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Protein

Homeobox protein TGIF1

Gene

TGIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi164 – 226Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q15583

SIGNOR Signaling Network Open Resource

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SIGNORi
Q15583

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein TGIF1
Alternative name(s):
5'-TG-3'-interacting factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TGIF1
Synonyms:TGIF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000177426.20

Human Gene Nomenclature Database

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HGNCi
HGNC:11776 TGIF1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602630 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15583

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Holoprosencephaly 4 (HPE4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
See also OMIM:142946
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_009961157S → C in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909066EnsemblClinVar.1
Natural variantiVAR_009962192P → R in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909067EnsemblClinVar.1
Natural variantiVAR_023803236Q → L in HPE4. 1 PublicationCorresponds to variant dbSNP:rs28939693Ensembl.1
Natural variantiVAR_009963280T → A in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909068EnsemblClinVar.1
Natural variantiVAR_009964291S → F in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909069EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Holoprosencephaly

Organism-specific databases

DisGeNET

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DisGeNETi
7050

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
TGIF1

MalaCards human disease database

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MalaCardsi
TGIF1
MIMi142946 phenotype

Open Targets

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OpenTargetsi
ENSG00000177426

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
93925 Alobar holoprosencephaly
93924 Lobar holoprosencephaly
280200 Microform holoprosencephaly
93926 Midline interhemispheric variant of holoprosencephaly
220386 Semilobar holoprosencephaly
280195 Septopreoptic holoprosencephaly

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36489

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TGIF1

Domain mapping of disease mutations (DMDM)

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DMDMi
215274200

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000493181 – 401Homeobox protein TGIF1Add BLAST401

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15583

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15583

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15583

PeptideAtlas

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PeptideAtlasi
Q15583

PRoteomics IDEntifications database

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PRIDEi
Q15583

ProteomicsDB human proteome resource

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ProteomicsDBi
60646
60647 [Q15583-2]
60648 [Q15583-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15583

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15583

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177426 Expressed in 208 organ(s), highest expression level in left coronary artery

CleanEx database of gene expression profiles

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CleanExi
HS_TGIF1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15583 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15583 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA062160

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTBP, SMAD2, SMAD3 and HDAC1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112908, 22 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q15583

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q15583

Protein interaction database and analysis system

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IntActi
Q15583, 14 interactors

Molecular INTeraction database

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MINTi
Q15583

STRING: functional protein association networks

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STRINGi
9606.ENSP00000327959

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1401
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q15583

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15583

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q15583

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi153 – 157CTBP-binding motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi165 – 168Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0773 Eukaryota
ENOG410XPMQ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155230

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000232039

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001143

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15583

KEGG Orthology (KO)

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KOi
K19383

Identification of Orthologs from Complete Genome Data

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OMAi
APFHFCQ

Database of Orthologous Groups

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OrthoDBi
EOG091G0GOO

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15583

TreeFam database of animal gene trees

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TreeFami
TF318093

Family and domain databases

Conserved Domains Database

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CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain

Pfam protein domain database

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Pfami
View protein in Pfam
PF05920 Homeobox_KN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15583-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLAQSRVSA GVGSPHCSGS GGGGSDSFPW PASHPGNPQC SFSTAFLASP
60 70 80 90 100
RLSRGTLAYL PPAPWSSLAT PSALLGSSCA PPPPPARCPQ PRALSPELGT
110 120 130 140 150
KAGPRRPHRW ELPRSPSQGA QGPAPRRRLL ETMKGIVAAS GSETEDEDSM
160 170 180 190 200
DIPLDLSSSA GSGKRRRRGN LPKESVQILR DWLYEHRYNA YPSEQEKALL
210 220 230 240 250
SQQTHLSTLQ VCNWFINARR RLLPDMLRKD GKDPNQFTIS RRGAKISETS
260 270 280 290 300
SVESVMGIKN FMPALEETPF HSCTAGPNPT LGRPLSPKPS SPGSVLARPS
310 320 330 340 350
VICHTTVTAL KDVPFSLCQS VGVGQNTDIQ QIAAKNFTDT SLMYPEDTCK
360 370 380 390 400
SGPSTNTQSG LFNTPPPTPP DLNQDFSGFQ LLVDVALKRA AEMELQAKLT

A
Length:401
Mass (Da):43,013
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D9C76AFB37A29F0
GO
Isoform 2 (identifier: Q15583-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.
     130-133: LETM → MKGK

Show »
Length:272
Mass (Da):29,737
Checksum:i948D1F689996E84E
GO
Isoform 3 (identifier: Q15583-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     116-134: PSQGAQGPAPRRRLLETMK → MTCSGKSCALARSSLTSSQ

Show »
Length:286
Mass (Da):31,064
Checksum:i39EA173EECBFD391
GO
Isoform 4 (identifier: Q15583-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-149: Missing.

Note: No experimental confirmation available.
Show »
Length:252
Mass (Da):27,715
Checksum:iA3426BEBB9753C87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VUY0F8VUY0_HUMAN
Homeobox protein TGIF1
TGIF1
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVS9F8VVS9_HUMAN
Homeobox protein TGIF1
TGIF1
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXG3F8VXG3_HUMAN
Homeobox protein TGIF1
TGIF1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VW34F8VW34_HUMAN
Homeobox protein TGIF1
TGIF1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYL4F8VYL4_HUMAN
Homeobox protein TGIF1
TGIF1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VX54F8VX54_HUMAN
Homeobox protein TGIF1
TGIF1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZH2F8VZH2_HUMAN
Homeobox protein TGIF1
TGIF1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWK5F8VWK5_HUMAN
Homeobox protein TGIF1
TGIF1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1J9F8W1J9_HUMAN
Homeobox protein TGIF1
TGIF1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS32J3KS32_HUMAN
Homeobox protein TGIF1
TGIF1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96P → Q in AAH31268 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009961157S → C in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909066EnsemblClinVar.1
Natural variantiVAR_009962192P → R in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909067EnsemblClinVar.1
Natural variantiVAR_023803236Q → L in HPE4. 1 PublicationCorresponds to variant dbSNP:rs28939693Ensembl.1
Natural variantiVAR_009963280T → A in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909068EnsemblClinVar.1
Natural variantiVAR_047363289P → S. Corresponds to variant dbSNP:rs11571512Ensembl.1
Natural variantiVAR_009964291S → F in HPE4. 1 PublicationCorresponds to variant dbSNP:rs121909069EnsemblClinVar.1
Natural variantiVAR_020151292P → L. Corresponds to variant dbSNP:rs2229333Ensembl.1
Natural variantiVAR_061268292P → S2 PublicationsCorresponds to variant dbSNP:rs4468717Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468481 – 149Missing in isoform 4. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_0130201 – 129Missing in isoform 2. 4 PublicationsAdd BLAST129
Alternative sequenceiVSP_0431081 – 115Missing in isoform 3. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_043109116 – 134PSQGA…LETMK → MTCSGKSCALARSSLTSSQ in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_013021130 – 133LETM → MKGK in isoform 2. 4 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X89750 mRNA Translation: CAA61897.1
AF179900 mRNA Translation: AAF81643.1
CR450333 mRNA Translation: CAG29329.1
AK291112 mRNA Translation: BAF83801.1
AP001025 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01672.1
BC000814 mRNA Translation: AAH00814.1
BC031268 mRNA Translation: AAH31268.1
BE296707 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11832.1 [Q15583-3]
CCDS11833.1 [Q15583-2]
CCDS11834.1 [Q15583-1]
CCDS11835.1 [Q15583-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001265611.1, NM_001278682.1
NP_001265613.1, NM_001278684.1 [Q15583-2]
NP_001265615.1, NM_001278686.1 [Q15583-4]
NP_003235.1, NM_003244.3 [Q15583-2]
NP_733796.2, NM_170695.3 [Q15583-1]
NP_775299.1, NM_173207.2 [Q15583-3]
NP_775300.1, NM_173208.2 [Q15583-2]
NP_775301.1, NM_173209.2 [Q15583-4]
NP_775302.1, NM_173210.2 [Q15583-4]
NP_775303.1, NM_173211.1 [Q15583-4]
NP_777480.1, NM_174886.2 [Q15583-4]
XP_011524037.1, XM_011525735.2 [Q15583-4]
XP_016881447.1, XM_017025958.1 [Q15583-2]
XP_016881448.1, XM_017025959.1 [Q15583-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.373550

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330513; ENSP00000327959; ENSG00000177426 [Q15583-1]
ENST00000343820; ENSP00000339631; ENSG00000177426 [Q15583-2]
ENST00000345133; ENSP00000343969; ENSG00000177426 [Q15583-4]
ENST00000400167; ENSP00000383031; ENSG00000177426 [Q15583-4]
ENST00000401449; ENSP00000385206; ENSG00000177426 [Q15583-4]
ENST00000405385; ENSP00000384970; ENSG00000177426 [Q15583-4]
ENST00000407501; ENSP00000384133; ENSG00000177426 [Q15583-2]
ENST00000472042; ENSP00000449501; ENSG00000177426 [Q15583-4]
ENST00000548489; ENSP00000447747; ENSG00000177426 [Q15583-4]
ENST00000551541; ENSP00000450025; ENSG00000177426 [Q15583-4]
ENST00000618001; ENSP00000483499; ENSG00000177426 [Q15583-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7050

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7050

UCSC genome browser

More...
UCSCi
uc002klu.5 human [Q15583-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89750 mRNA Translation: CAA61897.1
AF179900 mRNA Translation: AAF81643.1
CR450333 mRNA Translation: CAG29329.1
AK291112 mRNA Translation: BAF83801.1
AP001025 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01672.1
BC000814 mRNA Translation: AAH00814.1
BC031268 mRNA Translation: AAH31268.1
BE296707 mRNA No translation available.
CCDSiCCDS11832.1 [Q15583-3]
CCDS11833.1 [Q15583-2]
CCDS11834.1 [Q15583-1]
CCDS11835.1 [Q15583-4]
RefSeqiNP_001265611.1, NM_001278682.1
NP_001265613.1, NM_001278684.1 [Q15583-2]
NP_001265615.1, NM_001278686.1 [Q15583-4]
NP_003235.1, NM_003244.3 [Q15583-2]
NP_733796.2, NM_170695.3 [Q15583-1]
NP_775299.1, NM_173207.2 [Q15583-3]
NP_775300.1, NM_173208.2 [Q15583-2]
NP_775301.1, NM_173209.2 [Q15583-4]
NP_775302.1, NM_173210.2 [Q15583-4]
NP_775303.1, NM_173211.1 [Q15583-4]
NP_777480.1, NM_174886.2 [Q15583-4]
XP_011524037.1, XM_011525735.2 [Q15583-4]
XP_016881447.1, XM_017025958.1 [Q15583-2]
XP_016881448.1, XM_017025959.1 [Q15583-4]
UniGeneiHs.373550

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LK2NMR-A171-248[»]
6FQPX-ray2.42A/B150-248[»]
6FQQX-ray3.25A/B/D/E161-229[»]
ProteinModelPortaliQ15583
SMRiQ15583
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112908, 22 interactors
CORUMiQ15583
ELMiQ15583
IntActiQ15583, 14 interactors
MINTiQ15583
STRINGi9606.ENSP00000327959

PTM databases

iPTMnetiQ15583
PhosphoSitePlusiQ15583

Polymorphism and mutation databases

BioMutaiTGIF1
DMDMi215274200

Proteomic databases

EPDiQ15583
MaxQBiQ15583
PaxDbiQ15583
PeptideAtlasiQ15583
PRIDEiQ15583
ProteomicsDBi60646
60647 [Q15583-2]
60648 [Q15583-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330513; ENSP00000327959; ENSG00000177426 [Q15583-1]
ENST00000343820; ENSP00000339631; ENSG00000177426 [Q15583-2]
ENST00000345133; ENSP00000343969; ENSG00000177426 [Q15583-4]
ENST00000400167; ENSP00000383031; ENSG00000177426 [Q15583-4]
ENST00000401449; ENSP00000385206; ENSG00000177426 [Q15583-4]
ENST00000405385; ENSP00000384970; ENSG00000177426 [Q15583-4]
ENST00000407501; ENSP00000384133; ENSG00000177426 [Q15583-2]
ENST00000472042; ENSP00000449501; ENSG00000177426 [Q15583-4]
ENST00000548489; ENSP00000447747; ENSG00000177426 [Q15583-4]
ENST00000551541; ENSP00000450025; ENSG00000177426 [Q15583-4]
ENST00000618001; ENSP00000483499; ENSG00000177426 [Q15583-3]
GeneIDi7050
KEGGihsa:7050
UCSCiuc002klu.5 human [Q15583-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7050
DisGeNETi7050
EuPathDBiHostDB:ENSG00000177426.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TGIF1
GeneReviewsiTGIF1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0174209
HGNCiHGNC:11776 TGIF1
HPAiHPA062160
MalaCardsiTGIF1
MIMi142946 phenotype
602630 gene
neXtProtiNX_Q15583
OpenTargetsiENSG00000177426
Orphaneti93925 Alobar holoprosencephaly
93924 Lobar holoprosencephaly
280200 Microform holoprosencephaly
93926 Midline interhemispheric variant of holoprosencephaly
220386 Semilobar holoprosencephaly
280195 Septopreoptic holoprosencephaly
PharmGKBiPA36489

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00940000155230
HOGENOMiHOG000232039
HOVERGENiHBG001143
InParanoidiQ15583
KOiK19383
OMAiAPFHFCQ
OrthoDBiEOG091G0GOO
PhylomeDBiQ15583
TreeFamiTF318093

Enzyme and pathway databases

ReactomeiR-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SignaLinkiQ15583
SIGNORiQ15583

Miscellaneous databases

EvolutionaryTraceiQ15583

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Homeobox_protein_TGIF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7050

Protein Ontology

More...
PROi
PR:Q15583

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177426 Expressed in 208 organ(s), highest expression level in left coronary artery
CleanExiHS_TGIF1
ExpressionAtlasiQ15583 baseline and differential
GenevisibleiQ15583 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGIF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15583
Secondary accession number(s): A6NE42
, A6NLU7, F8VZB6, Q6ICR0, Q8N5X9, Q9NRS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: December 5, 2018
This is version 197 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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