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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit C

Gene

TAF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.2 Publications

GO - Molecular functioni

  • RNA polymerase I CORE element sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit C
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 110 kDa
Short name:
TAFI110
TATA box-binding protein-associated factor 1C
Short name:
TBP-associated factor 1C
Transcription initiation factor SL1/TIF-IB subunit C
Gene namesi
Name:TAF1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103168.16
HGNCiHGNC:11534 TAF1C
MIMi604905 gene
neXtProtiNX_Q15572

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9013
OpenTargetsiENSG00000103168
PharmGKBiPA36309

Polymorphism and mutation databases

BioMutaiTAF1C
DMDMi313104019

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188631 – 869TATA box-binding protein-associated factor RNA polymerase I subunit CAdd BLAST869

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei834PhosphothreonineCombined sources1
Modified residuei848PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15572
MaxQBiQ15572
PaxDbiQ15572
PeptideAtlasiQ15572
PRIDEiQ15572
ProteomicsDBi60638
60639 [Q15572-2]
60640 [Q15572-4]
60641 [Q15572-5]
60642 [Q15572-6]

PTM databases

iPTMnetiQ15572
PhosphoSitePlusiQ15572

Expressioni

Gene expression databases

BgeeiENSG00000103168 Expressed in 196 organ(s), highest expression level in myometrium
CleanExiHS_TAF1C
ExpressionAtlasiQ15572 baseline and differential
GenevisibleiQ15572 HS

Organism-specific databases

HPAiHPA072229

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114482, 43 interactors
CORUMiQ15572
DIPiDIP-269N
IntActiQ15572, 13 interactors
MINTiQ15572
STRINGi9606.ENSP00000367802

Structurei

3D structure databases

ProteinModelPortaliQ15572
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IH3X Eukaryota
ENOG41101B7 LUCA
GeneTreeiENSGT00390000010767
HOVERGENiHBG079499
InParanoidiQ15572
KOiK15214
OMAiLKWNHGL
OrthoDBiEOG091G09D1
PhylomeDBiQ15572
TreeFamiTF351959

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR038801 TAF1C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR15319 PTHR15319, 2 hits
SUPFAMiSSF50978 SSF50978, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q15572-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL
60 70 80 90 100
HVTKDLLWEP ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV
110 120 130 140 150
LDVTEQISRF LLDHGDVAFA PLGKLMLENF KLEGAGSRTK KKTVVSVKKL
160 170 180 190 200
LQDLGGHQPW GCPWAYLSNR QRRFSILGGP ILGTSVASHL AELLHEELVL
210 220 230 240 250
RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL HFQEVVLTPG
260 270 280 290 300
DNPQFLGKPG RIQLQGPVRQ VVTCTVQGES KALIYTFLPH WLTCYLTPGP
310 320 330 340 350
FHPSSALLAV RSDYHCAVWK FGKQWQPTLL QAMQVEKGAT GISLSPHLPG
360 370 380 390 400
ELAICSRSGA VCLWSPEDGL RQIYRDPETL VFRDSSSWRW ADFTAHPRVL
410 420 430 440 450
TVGDRTGVKM LDTQGPPGCG LLLFRLGAEA SCQKGERVLL TQYLGHSSPK
460 470 480 490 500
CLPPTLHLVC TQFSLYLVDE RLPLVPMLKW NHGLPSPLLL ARLLPPPRPS
510 520 530 540 550
CVQPLLLGGQ GGQLQLLHLA GEGASVPRLA GPPQSLPSRI DSLPAFPLLE
560 570 580 590 600
PKIQWRLQER LKAPTIGLAA VVPPLPSAPT PGLVLFQLSA AGDVFYQQLR
610 620 630 640 650
PQVDSSLRRD AGPPGDTQPD CHAPTASWTS QDTAGCSQWL KALLKVPLAP
660 670 680 690 700
PVWTAPTFTH RQMLGSTELR REEEEGQRLG VLRKAMARGQ LLLQRDLGSL
710 720 730 740 750
PAAEPPPAPE SGLEDKLSER LGEAWAGRGA AWWERQQGRT SEPGRQTRRP
760 770 780 790 800
KRRTQLSSSF SLSGHVDPSE DTSSPHSPEW PPADALPLPP TTPPSQELTP
810 820 830 840 850
DACAQGVPSE QRQMLRDYMA KLPPQRDTPG CATTPPHSQA SSVRATRSQQ
860
HTPVLSSSQP LRKKPRMGF
Length:869
Mass (Da):95,213
Last modified:November 30, 2010 - v2
Checksum:i6AAFAF296D98A5DB
GO
Isoform 2 (identifier: Q15572-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T
     521-521: Missing.

Note: No experimental confirmation available.
Show »
Length:775
Mass (Da):84,985
Checksum:i29B8C09D7F9228EF
GO
Isoform 4 (identifier: Q15572-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.

Note: No experimental confirmation available.
Show »
Length:537
Mass (Da):58,441
Checksum:i6C36809B5E6D2203
GO
Isoform 5 (identifier: Q15572-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):49,946
Checksum:iDBE3CAD1F8541D45
GO
Isoform 6 (identifier: Q15572-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T

Note: No experimental confirmation available.
Show »
Length:843
Mass (Da):92,284
Checksum:i75D245B40F7E9948
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR71H3BR71_HUMAN
TATA box-binding protein-associated...
TAF1C
380Annotation score:
H3BNH3H3BNH3_HUMAN
TATA box-binding protein-associated...
TAF1C
146Annotation score:
H3BR91H3BR91_HUMAN
TATA box-binding protein-associated...
TAF1C
209Annotation score:
H3BUZ7H3BUZ7_HUMAN
TATA box-binding protein-associated...
TAF1C
136Annotation score:
H3BQZ8H3BQZ8_HUMAN
TATA box-binding protein-associated...
TAF1C
93Annotation score:
H3BTQ6H3BTQ6_HUMAN
TATA box-binding protein-associated...
TAF1C
70Annotation score:
H3BMQ4H3BMQ4_HUMAN
TATA box-binding protein-associated...
TAF1C
52Annotation score:
H3BQH8H3BQH8_HUMAN
TATA box-binding protein-associated...
TAF1C
58Annotation score:

Sequence cautioni

The sequence BAD92831 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244E → K in BAH13010 (PubMed:14702039).Curated1
Sequence conflicti481N → S in BAH14353 (PubMed:14702039).Curated1
Sequence conflicti777S → G in BAH14144 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05896691C → Y4 PublicationsCorresponds to variant dbSNP:rs4782591Ensembl.1
Natural variantiVAR_023245304S → F1 PublicationCorresponds to variant dbSNP:rs4150145Ensembl.1
Natural variantiVAR_023246357R → H1 PublicationCorresponds to variant dbSNP:rs4150147Ensembl.1
Natural variantiVAR_023247387S → L1 PublicationCorresponds to variant dbSNP:rs4150151Ensembl.1
Natural variantiVAR_023248518H → Y1 PublicationCorresponds to variant dbSNP:rs4150165Ensembl.1
Natural variantiVAR_057261523G → R. Corresponds to variant dbSNP:rs4150167Ensembl.1
Natural variantiVAR_023249573P → L1 PublicationCorresponds to variant dbSNP:rs4150170Ensembl.1
Natural variantiVAR_023250575L → M3 PublicationsCorresponds to variant dbSNP:rs2230129Ensembl.1
Natural variantiVAR_023251591A → G1 PublicationCorresponds to variant dbSNP:rs4150172Ensembl.1
Natural variantiVAR_023252635G → S1 PublicationCorresponds to variant dbSNP:rs4150173Ensembl.1
Natural variantiVAR_023253791T → M1 PublicationCorresponds to variant dbSNP:rs4150175Ensembl.1
Natural variantiVAR_023254793P → L2 PublicationsCorresponds to variant dbSNP:rs2230131Ensembl.1
Natural variantiVAR_057262808P → S. Corresponds to variant dbSNP:rs3743640Ensembl.1
Natural variantiVAR_023255816R → H1 PublicationCorresponds to variant dbSNP:rs4150176Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0380861 – 409Missing in isoform 5. 1 PublicationAdd BLAST409
Alternative sequenceiVSP_0380871 – 332Missing in isoform 4. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_0151531 – 67Missing in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_015154280 – 306SKALI…HPSSA → T in isoform 2 and isoform 6. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_015156521Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39059 mRNA Translation: AAA62861.1
AK299060 mRNA Translation: BAH12941.1
AK299347 mRNA Translation: BAH13010.1
AK304261 mRNA Translation: BAH14144.1
AK315982 mRNA Translation: BAH14353.1
AB209594 mRNA Translation: BAD92831.1 Sequence problems.
AY158985 Genomic DNA Translation: AAN38818.1
AC009123 Genomic DNA No translation available.
BC028131 mRNA Translation: AAH28131.1
CCDSiCCDS32496.1 [Q15572-1]
CCDS45535.1 [Q15572-2]
CCDS58488.1 [Q15572-4]
CCDS58489.1 [Q15572-6]
PIRiA55384
RefSeqiNP_001230085.1, NM_001243156.1
NP_001230086.1, NM_001243157.1 [Q15572-4]
NP_001230087.1, NM_001243158.1 [Q15572-4]
NP_001230088.1, NM_001243159.1 [Q15572-5]
NP_005670.3, NM_005679.3
NP_647610.2, NM_139353.2
XP_005256283.1, XM_005256226.3 [Q15572-1]
XP_016879334.1, XM_017023845.1 [Q15572-6]
XP_016879337.1, XM_017023848.1 [Q15572-4]
UniGeneiHs.153022

Genome annotation databases

EnsembliENST00000341690; ENSP00000345305; ENSG00000103168 [Q15572-2]
ENST00000541676; ENSP00000437900; ENSG00000103168 [Q15572-4]
ENST00000566732; ENSP00000455933; ENSG00000103168 [Q15572-6]
ENST00000567759; ENSP00000455265; ENSG00000103168 [Q15572-1]
ENST00000570117; ENSP00000455247; ENSG00000103168 [Q15572-4]
GeneIDi9013
KEGGihsa:9013
UCSCiuc002fhm.4 human [Q15572-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39059 mRNA Translation: AAA62861.1
AK299060 mRNA Translation: BAH12941.1
AK299347 mRNA Translation: BAH13010.1
AK304261 mRNA Translation: BAH14144.1
AK315982 mRNA Translation: BAH14353.1
AB209594 mRNA Translation: BAD92831.1 Sequence problems.
AY158985 Genomic DNA Translation: AAN38818.1
AC009123 Genomic DNA No translation available.
BC028131 mRNA Translation: AAH28131.1
CCDSiCCDS32496.1 [Q15572-1]
CCDS45535.1 [Q15572-2]
CCDS58488.1 [Q15572-4]
CCDS58489.1 [Q15572-6]
PIRiA55384
RefSeqiNP_001230085.1, NM_001243156.1
NP_001230086.1, NM_001243157.1 [Q15572-4]
NP_001230087.1, NM_001243158.1 [Q15572-4]
NP_001230088.1, NM_001243159.1 [Q15572-5]
NP_005670.3, NM_005679.3
NP_647610.2, NM_139353.2
XP_005256283.1, XM_005256226.3 [Q15572-1]
XP_016879334.1, XM_017023845.1 [Q15572-6]
XP_016879337.1, XM_017023848.1 [Q15572-4]
UniGeneiHs.153022

3D structure databases

ProteinModelPortaliQ15572
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114482, 43 interactors
CORUMiQ15572
DIPiDIP-269N
IntActiQ15572, 13 interactors
MINTiQ15572
STRINGi9606.ENSP00000367802

PTM databases

iPTMnetiQ15572
PhosphoSitePlusiQ15572

Polymorphism and mutation databases

BioMutaiTAF1C
DMDMi313104019

Proteomic databases

EPDiQ15572
MaxQBiQ15572
PaxDbiQ15572
PeptideAtlasiQ15572
PRIDEiQ15572
ProteomicsDBi60638
60639 [Q15572-2]
60640 [Q15572-4]
60641 [Q15572-5]
60642 [Q15572-6]

Protocols and materials databases

DNASUi9013
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341690; ENSP00000345305; ENSG00000103168 [Q15572-2]
ENST00000541676; ENSP00000437900; ENSG00000103168 [Q15572-4]
ENST00000566732; ENSP00000455933; ENSG00000103168 [Q15572-6]
ENST00000567759; ENSP00000455265; ENSG00000103168 [Q15572-1]
ENST00000570117; ENSP00000455247; ENSG00000103168 [Q15572-4]
GeneIDi9013
KEGGihsa:9013
UCSCiuc002fhm.4 human [Q15572-1]

Organism-specific databases

CTDi9013
DisGeNETi9013
EuPathDBiHostDB:ENSG00000103168.16
GeneCardsiTAF1C
H-InvDBiHIX0013290
HGNCiHGNC:11534 TAF1C
HPAiHPA072229
MIMi604905 gene
neXtProtiNX_Q15572
OpenTargetsiENSG00000103168
PharmGKBiPA36309
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH3X Eukaryota
ENOG41101B7 LUCA
GeneTreeiENSGT00390000010767
HOVERGENiHBG079499
InParanoidiQ15572
KOiK15214
OMAiLKWNHGL
OrthoDBiEOG091G09D1
PhylomeDBiQ15572
TreeFamiTF351959

Enzyme and pathway databases

ReactomeiR-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination

Miscellaneous databases

GeneWikiiTAF1C
GenomeRNAii9013
PROiPR:Q15572
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103168 Expressed in 196 organ(s), highest expression level in myometrium
CleanExiHS_TAF1C
ExpressionAtlasiQ15572 baseline and differential
GenevisibleiQ15572 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR038801 TAF1C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR15319 PTHR15319, 2 hits
SUPFAMiSSF50978 SSF50978, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAF1C_HUMAN
AccessioniPrimary (citable) accession number: Q15572
Secondary accession number(s): B7Z5K5
, B7Z5S4, B7Z908, B7Z9L7, Q59F67, Q8N6V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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