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UniProtKB - Q15596 (NCOA2_HUMAN)

Entry version 231 (25 May 2022)
Sequence version 2 (01 May 1997)
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Protein

Nuclear receptor coactivator 2

Gene

NCOA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:8670870, PubMed:23508108, PubMed:9430642).

Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:8670870, PubMed:23508108, PubMed:9430642).

Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:8670870, PubMed:23508108, PubMed:9430642).

Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression (PubMed:8670870, PubMed:23508108, PubMed:9430642).

Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108).

Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15596

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1368082, RORA activates gene expression
R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-159418, Recycling of bile acids and salts
R-HSA-192105, Synthesis of bile acids and bile salts
R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-1989781, PPARA activates gene expression
R-HSA-211976, Endogenous sterols
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-3214847, HATs acetylate histones
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300, SUMOylation of transcription cofactors
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-400253, Circadian Clock
R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9707564, Cytoprotection by HMOX1
R-HSA-9707616, Heme signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15596

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15596

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivator 2
Short name:
NCoA-2
Alternative name(s):
Class E basic helix-loop-helix protein 75
Short name:
bHLHe75
Transcriptional intermediary factor 21 Publication
Short name:
hTIF21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCOA2
Synonyms:BHLHE75, SRC2, TIF21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7669, NCOA2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601993, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15596

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140396

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi644 – 645LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 693-A-A-694 and 748-A-A-749. 1 Publication2
Mutagenesisi693 – 694LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 644-A-A-665 and 748-A-A-749. 1 Publication2
Mutagenesisi748 – 749LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 644-A-A-665 and 693-A-A-694. 1 Publication2
Mutagenesisi1079 – 1083LLDQL → AADQA: Reduces transcriptional coactivation and disrupts interaction with CREBBP/CBP. 1 Publication5
Mutagenesisi1081 – 1082DQ → AA: Has little effect on transcriptional coactivation. 1 Publication2

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei869 – 870Breakpoint for translocation to form KAT6A-NCOA23 Publications2

Organism-specific databases

DisGeNET

More...DisGeNETi		10499

Open Targets

More...OpenTargetsi		ENSG00000140396

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31471

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15596, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB08175, (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
DB07678, (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL
DB07707, (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL
DB06871, 17-METHYL-17-ALPHA-DIHYDROEQUILENIN
DB08773, 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol
DB08402, 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
DB08398, 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
DB07863, 2-chloro-5-nitro-N-phenylbenzamide
DB07708, 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
DB07712, 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
DB06898, 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol
DB08048, 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL
DB08595, 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
DB07195, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
DB07086, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
DB07087, 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
DB08047, 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol
DB08320, DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE
DB00255, Diethylstilbestrol
DB07932, dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB01645, Genistein
DB02998, Metribolone
DB07080, TO-901317
DB08601, Tributyltin

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NCOA2

Domain mapping of disease mutations (DMDM)

More...DMDMi		13626594

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000944022 – 1464Nuclear receptor coactivator 2Add BLAST1463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei338Asymmetric dimethylarginineBy similarity1
Modified residuei487PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1
Modified residuei636N6-acetyllysineBy similarity1
Modified residuei640N6-acetyllysineCombined sources1
Cross-linki648Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei682PhosphoserineCombined sources1
Modified residuei699PhosphoserineCombined sources1
Cross-linki705Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei736PhosphoserineCombined sources1
Modified residuei771PhosphoserineCombined sources1
Modified residuei780N6-acetyllysineCombined sources1
Modified residuei785N6-acetyllysineCombined sources1
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei864Asymmetric dimethylarginineBy similarity1
Modified residuei874Asymmetric dimethylarginineBy similarity1
Modified residuei1173Asymmetric dimethylarginineCombined sources1
Modified residuei1177Asymmetric dimethylarginineCombined sources1
Modified residuei1190Asymmetric dimethylarginineCombined sources1
Modified residuei1196Asymmetric dimethylarginineCombined sources1
Modified residuei1203Asymmetric dimethylarginineCombined sources1
Modified residuei1221Asymmetric dimethylarginineCombined sources1
Modified residuei1240Asymmetric dimethylarginineBy similarity1
Modified residuei1261Omega-N-methylarginineCombined sources1
Modified residuei1266Asymmetric dimethylarginineCombined sources1
Cross-linki1454Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated. Deacetylation at Lys-780 by SIRT6 stimulates its ability to coactivate PPARA.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15596

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15596

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15596

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15596

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15596

PeptideAtlas

More...PeptideAtlasi		Q15596

PRoteomics IDEntifications database

More...PRIDEi		Q15596

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60649

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q15596, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15596

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15596

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140396, Expressed in epithelium of mammary gland and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15596, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15596, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140396, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP.

Interacts (via C-terminus) with CREBBP.

Interacts with ESR1, HIF1A, NCOA1, APEX1, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300.

Interacts with CASP8AP2 and TTLL5/STAMP.

Interacts with PSMB9 and DDX5.

Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif).

Interacts with RWDD3.

Interacts with CLOCK and ARNTL/BMAL1 (By similarity).

Interacts with NR4A3; potentiates the activity of the NR4A3 (By similarity).

Interacts with NR1H3 (PubMed:19481530).

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115761, 91 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-513, RXRalpha-NCOA2 activated retinoic acid receptor complex
CPX-5156, ERalpha-NCOA2 activated estrogen receptor complex
CPX-666, RARalpha-NCOA2 activated retinoic acid receptor complex
CPX-702, PPARgamma-NCOA2 activated nuclear receptor complex
CPX-816, RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15596

Database of interacting proteins

More...DIPi		DIP-5997N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q15596

Protein interaction database and analysis system

More...IntActi		Q15596, 54 interactors

Molecular INTeraction database

More...MINTi		Q15596

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000399968

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q15596

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15596, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11464
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q15596

Small Angle Scattering Biological Data Bank

More...SASBDBi		Q15596

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15596

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15596

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 83bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini119 – 183PASPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40
Regioni468 – 513DisorderedSequence analysisAdd BLAST46
Regioni557 – 683DisorderedSequence analysisAdd BLAST127
Regioni691 – 743CASP8AP2-bindingBy similarityAdd BLAST53
Regioni709 – 737DisorderedSequence analysisAdd BLAST29
Regioni730 – 1121Interaction with ARNTLBy similarityAdd BLAST392
Regioni973 – 1003DisorderedSequence analysisAdd BLAST31
Regioni1017 – 1038DisorderedSequence analysisAdd BLAST22
Regioni1051 – 1074DisorderedSequence analysisAdd BLAST24
Regioni1441 – 1464DisorderedSequence analysisAdd BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi641 – 645LXXLL motif 15
Motifi690 – 694LXXLL motif 25
Motifi745 – 749LXXLL motif 35
Motifi878 – 882LXXLL motif 45
Motifi1079 – 1087LLXXLXXXL motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 40Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi468 – 488Polar residuesSequence analysisAdd BLAST21
Compositional biasi557 – 572Polar residuesSequence analysisAdd BLAST16
Compositional biasi595 – 619Polar residuesSequence analysisAdd BLAST25
Compositional biasi635 – 680Polar residuesSequence analysisAdd BLAST46
Compositional biasi712 – 729Polar residuesSequence analysisAdd BLAST18
Compositional biasi988 – 1003Polar residuesSequence analysisAdd BLAST16
Compositional biasi1018 – 1034Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.1 Publication
The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.1 Publication
Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3561, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183021

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001988_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15596

Identification of Orthologs from Complete Genome Data

More...OMAi		DSNMPPV

Database of Orthologous Groups

More...OrthoDBi		59971at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15596

TreeFam database of animal gene trees

More...TreeFami		TF332652

Family and domain databases

Conserved Domains Database

More...CDDi		cd00130, PAS, 1 hit

Database of protein disorder

More...DisProti		DP01880

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.280.10, 1 hit
6.10.140.20, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00082

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR032565, DUF4927
IPR036638, HLH_DNA-bd_sf
IPR010011, NCO_DUF1518
IPR028822, NCOA2
IPR009110, Nuc_rcpt_coact
IPR014920, Nuc_rcpt_coact_Ncoa-typ
IPR037077, Nuc_rcpt_coact_Ncoa_int_sf
IPR017426, Nuclear_rcpt_coactivator
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR014935, SRC/p160_LXXLL

The PANTHER Classification System

More...PANTHERi		PTHR10684, PTHR10684, 1 hit
PTHR10684:SF2, PTHR10684:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07469, DUF1518, 1 hit
PF16279, DUF4927, 1 hit
PF08815, Nuc_rec_co-act, 1 hit
PF00989, PAS, 1 hit
PF08832, SRC-1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038181, Nuclear_receptor_coactivator, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01151, DUF1518, 1 hit
SM00353, HLH, 1 hit
SM00091, PAS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
SSF69125, SSF69125, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q15596-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRNTEKRNRE QENKYIEELA 
        60         70         80         90        100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS 
       110        120        130        140        150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGNVVFVS ENVTQYLRYN 
       160        170        180        190        200
QEELMNKSVY SILHVGDHTE FVKNLLPKSI VNGGSWSGEP PRRNSHTFNC 
       210        220        230        240        250
RMLVKPLPDS EEEGHDNQEA HQKYETMQCF AVSQPKSIKE EGEDLQSCLI 
       260        270        280        290        300
CVARRVPMKE RPVLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV 
       310        320        330        340        350
RRCIQKFHAQ HEGESVSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ 
       360        370        380        390        400
TKSKLIRSQT TNEPQLVISL HMLHREQNVC VMNPDLTGQT MGKPLNPISS 
       410        420        430        440        450
NSPAHQALCS GNPGQDMTLS SNINFPINGP KEQMGMPMGR FGGSGGMNHV 
       460        470        480        490        500
SGMQATTPQG SNYALKMNSP SQSSPGMNPG QPTSMLSPRH RMSPGVAGSP 
       510        520        530        540        550
RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGS 
       560        570        580        590        600
SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 
       610        620        630        640        650
ESSCHPGEQK ETNDPNLPPA VSSERADGQS RLHDSKGQTK LLQLLTTKSD 
       660        670        680        690        700
QMEPSPLASS LSDTNKDSTG SLPGSGSTHG TSLKEKHKIL HRLLQDSSSP 
       710        720        730        740        750
VDLAKLTAEA TGKDLSQESS STAPGSEVTI KQEPVSPKKK ENALLRYLLD 
       760        770        780        790        800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTEKEE MSFEPGDQPG 
       810        820        830        840        850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP AGSVDKQAII NDLMQLTAEN 
       860        870        880        890        900
SPVTPVGAQK TALRISQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG 
       910        920        930        940        950
PFPPIRNSSP YSVIPQPGMM GNQGMIGNQG NLGNSSTGMI GNSASRPTMP 
       960        970        980        990       1000
SGEWAPQSSA VRVTCAATTS AMNRPVQGGM IRNPAASIPM RPSSQPGQRQ 
      1010       1020       1030       1040       1050
TLQSQVMNIG PSELEMNMGG PQYSQQQAPP NQTAPWPESI LPIDQASFAS 
      1060       1070       1080       1090       1100
QNRQPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL 
      1110       1120       1130       1140       1150
GIPELVSQSQ AVDPEQFSSQ DSNIMLEQKA PVFPQQYASQ AQMAQGSYSP 
      1160       1170       1180       1190       1200
MQDPNFHTMG QRPSYATLRM QPRPGLRPTG LVQNQPNQLR LQLQHRLQAQ 
      1210       1220       1230       1240       1250
QNRQPLMNQI SNVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR 
      1260       1270       1280       1290       1300
QMHQQQQVQQ RTLMMRGQGL NMTPSMVAPS GMPATMSNPR IPQANAQQFP 
      1310       1320       1330       1340       1350
FPPNYGISQQ PDPGFTGATT PQSPLMSPRM AHTQSPMMQQ SQANPAYQAP 
      1360       1370       1380       1390       1400
SDINGWAQGN MGGNSMFSQQ SPPHFGQQAN TSMYSNNMNI NVSMATNTGG 
      1410       1420       1430       1440       1450
MSSMNQMTGQ ISMTSVTSVP TSGLSSMGPE QVNDPALRGG NLFPNQLPGM 
      1460 
DMIKQEGDTT RKYC
Length:1,464
Mass (Da):159,157
Last modified:May 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A61AA5D1878304B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBB6H0YBB6_HUMAN
Nuclear receptor coactivator 2
NCOA2
590Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWM1E7EWM1_HUMAN
Nuclear receptor coactivator 2
NCOA2
946Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFN9E5RFN9_HUMAN
Nuclear receptor coactivator 2
NCOA2
16Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMT0A0A1D5RMT0_HUMAN
Nuclear receptor coactivator 2
NCOA2
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0245461282M → I1 PublicationCorresponds to variant dbSNP:rs2228591Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X97674 mRNA Translation: CAA66263.1
BC114383 mRNA Translation: AAI14384.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47872.1

NCBI Reference Sequences

More...RefSeqi		NP_001308632.1, NM_001321703.1
NP_001308636.1, NM_001321707.1
NP_001308640.1, NM_001321711.1
NP_001308641.1, NM_001321712.1
NP_001308642.1, NM_001321713.1
NP_006531.1, NM_006540.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000452400.7; ENSP00000399968.2; ENSG00000140396.13

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10499

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000452400.7; ENSP00000399968.2; NM_006540.4; NP_006531.1

UCSC genome browser

More...UCSCi		uc003xyn.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97674 mRNA Translation: CAA66263.1
BC114383 mRNA Translation: AAI14384.1
CCDSiCCDS47872.1
RefSeqiNP_001308632.1, NM_001321703.1
NP_001308636.1, NM_001321707.1
NP_001308640.1, NM_001321711.1
NP_001308641.1, NM_001321712.1
NP_001308642.1, NM_001321713.1
NP_006531.1, NM_006540.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GWQX-ray2.45C/D688-696[»]
1GWRX-ray2.40C/D742-750[»]
1M2ZX-ray2.50B/E734-754[»]
1MV9X-ray1.90B686-698[»]
1MVCX-ray1.90B686-698[»]
1MZNX-ray1.90B/D/F/H686-698[»]
1P93X-ray2.70E/F/G/H740-751[»]
1T63X-ray2.07B740-753[»]
1T65X-ray1.66B686-698[»]
1UHLX-ray2.90C/D687-696[»]
1YOKX-ray2.50B/C740-753[»]
1ZDTX-ray2.10P/Q741-752[»]
1ZDUX-ray2.50P/Q741-751[»]
1ZKYX-ray2.25C/D686-698[»]
2AO6X-ray1.89B740-753[»]
2B1VX-ray1.80C/D686-698[»]
2B1ZX-ray1.78C/D686-698[»]
2B23X-ray2.10C/D686-698[»]
2FAIX-ray2.10C/D686-698[»]
2G44X-ray2.65C/D686-698[»]
2G5OX-ray2.30C/D686-698[»]
2LDCNMR-A687-697[»]
2P15X-ray1.94C/D686-698[»]
2P1TX-ray1.80B686-698[»]
2P1UX-ray2.20B686-698[»]
2P1VX-ray2.20B686-698[»]
2Q7JX-ray1.90B740-753[»]
2Q7LX-ray1.92B740-753[»]
2YJDX-ray1.93C/D687-697[»]
2ZXZX-ray3.00B686-698[»]
2ZY0X-ray2.90B/D686-698[»]
3A9EX-ray2.75I686-698[»]
3CLDX-ray2.84C/H740-751[»]
3DZUX-ray3.20E/G685-697[»]
3DZYX-ray3.10E/G685-697[»]
3E00X-ray3.10E/G685-697[»]
3E7CX-ray2.15D/H741-751[»]
3E94X-ray1.90B686-698[»]
3ERDX-ray2.03C/D686-698[»]
3FUGX-ray2.00B686-698[»]
3GN8X-ray2.50C/E734-754[»]
3K22X-ray2.10D/H740-751[»]
3K23X-ray3.00D/E/F740-751[»]
3KWYX-ray2.30B686-698[»]
3KYTX-ray2.35C686-697[»]
3L0EX-ray2.30B740-751[»]
3L0JX-ray2.40C688-697[»]
3L0LX-ray1.74C/E685-697[»]
3O1DX-ray2.40B686-698[»]
3O1EX-ray2.50B686-698[»]
3OAPX-ray2.05B686-696[»]
3OZJX-ray2.10B/D686-696[»]
3PCUX-ray2.00B687-696[»]
3PLZX-ray1.75C/D740-753[»]
3Q95X-ray2.05C/D686-698[»]
3R5MX-ray2.80B/D687-696[»]
3UP0X-ray1.60P/Q740-753[»]
3UP3X-ray1.25P741-754[»]
4CSJX-ray2.30B741-753[»]
4DOSX-ray2.00B/C740-753[»]
4E2JX-ray2.50C/E741-752[»]
4FHHX-ray2.33B686-698[»]
4FHIX-ray2.40B686-698[»]
4IA1X-ray2.44B686-698[»]
4IA2X-ray2.95B686-698[»]
4IA3X-ray2.70B686-698[»]
4IA7X-ray2.70B686-698[»]
4IQRX-ray2.90I/J/K/L685-697[»]
4IU7X-ray2.29C/D687-696[»]
4IUIX-ray2.30C/D687-696[»]
4IV2X-ray2.14C/D687-696[»]
4IV4X-ray2.30C/D687-696[»]
4IVWX-ray2.06C/D687-696[»]
4IVYX-ray1.95C/D687-696[»]
4IW6X-ray1.98C/D687-696[»]
4IW8X-ray2.04C/D687-696[»]
4IWCX-ray2.24C/D687-696[»]
4IWFX-ray1.93C/D687-696[»]
4K4JX-ray2.00B686-698[»]
4K6IX-ray2.10B686-698[»]
4M8EX-ray2.40B686-696[»]
4M8HX-ray2.20B686-696[»]
4NIEX-ray2.01C/D686-697[»]
4NQAX-ray3.10C/D/J/K686-698[»]
4OC7X-ray2.50B686-698[»]
4P6WX-ray1.95B741-752[»]
4P6XX-ray2.50B/D/F/H/J/L740-753[»]
4PLDX-ray1.75B740-753[»]
4PLEX-ray1.75B/D/F/H740-753[»]
4POHX-ray2.30B686-698[»]
4POJX-ray2.00B686-698[»]
4PP3X-ray2.00B686-698[»]
4PP5X-ray2.00B686-698[»]
4PP6X-ray2.20C/D688-696[»]
4PPPX-ray2.69C/D688-696[»]
4PPSX-ray1.93C/D687-698[»]
4PXMX-ray1.90C/D686-698[»]
4Q0AX-ray1.90D687-695[»]
4Q13X-ray2.24C/D686-698[»]
4QE6X-ray1.65B740-752[»]
4QE8X-ray2.62C/D740-752[»]
4RFWX-ray2.40G686-698[»]
4RMCX-ray2.70B686-698[»]
4RMDX-ray1.90B686-698[»]
4RMEX-ray2.30B686-698[»]
4RUOX-ray2.81B686-698[»]
4UDCX-ray2.50B740-753[»]
4UDDX-ray1.80B740-753[»]
4WG0X-ray1.82A/B/C/D/E/F/G/H/I/J/K/L/M742-752[»]
4ZN7X-ray1.93C/D686-698[»]
4ZN9X-ray2.21C/D686-698[»]
4ZNHX-ray1.93C/D686-698[»]
4ZNSX-ray1.86C/D686-698[»]
4ZNTX-ray1.90C/D686-698[»]
4ZNUX-ray2.40C/D686-698[»]
4ZNVX-ray1.77C/D686-698[»]
4ZNWX-ray2.31C/D686-698[»]
4ZO1X-ray3.22A686-694[»]
4ZSHX-ray1.80B686-698[»]
5APHX-ray1.54C686-697[»]
5APJX-ray2.08C686-697[»]
5DI7X-ray2.24C/D686-699[»]
5DIDX-ray2.24C/D686-699[»]
5DIEX-ray2.24C/D686-699[»]
5DIGX-ray2.24C/D686-699[»]
5DK9X-ray2.28C/D686-699[»]
5DKBX-ray2.40C/D686-699[»]
5DKEX-ray2.60C/D686-699[»]
5DKGX-ray2.15C/D686-699[»]
5DKSX-ray2.60C/D686-699[»]
5DL4X-ray2.10C/D686-699[»]
5DLRX-ray2.26C/D686-699[»]
5DMCX-ray2.40C/D686-699[»]
5DMFX-ray2.40C/D686-699[»]
5DP0X-ray2.38C/D686-699[»]
5DRJX-ray2.07C/D686-699[»]
5DRMX-ray2.24C/D686-699[»]
5DTVX-ray2.29C/D686-699[»]
5DU5X-ray2.19C/D686-699[»]
5DUEX-ray2.09C/D686-699[»]
5DUGX-ray2.25C/D686-699[»]
5DUHX-ray2.24C/D686-699[»]
5DVSX-ray2.28C/D686-699[»]
5DVVX-ray2.50C/D686-699[»]
5DWEX-ray1.92C/D686-699[»]
5DWGX-ray2.30C/D686-699[»]
5DWIX-ray2.43C/D686-699[»]
5DWJX-ray2.00C/D686-699[»]
5DX3X-ray2.09C/D687-697[»]
5DXBX-ray2.08D/E687-697[»]
5DXEX-ray1.50C/D687-697[»]
5DXGX-ray1.86C/D687-697[»]
5DXKX-ray2.23C/D686-699[»]
5DXMX-ray2.37C/D686-699[»]
5DXPX-ray2.20C/D686-699[»]
5DXQX-ray2.40C/D686-699[»]
5DXRX-ray2.28C/D686-699[»]
5DY8X-ray2.03C/D686-699[»]
5DYBX-ray2.27C/D686-699[»]
5DYDX-ray2.48C/D686-699[»]
5DZ0X-ray2.24C/D686-699[»]
5DZ1X-ray2.20C/D686-699[»]
5DZ3X-ray2.15C/D686-699[»]
5DZHX-ray2.11C/D686-699[»]
5DZIX-ray1.90C/D686-699[»]
5E0WX-ray2.00C/D686-699[»]
5E0XX-ray2.01C/D686-699[»]
5E14X-ray2.22C/D686-699[»]
5E15X-ray2.10C/D686-699[»]
5E19X-ray2.24C/D686-699[»]
5E1CX-ray1.98C/D686-699[»]
5EC9X-ray2.30B686-696[»]
5EGVX-ray2.86C/D686-699[»]
5EHJX-ray2.50C/D686-699[»]
5EI1X-ray2.40C/D686-699[»]
5EITX-ray2.68C/D686-699[»]
5G3JX-ray2.40B740-753[»]
5G42X-ray1.72C688-697[»]
5G43X-ray2.58C686-697[»]
5G44X-ray1.84C686-697[»]
5G45X-ray2.07C688-697[»]
5G46X-ray1.76C688-697[»]
5G5WX-ray2.20B740-753[»]
5H1EX-ray2.60C740-752[»]
5HYRX-ray2.27F/G687-697[»]
5I4VX-ray2.61A/B/E/F687-699[»]
5IAWX-ray2.58C/D742-751[»]
5ICKX-ray2.47C/D742-752[»]
5KCCX-ray2.39C/D686-699[»]
5KCDX-ray1.82C/D686-699[»]
5KCEX-ray1.85C/D686-698[»]
C/D687-696[»]
5KCFX-ray2.07C/D686-699[»]
5KCTX-ray1.60C/D686-699[»]
5KCUX-ray2.03C/D686-699[»]
5KCWX-ray1.91C/D686-699[»]
5KD9X-ray1.78C/D686-699[»]
5KR9X-ray2.25C/D686-699[»]
5KRAX-ray2.40C/D/G/H686-699[»]
5KRCX-ray2.40C/D686-699[»]
5KRFX-ray2.19C/D686-699[»]
5KRHX-ray2.24C/D686-699[»]
5KRIX-ray2.25C/D686-699[»]
5KRJX-ray2.70C/D686-699[»]
5KRKX-ray2.39C/D686-699[»]
5KRLX-ray2.40C/D686-699[»]
5KRMX-ray2.24C/D686-699[»]
5KROX-ray2.10C/D686-699[»]
5L11X-ray1.85C740-753[»]
5LGAX-ray2.50B686-698[»]
5LYQX-ray2.17B686-698[»]
5MK4X-ray2.00B/D686-696[»]
5NFPX-ray2.10B740-753[»]
5NFTX-ray2.30B740-753[»]
5NI5X-ray2.30C684-698[»]
5NI7X-ray2.45C684-698[»]
5NI8X-ray1.94C684-698[»]
5NIBX-ray1.82C684-698[»]
5Q17X-ray2.10B741-752[»]
5SYZX-ray1.93C740-754[»]
5T1ZX-ray2.10C/D686-698[»]
5TLDX-ray2.38C/D686-698[»]
5TLFX-ray2.20C/D686-698[»]
5TLGX-ray2.23C/D686-698[»]
5TLLX-ray2.42C/D686-698[»]
5TLMX-ray2.50C/D686-698[»]
5TLOX-ray2.28C/D686-698[»]
5TLPX-ray2.08C/D686-698[»]
5TLTX-ray1.90C/D686-698[»]
5TLUX-ray2.22C/D686-698[»]
5TLVX-ray2.32C/D686-698[»]
5TLXX-ray2.10C/D686-698[»]
5TLYX-ray2.14C/D686-698[»]
5TM1X-ray2.23C/D686-698[»]
5TM2X-ray2.60C/D686-698[»]
5TM3X-ray2.19C/D686-698[»]
5TM4X-ray2.25C/D686-698[»]
5TM5X-ray2.24C/D686-698[»]
5TM6X-ray2.54C/D686-698[»]
5TM7X-ray2.40C/D686-698[»]
5TM8X-ray1.99C/D686-698[»]
5TM9X-ray2.50C/D686-698[»]
5TMLX-ray2.25C/D686-698[»]
5TMMX-ray2.20C/D686-698[»]
5TMOX-ray2.17C/D686-698[»]
5TMQX-ray2.24C/D686-698[»]
5TMRX-ray2.30C/D686-698[»]
5TMSX-ray2.24C/D686-698[»]
5TMTX-ray2.05C/D686-698[»]
5TMUX-ray2.43C/D686-698[»]
5TMVX-ray2.38C/D686-698[»]
5TMWX-ray2.29C/D686-698[»]
5TMZX-ray2.21C/D686-698[»]
5TN1X-ray2.06C/D686-698[»]
5TN3X-ray2.54C/D686-698[»]
5TN4X-ray1.86C/D686-698[»]
5TN5X-ray1.89C/D686-698[»]
5TN6X-ray2.09C/D686-698[»]
5TN7X-ray2.24C/D686-698[»]
5TN8X-ray2.65C/D686-698[»]
5U2DX-ray1.86C/D686-698[»]
5UANX-ray3.51C/D687-696[»]
5VB3X-ray1.95A685-697[»]
5VB5X-ray2.23A685-697[»]
5VB6X-ray2.04A685-697[»]
5VB7X-ray2.33A685-697[»]
5VQKX-ray3.10A685-697[»]
5VQLX-ray2.70A685-697[»]
5WGQX-ray2.30E/F687-697[»]
5WZXX-ray2.95C/D741-752[»]
5XPLX-ray2.05C740-752[»]
5Y1JX-ray2.00U742-751[»]
5Y49X-ray2.40D/E741-751[»]
5YP5X-ray2.65B688-695[»]
5YXBX-ray2.95B741-751[»]
5YXDX-ray2.98B741-751[»]
5YXJX-ray2.62C/D741-751[»]
5YXLX-ray2.24B/D743-750[»]
5Z12X-ray2.75F/I687-695[»]
H/J687-692[»]
6CZNX-ray2.50C/D686-698[»]
6D0FX-ray2.50C/D687-696[»]
6EL6X-ray2.40B740-753[»]
6EL7X-ray2.18B740-753[»]
6EL9X-ray2.19B740-753[»]
6ESNX-ray1.84C686-697[»]
6KKBX-ray1.70D741-751[»]
6KKEX-ray2.58C741-751[»]
6KNUX-ray2.70C741-751[»]
6KNVX-ray2.80C741-751[»]
6KNWX-ray2.67C741-751[»]
6LB4X-ray1.50B686-698[»]
6LB5X-ray2.40B/D686-698[»]
6LB6X-ray2.40B686-698[»]
6LITX-ray2.00D/E686-696[»]
6OQXX-ray2.00C740-754[»]
6OQYX-ray2.23C740-754[»]
6OR1X-ray2.17C740-754[»]
6R7AX-ray2.13C684-698[»]
6R7JX-ray1.84C684-698[»]
6R7KX-ray1.54C684-698[»]
6SJMX-ray2.52B686-699[»]
6STIX-ray1.89B686-698[»]
6VC2X-ray1.70C740-754[»]
6VIFX-ray2.26B740-753[»]
7A77X-ray1.50B686-699[»]
7A78X-ray1.72B686-699[»]
7A79X-ray2.05C/D686-699[»]
7B88X-ray2.38B686-699[»]
7B9OX-ray2.05C686-699[»]
7D42X-ray2.70B740-753[»]
7JHDX-ray2.40C/D686-698[»]
7KCOX-ray1.86C/D685-697[»]
7NELX-ray1.45C/D686-699[»]
7NFBX-ray1.33C/D686-699[»]
AlphaFoldDBiQ15596
SASBDBiQ15596
SMRiQ15596
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115761, 91 interactors
ComplexPortaliCPX-513, RXRalpha-NCOA2 activated retinoic acid receptor complex
CPX-5156, ERalpha-NCOA2 activated estrogen receptor complex
CPX-666, RARalpha-NCOA2 activated retinoic acid receptor complex
CPX-702, PPARgamma-NCOA2 activated nuclear receptor complex
CPX-816, RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex
CORUMiQ15596
DIPiDIP-5997N
ELMiQ15596
IntActiQ15596, 54 interactors
MINTiQ15596
STRINGi9606.ENSP00000399968

Chemistry databases

BindingDBiQ15596
DrugBankiDB08175, (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
DB07678, (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL
DB07707, (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL
DB06871, 17-METHYL-17-ALPHA-DIHYDROEQUILENIN
DB08773, 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol
DB08402, 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
DB08398, 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
DB07863, 2-chloro-5-nitro-N-phenylbenzamide
DB07708, 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
DB07712, 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
DB06898, 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol
DB08048, 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL
DB08595, 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
DB07195, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
DB07086, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
DB07087, 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
DB08047, 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol
DB08320, DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE
DB00255, Diethylstilbestrol
DB07932, dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB01645, Genistein
DB02998, Metribolone
DB07080, TO-901317
DB08601, Tributyltin

PTM databases

GlyGeniQ15596, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ15596
PhosphoSitePlusiQ15596

Genetic variation databases

BioMutaiNCOA2
DMDMi13626594

Proteomic databases

EPDiQ15596
jPOSTiQ15596
MassIVEiQ15596
MaxQBiQ15596
PaxDbiQ15596
PeptideAtlasiQ15596
PRIDEiQ15596
ProteomicsDBi60649

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6252, 301 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		10499

Genome annotation databases

EnsembliENST00000452400.7; ENSP00000399968.2; ENSG00000140396.13
GeneIDi10499
KEGGihsa:10499
MANE-SelectiENST00000452400.7; ENSP00000399968.2; NM_006540.4; NP_006531.1
UCSCiuc003xyn.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10499
DisGeNETi10499

GeneCards: human genes, protein and diseases

More...GeneCardsi		NCOA2
HGNCiHGNC:7669, NCOA2
HPAiENSG00000140396, Low tissue specificity
MIMi601993, gene
neXtProtiNX_Q15596
OpenTargetsiENSG00000140396
PharmGKBiPA31471
VEuPathDBiHostDB:ENSG00000140396

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3561, Eukaryota
GeneTreeiENSGT00950000183021
HOGENOMiCLU_001988_0_0_1
InParanoidiQ15596
OMAiDSNMPPV
OrthoDBi59971at2759
PhylomeDBiQ15596
TreeFamiTF332652

Enzyme and pathway databases

PathwayCommonsiQ15596
ReactomeiR-HSA-1368082, RORA activates gene expression
R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-159418, Recycling of bile acids and salts
R-HSA-192105, Synthesis of bile acids and bile salts
R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-1989781, PPARA activates gene expression
R-HSA-211976, Endogenous sterols
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-3214847, HATs acetylate histones
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300, SUMOylation of transcription cofactors
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-400253, Circadian Clock
R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9707564, Cytoprotection by HMOX1
R-HSA-9707616, Heme signaling
SignaLinkiQ15596
SIGNORiQ15596

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10499, 25 hits in 1096 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NCOA2, human
EvolutionaryTraceiQ15596

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Nuclear_receptor_coactivator_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10499
PharosiQ15596, Tbio

Protein Ontology

More...PROi		PR:Q15596
RNActiQ15596, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140396, Expressed in epithelium of mammary gland and 249 other tissues
ExpressionAtlasiQ15596, baseline and differential
GenevisibleiQ15596, HS

Family and domain databases

CDDicd00130, PAS, 1 hit
DisProtiDP01880
Gene3Di4.10.280.10, 1 hit
6.10.140.20, 1 hit
IDEALiIID00082
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR032565, DUF4927
IPR036638, HLH_DNA-bd_sf
IPR010011, NCO_DUF1518
IPR028822, NCOA2
IPR009110, Nuc_rcpt_coact
IPR014920, Nuc_rcpt_coact_Ncoa-typ
IPR037077, Nuc_rcpt_coact_Ncoa_int_sf
IPR017426, Nuclear_rcpt_coactivator
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR014935, SRC/p160_LXXLL
PANTHERiPTHR10684, PTHR10684, 1 hit
PTHR10684:SF2, PTHR10684:SF2, 1 hit
PfamiView protein in Pfam
PF07469, DUF1518, 1 hit
PF16279, DUF4927, 1 hit
PF08815, Nuc_rec_co-act, 1 hit
PF00989, PAS, 1 hit
PF08832, SRC-1, 1 hit
PIRSFiPIRSF038181, Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151, DUF1518, 1 hit
SM00353, HLH, 1 hit
SM00091, PAS, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
SSF69125, SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15596
Secondary accession number(s): Q14CD2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1997
Last modified: May 25, 2022
This is version 231 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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