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Protein

Sperm surface protein Sp17

Gene

SPA17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calmodulin binding Source: GO_Central

GO - Biological processi

  • binding of sperm to zona pellucida Source: InterPro
  • epithelial cilium movement Source: BHF-UCL
  • single fertilization Source: ProtInc
  • spermatogenesis Source: ProtInc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sperm surface protein Sp17
Alternative name(s):
Cancer/testis antigen 22
Short name:
CT22
Sp17-1
Sperm autoantigenic protein 17
Short name:
Sperm protein 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPA17
Synonyms:SP17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000064199.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11210 SPA17

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608621 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15506

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
53340

Open Targets

More...
OpenTargetsi
ENSG00000064199

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36047

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPA17

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2833264

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001813401 – 151Sperm surface protein Sp17Add BLAST151

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15506

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15506

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15506

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15506

PeptideAtlas

More...
PeptideAtlasi
Q15506

PRoteomics IDEntifications database

More...
PRIDEi
Q15506

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60613

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q15506

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15506

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15506

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis and sperm specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000064199 Expressed in 184 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_SPA17

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15506 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15506 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037568

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). May interact with ROPN1.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119741, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q15506, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000227135

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15506

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15506

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini114 – 143IQPROSITE-ProRule annotationAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IX7J Eukaryota
ENOG410XXA6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000039164

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059525

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003879

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15506

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKEQEPP

Database of Orthologous Groups

More...
OrthoDBi
1255894at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15506

TreeFam database of animal gene trees

More...
TreeFami
TF332959

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
IPR000048 IQ_motif_EF-hand-BS
IPR012105 Sp17

The PANTHER Classification System

More...
PANTHERi
PTHR10699:SF16 PTHR10699:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612 IQ, 1 hit
PF02197 RIIa, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016533 Sp17, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 1 hit
SM00394 RIIa, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q15506-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFESLLEKR
60 70 80 90 100
EKTNFDPAEW GSKVEDRFYN NHAFEEQEPP EKSDPKQEES QISGKEEETS
110 120 130 140 150
VTILDSSEED KEKEEVAAVK IQAAFRGHIA REEAKKMKTN SLQNEEKEEN

K
Length:151
Mass (Da):17,406
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC99EC310FA0E54A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z48570 mRNA Translation: CAA88459.1
AF334735 mRNA Translation: AAK20878.1
AF334810 Genomic DNA Translation: AAK28125.1
AK311806 mRNA Translation: BAG34749.1
CH471065 Genomic DNA Translation: EAW67592.1
BC032457 mRNA Translation: AAH32457.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8450.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38243

NCBI Reference Sequences

More...
RefSeqi
NP_059121.1, NM_017425.3
XP_011541172.1, XM_011542870.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.286233

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000227135; ENSP00000227135; ENSG00000064199
ENST00000532692; ENSP00000432305; ENSG00000064199

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
53340

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:53340

UCSC genome browser

More...
UCSCi
uc001qap.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48570 mRNA Translation: CAA88459.1
AF334735 mRNA Translation: AAK20878.1
AF334810 Genomic DNA Translation: AAK28125.1
AK311806 mRNA Translation: BAG34749.1
CH471065 Genomic DNA Translation: EAW67592.1
BC032457 mRNA Translation: AAH32457.1
CCDSiCCDS8450.1
PIRiI38243
RefSeqiNP_059121.1, NM_017425.3
XP_011541172.1, XM_011542870.2
UniGeneiHs.286233

3D structure databases

ProteinModelPortaliQ15506
SMRiQ15506
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119741, 13 interactors
IntActiQ15506, 5 interactors
STRINGi9606.ENSP00000227135

PTM databases

iPTMnetiQ15506
PhosphoSitePlusiQ15506

Polymorphism and mutation databases

BioMutaiSPA17
DMDMi2833264

Proteomic databases

EPDiQ15506
jPOSTiQ15506
MaxQBiQ15506
PaxDbiQ15506
PeptideAtlasiQ15506
PRIDEiQ15506
ProteomicsDBi60613
TopDownProteomicsiQ15506

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
53340
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227135; ENSP00000227135; ENSG00000064199
ENST00000532692; ENSP00000432305; ENSG00000064199
GeneIDi53340
KEGGihsa:53340
UCSCiuc001qap.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
53340
DisGeNETi53340
EuPathDBiHostDB:ENSG00000064199.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPA17
HGNCiHGNC:11210 SPA17
HPAiHPA037568
MIMi608621 gene
neXtProtiNX_Q15506
OpenTargetsiENSG00000064199
PharmGKBiPA36047

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IX7J Eukaryota
ENOG410XXA6 LUCA
GeneTreeiENSGT00440000039164
HOGENOMiHOG000059525
HOVERGENiHBG003879
InParanoidiQ15506
OMAiFKEQEPP
OrthoDBi1255894at2759
PhylomeDBiQ15506
TreeFamiTF332959

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SPA17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
53340

Protein Ontology

More...
PROi
PR:Q15506

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000064199 Expressed in 184 organ(s), highest expression level in testis
CleanExiHS_SPA17
ExpressionAtlasiQ15506 baseline and differential
GenevisibleiQ15506 HS

Family and domain databases

InterProiView protein in InterPro
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
IPR000048 IQ_motif_EF-hand-BS
IPR012105 Sp17
PANTHERiPTHR10699:SF16 PTHR10699:SF16, 1 hit
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF02197 RIIa, 1 hit
PIRSFiPIRSF016533 Sp17, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00394 RIIa, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSP17_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15506
Secondary accession number(s): B2R4F2, Q9BXF7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 16, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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