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Entry version 187 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Transcription elongation factor A protein 2

Gene

TCEA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.1 Publication

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri257 – 297TFIIS-typePROSITE-ProRule annotationAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q15560

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription elongation factor A protein 2
Alternative name(s):
Testis-specific S-II
Transcription elongation factor S-II protein 2
Transcription elongation factor TFIIS.l
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCEA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000171703.16

Human Gene Nomenclature Database

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HGNCi
HGNC:11614, TCEA2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604784, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q15560

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
6919

Open Targets

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OpenTargetsi
ENSG00000171703

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36373

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q15560, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TCEA2

Domain mapping of disease mutations (DMDM)

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DMDMi
28380177

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001214491 – 299Transcription elongation factor A protein 2Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15560

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15560

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15560

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15560

PeptideAtlas

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PeptideAtlasi
Q15560

PRoteomics IDEntifications database

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PRIDEi
Q15560

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60633 [Q15560-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15560

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15560

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis and ovary specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000171703, Expressed in right hemisphere of cerebellum and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15560, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15560, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171703, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the basal transcription factor GTF2B.

Interacts with REXO1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q15560
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-710310,EBI-10173507
AGR2 [O95994]3EBI-710310,EBI-712648
AGTRAP - isoform 2 [Q6RW13-2]3EBI-710310,EBI-11522760
ALAS1 [P13196]3EBI-710310,EBI-3905054
AMOTL2 [Q9Y2J4]3EBI-710310,EBI-746752
ARMC10 - isoform 2 [Q8N2F6-2]3EBI-710310,EBI-12902762
AXIN2 [Q9Y2T1]3EBI-710310,EBI-4400025
BACH2 [Q9BYV9]3EBI-710310,EBI-1642333
BHLHB9 [Q6PI77]3EBI-710310,EBI-11519926
BICD2 - isoform 2 [Q8TD16-2]3EBI-710310,EBI-11975051
BOLL - isoform 4 [Q8N9W6-4]3EBI-710310,EBI-11983447
BTBD6 - isoform 2 [Q96KE9-2]3EBI-710310,EBI-12012762
CBY2 - isoform 2 [Q8NA61-2]3EBI-710310,EBI-11524851
CCDC136 - isoform 2 [Q96JN2-2]3EBI-710310,EBI-10171416
CCDC157 [Q569K6]3EBI-710310,EBI-13289565
CEP44 [Q9C0F1]3EBI-710310,EBI-744115
CEP76 [Q8TAP6]3EBI-710310,EBI-742887
CMTM4 - isoform 2 [Q8IZR5-2]3EBI-710310,EBI-17278014
CMTM6 [Q9NX76]3EBI-710310,EBI-1054315
CNTROB [Q8N137]3EBI-710310,EBI-947360
COX20 [Q5RI15]3EBI-710310,EBI-2834035
CYSRT1 [A8MQ03]3EBI-710310,EBI-3867333
DAB1 [O75553]3EBI-710310,EBI-7875264
DES [P17661]3EBI-710310,EBI-1055572
DVL3 [Q92997]3EBI-710310,EBI-739789
EAF1 [Q96JC9]3EBI-710310,EBI-769261
EAF2 [Q96CJ1]3EBI-710310,EBI-1245604
EXOSC8 [Q96B26]3EBI-710310,EBI-371922
FADD [Q13158]3EBI-710310,EBI-494804
FAM9B [Q8IZU0]3EBI-710310,EBI-10175124
FCHO1 [A0A0C3SFZ9]3EBI-710310,EBI-11977403
FXR1 - isoform 2 [P51114-2]3EBI-710310,EBI-11022345
GAS8 [O95995]3EBI-710310,EBI-1052570
GIGYF1 [O75420]3EBI-710310,EBI-947774
GOLGA2 [Q08379]6EBI-710310,EBI-618309
GPKOW [Q92917]7EBI-710310,EBI-746309
GRIPAP1 [Q4V328]3EBI-710310,EBI-717919
HES7 [Q9BYE0]3EBI-710310,EBI-12163087
HIGD1C [A8MV81]3EBI-710310,EBI-12809676
HIP1 [O00291]3EBI-710310,EBI-473886
HMBOX1 [Q6NT76]3EBI-710310,EBI-2549423
HSF2BP [O75031]3EBI-710310,EBI-7116203
IKZF1 - isoform Ik7 [Q13422-7]3EBI-710310,EBI-11522367
IKZF4 [Q9H2S9]3EBI-710310,EBI-1640423
KCNF1 [Q9H3M0]3EBI-710310,EBI-6918743
KCTD10 [Q9H3F6]3EBI-710310,EBI-2505886
KCTD7 - isoform 2 [Q96MP8-2]3EBI-710310,EBI-11954971
KIAA1958 [Q8N8K9]6EBI-710310,EBI-10181113
KRT40 [Q6A162]3EBI-710310,EBI-10171697
KRTAP10-7 [P60409]3EBI-710310,EBI-10172290
KRTAP10-8 [P60410]3EBI-710310,EBI-10171774
KRTAP12-2 [P59991]3EBI-710310,EBI-10176379
KRTAP12-3 [P60328]3EBI-710310,EBI-11953334
KRTAP5-9 [P26371]3EBI-710310,EBI-3958099
KXD1 [Q9BQD3]3EBI-710310,EBI-739657
LIMS1 - isoform 3 [P48059-3]3EBI-710310,EBI-12864460
LZTS1 [Q9Y250]3EBI-710310,EBI-1216080
LZTS2 [Q9BRK4]3EBI-710310,EBI-741037
MAGEA11 [P43364]5EBI-710310,EBI-739552
MARK3 [P27448]2EBI-710310,EBI-707595
MCC [P23508]3EBI-710310,EBI-307531
MDK [P21741]3EBI-710310,EBI-722444
MEOX2 [P50222]3EBI-710310,EBI-748397
MEOX2 [Q6FHY5]3EBI-710310,EBI-16439278
MID2 - isoform 2 [Q9UJV3-2]3EBI-710310,EBI-10172526
MKRN3 [Q13064]3EBI-710310,EBI-2340269
MSANTD4 [Q8NCY6]3EBI-710310,EBI-7850168
MTUS2 - isoform 2 [Q5JR59-3]3EBI-710310,EBI-11522433
NAB2 [Q15742]3EBI-710310,EBI-8641936
NECAB1 [Q8N987]3EBI-710310,EBI-11956853
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-710310,EBI-10172876
OSBPL3 [Q9H4L5]3EBI-710310,EBI-1051317
PIBF1 [Q4G0R1]3EBI-710310,EBI-14066006
PICK1 [Q9NRD5]3EBI-710310,EBI-79165
PIH1D2 [Q8WWB5]3EBI-710310,EBI-10232538
PNMA1 [Q8ND90]3EBI-710310,EBI-302345
PNMA5 [Q96PV4]3EBI-710310,EBI-10171633
POU6F2 [P78424]3EBI-710310,EBI-12029004
PRPH [P41219]3EBI-710310,EBI-752074
RBPMS - isoform C [Q93062-3]3EBI-710310,EBI-740343
RETREG3 [Q86VR2]3EBI-710310,EBI-10192441
SCYL1 - isoform 4 [Q96KG9-4]3EBI-710310,EBI-12023020
SSC5D [A1L4H1]3EBI-710310,EBI-10172867
STAC3 [Q96MF2]3EBI-710310,EBI-745680
STX11 [O75558]3EBI-710310,EBI-714135
SYNE4 - isoform 2 [Q8N205-2]3EBI-710310,EBI-12099160
TARBP2 [Q15633]3EBI-710310,EBI-978581
TAX1BP1 [Q86VP1]3EBI-710310,EBI-529518
TBC1D1 [Q86TI0]3EBI-710310,EBI-1644036
TCF4 [P15884]3EBI-710310,EBI-533224
TEPSIN [Q96N21]3EBI-710310,EBI-11139477
TFCP2 [Q12800]3EBI-710310,EBI-717422
THAP1 [Q9NVV9]6EBI-710310,EBI-741515
TMEM71 - isoform 2 [Q6P5X7-2]3EBI-710310,EBI-12886878
TNIP1 [Q15025]8EBI-710310,EBI-357849
TOX2 - isoform 3 [Q96NM4-3]3EBI-710310,EBI-12815137
TRAF1 [Q13077]3EBI-710310,EBI-359224
TRAF2 [Q12933]7EBI-710310,EBI-355744
TRIM23 [P36406]3EBI-710310,EBI-740098
TRIM27 [P14373]6EBI-710310,EBI-719493
TRIM38 [O00635]3EBI-710310,EBI-2130415
TRIM41 [Q8WV44]3EBI-710310,EBI-725997
TRIM54 [Q9BYV2]6EBI-710310,EBI-2130429
TSGA10 [Q9BZW7]3EBI-710310,EBI-744794
USP54 - isoform 6 [Q70EL1-9]3EBI-710310,EBI-11975223
VIM [P08670]3EBI-710310,EBI-353844
ZBTB22 [O15209]3EBI-710310,EBI-723574
ZBTB43 [O43298]3EBI-710310,EBI-740718
ZBTB8A [Q96BR9]3EBI-710310,EBI-742740
ZBTB9 [Q96C00]3EBI-710310,EBI-395708
ZKSCAN8 [Q15776]3EBI-710310,EBI-2602314
ZNF526 [Q8TF50]3EBI-710310,EBI-11035148
ZRANB1 [Q9UGI0]3EBI-710310,EBI-527853

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
112781, 146 interactors

Protein interaction database and analysis system

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IntActi
Q15560, 129 interactors

Molecular INTeraction database

More...
MINTi
Q15560

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343515

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q15560, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q15560

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15560

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 83TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini138 – 254TFIIS centralPROSITE-ProRule annotationAdd BLAST117

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFS-II family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 297TFIIS-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1105, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000159974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037637_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15560

KEGG Orthology (KO)

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KOi
K03145

Identification of Orthologs from Complete Genome Data

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OMAi
KMVTRKS

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15560

TreeFam database of animal gene trees

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TreeFami
TF314970

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.472.30, 1 hit
1.20.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035100, TF_IIS-typ
IPR003617, TFIIS/CRSP70_N_sub
IPR035441, TFIIS/LEDGF_dom_sf
IPR003618, TFIIS_cen_dom
IPR036575, TFIIS_cen_dom_sf
IPR017923, TFIIS_N
IPR006289, TFSII
IPR001222, Znf_TFIIS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08711, Med26, 1 hit
PF01096, TFIIS_C, 1 hit
PF07500, TFIIS_M, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006704, TF_IIS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00510, TFS2M, 1 hit
SM00509, TFS2N, 1 hit
SM00440, ZnF_C2C2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46942, SSF46942, 1 hit
SSF47676, SSF47676, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01385, TFSII, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51321, TFIIS_CENTRAL, 1 hit
PS51319, TFIIS_N, 1 hit
PS00466, ZF_TFIIS_1, 1 hit
PS51133, ZF_TFIIS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15560-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMGKEEEIAR IARRLDKMVT KKSAEGAMDL LRELKAMPIT LHLLQSTRVG
60 70 80 90 100
MSVNALRKQS SDEEVIALAK SLIKSWKKLL DASDAKARER GRGMPLPTSS
110 120 130 140 150
RDASEAPDPS RKRPELPRAP STPRITTFPP VPVTCDAVRN KCREMLTAAL
160 170 180 190 200
QTDHDHVAIG ADCERLSAQI EECIFRDVGN TDMKYKNRVR SRISNLKDAK
210 220 230 240 250
NPDLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK EAIREHQMAR
260 270 280 290
TGGTQTDLFT CGKCRKKNCT YTQVQTRSSD EPMTTFVVCN ECGNRWKFC
Length:299
Mass (Da):33,601
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF0EAE8EDC7BCBE9
GO
Isoform 2 (identifier: Q15560-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:272
Mass (Da):30,569
Checksum:iB0023436A8268207
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MT58A0A0A0MT58_HUMAN
Transcription elongation factor A p...
TCEA2
270Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JRI7Q5JRI7_HUMAN
Transcription elongation factor A p...
TCEA2
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86VL0Q86VL0_HUMAN
TCEA2 protein
TCEA2 hCG_2021465
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JRI8Q5JRI8_HUMAN
Transcription elongation factor A p...
TCEA2
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55A → T in BAG51383 (PubMed:14702039).Curated1
Sequence conflicti164E → V in BAG51383 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0473451 – 27Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D50495 mRNA Translation: BAA09089.1
AK027824 mRNA Translation: BAG51383.1
AL590548 Genomic DNA No translation available.
BC018896 mRNA Translation: AAH18896.1
U86749 Genomic DNA Translation: AAC39553.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13553.1 [Q15560-1]
CCDS13554.1 [Q15560-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4577

NCBI Reference Sequences

More...
RefSeqi
NP_003186.1, NM_003195.5 [Q15560-1]
NP_942016.1, NM_198723.2 [Q15560-2]
XP_016883525.1, XM_017028036.1
XP_016883526.1, XM_017028037.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343484; ENSP00000343515; ENSG00000171703 [Q15560-1]
ENST00000361317; ENSP00000354552; ENSG00000171703 [Q15560-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6919

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6919

UCSC genome browser

More...
UCSCi
uc061yqt.1, human [Q15560-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50495 mRNA Translation: BAA09089.1
AK027824 mRNA Translation: BAG51383.1
AL590548 Genomic DNA No translation available.
BC018896 mRNA Translation: AAH18896.1
U86749 Genomic DNA Translation: AAC39553.1
CCDSiCCDS13553.1 [Q15560-1]
CCDS13554.1 [Q15560-2]
PIRiJC4577
RefSeqiNP_003186.1, NM_003195.5 [Q15560-1]
NP_942016.1, NM_198723.2 [Q15560-2]
XP_016883525.1, XM_017028036.1
XP_016883526.1, XM_017028037.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LW4NMR-A130-239[»]
BMRBiQ15560
SMRiQ15560
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112781, 146 interactors
IntActiQ15560, 129 interactors
MINTiQ15560
STRINGi9606.ENSP00000343515

PTM databases

iPTMnetiQ15560
PhosphoSitePlusiQ15560

Polymorphism and mutation databases

BioMutaiTCEA2
DMDMi28380177

Proteomic databases

EPDiQ15560
jPOSTiQ15560
MassIVEiQ15560
PaxDbiQ15560
PeptideAtlasiQ15560
PRIDEiQ15560
ProteomicsDBi60633 [Q15560-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
15504, 133 antibodies

The DNASU plasmid repository

More...
DNASUi
6919

Genome annotation databases

EnsembliENST00000343484; ENSP00000343515; ENSG00000171703 [Q15560-1]
ENST00000361317; ENSP00000354552; ENSG00000171703 [Q15560-2]
GeneIDi6919
KEGGihsa:6919
UCSCiuc061yqt.1, human [Q15560-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6919
DisGeNETi6919
EuPathDBiHostDB:ENSG00000171703.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TCEA2
HGNCiHGNC:11614, TCEA2
HPAiENSG00000171703, Low tissue specificity
MIMi604784, gene
neXtProtiNX_Q15560
OpenTargetsiENSG00000171703
PharmGKBiPA36373

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1105, Eukaryota
GeneTreeiENSGT00940000159974
HOGENOMiCLU_037637_2_0_1
InParanoidiQ15560
KOiK03145
OMAiKMVTRKS
PhylomeDBiQ15560
TreeFamiTF314970

Enzyme and pathway databases

PathwayCommonsiQ15560

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
6919, 33 hits in 879 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TCEA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6919
PharosiQ15560, Tbio

Protein Ontology

More...
PROi
PR:Q15560
RNActiQ15560, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171703, Expressed in right hemisphere of cerebellum and 223 other tissues
ExpressionAtlasiQ15560, baseline and differential
GenevisibleiQ15560, HS

Family and domain databases

Gene3Di1.10.472.30, 1 hit
1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035100, TF_IIS-typ
IPR003617, TFIIS/CRSP70_N_sub
IPR035441, TFIIS/LEDGF_dom_sf
IPR003618, TFIIS_cen_dom
IPR036575, TFIIS_cen_dom_sf
IPR017923, TFIIS_N
IPR006289, TFSII
IPR001222, Znf_TFIIS
PfamiView protein in Pfam
PF08711, Med26, 1 hit
PF01096, TFIIS_C, 1 hit
PF07500, TFIIS_M, 1 hit
PIRSFiPIRSF006704, TF_IIS, 1 hit
SMARTiView protein in SMART
SM00510, TFS2M, 1 hit
SM00509, TFS2N, 1 hit
SM00440, ZnF_C2C2, 1 hit
SUPFAMiSSF46942, SSF46942, 1 hit
SSF47676, SSF47676, 1 hit
TIGRFAMsiTIGR01385, TFSII, 1 hit
PROSITEiView protein in PROSITE
PS51321, TFIIS_CENTRAL, 1 hit
PS51319, TFIIS_N, 1 hit
PS00466, ZF_TFIIS_1, 1 hit
PS51133, ZF_TFIIS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCEA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15560
Secondary accession number(s): B3KNM1, Q8TD37, Q8TD38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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