MED22

Functionⁱ

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functionⁱ

transcription coregulator activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription by RNA polymerase II Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mediator of RNA polymerase II transcription subunit 22 Alternative name(s): Mediator complex subunit 22 Surfeit locus protein 5 Short name: Surf-5
Gene namesⁱ	Name:MED22 Synonyms:SURF5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148297.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11477 MED22
MIMⁱ	185641 gene
neXtProtⁱ	NX_Q15528

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000148297
PharmGKBⁱ	PA162395486

Polymorphism and mutation databases

DMDMⁱ	6175074

DMDMⁱ

6175074

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000178838	1 – 200	Mediator of RNA polymerase II transcription subunit 22Add BLAST		200

Proteomic databases

EPDⁱ	Q15528
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15528
PaxDbⁱ	Q15528
PeptideAtlas More...PeptideAtlasⁱ	Q15528
PRIDEⁱ	Q15528
ProteomicsDBⁱ	60619 60620 [Q15528-2]
TopDownProteomicsⁱ	Q15528-2 [Q15528-2]

PTM databases

iPTMnetⁱ	Q15528
PhosphoSitePlusⁱ	Q15528

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148297 Expressed in 180 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_MED22
ExpressionAtlasⁱ	Q15528 baseline and differential
Genevisibleⁱ	Q15528 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA020391 HPA063694

HPAⁱ

HPA020391
HPA063694

Interactionⁱ

Subunit structureⁱ

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MED11	Q9P086	3	EBI-394687,EBI-394704
Med11	Q9D8C6	2	EBI-394687,EBI-6260909	From Mus musculus.
MED17	Q9NVC6	3	EBI-394687,EBI-394562
MED18	Q9BUE0	2	EBI-394687,EBI-394640
MED27	Q6P2C8	3	EBI-394687,EBI-394603
MED28	Q9H204	2	EBI-394687,EBI-514199
MED29	Q9NX70	4	EBI-394687,EBI-394656
Med30	Q9CQI9	6	EBI-394687,EBI-309220	From Mus musculus.
Med8	Q9D7W5	2	EBI-394687,EBI-7990252	From Mus musculus.

Protein-protein interaction databases

BioGridⁱ	112704, 52 interactors
ComplexPortalⁱ	CPX-3227 Core mediator complex
CORUMⁱ	Q15528
IntActⁱ	Q15528, 24 interactors
STRINGⁱ	9606.ENSP00000342343

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15528
SMRⁱ	Q15528
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	93 – 122	Sequence analysisAdd BLAST		30

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	136 – 140	Poly-Ser		5

Sequence similaritiesⁱ

Belongs to the Mediator complex subunit 22 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3304 Eukaryota ENOG410XS6U LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004339
HOGENOMⁱ	HOG000006377
HOVERGENⁱ	HBG058487
InParanoidⁱ	Q15528
KEGG Orthology (KO) More...KOⁱ	K15139
OMAⁱ	KQAECDQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0SIM
PhylomeDBⁱ	Q15528
TreeFamⁱ	TF323390

Family and domain databases

Gene3Dⁱ	1.20.58.1600, 1 hit
InterProⁱ	View protein in InterPro IPR009332 Med22 IPR038427 MED22_sf
PANTHERⁱ	PTHR12434 PTHR12434, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06179 Med22, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform Surf5B (identifier: Q15528-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQQRALPQS KETLLQSYNK RLKDDIKSIM DNFTEIIKTA KIEDETQVSR 
        60         70         80         90        100
ATQGEQDNYE MHVRAANIVR AGESLMKLVS DLKQFLILND FPSVNEAIDQ 
       110        120        130        140        150
RNQQLRTLQE ECDRKLITLR DEISIDLYEL EEEYYSSSSS LCEANDLPLC 
       160        170        180        190        200
EAYGRLDLDT DSADGLSAPL LASPEPSAGP LQVAAPAHSH AGGPGPTEHA

Length:200

Mass (Da):22,221

Last modified:July 15, 1999 - v2

Checksum:ⁱ113BBF7C35B03F7B

GO

Isoform Surf5A (identifier: Q15528-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
138-200: SSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA → RYK

« Hide

        10         20         30         40         50
MAQQRALPQS KETLLQSYNK RLKDDIKSIM DNFTEIIKTA KIEDETQVSR 
        60         70         80         90        100
ATQGEQDNYE MHVRAANIVR AGESLMKLVS DLKQFLILND FPSVNEAIDQ 
       110        120        130        140
RNQQLRTLQE ECDRKLITLR DEISIDLYEL EEEYYSSRYK

Show »

Length:140

Mass (Da):16,480

Checksum:ⁱ8D720D36F1171AE1

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5T8T7	Q5T8T7_HUMAN	Mediator complex subunit 22 Mediator complex subunit 22 (Mediator of RNA polymerase II transcription subunit 22)	MED22 RP11-244N20.9-003	134	Annotation score:
E9PGW7	E9PGW7_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 22	MED22	111	Annotation score:
Q5T8T8	Q5T8T8_HUMAN	Mediator complex subunit 22 Mediator complex subunit 22 (Mediator of RNA polymerase II transcription subunit 22)	MED22 RP11-244N20.9-005	137	Annotation score:
E7EN96	E7EN96_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 22	MED22	135	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006309	138 – 200	SSSLC…PTEHA → RYK in isoform Surf5A. 3 PublicationsAdd BLAST		63

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X85178 mRNA Translation: CAA59462.1 AJ224639 Genomic DNA Translation: CAA12052.1 AJ224639 Genomic DNA Translation: CAA12053.1 AJ224358 mRNA Translation: CAA11915.1 AJ224359 mRNA Translation: CAA11916.1 AK124518 mRNA Translation: BAG54045.1 AK126069 mRNA Translation: BAG54286.1 AL158826 Genomic DNA Translation: CAI12827.1 CH471090 Genomic DNA Translation: EAW88056.1 CH471090 Genomic DNA Translation: EAW88060.1 BC024225 mRNA Translation: AAH24225.1 BC040111 mRNA Translation: AAH40111.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6963.1 [Q15528-1] CCDS6964.1 [Q15528-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_598395.1, NM_133640.4 [Q15528-1] NP_852468.1, NM_181491.2 [Q15528-2]
UniGeneⁱ	Hs.78354

Genome annotation databases

Ensemblⁱ	ENST00000343730; ENSP00000342343; ENSG00000148297 [Q15528-1] ENST00000610672; ENSP00000482438; ENSG00000148297 [Q15528-1] ENST00000610888; ENSP00000478773; ENSG00000148297 [Q15528-2] ENST00000614493; ENSP00000481493; ENSG00000148297 [Q15528-2] ENST00000626118; ENSP00000485715; ENSG00000281022 [Q15528-2] ENST00000629522; ENSP00000485880; ENSG00000281022 [Q15528-1] ENST00000629975; ENSP00000486722; ENSG00000281022 [Q15528-2] ENST00000631196; ENSP00000487580; ENSG00000281022 [Q15528-1]
GeneIDⁱ	6837
KEGGⁱ	hsa:6837
UCSC genome browser More...UCSCⁱ	uc004cdc.5 human [Q15528-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15528	Surfeit 5, isoform CRA_a		HUMAN		200	UniRef100_Q15528
Mediator complex subunit 22 (Fragment)		HUMAN		137
Mediator of RNA polymerase II transcription subunit 22 (Fragment)		HUMAN		135

Protein	Similar proteins		Species	Score	Length	Source
Q15528	Mediator of RNA polymerase II transcription subunit 22		BOVIN		201	UniRef90_Q15528
Mediator of RNA polymerase II transcription subunit 22		RAT		200
Mediator of RNA polymerase II transcription subunit 22		MOUSE		200
Surfeit 5, isoform CRA_a		HUMAN		200
Mediator of RNA polymerase II transcription subunit 22		HETGA		229
+95
Q15528-2	Mediator of RNA polymerase II transcription subunit 22-like		CROAD		140	UniRef90_Q15528-2
Uncharacterized protein		BAMTH		140
Isoform 2 of Mediator of RNA polymerase II transcription subunit 22		CHICK		140
Isoform 2 of Mediator of RNA polymerase II transcription subunit 22		BOVIN		140
Surfeit locus protein 5 (Fragment)		MUSPF		140
+29

Protein	Similar proteins		Species	Score	Length	Source
Q15528	Mediator of RNA polymerase II transcription subunit 22		BOVIN		201	UniRef50_Q15528
Mediator of RNA polymerase II transcription subunit 22		RAT		200
Mediator of RNA polymerase II transcription subunit 22		MOUSE		200
Mediator of RNA polymerase II transcription subunit 22		CHICK		203
Surfeit 5, isoform CRA_a		HUMAN		200
+206
Q15528-2	Mediator of RNA polymerase II transcription subunit 22		PTEAL		140	UniRef50_Q15528-2
Uncharacterized protein		CALSU		140
Mediator of RNA polymerase II transcription subunit 22 isoform c		MACMU		140
MED22 isoform 5		PANTR		140
Mediator of RNA polymerase II transcription subunit 22 isoform c		CALJA		140
+111

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X85178 mRNA Translation: CAA59462.1 AJ224639 Genomic DNA Translation: CAA12052.1 AJ224639 Genomic DNA Translation: CAA12053.1 AJ224358 mRNA Translation: CAA11915.1 AJ224359 mRNA Translation: CAA11916.1 AK124518 mRNA Translation: BAG54045.1 AK126069 mRNA Translation: BAG54286.1 AL158826 Genomic DNA Translation: CAI12827.1 CH471090 Genomic DNA Translation: EAW88056.1 CH471090 Genomic DNA Translation: EAW88060.1 BC024225 mRNA Translation: AAH24225.1 BC040111 mRNA Translation: AAH40111.1
CCDSⁱ	CCDS6963.1 [Q15528-1] CCDS6964.1 [Q15528-2]
RefSeqⁱ	NP_598395.1, NM_133640.4 [Q15528-1] NP_852468.1, NM_181491.2 [Q15528-2]
UniGeneⁱ	Hs.78354

3D structure databases

ProteinModelPortalⁱ	Q15528
SMRⁱ	Q15528
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112704, 52 interactors
ComplexPortalⁱ	CPX-3227 Core mediator complex
CORUMⁱ	Q15528
IntActⁱ	Q15528, 24 interactors
STRINGⁱ	9606.ENSP00000342343

PTM databases

iPTMnetⁱ	Q15528
PhosphoSitePlusⁱ	Q15528

Polymorphism and mutation databases

DMDMⁱ	6175074

DMDMⁱ

6175074

Proteomic databases

EPDⁱ	Q15528
MaxQBⁱ	Q15528
PaxDbⁱ	Q15528
PeptideAtlasⁱ	Q15528
PRIDEⁱ	Q15528
ProteomicsDBⁱ	60619 60620 [Q15528-2]
TopDownProteomicsⁱ	Q15528-2 [Q15528-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6837
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000343730; ENSP00000342343; ENSG00000148297 [Q15528-1] ENST00000610672; ENSP00000482438; ENSG00000148297 [Q15528-1] ENST00000610888; ENSP00000478773; ENSG00000148297 [Q15528-2] ENST00000614493; ENSP00000481493; ENSG00000148297 [Q15528-2] ENST00000626118; ENSP00000485715; ENSG00000281022 [Q15528-2] ENST00000629522; ENSP00000485880; ENSG00000281022 [Q15528-1] ENST00000629975; ENSP00000486722; ENSG00000281022 [Q15528-2] ENST00000631196; ENSP00000487580; ENSG00000281022 [Q15528-1]
GeneIDⁱ	6837
KEGGⁱ	hsa:6837
UCSCⁱ	uc004cdc.5 human [Q15528-1]

Organism-specific databases

CTDⁱ	6837
EuPathDBⁱ	HostDB:ENSG00000148297.15
GeneCardsⁱ	MED22
HGNCⁱ	HGNC:11477 MED22
HPAⁱ	HPA020391 HPA063694
MIMⁱ	185641 gene
neXtProtⁱ	NX_Q15528
OpenTargetsⁱ	ENSG00000148297
PharmGKBⁱ	PA162395486
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3304 Eukaryota ENOG410XS6U LUCA
GeneTreeⁱ	ENSGT00390000004339
HOGENOMⁱ	HOG000006377
HOVERGENⁱ	HBG058487
InParanoidⁱ	Q15528
KOⁱ	K15139
OMAⁱ	KQAECDQ
OrthoDBⁱ	EOG091G0SIM
PhylomeDBⁱ	Q15528
TreeFamⁱ	TF323390

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

GeneWikiⁱ	MED22
GenomeRNAiⁱ	6837
Protein Ontology More...PROⁱ	PR:Q15528
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148297 Expressed in 180 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_MED22
ExpressionAtlasⁱ	Q15528 baseline and differential
Genevisibleⁱ	Q15528 HS

Family and domain databases

Gene3Dⁱ	1.20.58.1600, 1 hit
InterProⁱ	View protein in InterPro IPR009332 Med22 IPR038427 MED22_sf
PANTHERⁱ	PTHR12434 PTHR12434, 1 hit
Pfamⁱ	View protein in Pfam PF06179 Med22, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MED22_HUMAN
Accessionⁱ	Q15528Primary (citable) accession number: Q15528 Secondary accession number(s): B3KW83 , B3KWX4, O76072, Q5T8U0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 15, 1999
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniProtKB - Q15528 (MED22_HUMAN)

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Mediator of RNA polymerase II transcription subunit 22

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ