TAF1C

Functionⁱ

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.2 Publications

GO - Molecular functionⁱ

RNA polymerase I CORE element sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22368283

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of gene expression, epigenetic Source: Reactome
regulation of transcription by RNA polymerase I
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 12498690
termination of RNA polymerase I transcription Source: Reactome
transcription by RNA polymerase I
Source: ProtInc
Traceable author statementⁱ
- 7801123
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 7801123
transcription initiation from RNA polymerase I promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-427359 SIRT1 negatively regulates rRNA expression R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-73772 RNA Polymerase I Promoter Escape R-HSA-73777 RNA Polymerase I Chain Elongation R-HSA-73863 RNA Polymerase I Transcription Termination

Reactomeⁱ

R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TATA box-binding protein-associated factor RNA polymerase I subunit C Alternative name(s): RNA polymerase I-specific TBP-associated factor 110 kDa Short name: TAFI110 TATA box-binding protein-associated factor 1C Short name: TBP-associated factor 1C Transcription initiation factor SL1/TIF-IB subunit C
Gene namesⁱ	Name:TAF1C
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103168.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11534 TAF1C
MIMⁱ	604905 gene
neXtProtⁱ	NX_Q15572

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9013
Open Targets More...OpenTargetsⁱ	ENSG00000103168
PharmGKBⁱ	PA36309

Polymorphism and mutation databases

BioMutaⁱ	TAF1C
DMDMⁱ	313104019

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000118863	1 – 869	TATA box-binding protein-associated factor RNA polymerase I subunit CAdd BLAST		869

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	834	PhosphothreonineCombined sources		1
Modified residueⁱ	848	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q15572
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15572
PaxDbⁱ	Q15572
PeptideAtlas More...PeptideAtlasⁱ	Q15572
PRIDEⁱ	Q15572
ProteomicsDBⁱ	60638 60639 [Q15572-2] 60640 [Q15572-4] 60641 [Q15572-5] 60642 [Q15572-6]

PTM databases

iPTMnetⁱ	Q15572
PhosphoSitePlusⁱ	Q15572

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000103168 Expressed in 196 organ(s), highest expression level in myometrium
CleanExⁱ	HS_TAF1C
ExpressionAtlasⁱ	Q15572 baseline and differential
Genevisibleⁱ	Q15572 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA072229

HPAⁱ

HPA072229

Interactionⁱ

Subunit structureⁱ

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
SET	Q01105	4	EBI-2510659,EBI-1053182
TAF12	Q16514	2	EBI-2510659,EBI-1034238
TBP	P20226	3	EBI-2510659,EBI-355371

Protein-protein interaction databases

BioGridⁱ	114482, 43 interactors
CORUMⁱ	Q15572
Database of interacting proteins More...DIPⁱ	DIP-269N
IntActⁱ	Q15572, 13 interactors
Molecular INTeraction database More...MINTⁱ	Q15572
STRINGⁱ	9606.ENSP00000367802

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15572
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IH3X Eukaryota ENOG41101B7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010767
HOVERGENⁱ	HBG079499
InParanoidⁱ	Q15572
KEGG Orthology (KO) More...KOⁱ	K15214
OMAⁱ	LKWNHGL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09D1
PhylomeDBⁱ	Q15572
TreeFamⁱ	TF351959

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR038801 TAF1C IPR015943 WD40/YVTN_repeat-like_dom_sf IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR15319 PTHR15319, 2 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q15572-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL 
        60         70         80         90        100
HVTKDLLWEP ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV 
       110        120        130        140        150
LDVTEQISRF LLDHGDVAFA PLGKLMLENF KLEGAGSRTK KKTVVSVKKL 
       160        170        180        190        200
LQDLGGHQPW GCPWAYLSNR QRRFSILGGP ILGTSVASHL AELLHEELVL 
       210        220        230        240        250
RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL HFQEVVLTPG 
       260        270        280        290        300
DNPQFLGKPG RIQLQGPVRQ VVTCTVQGES KALIYTFLPH WLTCYLTPGP 
       310        320        330        340        350
FHPSSALLAV RSDYHCAVWK FGKQWQPTLL QAMQVEKGAT GISLSPHLPG 
       360        370        380        390        400
ELAICSRSGA VCLWSPEDGL RQIYRDPETL VFRDSSSWRW ADFTAHPRVL 
       410        420        430        440        450
TVGDRTGVKM LDTQGPPGCG LLLFRLGAEA SCQKGERVLL TQYLGHSSPK 
       460        470        480        490        500
CLPPTLHLVC TQFSLYLVDE RLPLVPMLKW NHGLPSPLLL ARLLPPPRPS 
       510        520        530        540        550
CVQPLLLGGQ GGQLQLLHLA GEGASVPRLA GPPQSLPSRI DSLPAFPLLE 
       560        570        580        590        600
PKIQWRLQER LKAPTIGLAA VVPPLPSAPT PGLVLFQLSA AGDVFYQQLR 
       610        620        630        640        650
PQVDSSLRRD AGPPGDTQPD CHAPTASWTS QDTAGCSQWL KALLKVPLAP 
       660        670        680        690        700
PVWTAPTFTH RQMLGSTELR REEEEGQRLG VLRKAMARGQ LLLQRDLGSL 
       710        720        730        740        750
PAAEPPPAPE SGLEDKLSER LGEAWAGRGA AWWERQQGRT SEPGRQTRRP 
       760        770        780        790        800
KRRTQLSSSF SLSGHVDPSE DTSSPHSPEW PPADALPLPP TTPPSQELTP 
       810        820        830        840        850
DACAQGVPSE QRQMLRDYMA KLPPQRDTPG CATTPPHSQA SSVRATRSQQ 
       860 
HTPVLSSSQP LRKKPRMGF

Length:869

Mass (Da):95,213

Last modified:November 30, 2010 - v2

Checksum:ⁱ6AAFAF296D98A5DB

GO

Isoform 2 (identifier: Q15572-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T
     521-521: Missing.

« Hide

        10         20         30         40         50
MLPPLIDPWD PGLTARDLLF RGGCRYRKRP RVVLDVTEQI SRFLLDHGDV 
        60         70         80         90        100
AFAPLGKLML ENFKLEGAGS RTKKKTVVSV KKLLQDLGGH QPWGCPWAYL 
       110        120        130        140        150
SNRQRRFSIL GGPILGTSVA SHLAELLHEE LVLRWEQLLL DEACTGGALA 
       160        170        180        190        200
WVPGRTPQFG QLVYPAGGAQ DRLHFQEVVL TPGDNPQFLG KPGRIQLQGP 
       210        220        230        240        250
VRQVVTCTVQ GETLLAVRSD YHCAVWKFGK QWQPTLLQAM QVEKGATGIS 
       260        270        280        290        300
LSPHLPGELA ICSRSGAVCL WSPEDGLRQI YRDPETLVFR DSSSWRWADF 
       310        320        330        340        350
TAHPRVLTVG DRTGVKMLDT QGPPGCGLLL FRLGAEASCQ KGERVLLTQY 
       360        370        380        390        400
LGHSSPKCLP PTLHLVCTQF SLYLVDERLP LVPMLKWNHG LPSPLLLARL 
       410        420        430        440        450
LPPPRPSCVQ PLLLGGQGGQ LQLLHLAEGA SVPRLAGPPQ SLPSRIDSLP 
       460        470        480        490        500
AFPLLEPKIQ WRLQERLKAP TIGLAAVVPP LPSAPTPGLV LFQLSAAGDV 
       510        520        530        540        550
FYQQLRPQVD SSLRRDAGPP GDTQPDCHAP TASWTSQDTA GCSQWLKALL 
       560        570        580        590        600
KVPLAPPVWT APTFTHRQML GSTELRREEE EGQRLGVLRK AMARGQLLLQ 
       610        620        630        640        650
RDLGSLPAAE PPPAPESGLE DKLSERLGEA WAGRGAAWWE RQQGRTSEPG 
       660        670        680        690        700
RQTRRPKRRT QLSSSFSLSG HVDPSEDTSS PHSPEWPPAD ALPLPPTTPP 
       710        720        730        740        750
SQELTPDACA QGVPSEQRQM LRDYMAKLPP QRDTPGCATT PPHSQASSVR 
       760        770 
ATRSQQHTPV LSSSQPLRKK PRMGF

Note: No experimental confirmation available.

Show »

Length:775

Mass (Da):84,985

Checksum:ⁱ29B8C09D7F9228EF

GO

Isoform 4 (identifier: Q15572-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-332: Missing.

« Hide

        10         20         30         40         50
MQVEKGATGI SLSPHLPGEL AICSRSGAVC LWSPEDGLRQ IYRDPETLVF 
        60         70         80         90        100
RDSSSWRWAD FTAHPRVLTV GDRTGVKMLD TQGPPGCGLL LFRLGAEASC 
       110        120        130        140        150
QKGERVLLTQ YLGHSSPKCL PPTLHLVCTQ FSLYLVDERL PLVPMLKWNH 
       160        170        180        190        200
GLPSPLLLAR LLPPPRPSCV QPLLLGGQGG QLQLLHLAGE GASVPRLAGP 
       210        220        230        240        250
PQSLPSRIDS LPAFPLLEPK IQWRLQERLK APTIGLAAVV PPLPSAPTPG 
       260        270        280        290        300
LVLFQLSAAG DVFYQQLRPQ VDSSLRRDAG PPGDTQPDCH APTASWTSQD 
       310        320        330        340        350
TAGCSQWLKA LLKVPLAPPV WTAPTFTHRQ MLGSTELRRE EEEGQRLGVL 
       360        370        380        390        400
RKAMARGQLL LQRDLGSLPA AEPPPAPESG LEDKLSERLG EAWAGRGAAW 
       410        420        430        440        450
WERQQGRTSE PGRQTRRPKR RTQLSSSFSL SGHVDPSEDT SSPHSPEWPP 
       460        470        480        490        500
ADALPLPPTT PPSQELTPDA CAQGVPSEQR QMLRDYMAKL PPQRDTPGCA 
       510        520        530 
TTPPHSQASS VRATRSQQHT PVLSSSQPLR KKPRMGF

Note: No experimental confirmation available.

Show »

Length:537

Mass (Da):58,441

Checksum:ⁱ6C36809B5E6D2203

GO

Isoform 5 (identifier: Q15572-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-409: Missing.

« Hide

        10         20         30         40         50
MLDTQGPPGC GLLLFRLGAE ASCQKGERVL LTQYLGHSSP KCLPPTLHLV 
        60         70         80         90        100
CTQFSLYLVD ERLPLVPMLK WNHGLPSPLL LARLLPPPRP SCVQPLLLGG 
       110        120        130        140        150
QGGQLQLLHL AGEGASVPRL AGPPQSLPSR IDSLPAFPLL EPKIQWRLQE 
       160        170        180        190        200
RLKAPTIGLA AVVPPLPSAP TPGLVLFQLS AAGDVFYQQL RPQVDSSLRR 
       210        220        230        240        250
DAGPPGDTQP DCHAPTASWT SQDTAGCSQW LKALLKVPLA PPVWTAPTFT 
       260        270        280        290        300
HRQMLGSTEL RREEEEGQRL GVLRKAMARG QLLLQRDLGS LPAAEPPPAP 
       310        320        330        340        350
ESGLEDKLSE RLGEAWAGRG AAWWERQQGR TSEPGRQTRR PKRRTQLSSS 
       360        370        380        390        400
FSLSGHVDPS EDTSSPHSPE WPPADALPLP PTTPPSQELT PDACAQGVPS 
       410        420        430        440        450
EQRQMLRDYM AKLPPQRDTP GCATTPPHSQ ASSVRATRSQ QHTPVLSSSQ 
       460
PLRKKPRMGF

Note: No experimental confirmation available.

Show »

Length:460

Mass (Da):49,946

Checksum:ⁱDBE3CAD1F8541D45

GO

Isoform 6 (identifier: Q15572-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T

« Hide

        10         20         30         40         50
MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL 
        60         70         80         90        100
HVTKDLLWEP ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV 
       110        120        130        140        150
LDVTEQISRF LLDHGDVAFA PLGKLMLENF KLEGAGSRTK KKTVVSVKKL 
       160        170        180        190        200
LQDLGGHQPW GCPWAYLSNR QRRFSILGGP ILGTSVASHL AELLHEELVL 
       210        220        230        240        250
RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL HFQEVVLTPG 
       260        270        280        290        300
DNPQFLGKPG RIQLQGPVRQ VVTCTVQGET LLAVRSDYHC AVWKFGKQWQ 
       310        320        330        340        350
PTLLQAMQVE KGATGISLSP HLPGELAICS RSGAVCLWSP EDGLRQIYRD 
       360        370        380        390        400
PETLVFRDSS SWRWADFTAH PRVLTVGDRT GVKMLDTQGP PGCGLLLFRL 
       410        420        430        440        450
GAEASCQKGE RVLLTQYLGH SSPKCLPPTL HLVCTQFSLY LVDERLPLVP 
       460        470        480        490        500
MLKWNHGLPS PLLLARLLPP PRPSCVQPLL LGGQGGQLQL LHLAGEGASV 
       510        520        530        540        550
PRLAGPPQSL PSRIDSLPAF PLLEPKIQWR LQERLKAPTI GLAAVVPPLP 
       560        570        580        590        600
SAPTPGLVLF QLSAAGDVFY QQLRPQVDSS LRRDAGPPGD TQPDCHAPTA 
       610        620        630        640        650
SWTSQDTAGC SQWLKALLKV PLAPPVWTAP TFTHRQMLGS TELRREEEEG 
       660        670        680        690        700
QRLGVLRKAM ARGQLLLQRD LGSLPAAEPP PAPESGLEDK LSERLGEAWA 
       710        720        730        740        750
GRGAAWWERQ QGRTSEPGRQ TRRPKRRTQL SSSFSLSGHV DPSEDTSSPH 
       760        770        780        790        800
SPEWPPADAL PLPPTTPPSQ ELTPDACAQG VPSEQRQMLR DYMAKLPPQR 
       810        820        830        840 
DTPGCATTPP HSQASSVRAT RSQQHTPVLS SSQPLRKKPR MGF

Note: No experimental confirmation available.

Show »

Length:843

Mass (Da):92,284

Checksum:ⁱ75D245B40F7E9948

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
H3BR71	H3BR71_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit C	TAF1C	380	Annotation score:
H3BNH3	H3BNH3_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit C	TAF1C	146	Annotation score:
H3BR91	H3BR91_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit C	TAF1C	209	Annotation score:
H3BUZ7	H3BUZ7_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit C	TAF1C	136	Annotation score:
H3BQZ8	H3BQZ8_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit C	TAF1C	93	Annotation score:
H3BTQ6	H3BTQ6_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit C	TAF1C	70	Annotation score:
H3BMQ4	H3BMQ4_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit C	TAF1C	52	Annotation score:
H3BQH8	H3BQH8_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit C	TAF1C	58	Annotation score:

Sequence cautionⁱ

The sequence BAD92831 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	244	E → K in BAH13010 (PubMed:14702039).Curated	1
Sequence conflictⁱ	481	N → S in BAH14353 (PubMed:14702039).Curated	1
Sequence conflictⁱ	777	S → G in BAH14144 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_058966	91	C → Y4 PublicationsCorresponds to variant dbSNP:rs4782591Ensembl.	1
Natural variantⁱVAR_023245	304	S → F1 PublicationCorresponds to variant dbSNP:rs4150145Ensembl.	1
Natural variantⁱVAR_023246	357	R → H1 PublicationCorresponds to variant dbSNP:rs4150147Ensembl.	1
Natural variantⁱVAR_023247	387	S → L1 PublicationCorresponds to variant dbSNP:rs4150151Ensembl.	1
Natural variantⁱVAR_023248	518	H → Y1 PublicationCorresponds to variant dbSNP:rs4150165Ensembl.	1
Natural variantⁱVAR_057261	523	G → R. Corresponds to variant dbSNP:rs4150167Ensembl.	1
Natural variantⁱVAR_023249	573	P → L1 PublicationCorresponds to variant dbSNP:rs4150170Ensembl.	1
Natural variantⁱVAR_023250	575	L → M3 PublicationsCorresponds to variant dbSNP:rs2230129Ensembl.	1
Natural variantⁱVAR_023251	591	A → G1 PublicationCorresponds to variant dbSNP:rs4150172Ensembl.	1
Natural variantⁱVAR_023252	635	G → S1 PublicationCorresponds to variant dbSNP:rs4150173Ensembl.	1
Natural variantⁱVAR_023253	791	T → M1 PublicationCorresponds to variant dbSNP:rs4150175Ensembl.	1
Natural variantⁱVAR_023254	793	P → L2 PublicationsCorresponds to variant dbSNP:rs2230131Ensembl.	1
Natural variantⁱVAR_057262	808	P → S. Corresponds to variant dbSNP:rs3743640Ensembl.	1
Natural variantⁱVAR_023255	816	R → H1 PublicationCorresponds to variant dbSNP:rs4150176Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_038086	1 – 409	Missing in isoform 5. 1 PublicationAdd BLAST	409
Alternative sequenceⁱVSP_038087	1 – 332	Missing in isoform 4. 1 PublicationAdd BLAST	332
Alternative sequenceⁱVSP_015153	1 – 67	Missing in isoform 2. 1 PublicationAdd BLAST	67
Alternative sequenceⁱVSP_015154	280 – 306	SKALI…HPSSA → T in isoform 2 and isoform 6. 2 PublicationsAdd BLAST	27
Alternative sequenceⁱVSP_015156	521	Missing in isoform 2. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L39059 mRNA Translation: AAA62861.1 AK299060 mRNA Translation: BAH12941.1 AK299347 mRNA Translation: BAH13010.1 AK304261 mRNA Translation: BAH14144.1 AK315982 mRNA Translation: BAH14353.1 AB209594 mRNA Translation: BAD92831.1 Sequence problems. AY158985 Genomic DNA Translation: AAN38818.1 AC009123 Genomic DNA No translation available. BC028131 mRNA Translation: AAH28131.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32496.1 [Q15572-1] CCDS45535.1 [Q15572-2] CCDS58488.1 [Q15572-4] CCDS58489.1 [Q15572-6]
PIRⁱ	A55384
NCBI Reference Sequences More...RefSeqⁱ	NP_001230085.1, NM_001243156.1 NP_001230086.1, NM_001243157.1 [Q15572-4] NP_001230087.1, NM_001243158.1 [Q15572-4] NP_001230088.1, NM_001243159.1 [Q15572-5] NP_005670.3, NM_005679.3 NP_647610.2, NM_139353.2 XP_005256283.1, XM_005256226.3 [Q15572-1] XP_016879334.1, XM_017023845.1 [Q15572-6] XP_016879337.1, XM_017023848.1 [Q15572-4]
UniGeneⁱ	Hs.153022

Genome annotation databases

Ensemblⁱ	ENST00000341690; ENSP00000345305; ENSG00000103168 [Q15572-2] ENST00000541676; ENSP00000437900; ENSG00000103168 [Q15572-4] ENST00000566732; ENSP00000455933; ENSG00000103168 [Q15572-6] ENST00000567759; ENSP00000455265; ENSG00000103168 [Q15572-1] ENST00000570117; ENSP00000455247; ENSG00000103168 [Q15572-4]
GeneIDⁱ	9013
KEGGⁱ	hsa:9013
UCSC genome browser More...UCSCⁱ	uc002fhm.4 human [Q15572-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C (Fragment)		HUMAN		146	UniRef100_Q15572
Isoform 5 of TATA box-binding protein-associated factor RNA polymerase I subunit C		HUMAN		460
TATA box-binding protein-associated factor RNA polymerase I subunit C (Fragment)		HUMAN		93
Isoform 4 of TATA box-binding protein-associated factor RNA polymerase I subunit C		HUMAN		537
UPI0003EAF681		HUMAN		870
+1

Protein	Similar proteins		Species	Score	Length	Source
Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C (Fragment)		HUMAN		146	UniRef90_Q15572
TAF1C isoform 5		PANTR		869
TATA-box binding protein associated factor, RNA polymerase I subunit C		PANPA		869
TATA-box binding protein associated factor, RNA polymerase I subunit C		GORGO		869
Isoform 5 of TATA box-binding protein-associated factor RNA polymerase I subunit C		HUMAN		460
+14
Q15572-2	Isoform 6 of TATA box-binding protein-associated factor RNA polymerase I subunit C		HUMAN		843	UniRef90_Q15572-6
TATA-box binding protein associated factor, RNA polymerase I subunit C		CERAT		857
TATA-box binding protein associated factor, RNA polymerase I subunit C		PONAB		844
TATA-box binding protein associated factor, RNA polymerase I subunit C		PAPAN		844
TATA-box binding protein associated factor, RNA polymerase I subunit C		CHLSB		843
+51
Q15572-6	TATA-box binding protein associated factor, RNA polymerase I subunit C		CERAT		857	UniRef90_Q15572-6
TATA-box binding protein associated factor, RNA polymerase I subunit C		PONAB		844
TATA-box binding protein associated factor, RNA polymerase I subunit C		PAPAN		844
TATA-box binding protein associated factor, RNA polymerase I subunit C		CHLSB		843
TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1		MACMU		843
+51

Protein	Similar proteins		Species	Score	Length	Source
Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C (Fragment)		HUMAN		146	UniRef50_Q15572
TAF1C isoform 5		PANTR		869
TATA-box binding protein associated factor, RNA polymerase I subunit C		PANPA		869
TATA-box binding protein associated factor, RNA polymerase I subunit C		GORGO		869
TATA box-binding protein-associated factor RNA polymerase I subunit C isoform X2		Enhydra lutris kenyoni		864
+63
Q15572-2	Isoform 6 of TATA box-binding protein-associated factor RNA polymerase I subunit C		HUMAN		843	UniRef50_Q15572-6
TATA box-binding protein-associated factor, RNA polymerase I, subunit C		RAT		842
TATA box-binding protein-associated factor RNA polymerase I subunit C		MOUSE		836
TATA-box binding protein associated factor, RNA polymerase I subunit C		CERAT		857
TATA-box binding protein associated factor, RNA polymerase I subunit C		PAPAN		844
+166
Q15572-6	TATA box-binding protein-associated factor, RNA polymerase I, subunit C		RAT		842	UniRef50_Q15572-6
TATA box-binding protein-associated factor RNA polymerase I subunit C		MOUSE		836
TATA-box binding protein associated factor, RNA polymerase I subunit C		CERAT		857
TATA-box binding protein associated factor, RNA polymerase I subunit C		PAPAN		844
TATA-box binding protein associated factor, RNA polymerase I subunit C		PONAB		844
+166

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L39059 mRNA Translation: AAA62861.1 AK299060 mRNA Translation: BAH12941.1 AK299347 mRNA Translation: BAH13010.1 AK304261 mRNA Translation: BAH14144.1 AK315982 mRNA Translation: BAH14353.1 AB209594 mRNA Translation: BAD92831.1 Sequence problems. AY158985 Genomic DNA Translation: AAN38818.1 AC009123 Genomic DNA No translation available. BC028131 mRNA Translation: AAH28131.1
CCDSⁱ	CCDS32496.1 [Q15572-1] CCDS45535.1 [Q15572-2] CCDS58488.1 [Q15572-4] CCDS58489.1 [Q15572-6]
PIRⁱ	A55384
RefSeqⁱ	NP_001230085.1, NM_001243156.1 NP_001230086.1, NM_001243157.1 [Q15572-4] NP_001230087.1, NM_001243158.1 [Q15572-4] NP_001230088.1, NM_001243159.1 [Q15572-5] NP_005670.3, NM_005679.3 NP_647610.2, NM_139353.2 XP_005256283.1, XM_005256226.3 [Q15572-1] XP_016879334.1, XM_017023845.1 [Q15572-6] XP_016879337.1, XM_017023848.1 [Q15572-4]
UniGeneⁱ	Hs.153022

3D structure databases

ProteinModelPortalⁱ	Q15572
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114482, 43 interactors
CORUMⁱ	Q15572
DIPⁱ	DIP-269N
IntActⁱ	Q15572, 13 interactors
MINTⁱ	Q15572
STRINGⁱ	9606.ENSP00000367802

PTM databases

iPTMnetⁱ	Q15572
PhosphoSitePlusⁱ	Q15572

Polymorphism and mutation databases

BioMutaⁱ	TAF1C
DMDMⁱ	313104019

Proteomic databases

EPDⁱ	Q15572
MaxQBⁱ	Q15572
PaxDbⁱ	Q15572
PeptideAtlasⁱ	Q15572
PRIDEⁱ	Q15572
ProteomicsDBⁱ	60638 60639 [Q15572-2] 60640 [Q15572-4] 60641 [Q15572-5] 60642 [Q15572-6]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9013
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000341690; ENSP00000345305; ENSG00000103168 [Q15572-2] ENST00000541676; ENSP00000437900; ENSG00000103168 [Q15572-4] ENST00000566732; ENSP00000455933; ENSG00000103168 [Q15572-6] ENST00000567759; ENSP00000455265; ENSG00000103168 [Q15572-1] ENST00000570117; ENSP00000455247; ENSG00000103168 [Q15572-4]
GeneIDⁱ	9013
KEGGⁱ	hsa:9013
UCSCⁱ	uc002fhm.4 human [Q15572-1]

Organism-specific databases

CTDⁱ	9013
DisGeNETⁱ	9013
EuPathDBⁱ	HostDB:ENSG00000103168.16
GeneCardsⁱ	TAF1C
H-InvDBⁱ	HIX0013290
HGNCⁱ	HGNC:11534 TAF1C
HPAⁱ	HPA072229
MIMⁱ	604905 gene
neXtProtⁱ	NX_Q15572
OpenTargetsⁱ	ENSG00000103168
PharmGKBⁱ	PA36309
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH3X Eukaryota ENOG41101B7 LUCA
GeneTreeⁱ	ENSGT00390000010767
HOVERGENⁱ	HBG079499
InParanoidⁱ	Q15572
KOⁱ	K15214
OMAⁱ	LKWNHGL
OrthoDBⁱ	EOG091G09D1
PhylomeDBⁱ	Q15572
TreeFamⁱ	TF351959

Enzyme and pathway databases

Reactomeⁱ	R-HSA-427359 SIRT1 negatively regulates rRNA expression R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-73772 RNA Polymerase I Promoter Escape R-HSA-73777 RNA Polymerase I Chain Elongation R-HSA-73863 RNA Polymerase I Transcription Termination

Reactomeⁱ

R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination

Miscellaneous databases

GeneWikiⁱ	TAF1C
GenomeRNAiⁱ	9013
Protein Ontology More...PROⁱ	PR:Q15572
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000103168 Expressed in 196 organ(s), highest expression level in myometrium
CleanExⁱ	HS_TAF1C
ExpressionAtlasⁱ	Q15572 baseline and differential
Genevisibleⁱ	Q15572 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR038801 TAF1C IPR015943 WD40/YVTN_repeat-like_dom_sf IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR15319 PTHR15319, 2 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAF1C_HUMAN
Accessionⁱ	Q15572Primary (citable) accession number: Q15572 Secondary accession number(s): B7Z5K5 , B7Z5S4, B7Z908, B7Z9L7, Q59F67, Q8N6V3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
	Last sequence update:	November 30, 2010
	Last modified:	September 12, 2018
	This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

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UniProtKB - Q15572 (TAF1C_HUMAN)

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TATA box-binding protein-associated factor RNA polymerase I subunit C

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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Sequence databases

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Proteomic databases

Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ