TRADD

Functionⁱ

The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.By similarity

GO - Molecular functionⁱ

death domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8612133
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 11684708
- 7758105
kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8612133
molecular adaptor activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8612133
protein-containing complex binding Source: Ensembl
tumor necrosis factor receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 7758105
death-inducing signaling complex assembly Source: Reactome
extrinsic apoptotic signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16611992
extrinsic apoptotic signaling pathway via death domain receptors
Source: BHF-UCL
Traceable author statementⁱ
- 8612133
I-kappaB kinase/NF-kappaB signaling Source: Reactome
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Reactome
positive regulation of apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 18309324
positive regulation of hair follicle development Source: Ensembl
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from expression patternⁱ
- 12761501
positive regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Traceable author statementⁱ
- 18309324
protein heterooligomerization Source: Ensembl
regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Reactome
regulation of tumor necrosis factor-mediated signaling pathway Source: Reactome
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7758105
tumor necrosis factor-mediated signaling pathway
Source: BHF-UCL
Traceable author statementⁱ
- 8612133

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-140534 via Death Receptors in the presence of ligand R-HSA-3371378 Regulation by c-FLIP R-HSA-5213460 RIPK1-mediated regulated necrosis R-HSA-5218900 CASP8 activity is inhibited R-HSA-5357786 TNFR1-induced proapoptotic signaling R-HSA-5357905 Regulation of TNFR1 signaling R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway R-HSA-5675482 Regulation of necroptotic cell death R-HSA-69416 Dimerization of procaspase-8 R-HSA-75893 TNF signaling
SignaLinkⁱ	Q15628
SIGNORⁱ	Q15628

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor type 1-associated DEATH domain protein Short name: TNFR1-associated DEATH domain protein Alternative name(s): TNFRSF1A-associated via death domain
Gene namesⁱ	Name:TRADD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102871.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12030 TRADD
MIMⁱ	603500 gene
neXtProtⁱ	NX_Q15628

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8717
Open Targets More...OpenTargetsⁱ	ENSG00000102871
PharmGKBⁱ	PA36707

Polymorphism and mutation databases

BioMutaⁱ	TRADD
DMDMⁱ	6094511

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000065602	1 – 312	Tumor necrosis factor receptor type 1-associated DEATH domain proteinAdd BLAST		312

Proteomic databases

EPDⁱ	Q15628
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15628
PaxDbⁱ	Q15628
PeptideAtlas More...PeptideAtlasⁱ	Q15628
PRIDEⁱ	Q15628
ProteomicsDBⁱ	60663

PTM databases

iPTMnetⁱ	Q15628
PhosphoSitePlusⁱ	Q15628

Expressionⁱ

Tissue specificityⁱ

Found in all examined tissues.

Gene expression databases

Bgeeⁱ	ENSG00000102871 Expressed in 213 organ(s), highest expression level in blood
CleanExⁱ	HS_TRADD
Genevisibleⁱ	Q15628 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004602 HPA071341

HPAⁱ

CAB004602
HPA071341

Interactionⁱ

Subunit structureⁱ

Stimulation of TNF-alpha receptor TNFRSF1A leads to the formation of two distinct signaling complexes. Plasma membrane-bound complex I is composed of TNFRSF1A, TRADD, RIPK1, TRAF2 and BIRC2/c-IAP1 or BIRC3 which interacts with CHUCK/IKK-alpha, IKBKB/IKK-beta and IKBKG/IKK-gamma promoting cell survival (PubMed:7758105, PubMed:8612133, PubMed:14585990, PubMed:21307340). Subsequently, TRADD, RIPK1 and TRAF2 dissociate from TNFRSF1A and form cytoplasmic complex II with FADD and caspase CASP8 promoting cell apoptosis (PubMed:21307340). Within complex I, interacts with TNFRSF1A/TNFR1, TRAF2 and kinase RIPK1 (PubMed:7758105, PubMed:10892748, PubMed:8612133). Within complex I, interacts with TRPC4AP; the interaction promotes NF-kappa B activation (PubMed:14585990). UXT1 associates with complex I; the interaction prevents the formation of complex II (PubMed:21307340). Within complex I Interacts with scaffold protein DAB2IP (PubMed:15310755). Interacts with autophagy receptor SQSTM1 (PubMed:10356400). Interacts with E3 ligase TRIP12 (By similarity). Interacts with kinase HIPK2 (PubMed:11032752). Interacts with keratin KRT14 (PubMed:11684708). Interacts with keratin KRT18 (PubMed:11684708). Interacts with keratins KRT16 and KRT17 (By similarity).By similarity10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-359215,EBI-359215
E2348C_3231	B7UI21	7	EBI-359215,EBI-16070376	From Escherichia coli O127:H6 (strain E2348/69 / EPEC).
FADD	Q13158	4	EBI-359215,EBI-494804
KRT18	P05783	11	EBI-359215,EBI-297888
LMP1	P03230	4	EBI-359215,EBI-6973030	From Epstein-Barr virus (strain B95-8).
TNFRSF1A	P19438	13	EBI-359215,EBI-299451
TRAF2	Q12933	8	EBI-359215,EBI-355744

GO - Molecular functionⁱ

death domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8612133
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 11684708
- 7758105
kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8612133
tumor necrosis factor receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114257, 44 interactors
CORUMⁱ	Q15628
Database of interacting proteins More...DIPⁱ	DIP-285N
IntActⁱ	Q15628, 21 interactors
Molecular INTeraction database More...MINTⁱ	Q15628
STRINGⁱ	9606.ENSP00000341268

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	12 – 25	Combined sources	14
Helixⁱ	28 – 33	Combined sources	6
Turnⁱ	35 – 37	Combined sources	3
Helixⁱ	38 – 52	Combined sources	15
Turnⁱ	56 – 58	Combined sources	3
Beta strandⁱ	59 – 66	Combined sources	8
Beta strandⁱ	68 – 79	Combined sources	12
Helixⁱ	80 – 91	Combined sources	12
Helixⁱ	94 – 106	Combined sources	13
Beta strandⁱ	114 – 120	Combined sources	7
Helixⁱ	125 – 128	Combined sources	4
Helixⁱ	132 – 141	Combined sources	10
Helixⁱ	150 – 162	Combined sources	13
Beta strandⁱ	201 – 204	Combined sources	4
Beta strandⁱ	207 – 210	Combined sources	4
Helixⁱ	216 – 226	Combined sources	11
Helixⁱ	227 – 229	Combined sources	3
Helixⁱ	230 – 240	Combined sources	11
Helixⁱ	242 – 244	Combined sources	3
Helixⁱ	248 – 255	Combined sources	8
Turnⁱ	257 – 259	Combined sources	3
Helixⁱ	261 – 275	Combined sources	15
Beta strandⁱ	277 – 279	Combined sources	3
Helixⁱ	282 – 292	Combined sources	11
Helixⁱ	295 – 301	Combined sources	7
Beta strandⁱ	306 – 308	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15628
SMRⁱ	Q15628
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q15628

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	179 – 289	DeathPROSITE-ProRule annotationAdd BLAST		111

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	222 – 289	Interaction with KRT14 and KRT181 PublicationAdd BLAST		68

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	147 – 163	Nuclear export signalBy similarityAdd BLAST		17
Motifⁱ	231 – 244	Nuclear localization signalBy similarityAdd BLAST		14

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	192 – 198	Poly-Pro		7

Domainⁱ

Requires the intact death domain to associate with TNFRSF1A/TNFR1.

Phylogenomic databases

eggNOGⁱ	ENOG410IF81 Eukaryota ENOG4111IRA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002016
HOGENOMⁱ	HOG000059664
HOVERGENⁱ	HBG054083
InParanoidⁱ	Q15628
KEGG Orthology (KO) More...KOⁱ	K03171
OMAⁱ	FCGRQPC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DXR
PhylomeDBⁱ	Q15628
TreeFamⁱ	TF331882

Family and domain databases

Gene3Dⁱ	3.30.70.680, 1 hit
InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR035712 TRADD IPR009095 TRADD_N IPR036729 TRADD_N_sf
PANTHERⁱ	PTHR14913 PTHR14913, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF09034 TRADD_N, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD182470 TRADD_N, 1 hit
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit SSF55044 SSF55044, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q15628-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGQNGHEE WVGSAYLFVE SSLDKVVLSD AYAHPQQKVA VYRALQAALA 
        60         70         80         90        100
ESGGSPDVLQ MLKIHRSDPQ LIVQLRFCGR QPCGRFLRAY REGALRAALQ 
       110        120        130        140        150
RSLAAALAQH SVPLQLELRA GAERLDALLA DEERCLSCIL AQQPDRLRDE 
       160        170        180        190        200
ELAELEDALR NLKCGSGARG GDGEVASAPL QPPVPSLSEV KPPPPPPPAQ 
       210        220        230        240        250
TFLFQGQPVV NRPLSLKDQQ TFARSVGLKW RKVGRSLQRG CRALRDPALD 
       260        270        280        290        300
SLAYEYEREG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED 
       310 
LLGLTDPNGG LA

Length:312

Mass (Da):34,247

Last modified:July 15, 1999 - v2

Checksum:ⁱ5645D7E63E5FF05A

GO

Isoform 2 (identifier: Q15628-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-60: Missing.

« Hide

        10         20         30         40         50
MLKIHRSDPQ LIVQLRFCGR QPCGRFLRAY REGALRAALQ RSLAAALAQH 
        60         70         80         90        100
SVPLQLELRA GAERLDALLA DEERCLSCIL AQQPDRLRDE ELAELEDALR 
       110        120        130        140        150
NLKCGSGARG GDGEVASAPL QPPVPSLSEV KPPPPPPPAQ TFLFQGQPVV 
       160        170        180        190        200
NRPLSLKDQQ TFARSVGLKW RKVGRSLQRG CRALRDPALD SLAYEYEREG 
       210        220        230        240        250
LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED LLGLTDPNGG 

LA

Note: No experimental confirmation available.

Show »

Length:252

Mass (Da):27,904

Checksum:ⁱ669B381D012B108A

GO

Sequence cautionⁱ

The sequence AAA98482 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056526	1 – 60	Missing in isoform 2. 1 PublicationAdd BLAST		60

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L41690 mRNA Translation: AAA98482.1 Different initiation. AJ311614, AJ311615, AJ311616 Genomic DNA Translation: CAC38018.2 AY995114 Genomic DNA Translation: AAX89407.1 BT006934 mRNA Translation: AAP35580.1 AY575851 Genomic DNA Translation: AAS68637.1 AK090673 mRNA Translation: BAG52211.1 AK315654 mRNA Translation: BAG38020.1 AC074143 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83081.1 BC004491 mRNA Translation: AAH04491.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10829.1 [Q15628-1]
PIRⁱ	A56911
NCBI Reference Sequences More...RefSeqⁱ	NP_001310481.1, NM_001323552.1 [Q15628-1] NP_003780.1, NM_003789.3 [Q15628-1] XP_005256270.1, XM_005256213.3 [Q15628-2] XP_016879304.1, XM_017023815.1 [Q15628-1]
UniGeneⁱ	Hs.460996

Genome annotation databases

Ensemblⁱ	ENST00000345057; ENSP00000341268; ENSG00000102871 [Q15628-1] ENST00000486556; ENSP00000462591; ENSG00000102871 [Q15628-2]
GeneIDⁱ	8717
KEGGⁱ	hsa:8717
UCSC genome browser More...UCSCⁱ	uc002erh.2 human [Q15628-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15628	TNFRSF1A-associated via death domain		PANTR		312	UniRef100_Q15628
Isoform 2 of Tumor necrosis factor receptor type 1-associated DEATH domain protein		HUMAN		252
TRADD isoform 4		PANTR		252
UPI00001114E0		HUMAN		169
UPI00001114F5		HUMAN		179

Protein	Similar proteins		Species	Score	Length	Source
Q15628	TNFRSF1A-associated via death domain		PANTR		312	UniRef90_Q15628
Isoform 2 of Tumor necrosis factor receptor type 1-associated DEATH domain protein		HUMAN		252
Uncharacterized protein		NOMLE		311
Uncharacterized protein		PANPA		311
TRADD isoform 1		PONAB		311
+35

Protein	Similar proteins		Species	Score	Length	Source
Q15628	TNFRSF1A-associated via death domain		PANTR		312	UniRef50_Q15628
Isoform 2 of Tumor necrosis factor receptor type 1-associated DEATH domain protein		HUMAN		252
TRADD isoform 1		PONAB		311
Uncharacterized protein		NOMLE		311
Uncharacterized protein		PANPA		311
+77

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L41690 mRNA Translation: AAA98482.1 Different initiation. AJ311614, AJ311615, AJ311616 Genomic DNA Translation: CAC38018.2 AY995114 Genomic DNA Translation: AAX89407.1 BT006934 mRNA Translation: AAP35580.1 AY575851 Genomic DNA Translation: AAS68637.1 AK090673 mRNA Translation: BAG52211.1 AK315654 mRNA Translation: BAG38020.1 AC074143 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83081.1 BC004491 mRNA Translation: AAH04491.1
CCDSⁱ	CCDS10829.1 [Q15628-1]
PIRⁱ	A56911
RefSeqⁱ	NP_001310481.1, NM_001323552.1 [Q15628-1] NP_003780.1, NM_003789.3 [Q15628-1] XP_005256270.1, XM_005256213.3 [Q15628-2] XP_016879304.1, XM_017023815.1 [Q15628-1]
UniGeneⁱ	Hs.460996

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1F2H	NMR	-	A	1-169	[»]
	1F3V	X-ray	2.00	A	1-179	[»]
	5XME	NMR	-	A	199-312	[»]
ProteinModelPortalⁱ	Q15628
SMRⁱ	Q15628
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114257, 44 interactors
CORUMⁱ	Q15628
DIPⁱ	DIP-285N
IntActⁱ	Q15628, 21 interactors
MINTⁱ	Q15628
STRINGⁱ	9606.ENSP00000341268

PTM databases

iPTMnetⁱ	Q15628
PhosphoSitePlusⁱ	Q15628

Polymorphism and mutation databases

BioMutaⁱ	TRADD
DMDMⁱ	6094511

Proteomic databases

EPDⁱ	Q15628
MaxQBⁱ	Q15628
PaxDbⁱ	Q15628
PeptideAtlasⁱ	Q15628
PRIDEⁱ	Q15628
ProteomicsDBⁱ	60663

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8717
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000345057; ENSP00000341268; ENSG00000102871 [Q15628-1] ENST00000486556; ENSP00000462591; ENSG00000102871 [Q15628-2]
GeneIDⁱ	8717
KEGGⁱ	hsa:8717
UCSCⁱ	uc002erh.2 human [Q15628-1]

Organism-specific databases

CTDⁱ	8717
DisGeNETⁱ	8717
EuPathDBⁱ	HostDB:ENSG00000102871.15
GeneCardsⁱ	TRADD
HGNCⁱ	HGNC:12030 TRADD
HPAⁱ	CAB004602 HPA071341
MIMⁱ	603500 gene
neXtProtⁱ	NX_Q15628
OpenTargetsⁱ	ENSG00000102871
PharmGKBⁱ	PA36707
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF81 Eukaryota ENOG4111IRA LUCA
GeneTreeⁱ	ENSGT00390000002016
HOGENOMⁱ	HOG000059664
HOVERGENⁱ	HBG054083
InParanoidⁱ	Q15628
KOⁱ	K03171
OMAⁱ	FCGRQPC
OrthoDBⁱ	EOG091G0DXR
PhylomeDBⁱ	Q15628
TreeFamⁱ	TF331882

Enzyme and pathway databases

Reactomeⁱ	R-HSA-140534 via Death Receptors in the presence of ligand R-HSA-3371378 Regulation by c-FLIP R-HSA-5213460 RIPK1-mediated regulated necrosis R-HSA-5218900 CASP8 activity is inhibited R-HSA-5357786 TNFR1-induced proapoptotic signaling R-HSA-5357905 Regulation of TNFR1 signaling R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway R-HSA-5675482 Regulation of necroptotic cell death R-HSA-69416 Dimerization of procaspase-8 R-HSA-75893 TNF signaling
SignaLinkⁱ	Q15628
SIGNORⁱ	Q15628

Miscellaneous databases

EvolutionaryTraceⁱ	Q15628
GeneWikiⁱ	TRADD
GenomeRNAiⁱ	8717
Protein Ontology More...PROⁱ	PR:Q15628
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102871 Expressed in 213 organ(s), highest expression level in blood
CleanExⁱ	HS_TRADD
Genevisibleⁱ	Q15628 HS

Family and domain databases

Gene3Dⁱ	3.30.70.680, 1 hit
InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR035712 TRADD IPR009095 TRADD_N IPR036729 TRADD_N_sf
PANTHERⁱ	PTHR14913 PTHR14913, 1 hit
Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF09034 TRADD_N, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD182470 TRADD_N, 1 hit
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit SSF55044 SSF55044, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRADD_HUMAN
Accessionⁱ	Q15628Primary (citable) accession number: Q15628 Secondary accession number(s): B2RDS3, B3KQZ9, Q52NZ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 15, 1999
	Last modified:	October 10, 2018
	This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15628 (TRADD_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Tumor necrosis factor receptor type 1-associated DEATH domain protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ