UniProtKB - Q15506 (SP17_HUMAN)
Protein
Sperm surface protein Sp17
Gene
SPA17
Organism
Homo sapiens (Human)
Status
Functioni
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).By similarity
GO - Molecular functioni
- calmodulin binding Source: GO_Central
GO - Biological processi
- binding of sperm to zona pellucida Source: InterPro
- epithelial cilium movement involved in extracellular fluid movement Source: BHF-UCL
- single fertilization Source: ProtInc
- spermatogenesis Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | Q15506 |
Names & Taxonomyi
Protein namesi | Recommended name: Sperm surface protein Sp17Alternative name(s): Cancer/testis antigen 22 Short name: CT22 Sp17-1 Sperm autoantigenic protein 17 Short name: Sperm protein 17 |
Gene namesi | Name:SPA17 Synonyms:SP17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11210, SPA17 |
MIMi | 608621, gene |
neXtProti | NX_Q15506 |
VEuPathDBi | HostDB:ENSG00000064199.6 |
Subcellular locationi
Other locations
- Membrane Curated; Peripheral membrane protein Curated
Extracellular region or secreted
- extracellular region Source: GOC
Plasma Membrane
- external side of plasma membrane Source: Ensembl
Other locations
- cilium Source: BHF-UCL
- cytoplasm Source: BHF-UCL
- motile cilium Source: BHF-UCL
- sperm fibrous sheath Source: GO_Central
- sperm principal piece Source: GO_Central
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 53340 |
OpenTargetsi | ENSG00000064199 |
PharmGKBi | PA36047 |
Miscellaneous databases
Pharosi | Q15506, Tbio |
Genetic variation databases
BioMutai | SPA17 |
DMDMi | 2833264 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181340 | 1 – 151 | Sperm surface protein Sp17Add BLAST | 151 |
Proteomic databases
EPDi | Q15506 |
jPOSTi | Q15506 |
MassIVEi | Q15506 |
MaxQBi | Q15506 |
PaxDbi | Q15506 |
PeptideAtlasi | Q15506 |
PRIDEi | Q15506 |
ProteomicsDBi | 60613 |
TopDownProteomicsi | Q15506 |
PTM databases
iPTMneti | Q15506 |
PhosphoSitePlusi | Q15506 |
Expressioni
Tissue specificityi
Testis and sperm specific.
Gene expression databases
Bgeei | ENSG00000064199, Expressed in testis and 195 other tissues |
ExpressionAtlasi | Q15506, baseline and differential |
Genevisiblei | Q15506, HS |
Organism-specific databases
HPAi | ENSG00000064199, Tissue enhanced (fallopian tube, testis) |
Interactioni
Subunit structurei
Homodimer (By similarity). May interact with ROPN1.
By similarityBinary interactionsi
Hide detailsQ15506
GO - Molecular functioni
- calmodulin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119741, 15 interactors |
IntActi | Q15506, 11 interactors |
STRINGi | 9606.ENSP00000432305 |
Miscellaneous databases
RNActi | Q15506, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 114 – 143 | IQPROSITE-ProRule annotationAdd BLAST | 30 |
Phylogenomic databases
eggNOGi | ENOG502S4R6, Eukaryota |
GeneTreei | ENSGT00440000039164 |
HOGENOMi | CLU_115900_0_0_1 |
InParanoidi | Q15506 |
OMAi | DMEENAA |
OrthoDBi | 1255894at2759 |
PhylomeDBi | Q15506 |
TreeFami | TF332959 |
Family and domain databases
InterProi | View protein in InterPro IPR003117, cAMP_dep_PK_reg_su_I/II_a/b IPR000048, IQ_motif_EF-hand-BS IPR012105, Sp17 |
Pfami | View protein in Pfam PF00612, IQ, 1 hit PF02197, RIIa, 1 hit |
PIRSFi | PIRSF016533, Sp17, 1 hit |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00394, RIIa, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit |
i Sequence
Sequence statusi: Complete.
Q15506-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFESLLEKR
60 70 80 90 100
EKTNFDPAEW GSKVEDRFYN NHAFEEQEPP EKSDPKQEES QISGKEEETS
110 120 130 140 150
VTILDSSEED KEKEEVAAVK IQAAFRGHIA REEAKKMKTN SLQNEEKEEN
K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48570 mRNA Translation: CAA88459.1 AF334735 mRNA Translation: AAK20878.1 AF334810 Genomic DNA Translation: AAK28125.1 AK311806 mRNA Translation: BAG34749.1 CH471065 Genomic DNA Translation: EAW67592.1 BC032457 mRNA Translation: AAH32457.1 |
CCDSi | CCDS8450.1 |
PIRi | I38243 |
RefSeqi | NP_059121.1, NM_017425.3 XP_011541172.1, XM_011542870.2 |
Genome annotation databases
Ensembli | ENST00000227135; ENSP00000227135; ENSG00000064199 ENST00000532692; ENSP00000432305; ENSG00000064199 |
GeneIDi | 53340 |
KEGGi | hsa:53340 |
UCSCi | uc001qap.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48570 mRNA Translation: CAA88459.1 AF334735 mRNA Translation: AAK20878.1 AF334810 Genomic DNA Translation: AAK28125.1 AK311806 mRNA Translation: BAG34749.1 CH471065 Genomic DNA Translation: EAW67592.1 BC032457 mRNA Translation: AAH32457.1 |
CCDSi | CCDS8450.1 |
PIRi | I38243 |
RefSeqi | NP_059121.1, NM_017425.3 XP_011541172.1, XM_011542870.2 |
3D structure databases
SMRi | Q15506 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119741, 15 interactors |
IntActi | Q15506, 11 interactors |
STRINGi | 9606.ENSP00000432305 |
PTM databases
iPTMneti | Q15506 |
PhosphoSitePlusi | Q15506 |
Genetic variation databases
BioMutai | SPA17 |
DMDMi | 2833264 |
Proteomic databases
EPDi | Q15506 |
jPOSTi | Q15506 |
MassIVEi | Q15506 |
MaxQBi | Q15506 |
PaxDbi | Q15506 |
PeptideAtlasi | Q15506 |
PRIDEi | Q15506 |
ProteomicsDBi | 60613 |
TopDownProteomicsi | Q15506 |
Protocols and materials databases
Antibodypediai | 32898, 253 antibodies |
DNASUi | 53340 |
Genome annotation databases
Ensembli | ENST00000227135; ENSP00000227135; ENSG00000064199 ENST00000532692; ENSP00000432305; ENSG00000064199 |
GeneIDi | 53340 |
KEGGi | hsa:53340 |
UCSCi | uc001qap.4, human |
Organism-specific databases
CTDi | 53340 |
DisGeNETi | 53340 |
GeneCardsi | SPA17 |
HGNCi | HGNC:11210, SPA17 |
HPAi | ENSG00000064199, Tissue enhanced (fallopian tube, testis) |
MIMi | 608621, gene |
neXtProti | NX_Q15506 |
OpenTargetsi | ENSG00000064199 |
PharmGKBi | PA36047 |
VEuPathDBi | HostDB:ENSG00000064199.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4R6, Eukaryota |
GeneTreei | ENSGT00440000039164 |
HOGENOMi | CLU_115900_0_0_1 |
InParanoidi | Q15506 |
OMAi | DMEENAA |
OrthoDBi | 1255894at2759 |
PhylomeDBi | Q15506 |
TreeFami | TF332959 |
Enzyme and pathway databases
PathwayCommonsi | Q15506 |
Miscellaneous databases
BioGRID-ORCSi | 53340, 9 hits in 854 CRISPR screens |
ChiTaRSi | SPA17, human |
GeneWikii | SPA17 |
GenomeRNAii | 53340 |
Pharosi | Q15506, Tbio |
PROi | PR:Q15506 |
RNActi | Q15506, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000064199, Expressed in testis and 195 other tissues |
ExpressionAtlasi | Q15506, baseline and differential |
Genevisiblei | Q15506, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003117, cAMP_dep_PK_reg_su_I/II_a/b IPR000048, IQ_motif_EF-hand-BS IPR012105, Sp17 |
Pfami | View protein in Pfam PF00612, IQ, 1 hit PF02197, RIIa, 1 hit |
PIRSFi | PIRSF016533, Sp17, 1 hit |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00394, RIIa, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SP17_HUMAN | |
Accessioni | Q15506Primary (citable) accession number: Q15506 Secondary accession number(s): B2R4F2, Q9BXF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot