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Protein

Olfactory receptor 8B8

Gene

OR8B8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor (Potential). May be involved in taste perception.Curated

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of smell Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8B8
Alternative name(s):
Olfactory receptor TPCR85
Olfactory-like receptor JCG8
Gene namesi
Name:OR8B8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000197125.2
HGNCiHGNC:8477 OR8B8
neXtProtiNX_Q15620

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 311CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197125
PharmGKBiPA32756

Polymorphism and mutation databases

BioMutaiOR8B8
DMDMi14423794

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506571 – 311Olfactory receptor 8B8Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15620
PeptideAtlasiQ15620
PRIDEiQ15620
ProteomicsDBi60660

Expressioni

Tissue specificityi

Expressed in the tongue and testis.

Gene expression databases

BgeeiENSG00000197125
CleanExiHS_OR8B8
ExpressionAtlasiQ15620 baseline and differential
GenevisibleiQ15620 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330280

Structurei

3D structure databases

ProteinModelPortaliQ15620
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV7V Eukaryota
ENOG41115S0 LUCA
GeneTreeiENSGT00900000140862
HOVERGENiHBG017625
InParanoidiQ15620
KOiK04257
OMAiVTFCANN
OrthoDBiEOG091G0AZH
PhylomeDBiQ15620
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q15620-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAENSSFVT QFILAGLTDQ PGVQIPLFFL FLGFYVVTVV GNLGLITLIR
60 70 80 90 100
LNSHLHTPMY FFLYNLSFID FCYSSVITPK MLMSFVLKKN SISYAGCMTQ
110 120 130 140 150
LFFFLFFVVS ESFILSAMAY DRYVAICNPL LYMVTMSPQV CFLLLLGVYG
160 170 180 190 200
MGFAGAMAHT ACMMGVTFCA NNLVNHYMCD ILPLLECACT STYVNELVVF
210 220 230 240 250
VVVGIDIGVP TVTIFISYAL ILSSIFHIDS TEGRSKAFST CSSHIIAVSL
260 270 280 290 300
FFGSGAFMYL KPFSLLAMNQ GKVSSLFYTT VVPMLNPLIY SLRNKDVKVA
310
LKKILNKNAF S
Length:311
Mass (Da):34,482
Last modified:June 20, 2001 - v2
Checksum:i9D8AAC4DA179ABE6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204G → S in CAA61822 (PubMed:9119360).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238488 mRNA Translation: AAL32997.1
AB065832 Genomic DNA Translation: BAC06051.1
CH471065 Genomic DNA Translation: EAW67583.1
BC130393 mRNA Translation: AAI30394.1
BC130419 mRNA Translation: AAI30420.1
AF399510 Genomic DNA Translation: AAK94995.1
X89675 mRNA Translation: CAA61822.1
CCDSiCCDS8446.1
PIRiS58007
RefSeqiNP_036510.1, NM_012378.1
UniGeneiHs.351822

Genome annotation databases

EnsembliENST00000328064; ENSP00000330280; ENSG00000197125
ENST00000642064; ENSP00000493014; ENSG00000197125
GeneIDi26493
KEGGihsa:26493
UCSCiuc010sal.3 human

Similar proteinsi

Entry informationi

Entry nameiOR8B8_HUMAN
AccessioniPrimary (citable) accession number: Q15620
Secondary accession number(s): A1L446, Q96RC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: June 20, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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