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Entry version 154 (11 Dec 2019)
Sequence version 2 (30 Nov 2010)
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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit C

Gene

TAF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73863 RNA Polymerase I Transcription Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit C
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 110 kDa
Short name:
TAFI110
TATA box-binding protein-associated factor 1C
Short name:
TBP-associated factor 1C
Transcription initiation factor SL1/TIF-IB subunit C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF1C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103168.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11534 TAF1C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604905 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15572

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9013

Open Targets

More...
OpenTargetsi
ENSG00000103168

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36309

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15572 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAF1C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104019

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001188631 – 869TATA box-binding protein-associated factor RNA polymerase I subunit CAdd BLAST869

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei834PhosphothreonineCombined sources1
Modified residuei848PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15572

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15572

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q15572

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15572

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15572

PeptideAtlas

More...
PeptideAtlasi
Q15572

PRoteomics IDEntifications database

More...
PRIDEi
Q15572

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60638 [Q15572-1]
60639 [Q15572-2]
60640 [Q15572-4]
60641 [Q15572-5]
60642 [Q15572-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15572

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15572

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103168 Expressed in 196 organ(s), highest expression level in myometrium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15572 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15572 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA072229

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.

Interacts with MYC and RRN3.

Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114482, 45 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q15572

Database of interacting proteins

More...
DIPi
DIP-269N

Protein interaction database and analysis system

More...
IntActi
Q15572, 25 interactors

Molecular INTeraction database

More...
MINTi
Q15572

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000455265

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q15572 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15572

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH3X Eukaryota
ENOG41101B7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010767

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15572

KEGG Orthology (KO)

More...
KOi
K15214

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSSWRWA

Database of Orthologous Groups

More...
OrthoDBi
372910at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15572

TreeFam database of animal gene trees

More...
TreeFami
TF351959

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038801 TAF1C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15319 PTHR15319, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15572-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL
60 70 80 90 100
HVTKDLLWEP ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV
110 120 130 140 150
LDVTEQISRF LLDHGDVAFA PLGKLMLENF KLEGAGSRTK KKTVVSVKKL
160 170 180 190 200
LQDLGGHQPW GCPWAYLSNR QRRFSILGGP ILGTSVASHL AELLHEELVL
210 220 230 240 250
RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL HFQEVVLTPG
260 270 280 290 300
DNPQFLGKPG RIQLQGPVRQ VVTCTVQGES KALIYTFLPH WLTCYLTPGP
310 320 330 340 350
FHPSSALLAV RSDYHCAVWK FGKQWQPTLL QAMQVEKGAT GISLSPHLPG
360 370 380 390 400
ELAICSRSGA VCLWSPEDGL RQIYRDPETL VFRDSSSWRW ADFTAHPRVL
410 420 430 440 450
TVGDRTGVKM LDTQGPPGCG LLLFRLGAEA SCQKGERVLL TQYLGHSSPK
460 470 480 490 500
CLPPTLHLVC TQFSLYLVDE RLPLVPMLKW NHGLPSPLLL ARLLPPPRPS
510 520 530 540 550
CVQPLLLGGQ GGQLQLLHLA GEGASVPRLA GPPQSLPSRI DSLPAFPLLE
560 570 580 590 600
PKIQWRLQER LKAPTIGLAA VVPPLPSAPT PGLVLFQLSA AGDVFYQQLR
610 620 630 640 650
PQVDSSLRRD AGPPGDTQPD CHAPTASWTS QDTAGCSQWL KALLKVPLAP
660 670 680 690 700
PVWTAPTFTH RQMLGSTELR REEEEGQRLG VLRKAMARGQ LLLQRDLGSL
710 720 730 740 750
PAAEPPPAPE SGLEDKLSER LGEAWAGRGA AWWERQQGRT SEPGRQTRRP
760 770 780 790 800
KRRTQLSSSF SLSGHVDPSE DTSSPHSPEW PPADALPLPP TTPPSQELTP
810 820 830 840 850
DACAQGVPSE QRQMLRDYMA KLPPQRDTPG CATTPPHSQA SSVRATRSQQ
860
HTPVLSSSQP LRKKPRMGF
Length:869
Mass (Da):95,213
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AAFAF296D98A5DB
GO
Isoform 2 (identifier: Q15572-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T
     521-521: Missing.

Show »
Length:775
Mass (Da):84,985
Checksum:i29B8C09D7F9228EF
GO
Isoform 4 (identifier: Q15572-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.

Show »
Length:537
Mass (Da):58,441
Checksum:i6C36809B5E6D2203
GO
Isoform 5 (identifier: Q15572-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.

Show »
Length:460
Mass (Da):49,946
Checksum:iDBE3CAD1F8541D45
GO
Isoform 6 (identifier: Q15572-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T

Show »
Length:843
Mass (Da):92,284
Checksum:i75D245B40F7E9948
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR71H3BR71_HUMAN
TATA box-binding protein-associated...
TAF1C
380Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQZ8H3BQZ8_HUMAN
TATA box-binding protein-associated...
TAF1C
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQH8H3BQH8_HUMAN
TATA box-binding protein-associated...
TAF1C
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNH3H3BNH3_HUMAN
TATA box-binding protein-associated...
TAF1C
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR91H3BR91_HUMAN
TATA box-binding protein-associated...
TAF1C
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUZ7H3BUZ7_HUMAN
TATA box-binding protein-associated...
TAF1C
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMQ4H3BMQ4_HUMAN
TATA box-binding protein-associated...
TAF1C
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTQ6H3BTQ6_HUMAN
TATA box-binding protein-associated...
TAF1C
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92831 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244E → K in BAH13010 (PubMed:14702039).Curated1
Sequence conflicti481N → S in BAH14353 (PubMed:14702039).Curated1
Sequence conflicti777S → G in BAH14144 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05896691C → Y4 PublicationsCorresponds to variant dbSNP:rs4782591Ensembl.1
Natural variantiVAR_023245304S → F1 PublicationCorresponds to variant dbSNP:rs4150145Ensembl.1
Natural variantiVAR_023246357R → H1 PublicationCorresponds to variant dbSNP:rs4150147Ensembl.1
Natural variantiVAR_023247387S → L1 PublicationCorresponds to variant dbSNP:rs4150151Ensembl.1
Natural variantiVAR_023248518H → Y1 PublicationCorresponds to variant dbSNP:rs4150165Ensembl.1
Natural variantiVAR_057261523G → R. Corresponds to variant dbSNP:rs4150167Ensembl.1
Natural variantiVAR_023249573P → L1 PublicationCorresponds to variant dbSNP:rs4150170Ensembl.1
Natural variantiVAR_023250575L → M3 PublicationsCorresponds to variant dbSNP:rs2230129EnsemblClinVar.1
Natural variantiVAR_023251591A → G1 PublicationCorresponds to variant dbSNP:rs4150172Ensembl.1
Natural variantiVAR_023252635G → S1 PublicationCorresponds to variant dbSNP:rs4150173Ensembl.1
Natural variantiVAR_023253791T → M1 PublicationCorresponds to variant dbSNP:rs4150175Ensembl.1
Natural variantiVAR_023254793P → L2 PublicationsCorresponds to variant dbSNP:rs2230131Ensembl.1
Natural variantiVAR_057262808P → S. Corresponds to variant dbSNP:rs3743640Ensembl.1
Natural variantiVAR_023255816R → H1 PublicationCorresponds to variant dbSNP:rs4150176Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0380861 – 409Missing in isoform 5. 1 PublicationAdd BLAST409
Alternative sequenceiVSP_0380871 – 332Missing in isoform 4. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_0151531 – 67Missing in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_015154280 – 306SKALI…HPSSA → T in isoform 2 and isoform 6. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_015156521Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L39059 mRNA Translation: AAA62861.1
AK299060 mRNA Translation: BAH12941.1
AK299347 mRNA Translation: BAH13010.1
AK304261 mRNA Translation: BAH14144.1
AK315982 mRNA Translation: BAH14353.1
AB209594 mRNA Translation: BAD92831.1 Sequence problems.
AY158985 Genomic DNA Translation: AAN38818.1
AC009123 Genomic DNA No translation available.
BC028131 mRNA Translation: AAH28131.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32496.1 [Q15572-1]
CCDS45535.1 [Q15572-2]
CCDS58488.1 [Q15572-4]
CCDS58489.1 [Q15572-6]

Protein sequence database of the Protein Information Resource

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PIRi
A55384

NCBI Reference Sequences

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RefSeqi
NP_001230085.1, NM_001243156.1 [Q15572-6]
NP_001230086.1, NM_001243157.1 [Q15572-4]
NP_001230087.1, NM_001243158.1 [Q15572-4]
NP_001230088.1, NM_001243159.1 [Q15572-5]
NP_005670.3, NM_005679.3 [Q15572-1]
NP_647610.2, NM_139353.2 [Q15572-2]
XP_005256283.1, XM_005256226.3 [Q15572-1]
XP_016879334.1, XM_017023845.1 [Q15572-6]
XP_016879337.1, XM_017023848.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000341690; ENSP00000345305; ENSG00000103168 [Q15572-2]
ENST00000541676; ENSP00000437900; ENSG00000103168 [Q15572-4]
ENST00000566732; ENSP00000455933; ENSG00000103168 [Q15572-6]
ENST00000567759; ENSP00000455265; ENSG00000103168 [Q15572-1]
ENST00000570117; ENSP00000455247; ENSG00000103168 [Q15572-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9013

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9013

UCSC genome browser

More...
UCSCi
uc002fhm.4 human [Q15572-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39059 mRNA Translation: AAA62861.1
AK299060 mRNA Translation: BAH12941.1
AK299347 mRNA Translation: BAH13010.1
AK304261 mRNA Translation: BAH14144.1
AK315982 mRNA Translation: BAH14353.1
AB209594 mRNA Translation: BAD92831.1 Sequence problems.
AY158985 Genomic DNA Translation: AAN38818.1
AC009123 Genomic DNA No translation available.
BC028131 mRNA Translation: AAH28131.1
CCDSiCCDS32496.1 [Q15572-1]
CCDS45535.1 [Q15572-2]
CCDS58488.1 [Q15572-4]
CCDS58489.1 [Q15572-6]
PIRiA55384
RefSeqiNP_001230085.1, NM_001243156.1 [Q15572-6]
NP_001230086.1, NM_001243157.1 [Q15572-4]
NP_001230087.1, NM_001243158.1 [Q15572-4]
NP_001230088.1, NM_001243159.1 [Q15572-5]
NP_005670.3, NM_005679.3 [Q15572-1]
NP_647610.2, NM_139353.2 [Q15572-2]
XP_005256283.1, XM_005256226.3 [Q15572-1]
XP_016879334.1, XM_017023845.1 [Q15572-6]
XP_016879337.1, XM_017023848.1

3D structure databases

SMRiQ15572
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114482, 45 interactors
CORUMiQ15572
DIPiDIP-269N
IntActiQ15572, 25 interactors
MINTiQ15572
STRINGi9606.ENSP00000455265

PTM databases

iPTMnetiQ15572
PhosphoSitePlusiQ15572

Polymorphism and mutation databases

BioMutaiTAF1C
DMDMi313104019

Proteomic databases

EPDiQ15572
jPOSTiQ15572
MassIVEiQ15572
MaxQBiQ15572
PaxDbiQ15572
PeptideAtlasiQ15572
PRIDEiQ15572
ProteomicsDBi60638 [Q15572-1]
60639 [Q15572-2]
60640 [Q15572-4]
60641 [Q15572-5]
60642 [Q15572-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9013

Genome annotation databases

EnsembliENST00000341690; ENSP00000345305; ENSG00000103168 [Q15572-2]
ENST00000541676; ENSP00000437900; ENSG00000103168 [Q15572-4]
ENST00000566732; ENSP00000455933; ENSG00000103168 [Q15572-6]
ENST00000567759; ENSP00000455265; ENSG00000103168 [Q15572-1]
ENST00000570117; ENSP00000455247; ENSG00000103168 [Q15572-4]
GeneIDi9013
KEGGihsa:9013
UCSCiuc002fhm.4 human [Q15572-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9013
DisGeNETi9013
EuPathDBiHostDB:ENSG00000103168.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TAF1C
HGNCiHGNC:11534 TAF1C
HPAiHPA072229
MIMi604905 gene
neXtProtiNX_Q15572
OpenTargetsiENSG00000103168
PharmGKBiPA36309

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH3X Eukaryota
ENOG41101B7 LUCA
GeneTreeiENSGT00390000010767
InParanoidiQ15572
KOiK15214
OMAiPSSWRWA
OrthoDBi372910at2759
PhylomeDBiQ15572
TreeFamiTF351959

Enzyme and pathway databases

ReactomeiR-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73863 RNA Polymerase I Transcription Termination

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TAF1C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9013
PharosiQ15572 Tbio

Protein Ontology

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PROi
PR:Q15572
RNActiQ15572 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103168 Expressed in 196 organ(s), highest expression level in myometrium
ExpressionAtlasiQ15572 baseline and differential
GenevisibleiQ15572 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR038801 TAF1C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR15319 PTHR15319, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF1C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15572
Secondary accession number(s): B7Z5K5
, B7Z5S4, B7Z908, B7Z9L7, Q59F67, Q8N6V3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 30, 2010
Last modified: December 11, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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