TERF2

Functionⁱ

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	512 – 537	H-T-H motifPROSITE-ProRule annotationAdd BLAST		26

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
double-stranded telomeric DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18812185
- 21852327
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20479256
G-rich strand telomeric DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17694070
protein-containing complex binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 14690602
- 24095731
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12181313
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 9326950
telomeric DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20655466

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterograde axonal transport of messenger ribonucleoprotein complex Source: Ensembl
cell cycle Source: UniProtKB-KW
cellular senescence
Source: BHF-UCL
Non-traceable author statementⁱ
- 17395247
negative regulation of beta-galactosidase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11927518
negative regulation of cellular senescence
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11927518
negative regulation of exonuclease activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15200954
negative regulation of gene expression
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11927518
negative regulation of t-circle formation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15507207
negative regulation of telomere capping
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24270157
negative regulation of telomere maintenance
Source: UniProtKB
Inferred from direct assayⁱ
- 17055345
negative regulation of telomere maintenance via recombination
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15507207
negative regulation of telomere maintenance via semi-conservative replication
Source: BHF-UCL
Non-traceable author statementⁱ
- 15007108
negative regulation of telomere maintenance via telomerase
Source: BHF-UCL
Inferred from direct assayⁱ
- 17055345
negative regulation of telomere maintenance via telomere lengthening
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24012755
negative regulation of telomere single strand break repair
Source: BHF-UCL
Non-traceable author statementⁱ
- 17395247
negative regulation of telomeric D-loop disassembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 15200954
positive regulation of gene expression
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11927518
positive regulation of nitric-oxide synthase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11927518
protection from non-homologous end joining at telomere
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 14690602
- 17499040
protein localization to chromosome, telomeric region
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17499040
regulation of telomere maintenance
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22536324
regulation of telomere maintenance via telomerase
Source: BHF-UCL
Inferred from direct assayⁱ
- 23685356
RNA-dependent DNA biosynthetic process Source: GOC
telomere capping
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
telomere maintenance
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20655466
telomeric D-loop disassembly
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 22039056
telomeric loop formation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10338214

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Cell cycle

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1221632 Meiotic synapsis R-HSA-171306 Packaging Of Telomere Ends R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence

Reactomeⁱ

R-HSA-1221632 Meiotic synapsis
R-HSA-171306 Packaging Of Telomere Ends
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Telomeric repeat-binding factor 2 Alternative name(s): TTAGGG repeat-binding factor 2 Telomeric DNA-binding protein
Gene namesⁱ	Name:TERF2 Synonyms:TRBF2, TRF2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000132604.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11729 TERF2
MIMⁱ	602027 gene
neXtProtⁱ	NX_Q15554

Keywords - Cellular componentⁱ

Chromosome, Nucleus, Telomere

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7014
Open Targets More...OpenTargetsⁱ	ENSG00000132604
PharmGKBⁱ	PA36446

Polymorphism and mutation databases

DMDMⁱ	21542277

DMDMⁱ

21542277

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197131	1 – 542	Telomeric repeat-binding factor 2Add BLAST		542

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	59	Asymmetric dimethylarginine; by PRMT11 Publication	1
Modified residueⁱ	60	Omega-N-methylarginine1 Publication	1
Modified residueⁱ	230	Phosphothreonine; by ATM1 Publication	1
Cross-linkⁱ	287	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	335	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	353	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	365	PhosphoserineCombined sources	1
Cross-linkⁱ	369	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	375	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	452	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Phosphorylated upon DNA damage, most probably by ATM. Phosphorylated TERF2 is not bound to telomeric DNA, and rapidly localizes to damage sites.1 Publication

Methylated by PRMT1 at multiple arginines within the N-terminal Arg-rich region. Methylation may control association with telomeres.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q15554
PaxDbⁱ	Q15554
PeptideAtlas More...PeptideAtlasⁱ	Q15554
PRIDEⁱ	Q15554
ProteomicsDBⁱ	60629

PTM databases

iPTMnetⁱ	Q15554
PhosphoSitePlusⁱ	Q15554

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.

Gene expression databases

Bgeeⁱ	ENSG00000132604 Expressed in 231 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_TERF2
ExpressionAtlasⁱ	Q15554 baseline and differential
Genevisibleⁱ	Q15554 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010451 HPA001907 HPA002735

HPAⁱ

CAB010451
HPA001907
HPA002735

Interactionⁱ

Subunit structureⁱ

Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP/RAP1, ACD and POT1. Interacts with TERF2IP. Interacts with NBN. Interacts with SLX4/BTBD12. Interacts with DCLRE1B/Apollo and TERF2IP/RAP1; the interaction is direct.12 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ATM	Q13315	2	EBI-706637,EBI-495465
BLM	P54132	8	EBI-706637,EBI-621372
CCDC137	Q6PK04	2	EBI-706637,EBI-714654
DCLRE1B	Q9H816	9	EBI-706637,EBI-3508943
DDX21	Q9NR30	2	EBI-706637,EBI-357942
EBNA1	P03211	3	EBI-706637,EBI-996522	From Epstein-Barr virus (strain B95-8).
H2AFX	P16104	4	EBI-706637,EBI-494830
HDGFL2	Q7Z4V5	2	EBI-706637,EBI-1049136
HEXIM1	O94992	2	EBI-706637,EBI-2832510
HMGN2	P05204	2	EBI-706637,EBI-1758689
MCPH1	Q8NEM0	5	EBI-706637,EBI-1565483
NAIF1	Q69YI7	2	EBI-706637,EBI-10249231
ORC1	Q13415	2	EBI-706637,EBI-374847
ORC2	Q13416	3	EBI-706637,EBI-374957
POT1	Q9NUX5	6	EBI-706637,EBI-752420
Ppp1r10	Q80W00	3	EBI-706637,EBI-2553719	From Mus musculus.
RPL13	P26373	2	EBI-706637,EBI-356849
SLX4	Q8IY92	5	EBI-706637,EBI-2370740
TERF2IP	Q9NYB0	36	EBI-706637,EBI-750109
TINF2	Q9BSI4	11	EBI-706637,EBI-717399
TINF2	Q9BSI4-3	4	EBI-706637,EBI-717418
WRN	Q14191	8	EBI-706637,EBI-368417
ZC3H18	Q86VM9	2	EBI-706637,EBI-1045965

GO - Molecular functionⁱ

enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20479256
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12181313
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 9326950

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112873, 270 interactors
ComplexPortalⁱ	CPX-152 Shelterin complex CPX-484 SLX4-TERF2 complex
CORUMⁱ	Q15554
Database of interacting proteins More...DIPⁱ	DIP-34052N
ELMⁱ	Q15554
IntActⁱ	Q15554, 78 interactors
Molecular INTeraction database More...MINTⁱ	Q15554
STRINGⁱ	9606.ENSP00000254942

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	87 – 89	Combined sources	3
Helixⁱ	90 – 111	Combined sources	22
Helixⁱ	115 – 128	Combined sources	14
Helixⁱ	137 – 153	Combined sources	17
Turnⁱ	154 – 156	Combined sources	3
Beta strandⁱ	163 – 165	Combined sources	3
Helixⁱ	170 – 184	Combined sources	15
Helixⁱ	189 – 209	Combined sources	21
Helixⁱ	213 – 223	Combined sources	11
Helixⁱ	228 – 230	Combined sources	3
Helixⁱ	231 – 243	Combined sources	13
Turnⁱ	244 – 246	Combined sources	3
Helixⁱ	249 – 252	Combined sources	4
Helixⁱ	256 – 268	Combined sources	13
Helixⁱ	277 – 285	Combined sources	9
Turnⁱ	286 – 288	Combined sources	3
Helixⁱ	327 – 338	Combined sources	12
Helixⁱ	343 – 352	Combined sources	10
Helixⁱ	401 – 406	Combined sources	6
Turnⁱ	482 – 485	Combined sources	4
Beta strandⁱ	487 – 489	Combined sources	3
Helixⁱ	494 – 507	Combined sources	14
Helixⁱ	512 – 518	Combined sources	7
Helixⁱ	526 – 538	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15554
SMRⁱ	Q15554
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q15554

EvolutionaryTraceⁱ

Q15554

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	484 – 541	HTH myb-typePROSITE-ProRule annotationAdd BLAST		58

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	84 – 287	TRFH dimerizationAdd BLAST		204

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	371 – 375	Nuclear localization signalSequence analysis		5

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	55 – 72	Arg-rich (basic)Add BLAST		18

Domainⁱ

The TRFH dimerization region mediates the interaction with DCLRE1B/Apollo but not TINF2.1 Publication

The HTH domain is an independent structural unit and mediates binding to telomeric DNA.1 Publication

Phylogenomic databases

eggNOGⁱ	ENOG410IJXM Eukaryota ENOG4111KJ3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063796
HOGENOMⁱ	HOG000154547
HOVERGENⁱ	HBG108560
InParanoidⁱ	Q15554
KEGG Orthology (KO) More...KOⁱ	K11111
OMAⁱ	NPKVPKG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04CC
TreeFamⁱ	TF333209

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11654 TRF2_RBM, 1 hit
Gene3Dⁱ	1.25.40.210, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017930 Myb_dom IPR001005 SANT/Myb IPR013867 Telomere_rpt-bd_fac_dimer_dom IPR036507 Telomere_rpt-bd_fac_dimer_sf IPR017357 TERF1/2 IPR030657 TERF2 IPR031902 TERF2_RBM
PANTHERⁱ	PTHR21717:SF13 PTHR21717:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00249 Myb_DNA-binding, 1 hit PF16772 TERF2_RBM, 1 hit PF08558 TRF, 1 hit
PIRSFⁱ	PIRSF038016 Telomere_bd-1_Pin2, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD014243 Telomere_repeat-bd_fac_dimer, 1 hit
SMARTⁱ	View protein in SMART SM00717 SANT, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF63600 SSF63600, 1 hit
PROSITEⁱ	View protein in PROSITE PS51294 HTH_MYB, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15554-3) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGAGTAGP ASGPGVVRDP AASQPRKRPG REGGEGARRS DTMAGGGGSS 
        60         70         80         90        100
DGSGRAAGRR ASRSSGRARR GRHEPGLGGP AERGAGEARL EEAVNRWVLK 
       110        120        130        140        150
FYFHEALRAF RGSRYGDFRQ IRDIMQALLV RPLGKEHTVS RLLRVMQCLS 
       160        170        180        190        200
RIEEGENLDC SFDMEAELTP LESAINVLEM IKTEFTLTEA VVESSRKLVK 
       210        220        230        240        250
EAAVIICIKN KEFEKASKIL KKHMSKDPTT QKLRNDLLNI IREKNLAHPV 
       260        270        280        290        300
IQNFSYETFQ QKMLRFLESH LDDAEPYLLT MAKKALKSES AASSTGKEDK 
       310        320        330        340        350
QPAPGPVEKP PREPARQLRN PPTTIGMMTL KAAFKTLSGA QDSEAAFAKL 
       360        370        380        390        400
DQKDLVLPTQ ALPASPALKN KRPRKDENES SAPADGEGGS ELQPKNKRMT 
       410        420        430        440        450
ISRLVLEEDS QSTEPSAGLN SSQEAASAPP SKPTVLNQPL PGEKNPKVPK 
       460        470        480        490        500
GKWNSSNGVE EKETWVEEDE LFQVQAAPDE DSTTNITKKQ KWTVEESEWV 
       510        520        530        540 
KAGVQKYGEG NWAAISKNYP FVNRTAVMIK DRWRTMKRLG MN

Length:542

Mass (Da):59,594

Last modified:April 16, 2014 - v3

Checksum:ⁱ3A278AC6B594C43A

GO

Isoform 2 (identifier: Q15554-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
281-293: MAKKALKSESAAS → VRLGPSPITMVCP
294-542: Missing.

« Hide

        10         20         30         40         50
MAAGAGTAGP ASGPGVVRDP AASQPRKRPG REGGEGARRS DTMAGGGGSS 
        60         70         80         90        100
DGSGRAAGRR ASRSSGRARR GRHEPGLGGP AERGAGEARL EEAVNRWVLK 
       110        120        130        140        150
FYFHEALRAF RGSRYGDFRQ IRDIMQALLV RPLGKEHTVS RLLRVMQCLS 
       160        170        180        190        200
RIEEGENLDC SFDMEAELTP LESAINVLEM IKTEFTLTEA VVESSRKLVK 
       210        220        230        240        250
EAAVIICIKN KEFEKASKIL KKHMSKDPTT QKLRNDLLNI IREKNLAHPV 
       260        270        280        290 
IQNFSYETFQ QKMLRFLESH LDDAEPYLLT VRLGPSPITM VCP

Note: No experimental confirmation available.

Show »

Length:293

Mass (Da):32,298

Checksum:ⁱF9B31F886F3D3C23

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BR06	H3BR06_HUMAN	Telomeric repeat-binding factor 2 Telomeric repeat-binding factor 2	TERF2	283	Annotation score:
U3KQ35	U3KQ35_HUMAN	Telomeric repeat-binding factor 2 Telomeric repeat-binding factor 2	TERF2	244	Annotation score:
J3KSZ6	J3KSZ6_HUMAN	Telomeric repeat-binding factor 2 Telomeric repeat-binding factor 2	TERF2	144	Annotation score:
H3BTA7	H3BTA7_HUMAN	Telomeric repeat-binding factor 2 Telomeric repeat-binding factor 2	TERF2	206	Annotation score:
J3KSJ9	J3KSJ9_HUMAN	Telomeric repeat-binding factor 2 Telomeric repeat-binding factor 2	TERF2	99	Annotation score:
V9GYM1	V9GYM1_HUMAN	Telomeric repeat-binding factor 2 Telomeric repeat-binding factor 2	TERF2	86	Annotation score:
H3BR37	H3BR37_HUMAN	Telomeric repeat-binding factor 2 Telomeric repeat-binding factor 2	TERF2	60	Annotation score:
J3KTN8	J3KTN8_HUMAN	Telomeric repeat-binding factor 2 Telomeric repeat-binding factor 2	TERF2	49	Annotation score:

Sequence cautionⁱ

The sequence AAB81135 differs from that shown. Contaminating sequence. The N-terminus may be contaminated with vector sequence.Curated

The sequence AAB81135 differs from that shown. Reason: Frameshift at position 36.Curated

The sequence AAH24890 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050196	455	S → G. Corresponds to variant dbSNP:rs35874485Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003304	281 – 293	MAKKA…ESAAS → VRLGPSPITMVCP in isoform 2. 1 PublicationAdd BLAST		13
Alternative sequenceⁱVSP_003305	294 – 542	Missing in isoform 2. 1 PublicationAdd BLAST		249

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC026464 Genomic DNA No translation available. BC024890 mRNA Translation: AAH24890.1 Different initiation. AF002999 mRNA Translation: AAB81135.1 Sequence problems. U95970 mRNA Translation: AAD00821.1 X93512 mRNA Translation: CAA63769.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10879.2 [Q15554-3]
PIRⁱ	S67923
NCBI Reference Sequences More...RefSeqⁱ	NP_005643.2, NM_005652.4 [Q15554-3]
UniGeneⁱ	Hs.63335

Genome annotation databases

Ensemblⁱ	ENST00000254942; ENSP00000254942; ENSG00000132604 [Q15554-3] ENST00000567296; ENSP00000454955; ENSG00000132604 [Q15554-4]
GeneIDⁱ	7014
KEGGⁱ	hsa:7014
UCSC genome browser More...UCSCⁱ	uc002exd.5 human [Q15554-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15554	telomeric repeat-binding factor 2 isoform X1		TURTR		582	UniRef90_Q15554
Telomeric repeat binding factor 2		BOVIN		544
TERF2 isoform 2		PANTR		542
telomeric repeat-binding factor 2		LEPWE		542
TERF2 isoform 1		PONAB		542
+102
Q15554-4	TERF2 isoform 11		PONAB		293	UniRef90_Q15554-4
TERF2 isoform 3		PANTR		293
UPI0002688708		RAT		294
UPI000002B5E5		RAT		251
UPI0002687EF6		RAT		293
+2

Protein	Similar proteins		Species	Score	Length	Source
Q15554	Telomeric repeat-binding factor 2		MOUSE		541	UniRef50_Q15554
telomeric repeat-binding factor 2 isoform X1		TURTR		582
Telomeric repeat binding factor 2		BOVIN		544
Uncharacterized protein		PIG		542
telomeric repeat-binding factor 2		LEPWE		542
+232
Q15554-4	TERF2 isoform 11		PONAB		293	UniRef50_Q15554-4
TERF2 isoform 3		PANTR		293
UPI0002688708		RAT		294
UPI000002B5E5		RAT		251
UPI0002687EF6		RAT		293
+2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC026464 Genomic DNA No translation available. BC024890 mRNA Translation: AAH24890.1 Different initiation. AF002999 mRNA Translation: AAB81135.1 Sequence problems. U95970 mRNA Translation: AAD00821.1 X93512 mRNA Translation: CAA63769.1
CCDSⁱ	CCDS10879.2 [Q15554-3]
PIRⁱ	S67923
RefSeqⁱ	NP_005643.2, NM_005652.4 [Q15554-3]
UniGeneⁱ	Hs.63335

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1H6P	X-ray	2.20	A/B	85-287	[»]
	1VF9	NMR	-	A	480-542	[»]
	1VFC	NMR	-	A	480-542	[»]
	1W0U	X-ray	1.80	A/B	488-542	[»]
	1XG1	NMR	-	A	480-542	[»]
	3BU8	X-ray	2.15	A/B	84-318	[»]
	3BUA	X-ray	2.50	A/B/C/D	84-287	[»]
	3K6G	X-ray	1.95	D/E/F	317-358	[»]
	3SJM	X-ray	1.35	A/B	483-542	[»]
	4M7C	X-ray	2.05	A/B	87-286	[»]
	4RQI	X-ray	2.44	A/B/C/D	85-287	[»]
	5WQD	X-ray	3.00	A/B/C/D/E/F/G	84-287	[»]
	5XYF	X-ray	2.20	C	392-408	[»]
ProteinModelPortalⁱ	Q15554
SMRⁱ	Q15554
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112873, 270 interactors
ComplexPortalⁱ	CPX-152 Shelterin complex CPX-484 SLX4-TERF2 complex
CORUMⁱ	Q15554
DIPⁱ	DIP-34052N
ELMⁱ	Q15554
IntActⁱ	Q15554, 78 interactors
MINTⁱ	Q15554
STRINGⁱ	9606.ENSP00000254942

PTM databases

iPTMnetⁱ	Q15554
PhosphoSitePlusⁱ	Q15554

Polymorphism and mutation databases

DMDMⁱ	21542277

DMDMⁱ

21542277

Proteomic databases

EPDⁱ	Q15554
PaxDbⁱ	Q15554
PeptideAtlasⁱ	Q15554
PRIDEⁱ	Q15554
ProteomicsDBⁱ	60629

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000254942; ENSP00000254942; ENSG00000132604 [Q15554-3] ENST00000567296; ENSP00000454955; ENSG00000132604 [Q15554-4]
GeneIDⁱ	7014
KEGGⁱ	hsa:7014
UCSCⁱ	uc002exd.5 human [Q15554-3]

Organism-specific databases

CTDⁱ	7014
DisGeNETⁱ	7014
EuPathDBⁱ	HostDB:ENSG00000132604.10
GeneCardsⁱ	TERF2
HGNCⁱ	HGNC:11729 TERF2
HPAⁱ	CAB010451 HPA001907 HPA002735
MIMⁱ	602027 gene
neXtProtⁱ	NX_Q15554
OpenTargetsⁱ	ENSG00000132604
PharmGKBⁱ	PA36446
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJXM Eukaryota ENOG4111KJ3 LUCA
GeneTreeⁱ	ENSGT00530000063796
HOGENOMⁱ	HOG000154547
HOVERGENⁱ	HBG108560
InParanoidⁱ	Q15554
KOⁱ	K11111
OMAⁱ	NPKVPKG
OrthoDBⁱ	EOG091G04CC
TreeFamⁱ	TF333209

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1221632 Meiotic synapsis R-HSA-171306 Packaging Of Telomere Ends R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence

Reactomeⁱ

R-HSA-1221632 Meiotic synapsis
R-HSA-171306 Packaging Of Telomere Ends
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence

Miscellaneous databases

ChiTaRSⁱ	TERF2 human
EvolutionaryTraceⁱ	Q15554
GeneWikiⁱ	TERF2
GenomeRNAiⁱ	7014
Protein Ontology More...PROⁱ	PR:Q15554
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000132604 Expressed in 231 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_TERF2
ExpressionAtlasⁱ	Q15554 baseline and differential
Genevisibleⁱ	Q15554 HS

Family and domain databases

CDDⁱ	cd11654 TRF2_RBM, 1 hit
Gene3Dⁱ	1.25.40.210, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017930 Myb_dom IPR001005 SANT/Myb IPR013867 Telomere_rpt-bd_fac_dimer_dom IPR036507 Telomere_rpt-bd_fac_dimer_sf IPR017357 TERF1/2 IPR030657 TERF2 IPR031902 TERF2_RBM
PANTHERⁱ	PTHR21717:SF13 PTHR21717:SF13, 1 hit
Pfamⁱ	View protein in Pfam PF00249 Myb_DNA-binding, 1 hit PF16772 TERF2_RBM, 1 hit PF08558 TRF, 1 hit
PIRSFⁱ	PIRSF038016 Telomere_bd-1_Pin2, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD014243 Telomere_repeat-bd_fac_dimer, 1 hit
SMARTⁱ	View protein in SMART SM00717 SANT, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF63600 SSF63600, 1 hit
PROSITEⁱ	View protein in PROSITE PS51294 HTH_MYB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TERF2_HUMAN
Accessionⁱ	Q15554Primary (citable) accession number: Q15554
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
	Last sequence update:	April 16, 2014
	Last modified:	November 7, 2018
	This is version 195 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q15554 (TERF2_HUMAN)

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Telomeric repeat-binding factor 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ