005449 Translocation_assoc_membrane, 1 hit
SMARTiView protein in SMART
SM00724 TLC, 1 hit
PROSITEiView protein in PROSITE
PS50922 TLC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15629-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIRKKSTKS PPVLSHEFVL QNHADIVSCV AMVFLLGLMF EITAKASIIF
60 70 80 90 100
VTLQYNVTLP ATEEQATESV SLYYYGIKDL ATVFFYMLVA IIIHAVIQEY
110 120 130 140 150
MLDKINRRMH FSKTKHSKFN ESGQLSAFYL FACVWGTFIL ISENYISDPT
160 170 180 190 200
ILWRAYPHNL MTFQMKFFYI SQLAYWLHAF PELYFQKTKK EDIPRQLVYI
210 220 230 240 250
GLYLFHIAGA YLLNLNHLGL VLLVLHYFVE FLFHISRLFY FSNEKYQKGF
260 270 280 290 300
SLWAVLFVLG RLLTLILSVL TVGFGLARAE NQKLDFSTGN FNVLAVRIAV
310 320 330 340 350
LASICVTQAF MMWKFINFQL RRWREHSAFQ APAVKKKPTV TKGRSSKKGT
360 370
ENGVNGTLTS NVADSPRNKK EKSS
Length:374
Mass (Da):43,072
Last modified:January 23, 2007 - v3
Checksum:i9232ADA33DE20076
GO
Isoform 2 (identifier: Q15629-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Note: No experimental confirmation available.
Show »
Length:343
Mass (Da):39,683
Checksum:i14266BD8762EF466
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562131 – 31Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63679 mRNA Translation: CAA45218.1
AK303411 mRNA Translation: BAG64464.1
AC022731 Genomic DNA No translation available.
AC120194 Genomic DNA No translation available.
BC000687 mRNA Translation: AAH00687.1
BC037738 mRNA Translation: AAH37738.1
CCDSiCCDS6207.1 [Q15629-1]
PIRiS30034
RefSeqiNP_001304733.1, NM_001317804.1 [Q15629-2]
NP_001304734.1, NM_001317805.1
NP_055109.1, NM_014294.5 [Q15629-1]
UniGeneiHs.491988

Genome annotation databases

EnsembliENST00000262213; ENSP00000262213; ENSG00000067167 [Q15629-1]
GeneIDi23471
KEGGihsa:23471

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRAM1_HUMAN
AccessioniPrimary (citable) accession number: Q15629
Secondary accession number(s): B4E0K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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