UniProtKB - Q15572 (TAF1C_HUMAN)
TATA box-binding protein-associated factor RNA polymerase I subunit C
TAF1C
Functioni
GO - Molecular functioni
- RNA polymerase I core promoter sequence-specific DNA binding Source: UniProtKB
- RNA polymerase I general transcription initiation factor activity Source: ARUK-UCL
GO - Biological processi
- positive regulation of gene expression, epigenetic Source: Reactome
- termination of RNA polymerase I transcription Source: Reactome
- transcription by RNA polymerase I Source: ProtInc
- transcription by RNA polymerase II Source: ProtInc
- transcription initiation from RNA polymerase I promoter Source: Reactome
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q15572 |
Reactomei | R-HSA-427359, SIRT1 negatively regulates rRNA expression R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-73863, RNA Polymerase I Transcription Termination |
Names & Taxonomyi
Protein namesi | Recommended name: TATA box-binding protein-associated factor RNA polymerase I subunit CAlternative name(s): RNA polymerase I-specific TBP-associated factor 110 kDa Short name: TAFI110 TATA box-binding protein-associated factor 1C Short name: TBP-associated factor 1C Transcription initiation factor SL1/TIF-IB subunit C |
Gene namesi | Name:TAF1C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11534, TAF1C |
MIMi | 604905, gene |
neXtProti | NX_Q15572 |
VEuPathDBi | HostDB:ENSG00000103168.16 |
Subcellular locationi
Nucleus
Nucleus
- fibrillar center Source: HPA
- nucleolus Source: ParkinsonsUK-UCL
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9013 |
OpenTargetsi | ENSG00000103168 |
PharmGKBi | PA36309 |
Miscellaneous databases
Pharosi | Q15572, Tbio |
Genetic variation databases
BioMutai | TAF1C |
DMDMi | 313104019 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118863 | 1 – 869 | TATA box-binding protein-associated factor RNA polymerase I subunit CAdd BLAST | 869 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 834 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 848 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15572 |
jPOSTi | Q15572 |
MassIVEi | Q15572 |
MaxQBi | Q15572 |
PaxDbi | Q15572 |
PeptideAtlasi | Q15572 |
PRIDEi | Q15572 |
ProteomicsDBi | 60638 [Q15572-1] 60639 [Q15572-2] 60640 [Q15572-4] 60641 [Q15572-5] 60642 [Q15572-6] |
PTM databases
iPTMneti | Q15572 |
PhosphoSitePlusi | Q15572 |
Expressioni
Gene expression databases
Bgeei | ENSG00000103168, Expressed in left lobe of thyroid gland and 208 other tissues |
ExpressionAtlasi | Q15572, baseline and differential |
Genevisiblei | Q15572, HS |
Organism-specific databases
HPAi | ENSG00000103168, Low tissue specificity |
Interactioni
Subunit structurei
Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
Interacts with MYC and RRN3.
Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription.
4 PublicationsBinary interactionsi
Hide detailsQ15572
With | #Exp. | IntAct |
---|---|---|
SET [Q01105] | 4 | EBI-2510659,EBI-1053182 |
TAF12 [Q16514] | 2 | EBI-2510659,EBI-1034238 |
TBP [P20226] | 3 | EBI-2510659,EBI-355371 |
Protein-protein interaction databases
BioGRIDi | 114482, 49 interactors |
CORUMi | Q15572 |
DIPi | DIP-269N |
IntActi | Q15572, 26 interactors |
MINTi | Q15572 |
STRINGi | 9606.ENSP00000455265 |
Miscellaneous databases
RNActi | Q15572, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502QTCT, Eukaryota |
GeneTreei | ENSGT00390000010767 |
HOGENOMi | CLU_037918_0_0_1 |
InParanoidi | Q15572 |
OMAi | LTQEPWA |
OrthoDBi | 372910at2759 |
PhylomeDBi | Q15572 |
TreeFami | TF351959 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR038801, TAF1C IPR015943, WD40/YVTN_repeat-like_dom_sf IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR15319, PTHR15319, 1 hit |
SUPFAMi | SSF50978, SSF50978, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL
60 70 80 90 100
HVTKDLLWEP ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV
110 120 130 140 150
LDVTEQISRF LLDHGDVAFA PLGKLMLENF KLEGAGSRTK KKTVVSVKKL
160 170 180 190 200
LQDLGGHQPW GCPWAYLSNR QRRFSILGGP ILGTSVASHL AELLHEELVL
210 220 230 240 250
RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL HFQEVVLTPG
260 270 280 290 300
DNPQFLGKPG RIQLQGPVRQ VVTCTVQGES KALIYTFLPH WLTCYLTPGP
310 320 330 340 350
FHPSSALLAV RSDYHCAVWK FGKQWQPTLL QAMQVEKGAT GISLSPHLPG
360 370 380 390 400
ELAICSRSGA VCLWSPEDGL RQIYRDPETL VFRDSSSWRW ADFTAHPRVL
410 420 430 440 450
TVGDRTGVKM LDTQGPPGCG LLLFRLGAEA SCQKGERVLL TQYLGHSSPK
460 470 480 490 500
CLPPTLHLVC TQFSLYLVDE RLPLVPMLKW NHGLPSPLLL ARLLPPPRPS
510 520 530 540 550
CVQPLLLGGQ GGQLQLLHLA GEGASVPRLA GPPQSLPSRI DSLPAFPLLE
560 570 580 590 600
PKIQWRLQER LKAPTIGLAA VVPPLPSAPT PGLVLFQLSA AGDVFYQQLR
610 620 630 640 650
PQVDSSLRRD AGPPGDTQPD CHAPTASWTS QDTAGCSQWL KALLKVPLAP
660 670 680 690 700
PVWTAPTFTH RQMLGSTELR REEEEGQRLG VLRKAMARGQ LLLQRDLGSL
710 720 730 740 750
PAAEPPPAPE SGLEDKLSER LGEAWAGRGA AWWERQQGRT SEPGRQTRRP
760 770 780 790 800
KRRTQLSSSF SLSGHVDPSE DTSSPHSPEW PPADALPLPP TTPPSQELTP
810 820 830 840 850
DACAQGVPSE QRQMLRDYMA KLPPQRDTPG CATTPPHSQA SSVRATRSQQ
860
HTPVLSSSQP LRKKPRMGF
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BR71 | H3BR71_HUMAN | TATA box-binding protein-associated... | TAF1C | 380 | Annotation score: | ||
H3BQH8 | H3BQH8_HUMAN | TATA box-binding protein-associated... | TAF1C | 58 | Annotation score: | ||
H3BUZ7 | H3BUZ7_HUMAN | TATA box-binding protein-associated... | TAF1C | 136 | Annotation score: | ||
H3BQZ8 | H3BQZ8_HUMAN | TATA box-binding protein-associated... | TAF1C | 93 | Annotation score: | ||
H3BNH3 | H3BNH3_HUMAN | TATA box-binding protein-associated... | TAF1C | 146 | Annotation score: | ||
H3BR91 | H3BR91_HUMAN | TATA box-binding protein-associated... | TAF1C | 209 | Annotation score: | ||
H3BTQ6 | H3BTQ6_HUMAN | TATA box-binding protein-associated... | TAF1C | 70 | Annotation score: | ||
H3BMQ4 | H3BMQ4_HUMAN | TATA box-binding protein-associated... | TAF1C | 52 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 244 | E → K in BAH13010 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 481 | N → S in BAH14353 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 777 | S → G in BAH14144 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058966 | 91 | C → Y4 PublicationsCorresponds to variant dbSNP:rs4782591Ensembl. | 1 | |
Natural variantiVAR_023245 | 304 | S → F1 PublicationCorresponds to variant dbSNP:rs4150145Ensembl. | 1 | |
Natural variantiVAR_023246 | 357 | R → H1 PublicationCorresponds to variant dbSNP:rs4150147Ensembl. | 1 | |
Natural variantiVAR_023247 | 387 | S → L1 PublicationCorresponds to variant dbSNP:rs4150151Ensembl. | 1 | |
Natural variantiVAR_023248 | 518 | H → Y1 PublicationCorresponds to variant dbSNP:rs4150165Ensembl. | 1 | |
Natural variantiVAR_057261 | 523 | G → R. Corresponds to variant dbSNP:rs4150167Ensembl. | 1 | |
Natural variantiVAR_023249 | 573 | P → L1 PublicationCorresponds to variant dbSNP:rs4150170Ensembl. | 1 | |
Natural variantiVAR_023250 | 575 | L → M3 PublicationsCorresponds to variant dbSNP:rs2230129Ensembl. | 1 | |
Natural variantiVAR_023251 | 591 | A → G1 PublicationCorresponds to variant dbSNP:rs4150172Ensembl. | 1 | |
Natural variantiVAR_023252 | 635 | G → S1 PublicationCorresponds to variant dbSNP:rs4150173Ensembl. | 1 | |
Natural variantiVAR_023253 | 791 | T → M1 PublicationCorresponds to variant dbSNP:rs4150175Ensembl. | 1 | |
Natural variantiVAR_023254 | 793 | P → L2 PublicationsCorresponds to variant dbSNP:rs2230131Ensembl. | 1 | |
Natural variantiVAR_057262 | 808 | P → S. Corresponds to variant dbSNP:rs3743640Ensembl. | 1 | |
Natural variantiVAR_023255 | 816 | R → H1 PublicationCorresponds to variant dbSNP:rs4150176Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038086 | 1 – 409 | Missing in isoform 5. 1 PublicationAdd BLAST | 409 | |
Alternative sequenceiVSP_038087 | 1 – 332 | Missing in isoform 4. 1 PublicationAdd BLAST | 332 | |
Alternative sequenceiVSP_015153 | 1 – 67 | Missing in isoform 2. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_015154 | 280 – 306 | SKALI…HPSSA → T in isoform 2 and isoform 6. 2 PublicationsAdd BLAST | 27 | |
Alternative sequenceiVSP_015156 | 521 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L39059 mRNA Translation: AAA62861.1 AK299060 mRNA Translation: BAH12941.1 AK299347 mRNA Translation: BAH13010.1 AK304261 mRNA Translation: BAH14144.1 AK315982 mRNA Translation: BAH14353.1 AB209594 mRNA Translation: BAD92831.1 Sequence problems. AY158985 Genomic DNA Translation: AAN38818.1 AC009123 Genomic DNA No translation available. BC028131 mRNA Translation: AAH28131.1 |
CCDSi | CCDS32496.1 [Q15572-1] CCDS45535.1 [Q15572-2] CCDS58488.1 [Q15572-4] CCDS58489.1 [Q15572-6] |
PIRi | A55384 |
RefSeqi | NP_001230085.1, NM_001243156.1 [Q15572-6] NP_001230086.1, NM_001243157.1 [Q15572-4] NP_001230087.1, NM_001243158.1 [Q15572-4] NP_001230088.1, NM_001243159.1 [Q15572-5] NP_005670.3, NM_005679.3 [Q15572-1] NP_647610.2, NM_139353.2 [Q15572-2] XP_005256283.1, XM_005256226.3 [Q15572-1] XP_016879334.1, XM_017023845.1 [Q15572-6] XP_016879337.1, XM_017023848.1 |
Genome annotation databases
Ensembli | ENST00000341690; ENSP00000345305; ENSG00000103168 [Q15572-2] ENST00000541676; ENSP00000437900; ENSG00000103168 [Q15572-4] ENST00000566732; ENSP00000455933; ENSG00000103168 [Q15572-6] ENST00000567759; ENSP00000455265; ENSG00000103168 [Q15572-1] ENST00000570117; ENSP00000455247; ENSG00000103168 [Q15572-4] |
GeneIDi | 9013 |
KEGGi | hsa:9013 |
UCSCi | uc002fhm.4, human [Q15572-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L39059 mRNA Translation: AAA62861.1 AK299060 mRNA Translation: BAH12941.1 AK299347 mRNA Translation: BAH13010.1 AK304261 mRNA Translation: BAH14144.1 AK315982 mRNA Translation: BAH14353.1 AB209594 mRNA Translation: BAD92831.1 Sequence problems. AY158985 Genomic DNA Translation: AAN38818.1 AC009123 Genomic DNA No translation available. BC028131 mRNA Translation: AAH28131.1 |
CCDSi | CCDS32496.1 [Q15572-1] CCDS45535.1 [Q15572-2] CCDS58488.1 [Q15572-4] CCDS58489.1 [Q15572-6] |
PIRi | A55384 |
RefSeqi | NP_001230085.1, NM_001243156.1 [Q15572-6] NP_001230086.1, NM_001243157.1 [Q15572-4] NP_001230087.1, NM_001243158.1 [Q15572-4] NP_001230088.1, NM_001243159.1 [Q15572-5] NP_005670.3, NM_005679.3 [Q15572-1] NP_647610.2, NM_139353.2 [Q15572-2] XP_005256283.1, XM_005256226.3 [Q15572-1] XP_016879334.1, XM_017023845.1 [Q15572-6] XP_016879337.1, XM_017023848.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114482, 49 interactors |
CORUMi | Q15572 |
DIPi | DIP-269N |
IntActi | Q15572, 26 interactors |
MINTi | Q15572 |
STRINGi | 9606.ENSP00000455265 |
PTM databases
iPTMneti | Q15572 |
PhosphoSitePlusi | Q15572 |
Genetic variation databases
BioMutai | TAF1C |
DMDMi | 313104019 |
Proteomic databases
EPDi | Q15572 |
jPOSTi | Q15572 |
MassIVEi | Q15572 |
MaxQBi | Q15572 |
PaxDbi | Q15572 |
PeptideAtlasi | Q15572 |
PRIDEi | Q15572 |
ProteomicsDBi | 60638 [Q15572-1] 60639 [Q15572-2] 60640 [Q15572-4] 60641 [Q15572-5] 60642 [Q15572-6] |
Protocols and materials databases
Antibodypediai | 17054, 146 antibodies |
DNASUi | 9013 |
Genome annotation databases
Ensembli | ENST00000341690; ENSP00000345305; ENSG00000103168 [Q15572-2] ENST00000541676; ENSP00000437900; ENSG00000103168 [Q15572-4] ENST00000566732; ENSP00000455933; ENSG00000103168 [Q15572-6] ENST00000567759; ENSP00000455265; ENSG00000103168 [Q15572-1] ENST00000570117; ENSP00000455247; ENSG00000103168 [Q15572-4] |
GeneIDi | 9013 |
KEGGi | hsa:9013 |
UCSCi | uc002fhm.4, human [Q15572-1] |
Organism-specific databases
CTDi | 9013 |
DisGeNETi | 9013 |
GeneCardsi | TAF1C |
HGNCi | HGNC:11534, TAF1C |
HPAi | ENSG00000103168, Low tissue specificity |
MIMi | 604905, gene |
neXtProti | NX_Q15572 |
OpenTargetsi | ENSG00000103168 |
PharmGKBi | PA36309 |
VEuPathDBi | HostDB:ENSG00000103168.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTCT, Eukaryota |
GeneTreei | ENSGT00390000010767 |
HOGENOMi | CLU_037918_0_0_1 |
InParanoidi | Q15572 |
OMAi | LTQEPWA |
OrthoDBi | 372910at2759 |
PhylomeDBi | Q15572 |
TreeFami | TF351959 |
Enzyme and pathway databases
PathwayCommonsi | Q15572 |
Reactomei | R-HSA-427359, SIRT1 negatively regulates rRNA expression R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-73863, RNA Polymerase I Transcription Termination |
Miscellaneous databases
BioGRID-ORCSi | 9013, 675 hits in 1008 CRISPR screens |
GeneWikii | TAF1C |
GenomeRNAii | 9013 |
Pharosi | Q15572, Tbio |
PROi | PR:Q15572 |
RNActi | Q15572, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103168, Expressed in left lobe of thyroid gland and 208 other tissues |
ExpressionAtlasi | Q15572, baseline and differential |
Genevisiblei | Q15572, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR038801, TAF1C IPR015943, WD40/YVTN_repeat-like_dom_sf IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR15319, PTHR15319, 1 hit |
SUPFAMi | SSF50978, SSF50978, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAF1C_HUMAN | |
Accessioni | Q15572Primary (citable) accession number: Q15572 Secondary accession number(s): B7Z5K5 Q8N6V3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | November 30, 2010 | |
Last modified: | April 7, 2021 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot