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Protein

Protein SSXT

Gene

SS18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).2 Publications

GO - Molecular functioni

  • nuclear receptor transcription coactivator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ15532

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SSXT
Alternative name(s):
Protein SYT
Synovial sarcoma translocated to X chromosome protein
Gene namesi
Name:SS18
Synonyms:SSXT, SYT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000141380.13
HGNCiHGNC:11340 SS18
MIMi600192 gene
neXtProtiNX_Q15532

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei366 – 367Breakpoint for translocation to form the SSXT-SSX1 fusion protein (rare)1 Publication2
Sitei410 – 411Breakpoint for translocation to form the SSXT-SSX1 or SSXT-SSX2 fusion proteins1 Publication2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi6760
MalaCardsiSS18
OpenTargetsiENSG00000141380
Orphaneti3273 Synovial sarcoma
PharmGKBiPA36164

Polymorphism and mutation databases

BioMutaiSS18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001818232 – 418Protein SSXTAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15532
MaxQBiQ15532
PaxDbiQ15532
PeptideAtlasiQ15532
PRIDEiQ15532
ProteomicsDBi60621
60622 [Q15532-2]

PTM databases

iPTMnetiQ15532
PhosphoSitePlusiQ15532

Expressioni

Tissue specificityi

Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.

Gene expression databases

BgeeiENSG00000141380 Expressed in 225 organ(s), highest expression level in kidney
CleanExiHS_SS18
ExpressionAtlasiQ15532 baseline and differential
GenevisibleiQ15532 HS

Organism-specific databases

HPAiHPA055741
HPA059539

Interactioni

Subunit structurei

Interacts with MLLT10. Isoform 1 interacts with RBM14 isoform 1. Isoform 2 interacts with RBM14 isoform 1. Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATF2P153362EBI-2560599,EBI-1170906

Protein-protein interaction databases

BioGridi112638, 48 interactors
IntActiQ15532, 22 interactors
STRINGi9606.ENSP00000414516

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati344 – 3561Add BLAST13
Repeati357 – 3692Add BLAST13

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 186Transcriptional activationAdd BLAST185
Regioni344 – 3692 X 13 AA imperfect tandem repeatsAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 53SH2-bindingSequence analysis4
Motifi374 – 377SH2-bindingSequence analysis4
Motifi392 – 401SH3-bindingSequence analysis10
Motifi413 – 416SH2-bindingSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi95 – 99Poly-Pro5
Compositional biasi175 – 418Gln-richAdd BLAST244

Sequence similaritiesi

Belongs to the SS18 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3227 Eukaryota
ENOG41128HA LUCA
GeneTreeiENSGT00500000044808
HOVERGENiHBG003892
InParanoidiQ15532
KOiK15623
OMAiYNMPQAG
OrthoDBiEOG091G0O10
PhylomeDBiQ15532
TreeFamiTF330999

Family and domain databases

InterProiView protein in InterPro
IPR007726 SS18_fam
PfamiView protein in Pfam
PF05030 SSXT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15532-1) [UniParc]FASTAAdd to basket
Also known as: SYTins, SYT-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVAFAAPRQ RGKGEITPAA IQKMLDDNNH LIQCIMDSQN KGKTSECSQY
60 70 80 90 100
QQMLHTNLVY LATIADSNQN MQSLLPAPPT QNMPMGPGGM NQSGPPPPPR
110 120 130 140 150
SHNMPSDGMV GGGPPAPHMQ NQMNGQMPGP NHMPMQGPGP NQLNMTNSSM
160 170 180 190 200
NMPSSSHGSM GGYNHSVPSS QSMPVQNQMT MSQGQPMGNY GPRPNMSMQP
210 220 230 240 250
NQGPMMHQQP PSQQYNMPQG GGQHYQGQQP PMGMMGQVNQ GNHMMGQRQI
260 270 280 290 300
PPYRPPQQGP PQQYSGQEDY YGDQYSHGGQ GPPEGMNQQY YPDGHNDYGY
310 320 330 340 350
QQPSYPEQGY DRPYEDSSQH YYEGGNSQYG QQQDAYQGPP PQQGYPPQQQ
360 370 380 390 400
QYPGQQGYPG QQQGYGPSQG GPGPQYPNYP QGQGQQYGGY RPTQPGPPQP
410
PQQRPYGYDQ GQYGNYQQ
Length:418
Mass (Da):45,929
Last modified:January 31, 2002 - v3
Checksum:i7E089D557538252F
GO
Isoform 2 (identifier: Q15532-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-325: Missing.

Show »
Length:387
Mass (Da):42,216
Checksum:iA1D64C2C588C532A
GO

Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DLD3B4DLD3_HUMAN
Protein SSXT
SS18
395Annotation score:
J3KT74J3KT74_HUMAN
Protein SSXT
SS18
84Annotation score:
J3QQW2J3QQW2_HUMAN
Protein SSXT
SS18
94Annotation score:
J3QS72J3QS72_HUMAN
Protein SSXT
SS18
60Annotation score:
X6R3J2X6R3J2_HUMAN
Protein SSXT
SS18
61Annotation score:
J3QLJ7J3QLJ7_HUMAN
Protein SSXT
SS18
70Annotation score:
J3QQX5J3QQX5_HUMAN
Protein SSXT
SS18
130Annotation score:
J3KT22J3KT22_HUMAN
Protein SSXT
SS18
152Annotation score:
J3QSB3J3QSB3_HUMAN
Protein SSXT
SS18
35Annotation score:
J3QQM2J3QQM2_HUMAN
Protein SSXT
SS18
68Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAK21314 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA55792 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006258295 – 325Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79201 mRNA Translation: CAA55792.1 Different initiation.
X79200 mRNA No translation available.
AF343880 mRNA Translation: AAK21314.1 Different initiation.
EF445031 Genomic DNA Translation: ACA06073.1
CH471088 Genomic DNA Translation: EAX01210.1
BC096223 mRNA Translation: AAH96223.1
S79894 mRNA Translation: AAB35674.1 Different termination.
CCDSiCCDS32807.1 [Q15532-1]
CCDS54183.1 [Q15532-2]
PIRiS46269
RefSeqiNP_001007560.1, NM_001007559.2 [Q15532-1]
NP_001295130.1, NM_001308201.1
NP_005628.2, NM_005637.3 [Q15532-2]
UniGeneiHs.129261

Genome annotation databases

EnsembliENST00000269137; ENSP00000269137; ENSG00000141380 [Q15532-2]
ENST00000415083; ENSP00000414516; ENSG00000141380 [Q15532-1]
GeneIDi6760
KEGGihsa:6760
UCSCiuc002kvm.4 human [Q15532-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79201 mRNA Translation: CAA55792.1 Different initiation.
X79200 mRNA No translation available.
AF343880 mRNA Translation: AAK21314.1 Different initiation.
EF445031 Genomic DNA Translation: ACA06073.1
CH471088 Genomic DNA Translation: EAX01210.1
BC096223 mRNA Translation: AAH96223.1
S79894 mRNA Translation: AAB35674.1 Different termination.
CCDSiCCDS32807.1 [Q15532-1]
CCDS54183.1 [Q15532-2]
PIRiS46269
RefSeqiNP_001007560.1, NM_001007559.2 [Q15532-1]
NP_001295130.1, NM_001308201.1
NP_005628.2, NM_005637.3 [Q15532-2]
UniGeneiHs.129261

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112638, 48 interactors
IntActiQ15532, 22 interactors
STRINGi9606.ENSP00000414516

PTM databases

iPTMnetiQ15532
PhosphoSitePlusiQ15532

Polymorphism and mutation databases

BioMutaiSS18

Proteomic databases

EPDiQ15532
MaxQBiQ15532
PaxDbiQ15532
PeptideAtlasiQ15532
PRIDEiQ15532
ProteomicsDBi60621
60622 [Q15532-2]

Protocols and materials databases

DNASUi6760
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269137; ENSP00000269137; ENSG00000141380 [Q15532-2]
ENST00000415083; ENSP00000414516; ENSG00000141380 [Q15532-1]
GeneIDi6760
KEGGihsa:6760
UCSCiuc002kvm.4 human [Q15532-1]

Organism-specific databases

CTDi6760
DisGeNETi6760
EuPathDBiHostDB:ENSG00000141380.13
GeneCardsiSS18
HGNCiHGNC:11340 SS18
HPAiHPA055741
HPA059539
MalaCardsiSS18
MIMi600192 gene
neXtProtiNX_Q15532
OpenTargetsiENSG00000141380
Orphaneti3273 Synovial sarcoma
PharmGKBiPA36164
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3227 Eukaryota
ENOG41128HA LUCA
GeneTreeiENSGT00500000044808
HOVERGENiHBG003892
InParanoidiQ15532
KOiK15623
OMAiYNMPQAG
OrthoDBiEOG091G0O10
PhylomeDBiQ15532
TreeFamiTF330999

Enzyme and pathway databases

SIGNORiQ15532

Miscellaneous databases

ChiTaRSiSS18 human
GeneWikiiSS18
GenomeRNAii6760
PROiPR:Q15532
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141380 Expressed in 225 organ(s), highest expression level in kidney
CleanExiHS_SS18
ExpressionAtlasiQ15532 baseline and differential
GenevisibleiQ15532 HS

Family and domain databases

InterProiView protein in InterPro
IPR007726 SS18_fam
PfamiView protein in Pfam
PF05030 SSXT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSSXT_HUMAN
AccessioniPrimary (citable) accession number: Q15532
Secondary accession number(s): B0YJ95
, Q16404, Q4VAX1, Q9BXC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 31, 2002
Last modified: November 7, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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