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Entry version 196 (07 Oct 2020)
Sequence version 2 (16 Feb 2004)
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Protein

Na(+)/H(+) exchange regulatory cofactor NHE-RF2

Gene

SLC9A3R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q15599

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.24.1.2, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Short name:
NHERF-2
Alternative name(s):
NHE3 kinase A regulatory protein E3KARP
SRY-interacting protein 1
Short name:
SIP-1
Sodium-hydrogen exchanger regulatory factor 2
Solute carrier family 9 isoform A3 regulatory factor 2
Tyrosine kinase activator protein 1
Short name:
TKA-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC9A3R2
Synonyms:NHERF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000065054.13

Human Gene Nomenclature Database

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HGNCi
HGNC:11076, SLC9A3R2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606553, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15599

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9351

Open Targets

More...
OpenTargetsi
ENSG00000065054

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35932

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15599, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC9A3R2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
42559433

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000968051 – 337Na(+)/H(+) exchange regulatory cofactor NHE-RF2Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei130PhosphoserineBy similarity1
Modified residuei183PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei269PhosphoserineBy similarity1
Modified residuei280PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15599

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15599

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15599

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15599

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15599

PeptideAtlas

More...
PeptideAtlasi
Q15599

PRoteomics IDEntifications database

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PRIDEi
Q15599

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
12763
42464
60650 [Q15599-1]
60651 [Q15599-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15599

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15599

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000065054, Expressed in right lung and 149 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15599, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15599, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000065054, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, and heterodimer with SLC9A3R1. Binds PDZK1.

Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity).

Interacts (via the PDZ domains) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is detected in glomerular epithelium cells (By similarity). Binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX and LPAR2.

Interacts with MCC and PODXL.

Interacts with SGK1 and KCNJ1/ROMK1.

Interacts (via the PDZ domains) with SLC26A6 isoform 4 and isoform 5.

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114754, 137 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q15599

Database of interacting proteins

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DIPi
DIP-29093N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q15599

Protein interaction database and analysis system

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IntActi
Q15599, 56 interactors

Molecular INTeraction database

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MINTi
Q15599

STRING: functional protein association networks

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STRINGi
9606.ENSP00000408005

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q15599, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15599

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15599

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 90PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini150 – 230PDZ 2PROSITE-ProRule annotationAdd BLAST81

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3528, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000182849

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_038627_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15599

KEGG Orthology (KO)

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KOi
K13358

Identification of Orthologs from Complete Genome Data

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OMAi
LKPRLCH

Database of Orthologous Groups

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OrthoDBi
1149281at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15599

TreeFam database of animal gene trees

More...
TreeFami
TF350449

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.42.10, 2 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00212

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015098, EBP50_C-term
IPR017300, NHERF-1/NHERF-2
IPR031197, NHERF-2
IPR001478, PDZ
IPR036034, PDZ_sf

The PANTHER Classification System

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PANTHERi
PTHR14191:SF4, PTHR14191:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF09007, EBP50_C, 1 hit
PF00595, PDZ, 2 hits

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037866, EBP50, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00228, PDZ, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15599-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPEPLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL
60 70 80 90 100
RAGDRLVEVN GVNVEGETHH QVVQRIKAVE GQTRLLVVDQ ETDEELRRRQ
110 120 130 140 150
LTCTEEMAQR GLPPAHDPWE PKPDWAHTGS HSSEAGKKDV SGPLRELRPR
160 170 180 190 200
LCHLRKGPQG YGFNLHSDKS RPGQYIRSVD PGSPAARSGL RAQDRLIEVN
210 220 230 240 250
GQNVEGLRHA EVVASIKARE DEARLLVVDP ETDEHFKRLR VTPTEEHVEG
260 270 280 290 300
PLPSPVTNGT SPAQLNGGSA CSSRSDLPGS DKDTEDGSAW KQDPFQESGL
310 320 330
HLSPTAAEAK EKARAMRVNK RAPQMDWNRK REIFSNF
Length:337
Mass (Da):37,414
Last modified:February 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F5D341590D22ED7
GO
Isoform 2 (identifier: Q15599-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-296: Missing.

Show »
Length:326
Mass (Da):36,153
Checksum:i59EB725D61D896DC
GO
Isoform 3 (identifier: Q15599-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MAAPEPLRPRLCRLVRGEQGYGFHLHG → MARSGSATPPARAPGAPPRSPPQRLVQ
     28-138: Missing.

Show »
Length:226
Mass (Da):24,718
Checksum:i51D77F534CB2328A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQS0H3BQS0_HUMAN
Na(+)/H(+) exchange regulatory cofa...
SLC9A3R2
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN50H3BN50_HUMAN
Na(+)/H(+) exchange regulatory cofa...
SLC9A3R2
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUQ9H3BUQ9_HUMAN
Na(+)/H(+) exchange regulatory cofa...
SLC9A3R2
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMF5H3BMF5_HUMAN
Na(+)/H(+) exchange regulatory cofa...
SLC9A3R2
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH14513 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA90511 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51Missing in CAA90511 (PubMed:9314537).Curated1
Sequence conflicti180D → Y in BM920873 (PubMed:15489334).Curated1
Sequence conflicti334 – 336FSN → LQH in BM920873 (PubMed:15489334).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468491 – 27MAAPE…FHLHG → MARSGSATPPARAPGAPPRS PPQRLVQ in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_04685028 – 138Missing in isoform 3. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_009378286 – 296Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U82108 mRNA Translation: AAB53042.1
Z50150 mRNA Translation: CAA90511.1 Frameshift.
AF004900 mRNA Translation: AAC63061.1
AF035771 mRNA Translation: AAC52090.1
AB014460 Genomic DNA Translation: BAA32696.1
AB016243 Genomic DNA Translation: BAA33216.1
AC005600 Genomic DNA Translation: AAC34208.1
AC093513 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85563.1
CH471112 Genomic DNA Translation: EAW85564.1
CH471112 Genomic DNA Translation: EAW85565.1
CH471112 Genomic DNA Translation: EAW85566.1
BC014513 mRNA Translation: AAH14513.2 Different initiation.
BC106001 mRNA Translation: AAI06002.1
BM920873 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS45382.1 [Q15599-1]
CCDS45383.1 [Q15599-2]
CCDS58407.1 [Q15599-3]

Protein sequence database of the Protein Information Resource

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PIRi
G01158

NCBI Reference Sequences

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RefSeqi
NP_001123484.1, NM_001130012.2 [Q15599-1]
NP_001239002.1, NM_001252073.1 [Q15599-3]
NP_004776.3, NM_004785.5 [Q15599-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000424542; ENSP00000408005; ENSG00000065054 [Q15599-1]
ENST00000432365; ENSP00000402857; ENSG00000065054 [Q15599-2]
ENST00000566198; ENSP00000456895; ENSG00000065054 [Q15599-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9351

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9351

UCSC genome browser

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UCSCi
uc002coi.3, human [Q15599-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82108 mRNA Translation: AAB53042.1
Z50150 mRNA Translation: CAA90511.1 Frameshift.
AF004900 mRNA Translation: AAC63061.1
AF035771 mRNA Translation: AAC52090.1
AB014460 Genomic DNA Translation: BAA32696.1
AB016243 Genomic DNA Translation: BAA33216.1
AC005600 Genomic DNA Translation: AAC34208.1
AC093513 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85563.1
CH471112 Genomic DNA Translation: EAW85564.1
CH471112 Genomic DNA Translation: EAW85565.1
CH471112 Genomic DNA Translation: EAW85566.1
BC014513 mRNA Translation: AAH14513.2 Different initiation.
BC106001 mRNA Translation: AAI06002.1
BM920873 mRNA No translation available.
CCDSiCCDS45382.1 [Q15599-1]
CCDS45383.1 [Q15599-2]
CCDS58407.1 [Q15599-3]
PIRiG01158
RefSeqiNP_001123484.1, NM_001130012.2 [Q15599-1]
NP_001239002.1, NM_001252073.1 [Q15599-3]
NP_004776.3, NM_004785.5 [Q15599-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D11X-ray2.81E/F/G/H310-337[»]
2HE4X-ray1.45A147-228[»]
2OCSX-ray1.50A9-91[»]
4P0CX-ray1.34A9-90[»]
SMRiQ15599
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114754, 137 interactors
CORUMiQ15599
DIPiDIP-29093N
ELMiQ15599
IntActiQ15599, 56 interactors
MINTiQ15599
STRINGi9606.ENSP00000408005

Protein family/group databases

TCDBi8.A.24.1.2, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

PTM databases

iPTMnetiQ15599
PhosphoSitePlusiQ15599

Polymorphism and mutation databases

BioMutaiSLC9A3R2
DMDMi42559433

Proteomic databases

EPDiQ15599
jPOSTiQ15599
MassIVEiQ15599
MaxQBiQ15599
PaxDbiQ15599
PeptideAtlasiQ15599
PRIDEiQ15599
ProteomicsDBi12763
42464
60650 [Q15599-1]
60651 [Q15599-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
943, 245 antibodies

Genome annotation databases

EnsembliENST00000424542; ENSP00000408005; ENSG00000065054 [Q15599-1]
ENST00000432365; ENSP00000402857; ENSG00000065054 [Q15599-2]
ENST00000566198; ENSP00000456895; ENSG00000065054 [Q15599-3]
GeneIDi9351
KEGGihsa:9351
UCSCiuc002coi.3, human [Q15599-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9351
DisGeNETi9351
EuPathDBiHostDB:ENSG00000065054.13

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC9A3R2
HGNCiHGNC:11076, SLC9A3R2
HPAiENSG00000065054, Low tissue specificity
MIMi606553, gene
neXtProtiNX_Q15599
OpenTargetsiENSG00000065054
PharmGKBiPA35932

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3528, Eukaryota
GeneTreeiENSGT00950000182849
HOGENOMiCLU_038627_1_0_1
InParanoidiQ15599
KOiK13358
OMAiLKPRLCH
OrthoDBi1149281at2759
PhylomeDBiQ15599
TreeFamiTF350449

Enzyme and pathway databases

PathwayCommonsiQ15599

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9351, 3 hits in 882 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC9A3R2, human
EvolutionaryTraceiQ15599

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9351
PharosiQ15599, Tbio

Protein Ontology

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PROi
PR:Q15599
RNActiQ15599, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000065054, Expressed in right lung and 149 other tissues
ExpressionAtlasiQ15599, baseline and differential
GenevisibleiQ15599, HS

Family and domain databases

Gene3Di2.30.42.10, 2 hits
IDEALiIID00212
InterProiView protein in InterPro
IPR015098, EBP50_C-term
IPR017300, NHERF-1/NHERF-2
IPR031197, NHERF-2
IPR001478, PDZ
IPR036034, PDZ_sf
PANTHERiPTHR14191:SF4, PTHR14191:SF4, 1 hit
PfamiView protein in Pfam
PF09007, EBP50_C, 1 hit
PF00595, PDZ, 2 hits
PIRSFiPIRSF037866, EBP50, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 2 hits
SUPFAMiSSF50156, SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNHRF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15599
Secondary accession number(s): D3DU84
, D3DU85, H3BSV6, O00272, O00556, Q3KQY7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: October 7, 2020
This is version 196 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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