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UniProtKB - Q15561 (TEAD4_HUMAN)

Entry version 180 (17 Jun 2020)
Sequence version 3 (25 Nov 2008)
Previous versions | rss
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Protein

Transcriptional enhancer factor TEF-3

Gene

TEAD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi36 – 112TEAPROSITE-ProRule annotationAdd BLAST77

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15561

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-3
Alternative name(s):
TEA domain family member 4
Short name:
TEAD-4
Transcription factor 13-like 1
Transcription factor RTEF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TEAD4
Synonyms:RTEF1, TCF13L1, TEF3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000197905.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:11717 TEAD4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601714 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15561

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi266D → A: Reduced transforming ability. 1 Publication1
Mutagenesisi297K → A: Important loss of interaction with YAP1 and complete loss of transforming ability. 1 Publication1
Mutagenesisi299W → A: Important loss of interaction with YAP1 and complete loss of transforming ability. 1 Publication1
Mutagenesisi337F → A: Reduced interaction with YAP1. 1 Publication1
Mutagenesisi373F → A: Reduced transforming ability. 1 Publication1
Mutagenesisi380L → A: Reduced transforming ability. 1 Publication1
Mutagenesisi391E → A: Reduced transforming ability. 1 Publication1
Mutagenesisi393F → A: Reduced transforming ability. 1 Publication1
Mutagenesisi427H → A: Reduced transforming ability. 1 Publication1
Mutagenesisi429Y → A or H: Loss of interaction with YAP1 and also activation by YAP1. 2 Publications1
Mutagenesisi429Y → A: Important loss of interaction with YAP1 and complete loss of transforming ability. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		7004

Open Targets

More...OpenTargetsi		ENSG00000197905

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36435

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15561 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295828

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TEAD4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002059371 – 434Transcriptional enhancer factor TEF-3Add BLAST434

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15561

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15561

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15561

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15561

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15561

PeptideAtlas

More...PeptideAtlasi		Q15561

PRoteomics IDEntifications database

More...PRIDEi		Q15561

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		34410
60634 [Q15561-1]
60635 [Q15561-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15561

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15561

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q15561

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197905 Expressed in gastrocnemius and 171 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15561 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15561 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197905 Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q15561
With#Exp.IntAct
CCDC125 [Q86Z20]3EBI-747736,EBI-11977221
CCDC172 [P0C7W6]3EBI-747736,EBI-2548868
CDR2 [Q01850]3EBI-747736,EBI-1181367
CEP55 [Q53EZ4]5EBI-747736,EBI-747776
DYDC1 [Q8WWB3]3EBI-747736,EBI-740680
GOLGA2 [Q08379]6EBI-747736,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-747736,EBI-5916454
HAUS1 [Q96CS2]3EBI-747736,EBI-2514791
HOMEZ - isoform 2 [Q8IX15-3]3EBI-747736,EBI-10172004
INCA1 [Q0VD86]3EBI-747736,EBI-6509505
KRT27 [Q7Z3Y8]3EBI-747736,EBI-3044087
KRT31 [Q15323]3EBI-747736,EBI-948001
KRT40 [Q6A162]6EBI-747736,EBI-10171697
LDOC1 [O95751]3EBI-747736,EBI-740738
LZTS2 [Q9BRK4]3EBI-747736,EBI-741037
MTUS2 - isoform 2 [Q5JR59-3]6EBI-747736,EBI-11522433
PNMA1 [Q8ND90]3EBI-747736,EBI-302345
PRDM14 [Q9GZV8]3EBI-747736,EBI-3957793
PRKAR1B [P31321]3EBI-747736,EBI-2805516
RASSF10 [A6NK89]3EBI-747736,EBI-6912267
RUNDC3A - isoform 3 [Q59EK9-3]3EBI-747736,EBI-11957366
RUNX1 - isoform AML-1G [Q01196-8]5EBI-747736,EBI-12001422
SAT1 [P21673]3EBI-747736,EBI-711613
SESTD1 [Q86VW0]3EBI-747736,EBI-6117072
SORBS3 [O60504]3EBI-747736,EBI-741237
TLE5 - isoform 2 [Q08117-2]3EBI-747736,EBI-11741437
TRAF1 [Q13077]6EBI-747736,EBI-359224
TRIM27 [P14373]6EBI-747736,EBI-719493
TRIM54 [Q9BYV2]3EBI-747736,EBI-2130429
VGLL1 [Q99990]3EBI-747736,EBI-11983165
VGLL3 - isoform 2 [A8MV65-2]3EBI-747736,EBI-11957216
VGLL4 [Q14135]3EBI-747736,EBI-5278589
VPS52 [Q8N1B4]3EBI-747736,EBI-2799833
VTA1 [Q9NP79]4EBI-747736,EBI-740160
WWTR1 [Q9GZV5]9EBI-747736,EBI-747743
YAP1 [P46937]10EBI-747736,EBI-1044059
Vgll4 [Q80V24] from Mus musculus.3EBI-747736,EBI-9253433

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112863, 45 interactors

Database of interacting proteins

More...DIPi		DIP-61626N

Protein interaction database and analysis system

More...IntActi		Q15561, 48 interactors

Molecular INTeraction database

More...MINTi		Q15561

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352926

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15561 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1434
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15561

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3841 Eukaryota
ENOG410XQMP LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182956

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012515_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15561

KEGG Orthology (KO)

More...KOi		K09448

Database of Orthologous Groups

More...OrthoDBi		823827at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15561

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1610, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000818 TEA/ATTS_dom
IPR038096 TEA/ATTS_sf
IPR027255 TEF-3
IPR016361 TEF_metazoa
IPR041086 YBD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01285 TEA, 1 hit
PF17725 YBD, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002603 TEF, 1 hit
PIRSF500722 TEF-3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00065 TEADOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00426 TEA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00554 TEA_1, 1 hit
PS51088 TEA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15561-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGTAGTITS NEWSSPTSPE GSTASGGSQA LDKPIDNDAE GVWSPDIEQS 
        60         70         80         90        100
FQEALAIYPP CGRRKIILSD EGKMYGRNEL IARYIKLRTG KTRTRKQVSS 
       110        120        130        140        150
HIQVLARRKA REIQAKLKDQ AAKDKALQSM AAMSSAQIIS ATAFHSSMAL 
       160        170        180        190        200
ARGPGRPAVS GFWQGALPGQ AGTSHDVKPF SQQTYAVQPP LPLPGFESPA 
       210        220        230        240        250
GPAPSPSAPP APPWQGRSVA SSKLWMLEFS AFLEQQQDPD TYNKHLFVHI 
       260        270        280        290        300
GQSSPSYSDP YLEAVDIRQI YDKFPEKKGG LKDLFERGPS NAFFLVKFWA 
       310        320        330        340        350
DLNTNIEDEG SSFYGVSSQY ESPENMIITC STKVCSFGKQ VVEKVETEYA 
       360        370        380        390        400
RYENGHYSYR IHRSPLCEYM INFIHKLKHL PEKYMMNSVL ENFTILQVVT 
       410        420        430 
NRDTQETLLC IAYVFEVSAS EHGAQHHIYR LVKE
Length:434
Mass (Da):48,329
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i544DDFD86E88D9A8
GO
Isoform 2 (identifier: Q15561-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.

Show »
Length:305
Mass (Da):34,158
Checksum:i6A3BDF596BCE7797
GO
Isoform 3 (identifier: Q15561-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-161: Missing.

Show »
Length:391
Mass (Da):44,058
Checksum:i68B36C4E607ADB1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q53GI4Q53GI4_HUMAN
TEA domain family member 4 isoform ...
TEAD4
434Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRF3A0A0A0MRF3_HUMAN
Transcriptional enhancer factor TEF...
TEAD4
391Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YG62H0YG62_HUMAN
Transcriptional enhancer factor TEF...
TEAD4
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGS2H0YGS2_HUMAN
Transcriptional enhancer factor TEF...
TEAD4
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7B0H0Y7B0_HUMAN
Transcriptional enhancer factor TEF...
TEAD4
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFF9H0YFF9_HUMAN
Transcriptional enhancer factor TEF...
TEAD4
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFK0H0YFK0_HUMAN
Transcriptional enhancer factor TEF...
TEAD4
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA64212 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39A → G in AAC50763 (PubMed:8921372).Curated1
Sequence conflicti149A → R in AAC50763 (PubMed:8921372).Curated1
Sequence conflicti172G → E in AAC50763 (PubMed:8921372).Curated1
Sequence conflicti218 – 220SVA → RRG in AAC50763 (PubMed:8921372).Curated3
Sequence conflicti258 – 259SD → LR in AAC50763 (PubMed:8921372).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052279323P → S. Corresponds to variant dbSNP:rs11550887Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430991 – 129Missing in isoform 2. 1 PublicationAdd BLAST129
Alternative sequenceiVSP_045657119 – 161Missing in isoform 3. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U63824 mRNA Translation: AAC50763.1
BX640921 mRNA Translation: CAE45959.1
AC005911 Genomic DNA No translation available.
AC125807 Genomic DNA No translation available.
AC131234 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88872.1
BC015497 mRNA Translation: AAH15497.2
X94438 mRNA Translation: CAA64212.2 Sequence problems.
AY101179 mRNA Translation: AAM89497.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31729.1 [Q15561-1]
CCDS31730.1 [Q15561-3]
CCDS41737.1 [Q15561-2]

NCBI Reference Sequences

More...RefSeqi		NP_003204.2, NM_003213.3 [Q15561-1]
NP_958849.1, NM_201441.2 [Q15561-3]
NP_958851.1, NM_201443.2 [Q15561-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000397122; ENSP00000380311; ENSG00000197905 [Q15561-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7004

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7004

UCSC genome browser

More...UCSCi		uc001qln.4 human [Q15561-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63824 mRNA Translation: AAC50763.1
BX640921 mRNA Translation: CAE45959.1
AC005911 Genomic DNA No translation available.
AC125807 Genomic DNA No translation available.
AC131234 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88872.1
BC015497 mRNA Translation: AAH15497.2
X94438 mRNA Translation: CAA64212.2 Sequence problems.
AY101179 mRNA Translation: AAM89497.1
CCDSiCCDS31729.1 [Q15561-1]
CCDS31730.1 [Q15561-3]
CCDS41737.1 [Q15561-2]
RefSeqiNP_003204.2, NM_003213.3 [Q15561-1]
NP_958849.1, NM_201441.2 [Q15561-3]
NP_958851.1, NM_201443.2 [Q15561-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GZBX-ray2.70A36-139[»]
5NO6X-ray2.88I/N40-112[»]
5OAQX-ray1.95A217-434[»]
6GE3X-ray1.85A216-434[»]
6GE4X-ray1.97A216-434[»]
6GE5X-ray2.05A216-434[»]
6GE6X-ray1.80A216-434[»]
6GECX-ray1.70A216-434[»]
6GEEX-ray1.96A216-434[»]
6GEGX-ray2.23A216-434[»]
6GEIX-ray1.65A216-434[»]
6GEKX-ray2.28A/B216-434[»]
6HIKX-ray1.65A216-434[»]
6Q2XX-ray2.10A217-434[»]
6Q36X-ray2.01A/B217-434[»]
6SENX-ray1.65A/B217-434[»]
6SEOX-ray2.55A217-434[»]
SMRiQ15561
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112863, 45 interactors
DIPiDIP-61626N
IntActiQ15561, 48 interactors
MINTiQ15561
STRINGi9606.ENSP00000352926

Chemistry databases

ChEMBLiCHEMBL4295828

PTM databases

iPTMnetiQ15561
PhosphoSitePlusiQ15561
SwissPalmiQ15561

Polymorphism and mutation databases

BioMutaiTEAD4

Proteomic databases

EPDiQ15561
jPOSTiQ15561
MassIVEiQ15561
MaxQBiQ15561
PaxDbiQ15561
PeptideAtlasiQ15561
PRIDEiQ15561
ProteomicsDBi34410
60634 [Q15561-1]
60635 [Q15561-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22199 266 antibodies

The DNASU plasmid repository

More...DNASUi		7004

Genome annotation databases

EnsembliENST00000397122; ENSP00000380311; ENSG00000197905 [Q15561-2]
GeneIDi7004
KEGGihsa:7004
UCSCiuc001qln.4 human [Q15561-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7004
DisGeNETi7004
EuPathDBiHostDB:ENSG00000197905.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		TEAD4
HGNCiHGNC:11717 TEAD4
HPAiENSG00000197905 Tissue enhanced (skeletal)
MIMi601714 gene
neXtProtiNX_Q15561
OpenTargetsiENSG00000197905
PharmGKBiPA36435

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3841 Eukaryota
ENOG410XQMP LUCA
GeneTreeiENSGT00950000182956
HOGENOMiCLU_012515_0_0_1
InParanoidiQ15561
KOiK09448
OrthoDBi823827at2759
PhylomeDBiQ15561

Enzyme and pathway databases

ReactomeiR-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
SIGNORiQ15561

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7004 41 hits in 810 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TEAD4 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TEAD4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7004
PharosiQ15561 Tbio

Protein Ontology

More...PROi		PR:Q15561
RNActiQ15561 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197905 Expressed in gastrocnemius and 171 other tissues
ExpressionAtlasiQ15561 baseline and differential
GenevisibleiQ15561 HS

Family and domain databases

Gene3Di1.10.10.1610, 1 hit
InterProiView protein in InterPro
IPR000818 TEA/ATTS_dom
IPR038096 TEA/ATTS_sf
IPR027255 TEF-3
IPR016361 TEF_metazoa
IPR041086 YBD
PfamiView protein in Pfam
PF01285 TEA, 1 hit
PF17725 YBD, 1 hit
PIRSFiPIRSF002603 TEF, 1 hit
PIRSF500722 TEF-3, 1 hit
PRINTSiPR00065 TEADOMAIN
SMARTiView protein in SMART
SM00426 TEA, 1 hit
PROSITEiView protein in PROSITE
PS00554 TEA_1, 1 hit
PS51088 TEA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEAD4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15561
Secondary accession number(s): H0Y308
, Q6MZR9, Q8NEV5, Q92883, Q96BK2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: June 17, 2020
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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