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Protein

Sperm surface protein Sp17

Gene

SPA17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).By similarity

GO - Molecular functioni

  • calmodulin binding Source: GO_Central

GO - Biological processi

  • binding of sperm to zona pellucida Source: InterPro
  • epithelial cilium movement Source: BHF-UCL
  • single fertilization Source: ProtInc
  • spermatogenesis Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm surface protein Sp17
Alternative name(s):
Cancer/testis antigen 22
Short name:
CT22
Sp17-1
Sperm autoantigenic protein 17
Short name:
Sperm protein 17
Gene namesi
Name:SPA17
Synonyms:SP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000064199.6
HGNCiHGNC:11210 SPA17
MIMi608621 gene
neXtProtiNX_Q15506

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53340
OpenTargetsiENSG00000064199
PharmGKBiPA36047

Polymorphism and mutation databases

BioMutaiSPA17
DMDMi2833264

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001813401 – 151Sperm surface protein Sp17Add BLAST151

Proteomic databases

EPDiQ15506
MaxQBiQ15506
PaxDbiQ15506
PeptideAtlasiQ15506
PRIDEiQ15506
ProteomicsDBi60613
TopDownProteomicsiQ15506

PTM databases

iPTMnetiQ15506
PhosphoSitePlusiQ15506

Expressioni

Tissue specificityi

Testis and sperm specific.

Gene expression databases

BgeeiENSG00000064199 Expressed in 184 organ(s), highest expression level in testis
CleanExiHS_SPA17
ExpressionAtlasiQ15506 baseline and differential
GenevisibleiQ15506 HS

Organism-specific databases

HPAiHPA037568

Interactioni

Subunit structurei

Homodimer (By similarity). May interact with ROPN1.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119741, 13 interactors
IntActiQ15506, 5 interactors
STRINGi9606.ENSP00000227135

Structurei

3D structure databases

ProteinModelPortaliQ15506
SMRiQ15506
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 143IQPROSITE-ProRule annotationAdd BLAST30

Phylogenomic databases

eggNOGiENOG410IX7J Eukaryota
ENOG410XXA6 LUCA
GeneTreeiENSGT00440000039164
HOGENOMiHOG000059525
HOVERGENiHBG003879
InParanoidiQ15506
OMAiFKEQEPP
OrthoDBiEOG091G18VB
PhylomeDBiQ15506
TreeFamiTF332959

Family and domain databases

InterProiView protein in InterPro
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
IPR000048 IQ_motif_EF-hand-BS
IPR012105 Sp17
PANTHERiPTHR10699:SF16 PTHR10699:SF16, 1 hit
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF02197 RIIa, 1 hit
PIRSFiPIRSF016533 Sp17, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00394 RIIa, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q15506-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFESLLEKR
60 70 80 90 100
EKTNFDPAEW GSKVEDRFYN NHAFEEQEPP EKSDPKQEES QISGKEEETS
110 120 130 140 150
VTILDSSEED KEKEEVAAVK IQAAFRGHIA REEAKKMKTN SLQNEEKEEN

K
Length:151
Mass (Da):17,406
Last modified:November 1, 1996 - v1
Checksum:iBC99EC310FA0E54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48570 mRNA Translation: CAA88459.1
AF334735 mRNA Translation: AAK20878.1
AF334810 Genomic DNA Translation: AAK28125.1
AK311806 mRNA Translation: BAG34749.1
CH471065 Genomic DNA Translation: EAW67592.1
BC032457 mRNA Translation: AAH32457.1
CCDSiCCDS8450.1
PIRiI38243
RefSeqiNP_059121.1, NM_017425.3
XP_011541172.1, XM_011542870.2
UniGeneiHs.286233

Genome annotation databases

EnsembliENST00000227135; ENSP00000227135; ENSG00000064199
ENST00000532692; ENSP00000432305; ENSG00000064199
GeneIDi53340
KEGGihsa:53340
UCSCiuc001qap.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48570 mRNA Translation: CAA88459.1
AF334735 mRNA Translation: AAK20878.1
AF334810 Genomic DNA Translation: AAK28125.1
AK311806 mRNA Translation: BAG34749.1
CH471065 Genomic DNA Translation: EAW67592.1
BC032457 mRNA Translation: AAH32457.1
CCDSiCCDS8450.1
PIRiI38243
RefSeqiNP_059121.1, NM_017425.3
XP_011541172.1, XM_011542870.2
UniGeneiHs.286233

3D structure databases

ProteinModelPortaliQ15506
SMRiQ15506
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119741, 13 interactors
IntActiQ15506, 5 interactors
STRINGi9606.ENSP00000227135

PTM databases

iPTMnetiQ15506
PhosphoSitePlusiQ15506

Polymorphism and mutation databases

BioMutaiSPA17
DMDMi2833264

Proteomic databases

EPDiQ15506
MaxQBiQ15506
PaxDbiQ15506
PeptideAtlasiQ15506
PRIDEiQ15506
ProteomicsDBi60613
TopDownProteomicsiQ15506

Protocols and materials databases

DNASUi53340
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227135; ENSP00000227135; ENSG00000064199
ENST00000532692; ENSP00000432305; ENSG00000064199
GeneIDi53340
KEGGihsa:53340
UCSCiuc001qap.4 human

Organism-specific databases

CTDi53340
DisGeNETi53340
EuPathDBiHostDB:ENSG00000064199.6
GeneCardsiSPA17
HGNCiHGNC:11210 SPA17
HPAiHPA037568
MIMi608621 gene
neXtProtiNX_Q15506
OpenTargetsiENSG00000064199
PharmGKBiPA36047
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX7J Eukaryota
ENOG410XXA6 LUCA
GeneTreeiENSGT00440000039164
HOGENOMiHOG000059525
HOVERGENiHBG003879
InParanoidiQ15506
OMAiFKEQEPP
OrthoDBiEOG091G18VB
PhylomeDBiQ15506
TreeFamiTF332959

Miscellaneous databases

GeneWikiiSPA17
GenomeRNAii53340
PROiPR:Q15506
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064199 Expressed in 184 organ(s), highest expression level in testis
CleanExiHS_SPA17
ExpressionAtlasiQ15506 baseline and differential
GenevisibleiQ15506 HS

Family and domain databases

InterProiView protein in InterPro
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
IPR000048 IQ_motif_EF-hand-BS
IPR012105 Sp17
PANTHERiPTHR10699:SF16 PTHR10699:SF16, 1 hit
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF02197 RIIa, 1 hit
PIRSFiPIRSF016533 Sp17, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00394 RIIa, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSP17_HUMAN
AccessioniPrimary (citable) accession number: Q15506
Secondary accession number(s): B2R4F2, Q9BXF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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