Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q15528 (MED22_HUMAN)

Protein

Mediator of RNA polymerase II transcription subunit 22

Gene

MED22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 22
Alternative name(s):
Mediator complex subunit 22
Surfeit locus protein 5
Short name:
Surf-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED22
Synonyms:SURF5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000148297.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:11477 MED22

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		185641 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15528

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000148297

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162395486

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MED22

Domain mapping of disease mutations (DMDM)

More...DMDMi		6175074

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001788381 – 200Mediator of RNA polymerase II transcription subunit 22Add BLAST200

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15528

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15528

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15528

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15528

PeptideAtlas

More...PeptideAtlasi		Q15528

PRoteomics IDEntifications database

More...PRIDEi		Q15528

ProteomicsDB human proteome resource

More...ProteomicsDBi		60619
60620 [Q15528-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q15528-2 [Q15528-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15528

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15528

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148297 Expressed in 180 organ(s), highest expression level in heart left ventricle

CleanEx database of gene expression profiles

More...CleanExi		HS_MED22

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15528 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15528 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA020391
HPA063694

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112704, 52 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3227 Core mediator complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15528

Protein interaction database and analysis system

More...IntActi		Q15528, 24 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000342343

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q15528

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15528

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili93 – 122Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi136 – 140Poly-Ser5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 22 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3304 Eukaryota
ENOG410XS6U LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004339

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000006377

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG058487

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15528

KEGG Orthology (KO)

More...KOi		K15139

Identification of Orthologs from Complete Genome Data

More...OMAi		KQAECDQ

Database of Orthologous Groups

More...OrthoDBi		1573728at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15528

TreeFam database of animal gene trees

More...TreeFami		TF323390

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.1600, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009332 Med22
IPR038427 MED22_sf

The PANTHER Classification System

More...PANTHERi		PTHR12434 PTHR12434, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06179 Med22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Surf5B (identifier: Q15528-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQQRALPQS KETLLQSYNK RLKDDIKSIM DNFTEIIKTA KIEDETQVSR 
        60         70         80         90        100
ATQGEQDNYE MHVRAANIVR AGESLMKLVS DLKQFLILND FPSVNEAIDQ 
       110        120        130        140        150
RNQQLRTLQE ECDRKLITLR DEISIDLYEL EEEYYSSSSS LCEANDLPLC 
       160        170        180        190        200
EAYGRLDLDT DSADGLSAPL LASPEPSAGP LQVAAPAHSH AGGPGPTEHA
Length:200
Mass (Da):22,221
Last modified:July 15, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i113BBF7C35B03F7B
GO
Isoform Surf5A (identifier: Q15528-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-200: SSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA → RYK

Show »
Length:140
Mass (Da):16,480
Checksum:i8D720D36F1171AE1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T8T7Q5T8T7_HUMAN
Mediator complex subunit 22
MED22 RP11-244N20.9-003
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T8T8Q5T8T8_HUMAN
Mediator complex subunit 22
MED22 RP11-244N20.9-005
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGW7E9PGW7_HUMAN
Mediator of RNA polymerase II trans...
MED22
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EN96E7EN96_HUMAN
Mediator of RNA polymerase II trans...
MED22
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006309138 – 200SSSLC…PTEHA → RYK in isoform Surf5A. 3 PublicationsAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X85178 mRNA Translation: CAA59462.1
AJ224639 Genomic DNA Translation: CAA12052.1
AJ224639 Genomic DNA Translation: CAA12053.1
AJ224358 mRNA Translation: CAA11915.1
AJ224359 mRNA Translation: CAA11916.1
AK124518 mRNA Translation: BAG54045.1
AK126069 mRNA Translation: BAG54286.1
AL158826 Genomic DNA Translation: CAI12827.1
CH471090 Genomic DNA Translation: EAW88056.1
CH471090 Genomic DNA Translation: EAW88060.1
BC024225 mRNA Translation: AAH24225.1
BC040111 mRNA Translation: AAH40111.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6963.1 [Q15528-1]
CCDS6964.1 [Q15528-2]

NCBI Reference Sequences

More...RefSeqi		NP_598395.1, NM_133640.4 [Q15528-1]
NP_852468.1, NM_181491.2 [Q15528-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.78354

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343730; ENSP00000342343; ENSG00000148297 [Q15528-1]
ENST00000610672; ENSP00000482438; ENSG00000148297 [Q15528-1]
ENST00000610888; ENSP00000478773; ENSG00000148297 [Q15528-2]
ENST00000614493; ENSP00000481493; ENSG00000148297 [Q15528-2]
ENST00000626118; ENSP00000485715; ENSG00000281022 [Q15528-2]
ENST00000629522; ENSP00000485880; ENSG00000281022 [Q15528-1]
ENST00000629975; ENSP00000486722; ENSG00000281022 [Q15528-2]
ENST00000631196; ENSP00000487580; ENSG00000281022 [Q15528-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6837

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6837

UCSC genome browser

More...UCSCi		uc004cdc.5 human [Q15528-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85178 mRNA Translation: CAA59462.1
AJ224639 Genomic DNA Translation: CAA12052.1
AJ224639 Genomic DNA Translation: CAA12053.1
AJ224358 mRNA Translation: CAA11915.1
AJ224359 mRNA Translation: CAA11916.1
AK124518 mRNA Translation: BAG54045.1
AK126069 mRNA Translation: BAG54286.1
AL158826 Genomic DNA Translation: CAI12827.1
CH471090 Genomic DNA Translation: EAW88056.1
CH471090 Genomic DNA Translation: EAW88060.1
BC024225 mRNA Translation: AAH24225.1
BC040111 mRNA Translation: AAH40111.1
CCDSiCCDS6963.1 [Q15528-1]
CCDS6964.1 [Q15528-2]
RefSeqiNP_598395.1, NM_133640.4 [Q15528-1]
NP_852468.1, NM_181491.2 [Q15528-2]
UniGeneiHs.78354

3D structure databases

ProteinModelPortaliQ15528
SMRiQ15528
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112704, 52 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ15528
IntActiQ15528, 24 interactors
STRINGi9606.ENSP00000342343

PTM databases

iPTMnetiQ15528
PhosphoSitePlusiQ15528

Polymorphism and mutation databases

BioMutaiMED22
DMDMi6175074

Proteomic databases

EPDiQ15528
jPOSTiQ15528
MaxQBiQ15528
PaxDbiQ15528
PeptideAtlasiQ15528
PRIDEiQ15528
ProteomicsDBi60619
60620 [Q15528-2]
TopDownProteomicsiQ15528-2 [Q15528-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6837
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343730; ENSP00000342343; ENSG00000148297 [Q15528-1]
ENST00000610672; ENSP00000482438; ENSG00000148297 [Q15528-1]
ENST00000610888; ENSP00000478773; ENSG00000148297 [Q15528-2]
ENST00000614493; ENSP00000481493; ENSG00000148297 [Q15528-2]
ENST00000626118; ENSP00000485715; ENSG00000281022 [Q15528-2]
ENST00000629522; ENSP00000485880; ENSG00000281022 [Q15528-1]
ENST00000629975; ENSP00000486722; ENSG00000281022 [Q15528-2]
ENST00000631196; ENSP00000487580; ENSG00000281022 [Q15528-1]
GeneIDi6837
KEGGihsa:6837
UCSCiuc004cdc.5 human [Q15528-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6837
EuPathDBiHostDB:ENSG00000148297.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		MED22
HGNCiHGNC:11477 MED22
HPAiHPA020391
HPA063694
MIMi185641 gene
neXtProtiNX_Q15528
OpenTargetsiENSG00000148297
PharmGKBiPA162395486

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3304 Eukaryota
ENOG410XS6U LUCA
GeneTreeiENSGT00390000004339
HOGENOMiHOG000006377
HOVERGENiHBG058487
InParanoidiQ15528
KOiK15139
OMAiKQAECDQ
OrthoDBi1573728at2759
PhylomeDBiQ15528
TreeFamiTF323390

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MED22

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6837

Protein Ontology

More...PROi		PR:Q15528

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148297 Expressed in 180 organ(s), highest expression level in heart left ventricle
CleanExiHS_MED22
ExpressionAtlasiQ15528 baseline and differential
GenevisibleiQ15528 HS

Family and domain databases

Gene3Di1.20.58.1600, 1 hit
InterProiView protein in InterPro
IPR009332 Med22
IPR038427 MED22_sf
PANTHERiPTHR12434 PTHR12434, 1 hit
PfamiView protein in Pfam
PF06179 Med22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED22_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15528
Secondary accession number(s): B3KW83
, B3KWX4, O76072, Q5T8U0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: January 16, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again