SPA17

Functionⁱ

Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).By similarity

GO - Biological processⁱ

binding of sperm to zona pellucida Source: InterPro
epithelial cilium movement
Source: BHF-UCL
Non-traceable author statementⁱ
- 18421703
single fertilization
Source: ProtInc
Traceable author statementⁱ
- 8688458
spermatogenesis
Source: ProtInc
Traceable author statementⁱ
- 8688458

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sperm surface protein Sp17 Alternative name(s): Cancer/testis antigen 22 Short name: CT22 Sp17-1 Sperm autoantigenic protein 17 Short name: Sperm protein 17
Gene namesⁱ	Name:SPA17 Synonyms:SP17
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000064199.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11210 SPA17
MIMⁱ	608621 gene
neXtProtⁱ	NX_Q15506

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	53340
Open Targets More...OpenTargetsⁱ	ENSG00000064199
PharmGKBⁱ	PA36047

Polymorphism and mutation databases

BioMutaⁱ	SPA17
DMDMⁱ	2833264

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000181340	1 – 151	Sperm surface protein Sp17Add BLAST		151

Proteomic databases

EPDⁱ	Q15506
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15506
PaxDbⁱ	Q15506
PeptideAtlas More...PeptideAtlasⁱ	Q15506
PRIDEⁱ	Q15506
ProteomicsDBⁱ	60613
TopDownProteomicsⁱ	Q15506

PTM databases

iPTMnetⁱ	Q15506
PhosphoSitePlusⁱ	Q15506

Expressionⁱ

Tissue specificityⁱ

Testis and sperm specific.

Gene expression databases

Bgeeⁱ	ENSG00000064199 Expressed in 184 organ(s), highest expression level in testis
CleanExⁱ	HS_SPA17
ExpressionAtlasⁱ	Q15506 baseline and differential
Genevisibleⁱ	Q15506 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037568

HPAⁱ

HPA037568

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). May interact with ROPN1.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ACTN2	P35609	3	EBI-1377865,EBI-77797
AKAP7	O43687-2	5	EBI-1377865,EBI-10185182
MYL6B	P14649	7	EBI-1377865,EBI-358570
ROPN1	Q9HAT0	8	EBI-1377865,EBI-1378139

Protein-protein interaction databases

BioGridⁱ	119741, 13 interactors
IntActⁱ	Q15506, 5 interactors
STRINGⁱ	9606.ENSP00000227135

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15506
SMRⁱ	Q15506
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	114 – 143	IQPROSITE-ProRule annotationAdd BLAST		30

Phylogenomic databases

eggNOGⁱ	ENOG410IX7J Eukaryota ENOG410XXA6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039164
HOGENOMⁱ	HOG000059525
HOVERGENⁱ	HBG003879
InParanoidⁱ	Q15506
OMAⁱ	FKEQEPP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G18VB
PhylomeDBⁱ	Q15506
TreeFamⁱ	TF332959

Family and domain databases

InterProⁱ	View protein in InterPro IPR003117 cAMP_dep_PK_reg_su_I/II_a/b IPR000048 IQ_motif_EF-hand-BS IPR012105 Sp17
PANTHERⁱ	PTHR10699:SF16 PTHR10699:SF16, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00612 IQ, 1 hit PF02197 RIIa, 1 hit
PIRSFⁱ	PIRSF016533 Sp17, 1 hit
SMARTⁱ	View protein in SMART SM00015 IQ, 1 hit SM00394 RIIa, 1 hit
PROSITEⁱ	View protein in PROSITE PS50096 IQ, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q15506-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFESLLEKR 
        60         70         80         90        100
EKTNFDPAEW GSKVEDRFYN NHAFEEQEPP EKSDPKQEES QISGKEEETS 
       110        120        130        140        150
VTILDSSEED KEKEEVAAVK IQAAFRGHIA REEAKKMKTN SLQNEEKEEN 

K

Length:151

Mass (Da):17,406

Last modified:November 1, 1996 - v1

Checksum:ⁱBC99EC310FA0E54A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z48570 mRNA Translation: CAA88459.1 AF334735 mRNA Translation: AAK20878.1 AF334810 Genomic DNA Translation: AAK28125.1 AK311806 mRNA Translation: BAG34749.1 CH471065 Genomic DNA Translation: EAW67592.1 BC032457 mRNA Translation: AAH32457.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8450.1
PIRⁱ	I38243
NCBI Reference Sequences More...RefSeqⁱ	NP_059121.1, NM_017425.3 XP_011541172.1, XM_011542870.2
UniGeneⁱ	Hs.286233

Genome annotation databases

Ensemblⁱ	ENST00000227135; ENSP00000227135; ENSG00000064199 ENST00000532692; ENSP00000432305; ENSG00000064199
GeneIDⁱ	53340
KEGGⁱ	hsa:53340
UCSC genome browser More...UCSCⁱ	uc001qap.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15506	Sperm protein 17 (Fragment)		HUMAN		151	UniRef100_Q15506
Sperm surface protein Sp17		PANTR		151

Protein	Similar proteins		Species	Score	Length	Source
Q15506	Sperm surface protein Sp17		PAPHA		163	UniRef90_Q15506
Sperm surface protein Sp17		MACFA		151
Sperm protein 17 (Fragment)		HUMAN		151
Sperm surface protein Sp17		PANTR		151
Sperm surface protein Sp17		PAPAN		163
+28

Protein	Similar proteins		Species	Score	Length	Source
Q15506	Sperm surface protein Sp17		PAPHA		163	UniRef50_Q15506
Sperm surface protein Sp17		MACFA		151
Sperm surface protein Sp17		MONDO		179
Sperm protein 17 (Fragment)		HUMAN		151
Sperm surface protein Sp17		PANTR		151
+36

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z48570 mRNA Translation: CAA88459.1 AF334735 mRNA Translation: AAK20878.1 AF334810 Genomic DNA Translation: AAK28125.1 AK311806 mRNA Translation: BAG34749.1 CH471065 Genomic DNA Translation: EAW67592.1 BC032457 mRNA Translation: AAH32457.1
CCDSⁱ	CCDS8450.1
PIRⁱ	I38243
RefSeqⁱ	NP_059121.1, NM_017425.3 XP_011541172.1, XM_011542870.2
UniGeneⁱ	Hs.286233

3D structure databases

ProteinModelPortalⁱ	Q15506
SMRⁱ	Q15506
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119741, 13 interactors
IntActⁱ	Q15506, 5 interactors
STRINGⁱ	9606.ENSP00000227135

PTM databases

iPTMnetⁱ	Q15506
PhosphoSitePlusⁱ	Q15506

Polymorphism and mutation databases

BioMutaⁱ	SPA17
DMDMⁱ	2833264

Proteomic databases

EPDⁱ	Q15506
MaxQBⁱ	Q15506
PaxDbⁱ	Q15506
PeptideAtlasⁱ	Q15506
PRIDEⁱ	Q15506
ProteomicsDBⁱ	60613
TopDownProteomicsⁱ	Q15506

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	53340
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000227135; ENSP00000227135; ENSG00000064199 ENST00000532692; ENSP00000432305; ENSG00000064199
GeneIDⁱ	53340
KEGGⁱ	hsa:53340
UCSCⁱ	uc001qap.4 human

Organism-specific databases

CTDⁱ	53340
DisGeNETⁱ	53340
EuPathDBⁱ	HostDB:ENSG00000064199.6
GeneCardsⁱ	SPA17
HGNCⁱ	HGNC:11210 SPA17
HPAⁱ	HPA037568
MIMⁱ	608621 gene
neXtProtⁱ	NX_Q15506
OpenTargetsⁱ	ENSG00000064199
PharmGKBⁱ	PA36047
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IX7J Eukaryota ENOG410XXA6 LUCA
GeneTreeⁱ	ENSGT00440000039164
HOGENOMⁱ	HOG000059525
HOVERGENⁱ	HBG003879
InParanoidⁱ	Q15506
OMAⁱ	FKEQEPP
OrthoDBⁱ	EOG091G18VB
PhylomeDBⁱ	Q15506
TreeFamⁱ	TF332959

Miscellaneous databases

GeneWikiⁱ	SPA17
GenomeRNAiⁱ	53340
Protein Ontology More...PROⁱ	PR:Q15506
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000064199 Expressed in 184 organ(s), highest expression level in testis
CleanExⁱ	HS_SPA17
ExpressionAtlasⁱ	Q15506 baseline and differential
Genevisibleⁱ	Q15506 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003117 cAMP_dep_PK_reg_su_I/II_a/b IPR000048 IQ_motif_EF-hand-BS IPR012105 Sp17
PANTHERⁱ	PTHR10699:SF16 PTHR10699:SF16, 1 hit
Pfamⁱ	View protein in Pfam PF00612 IQ, 1 hit PF02197 RIIa, 1 hit
PIRSFⁱ	PIRSF016533 Sp17, 1 hit
SMARTⁱ	View protein in SMART SM00015 IQ, 1 hit SM00394 RIIa, 1 hit
PROSITEⁱ	View protein in PROSITE PS50096 IQ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SP17_HUMAN
Accessionⁱ	Q15506Primary (citable) accession number: Q15506 Secondary accession number(s): B2R4F2, Q9BXF7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q15506 (SP17_HUMAN)

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Sperm surface protein Sp17

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ