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Protein

Transcription elongation factor A protein 2

Gene

TCEA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.1 Publication

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 297TFIIS-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

  • DNA-templated transcription, elongation Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: Ensembl
  • regulation of DNA-templated transcription, elongation Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein 2
Alternative name(s):
Testis-specific S-II
Transcription elongation factor S-II protein 2
Transcription elongation factor TFIIS.l
Gene namesi
Name:TCEA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000171703.16
HGNCiHGNC:11614 TCEA2
MIMi604784 gene
neXtProtiNX_Q15560

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6919
OpenTargetsiENSG00000171703
PharmGKBiPA36373

Polymorphism and mutation databases

BioMutaiTCEA2
DMDMi28380177

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214491 – 299Transcription elongation factor A protein 2Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei60PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15560
PaxDbiQ15560
PeptideAtlasiQ15560
PRIDEiQ15560
ProteomicsDBi60633

PTM databases

iPTMnetiQ15560
PhosphoSitePlusiQ15560

Expressioni

Tissue specificityi

Testis and ovary specific.1 Publication

Gene expression databases

BgeeiENSG00000171703
CleanExiHS_TCEA2
ExpressionAtlasiQ15560 baseline and differential
GenevisibleiQ15560 HS

Organism-specific databases

HPAiHPA043836

Interactioni

Subunit structurei

Interacts with the basal transcription factor GTF2B. Interacts with REXO1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112781, 61 interactors
IntActiQ15560, 130 interactors
MINTiQ15560
STRINGi9606.ENSP00000343515

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi139 – 151Combined sources13
Helixi155 – 159Combined sources5
Helixi163 – 178Combined sources16
Turni181 – 183Combined sources3
Helixi184 – 197Combined sources14
Beta strandi199 – 202Combined sources4
Helixi203 – 209Combined sources7
Helixi215 – 220Combined sources6
Helixi223 – 227Combined sources5
Turni229 – 233Combined sources5
Beta strandi235 – 237Combined sources3

3D structure databases

ProteinModelPortaliQ15560
SMRiQ15560
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 83TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini138 – 254TFIIS centralPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Belongs to the TFS-II family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 297TFIIS-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1105 Eukaryota
COG1594 LUCA
GeneTreeiENSGT00390000017794
HOGENOMiHOG000195015
HOVERGENiHBG055022
InParanoidiQ15560
KOiK03145
OMAiEFKSTDM
OrthoDBiEOG091G10EJ
PhylomeDBiQ15560
TreeFamiTF314970

Family and domain databases

Gene3Di1.10.472.30, 1 hit
1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035100 TF_IIS-typ
IPR003617 TFIIS/CRSP70_N_sub
IPR035441 TFIIS/LEDGF_dom_sf
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR017923 TFIIS_N
IPR006289 TFSII
IPR001222 Znf_TFIIS
PfamiView protein in Pfam
PF08711 Med26, 1 hit
PF01096 TFIIS_C, 1 hit
PF07500 TFIIS_M, 1 hit
PIRSFiPIRSF006704 TF_IIS, 1 hit
SMARTiView protein in SMART
SM00510 TFS2M, 1 hit
SM00509 TFS2N, 1 hit
SM00440 ZnF_C2C2, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF47676 SSF47676, 1 hit
TIGRFAMsiTIGR01385 TFSII, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS51319 TFIIS_N, 1 hit
PS00466 ZF_TFIIS_1, 1 hit
PS51133 ZF_TFIIS_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15560-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGKEEEIAR IARRLDKMVT KKSAEGAMDL LRELKAMPIT LHLLQSTRVG
60 70 80 90 100
MSVNALRKQS SDEEVIALAK SLIKSWKKLL DASDAKARER GRGMPLPTSS
110 120 130 140 150
RDASEAPDPS RKRPELPRAP STPRITTFPP VPVTCDAVRN KCREMLTAAL
160 170 180 190 200
QTDHDHVAIG ADCERLSAQI EECIFRDVGN TDMKYKNRVR SRISNLKDAK
210 220 230 240 250
NPDLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK EAIREHQMAR
260 270 280 290
TGGTQTDLFT CGKCRKKNCT YTQVQTRSSD EPMTTFVVCN ECGNRWKFC
Length:299
Mass (Da):33,601
Last modified:November 1, 1996 - v1
Checksum:iFF0EAE8EDC7BCBE9
GO
Isoform 2 (identifier: Q15560-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):30,569
Checksum:iB0023436A8268207
GO

Sequence cautioni

The sequence CAD11900 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAD11901 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55A → T in BAG51383 (PubMed:14702039).Curated1
Sequence conflicti164E → V in BAG51383 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0473451 – 27Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50495 mRNA Translation: BAA09089.1
AK027824 mRNA Translation: BAG51383.1
AL590548 Genomic DNA Translation: CAD11900.1 Sequence problems.
AL590548 Genomic DNA Translation: CAD11901.1 Sequence problems.
BC018896 mRNA Translation: AAH18896.1
U86749 Genomic DNA Translation: AAC39553.1
CCDSiCCDS13553.1 [Q15560-1]
CCDS13554.1 [Q15560-2]
PIRiJC4577
RefSeqiNP_003186.1, NM_003195.5 [Q15560-1]
NP_942016.1, NM_198723.2 [Q15560-2]
XP_016883525.1, XM_017028036.1 [Q15560-2]
XP_016883526.1, XM_017028037.1 [Q15560-2]
UniGeneiHs.505004
Hs.736326

Genome annotation databases

EnsembliENST00000343484; ENSP00000343515; ENSG00000171703 [Q15560-1]
ENST00000361317; ENSP00000354552; ENSG00000171703 [Q15560-2]
GeneIDi6919
KEGGihsa:6919
UCSCiuc061yqt.1 human [Q15560-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTCEA2_HUMAN
AccessioniPrimary (citable) accession number: Q15560
Secondary accession number(s): B3KNM1, Q8TD37, Q8TD38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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