TGIF1

Functionⁱ

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	164 – 226	Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST		63

GO - Molecular functionⁱ

co-SMAD binding Source: Ensembl
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 8537382
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 10764806
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10764806
transcription corepressor activity
Source: ProtInc
Traceable author statementⁱ
- 10764806

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to growth factor stimulus Source: Ensembl
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 8537382
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 10764806
response to drug Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SignaLinkⁱ	Q15583
SIGNORⁱ	Q15583

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein TGIF1 Alternative name(s): 5'-TG-3'-interacting factor 1
Gene namesⁱ	Name:TGIF1 Synonyms:TGIF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177426.20
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11776 TGIF1
MIMⁱ	602630 gene
neXtProtⁱ	NX_Q15583

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Holoprosencephaly 4 (HPE4)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.

Keywords - Diseaseⁱ

Disease mutation, Holoprosencephaly

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7050
GeneReviewsⁱ	TGIF1
MalaCards human disease database More...MalaCardsⁱ	TGIF1
MIMⁱ	142946 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000177426
Orphanetⁱ	93925 Alobar holoprosencephaly 93924 Lobar holoprosencephaly 280200 Microform holoprosencephaly 93926 Midline interhemispheric variant of holoprosencephaly 220386 Semilobar holoprosencephaly 280195 Septopreoptic holoprosencephaly
PharmGKBⁱ	PA36489

Polymorphism and mutation databases

BioMutaⁱ	TGIF1
DMDMⁱ	215274200

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049318	1 – 401	Homeobox protein TGIF1Add BLAST		401

Proteomic databases

EPDⁱ	Q15583
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15583
PaxDbⁱ	Q15583
PeptideAtlas More...PeptideAtlasⁱ	Q15583
PRIDEⁱ	Q15583
ProteomicsDBⁱ	60646 60647 [Q15583-2] 60648 [Q15583-3]

PTM databases

iPTMnetⁱ	Q15583
PhosphoSitePlusⁱ	Q15583

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177426 Expressed in 208 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_TGIF1
ExpressionAtlasⁱ	Q15583 baseline and differential
Genevisibleⁱ	Q15583 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA062160

HPAⁱ

HPA062160

Interactionⁱ

Subunit structureⁱ

Interacts with CTBP, SMAD2, SMAD3 and HDAC1.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AXIN1	O15169	4	EBI-714215,EBI-710484
Axin1	O35625	2	EBI-714215,EBI-2365912	From Mus musculus.
AXIN2	Q9Y2T1	5	EBI-714215,EBI-4400025
Axin2	O88566	3	EBI-714215,EBI-7690990	From Mus musculus.
CTBP1	Q13363-2	3	EBI-12691451,EBI-10171858
CTBP2	P56545	5	EBI-714215,EBI-741533
LGALS8	O00214	10	EBI-714215,EBI-740058
MDFI	Q99750	4	EBI-714215,EBI-724076
PML	P29590	3	EBI-714215,EBI-295890

GO - Molecular functionⁱ

co-SMAD binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112908, 22 interactors
CORUMⁱ	Q15583
ELMⁱ	Q15583
IntActⁱ	Q15583, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q15583
STRINGⁱ	9606.ENSP00000327959

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	173 – 185	Combined sources	13
Turnⁱ	186 – 188	Combined sources	3
Helixⁱ	194 – 204	Combined sources	11
Helixⁱ	208 – 221	Combined sources	14
Helixⁱ	223 – 228	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15583
SMRⁱ	Q15583
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q15583

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	153 – 157	CTBP-binding motif		5

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	165 – 168	Poly-Arg		4

Sequence similaritiesⁱ

Belongs to the TALE/TGIF homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0773 Eukaryota ENOG410XPMQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074260
HOGENOMⁱ	HOG000232039
HOVERGENⁱ	HBG001143
InParanoidⁱ	Q15583
KEGG Orthology (KO) More...KOⁱ	K19383
OMAⁱ	APFHFCQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GOO
PhylomeDBⁱ	Q15583
TreeFamⁱ	TF318093

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR008422 Homeobox_KN_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05920 Homeobox_KN, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS50071 HOMEOBOX_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15583-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLAQSRVSA GVGSPHCSGS GGGGSDSFPW PASHPGNPQC SFSTAFLASP 
        60         70         80         90        100
RLSRGTLAYL PPAPWSSLAT PSALLGSSCA PPPPPARCPQ PRALSPELGT 
       110        120        130        140        150
KAGPRRPHRW ELPRSPSQGA QGPAPRRRLL ETMKGIVAAS GSETEDEDSM 
       160        170        180        190        200
DIPLDLSSSA GSGKRRRRGN LPKESVQILR DWLYEHRYNA YPSEQEKALL 
       210        220        230        240        250
SQQTHLSTLQ VCNWFINARR RLLPDMLRKD GKDPNQFTIS RRGAKISETS 
       260        270        280        290        300
SVESVMGIKN FMPALEETPF HSCTAGPNPT LGRPLSPKPS SPGSVLARPS 
       310        320        330        340        350
VICHTTVTAL KDVPFSLCQS VGVGQNTDIQ QIAAKNFTDT SLMYPEDTCK 
       360        370        380        390        400
SGPSTNTQSG LFNTPPPTPP DLNQDFSGFQ LLVDVALKRA AEMELQAKLT 

A

Length:401

Mass (Da):43,013

Last modified:November 25, 2008 - v3

Checksum:ⁱ4D9C76AFB37A29F0

GO

Isoform 2 (identifier: Q15583-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-129: Missing.
130-133: LETM → MKGK

« Hide

        10         20         30         40         50
MKGKKGIVAA SGSETEDEDS MDIPLDLSSS AGSGKRRRRG NLPKESVQIL 
        60         70         80         90        100
RDWLYEHRYN AYPSEQEKAL LSQQTHLSTL QVCNWFINAR RRLLPDMLRK 
       110        120        130        140        150
DGKDPNQFTI SRRGAKISET SSVESVMGIK NFMPALEETP FHSCTAGPNP 
       160        170        180        190        200
TLGRPLSPKP SSPGSVLARP SVICHTTVTA LKDVPFSLCQ SVGVGQNTDI 
       210        220        230        240        250
QQIAAKNFTD TSLMYPEDTC KSGPSTNTQS GLFNTPPPTP PDLNQDFSGF 
       260        270 
QLLVDVALKR AAEMELQAKL TA

Show »

Length:272

Mass (Da):29,737

Checksum:ⁱ948D1F689996E84E

GO

Isoform 3 (identifier: Q15583-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.
116-134: PSQGAQGPAPRRRLLETMK → MTCSGKSCALARSSLTSSQ

« Hide

        10         20         30         40         50
MTCSGKSCAL ARSSLTSSQG IVAASGSETE DEDSMDIPLD LSSSAGSGKR 
        60         70         80         90        100
RRRGNLPKES VQILRDWLYE HRYNAYPSEQ EKALLSQQTH LSTLQVCNWF 
       110        120        130        140        150
INARRRLLPD MLRKDGKDPN QFTISRRGAK ISETSSVESV MGIKNFMPAL 
       160        170        180        190        200
EETPFHSCTA GPNPTLGRPL SPKPSSPGSV LARPSVICHT TVTALKDVPF 
       210        220        230        240        250
SLCQSVGVGQ NTDIQQIAAK NFTDTSLMYP EDTCKSGPST NTQSGLFNTP 
       260        270        280 
PPTPPDLNQD FSGFQLLVDV ALKRAAEMEL QAKLTA

Show »

Length:286

Mass (Da):31,064

Checksum:ⁱ39EA173EECBFD391

GO

Isoform 4 (identifier: Q15583-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-149: Missing.

« Hide

        10         20         30         40         50
MDIPLDLSSS AGSGKRRRRG NLPKESVQIL RDWLYEHRYN AYPSEQEKAL 
        60         70         80         90        100
LSQQTHLSTL QVCNWFINAR RRLLPDMLRK DGKDPNQFTI SRRGAKISET 
       110        120        130        140        150
SSVESVMGIK NFMPALEETP FHSCTAGPNP TLGRPLSPKP SSPGSVLARP 
       160        170        180        190        200
SVICHTTVTA LKDVPFSLCQ SVGVGQNTDI QQIAAKNFTD TSLMYPEDTC 
       210        220        230        240        250
KSGPSTNTQS GLFNTPPPTP PDLNQDFSGF QLLVDVALKR AAEMELQAKL 

TA

Note: No experimental confirmation available.

Show »

Length:252

Mass (Da):27,715

Checksum:ⁱA3426BEBB9753C87

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VUY0	F8VUY0_HUMAN	Homeobox protein TGIF1 Homeobox protein TGIF1	TGIF1	219	Annotation score:
F8VVS9	F8VVS9_HUMAN	Homeobox protein TGIF1 Homeobox protein TGIF1	TGIF1	245	Annotation score:
F8VXG3	F8VXG3_HUMAN	Homeobox protein TGIF1 Homeobox protein TGIF1	TGIF1	91	Annotation score:
F8VX54	F8VX54_HUMAN	Homeobox protein TGIF1 Homeobox protein TGIF1	TGIF1	133	Annotation score:
F8VYL4	F8VYL4_HUMAN	Homeobox protein TGIF1 Homeobox protein TGIF1	TGIF1	118	Annotation score:
F8VW34	F8VW34_HUMAN	Homeobox protein TGIF1 Homeobox protein TGIF1	TGIF1	131	Annotation score:
F8VZH2	F8VZH2_HUMAN	Homeobox protein TGIF1 Homeobox protein TGIF1	TGIF1	137	Annotation score:
F8VWK5	F8VWK5_HUMAN	Homeobox protein TGIF1 Homeobox protein TGIF1	TGIF1	167	Annotation score:
F8W1J9	F8W1J9_HUMAN	Homeobox protein TGIF1 Homeobox protein TGIF1	TGIF1	132	Annotation score:
J3KS32	J3KS32_HUMAN	Homeobox protein TGIF1 Homeobox protein TGIF1	TGIF1	84	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	96	P → Q in AAH31268 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_009961	157	S → C in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909066EnsemblClinVar.	1
Natural variantⁱVAR_009962	192	P → R in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909067EnsemblClinVar.	1
Natural variantⁱVAR_023803	236	Q → L in HPE4. 1 PublicationCorresponds to variant dbSNP:rs28939693Ensembl.	1
Natural variantⁱVAR_009963	280	T → A in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909068EnsemblClinVar.	1
Natural variantⁱVAR_047363	289	P → S. Corresponds to variant dbSNP:rs11571512Ensembl.	1
Natural variantⁱVAR_009964	291	S → F in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909069EnsemblClinVar.	1
Natural variantⁱVAR_020151	292	P → L. Corresponds to variant dbSNP:rs2229333Ensembl.	1
Natural variantⁱVAR_061268	292	P → S2 PublicationsCorresponds to variant dbSNP:rs4468717Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046848	1 – 149	Missing in isoform 4. 1 PublicationAdd BLAST	149
Alternative sequenceⁱVSP_013020	1 – 129	Missing in isoform 2. 4 PublicationsAdd BLAST	129
Alternative sequenceⁱVSP_043108	1 – 115	Missing in isoform 3. 1 PublicationAdd BLAST	115
Alternative sequenceⁱVSP_043109	116 – 134	PSQGA…LETMK → MTCSGKSCALARSSLTSSQ in isoform 3. 1 PublicationAdd BLAST	19
Alternative sequenceⁱVSP_013021	130 – 133	LETM → MKGK in isoform 2. 4 Publications	4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X89750 mRNA Translation: CAA61897.1 AF179900 mRNA Translation: AAF81643.1 CR450333 mRNA Translation: CAG29329.1 AK291112 mRNA Translation: BAF83801.1 AP001025 Genomic DNA No translation available. CH471113 Genomic DNA Translation: EAX01672.1 BC000814 mRNA Translation: AAH00814.1 BC031268 mRNA Translation: AAH31268.1 BE296707 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11832.1 [Q15583-3] CCDS11833.1 [Q15583-2] CCDS11834.1 [Q15583-1] CCDS11835.1 [Q15583-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001265611.1, NM_001278682.1 NP_001265613.1, NM_001278684.1 [Q15583-2] NP_001265615.1, NM_001278686.1 [Q15583-4] NP_003235.1, NM_003244.3 [Q15583-2] NP_733796.2, NM_170695.3 [Q15583-1] NP_775299.1, NM_173207.2 [Q15583-3] NP_775300.1, NM_173208.2 [Q15583-2] NP_775301.1, NM_173209.2 [Q15583-4] NP_775302.1, NM_173210.2 [Q15583-4] NP_775303.1, NM_173211.1 [Q15583-4] NP_777480.1, NM_174886.2 [Q15583-4] XP_011524037.1, XM_011525735.2 [Q15583-4] XP_016881447.1, XM_017025958.1 [Q15583-2] XP_016881448.1, XM_017025959.1 [Q15583-4]
UniGeneⁱ	Hs.373550

Genome annotation databases

Ensemblⁱ	ENST00000330513; ENSP00000327959; ENSG00000177426 [Q15583-1] ENST00000343820; ENSP00000339631; ENSG00000177426 [Q15583-2] ENST00000345133; ENSP00000343969; ENSG00000177426 [Q15583-4] ENST00000400167; ENSP00000383031; ENSG00000177426 [Q15583-4] ENST00000401449; ENSP00000385206; ENSG00000177426 [Q15583-4] ENST00000405385; ENSP00000384970; ENSG00000177426 [Q15583-4] ENST00000407501; ENSP00000384133; ENSG00000177426 [Q15583-2] ENST00000472042; ENSP00000449501; ENSG00000177426 [Q15583-4] ENST00000548489; ENSP00000447747; ENSG00000177426 [Q15583-4] ENST00000551541; ENSP00000450025; ENSG00000177426 [Q15583-4] ENST00000618001; ENSP00000483499; ENSG00000177426 [Q15583-3]
GeneIDⁱ	7050
KEGGⁱ	hsa:7050
UCSC genome browser More...UCSCⁱ	uc002klu.5 human [Q15583-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15583	Homeobox protein TGIF1 (Fragment)		HUMAN		219	UniRef100_Q15583
TGIF1 isoform 1 (Fragment)		PONAB		168
TGIF1 isoform 14 (Fragment)		PANTR		168
Isoform 4 of Homeobox protein TGIF1		HUMAN		252
Homeobox protein TGIF1 (Fragment)		HUMAN		245
+1

Protein	Similar proteins		Species	Score	Length	Source
Q15583	Homeobox protein TGIF1		PANTR		401	UniRef90_Q15583
Homeobox protein TGIF1 (Fragment)		HUMAN		219
TGIF1 isoform 1 (Fragment)		PONAB		168
Uncharacterized protein		PANPA		401
Uncharacterized protein		NOMLE		400
+22
Q15583-2	TGFB induced factor homeobox 1		AILME		275	UniRef90_Q15583-2
Uncharacterized protein		PIG		273
homeobox protein TGIF1 isoform X2		ODORO		272
homeobox protein TGIF1		NEOSC		272
Uncharacterized protein		MACNE		272
+86
Q15583-3	Homeobox protein TGIF1		MYODS		345	UniRef90_Q15583-3
Uncharacterized protein		CANLF		289
Uncharacterized protein		LOXAF		287
TGIF1 isoform 6		PONAB		286
Homeobox protein TGIF1		PANTR		286
+22

Protein	Similar proteins		Species	Score	Length	Source
Q15583	Homeobox protein TGIF1		PANTR		401	UniRef50_Q15583
Homeobox protein TGIF1 (Fragment)		HUMAN		219
TGIF1 isoform 1 (Fragment)		PONAB		168
Uncharacterized protein		PANPA		401
Uncharacterized protein		NOMLE		400
+67
Q15583-2	Isoform 3 of Homeobox protein TGIF1		HUMAN		286	UniRef50_Q15583-3
Homeobox protein TGIF1		MOUSE		272
Homeobox protein AKR		CHICK		269
Homeobox protein TGIF1		MYODS		345
Uncharacterized protein		CANLF		289
+369
Q15583-3	Homeobox protein TGIF1		MOUSE		272	UniRef50_Q15583-3
Homeobox protein AKR		CHICK		269
Homeobox protein TGIF1		MYODS		345
Uncharacterized protein		CANLF		289
Uncharacterized protein		LOXAF		287
+369

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X89750 mRNA Translation: CAA61897.1 AF179900 mRNA Translation: AAF81643.1 CR450333 mRNA Translation: CAG29329.1 AK291112 mRNA Translation: BAF83801.1 AP001025 Genomic DNA No translation available. CH471113 Genomic DNA Translation: EAX01672.1 BC000814 mRNA Translation: AAH00814.1 BC031268 mRNA Translation: AAH31268.1 BE296707 mRNA No translation available.
CCDSⁱ	CCDS11832.1 [Q15583-3] CCDS11833.1 [Q15583-2] CCDS11834.1 [Q15583-1] CCDS11835.1 [Q15583-4]
RefSeqⁱ	NP_001265611.1, NM_001278682.1 NP_001265613.1, NM_001278684.1 [Q15583-2] NP_001265615.1, NM_001278686.1 [Q15583-4] NP_003235.1, NM_003244.3 [Q15583-2] NP_733796.2, NM_170695.3 [Q15583-1] NP_775299.1, NM_173207.2 [Q15583-3] NP_775300.1, NM_173208.2 [Q15583-2] NP_775301.1, NM_173209.2 [Q15583-4] NP_775302.1, NM_173210.2 [Q15583-4] NP_775303.1, NM_173211.1 [Q15583-4] NP_777480.1, NM_174886.2 [Q15583-4] XP_011524037.1, XM_011525735.2 [Q15583-4] XP_016881447.1, XM_017025958.1 [Q15583-2] XP_016881448.1, XM_017025959.1 [Q15583-4]
UniGeneⁱ	Hs.373550

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LK2	NMR	-	A	171-248	[»]
	6FQP	X-ray	2.42	A/B	150-248	[»]
	6FQQ	X-ray	3.25	A/B/D/E	161-229	[»]
ProteinModelPortalⁱ	Q15583
SMRⁱ	Q15583
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112908, 22 interactors
CORUMⁱ	Q15583
ELMⁱ	Q15583
IntActⁱ	Q15583, 14 interactors
MINTⁱ	Q15583
STRINGⁱ	9606.ENSP00000327959

PTM databases

iPTMnetⁱ	Q15583
PhosphoSitePlusⁱ	Q15583

Polymorphism and mutation databases

BioMutaⁱ	TGIF1
DMDMⁱ	215274200

Proteomic databases

EPDⁱ	Q15583
MaxQBⁱ	Q15583
PaxDbⁱ	Q15583
PeptideAtlasⁱ	Q15583
PRIDEⁱ	Q15583
ProteomicsDBⁱ	60646 60647 [Q15583-2] 60648 [Q15583-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Organism-specific databases

CTDⁱ	7050
DisGeNETⁱ	7050
EuPathDBⁱ	HostDB:ENSG00000177426.20
GeneCardsⁱ	TGIF1
GeneReviewsⁱ	TGIF1
H-InvDBⁱ	HIX0174209
HGNCⁱ	HGNC:11776 TGIF1
HPAⁱ	HPA062160
MalaCardsⁱ	TGIF1
MIMⁱ	142946 phenotype 602630 gene
neXtProtⁱ	NX_Q15583
OpenTargetsⁱ	ENSG00000177426
Orphanetⁱ	93925 Alobar holoprosencephaly 93924 Lobar holoprosencephaly 280200 Microform holoprosencephaly 93926 Midline interhemispheric variant of holoprosencephaly 220386 Semilobar holoprosencephaly 280195 Septopreoptic holoprosencephaly
PharmGKBⁱ	PA36489
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0773 Eukaryota ENOG410XPMQ LUCA
GeneTreeⁱ	ENSGT00550000074260
HOGENOMⁱ	HOG000232039
HOVERGENⁱ	HBG001143
InParanoidⁱ	Q15583
KOⁱ	K19383
OMAⁱ	APFHFCQ
OrthoDBⁱ	EOG091G0GOO
PhylomeDBⁱ	Q15583
TreeFamⁱ	TF318093

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SignaLinkⁱ	Q15583
SIGNORⁱ	Q15583

Miscellaneous databases

EvolutionaryTraceⁱ	Q15583
GeneWikiⁱ	Homeobox_protein_TGIF1
GenomeRNAiⁱ	7050
Protein Ontology More...PROⁱ	PR:Q15583
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177426 Expressed in 208 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_TGIF1
ExpressionAtlasⁱ	Q15583 baseline and differential
Genevisibleⁱ	Q15583 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR008422 Homeobox_KN_domain
Pfamⁱ	View protein in Pfam PF05920 Homeobox_KN, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TGIF1_HUMAN
Accessionⁱ	Q15583Primary (citable) accession number: Q15583 Secondary accession number(s): A6NE42 , A6NLU7, F8VZB6, Q6ICR0, Q8N5X9, Q9NRS0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 196 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q15583 (TGIF1_HUMAN)

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Homeobox protein TGIF1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

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GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ