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Entry version 137 (08 May 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Surfeit locus protein 2

Gene

SURF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Surfeit locus protein 2
Short name:
Surf-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SURF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:11475 SURF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
185630 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15527

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6835

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36260

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SURF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373505

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000723191 – 256Surfeit locus protein 2Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei190PhosphothreonineCombined sources1
Modified residuei195PhosphothreonineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15527

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15527

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15527

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15527

PeptideAtlas

More...
PeptideAtlasi
Q15527

PRoteomics IDEntifications database

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PRIDEi
Q15527

ProteomicsDB human proteome resource

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ProteomicsDBi
60618

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15527

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15527

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148291 Expressed in 162 organ(s), highest expression level in left testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15527 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA044340
HPA052213

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112702, 59 interactors

Protein interaction database and analysis system

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IntActi
Q15527, 7 interactors

Molecular INTeraction database

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MINTi
Q15527

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361032

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15527

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SURF2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK6I Eukaryota
ENOG4111NE1 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000136540

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15527

Database of Orthologous Groups

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OrthoDBi
1602731at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15527

TreeFam database of animal gene trees

More...
TreeFami
TF329107

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q15527-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK
60 70 80 90 100
KYQRLVRASP AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH
110 120 130 140 150
TQGRRYQRAL CKYEECQKQG VEYVPACLVH RRRRREDQMD GDGPRPREAF
160 170 180 190 200
WEPTSSDEGG AASDDSMTDL YPPELFTRKD LGSTEDGDGT DDFLTDKEDE
210 220 230 240 250
KAKPPREKAT DESRRETTVY RGLVQKRGKK QLGSLKKKFK SHHRKPKSFS

SCKQPG
Length:256
Mass (Da):29,648
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CA1BDEB73CB5127
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24A → T in CAA84477 (PubMed:7702754).Curated1
Sequence conflicti37P → T in CAA84477 (PubMed:7702754).Curated1
Sequence conflicti142 – 143DG → EA in CAA84477 (PubMed:7702754).Curated2
Sequence conflicti160G → A in CAA84477 (PubMed:7702754).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014785213S → G2 PublicationsCorresponds to variant dbSNP:rs12763Ensembl.1
Natural variantiVAR_057001221R → Q1 PublicationCorresponds to variant dbSNP:rs7863933Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z35094 mRNA Translation: CAA84477.1
CR456753 mRNA Translation: CAG33034.1
AL158826 Genomic DNA Translation: CAI12838.1
BC014411 mRNA Translation: AAH14411.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6967.1

Protein sequence database of the Protein Information Resource

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PIRi
S57747

NCBI Reference Sequences

More...
RefSeqi
NP_001265857.1, NM_001278928.1
NP_059973.4, NM_017503.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371964; ENSP00000361032; ENSG00000148291

Database of genes from NCBI RefSeq genomes

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GeneIDi
6835

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6835

UCSC genome browser

More...
UCSCi
uc004cdi.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35094 mRNA Translation: CAA84477.1
CR456753 mRNA Translation: CAG33034.1
AL158826 Genomic DNA Translation: CAI12838.1
BC014411 mRNA Translation: AAH14411.1
CCDSiCCDS6967.1
PIRiS57747
RefSeqiNP_001265857.1, NM_001278928.1
NP_059973.4, NM_017503.4

3D structure databases

SMRiQ15527
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112702, 59 interactors
IntActiQ15527, 7 interactors
MINTiQ15527
STRINGi9606.ENSP00000361032

PTM databases

iPTMnetiQ15527
PhosphoSitePlusiQ15527

Polymorphism and mutation databases

BioMutaiSURF2
DMDMi317373505

Proteomic databases

EPDiQ15527
jPOSTiQ15527
MaxQBiQ15527
PaxDbiQ15527
PeptideAtlasiQ15527
PRIDEiQ15527
ProteomicsDBi60618

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6835
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371964; ENSP00000361032; ENSG00000148291
GeneIDi6835
KEGGihsa:6835
UCSCiuc004cdi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6835
DisGeNETi6835

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SURF2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008504
HGNCiHGNC:11475 SURF2
HPAiHPA044340
HPA052213
MIMi185630 gene
neXtProtiNX_Q15527
PharmGKBiPA36260

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK6I Eukaryota
ENOG4111NE1 LUCA
HOGENOMiHOG000136540
InParanoidiQ15527
OrthoDBi1602731at2759
PhylomeDBiQ15527
TreeFamiTF329107

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SURF2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6835

Protein Ontology

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PROi
PR:Q15527

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148291 Expressed in 162 organ(s), highest expression level in left testis
GenevisibleiQ15527 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSURF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15527
Secondary accession number(s): Q6IBP9, Q96CD1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2011
Last modified: May 8, 2019
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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