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Protein

Ficolin-2

Gene

FCN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi249CalciumCombined sources1 Publication1
Metal bindingi251CalciumCombined sources1 Publication1
Metal bindingi253Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi255Calcium; via carbonyl oxygenCombined sources1 Publication1

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • calcium-dependent protein binding Source: UniProtKB
  • mannan binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • proteoglycan binding Source: UniProtKB
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

Keywordsi

Biological processComplement activation lectin pathway, Immunity, Innate immunity
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement
R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface

Protein family/group databases

UniLectiniQ15485

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-2
Alternative name(s):
37 kDa elastin-binding protein
Collagen/fibrinogen domain-containing protein 2
EBP-37
Ficolin-B
Ficolin-beta
Hucolin
L-ficolin
Serum lectin p35
Gene namesi
Name:FCN2
Synonyms:FCNL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000160339.15
HGNCiHGNC:3624 FCN2
MIMi601624 gene
neXtProtiNX_Q15485

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2220
OpenTargetsiENSG00000160339
PharmGKBiPA28070

Polymorphism and mutation databases

BioMutaiFCN2
DMDMi166214934

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000913926 – 313Ficolin-2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77Hydroxyproline1 Publication1
Modified residuei80Hydroxyproline1 Publication1
Modified residuei86Hydroxyproline1 Publication1
Disulfide bondi98 ↔ 126By similarity
Disulfide bondi105 ↔ 133Combined sources1 Publication
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
Disulfide bondi257 ↔ 270Combined sources1 Publication
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ15485
PaxDbiQ15485
PeptideAtlasiQ15485
PRIDEiQ15485
ProteomicsDBi60608
60609 [Q15485-2]

PTM databases

iPTMnetiQ15485

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSG00000160339 Expressed in 88 organ(s), highest expression level in liver
CleanExiHS_FCN2
GenevisibleiQ15485 HS

Interactioni

Subunit structurei

Homotrimer (PubMed:17215869). Interacts with elastin. Interacts with MASP1 and MASP2.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108514, 3 interactors
IntActiQ15485, 5 interactors
MINTiQ15485
STRINGi9606.ENSP00000291744

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15485
SMRiQ15485
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15485

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 92Collagen-likeAdd BLAST42
Domaini96 – 313Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST218

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni241 – 242Carbohydrate binding1 Publication2

Domaini

The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.1 Publication

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150813
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiQ15485
KOiK10104
OMAiGNCAVMY
OrthoDBiEOG091G03M1
PhylomeDBiQ15485
TreeFamiTF329953

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q15485-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELDRAVGVL GAATLLLSFL GMAWALQAAD TCPEVKMVGL EGSDKLTILR
60 70 80 90 100
GCPGLPGAPG PKGEAGTNGK RGERGPPGPP GKAGPPGPNG APGEPQPCLT
110 120 130 140 150
GPRTCKDLLD RGHFLSGWHT IYLPDCRPLT VLCDMDTDGG GWTVFQRRVD
160 170 180 190 200
GSVDFYRDWA TYKQGFGSRL GEFWLGNDNI HALTAQGTSE LRVDLVDFED
210 220 230 240 250
NYQFAKYRSF KVADEAEKYN LVLGAFVEGS AGDSLTFHNN QSFSTKDQDN
260 270 280 290 300
DLNTGNCAVM FQGAWWYKNC HVSNLNGRYL RGTHGSFANG INWKSGKGYN
310
YSYKVSEMKV RPA
Length:313
Mass (Da):34,001
Last modified:January 15, 2008 - v2
Checksum:iD363029846CCB3C9
GO
Isoform 2 (identifier: Q15485-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-71: Missing.

Note: No experimental confirmation available.
Show »
Length:275
Mass (Da):30,228
Checksum:i033A008F64CFA4C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61P → D in BAA08352 (PubMed:8884275).Curated1
Sequence conflicti61P → D in ABB01005 (PubMed:8576206).Curated1
Sequence conflicti98C → A AA sequence (PubMed:8586615).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03634280P → L in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_049072113H → Y1 PublicationCorresponds to variant dbSNP:rs17549179Ensembl.1
Natural variantiVAR_049073117G → S. Corresponds to variant dbSNP:rs12684476Ensembl.1
Natural variantiVAR_049074236T → M. Corresponds to variant dbSNP:rs17549193Ensembl.1
Natural variantiVAR_049075258A → S. Corresponds to variant dbSNP:rs7851696Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03002734 – 71Missing in isoform 2. CuratedAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63160 Genomic DNA Translation: BAA09636.1
D49353 mRNA Translation: BAA08352.1
DQ217935 Genomic DNA Translation: ABB01005.1
AK290843 mRNA Translation: BAF83532.1
AL603650 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88133.1
CH471090 Genomic DNA Translation: EAW88135.1
BC069572 mRNA Translation: AAH69572.1
BC069825 mRNA Translation: AAH69825.1
CCDSiCCDS6983.1 [Q15485-1]
PIRiPH0263
S68005
RefSeqiNP_004099.2, NM_004108.2 [Q15485-1]
NP_056652.1, NM_015837.2 [Q15485-2]
UniGeneiHs.54517

Genome annotation databases

EnsembliENST00000291744; ENSP00000291744; ENSG00000160339 [Q15485-1]
ENST00000350339; ENSP00000291741; ENSG00000160339 [Q15485-2]
GeneIDi2220
KEGGihsa:2220
UCSCiuc004cfg.1 human [Q15485-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63160 Genomic DNA Translation: BAA09636.1
D49353 mRNA Translation: BAA08352.1
DQ217935 Genomic DNA Translation: ABB01005.1
AK290843 mRNA Translation: BAF83532.1
AL603650 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88133.1
CH471090 Genomic DNA Translation: EAW88135.1
BC069572 mRNA Translation: AAH69572.1
BC069825 mRNA Translation: AAH69825.1
CCDSiCCDS6983.1 [Q15485-1]
PIRiPH0263
S68005
RefSeqiNP_004099.2, NM_004108.2 [Q15485-1]
NP_056652.1, NM_015837.2 [Q15485-2]
UniGeneiHs.54517

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J0GX-ray2.85A/B/C/D/E/F97-313[»]
2J0HX-ray2.85A/B/C/D/E/F97-313[»]
2J0YX-ray2.35A/B/C/D/E/F97-313[»]
2J1GX-ray1.95A/B/C/D/E/F97-313[»]
2J2PX-ray2.80A/B/C/D/E/F97-313[»]
2J3FX-ray2.80A/B/C/D/E/F95-313[»]
2J3GX-ray2.50A/B/C/D/E/F97-313[»]
2J3OX-ray2.65A/B/C/D/E/F95-313[»]
2J3UX-ray2.15A/B/C/D/E/F97-313[»]
2J61X-ray2.70A/B97-313[»]
4NYTX-ray2.25A/B/C97-313[»]
4R9JX-ray2.10A/B/G97-313[»]
4R9TX-ray2.25A/B/C97-313[»]
ProteinModelPortaliQ15485
SMRiQ15485
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108514, 3 interactors
IntActiQ15485, 5 interactors
MINTiQ15485
STRINGi9606.ENSP00000291744

Protein family/group databases

UniLectiniQ15485

PTM databases

iPTMnetiQ15485

Polymorphism and mutation databases

BioMutaiFCN2
DMDMi166214934

Proteomic databases

MaxQBiQ15485
PaxDbiQ15485
PeptideAtlasiQ15485
PRIDEiQ15485
ProteomicsDBi60608
60609 [Q15485-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291744; ENSP00000291744; ENSG00000160339 [Q15485-1]
ENST00000350339; ENSP00000291741; ENSG00000160339 [Q15485-2]
GeneIDi2220
KEGGihsa:2220
UCSCiuc004cfg.1 human [Q15485-1]

Organism-specific databases

CTDi2220
DisGeNETi2220
EuPathDBiHostDB:ENSG00000160339.15
GeneCardsiFCN2
HGNCiHGNC:3624 FCN2
MIMi601624 gene
neXtProtiNX_Q15485
OpenTargetsiENSG00000160339
PharmGKBiPA28070
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150813
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiQ15485
KOiK10104
OMAiGNCAVMY
OrthoDBiEOG091G03M1
PhylomeDBiQ15485
TreeFamiTF329953

Enzyme and pathway databases

ReactomeiR-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement
R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface

Miscellaneous databases

EvolutionaryTraceiQ15485
GeneWikiiFCN2
GenomeRNAii2220
PROiPR:Q15485
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160339 Expressed in 88 organ(s), highest expression level in liver
CleanExiHS_FCN2
GenevisibleiQ15485 HS

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCN2_HUMAN
AccessioniPrimary (citable) accession number: Q15485
Secondary accession number(s): A6NFG7
, A8K478, Q6IS69, Q7M4P4, Q9UC57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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