UniProtKB - Q15596 (NCOA2_HUMAN)
Nuclear receptor coactivator 2
NCOA2
Functioni
Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108).
Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
By similarity3 PublicationsGO - Molecular functioni
- aryl hydrocarbon receptor binding Source: CAFA
- chromatin binding Source: Ensembl
- nuclear receptor binding Source: UniProtKB
- nuclear receptor coactivator activity Source: BHF-UCL
- protein dimerization activity Source: InterPro
- protein domain specific binding Source: CAFA
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Source: Ensembl
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- cellular response to hormone stimulus Source: GO_Central
- cellular response to Thyroglobulin triiodothyronine Source: Ensembl
- circadian regulation of gene expression Source: UniProtKB
- locomotor rhythm Source: Ensembl
- mRNA transcription by RNA polymerase II Source: ComplexPortal
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- peroxisome proliferator activated receptor signaling pathway Source: ComplexPortal
- positive regulation of adipose tissue development Source: ComplexPortal
- positive regulation of transcription by RNA polymerase II Source: ComplexPortal
- regulation of cellular response to insulin stimulus Source: ComplexPortal
- regulation of glucose metabolic process Source: Ensembl
- regulation of transcription, DNA-templated Source: UniProtKB
- response to progesterone Source: Ensembl
Keywordsi
Molecular function | Activator |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q15596 |
Reactomei | R-HSA-1368082, RORA activates gene expression R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-159418, Recycling of bile acids and salts R-HSA-192105, Synthesis of bile acids and bile salts R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-1989781, PPARA activates gene expression R-HSA-211976, Endogenous sterols R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-3214847, HATs acetylate histones R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9707564, Cytoprotection by HMOX1 R-HSA-9707616, Heme signaling |
SignaLinki | Q15596 |
SIGNORi | Q15596 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor coactivator 2Short name: NCoA-2 Alternative name(s): Class E basic helix-loop-helix protein 75 Short name: bHLHe75 Transcriptional intermediary factor 21 Publication Short name: hTIF21 Publication |
Gene namesi | Name:NCOA2 Synonyms:BHLHE75, SRC2, TIF21 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7669, NCOA2 |
MIMi | 601993, gene |
neXtProti | NX_Q15596 |
VEuPathDBi | HostDB:ENSG00000140396 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
- RNA polymerase II transcription regulator complex Source: ComplexPortal
Other locations
- chromatin Source: NTNU_SB
- cytoplasm Source: Ensembl
- protein-containing complex Source: CAFA
- transcription regulator complex Source: ComplexPortal
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 644 – 645 | LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 693-A-A-694 and 748-A-A-749. 1 Publication | 2 | |
Mutagenesisi | 693 – 694 | LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 644-A-A-665 and 748-A-A-749. 1 Publication | 2 | |
Mutagenesisi | 748 – 749 | LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 644-A-A-665 and 693-A-A-694. 1 Publication | 2 | |
Mutagenesisi | 1079 – 1083 | LLDQL → AADQA: Reduces transcriptional coactivation and disrupts interaction with CREBBP/CBP. 1 Publication | 5 | |
Mutagenesisi | 1081 – 1082 | DQ → AA: Has little effect on transcriptional coactivation. 1 Publication | 2 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 869 – 870 | Breakpoint for translocation to form KAT6A-NCOA23 Publications | 2 |
Organism-specific databases
DisGeNETi | 10499 |
OpenTargetsi | ENSG00000140396 |
PharmGKBi | PA31471 |
Miscellaneous databases
Pharosi | Q15596, Tbio |
Chemistry databases
DrugBanki | DB08175, (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID DB07678, (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL DB07707, (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL DB06871, 17-METHYL-17-ALPHA-DIHYDROEQUILENIN DB08773, 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol DB08402, 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID DB08398, 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine DB07863, 2-chloro-5-nitro-N-phenylbenzamide DB07708, 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL DB07712, 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL DB06898, 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol DB08048, 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL DB08595, 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07195, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07086, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07087, 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB08047, 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol DB08320, DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE DB00255, Diethylstilbestrol DB07932, dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB01645, Genistein DB02998, Metribolone DB07080, TO-901317 DB08601, Tributyltin |
Genetic variation databases
BioMutai | NCOA2 |
DMDMi | 13626594 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000094402 | 2 – 1464 | Nuclear receptor coactivator 2Add BLAST | 1463 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 29 | PhosphoserineCombined sources | 1 | |
Cross-linki | 239 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 338 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 487 | PhosphoserineCombined sources | 1 | |
Modified residuei | 493 | PhosphoserineCombined sources | 1 | |
Modified residuei | 499 | PhosphoserineCombined sources | 1 | |
Modified residuei | 554 | PhosphoserineCombined sources | 1 | |
Modified residuei | 565 | PhosphoserineCombined sources | 1 | |
Modified residuei | 636 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 640 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 648 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 682 | PhosphoserineCombined sources | 1 | |
Modified residuei | 699 | PhosphoserineCombined sources | 1 | |
Cross-linki | 705 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 731 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 736 | PhosphoserineCombined sources | 1 | |
Modified residuei | 771 | PhosphoserineCombined sources | 1 | |
Modified residuei | 780 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 785 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 785 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 864 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 874 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1173 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1177 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1190 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1196 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1203 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1221 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1240 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1261 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 1266 | Asymmetric dimethylarginineCombined sources | 1 | |
Cross-linki | 1454 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q15596 |
jPOSTi | Q15596 |
MassIVEi | Q15596 |
MaxQBi | Q15596 |
PaxDbi | Q15596 |
PeptideAtlasi | Q15596 |
PRIDEi | Q15596 |
ProteomicsDBi | 60649 |
PTM databases
GlyGeni | Q15596, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q15596 |
PhosphoSitePlusi | Q15596 |
Expressioni
Gene expression databases
Bgeei | ENSG00000140396, Expressed in epithelium of mammary gland and 249 other tissues |
ExpressionAtlasi | Q15596, baseline and differential |
Genevisiblei | Q15596, HS |
Organism-specific databases
HPAi | ENSG00000140396, Low tissue specificity |
Interactioni
Subunit structurei
Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP.
Interacts (via C-terminus) with CREBBP.
Interacts with ESR1, HIF1A, NCOA1, APEX1, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300.
Interacts with CASP8AP2 and TTLL5/STAMP.
Interacts with PSMB9 and DDX5.
Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif).
Interacts with RWDD3.
Interacts with CLOCK and ARNTL/BMAL1 (By similarity).
Interacts with NR4A3; potentiates the activity of the NR4A3 (By similarity).
Interacts with NR1H3 (PubMed:19481530).
By similarity10 PublicationsBinary interactionsi
Q15596
With | #Exp. | IntAct |
---|---|---|
AR [P10275] | 3 | EBI-81236,EBI-608057 |
ESR1 [P03372] | 5 | EBI-81236,EBI-78473 |
NR5A2 - isoform 2 [O00482-1] | 2 | EBI-81236,EBI-15960777 |
RXRA [P19793] | 5 | EBI-81236,EBI-78598 |
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: CAFA
- nuclear receptor binding Source: UniProtKB
- protein dimerization activity Source: InterPro
- protein domain specific binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 115761, 91 interactors |
ComplexPortali | CPX-513, RXRalpha-NCOA2 activated retinoic acid receptor complex CPX-5156, ERalpha-NCOA2 activated estrogen receptor complex CPX-666, RARalpha-NCOA2 activated retinoic acid receptor complex CPX-702, PPARgamma-NCOA2 activated nuclear receptor complex CPX-816, RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex |
CORUMi | Q15596 |
DIPi | DIP-5997N |
ELMi | Q15596 |
IntActi | Q15596, 54 interactors |
MINTi | Q15596 |
STRINGi | 9606.ENSP00000399968 |
Chemistry databases
BindingDBi | Q15596 |
Miscellaneous databases
RNActi | Q15596, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q15596 |
SASBDBi | Q15596 |
SMRi | Q15596 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15596 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 83 | bHLHPROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 119 – 183 | PASPROSITE-ProRule annotationAdd BLAST | 65 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 40 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 468 – 513 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 557 – 683 | DisorderedSequence analysisAdd BLAST | 127 | |
Regioni | 691 – 743 | CASP8AP2-bindingBy similarityAdd BLAST | 53 | |
Regioni | 709 – 737 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 730 – 1121 | Interaction with ARNTLBy similarityAdd BLAST | 392 | |
Regioni | 973 – 1003 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1017 – 1038 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1051 – 1074 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1441 – 1464 | DisorderedSequence analysisAdd BLAST | 24 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 641 – 645 | LXXLL motif 1 | 5 | |
Motifi | 690 – 694 | LXXLL motif 2 | 5 | |
Motifi | 745 – 749 | LXXLL motif 3 | 5 | |
Motifi | 878 – 882 | LXXLL motif 4 | 5 | |
Motifi | 1079 – 1087 | LLXXLXXXL motif | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 40 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 468 – 488 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 557 – 572 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 595 – 619 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 635 – 680 | Polar residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 712 – 729 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 988 – 1003 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1018 – 1034 | Polar residuesSequence analysisAdd BLAST | 17 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00950000183021 |
HOGENOMi | CLU_001988_0_0_1 |
InParanoidi | Q15596 |
OMAi | DSNMPPV |
OrthoDBi | 59971at2759 |
PhylomeDBi | Q15596 |
TreeFami | TF332652 |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
DisProti | DP01880 |
Gene3Di | 4.10.280.10, 1 hit 6.10.140.20, 1 hit |
IDEALi | IID00082 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032565, DUF4927 IPR036638, HLH_DNA-bd_sf IPR010011, NCO_DUF1518 IPR028822, NCOA2 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 1 hit PTHR10684:SF2, PTHR10684:SF2, 1 hit |
Pfami | View protein in Pfam PF07469, DUF1518, 1 hit PF16279, DUF4927, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 1 hit |
SMARTi | View protein in SMART SM01151, DUF1518, 1 hit SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRNTEKRNRE QENKYIEELA
60 70 80 90 100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS
110 120 130 140 150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGNVVFVS ENVTQYLRYN
160 170 180 190 200
QEELMNKSVY SILHVGDHTE FVKNLLPKSI VNGGSWSGEP PRRNSHTFNC
210 220 230 240 250
RMLVKPLPDS EEEGHDNQEA HQKYETMQCF AVSQPKSIKE EGEDLQSCLI
260 270 280 290 300
CVARRVPMKE RPVLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV
310 320 330 340 350
RRCIQKFHAQ HEGESVSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ
360 370 380 390 400
TKSKLIRSQT TNEPQLVISL HMLHREQNVC VMNPDLTGQT MGKPLNPISS
410 420 430 440 450
NSPAHQALCS GNPGQDMTLS SNINFPINGP KEQMGMPMGR FGGSGGMNHV
460 470 480 490 500
SGMQATTPQG SNYALKMNSP SQSSPGMNPG QPTSMLSPRH RMSPGVAGSP
510 520 530 540 550
RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGS
560 570 580 590 600
SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA
610 620 630 640 650
ESSCHPGEQK ETNDPNLPPA VSSERADGQS RLHDSKGQTK LLQLLTTKSD
660 670 680 690 700
QMEPSPLASS LSDTNKDSTG SLPGSGSTHG TSLKEKHKIL HRLLQDSSSP
710 720 730 740 750
VDLAKLTAEA TGKDLSQESS STAPGSEVTI KQEPVSPKKK ENALLRYLLD
760 770 780 790 800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTEKEE MSFEPGDQPG
810 820 830 840 850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP AGSVDKQAII NDLMQLTAEN
860 870 880 890 900
SPVTPVGAQK TALRISQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG
910 920 930 940 950
PFPPIRNSSP YSVIPQPGMM GNQGMIGNQG NLGNSSTGMI GNSASRPTMP
960 970 980 990 1000
SGEWAPQSSA VRVTCAATTS AMNRPVQGGM IRNPAASIPM RPSSQPGQRQ
1010 1020 1030 1040 1050
TLQSQVMNIG PSELEMNMGG PQYSQQQAPP NQTAPWPESI LPIDQASFAS
1060 1070 1080 1090 1100
QNRQPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL
1110 1120 1130 1140 1150
GIPELVSQSQ AVDPEQFSSQ DSNIMLEQKA PVFPQQYASQ AQMAQGSYSP
1160 1170 1180 1190 1200
MQDPNFHTMG QRPSYATLRM QPRPGLRPTG LVQNQPNQLR LQLQHRLQAQ
1210 1220 1230 1240 1250
QNRQPLMNQI SNVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR
1260 1270 1280 1290 1300
QMHQQQQVQQ RTLMMRGQGL NMTPSMVAPS GMPATMSNPR IPQANAQQFP
1310 1320 1330 1340 1350
FPPNYGISQQ PDPGFTGATT PQSPLMSPRM AHTQSPMMQQ SQANPAYQAP
1360 1370 1380 1390 1400
SDINGWAQGN MGGNSMFSQQ SPPHFGQQAN TSMYSNNMNI NVSMATNTGG
1410 1420 1430 1440 1450
MSSMNQMTGQ ISMTSVTSVP TSGLSSMGPE QVNDPALRGG NLFPNQLPGM
1460
DMIKQEGDTT RKYC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YBB6 | H0YBB6_HUMAN | Nuclear receptor coactivator 2 | NCOA2 | 590 | Annotation score: | ||
E7EWM1 | E7EWM1_HUMAN | Nuclear receptor coactivator 2 | NCOA2 | 946 | Annotation score: | ||
E5RFN9 | E5RFN9_HUMAN | Nuclear receptor coactivator 2 | NCOA2 | 16 | Annotation score: | ||
A0A1D5RMT0 | A0A1D5RMT0_HUMAN | Nuclear receptor coactivator 2 | NCOA2 | 8 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024546 | 1282 | M → I1 PublicationCorresponds to variant dbSNP:rs2228591Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97674 mRNA Translation: CAA66263.1 BC114383 mRNA Translation: AAI14384.1 |
CCDSi | CCDS47872.1 |
RefSeqi | NP_001308632.1, NM_001321703.1 NP_001308636.1, NM_001321707.1 NP_001308640.1, NM_001321711.1 NP_001308641.1, NM_001321712.1 NP_001308642.1, NM_001321713.1 NP_006531.1, NM_006540.3 |
Genome annotation databases
Ensembli | ENST00000452400.7; ENSP00000399968.2; ENSG00000140396.13 |
GeneIDi | 10499 |
KEGGi | hsa:10499 |
MANE-Selecti | ENST00000452400.7; ENSP00000399968.2; NM_006540.4; NP_006531.1 |
UCSCi | uc003xyn.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97674 mRNA Translation: CAA66263.1 BC114383 mRNA Translation: AAI14384.1 |
CCDSi | CCDS47872.1 |
RefSeqi | NP_001308632.1, NM_001321703.1 NP_001308636.1, NM_001321707.1 NP_001308640.1, NM_001321711.1 NP_001308641.1, NM_001321712.1 NP_001308642.1, NM_001321713.1 NP_006531.1, NM_006540.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GWQ | X-ray | 2.45 | C/D | 688-696 | [»] | |
1GWR | X-ray | 2.40 | C/D | 742-750 | [»] | |
1M2Z | X-ray | 2.50 | B/E | 734-754 | [»] | |
1MV9 | X-ray | 1.90 | B | 686-698 | [»] | |
1MVC | X-ray | 1.90 | B | 686-698 | [»] | |
1MZN | X-ray | 1.90 | B/D/F/H | 686-698 | [»] | |
1P93 | X-ray | 2.70 | E/F/G/H | 740-751 | [»] | |
1T63 | X-ray | 2.07 | B | 740-753 | [»] | |
1T65 | X-ray | 1.66 | B | 686-698 | [»] | |
1UHL | X-ray | 2.90 | C/D | 687-696 | [»] | |
1YOK | X-ray | 2.50 | B/C | 740-753 | [»] | |
1ZDT | X-ray | 2.10 | P/Q | 741-752 | [»] | |
1ZDU | X-ray | 2.50 | P/Q | 741-751 | [»] | |
1ZKY | X-ray | 2.25 | C/D | 686-698 | [»] | |
2AO6 | X-ray | 1.89 | B | 740-753 | [»] | |
2B1V | X-ray | 1.80 | C/D | 686-698 | [»] | |
2B1Z | X-ray | 1.78 | C/D | 686-698 | [»] | |
2B23 | X-ray | 2.10 | C/D | 686-698 | [»] | |
2FAI | X-ray | 2.10 | C/D | 686-698 | [»] | |
2G44 | X-ray | 2.65 | C/D | 686-698 | [»] | |
2G5O | X-ray | 2.30 | C/D | 686-698 | [»] | |
2LDC | NMR | - | A | 687-697 | [»] | |
2P15 | X-ray | 1.94 | C/D | 686-698 | [»] | |
2P1T | X-ray | 1.80 | B | 686-698 | [»] | |
2P1U | X-ray | 2.20 | B | 686-698 | [»] | |
2P1V | X-ray | 2.20 | B | 686-698 | [»] | |
2Q7J | X-ray | 1.90 | B | 740-753 | [»] | |
2Q7L | X-ray | 1.92 | B | 740-753 | [»] | |
2YJD | X-ray | 1.93 | C/D | 687-697 | [»] | |
2ZXZ | X-ray | 3.00 | B | 686-698 | [»] | |
2ZY0 | X-ray | 2.90 | B/D | 686-698 | [»] | |
3A9E | X-ray | 2.75 | I | 686-698 | [»] | |
3CLD | X-ray | 2.84 | C/H | 740-751 | [»] | |
3DZU | X-ray | 3.20 | E/G | 685-697 | [»] | |
3DZY | X-ray | 3.10 | E/G | 685-697 | [»] | |
3E00 | X-ray | 3.10 | E/G | 685-697 | [»] | |
3E7C | X-ray | 2.15 | D/H | 741-751 | [»] | |
3E94 | X-ray | 1.90 | B | 686-698 | [»] | |
3ERD | X-ray | 2.03 | C/D | 686-698 | [»] | |
3FUG | X-ray | 2.00 | B | 686-698 | [»] | |
3GN8 | X-ray | 2.50 | C/E | 734-754 | [»] | |
3K22 | X-ray | 2.10 | D/H | 740-751 | [»] | |
3K23 | X-ray | 3.00 | D/E/F | 740-751 | [»] | |
3KWY | X-ray | 2.30 | B | 686-698 | [»] | |
3KYT | X-ray | 2.35 | C | 686-697 | [»] | |
3L0E | X-ray | 2.30 | B | 740-751 | [»] | |
3L0J | X-ray | 2.40 | C | 688-697 | [»] | |
3L0L | X-ray | 1.74 | C/E | 685-697 | [»] | |
3O1D | X-ray | 2.40 | B | 686-698 | [»] | |
3O1E | X-ray | 2.50 | B | 686-698 | [»] | |
3OAP | X-ray | 2.05 | B | 686-696 | [»] | |
3OZJ | X-ray | 2.10 | B/D | 686-696 | [»] | |
3PCU | X-ray | 2.00 | B | 687-696 | [»] | |
3PLZ | X-ray | 1.75 | C/D | 740-753 | [»] | |
3Q95 | X-ray | 2.05 | C/D | 686-698 | [»] | |
3R5M | X-ray | 2.80 | B/D | 687-696 | [»] | |
3UP0 | X-ray | 1.60 | P/Q | 740-753 | [»] | |
3UP3 | X-ray | 1.25 | P | 741-754 | [»] | |
4CSJ | X-ray | 2.30 | B | 741-753 | [»] | |
4DOS | X-ray | 2.00 | B/C | 740-753 | [»] | |
4E2J | X-ray | 2.50 | C/E | 741-752 | [»] | |
4FHH | X-ray | 2.33 | B | 686-698 | [»] | |
4FHI | X-ray | 2.40 | B | 686-698 | [»] | |
4IA1 | X-ray | 2.44 | B | 686-698 | [»] | |
4IA2 | X-ray | 2.95 | B | 686-698 | [»] | |
4IA3 | X-ray | 2.70 | B | 686-698 | [»] | |
4IA7 | X-ray | 2.70 | B | 686-698 | [»] | |
4IQR | X-ray | 2.90 | I/J/K/L | 685-697 | [»] | |
4IU7 | X-ray | 2.29 | C/D | 687-696 | [»] | |
4IUI | X-ray | 2.30 | C/D | 687-696 | [»] | |
4IV2 | X-ray | 2.14 | C/D | 687-696 | [»] | |
4IV4 | X-ray | 2.30 | C/D | 687-696 | [»] | |
4IVW | X-ray | 2.06 | C/D | 687-696 | [»] | |
4IVY | X-ray | 1.95 | C/D | 687-696 | [»] | |
4IW6 | X-ray | 1.98 | C/D | 687-696 | [»] | |
4IW8 | X-ray | 2.04 | C/D | 687-696 | [»] | |
4IWC | X-ray | 2.24 | C/D | 687-696 | [»] | |
4IWF | X-ray | 1.93 | C/D | 687-696 | [»] | |
4K4J | X-ray | 2.00 | B | 686-698 | [»] | |
4K6I | X-ray | 2.10 | B | 686-698 | [»] | |
4M8E | X-ray | 2.40 | B | 686-696 | [»] | |
4M8H | X-ray | 2.20 | B | 686-696 | [»] | |
4NIE | X-ray | 2.01 | C/D | 686-697 | [»] | |
4NQA | X-ray | 3.10 | C/D/J/K | 686-698 | [»] | |
4OC7 | X-ray | 2.50 | B | 686-698 | [»] | |
4P6W | X-ray | 1.95 | B | 741-752 | [»] | |
4P6X | X-ray | 2.50 | B/D/F/H/J/L | 740-753 | [»] | |
4PLD | X-ray | 1.75 | B | 740-753 | [»] | |
4PLE | X-ray | 1.75 | B/D/F/H | 740-753 | [»] | |
4POH | X-ray | 2.30 | B | 686-698 | [»] | |
4POJ | X-ray | 2.00 | B | 686-698 | [»] | |
4PP3 | X-ray | 2.00 | B | 686-698 | [»] | |
4PP5 | X-ray | 2.00 | B | 686-698 | [»] | |
4PP6 | X-ray | 2.20 | C/D | 688-696 | [»] | |
4PPP | X-ray | 2.69 | C/D | 688-696 | [»] | |
4PPS | X-ray | 1.93 | C/D | 687-698 | [»] | |
4PXM | X-ray | 1.90 | C/D | 686-698 | [»] | |
4Q0A | X-ray | 1.90 | D | 687-695 | [»] | |
4Q13 | X-ray | 2.24 | C/D | 686-698 | [»] | |
4QE6 | X-ray | 1.65 | B | 740-752 | [»] | |
4QE8 | X-ray | 2.62 | C/D | 740-752 | [»] | |
4RFW | X-ray | 2.40 | G | 686-698 | [»] | |
4RMC | X-ray | 2.70 | B | 686-698 | [»] | |
4RMD | X-ray | 1.90 | B | 686-698 | [»] | |
4RME | X-ray | 2.30 | B | 686-698 | [»] | |
4RUO | X-ray | 2.81 | B | 686-698 | [»] | |
4UDC | X-ray | 2.50 | B | 740-753 | [»] | |
4UDD | X-ray | 1.80 | B | 740-753 | [»] | |
4WG0 | X-ray | 1.82 | A/B/C/D/E/F/G/H/I/J/K/L/M | 742-752 | [»] | |
4ZN7 | X-ray | 1.93 | C/D | 686-698 | [»] | |
4ZN9 | X-ray | 2.21 | C/D | 686-698 | [»] | |
4ZNH | X-ray | 1.93 | C/D | 686-698 | [»] | |
4ZNS | X-ray | 1.86 | C/D | 686-698 | [»] | |
4ZNT | X-ray | 1.90 | C/D | 686-698 | [»] | |
4ZNU | X-ray | 2.40 | C/D | 686-698 | [»] | |
4ZNV | X-ray | 1.77 | C/D | 686-698 | [»] | |
4ZNW | X-ray | 2.31 | C/D | 686-698 | [»] | |
4ZO1 | X-ray | 3.22 | A | 686-694 | [»] | |
4ZSH | X-ray | 1.80 | B | 686-698 | [»] | |
5APH | X-ray | 1.54 | C | 686-697 | [»] | |
5APJ | X-ray | 2.08 | C | 686-697 | [»] | |
5DI7 | X-ray | 2.24 | C/D | 686-699 | [»] | |
5DID | X-ray | 2.24 | C/D | 686-699 | [»] | |
5DIE | X-ray | 2.24 | C/D | 686-699 | [»] | |
5DIG | X-ray | 2.24 | C/D | 686-699 | [»] | |
5DK9 | X-ray | 2.28 | C/D | 686-699 | [»] | |
5DKB | X-ray | 2.40 | C/D | 686-699 | [»] | |
5DKE | X-ray | 2.60 | C/D | 686-699 | [»] | |
5DKG | X-ray | 2.15 | C/D | 686-699 | [»] | |
5DKS | X-ray | 2.60 | C/D | 686-699 | [»] | |
5DL4 | X-ray | 2.10 | C/D | 686-699 | [»] | |
5DLR | X-ray | 2.26 | C/D | 686-699 | [»] | |
5DMC | X-ray | 2.40 | C/D | 686-699 | [»] | |
5DMF | X-ray | 2.40 | C/D | 686-699 | [»] | |
5DP0 | X-ray | 2.38 | C/D | 686-699 | [»] | |
5DRJ | X-ray | 2.07 | C/D | 686-699 | [»] | |
5DRM | X-ray | 2.24 | C/D | 686-699 | [»] | |
5DTV | X-ray | 2.29 | C/D | 686-699 | [»] | |
5DU5 | X-ray | 2.19 | C/D | 686-699 | [»] | |
5DUE | X-ray | 2.09 | C/D | 686-699 | [»] | |
5DUG | X-ray | 2.25 | C/D | 686-699 | [»] | |
5DUH | X-ray | 2.24 | C/D | 686-699 | [»] | |
5DVS | X-ray | 2.28 | C/D | 686-699 | [»] | |
5DVV | X-ray | 2.50 | C/D | 686-699 | [»] | |
5DWE | X-ray | 1.92 | C/D | 686-699 | [»] | |
5DWG | X-ray | 2.30 | C/D | 686-699 | [»] | |
5DWI | X-ray | 2.43 | C/D | 686-699 | [»] | |
5DWJ | X-ray | 2.00 | C/D | 686-699 | [»] | |
5DX3 | X-ray | 2.09 | C/D | 687-697 | [»] | |
5DXB | X-ray | 2.08 | D/E | 687-697 | [»] | |
5DXE | X-ray | 1.50 | C/D | 687-697 | [»] | |
5DXG | X-ray | 1.86 | C/D | 687-697 | [»] | |
5DXK | X-ray | 2.23 | C/D | 686-699 | [»] | |
5DXM | X-ray | 2.37 | C/D | 686-699 | [»] | |
5DXP | X-ray | 2.20 | C/D | 686-699 | [»] | |
5DXQ | X-ray | 2.40 | C/D | 686-699 | [»] | |
5DXR | X-ray | 2.28 | C/D | 686-699 | [»] | |
5DY8 | X-ray | 2.03 | C/D | 686-699 | [»] | |
5DYB | X-ray | 2.27 | C/D | 686-699 | [»] | |
5DYD | X-ray | 2.48 | C/D | 686-699 | [»] | |
5DZ0 | X-ray | 2.24 | C/D | 686-699 | [»] | |
5DZ1 | X-ray | 2.20 | C/D | 686-699 | [»] | |
5DZ3 | X-ray | 2.15 | C/D | 686-699 | [»] | |
5DZH | X-ray | 2.11 | C/D | 686-699 | [»] | |
5DZI | X-ray | 1.90 | C/D | 686-699 | [»] | |
5E0W | X-ray | 2.00 | C/D | 686-699 | [»] | |
5E0X | X-ray | 2.01 | C/D | 686-699 | [»] | |
5E14 | X-ray | 2.22 | C/D | 686-699 | [»] | |
5E15 | X-ray | 2.10 | C/D | 686-699 | [»] | |
5E19 | X-ray | 2.24 | C/D | 686-699 | [»] | |
5E1C | X-ray | 1.98 | C/D | 686-699 | [»] | |
5EC9 | X-ray | 2.30 | B | 686-696 | [»] | |
5EGV | X-ray | 2.86 | C/D | 686-699 | [»] | |
5EHJ | X-ray | 2.50 | C/D | 686-699 | [»] | |
5EI1 | X-ray | 2.40 | C/D | 686-699 | [»] | |
5EIT | X-ray | 2.68 | C/D | 686-699 | [»] | |
5G3J | X-ray | 2.40 | B | 740-753 | [»] | |
5G42 | X-ray | 1.72 | C | 688-697 | [»] | |
5G43 | X-ray | 2.58 | C | 686-697 | [»] | |
5G44 | X-ray | 1.84 | C | 686-697 | [»] | |
5G45 | X-ray | 2.07 | C | 688-697 | [»] | |
5G46 | X-ray | 1.76 | C | 688-697 | [»] | |
5G5W | X-ray | 2.20 | B | 740-753 | [»] | |
5H1E | X-ray | 2.60 | C | 740-752 | [»] | |
5HYR | X-ray | 2.27 | F/G | 687-697 | [»] | |
5I4V | X-ray | 2.61 | A/B/E/F | 687-699 | [»] | |
5IAW | X-ray | 2.58 | C/D | 742-751 | [»] | |
5ICK | X-ray | 2.47 | C/D | 742-752 | [»] | |
5KCC | X-ray | 2.39 | C/D | 686-699 | [»] | |
5KCD | X-ray | 1.82 | C/D | 686-699 | [»] | |
5KCE | X-ray | 1.85 | C/D | 686-698 | [»] | |
C/D | 687-696 | [»] | ||||
5KCF | X-ray | 2.07 | C/D | 686-699 | [»] | |
5KCT | X-ray | 1.60 | C/D | 686-699 | [»] | |
5KCU | X-ray | 2.03 | C/D | 686-699 | [»] | |
5KCW | X-ray | 1.91 | C/D | 686-699 | [»] | |
5KD9 | X-ray | 1.78 | C/D | 686-699 | [»] | |
5KR9 | X-ray | 2.25 | C/D | 686-699 | [»] | |
5KRA | X-ray | 2.40 | C/D/G/H | 686-699 | [»] | |
5KRC | X-ray | 2.40 | C/D | 686-699 | [»] | |
5KRF | X-ray | 2.19 | C/D | 686-699 | [»] | |
5KRH | X-ray | 2.24 | C/D | 686-699 | [»] | |
5KRI | X-ray | 2.25 | C/D | 686-699 | [»] | |
5KRJ | X-ray | 2.70 | C/D | 686-699 | [»] | |
5KRK | X-ray | 2.39 | C/D | 686-699 | [»] | |
5KRL | X-ray | 2.40 | C/D | 686-699 | [»] | |
5KRM | X-ray | 2.24 | C/D | 686-699 | [»] | |
5KRO | X-ray | 2.10 | C/D | 686-699 | [»] | |
5L11 | X-ray | 1.85 | C | 740-753 | [»] | |
5LGA | X-ray | 2.50 | B | 686-698 | [»] | |
5LYQ | X-ray | 2.17 | B | 686-698 | [»] | |
5MK4 | X-ray | 2.00 | B/D | 686-696 | [»] | |
5NFP | X-ray | 2.10 | B | 740-753 | [»] | |
5NFT | X-ray | 2.30 | B | 740-753 | [»] | |
5NI5 | X-ray | 2.30 | C | 684-698 | [»] | |
5NI7 | X-ray | 2.45 | C | 684-698 | [»] | |
5NI8 | X-ray | 1.94 | C | 684-698 | [»] | |
5NIB | X-ray | 1.82 | C | 684-698 | [»] | |
5Q17 | X-ray | 2.10 | B | 741-752 | [»] | |
5SYZ | X-ray | 1.93 | C | 740-754 | [»] | |
5T1Z | X-ray | 2.10 | C/D | 686-698 | [»] | |
5TLD | X-ray | 2.38 | C/D | 686-698 | [»] | |
5TLF | X-ray | 2.20 | C/D | 686-698 | [»] | |
5TLG | X-ray | 2.23 | C/D | 686-698 | [»] | |
5TLL | X-ray | 2.42 | C/D | 686-698 | [»] | |
5TLM | X-ray | 2.50 | C/D | 686-698 | [»] | |
5TLO | X-ray | 2.28 | C/D | 686-698 | [»] | |
5TLP | X-ray | 2.08 | C/D | 686-698 | [»] | |
5TLT | X-ray | 1.90 | C/D | 686-698 | [»] | |
5TLU | X-ray | 2.22 | C/D | 686-698 | [»] | |
5TLV | X-ray | 2.32 | C/D | 686-698 | [»] | |
5TLX | X-ray | 2.10 | C/D | 686-698 | [»] | |
5TLY | X-ray | 2.14 | C/D | 686-698 | [»] | |
5TM1 | X-ray | 2.23 | C/D | 686-698 | [»] | |
5TM2 | X-ray | 2.60 | C/D | 686-698 | [»] | |
5TM3 | X-ray | 2.19 | C/D | 686-698 | [»] | |
5TM4 | X-ray | 2.25 | C/D | 686-698 | [»] | |
5TM5 | X-ray | 2.24 | C/D | 686-698 | [»] | |
5TM6 | X-ray | 2.54 | C/D | 686-698 | [»] | |
5TM7 | X-ray | 2.40 | C/D | 686-698 | [»] | |
5TM8 | X-ray | 1.99 | C/D | 686-698 | [»] | |
5TM9 | X-ray | 2.50 | C/D | 686-698 | [»] | |
5TML | X-ray | 2.25 | C/D | 686-698 | [»] | |
5TMM | X-ray | 2.20 | C/D | 686-698 | [»] | |
5TMO | X-ray | 2.17 | C/D | 686-698 | [»] | |
5TMQ | X-ray | 2.24 | C/D | 686-698 | [»] | |
5TMR | X-ray | 2.30 | C/D | 686-698 | [»] | |
5TMS | X-ray | 2.24 | C/D | 686-698 | [»] | |
5TMT | X-ray | 2.05 | C/D | 686-698 | [»] | |
5TMU | X-ray | 2.43 | C/D | 686-698 | [»] | |
5TMV | X-ray | 2.38 | C/D | 686-698 | [»] | |
5TMW | X-ray | 2.29 | C/D | 686-698 | [»] | |
5TMZ | X-ray | 2.21 | C/D | 686-698 | [»] | |
5TN1 | X-ray | 2.06 | C/D | 686-698 | [»] | |
5TN3 | X-ray | 2.54 | C/D | 686-698 | [»] | |
5TN4 | X-ray | 1.86 | C/D | 686-698 | [»] | |
5TN5 | X-ray | 1.89 | C/D | 686-698 | [»] | |
5TN6 | X-ray | 2.09 | C/D | 686-698 | [»] | |
5TN7 | X-ray | 2.24 | C/D | 686-698 | [»] | |
5TN8 | X-ray | 2.65 | C/D | 686-698 | [»] | |
5U2D | X-ray | 1.86 | C/D | 686-698 | [»] | |
5UAN | X-ray | 3.51 | C/D | 687-696 | [»] | |
5VB3 | X-ray | 1.95 | A | 685-697 | [»] | |
5VB5 | X-ray | 2.23 | A | 685-697 | [»] | |
5VB6 | X-ray | 2.04 | A | 685-697 | [»] | |
5VB7 | X-ray | 2.33 | A | 685-697 | [»] | |
5VQK | X-ray | 3.10 | A | 685-697 | [»] | |
5VQL | X-ray | 2.70 | A | 685-697 | [»] | |
5WGQ | X-ray | 2.30 | E/F | 687-697 | [»] | |
5WZX | X-ray | 2.95 | C/D | 741-752 | [»] | |
5XPL | X-ray | 2.05 | C | 740-752 | [»] | |
5Y1J | X-ray | 2.00 | U | 742-751 | [»] | |
5Y49 | X-ray | 2.40 | D/E | 741-751 | [»] | |
5YP5 | X-ray | 2.65 | B | 688-695 | [»] | |
5YXB | X-ray | 2.95 | B | 741-751 | [»] | |
5YXD | X-ray | 2.98 | B | 741-751 | [»] | |
5YXJ | X-ray | 2.62 | C/D | 741-751 | [»] | |
5YXL | X-ray | 2.24 | B/D | 743-750 | [»] | |
5Z12 | X-ray | 2.75 | F/I | 687-695 | [»] | |
H/J | 687-692 | [»] | ||||
6CZN | X-ray | 2.50 | C/D | 686-698 | [»] | |
6D0F | X-ray | 2.50 | C/D | 687-696 | [»] | |
6EL6 | X-ray | 2.40 | B | 740-753 | [»] | |
6EL7 | X-ray | 2.18 | B | 740-753 | [»] | |
6EL9 | X-ray | 2.19 | B | 740-753 | [»] | |
6ESN | X-ray | 1.84 | C | 686-697 | [»] | |
6KKB | X-ray | 1.70 | D | 741-751 | [»] | |
6KKE | X-ray | 2.58 | C | 741-751 | [»] | |
6KNU | X-ray | 2.70 | C | 741-751 | [»] | |
6KNV | X-ray | 2.80 | C | 741-751 | [»] | |
6KNW | X-ray | 2.67 | C | 741-751 | [»] | |
6LB4 | X-ray | 1.50 | B | 686-698 | [»] | |
6LB5 | X-ray | 2.40 | B/D | 686-698 | [»] | |
6LB6 | X-ray | 2.40 | B | 686-698 | [»] | |
6LIT | X-ray | 2.00 | D/E | 686-696 | [»] | |
6OQX | X-ray | 2.00 | C | 740-754 | [»] | |
6OQY | X-ray | 2.23 | C | 740-754 | [»] | |
6OR1 | X-ray | 2.17 | C | 740-754 | [»] | |
6R7A | X-ray | 2.13 | C | 684-698 | [»] | |
6R7J | X-ray | 1.84 | C | 684-698 | [»] | |
6R7K | X-ray | 1.54 | C | 684-698 | [»] | |
6SJM | X-ray | 2.52 | B | 686-699 | [»] | |
6STI | X-ray | 1.89 | B | 686-698 | [»] | |
6VC2 | X-ray | 1.70 | C | 740-754 | [»] | |
6VIF | X-ray | 2.26 | B | 740-753 | [»] | |
7A77 | X-ray | 1.50 | B | 686-699 | [»] | |
7A78 | X-ray | 1.72 | B | 686-699 | [»] | |
7A79 | X-ray | 2.05 | C/D | 686-699 | [»] | |
7B88 | X-ray | 2.38 | B | 686-699 | [»] | |
7B9O | X-ray | 2.05 | C | 686-699 | [»] | |
7D42 | X-ray | 2.70 | B | 740-753 | [»] | |
7JHD | X-ray | 2.40 | C/D | 686-698 | [»] | |
7KCO | X-ray | 1.86 | C/D | 685-697 | [»] | |
7NEL | X-ray | 1.45 | C/D | 686-699 | [»] | |
7NFB | X-ray | 1.33 | C/D | 686-699 | [»] | |
AlphaFoldDBi | Q15596 | |||||
SASBDBi | Q15596 | |||||
SMRi | Q15596 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115761, 91 interactors |
ComplexPortali | CPX-513, RXRalpha-NCOA2 activated retinoic acid receptor complex CPX-5156, ERalpha-NCOA2 activated estrogen receptor complex CPX-666, RARalpha-NCOA2 activated retinoic acid receptor complex CPX-702, PPARgamma-NCOA2 activated nuclear receptor complex CPX-816, RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex |
CORUMi | Q15596 |
DIPi | DIP-5997N |
ELMi | Q15596 |
IntActi | Q15596, 54 interactors |
MINTi | Q15596 |
STRINGi | 9606.ENSP00000399968 |
Chemistry databases
BindingDBi | Q15596 |
DrugBanki | DB08175, (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID DB07678, (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL DB07707, (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL DB06871, 17-METHYL-17-ALPHA-DIHYDROEQUILENIN DB08773, 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol DB08402, 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID DB08398, 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine DB07863, 2-chloro-5-nitro-N-phenylbenzamide DB07708, 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL DB07712, 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL DB06898, 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol DB08048, 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL DB08595, 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07195, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07086, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07087, 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB08047, 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol DB08320, DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE DB00255, Diethylstilbestrol DB07932, dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB01645, Genistein DB02998, Metribolone DB07080, TO-901317 DB08601, Tributyltin |
PTM databases
GlyGeni | Q15596, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q15596 |
PhosphoSitePlusi | Q15596 |
Genetic variation databases
BioMutai | NCOA2 |
DMDMi | 13626594 |
Proteomic databases
EPDi | Q15596 |
jPOSTi | Q15596 |
MassIVEi | Q15596 |
MaxQBi | Q15596 |
PaxDbi | Q15596 |
PeptideAtlasi | Q15596 |
PRIDEi | Q15596 |
ProteomicsDBi | 60649 |
Protocols and materials databases
Antibodypediai | 6252, 301 antibodies from 31 providers |
DNASUi | 10499 |
Genome annotation databases
Ensembli | ENST00000452400.7; ENSP00000399968.2; ENSG00000140396.13 |
GeneIDi | 10499 |
KEGGi | hsa:10499 |
MANE-Selecti | ENST00000452400.7; ENSP00000399968.2; NM_006540.4; NP_006531.1 |
UCSCi | uc003xyn.2, human |
Organism-specific databases
CTDi | 10499 |
DisGeNETi | 10499 |
GeneCardsi | NCOA2 |
HGNCi | HGNC:7669, NCOA2 |
HPAi | ENSG00000140396, Low tissue specificity |
MIMi | 601993, gene |
neXtProti | NX_Q15596 |
OpenTargetsi | ENSG00000140396 |
PharmGKBi | PA31471 |
VEuPathDBi | HostDB:ENSG00000140396 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00950000183021 |
HOGENOMi | CLU_001988_0_0_1 |
InParanoidi | Q15596 |
OMAi | DSNMPPV |
OrthoDBi | 59971at2759 |
PhylomeDBi | Q15596 |
TreeFami | TF332652 |
Enzyme and pathway databases
PathwayCommonsi | Q15596 |
Reactomei | R-HSA-1368082, RORA activates gene expression R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-159418, Recycling of bile acids and salts R-HSA-192105, Synthesis of bile acids and bile salts R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-1989781, PPARA activates gene expression R-HSA-211976, Endogenous sterols R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-3214847, HATs acetylate histones R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9707564, Cytoprotection by HMOX1 R-HSA-9707616, Heme signaling |
SignaLinki | Q15596 |
SIGNORi | Q15596 |
Miscellaneous databases
BioGRID-ORCSi | 10499, 25 hits in 1096 CRISPR screens |
ChiTaRSi | NCOA2, human |
EvolutionaryTracei | Q15596 |
GeneWikii | Nuclear_receptor_coactivator_2 |
GenomeRNAii | 10499 |
Pharosi | Q15596, Tbio |
PROi | PR:Q15596 |
RNActi | Q15596, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140396, Expressed in epithelium of mammary gland and 249 other tissues |
ExpressionAtlasi | Q15596, baseline and differential |
Genevisiblei | Q15596, HS |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
DisProti | DP01880 |
Gene3Di | 4.10.280.10, 1 hit 6.10.140.20, 1 hit |
IDEALi | IID00082 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032565, DUF4927 IPR036638, HLH_DNA-bd_sf IPR010011, NCO_DUF1518 IPR028822, NCOA2 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 1 hit PTHR10684:SF2, PTHR10684:SF2, 1 hit |
Pfami | View protein in Pfam PF07469, DUF1518, 1 hit PF16279, DUF4927, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 1 hit |
SMARTi | View protein in SMART SM01151, DUF1518, 1 hit SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NCOA2_HUMAN | |
Accessioni | Q15596Primary (citable) accession number: Q15596 Secondary accession number(s): Q14CD2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | May 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 231 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families