SURF1

Functionⁱ

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.1 Publication2 Publications

GO - Molecular functionⁱ

cytochrome-c oxidase activity
Source: ProtInc
Traceable author statementⁱ
- 9843204

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aerobic respiration
Source: ProtInc
Traceable author statementⁱ
- 9843204
ATP biosynthetic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20888800
mitochondrial respiratory chain complex IV assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24027061
oxidation-reduction process
Source: ProtInc
Traceable author statementⁱ
- 9843204
oxidative phosphorylation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20888800
respiratory chain complex IV assembly
Source: ProtInc
Traceable author statementⁱ
- 9843204

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-611105 Respiratory electron transport
SIGNORⁱ	Q15526

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Surfeit locus protein 1
Gene namesⁱ	Name:SURF1 Synonyms:SURF-1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148290.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11474 SURF1
MIMⁱ	185620 gene
neXtProtⁱ	NX_Q15526

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	61 – 79	HelicalSequence analysisAdd BLAST		19
Transmembraneⁱ	274 – 290	HelicalSequence analysisAdd BLAST		17

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Leigh syndrome (LS)7 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_068649	90	L → P in LS. 1 PublicationCorresponds to variant dbSNP:rs782024654EnsemblClinVar.	1
Natural variantⁱVAR_007450	124	G → E in LS. 1 PublicationCorresponds to variant dbSNP:rs28933402EnsemblClinVar.	1
Natural variantⁱVAR_015258	124	G → R in LS. Corresponds to variant dbSNP:rs782033035Ensembl.	1
Natural variantⁱVAR_068650	177	V → G in LS. 1 Publication	1
Natural variantⁱVAR_068651	205	G → E in LS. 1 Publication	1
Natural variantⁱVAR_068682	227	W → R in LS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398122806EnsemblClinVar.	1
Natural variantⁱVAR_068652	235	M → T in LS. 1 Publication	1
Natural variantⁱVAR_007452	246	I → T in LS. 1 Publication	1
Natural variantⁱVAR_068653	248	A → D in LS. 1 Publication	1
Natural variantⁱVAR_068654	257	G → R in LS. 1 Publication	1
Natural variantⁱVAR_015259	274	Y → D in LS. 1 PublicationCorresponds to variant dbSNP:rs121918658EnsemblClinVar.	1

Charcot-Marie-Tooth disease 4K (CMT4K)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive, demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. CMT4K patients manifest upper and lower limbs involvement. Some affected individuals have nystagmus and late-onset cerebellar ataxia.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_076315	192	R → W in CMT4K; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs782190413EnsemblClinVar.		1

Keywords - Diseaseⁱ

Charcot-Marie-Tooth disease, Disease mutation, Leigh syndrome, Neurodegeneration, Neuropathy, Primary mitochondrial disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6834
MalaCards human disease database More...MalaCardsⁱ	SURF1
MIMⁱ	256000 phenotype 616684 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000148290
Orphanetⁱ	1561 Fatal infantile cytochrome C oxidase deficiency 70474 Leigh syndrome with cardiomyopathy 255241 Leigh syndrome with leukodystrophy 391351 SURF1-related Charcot-Marie-Tooth disease type 4
PharmGKBⁱ	PA36259

Polymorphism and mutation databases

DMDMⁱ	2498973

DMDMⁱ

2498973

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215652	1 – 300	Surfeit locus protein 1Add BLAST		300

Proteomic databases

EPDⁱ	Q15526
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15526
PaxDbⁱ	Q15526
PeptideAtlas More...PeptideAtlasⁱ	Q15526
PRIDEⁱ	Q15526
ProteomicsDBⁱ	60616 60617 [Q15526-2]

PTM databases

iPTMnetⁱ	Q15526
PhosphoSitePlusⁱ	Q15526

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148290
CleanExⁱ	HS_SURF1
ExpressionAtlasⁱ	Q15526 baseline and differential
Genevisibleⁱ	Q15526 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB033946

HPAⁱ

CAB033946

Interactionⁱ

Subunit structureⁱ

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14. Interacts with COA3.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
COA3	Q9Y2R0	6	EBI-3915286,EBI-6570446

With

Entry

#Exp.

IntAct

Notes

COA3

Q9Y2R0

6

EBI-3915286,EBI-6570446

Protein-protein interaction databases

BioGridⁱ	112701, 25 interactors
CORUMⁱ	Q15526
IntActⁱ	Q15526, 6 interactors
STRINGⁱ	9606.ENSP00000361042

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15526
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SURF1 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410KC4M Eukaryota COG3346 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064194
HOGENOMⁱ	HOG000097776
HOVERGENⁱ	HBG058486
InParanoidⁱ	Q15526
KEGG Orthology (KO) More...KOⁱ	K14998
OMAⁱ	WYSRDVA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IWR
PhylomeDBⁱ	Q15526
TreeFamⁱ	TF314684

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06662 SURF1, 1 hit
InterProⁱ	View protein in InterPro IPR002994 Surf1/Shy1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02104 SURF1, 1 hit
PROSITEⁱ	View protein in PROSITE PS50895 SURF1, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q15526-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAALQLG LRAAGLGRAP ASAAWRSVLR VSPRPGVAWR PSRCGSSAAE 
        60         70         80         90        100
ASATKAEDDS FLQWVLLLIP VTAFGLGTWQ VQRRKWKLNL IAELESRVLA 
       110        120        130        140        150
EPVPLPADPM ELKNLEYRPV KVRGCFDHSK ELYMMPRTMV DPVREAREGG 
       160        170        180        190        200
LISSSTQSGA YVVTPFHCTD LGVTILVNRG FVPRKKVNPE TRQKGQIEGE 
       210        220        230        240        250
VDLIGMVRLT ETRQPFVPEN NPERNHWHYR DLEAMARITG AEPIFIDANF 
       260        270        280        290        300
QSTVPGGPIG GQTRVTLRNE HLQYIVTWYG LSAATSYLWF KKFLRGTPGV

Length:300

Mass (Da):33,331

Last modified:November 1, 1996 - v1

Checksum:ⁱEC890EA48A0EDE7A

GO

Isoform 2 (identifier: Q15526-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
173-184: Missing.

« Hide

        10         20         30         40         50
MAAVAALQLG LRAAGLGRAP ASAAWRSVLR VSPRPGVAWR PSRCGSSAAE 
        60         70         80         90        100
ASATKAEDDS FLQWVLLLIP VTAFGLGTWQ VQRRKWKLNL IAELESRVLA 
       110        120        130        140        150
EPVPLPADPM ELKNLEYRPV KVRGCFDHSK ELYMMPRTMV DPVREAREGG 
       160        170        180        190        200
LISSSTQSGA YVVTPFHCTD LGKKVNPETR QKGQIEGEVD LIGMVRLTET 
       210        220        230        240        250
RQPFVPENNP ERNHWHYRDL EAMARITGAE PIFIDANFQS TVPGGPIGGQ 
       260        270        280 
TRVTLRNEHL QYIVTWYGLS AATSYLWFKK FLRGTPGV

Note: No experimental confirmation available.

Show »

Length:288

Mass (Da):31,979

Checksum:ⁱFF30182CA2C1EE6C

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_068648	56	A → G Found in a patient with LS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs116779216EnsemblClinVar.	1
Natural variantⁱVAR_036340	89	N → K in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_068649	90	L → P in LS. 1 PublicationCorresponds to variant dbSNP:rs782024654EnsemblClinVar.	1
Natural variantⁱVAR_007450	124	G → E in LS. 1 PublicationCorresponds to variant dbSNP:rs28933402EnsemblClinVar.	1
Natural variantⁱVAR_015258	124	G → R in LS. Corresponds to variant dbSNP:rs782033035Ensembl.	1
Natural variantⁱVAR_068650	177	V → G in LS. 1 Publication	1
Natural variantⁱVAR_076315	192	R → W in CMT4K; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs782190413EnsemblClinVar.	1
Natural variantⁱVAR_007451	202	D → H1 PublicationCorresponds to variant dbSNP:rs72619327EnsemblClinVar.	1
Natural variantⁱVAR_068651	205	G → E in LS. 1 Publication	1
Natural variantⁱVAR_068682	227	W → R in LS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398122806EnsemblClinVar.	1
Natural variantⁱVAR_068652	235	M → T in LS. 1 Publication	1
Natural variantⁱVAR_007452	246	I → T in LS. 1 Publication	1
Natural variantⁱVAR_068653	248	A → D in LS. 1 Publication	1
Natural variantⁱVAR_068654	257	G → R in LS. 1 Publication	1
Natural variantⁱVAR_015259	274	Y → D in LS. 1 PublicationCorresponds to variant dbSNP:rs121918658EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_034817	173 – 184	Missing in isoform 2. CuratedAdd BLAST		12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z35093 mRNA Translation: CAA84476.1 AK291122 mRNA Translation: BAF83811.1 AL158826 Genomic DNA Translation: CAI12836.1 AL158826 Genomic DNA Translation: CAI12837.1 BC028314 mRNA Translation: AAH28314.1 BC071658 mRNA Translation: AAH71658.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6966.1 [Q15526-1]
PIRⁱ	S57749
NCBI Reference Sequences More...RefSeqⁱ	NP_001267716.1, NM_001280787.1 NP_003163.1, NM_003172.3 [Q15526-1]
UniGeneⁱ	Hs.512464

Genome annotation databases

Ensemblⁱ	ENST00000371974; ENSP00000361042; ENSG00000148290 [Q15526-1] ENST00000626663; ENSP00000487158; ENSG00000280627 [Q15526-1]
GeneIDⁱ	6834
KEGGⁱ	hsa:6834
UCSC genome browser More...UCSCⁱ	uc004cdh.3 human [Q15526-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q15526	SURF1-like protein		HUMAN		300
SURF1-like protein		HUMAN		191

Protein	Similar proteins		Species	Score	Length
Q15526	SURF1-like protein		HUMAN		300
UPI0003ABB981		MACFA		347
UPI000C2A9CC1		Ugandan red Colobus		347
SURF1-like protein		PONAB		305
UPI00083F83C4		CALJA		305
+43

Protein	Similar proteins		Species	Score	Length
Q15526	SURF1-like protein		HUMAN		300
UPI000C2A9CC1		Ugandan red Colobus		347
UPI0003ABB981		MACFA		347
SURF1-like protein		PONAB		305
UPI00083F83C4		CALJA		305
+84

Cross-referencesⁱ

Web resourcesⁱ

Surfeit 1 (SURF1)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z35093 mRNA Translation: CAA84476.1 AK291122 mRNA Translation: BAF83811.1 AL158826 Genomic DNA Translation: CAI12836.1 AL158826 Genomic DNA Translation: CAI12837.1 BC028314 mRNA Translation: AAH28314.1 BC071658 mRNA Translation: AAH71658.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6966.1 [Q15526-1]
PIRⁱ	S57749
NCBI Reference Sequences More...RefSeqⁱ	NP_001267716.1, NM_001280787.1 NP_003163.1, NM_003172.3 [Q15526-1]
UniGeneⁱ	Hs.512464

3D structure databases

ProteinModelPortalⁱ	Q15526
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112701, 25 interactors
CORUMⁱ	Q15526
IntActⁱ	Q15526, 6 interactors
STRINGⁱ	9606.ENSP00000361042

PTM databases

iPTMnetⁱ	Q15526
PhosphoSitePlusⁱ	Q15526

Polymorphism and mutation databases

DMDMⁱ	2498973

DMDMⁱ

2498973

Proteomic databases

EPDⁱ	Q15526
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15526
PaxDbⁱ	Q15526
PeptideAtlas More...PeptideAtlasⁱ	Q15526
PRIDEⁱ	Q15526
ProteomicsDBⁱ	60616 60617 [Q15526-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6834
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371974; ENSP00000361042; ENSG00000148290 [Q15526-1] ENST00000626663; ENSP00000487158; ENSG00000280627 [Q15526-1]
GeneIDⁱ	6834
KEGGⁱ	hsa:6834
UCSC genome browser More...UCSCⁱ	uc004cdh.3 human [Q15526-1]

Organism-specific databases

CTDⁱ	6834
DisGeNET More...DisGeNETⁱ	6834
EuPathDBⁱ	HostDB:ENSG00000148290.9
GeneCardsⁱ	SURF1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11474 SURF1
Human Protein Atlas More...HPAⁱ	CAB033946
MalaCards human disease database More...MalaCardsⁱ	SURF1
MIMⁱ	185620 gene 256000 phenotype 616684 phenotype
neXtProtⁱ	NX_Q15526
Open Targets More...OpenTargetsⁱ	ENSG00000148290
Orphanetⁱ	1561 Fatal infantile cytochrome C oxidase deficiency 70474 Leigh syndrome with cardiomyopathy 255241 Leigh syndrome with leukodystrophy 391351 SURF1-related Charcot-Marie-Tooth disease type 4
PharmGKBⁱ	PA36259
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410KC4M Eukaryota COG3346 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064194
HOGENOMⁱ	HOG000097776
HOVERGENⁱ	HBG058486
InParanoidⁱ	Q15526
KEGG Orthology (KO) More...KOⁱ	K14998
OMAⁱ	WYSRDVA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IWR
PhylomeDBⁱ	Q15526
TreeFamⁱ	TF314684

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-611105 Respiratory electron transport
SIGNORⁱ	Q15526

Miscellaneous databases

GeneWikiⁱ	SURF1
GenomeRNAiⁱ	6834
Protein Ontology More...PROⁱ	PR:Q15526
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148290
CleanExⁱ	HS_SURF1
ExpressionAtlasⁱ	Q15526 baseline and differential
Genevisibleⁱ	Q15526 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06662 SURF1, 1 hit
InterProⁱ	View protein in InterPro IPR002994 Surf1/Shy1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02104 SURF1, 1 hit
PROSITEⁱ	View protein in PROSITE PS50895 SURF1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SURF1_HUMAN
Accessionⁱ	Q15526Primary (citable) accession number: Q15526 Secondary accession number(s): Q5T8T3, Q5T8T4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	June 20, 2018
	This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q15526 (SURF1_HUMAN)

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Surfeit locus protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ