Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear receptor coactivator 2

Gene

NCOA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-159418 Recycling of bile acids and salts
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-1989781 PPARA activates gene expression
R-HSA-211976 Endogenous sterols
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-3214847 HATs acetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-9018519 Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q15596

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q15596

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivator 2
Short name:
NCoA-2
Alternative name(s):
Class E basic helix-loop-helix protein 75
Short name:
bHLHe75
Transcriptional intermediary factor 2
Short name:
hTIF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCOA2
Synonyms:BHLHE75, SRC2, TIF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000140396.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7669 NCOA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601993 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15596

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi644 – 645LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 693-A-A-694 and 748-A-A-749. 1 Publication2
Mutagenesisi693 – 694LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 644-A-A-665 and 748-A-A-749. 1 Publication2
Mutagenesisi748 – 749LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 644-A-A-665 and 693-A-A-694. 1 Publication2
Mutagenesisi1079 – 1083LLDQL → AADQA: Reduces transcriptional coactivation and disrupts interaction with CREBBP/CBP. 1 Publication5
Mutagenesisi1081 – 1082DQ → AA: Has little effect on transcriptional coactivation. 1 Publication2

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei869 – 870Breakpoint for translocation to form KAT6A-NCOA23 Publications2

Organism-specific databases

DisGeNET

More...
DisGeNETi
10499

Open Targets

More...
OpenTargetsi
ENSG00000140396

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31471

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB06871 17-METHYL-17-ALPHA-DIHYDROEQUILENIN
DB07863 2-chloro-5-nitro-N-phenylbenzamide
DB07708 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
DB07712 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
DB01645 Genistein
DB02998 Methyltrienolone
DB08773 RALOXIFENE CORE
DB08601 tributylstannanyl

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCOA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13626594

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000944022 – 1464Nuclear receptor coactivator 2Add BLAST1463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei338Asymmetric dimethylarginineBy similarity1
Modified residuei487PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1
Modified residuei636N6-acetyllysineBy similarity1
Modified residuei640N6-acetyllysineCombined sources1
Cross-linki648Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei682PhosphoserineCombined sources1
Modified residuei699PhosphoserineCombined sources1
Cross-linki705Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei736PhosphoserineCombined sources1
Modified residuei771PhosphoserineCombined sources1
Modified residuei780N6-acetyllysineCombined sources1
Modified residuei785N6-acetyllysine; alternateCombined sources1
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei864Asymmetric dimethylarginineBy similarity1
Modified residuei874Asymmetric dimethylarginineBy similarity1
Modified residuei1173Asymmetric dimethylarginineCombined sources1
Modified residuei1177Asymmetric dimethylarginineCombined sources1
Modified residuei1190Asymmetric dimethylarginineCombined sources1
Modified residuei1196Asymmetric dimethylarginineCombined sources1
Modified residuei1203Asymmetric dimethylarginineCombined sources1
Modified residuei1221Asymmetric dimethylarginineCombined sources1
Modified residuei1240Asymmetric dimethylarginineBy similarity1
Modified residuei1261Omega-N-methylarginineCombined sources1
Modified residuei1266Asymmetric dimethylarginineCombined sources1
Cross-linki1454Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15596

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15596

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15596

PeptideAtlas

More...
PeptideAtlasi
Q15596

PRoteomics IDEntifications database

More...
PRIDEi
Q15596

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60649

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15596

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15596

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140396 Expressed in 237 organ(s), highest expression level in epithelium of mammary gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_NCOA2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15596 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15596 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060243

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 and DDX5. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif). Interacts with RWDD3. Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Interacts with NR4A3; potentiates the activity of the NR4A3 (By similarity). Interacts with NR1H3 (PubMed:19481530).By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115761, 77 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-702 PPARgamma-NCOA2 activated nuclear receptor complex
CPX-816 RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q15596

Database of interacting proteins

More...
DIPi
DIP-5997N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q15596

Protein interaction database and analysis system

More...
IntActi
Q15596, 27 interactors

Molecular INTeraction database

More...
MINTi
Q15596

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000399968

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q15596

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11464
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15596

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15596

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15596

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 83bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini119 – 183PASPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni691 – 743CASP8AP2-bindingBy similarityAdd BLAST53
Regioni730 – 1121Interaction with ARNTLBy similarityAdd BLAST392

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi641 – 645LXXLL motif 15
Motifi690 – 694LXXLL motif 25
Motifi745 – 749LXXLL motif 35
Motifi878 – 882LXXLL motif 45
Motifi1079 – 1087LLXXLXXXL motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1254 – 1260Poly-Gln7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.1 Publication
The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.1 Publication
Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ5S Eukaryota
ENOG410XPF9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063109

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230947

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052583

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15596

KEGG Orthology (KO)

More...
KOi
K11255

Identification of Orthologs from Complete Genome Data

More...
OMAi
VNMNPPQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00US

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15596

TreeFam database of animal gene trees

More...
TreeFami
TF332652

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit
cd00130 PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.1070, 1 hit
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028822 NCOA2
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL

The PANTHER Classification System

More...
PANTHERi
PTHR10684 PTHR10684, 1 hit
PTHR10684:SF2 PTHR10684:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038181 Nuclear_receptor_coactivator, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q15596-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRNTEKRNRE QENKYIEELA
60 70 80 90 100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS
110 120 130 140 150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGNVVFVS ENVTQYLRYN
160 170 180 190 200
QEELMNKSVY SILHVGDHTE FVKNLLPKSI VNGGSWSGEP PRRNSHTFNC
210 220 230 240 250
RMLVKPLPDS EEEGHDNQEA HQKYETMQCF AVSQPKSIKE EGEDLQSCLI
260 270 280 290 300
CVARRVPMKE RPVLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV
310 320 330 340 350
RRCIQKFHAQ HEGESVSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ
360 370 380 390 400
TKSKLIRSQT TNEPQLVISL HMLHREQNVC VMNPDLTGQT MGKPLNPISS
410 420 430 440 450
NSPAHQALCS GNPGQDMTLS SNINFPINGP KEQMGMPMGR FGGSGGMNHV
460 470 480 490 500
SGMQATTPQG SNYALKMNSP SQSSPGMNPG QPTSMLSPRH RMSPGVAGSP
510 520 530 540 550
RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGS
560 570 580 590 600
SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA
610 620 630 640 650
ESSCHPGEQK ETNDPNLPPA VSSERADGQS RLHDSKGQTK LLQLLTTKSD
660 670 680 690 700
QMEPSPLASS LSDTNKDSTG SLPGSGSTHG TSLKEKHKIL HRLLQDSSSP
710 720 730 740 750
VDLAKLTAEA TGKDLSQESS STAPGSEVTI KQEPVSPKKK ENALLRYLLD
760 770 780 790 800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTEKEE MSFEPGDQPG
810 820 830 840 850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP AGSVDKQAII NDLMQLTAEN
860 870 880 890 900
SPVTPVGAQK TALRISQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG
910 920 930 940 950
PFPPIRNSSP YSVIPQPGMM GNQGMIGNQG NLGNSSTGMI GNSASRPTMP
960 970 980 990 1000
SGEWAPQSSA VRVTCAATTS AMNRPVQGGM IRNPAASIPM RPSSQPGQRQ
1010 1020 1030 1040 1050
TLQSQVMNIG PSELEMNMGG PQYSQQQAPP NQTAPWPESI LPIDQASFAS
1060 1070 1080 1090 1100
QNRQPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL
1110 1120 1130 1140 1150
GIPELVSQSQ AVDPEQFSSQ DSNIMLEQKA PVFPQQYASQ AQMAQGSYSP
1160 1170 1180 1190 1200
MQDPNFHTMG QRPSYATLRM QPRPGLRPTG LVQNQPNQLR LQLQHRLQAQ
1210 1220 1230 1240 1250
QNRQPLMNQI SNVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR
1260 1270 1280 1290 1300
QMHQQQQVQQ RTLMMRGQGL NMTPSMVAPS GMPATMSNPR IPQANAQQFP
1310 1320 1330 1340 1350
FPPNYGISQQ PDPGFTGATT PQSPLMSPRM AHTQSPMMQQ SQANPAYQAP
1360 1370 1380 1390 1400
SDINGWAQGN MGGNSMFSQQ SPPHFGQQAN TSMYSNNMNI NVSMATNTGG
1410 1420 1430 1440 1450
MSSMNQMTGQ ISMTSVTSVP TSGLSSMGPE QVNDPALRGG NLFPNQLPGM
1460
DMIKQEGDTT RKYC
Length:1,464
Mass (Da):159,157
Last modified:May 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A61AA5D1878304B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWM1E7EWM1_HUMAN
Nuclear receptor coactivator 2
NCOA2
946Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBB6H0YBB6_HUMAN
Nuclear receptor coactivator 2
NCOA2
590Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFN9E5RFN9_HUMAN
Nuclear receptor coactivator 2
NCOA2
16Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMT0A0A1D5RMT0_HUMAN
Nuclear receptor coactivator 2
NCOA2
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0245461282M → I1 PublicationCorresponds to variant dbSNP:rs2228591Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X97674 mRNA Translation: CAA66263.1
BC114383 mRNA Translation: AAI14384.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47872.1

NCBI Reference Sequences

More...
RefSeqi
NP_001308632.1, NM_001321703.1
NP_001308636.1, NM_001321707.1
NP_001308640.1, NM_001321711.1
NP_001308641.1, NM_001321712.1
NP_001308642.1, NM_001321713.1
NP_006531.1, NM_006540.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.446678
Hs.595378

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000452400; ENSP00000399968; ENSG00000140396

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10499

UCSC genome browser

More...
UCSCi
uc003xyn.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97674 mRNA Translation: CAA66263.1
BC114383 mRNA Translation: AAI14384.1
CCDSiCCDS47872.1
RefSeqiNP_001308632.1, NM_001321703.1
NP_001308636.1, NM_001321707.1
NP_001308640.1, NM_001321711.1
NP_001308641.1, NM_001321712.1
NP_001308642.1, NM_001321713.1
NP_006531.1, NM_006540.3
UniGeneiHs.446678
Hs.595378

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GWQX-ray2.45C/D688-696[»]
1GWRX-ray2.40C/D742-750[»]
1M2ZX-ray2.50B/E734-754[»]
1MV9X-ray1.90B686-698[»]
1MVCX-ray1.90B686-698[»]
1MZNX-ray1.90B/D/F/H686-698[»]
1P93X-ray2.70E/F/G/H740-751[»]
1T63X-ray2.07B740-753[»]
1T65X-ray1.66B686-698[»]
1UHLX-ray2.90C/D687-696[»]
1YOKX-ray2.50B/C740-753[»]
1ZDTX-ray2.10P/Q741-752[»]
1ZDUX-ray2.50P/Q741-751[»]
1ZKYX-ray2.25C/D686-698[»]
2AO6X-ray1.89B740-753[»]
2B1VX-ray1.80C/D686-698[»]
2B1ZX-ray1.78C/D686-698[»]
2B23X-ray2.10C/D686-698[»]
2FAIX-ray2.10C/D686-698[»]
2G44X-ray2.65C/D686-698[»]
2G5OX-ray2.30C/D686-698[»]
2LDCNMR-A687-697[»]
2P15X-ray1.94C/D686-698[»]
2P1TX-ray1.80B686-698[»]
2P1UX-ray2.20B686-698[»]
2P1VX-ray2.20B686-698[»]
2Q7JX-ray1.90B740-753[»]
2Q7LX-ray1.92B740-753[»]
2YJDX-ray1.93C/D687-697[»]
2ZXZX-ray3.00B686-698[»]
2ZY0X-ray2.90B/D686-698[»]
3A9EX-ray2.75I686-698[»]
3CLDX-ray2.84C/H740-751[»]
3DZUX-ray3.20E/G685-697[»]
3DZYX-ray3.10E/G685-697[»]
3E00X-ray3.10E/G685-697[»]
3E7CX-ray2.15D/H741-751[»]
3E94X-ray1.90B686-698[»]
3ERDX-ray2.03C/D686-698[»]
3FUGX-ray2.00B686-698[»]
3GN8X-ray2.50C/E734-754[»]
3K22X-ray2.10D/H740-751[»]
3K23X-ray3.00D/E/F740-751[»]
3KWYX-ray2.30B686-698[»]
3KYTX-ray2.35C686-697[»]
3L0EX-ray2.30B740-751[»]
3L0JX-ray2.40C688-697[»]
3L0LX-ray1.74C/E685-697[»]
3O1DX-ray2.40B686-698[»]
3O1EX-ray2.50B686-698[»]
3OAPX-ray2.05B686-696[»]
3OZJX-ray2.10B/D686-696[»]
3PCUX-ray2.00B687-696[»]
3PLZX-ray1.75C/D740-753[»]
3Q95X-ray2.05C/D686-698[»]
3R5MX-ray2.80B/D687-696[»]
3UP0X-ray1.60P/Q740-753[»]
3UP3X-ray1.25P741-754[»]
4CSJX-ray2.30B741-753[»]
4DOSX-ray2.00B/C740-753[»]
4E2JX-ray2.50C/E741-752[»]
4FHHX-ray2.33B686-698[»]
4FHIX-ray2.40B686-698[»]
4IA1X-ray2.44B686-698[»]
4IA2X-ray2.95B686-698[»]
4IA3X-ray2.70B686-698[»]
4IA7X-ray2.70B686-698[»]
4IQRX-ray2.90I/J/K/L685-697[»]
4IU7X-ray2.29C/D687-696[»]
4IUIX-ray2.30C/D687-696[»]
4IV2X-ray2.14C/D687-696[»]
4IV4X-ray2.30C/D687-696[»]
4IVWX-ray2.06C/D687-696[»]
4IVYX-ray1.95C/D687-696[»]
4IW6X-ray1.98C/D687-696[»]
4IW8X-ray2.04C/D687-696[»]
4IWCX-ray2.24C/D687-696[»]
4IWFX-ray1.93C/D687-696[»]
4K4JX-ray2.00B686-698[»]
4K6IX-ray2.10B686-698[»]
4M8EX-ray2.40B686-696[»]
4M8HX-ray2.20B686-696[»]
4NIEX-ray2.01C/D686-697[»]
4NQAX-ray3.10C/D/J/K686-698[»]
4OC7X-ray2.50B686-698[»]
4P6WX-ray1.95B741-752[»]
4P6XX-ray2.50B/D/F/H/J/L740-753[»]
4PLDX-ray1.75B740-753[»]
4PLEX-ray1.75B/D/F/H740-753[»]
4POHX-ray2.30B686-698[»]
4POJX-ray2.00B686-698[»]
4PP3X-ray2.00B686-698[»]
4PP5X-ray2.00B686-698[»]
4PP6X-ray2.20C/D688-696[»]
4PPPX-ray2.69C/D688-696[»]
4PPSX-ray1.93C/D687-698[»]
4PXMX-ray1.90C/D686-698[»]
4Q0AX-ray1.90D687-695[»]
4Q13X-ray2.24C/D686-698[»]
4QE6X-ray1.65B740-752[»]
4QE8X-ray2.62C/D740-752[»]
4RFWX-ray2.40G686-698[»]
4RMCX-ray2.70B686-698[»]
4RMDX-ray1.90B686-698[»]
4RMEX-ray2.30B686-698[»]
4RUOX-ray2.81B686-698[»]
4UDCX-ray2.50B740-753[»]
4UDDX-ray1.80B740-753[»]
4WG0X-ray1.82A/B/C/D/E/F/G/H/I/J/K/L/M742-752[»]
4ZN7X-ray1.93C/D686-698[»]
4ZN9X-ray2.21C/D686-698[»]
4ZNHX-ray1.93C/D686-698[»]
4ZNSX-ray1.86C/D686-698[»]
4ZNTX-ray1.90C/D686-698[»]
4ZNUX-ray2.40C/D686-698[»]
4ZNVX-ray1.77C/D686-698[»]
4ZNWX-ray2.31C/D686-698[»]
4ZO1X-ray3.22A686-694[»]
4ZSHX-ray1.80B686-698[»]
5APHX-ray1.54C686-697[»]
5APJX-ray2.08C686-697[»]
5DI7X-ray2.24C/D686-699[»]
5DIDX-ray2.24C/D686-699[»]
5DIEX-ray2.24C/D686-699[»]
5DIGX-ray2.24C/D686-699[»]
5DK9X-ray2.28C/D686-699[»]
5DKBX-ray2.40C/D686-699[»]
5DKEX-ray2.60C/D686-699[»]
5DKGX-ray2.15C/D686-699[»]
5DKSX-ray2.60C/D686-699[»]
5DL4X-ray2.10C/D686-699[»]
5DLRX-ray2.26C/D686-699[»]
5DMCX-ray2.40C/D686-699[»]
5DMFX-ray2.40C/D686-699[»]
5DP0X-ray2.38C/D686-699[»]
5DRJX-ray2.07C/D686-699[»]
5DRMX-ray2.24C/D686-699[»]
5DTVX-ray2.29C/D686-699[»]
5DU5X-ray2.19C/D686-699[»]
5DUEX-ray2.09C/D686-699[»]
5DUGX-ray2.25C/D686-699[»]
5DUHX-ray2.24C/D686-699[»]
5DVSX-ray2.28C/D686-699[»]
5DVVX-ray2.50C/D686-699[»]
5DWEX-ray1.92C/D686-699[»]
5DWGX-ray2.30C/D686-699[»]
5DWIX-ray2.43C/D686-699[»]
5DWJX-ray2.00C/D686-699[»]
5DX3X-ray2.09C/D687-697[»]
5DXBX-ray2.08D/E687-697[»]
5DXEX-ray1.50C/D687-697[»]
5DXGX-ray1.86C/D687-697[»]
5DXKX-ray2.23C/D686-699[»]
5DXMX-ray2.37C/D686-699[»]
5DXPX-ray2.20C/D686-699[»]
5DXQX-ray2.40C/D686-699[»]
5DXRX-ray2.28C/D686-699[»]
5DY8X-ray2.03C/D686-699[»]
5DYBX-ray2.27C/D686-699[»]
5DYDX-ray2.48C/D686-699[»]
5DZ0X-ray2.24C/D686-699[»]
5DZ1X-ray2.20C/D686-699[»]
5DZ3X-ray2.15C/D686-699[»]
5DZHX-ray2.11C/D686-699[»]
5DZIX-ray1.90C/D686-699[»]
5E0WX-ray2.00C/D686-699[»]
5E0XX-ray2.01C/D686-699[»]
5E14X-ray2.22C/D686-699[»]
5E15X-ray2.10C/D686-699[»]
5E19X-ray2.24C/D686-699[»]
5E1CX-ray1.98C/D686-699[»]
5EC9X-ray2.30B686-696[»]
5EGVX-ray2.86C/D686-699[»]
5EHJX-ray2.50C/D686-699[»]
5EI1X-ray2.40C/D686-699[»]
5EITX-ray2.68C/D686-699[»]
5G3JX-ray2.40B740-753[»]
5G42X-ray1.72C688-697[»]
5G43X-ray2.58C686-697[»]
5G44X-ray1.84C686-697[»]
5G45X-ray2.07C688-697[»]
5G46X-ray1.76C688-697[»]
5G5WX-ray2.20B740-753[»]
5H1EX-ray2.60C740-752[»]
5HYRX-ray2.27F/G687-697[»]
5I4VX-ray2.61A/B/E/F687-699[»]
5IAWX-ray2.58C/D742-751[»]
5ICKX-ray2.47C/D742-752[»]
5KCCX-ray2.39C/D686-699[»]
5KCDX-ray1.82C/D686-699[»]
5KCEX-ray1.85C/D686-698[»]
C/D687-696[»]
5KCFX-ray2.07C/D686-699[»]
5KCTX-ray1.60C/D686-699[»]
5KCUX-ray2.03C/D686-699[»]
5KCWX-ray1.91C/D686-699[»]
5KD9X-ray1.78C/D686-699[»]
5KR9X-ray2.25C/D686-699[»]
5KRAX-ray2.40C/D/G/H686-699[»]
5KRCX-ray2.40C/D686-699[»]
5KRFX-ray2.19C/D686-699[»]
5KRHX-ray2.24C/D686-699[»]
5KRIX-ray2.25C/D686-699[»]
5KRJX-ray2.70C/D686-699[»]
5KRKX-ray2.39C/D686-699[»]
5KRLX-ray2.40C/D686-699[»]
5KRMX-ray2.24C/D686-699[»]
5KROX-ray2.10C/D686-699[»]
5L11X-ray1.85C740-753[»]
5LGAX-ray2.50B686-698[»]
5LYQX-ray2.17B686-698[»]
5MK4X-ray2.00B/D686-696[»]
5NFPX-ray2.10B740-753[»]
5NFTX-ray2.30B740-753[»]
5Q17X-ray2.10B741-752[»]
5SYZX-ray1.93C740-754[»]
5T1ZX-ray2.10C/D686-698[»]
5TLDX-ray2.38C/D686-698[»]
5TLFX-ray2.20C/D686-698[»]
5TLGX-ray2.23C/D686-698[»]
5TLLX-ray2.42C/D686-698[»]
5TLMX-ray2.50C/D686-698[»]
5TLOX-ray2.28C/D686-698[»]
5TLPX-ray2.08C/D686-698[»]
5TLTX-ray1.90C/D686-698[»]
5TLUX-ray2.22C/D686-698[»]
5TLVX-ray2.32C/D686-698[»]
5TLXX-ray2.10C/D686-698[»]
5TLYX-ray2.14C/D686-698[»]
5TM1X-ray2.23C/D686-698[»]
5TM2X-ray2.60C/D686-698[»]
5TM3X-ray2.19C/D686-698[»]
5TM4X-ray2.25C/D686-698[»]
5TM5X-ray2.24C/D686-698[»]
5TM6X-ray2.54C/D686-698[»]
5TM7X-ray2.40C/D686-698[»]
5TM8X-ray1.99C/D686-698[»]
5TM9X-ray2.50C/D686-698[»]
5TMLX-ray2.25C/D686-698[»]
5TMMX-ray2.20C/D686-698[»]
5TMOX-ray2.17C/D686-698[»]
5TMQX-ray2.24C/D686-698[»]
5TMRX-ray2.30C/D686-698[»]
5TMSX-ray2.24C/D686-698[»]
5TMTX-ray2.05C/D686-698[»]
5TMUX-ray2.43C/D686-698[»]
5TMVX-ray2.38C/D686-698[»]
5TMWX-ray2.29C/D686-698[»]
5TMZX-ray2.21C/D686-698[»]
5TN1X-ray2.06C/D686-698[»]
5TN3X-ray2.54C/D686-698[»]
5TN4X-ray1.86C/D686-698[»]
5TN5X-ray1.89C/D686-698[»]
5TN6X-ray2.09C/D686-698[»]
5TN7X-ray2.24C/D686-698[»]
5TN8X-ray2.65C/D686-698[»]
5U2DX-ray1.86C/D686-698[»]
5UANX-ray3.51C/D687-696[»]
5VB3X-ray1.95A685-697[»]
5VB5X-ray2.23A685-697[»]
5VB6X-ray2.04A685-697[»]
5VB7X-ray2.33A685-697[»]
5VQKX-ray3.10A685-697[»]
5VQLX-ray2.70A685-697[»]
5WGQX-ray2.30E/F687-697[»]
5WZXX-ray2.95C/D741-752[»]
5XPLX-ray2.05C740-752[»]
5YP5X-ray2.65B688-695[»]
5Z12X-ray2.75F/I687-695[»]
H/J687-692[»]
6EL6X-ray2.40B740-753[»]
6EL7X-ray2.18B740-753[»]
6EL9X-ray2.19B740-753[»]
ProteinModelPortaliQ15596
SMRiQ15596
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115761, 77 interactors
ComplexPortaliCPX-702 PPARgamma-NCOA2 activated nuclear receptor complex
CPX-816 RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex
CORUMiQ15596
DIPiDIP-5997N
ELMiQ15596
IntActiQ15596, 27 interactors
MINTiQ15596
STRINGi9606.ENSP00000399968

Chemistry databases

BindingDBiQ15596
DrugBankiDB06871 17-METHYL-17-ALPHA-DIHYDROEQUILENIN
DB07863 2-chloro-5-nitro-N-phenylbenzamide
DB07708 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
DB07712 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
DB01645 Genistein
DB02998 Methyltrienolone
DB08773 RALOXIFENE CORE
DB08601 tributylstannanyl

PTM databases

iPTMnetiQ15596
PhosphoSitePlusiQ15596

Polymorphism and mutation databases

BioMutaiNCOA2
DMDMi13626594

Proteomic databases

EPDiQ15596
MaxQBiQ15596
PaxDbiQ15596
PeptideAtlasiQ15596
PRIDEiQ15596
ProteomicsDBi60649

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452400; ENSP00000399968; ENSG00000140396
GeneIDi10499
KEGGihsa:10499
UCSCiuc003xyn.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10499
DisGeNETi10499
EuPathDBiHostDB:ENSG00000140396.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCOA2
HGNCiHGNC:7669 NCOA2
HPAiHPA060243
MIMi601993 gene
neXtProtiNX_Q15596
OpenTargetsiENSG00000140396
PharmGKBiPA31471

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQ5S Eukaryota
ENOG410XPF9 LUCA
GeneTreeiENSGT00530000063109
HOGENOMiHOG000230947
HOVERGENiHBG052583
InParanoidiQ15596
KOiK11255
OMAiVNMNPPQ
OrthoDBiEOG091G00US
PhylomeDBiQ15596
TreeFamiTF332652

Enzyme and pathway databases

ReactomeiR-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-159418 Recycling of bile acids and salts
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-1989781 PPARA activates gene expression
R-HSA-211976 Endogenous sterols
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-3214847 HATs acetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiQ15596
SIGNORiQ15596

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCOA2 human
EvolutionaryTraceiQ15596

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Nuclear_receptor_coactivator_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10499

Protein Ontology

More...
PROi
PR:Q15596

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140396 Expressed in 237 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_NCOA2
ExpressionAtlasiQ15596 baseline and differential
GenevisibleiQ15596 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028822 NCOA2
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF2 PTHR10684:SF2, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15596
Secondary accession number(s): Q14CD2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1997
Last modified: December 5, 2018
This is version 210 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again