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Entry version 126 (16 Oct 2019)
Sequence version 2 (15 May 2007)
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Protein

Dixin

Gene

DIXDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processWnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dixin
Alternative name(s):
Coiled-coil protein DIX1
Short name:
Coiled-coil-DIX1
DIX domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DIXDC1
Synonyms:CCD1, KIAA1735
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23695 DIXDC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610493 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q155Q3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi648D → A: Loss of interaction with DVL2. Abolishes activation of Wnt signaling. 1 Publication1
Mutagenesisi651F → A: Loss of interaction with DVL2. Abolishes activation of Wnt signaling. 1 Publication1
Mutagenesisi655K → A: Loss of interaction with DVL2. Abolishes activation of Wnt signaling. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
85458

Open Targets

More...
OpenTargetsi
ENSG00000150764

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134988674

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q155Q3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DIXDC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147641721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002872231 – 683DixinAdd BLAST683
Isoform 2 (identifier: Q155Q3-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei186PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei590PhosphoserineCombined sources1
Isoform 2 (identifier: Q155Q3-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine and serine residues.1 Publication
Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q155Q3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q155Q3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q155Q3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q155Q3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q155Q3

PeptideAtlas

More...
PeptideAtlasi
Q155Q3

PRoteomics IDEntifications database

More...
PRIDEi
Q155Q3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
23427
60652 [Q155Q3-1]
60653 [Q155Q3-2]
60654 [Q155Q3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q155Q3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q155Q3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with higher expression in cardiac and skeletal muscles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150764 Expressed in 235 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q155Q3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q155Q3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039658

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 but not isoform 2 binds filamentous actin.

Interacts with the complex composed of DVL2 and Rac.

Interacts with AXIN1; competes with MAP3K1.

Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1. Directly interacts (via DIX domain) with DVL2 (via DIX domain).

Interacts with gamma-tubulin.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124542, 23 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q155Q3

Protein interaction database and analysis system

More...
IntActi
Q155Q3, 23 interactors

Molecular INTeraction database

More...
MINTi
Q155Q3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000394352

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1683
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q155Q3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 127Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST108
Domaini600 – 680DIXPROSITE-ProRule annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni127 – 300Actin-bindingAdd BLAST174

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili279 – 452Sequence analysisAdd BLAST174

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4.1 Publication
The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DIXDC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFNC Eukaryota
ENOG410XPPR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182903

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q155Q3

Identification of Orthologs from Complete Genome Data

More...
OMAi
TSACTKV

Database of Orthologous Groups

More...
OrthoDBi
949210at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q155Q3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit
3.10.20.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR10878 PTHR10878, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF00778 DIX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00021 DAX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS50841 DIX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q155Q3-1) [UniParc]FASTAAdd to basket
Also known as: l-DIXDC1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLACLTRGNL LDVLQEGFNE QQLQAYVAWV NAQLKKRPAV KPVQDLRQDL
60 70 80 90 100
RDGVILAYLI EIVAGEKLSG VQLSPGNQQE MKNNVEKVLQ FVASKKIRMH
110 120 130 140 150
QTSAKDIVDG NLKSIMRLVL ALAAHFKPGS SRTVNQGRDS RAPLQSHRPH
160 170 180 190 200
CATAVAQGAA AALADVCHDM SRSGRDVFRY RQRNSSMDEE IENPYWSVRA
210 220 230 240 250
LVQQYEGQQR SPSESSCSSL TSPSPIHSAK SESIITQSEE KADFVIIPAE
260 270 280 290 300
GIENRTEGTD SPLSRDWRPG SPGTYLETSW EEQLLEQQEY LEKEMEEAKK
310 320 330 340 350
MISGLQALLL NGSLPEDEQE RPLALCEPGV NPEEQLIIIQ SRLDQSMEEN
360 370 380 390 400
QDLKKELLKC KQEARNLQGI KDALQQRLTQ QDTSVLQLKQ ELLRANMDKD
410 420 430 440 450
ELHNQNVDLQ RKLDERNRLL GEYKKELGQK DRLLQQHQAK LEEALRKLSD
460 470 480 490 500
VSYHQVDLER ELEHKDVLLA HCMKREADEA TNYNSHNSQS NGFLLPTAGK
510 520 530 540 550
GATSVSNRGT SDLQLVRDAL RSLRNSFSGH DPQHHTIDSL EQGISSLMER
560 570 580 590 600
LHVMETQKKQ ERKVRVKSPR TQVGSEYRES WPPNSKLPHS QSSPTVSSTC
610 620 630 640 650
TKVLYFTDRS LTPFMVNIPK RLEEVTLKDF KAAIDREGNH RYHFKALDPE
660 670 680
FGTVKEEIFH DDDAIPGWEG KIVAWVEEDH GEN
Note: Major isoform. Ubiquitously expressed.
Length:683
Mass (Da):77,478
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE643D1A69B00238C
GO
Isoform 2 (identifier: Q155Q3-2) [UniParc]FASTAAdd to basket
Also known as: s-DIXDC1

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: Missing.
     212-219: PSESSCSS → MGGTQVKC

Note: Major isoform. Preferentially expressed in cardiac and skeletal muscles.
Show »
Length:472
Mass (Da):53,942
Checksum:i70C4312A59CAAF47
GO
Isoform 3 (identifier: Q155Q3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-219: S → R
     220-683: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):24,428
Checksum:iF27E0386517E1EAB
GO
Isoform 4 (identifier: Q155Q3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRFNNSLLPTEPS
     219-219: S → R
     220-683: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):24,313
Checksum:i7EC65502524E280C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVH1A0A087WVH1_HUMAN
Dixin
DIXDC1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH35509 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64479 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB21826 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB71039 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140S → P in ABG25914 (PubMed:16814745).Curated1
Sequence conflicti144L → R in ABG25914 (PubMed:16814745).Curated1
Sequence conflicti168H → Q in ABG25914 (PubMed:16814745).Curated1
Sequence conflicti378L → S in BAB71039 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032294300K → R. Corresponds to variant dbSNP:rs34575249Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0253781 – 211Missing in isoform 2. 2 PublicationsAdd BLAST211
Alternative sequenceiVSP_0545651 – 20MLACL…EGFNE → MGTQVVMRFNNSLLPTEPS in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_025379212 – 219PSESSCSS → MGGTQVKC in isoform 2. 2 Publications8
Alternative sequenceiVSP_025380219S → R in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_025381220 – 683Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST464

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ642016 mRNA Translation: ABG25914.1
AB051522 mRNA Translation: BAB21826.1 Different initiation.
AP000907 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67171.1
BC033034 mRNA Translation: AAH33034.1
BC035509 mRNA Translation: AAH35509.1 Sequence problems.
BC041626 mRNA Translation: AAH41626.2
BC048294 mRNA Translation: AAH48294.1
BC064479 mRNA Translation: AAH64479.1 Sequence problems.
BC128600 mRNA Translation: AAI28601.1
AK055899 mRNA Translation: BAB71039.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS60957.1 [Q155Q3-5]
CCDS73381.1 [Q155Q3-1]
CCDS73382.1 [Q155Q3-2]

NCBI Reference Sequences

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RefSeqi
NP_001033043.1, NM_001037954.3 [Q155Q3-1]
NP_001265471.1, NM_001278542.1 [Q155Q3-5]
NP_219493.1, NM_033425.4 [Q155Q3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000440460; ENSP00000394352; ENSG00000150764 [Q155Q3-1]
ENST00000529225; ENSP00000434130; ENSG00000150764 [Q155Q3-5]
ENST00000615255; ENSP00000480808; ENSG00000150764 [Q155Q3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
85458

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:85458

UCSC genome browser

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UCSCi
uc001pmj.4 human [Q155Q3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ642016 mRNA Translation: ABG25914.1
AB051522 mRNA Translation: BAB21826.1 Different initiation.
AP000907 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67171.1
BC033034 mRNA Translation: AAH33034.1
BC035509 mRNA Translation: AAH35509.1 Sequence problems.
BC041626 mRNA Translation: AAH41626.2
BC048294 mRNA Translation: AAH48294.1
BC064479 mRNA Translation: AAH64479.1 Sequence problems.
BC128600 mRNA Translation: AAI28601.1
AK055899 mRNA Translation: BAB71039.1 Sequence problems.
CCDSiCCDS60957.1 [Q155Q3-5]
CCDS73381.1 [Q155Q3-1]
CCDS73382.1 [Q155Q3-2]
RefSeqiNP_001033043.1, NM_001037954.3 [Q155Q3-1]
NP_001265471.1, NM_001278542.1 [Q155Q3-5]
NP_219493.1, NM_033425.4 [Q155Q3-2]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PZ7X-ray2.44A597-683[»]
SMRiQ155Q3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi124542, 23 interactors
CORUMiQ155Q3
IntActiQ155Q3, 23 interactors
MINTiQ155Q3
STRINGi9606.ENSP00000394352

PTM databases

iPTMnetiQ155Q3
PhosphoSitePlusiQ155Q3

Polymorphism and mutation databases

BioMutaiDIXDC1
DMDMi147641721

Proteomic databases

EPDiQ155Q3
jPOSTiQ155Q3
MassIVEiQ155Q3
MaxQBiQ155Q3
PaxDbiQ155Q3
PeptideAtlasiQ155Q3
PRIDEiQ155Q3
ProteomicsDBi23427
60652 [Q155Q3-1]
60653 [Q155Q3-2]
60654 [Q155Q3-4]

Genome annotation databases

EnsembliENST00000440460; ENSP00000394352; ENSG00000150764 [Q155Q3-1]
ENST00000529225; ENSP00000434130; ENSG00000150764 [Q155Q3-5]
ENST00000615255; ENSP00000480808; ENSG00000150764 [Q155Q3-2]
GeneIDi85458
KEGGihsa:85458
UCSCiuc001pmj.4 human [Q155Q3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
85458
DisGeNETi85458

GeneCards: human genes, protein and diseases

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GeneCardsi
DIXDC1
HGNCiHGNC:23695 DIXDC1
HPAiHPA039658
MIMi610493 gene
neXtProtiNX_Q155Q3
OpenTargetsiENSG00000150764
PharmGKBiPA134988674

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFNC Eukaryota
ENOG410XPPR LUCA
GeneTreeiENSGT00950000182903
InParanoidiQ155Q3
OMAiTSACTKV
OrthoDBi949210at2759
PhylomeDBiQ155Q3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DIXDC1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DIXDC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
85458
PharosiQ155Q3

Protein Ontology

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PROi
PR:Q155Q3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000150764 Expressed in 235 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ155Q3 baseline and differential
GenevisibleiQ155Q3 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10878 PTHR10878, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00778 DIX, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00021 DAX, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS50841 DIX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIXC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q155Q3
Secondary accession number(s): A1A5D8
, E9PRV4, Q6P2J8, Q6PIK4, Q86SR7, Q8IVY4, Q96N69, Q9C0C8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: October 16, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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