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UniProtKB - Q15583 (TGIF1_HUMAN)

Entry version 218 (25 May 2022)
Sequence version 3 (25 Nov 2008)
Previous versions | rss
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Protein

Homeobox protein TGIF1

Gene

TGIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi164 – 226Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15583

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15583

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15583

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein TGIF1
Alternative name(s):
5'-TG-3'-interacting factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TGIF1
Synonyms:TGIF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11776, TGIF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602630, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15583

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000177426

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Holoprosencephaly 4 (HPE4)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_009961157S → C in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909066Ensembl.1
Natural variantiVAR_009962192P → R in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909067Ensembl.1
Natural variantiVAR_023803236Q → L in HPE4. 1 PublicationCorresponds to variant dbSNP:rs28939693Ensembl.1
Natural variantiVAR_009963280T → A in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909068Ensembl.1
Natural variantiVAR_009964291S → F in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909069Ensembl.1

Keywords - Diseasei

Disease variant, Holoprosencephaly

Organism-specific databases

DisGeNET

More...DisGeNETi		7050

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		TGIF1

MalaCards human disease database

More...MalaCardsi		TGIF1
MIMi142946, phenotype

Open Targets

More...OpenTargetsi		ENSG00000177426

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		93925, Alobar holoprosencephaly
93924, Lobar holoprosencephaly
280200, Microform holoprosencephaly
93926, Midline interhemispheric variant of holoprosencephaly
220386, Semilobar holoprosencephaly
280195, Septopreoptic holoprosencephaly

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36489

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15583, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TGIF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274200

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000493181 – 401Homeobox protein TGIF1Add BLAST401

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15583

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15583

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15583

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15583

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15583

PeptideAtlas

More...PeptideAtlasi		Q15583

PRoteomics IDEntifications database

More...PRIDEi		Q15583

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60646 [Q15583-1]
60647 [Q15583-2]
60648 [Q15583-3]
958

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15583

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15583

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000177426, Expressed in left coronary artery and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15583, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15583, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000177426, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMAD2 (PubMed:10835638).

Interacts with CTBP, SMAD3 and HDAC1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112908, 29 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15583

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q15583

Protein interaction database and analysis system

More...IntActi		Q15583, 22 interactors

Molecular INTeraction database

More...MINTi		Q15583

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000327959

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15583, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1401
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q15583

Biological Magnetic Resonance Data Bank

More...BMRBi		Q15583

Small Angle Scattering Biological Data Bank

More...SASBDBi		Q15583

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15583

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15583

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni78 – 127DisorderedSequence analysisAdd BLAST50
Regioni139 – 170DisorderedSequence analysisAdd BLAST32
Regioni274 – 293DisorderedSequence analysisAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi153 – 157CTBP-binding motif5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0773, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155230

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15583

Identification of Orthologs from Complete Genome Data

More...OMAi		FPLCQSV

Database of Orthologous Groups

More...OrthoDBi		1573375at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15583

TreeFam database of animal gene trees

More...TreeFami		TF318093

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR008422, Homeobox_KN_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05920, Homeobox_KN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15583-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLAQSRVSA GVGSPHCSGS GGGGSDSFPW PASHPGNPQC SFSTAFLASP 
        60         70         80         90        100
RLSRGTLAYL PPAPWSSLAT PSALLGSSCA PPPPPARCPQ PRALSPELGT 
       110        120        130        140        150
KAGPRRPHRW ELPRSPSQGA QGPAPRRRLL ETMKGIVAAS GSETEDEDSM 
       160        170        180        190        200
DIPLDLSSSA GSGKRRRRGN LPKESVQILR DWLYEHRYNA YPSEQEKALL 
       210        220        230        240        250
SQQTHLSTLQ VCNWFINARR RLLPDMLRKD GKDPNQFTIS RRGAKISETS 
       260        270        280        290        300
SVESVMGIKN FMPALEETPF HSCTAGPNPT LGRPLSPKPS SPGSVLARPS 
       310        320        330        340        350
VICHTTVTAL KDVPFSLCQS VGVGQNTDIQ QIAAKNFTDT SLMYPEDTCK 
       360        370        380        390        400
SGPSTNTQSG LFNTPPPTPP DLNQDFSGFQ LLVDVALKRA AEMELQAKLT 

A
Length:401
Mass (Da):43,013
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D9C76AFB37A29F0
GO
Isoform 2 (identifier: Q15583-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.
     130-133: LETM → MKGK

Show »
Length:272
Mass (Da):29,737
Checksum:i948D1F689996E84E
GO
Isoform 3 (identifier: Q15583-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     116-134: PSQGAQGPAPRRRLLETMK → MTCSGKSCALARSSLTSSQ

Show »
Length:286
Mass (Da):31,064
Checksum:i39EA173EECBFD391
GO
Isoform 4 (identifier: Q15583-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-149: Missing.

Show »
Length:252
Mass (Da):27,715
Checksum:iA3426BEBB9753C87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VUY0F8VUY0_HUMAN
Homeobox protein TGIF1
TGIF1
219Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVS9F8VVS9_HUMAN
Homeobox protein TGIF1
TGIF1
245Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VW34F8VW34_HUMAN
Homeobox protein TGIF1
TGIF1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXG3F8VXG3_HUMAN
Homeobox protein TGIF1
TGIF1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VX54F8VX54_HUMAN
Homeobox protein TGIF1
TGIF1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYL4F8VYL4_HUMAN
Homeobox protein TGIF1
TGIF1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZH2F8VZH2_HUMAN
Homeobox protein TGIF1
TGIF1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWK5F8VWK5_HUMAN
Homeobox protein TGIF1
TGIF1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1J9F8W1J9_HUMAN
Homeobox protein TGIF1
TGIF1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS32J3KS32_HUMAN
Homeobox protein TGIF1
TGIF1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96P → Q in AAH31268 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009961157S → C in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909066Ensembl.1
Natural variantiVAR_009962192P → R in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909067Ensembl.1
Natural variantiVAR_023803236Q → L in HPE4. 1 PublicationCorresponds to variant dbSNP:rs28939693Ensembl.1
Natural variantiVAR_009963280T → A in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909068Ensembl.1
Natural variantiVAR_047363289P → S. Corresponds to variant dbSNP:rs11571512Ensembl.1
Natural variantiVAR_009964291S → F in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909069Ensembl.1
Natural variantiVAR_020151292P → L. Corresponds to variant dbSNP:rs2229333Ensembl.1
Natural variantiVAR_061268292P → S2 PublicationsCorresponds to variant dbSNP:rs4468717Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468481 – 149Missing in isoform 4. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_0130201 – 129Missing in isoform 2. 4 PublicationsAdd BLAST129
Alternative sequenceiVSP_0431081 – 115Missing in isoform 3. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_043109116 – 134PSQGA…LETMK → MTCSGKSCALARSSLTSSQ in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_013021130 – 133LETM → MKGK in isoform 2. 4 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X89750 mRNA Translation: CAA61897.1
AF179900 mRNA Translation: AAF81643.1
CR450333 mRNA Translation: CAG29329.1
AK291112 mRNA Translation: BAF83801.1
AP001025 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01672.1
BC000814 mRNA Translation: AAH00814.1
BC031268 mRNA Translation: AAH31268.1
BE296707 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11832.1 [Q15583-3]
CCDS11833.1 [Q15583-2]
CCDS11834.1 [Q15583-4]
CCDS11835.1 [Q15583-4]

NCBI Reference Sequences

More...RefSeqi		NP_001265611.1, NM_001278682.1
NP_001265613.1, NM_001278684.1 [Q15583-2]
NP_001265615.1, NM_001278686.1 [Q15583-4]
NP_003235.1, NM_003244.3 [Q15583-2]
NP_733796.2, NM_170695.3 [Q15583-4]
NP_775299.1, NM_173207.2 [Q15583-3]
NP_775300.1, NM_173208.2 [Q15583-2]
NP_775301.1, NM_173209.2 [Q15583-4]
NP_775302.1, NM_173210.2 [Q15583-4]
NP_775303.1, NM_173211.1 [Q15583-4]
NP_777480.1, NM_174886.2 [Q15583-4]
XP_011524037.1, XM_011525735.2
XP_016881447.1, XM_017025958.1 [Q15583-2]
XP_016881448.1, XM_017025959.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000330513.10; ENSP00000327959.6; ENSG00000177426.22 [Q15583-4]
ENST00000343820.10; ENSP00000339631.6; ENSG00000177426.22 [Q15583-2]
ENST00000345133.9; ENSP00000343969.5; ENSG00000177426.22 [Q15583-4]
ENST00000400167.6; ENSP00000383031.2; ENSG00000177426.22 [Q15583-4]
ENST00000401449.5; ENSP00000385206.1; ENSG00000177426.22 [Q15583-4]
ENST00000405385.7; ENSP00000384970.2; ENSG00000177426.22 [Q15583-4]
ENST00000407501.6; ENSP00000384133.2; ENSG00000177426.22 [Q15583-2]
ENST00000472042.1; ENSP00000449501.1; ENSG00000177426.22 [Q15583-4]
ENST00000548489.6; ENSP00000447747.2; ENSG00000177426.22 [Q15583-4]
ENST00000551541.5; ENSP00000450025.1; ENSG00000177426.22 [Q15583-4]
ENST00000618001.4; ENSP00000483499.1; ENSG00000177426.22 [Q15583-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7050

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000343820.10; ENSP00000339631.6; NM_003244.4; NP_003235.1 [Q15583-2]

UCSC genome browser

More...UCSCi		uc002klu.5, human [Q15583-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89750 mRNA Translation: CAA61897.1
AF179900 mRNA Translation: AAF81643.1
CR450333 mRNA Translation: CAG29329.1
AK291112 mRNA Translation: BAF83801.1
AP001025 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01672.1
BC000814 mRNA Translation: AAH00814.1
BC031268 mRNA Translation: AAH31268.1
BE296707 mRNA No translation available.
CCDSiCCDS11832.1 [Q15583-3]
CCDS11833.1 [Q15583-2]
CCDS11834.1 [Q15583-4]
CCDS11835.1 [Q15583-4]
RefSeqiNP_001265611.1, NM_001278682.1
NP_001265613.1, NM_001278684.1 [Q15583-2]
NP_001265615.1, NM_001278686.1 [Q15583-4]
NP_003235.1, NM_003244.3 [Q15583-2]
NP_733796.2, NM_170695.3 [Q15583-4]
NP_775299.1, NM_173207.2 [Q15583-3]
NP_775300.1, NM_173208.2 [Q15583-2]
NP_775301.1, NM_173209.2 [Q15583-4]
NP_775302.1, NM_173210.2 [Q15583-4]
NP_775303.1, NM_173211.1 [Q15583-4]
NP_777480.1, NM_174886.2 [Q15583-4]
XP_011524037.1, XM_011525735.2
XP_016881447.1, XM_017025958.1 [Q15583-2]
XP_016881448.1, XM_017025959.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LK2NMR-A171-248[»]
6FQPX-ray2.42A/B150-248[»]
6FQQX-ray3.25A/B/D/E161-229[»]
AlphaFoldDBiQ15583
BMRBiQ15583
SASBDBiQ15583
SMRiQ15583
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112908, 29 interactors
CORUMiQ15583
ELMiQ15583
IntActiQ15583, 22 interactors
MINTiQ15583
STRINGi9606.ENSP00000327959

PTM databases

iPTMnetiQ15583
PhosphoSitePlusiQ15583

Genetic variation databases

BioMutaiTGIF1
DMDMi215274200

Proteomic databases

EPDiQ15583
jPOSTiQ15583
MassIVEiQ15583
MaxQBiQ15583
PaxDbiQ15583
PeptideAtlasiQ15583
PRIDEiQ15583
ProteomicsDBi60646 [Q15583-1]
60647 [Q15583-2]
60648 [Q15583-3]
958

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q15583, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3890, 381 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		7050

Genome annotation databases

EnsembliENST00000330513.10; ENSP00000327959.6; ENSG00000177426.22 [Q15583-4]
ENST00000343820.10; ENSP00000339631.6; ENSG00000177426.22 [Q15583-2]
ENST00000345133.9; ENSP00000343969.5; ENSG00000177426.22 [Q15583-4]
ENST00000400167.6; ENSP00000383031.2; ENSG00000177426.22 [Q15583-4]
ENST00000401449.5; ENSP00000385206.1; ENSG00000177426.22 [Q15583-4]
ENST00000405385.7; ENSP00000384970.2; ENSG00000177426.22 [Q15583-4]
ENST00000407501.6; ENSP00000384133.2; ENSG00000177426.22 [Q15583-2]
ENST00000472042.1; ENSP00000449501.1; ENSG00000177426.22 [Q15583-4]
ENST00000548489.6; ENSP00000447747.2; ENSG00000177426.22 [Q15583-4]
ENST00000551541.5; ENSP00000450025.1; ENSG00000177426.22 [Q15583-4]
ENST00000618001.4; ENSP00000483499.1; ENSG00000177426.22 [Q15583-3]
GeneIDi7050
KEGGihsa:7050
MANE-SelectiENST00000343820.10; ENSP00000339631.6; NM_003244.4; NP_003235.1 [Q15583-2]
UCSCiuc002klu.5, human [Q15583-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7050
DisGeNETi7050

GeneCards: human genes, protein and diseases

More...GeneCardsi		TGIF1
GeneReviewsiTGIF1
HGNCiHGNC:11776, TGIF1
HPAiENSG00000177426, Low tissue specificity
MalaCardsiTGIF1
MIMi142946, phenotype
602630, gene
neXtProtiNX_Q15583
OpenTargetsiENSG00000177426
Orphaneti93925, Alobar holoprosencephaly
93924, Lobar holoprosencephaly
280200, Microform holoprosencephaly
93926, Midline interhemispheric variant of holoprosencephaly
220386, Semilobar holoprosencephaly
280195, Septopreoptic holoprosencephaly
PharmGKBiPA36489
VEuPathDBiHostDB:ENSG00000177426

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0773, Eukaryota
GeneTreeiENSGT00940000155230
InParanoidiQ15583
OMAiFPLCQSV
OrthoDBi1573375at2759
PhylomeDBiQ15583
TreeFamiTF318093

Enzyme and pathway databases

PathwayCommonsiQ15583
ReactomeiR-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SignaLinkiQ15583
SIGNORiQ15583

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7050, 71 hits in 1101 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TGIF1, human
EvolutionaryTraceiQ15583

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Homeobox_protein_TGIF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7050
PharosiQ15583, Tbio

Protein Ontology

More...PROi		PR:Q15583
RNActiQ15583, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000177426, Expressed in left coronary artery and 222 other tissues
ExpressionAtlasiQ15583, baseline and differential
GenevisibleiQ15583, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR008422, Homeobox_KN_domain
PfamiView protein in Pfam
PF05920, Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGIF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15583
Secondary accession number(s): A6NE42
, A6NLU7, F8VZB6, Q6ICR0, Q8N5X9, Q9NRS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: May 25, 2022
This is version 218 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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