FCN2

Functionⁱ

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	249	CalciumCombined sources1 Publication	1
Metal bindingⁱ	251	CalciumCombined sources1 Publication	1
Metal bindingⁱ	253	Calcium; via carbonyl oxygenCombined sources1 Publication	1
Metal bindingⁱ	255	Calcium; via carbonyl oxygenCombined sources1 Publication	1

GO - Molecular functionⁱ

antigen binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8576206
calcium-dependent protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12421953
mannan binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8576206
metal ion binding Source: UniProtKB-KW
proteoglycan binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8576206
serine-type endopeptidase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

complement activation Source: Reactome
complement activation, lectin pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 14707097
- 15804047
defense response to Gram-negative bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 8576206
defense response to Gram-positive bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 14707097
opsonization
Source: UniProtKB
Inferred from direct assayⁱ
- 8576206
recognition of apoptotic cell
Source: UniProtKB
Inferred from direct assayⁱ
- 15804047

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Complement activation lectin pathway, Immunity, Innate immunity
Ligand	Calcium, Lectin, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166662 Lectin pathway of complement activation R-HSA-166663 Initial triggering of complement R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface

Reactomeⁱ

R-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement
R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface

Protein family/group databases

UniLectinⁱ	Q15485

UniLectinⁱ

Q15485

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ficolin-2 Alternative name(s): 37 kDa elastin-binding protein Collagen/fibrinogen domain-containing protein 2 EBP-37 Ficolin-B Ficolin-beta Hucolin L-ficolin Serum lectin p35
Gene namesⁱ	Name:FCN2 Synonyms:FCNL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160339.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3624 FCN2
MIMⁱ	601624 gene
neXtProtⁱ	NX_Q15485

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2220
Open Targets More...OpenTargetsⁱ	ENSG00000160339
PharmGKBⁱ	PA28070

Polymorphism and mutation databases

BioMutaⁱ	FCN2
DMDMⁱ	166214934

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000009139	26 – 313	Ficolin-2Add BLAST		288

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	77	Hydroxyproline1 Publication	1
Modified residueⁱ	80	Hydroxyproline1 Publication	1
Modified residueⁱ	86	Hydroxyproline1 Publication	1
Disulfide bondⁱ	98 ↔ 126	By similarity
Disulfide bondⁱ	105 ↔ 133	Combined sources1 Publication
Glycosylationⁱ	240	N-linked (GlcNAc...) asparagineSequence analysis1 Publication	1
Disulfide bondⁱ	257 ↔ 270	Combined sources1 Publication
Glycosylationⁱ	300	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15485
PaxDbⁱ	Q15485
PeptideAtlas More...PeptideAtlasⁱ	Q15485
PRIDEⁱ	Q15485
ProteomicsDBⁱ	60608 60609 [Q15485-2]

PTM databases

iPTMnetⁱ	Q15485

iPTMnetⁱ

Q15485

Expressionⁱ

Tissue specificityⁱ

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgeeⁱ	ENSG00000160339 Expressed in 88 organ(s), highest expression level in liver
CleanExⁱ	HS_FCN2
Genevisibleⁱ	Q15485 HS

Interactionⁱ

Subunit structureⁱ

Homotrimer (PubMed:17215869). Interacts with elastin. Interacts with MASP1 and MASP2.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LRP1	Q07954	2	EBI-7468784,EBI-1046087
PTX3	P26022	7	EBI-7468784,EBI-11574553

GO - Molecular functionⁱ

calcium-dependent protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12421953
proteoglycan binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8576206

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108514, 3 interactors
IntActⁱ	Q15485, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q15485
STRINGⁱ	9606.ENSP00000291744

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	98 – 100	Combined sources	3
Helixⁱ	105 – 110	Combined sources	6
Beta strandⁱ	115 – 122	Combined sources	8
Beta strandⁱ	124 – 126	Combined sources	3
Beta strandⁱ	128 – 134	Combined sources	7
Helixⁱ	137 – 139	Combined sources	3
Beta strandⁱ	142 – 151	Combined sources	10
Helixⁱ	159 – 164	Combined sources	6
Beta strandⁱ	166 – 168	Combined sources	3
Helixⁱ	177 – 182	Combined sources	6
Beta strandⁱ	185 – 187	Combined sources	3
Beta strandⁱ	191 – 196	Combined sources	6
Beta strandⁱ	198 – 200	Combined sources	3
Beta strandⁱ	202 – 208	Combined sources	7
Beta strandⁱ	210 – 212	Combined sources	3
Turnⁱ	215 – 219	Combined sources	5
Beta strandⁱ	221 – 223	Combined sources	3
Beta strandⁱ	226 – 228	Combined sources	3
Helixⁱ	236 – 238	Combined sources	3
Beta strandⁱ	246 – 248	Combined sources	3
Beta strandⁱ	251 – 255	Combined sources	5
Helixⁱ	258 – 261	Combined sources	4
Beta strandⁱ	263 – 265	Combined sources	3
Beta strandⁱ	268 – 270	Combined sources	3
Beta strandⁱ	272 – 274	Combined sources	3
Beta strandⁱ	285 – 288	Combined sources	4
Beta strandⁱ	290 – 293	Combined sources	4
Turnⁱ	294 – 297	Combined sources	4
Beta strandⁱ	299 – 302	Combined sources	4
Beta strandⁱ	304 – 310	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15485
SMRⁱ	Q15485
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q15485

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	51 – 92	Collagen-likeAdd BLAST		42
Domainⁱ	96 – 313	Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST		218

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	241 – 242	Carbohydrate binding1 Publication		2

Domainⁱ

The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.1 Publication

Sequence similaritiesⁱ

Belongs to the ficolin lectin family.Curated

Keywords - Domainⁱ

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG2579 Eukaryota ENOG410ZYS4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150813
HOGENOMⁱ	HOG000037127
HOVERGENⁱ	HBG001644
InParanoidⁱ	Q15485
KEGG Orthology (KO) More...KOⁱ	K10104
OMAⁱ	GNCAVMY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03M1
PhylomeDBⁱ	Q15485
TreeFamⁱ	TF329953

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00087 FReD, 1 hit
Gene3Dⁱ	3.90.215.10, 1 hit 4.10.530.10, 1 hit
InterProⁱ	View protein in InterPro IPR008160 Collagen IPR036056 Fibrinogen-like_C IPR014716 Fibrinogen_a/b/g_C_1 IPR014715 Fibrinogen_a/b/g_C_2 IPR002181 Fibrinogen_a/b/g_C_dom IPR020837 Fibrinogen_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01391 Collagen, 1 hit PF00147 Fibrinogen_C, 1 hit
SMARTⁱ	View protein in SMART SM00186 FBG, 1 hit
SUPFAMⁱ	SSF56496 SSF56496, 1 hit
PROSITEⁱ	View protein in PROSITE PS00514 FIBRINOGEN_C_1, 1 hit PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q15485-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELDRAVGVL GAATLLLSFL GMAWALQAAD TCPEVKMVGL EGSDKLTILR 
        60         70         80         90        100
GCPGLPGAPG PKGEAGTNGK RGERGPPGPP GKAGPPGPNG APGEPQPCLT 
       110        120        130        140        150
GPRTCKDLLD RGHFLSGWHT IYLPDCRPLT VLCDMDTDGG GWTVFQRRVD 
       160        170        180        190        200
GSVDFYRDWA TYKQGFGSRL GEFWLGNDNI HALTAQGTSE LRVDLVDFED 
       210        220        230        240        250
NYQFAKYRSF KVADEAEKYN LVLGAFVEGS AGDSLTFHNN QSFSTKDQDN 
       260        270        280        290        300
DLNTGNCAVM FQGAWWYKNC HVSNLNGRYL RGTHGSFANG INWKSGKGYN 
       310 
YSYKVSEMKV RPA

Length:313

Mass (Da):34,001

Last modified:January 15, 2008 - v2

Checksum:ⁱD363029846CCB3C9

GO

Isoform 2 (identifier: Q15485-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
34-71: Missing.

« Hide

        10         20         30         40         50
MELDRAVGVL GAATLLLSFL GMAWALQAAD TCPGERGPPG PPGKAGPPGP 
        60         70         80         90        100
NGAPGEPQPC LTGPRTCKDL LDRGHFLSGW HTIYLPDCRP LTVLCDMDTD 
       110        120        130        140        150
GGGWTVFQRR VDGSVDFYRD WATYKQGFGS RLGEFWLGND NIHALTAQGT 
       160        170        180        190        200
SELRVDLVDF EDNYQFAKYR SFKVADEAEK YNLVLGAFVE GSAGDSLTFH 
       210        220        230        240        250
NNQSFSTKDQ DNDLNTGNCA VMFQGAWWYK NCHVSNLNGR YLRGTHGSFA 
       260        270 
NGINWKSGKG YNYSYKVSEM KVRPA

Note: No experimental confirmation available.

Show »

Length:275

Mass (Da):30,228

Checksum:ⁱ033A008F64CFA4C0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	61	P → D in BAA08352 (PubMed:8884275).Curated	1
Sequence conflictⁱ	61	P → D in ABB01005 (PubMed:8576206).Curated	1
Sequence conflictⁱ	98	C → A AA sequence (PubMed:8586615).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036342	80	P → L in a colorectal cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_049072	113	H → Y1 PublicationCorresponds to variant dbSNP:rs17549179Ensembl.	1
Natural variantⁱVAR_049073	117	G → S. Corresponds to variant dbSNP:rs12684476Ensembl.	1
Natural variantⁱVAR_049074	236	T → M. Corresponds to variant dbSNP:rs17549193Ensembl.	1
Natural variantⁱVAR_049075	258	A → S. Corresponds to variant dbSNP:rs7851696Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_030027	34 – 71	Missing in isoform 2. CuratedAdd BLAST		38

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D63160 Genomic DNA Translation: BAA09636.1 D49353 mRNA Translation: BAA08352.1 DQ217935 Genomic DNA Translation: ABB01005.1 AK290843 mRNA Translation: BAF83532.1 AL603650 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88133.1 CH471090 Genomic DNA Translation: EAW88135.1 BC069572 mRNA Translation: AAH69572.1 BC069825 mRNA Translation: AAH69825.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6983.1 [Q15485-1]
PIRⁱ	PH0263 S68005
NCBI Reference Sequences More...RefSeqⁱ	NP_004099.2, NM_004108.2 [Q15485-1] NP_056652.1, NM_015837.2 [Q15485-2]
UniGeneⁱ	Hs.54517

Genome annotation databases

Ensemblⁱ	ENST00000291744; ENSP00000291744; ENSG00000160339 [Q15485-1] ENST00000350339; ENSP00000291741; ENSG00000160339 [Q15485-2]
GeneIDⁱ	2220
KEGGⁱ	hsa:2220
UCSC genome browser More...UCSCⁱ	uc004cfg.1 human [Q15485-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15485	Uncharacterized protein		PANPA		319	UniRef90_Q15485
Uncharacterized protein		PANTR		313
Ficolin 2		GORGO		313
Uncharacterized protein		NOMLE		313
UPI00052E48EA		HUMAN		217
+7

Protein	Similar proteins		Species	Score	Length	Source
Q15485	Ficolin-1		RAT		335	UniRef50_Q15485
Ficolin-1		MOUSE		334
Uncharacterized protein		PANPA		319
Uncharacterized protein		NOMLE		313
Ficolin 2		GORGO		313
+85
Q15485-2	Uncharacterized protein		XENLA		289	UniRef50_Q15485-2
Ficolin 2		XENTR		332
Uncharacterized protein		LEPOC		300
Uncharacterized protein		NOMLE		275
Uncharacterized protein		SAIBB		275
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D63160 Genomic DNA Translation: BAA09636.1 D49353 mRNA Translation: BAA08352.1 DQ217935 Genomic DNA Translation: ABB01005.1 AK290843 mRNA Translation: BAF83532.1 AL603650 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88133.1 CH471090 Genomic DNA Translation: EAW88135.1 BC069572 mRNA Translation: AAH69572.1 BC069825 mRNA Translation: AAH69825.1
CCDSⁱ	CCDS6983.1 [Q15485-1]
PIRⁱ	PH0263 S68005
RefSeqⁱ	NP_004099.2, NM_004108.2 [Q15485-1] NP_056652.1, NM_015837.2 [Q15485-2]
UniGeneⁱ	Hs.54517

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2J0G	X-ray	2.85	A/B/C/D/E/F	97-313	[»]
	2J0H	X-ray	2.85	A/B/C/D/E/F	97-313	[»]
	2J0Y	X-ray	2.35	A/B/C/D/E/F	97-313	[»]
	2J1G	X-ray	1.95	A/B/C/D/E/F	97-313	[»]
	2J2P	X-ray	2.80	A/B/C/D/E/F	97-313	[»]
	2J3F	X-ray	2.80	A/B/C/D/E/F	95-313	[»]
	2J3G	X-ray	2.50	A/B/C/D/E/F	97-313	[»]
	2J3O	X-ray	2.65	A/B/C/D/E/F	95-313	[»]
	2J3U	X-ray	2.15	A/B/C/D/E/F	97-313	[»]
	2J61	X-ray	2.70	A/B	97-313	[»]
	4NYT	X-ray	2.25	A/B/C	97-313	[»]
	4R9J	X-ray	2.10	A/B/G	97-313	[»]
	4R9T	X-ray	2.25	A/B/C	97-313	[»]
ProteinModelPortalⁱ	Q15485
SMRⁱ	Q15485
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108514, 3 interactors
IntActⁱ	Q15485, 5 interactors
MINTⁱ	Q15485
STRINGⁱ	9606.ENSP00000291744

Protein family/group databases

UniLectinⁱ	Q15485

UniLectinⁱ

Q15485

PTM databases

iPTMnetⁱ	Q15485

iPTMnetⁱ

Q15485

Polymorphism and mutation databases

BioMutaⁱ	FCN2
DMDMⁱ	166214934

Proteomic databases

MaxQBⁱ	Q15485
PaxDbⁱ	Q15485
PeptideAtlasⁱ	Q15485
PRIDEⁱ	Q15485
ProteomicsDBⁱ	60608 60609 [Q15485-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000291744; ENSP00000291744; ENSG00000160339 [Q15485-1] ENST00000350339; ENSP00000291741; ENSG00000160339 [Q15485-2]
GeneIDⁱ	2220
KEGGⁱ	hsa:2220
UCSCⁱ	uc004cfg.1 human [Q15485-1]

Organism-specific databases

CTDⁱ	2220
DisGeNETⁱ	2220
EuPathDBⁱ	HostDB:ENSG00000160339.15
GeneCardsⁱ	FCN2
HGNCⁱ	HGNC:3624 FCN2
MIMⁱ	601624 gene
neXtProtⁱ	NX_Q15485
OpenTargetsⁱ	ENSG00000160339
PharmGKBⁱ	PA28070
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2579 Eukaryota ENOG410ZYS4 LUCA
GeneTreeⁱ	ENSGT00930000150813
HOGENOMⁱ	HOG000037127
HOVERGENⁱ	HBG001644
InParanoidⁱ	Q15485
KOⁱ	K10104
OMAⁱ	GNCAVMY
OrthoDBⁱ	EOG091G03M1
PhylomeDBⁱ	Q15485
TreeFamⁱ	TF329953

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166662 Lectin pathway of complement activation R-HSA-166663 Initial triggering of complement R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface

Reactomeⁱ

R-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement
R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface

Miscellaneous databases

EvolutionaryTraceⁱ	Q15485
GeneWikiⁱ	FCN2
GenomeRNAiⁱ	2220
Protein Ontology More...PROⁱ	PR:Q15485
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160339 Expressed in 88 organ(s), highest expression level in liver
CleanExⁱ	HS_FCN2
Genevisibleⁱ	Q15485 HS

Family and domain databases

CDDⁱ	cd00087 FReD, 1 hit
Gene3Dⁱ	3.90.215.10, 1 hit 4.10.530.10, 1 hit
InterProⁱ	View protein in InterPro IPR008160 Collagen IPR036056 Fibrinogen-like_C IPR014716 Fibrinogen_a/b/g_C_1 IPR014715 Fibrinogen_a/b/g_C_2 IPR002181 Fibrinogen_a/b/g_C_dom IPR020837 Fibrinogen_CS
Pfamⁱ	View protein in Pfam PF01391 Collagen, 1 hit PF00147 Fibrinogen_C, 1 hit
SMARTⁱ	View protein in SMART SM00186 FBG, 1 hit
SUPFAMⁱ	SSF56496 SSF56496, 1 hit
PROSITEⁱ	View protein in PROSITE PS00514 FIBRINOGEN_C_1, 1 hit PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FCN2_HUMAN
Accessionⁱ	Q15485Primary (citable) accession number: Q15485 Secondary accession number(s): A6NFG7 , A8K478, Q6IS69, Q7M4P4, Q9UC57
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	January 15, 2008
	Last modified:	November 7, 2018
	This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

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Supporting data

UniProtKB - Q15485 (FCN2_HUMAN)

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Ficolin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ