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Protein

Putative inactive beta-glucuronidase-like protein SMA3

Gene

GUSBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene. Compared to other members of the glycosyl hydrolase 2 family this putative protein is truncated in both the N- and C-terminal regions and thus probably lacks enzymatic activity.Curated

GO - Biological processi

  • nervous system development Source: ProtInc
  • skeletal system development Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive beta-glucuronidase-like protein SMA3
Gene namesi
Name:GUSBP1
Synonyms:SMA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13670 GUSBP1
neXtProtiNX_Q15486

Pathology & Biotechi

Organism-specific databases

DisGeNETi100653061
728411

Polymorphism and mutation databases

DMDMi205371787

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000576821 – 140Putative inactive beta-glucuronidase-like protein SMA3Add BLAST140

Proteomic databases

PRIDEiQ15486
ProteomicsDBi60610

Expressioni

Tissue specificityi

Ubiquitous.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HOXA1P496394EBI-712457,EBI-740785

Protein-protein interaction databases

IntActiQ15486, 26 interactors

Structurei

3D structure databases

ProteinModelPortaliQ15486
SMRiQ15486
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Phylogenomic databases

HOVERGENiHBG051863
InParanoidiQ15486
PhylomeDBiQ15486

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF49303 SSF49303, 1 hit

Sequencei

Sequence statusi: Complete.

Q15486-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRSNPVKPA LDYFSNRLVN YQISVKCSNQ FKLEVCLLNA ENKVVDNQAG
60 70 80 90 100
TQGQLKVLGA NLWWPYLMHE HPASLYSWED GDCSHQSLGP LPACDLCDQL
110 120 130 140
HLRSRQGGSV CGCDPCEQLL LLVSQLRAPG VDSAAAGRPV
Length:140
Mass (Da):15,381
Last modified:September 2, 2008 - v3
Checksum:i80CA4B489C81A48D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15S → L in CAA58278 (PubMed:7977382).Curated1
Sequence conflicti74S → Y in CAA58278 (PubMed:7977382).Curated1
Sequence conflicti74S → Y in AAP35406 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83299 mRNA Translation: CAA58278.1
AK289832 mRNA Translation: BAF82521.1
AK315849 mRNA Translation: BAF98740.1
BT006760 mRNA Translation: AAP35406.1
AL009030 Genomic DNA Translation: CAC69829.1
AL009030 Genomic DNA Translation: CAC69830.1
PIRiI38232
RefSeqiXP_016885720.1, XM_017030231.1
XP_016885721.1, XM_017030232.1
XP_016885722.1, XM_017030233.1
UniGeneiHs.582500
Hs.631974
Hs.652536
Hs.654588

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83299 mRNA Translation: CAA58278.1
AK289832 mRNA Translation: BAF82521.1
AK315849 mRNA Translation: BAF98740.1
BT006760 mRNA Translation: AAP35406.1
AL009030 Genomic DNA Translation: CAC69829.1
AL009030 Genomic DNA Translation: CAC69830.1
PIRiI38232
RefSeqiXP_016885720.1, XM_017030231.1
XP_016885721.1, XM_017030232.1
XP_016885722.1, XM_017030233.1
UniGeneiHs.582500
Hs.631974
Hs.652536
Hs.654588

3D structure databases

ProteinModelPortaliQ15486
SMRiQ15486
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ15486, 26 interactors

Polymorphism and mutation databases

DMDMi205371787

Proteomic databases

PRIDEiQ15486
ProteomicsDBi60610

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi100653061
728411
GeneCardsiGUSBP1
HGNCiHGNC:13670 GUSBP1
neXtProtiNX_Q15486
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG051863
InParanoidiQ15486
PhylomeDBiQ15486

Miscellaneous databases

ChiTaRSiGUSBP1 human
GenomeRNAii100653061

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF49303 SSF49303, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGUSP1_HUMAN
AccessioniPrimary (citable) accession number: Q15486
Secondary accession number(s): A6NLY8
, A8K1B7, Q969T8, Q9BUH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: September 2, 2008
Last modified: November 7, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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