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UniProtKB - Q15572 (TAF1C_HUMAN)

Entry version 162 (02 Jun 2021)
Sequence version 2 (30 Nov 2010)
Previous versions | rss
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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit C

Gene

TAF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15572

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-427359, SIRT1 negatively regulates rRNA expression
R-HSA-427413, NoRC negatively regulates rRNA expression
R-HSA-5250924, B-WICH complex positively regulates rRNA expression
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-73772, RNA Polymerase I Promoter Escape
R-HSA-73863, RNA Polymerase I Transcription Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit C
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 110 kDa
Short name:
TAFI110
TATA box-binding protein-associated factor 1C
Short name:
TBP-associated factor 1C
Transcription initiation factor SL1/TIF-IB subunit C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF1C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11534, TAF1C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604905, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15572

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000103168.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9013

Open Targets

More...OpenTargetsi		ENSG00000103168

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36309

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15572, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TAF1C

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104019

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001188631 – 869TATA box-binding protein-associated factor RNA polymerase I subunit CAdd BLAST869

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei834PhosphothreonineCombined sources1
Modified residuei848PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15572

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15572

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15572

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15572

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15572

PeptideAtlas

More...PeptideAtlasi		Q15572

PRoteomics IDEntifications database

More...PRIDEi		Q15572

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60638 [Q15572-1]
60639 [Q15572-2]
60640 [Q15572-4]
60641 [Q15572-5]
60642 [Q15572-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15572

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15572

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103168, Expressed in left lobe of thyroid gland and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15572, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15572, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000103168, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.

Interacts with MYC and RRN3.

Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114482, 49 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15572

Database of interacting proteins

More...DIPi		DIP-269N

Protein interaction database and analysis system

More...IntActi		Q15572, 26 interactors

Molecular INTeraction database

More...MINTi		Q15572

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000455265

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15572, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni605 – 629DisorderedSequence analysisAdd BLAST25
Regioni729 – 869DisorderedSequence analysisAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi753 – 776Polar residuesSequence analysisAdd BLAST24
Compositional biasi780 – 796Pro residuesSequence analysisAdd BLAST17
Compositional biasi831 – 859Polar residuesSequence analysisAdd BLAST29

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTCT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010767

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_037918_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15572

Identification of Orthologs from Complete Genome Data

More...OMAi		LTQEPWA

Database of Orthologous Groups

More...OrthoDBi		372910at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15572

TreeFam database of animal gene trees

More...TreeFami		TF351959

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038801, TAF1C
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR15319, PTHR15319, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978, SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15572-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL 
        60         70         80         90        100
HVTKDLLWEP ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV 
       110        120        130        140        150
LDVTEQISRF LLDHGDVAFA PLGKLMLENF KLEGAGSRTK KKTVVSVKKL 
       160        170        180        190        200
LQDLGGHQPW GCPWAYLSNR QRRFSILGGP ILGTSVASHL AELLHEELVL 
       210        220        230        240        250
RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL HFQEVVLTPG 
       260        270        280        290        300
DNPQFLGKPG RIQLQGPVRQ VVTCTVQGES KALIYTFLPH WLTCYLTPGP 
       310        320        330        340        350
FHPSSALLAV RSDYHCAVWK FGKQWQPTLL QAMQVEKGAT GISLSPHLPG 
       360        370        380        390        400
ELAICSRSGA VCLWSPEDGL RQIYRDPETL VFRDSSSWRW ADFTAHPRVL 
       410        420        430        440        450
TVGDRTGVKM LDTQGPPGCG LLLFRLGAEA SCQKGERVLL TQYLGHSSPK 
       460        470        480        490        500
CLPPTLHLVC TQFSLYLVDE RLPLVPMLKW NHGLPSPLLL ARLLPPPRPS 
       510        520        530        540        550
CVQPLLLGGQ GGQLQLLHLA GEGASVPRLA GPPQSLPSRI DSLPAFPLLE 
       560        570        580        590        600
PKIQWRLQER LKAPTIGLAA VVPPLPSAPT PGLVLFQLSA AGDVFYQQLR 
       610        620        630        640        650
PQVDSSLRRD AGPPGDTQPD CHAPTASWTS QDTAGCSQWL KALLKVPLAP 
       660        670        680        690        700
PVWTAPTFTH RQMLGSTELR REEEEGQRLG VLRKAMARGQ LLLQRDLGSL 
       710        720        730        740        750
PAAEPPPAPE SGLEDKLSER LGEAWAGRGA AWWERQQGRT SEPGRQTRRP 
       760        770        780        790        800
KRRTQLSSSF SLSGHVDPSE DTSSPHSPEW PPADALPLPP TTPPSQELTP 
       810        820        830        840        850
DACAQGVPSE QRQMLRDYMA KLPPQRDTPG CATTPPHSQA SSVRATRSQQ 
       860 
HTPVLSSSQP LRKKPRMGF
Length:869
Mass (Da):95,213
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AAFAF296D98A5DB
GO
Isoform 2 (identifier: Q15572-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T
     521-521: Missing.

Show »
Length:775
Mass (Da):84,985
Checksum:i29B8C09D7F9228EF
GO
Isoform 4 (identifier: Q15572-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.

Show »
Length:537
Mass (Da):58,441
Checksum:i6C36809B5E6D2203
GO
Isoform 5 (identifier: Q15572-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.

Show »
Length:460
Mass (Da):49,946
Checksum:iDBE3CAD1F8541D45
GO
Isoform 6 (identifier: Q15572-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T

Show »
Length:843
Mass (Da):92,284
Checksum:i75D245B40F7E9948
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR71H3BR71_HUMAN
TATA box-binding protein-associated...
TAF1C
380Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQH8H3BQH8_HUMAN
TATA box-binding protein-associated...
TAF1C
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUZ7H3BUZ7_HUMAN
TATA box-binding protein-associated...
TAF1C
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNH3H3BNH3_HUMAN
TATA box-binding protein-associated...
TAF1C
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQZ8H3BQZ8_HUMAN
TATA box-binding protein-associated...
TAF1C
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR91H3BR91_HUMAN
TATA box-binding protein-associated...
TAF1C
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTQ6H3BTQ6_HUMAN
TATA box-binding protein-associated...
TAF1C
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMQ4H3BMQ4_HUMAN
TATA box-binding protein-associated...
TAF1C
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92831 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244E → K in BAH13010 (PubMed:14702039).Curated1
Sequence conflicti481N → S in BAH14353 (PubMed:14702039).Curated1
Sequence conflicti777S → G in BAH14144 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05896691C → Y4 PublicationsCorresponds to variant dbSNP:rs4782591Ensembl.1
Natural variantiVAR_023245304S → F1 PublicationCorresponds to variant dbSNP:rs4150145Ensembl.1
Natural variantiVAR_023246357R → H1 PublicationCorresponds to variant dbSNP:rs4150147Ensembl.1
Natural variantiVAR_023247387S → L1 PublicationCorresponds to variant dbSNP:rs4150151Ensembl.1
Natural variantiVAR_023248518H → Y1 PublicationCorresponds to variant dbSNP:rs4150165Ensembl.1
Natural variantiVAR_057261523G → R. Corresponds to variant dbSNP:rs4150167Ensembl.1
Natural variantiVAR_023249573P → L1 PublicationCorresponds to variant dbSNP:rs4150170Ensembl.1
Natural variantiVAR_023250575L → M3 PublicationsCorresponds to variant dbSNP:rs2230129Ensembl.1
Natural variantiVAR_023251591A → G1 PublicationCorresponds to variant dbSNP:rs4150172Ensembl.1
Natural variantiVAR_023252635G → S1 PublicationCorresponds to variant dbSNP:rs4150173Ensembl.1
Natural variantiVAR_023253791T → M1 PublicationCorresponds to variant dbSNP:rs4150175Ensembl.1
Natural variantiVAR_023254793P → L2 PublicationsCorresponds to variant dbSNP:rs2230131Ensembl.1
Natural variantiVAR_057262808P → S. Corresponds to variant dbSNP:rs3743640Ensembl.1
Natural variantiVAR_023255816R → H1 PublicationCorresponds to variant dbSNP:rs4150176Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0380861 – 409Missing in isoform 5. 1 PublicationAdd BLAST409
Alternative sequenceiVSP_0380871 – 332Missing in isoform 4. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_0151531 – 67Missing in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_015154280 – 306SKALI…HPSSA → T in isoform 2 and isoform 6. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_015156521Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L39059 mRNA Translation: AAA62861.1
AK299060 mRNA Translation: BAH12941.1
AK299347 mRNA Translation: BAH13010.1
AK304261 mRNA Translation: BAH14144.1
AK315982 mRNA Translation: BAH14353.1
AB209594 mRNA Translation: BAD92831.1 Sequence problems.
AY158985 Genomic DNA Translation: AAN38818.1
AC009123 Genomic DNA No translation available.
BC028131 mRNA Translation: AAH28131.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32496.1 [Q15572-1]
CCDS45535.1 [Q15572-2]
CCDS58488.1 [Q15572-4]
CCDS58489.1 [Q15572-6]

Protein sequence database of the Protein Information Resource

More...PIRi		A55384

NCBI Reference Sequences

More...RefSeqi		NP_001230085.1, NM_001243156.1 [Q15572-6]
NP_001230086.1, NM_001243157.1 [Q15572-4]
NP_001230087.1, NM_001243158.1 [Q15572-4]
NP_001230088.1, NM_001243159.1 [Q15572-5]
NP_005670.3, NM_005679.3 [Q15572-1]
NP_647610.2, NM_139353.2 [Q15572-2]
XP_005256283.1, XM_005256226.3 [Q15572-1]
XP_016879334.1, XM_017023845.1 [Q15572-6]
XP_016879337.1, XM_017023848.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341690; ENSP00000345305; ENSG00000103168 [Q15572-2]
ENST00000541676; ENSP00000437900; ENSG00000103168 [Q15572-4]
ENST00000566732; ENSP00000455933; ENSG00000103168 [Q15572-6]
ENST00000567759; ENSP00000455265; ENSG00000103168 [Q15572-1]
ENST00000570117; ENSP00000455247; ENSG00000103168 [Q15572-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9013

UCSC genome browser

More...UCSCi		uc002fhm.4, human [Q15572-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39059 mRNA Translation: AAA62861.1
AK299060 mRNA Translation: BAH12941.1
AK299347 mRNA Translation: BAH13010.1
AK304261 mRNA Translation: BAH14144.1
AK315982 mRNA Translation: BAH14353.1
AB209594 mRNA Translation: BAD92831.1 Sequence problems.
AY158985 Genomic DNA Translation: AAN38818.1
AC009123 Genomic DNA No translation available.
BC028131 mRNA Translation: AAH28131.1
CCDSiCCDS32496.1 [Q15572-1]
CCDS45535.1 [Q15572-2]
CCDS58488.1 [Q15572-4]
CCDS58489.1 [Q15572-6]
PIRiA55384
RefSeqiNP_001230085.1, NM_001243156.1 [Q15572-6]
NP_001230086.1, NM_001243157.1 [Q15572-4]
NP_001230087.1, NM_001243158.1 [Q15572-4]
NP_001230088.1, NM_001243159.1 [Q15572-5]
NP_005670.3, NM_005679.3 [Q15572-1]
NP_647610.2, NM_139353.2 [Q15572-2]
XP_005256283.1, XM_005256226.3 [Q15572-1]
XP_016879334.1, XM_017023845.1 [Q15572-6]
XP_016879337.1, XM_017023848.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi114482, 49 interactors
CORUMiQ15572
DIPiDIP-269N
IntActiQ15572, 26 interactors
MINTiQ15572
STRINGi9606.ENSP00000455265

PTM databases

iPTMnetiQ15572
PhosphoSitePlusiQ15572

Genetic variation databases

BioMutaiTAF1C
DMDMi313104019

Proteomic databases

EPDiQ15572
jPOSTiQ15572
MassIVEiQ15572
MaxQBiQ15572
PaxDbiQ15572
PeptideAtlasiQ15572
PRIDEiQ15572
ProteomicsDBi60638 [Q15572-1]
60639 [Q15572-2]
60640 [Q15572-4]
60641 [Q15572-5]
60642 [Q15572-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17054, 147 antibodies

The DNASU plasmid repository

More...DNASUi		9013

Genome annotation databases

EnsembliENST00000341690; ENSP00000345305; ENSG00000103168 [Q15572-2]
ENST00000541676; ENSP00000437900; ENSG00000103168 [Q15572-4]
ENST00000566732; ENSP00000455933; ENSG00000103168 [Q15572-6]
ENST00000567759; ENSP00000455265; ENSG00000103168 [Q15572-1]
ENST00000570117; ENSP00000455247; ENSG00000103168 [Q15572-4]
GeneIDi9013
KEGGihsa:9013
UCSCiuc002fhm.4, human [Q15572-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9013
DisGeNETi9013

GeneCards: human genes, protein and diseases

More...GeneCardsi		TAF1C
HGNCiHGNC:11534, TAF1C
HPAiENSG00000103168, Low tissue specificity
MIMi604905, gene
neXtProtiNX_Q15572
OpenTargetsiENSG00000103168
PharmGKBiPA36309
VEuPathDBiHostDB:ENSG00000103168.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTCT, Eukaryota
GeneTreeiENSGT00390000010767
HOGENOMiCLU_037918_0_0_1
InParanoidiQ15572
OMAiLTQEPWA
OrthoDBi372910at2759
PhylomeDBiQ15572
TreeFamiTF351959

Enzyme and pathway databases

PathwayCommonsiQ15572
ReactomeiR-HSA-427359, SIRT1 negatively regulates rRNA expression
R-HSA-427413, NoRC negatively regulates rRNA expression
R-HSA-5250924, B-WICH complex positively regulates rRNA expression
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-73772, RNA Polymerase I Promoter Escape
R-HSA-73863, RNA Polymerase I Transcription Termination

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9013, 675 hits in 1008 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TAF1C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9013
PharosiQ15572, Tbio

Protein Ontology

More...PROi		PR:Q15572
RNActiQ15572, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000103168, Expressed in left lobe of thyroid gland and 208 other tissues
ExpressionAtlasiQ15572, baseline and differential
GenevisibleiQ15572, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR038801, TAF1C
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR15319, PTHR15319, 1 hit
SUPFAMiSSF50978, SSF50978, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF1C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15572
Secondary accession number(s): B7Z5K5
, B7Z5S4, B7Z908, B7Z9L7, Q59F67, Q8N6V3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 30, 2010
Last modified: June 2, 2021
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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