UniProtKB - Q15485 (FCN2_HUMAN)
Protein
Ficolin-2
Gene
FCN2
Organism
Homo sapiens (Human)
Status
Functioni
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 249 | CalciumCombined sources1 Publication | 1 | |
Metal bindingi | 251 | CalciumCombined sources1 Publication | 1 | |
Metal bindingi | 253 | Calcium; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 255 | Calcium; via carbonyl oxygenCombined sources1 Publication | 1 |
GO - Molecular functioni
- antigen binding Source: UniProtKB
- calcium-dependent protein binding Source: UniProtKB
- carbohydrate derivative binding Source: GO_Central
- mannan binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- proteoglycan binding Source: UniProtKB
- signaling receptor binding Source: GO_Central
GO - Biological processi
- complement activation Source: Reactome
- complement activation, lectin pathway Source: UniProtKB
- defense response to Gram-negative bacterium Source: UniProtKB
- defense response to Gram-positive bacterium Source: UniProtKB
- opsonization Source: UniProtKB
- recognition of apoptotic cell Source: UniProtKB
Keywordsi
Biological process | Complement activation lectin pathway, Immunity, Innate immunity |
Ligand | Calcium, Lectin, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q15485 |
Reactomei | R-HSA-166662, Lectin pathway of complement activation R-HSA-166663, Initial triggering of complement R-HSA-2855086, Ficolins bind to repetitive carbohydrate structures on the target cell surface |
Protein family/group databases
UniLectini | Q15485 |
Names & Taxonomyi
Protein namesi | Recommended name: Ficolin-2Alternative name(s): 37 kDa elastin-binding protein Collagen/fibrinogen domain-containing protein 2 EBP-37 Ficolin-B Ficolin-beta Hucolin L-ficolin Serum lectin p35 |
Gene namesi | Name:FCN2 Synonyms:FCNL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3624, FCN2 |
MIMi | 601624, gene |
neXtProti | NX_Q15485 |
VEuPathDBi | HostDB:ENSG00000160339.15 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- collagen trimer Source: UniProtKB-KW
- collagen-containing extracellular matrix Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 2220 |
OpenTargetsi | ENSG00000160339 |
PharmGKBi | PA28070 |
Miscellaneous databases
Pharosi | Q15485, Tbio |
Genetic variation databases
BioMutai | FCN2 |
DMDMi | 166214934 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000009139 | 26 – 313 | Ficolin-2Add BLAST | 288 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 77 | Hydroxyproline1 Publication | 1 | |
Modified residuei | 80 | Hydroxyproline1 Publication | 1 | |
Modified residuei | 86 | Hydroxyproline1 Publication | 1 | |
Disulfide bondi | 98 ↔ 126 | By similarity | ||
Disulfide bondi | 105 ↔ 133 | Combined sources1 Publication | ||
Glycosylationi | 240 | N-linked (GlcNAc...) asparagineSequence analysis1 Publication | 1 | |
Disulfide bondi | 257 ↔ 270 | Combined sources1 Publication | ||
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, HydroxylationProteomic databases
jPOSTi | Q15485 |
MassIVEi | Q15485 |
MaxQBi | Q15485 |
PaxDbi | Q15485 |
PeptideAtlasi | Q15485 |
PRIDEi | Q15485 |
ProteomicsDBi | 60608 [Q15485-1] 60609 [Q15485-2] |
PTM databases
GlyGeni | Q15485, 2 sites |
iPTMneti | Q15485 |
Expressioni
Tissue specificityi
Expressed by the liver and secreted in plasma.
Gene expression databases
Bgeei | ENSG00000160339, Expressed in liver and 107 other tissues |
Genevisiblei | Q15485, HS |
Organism-specific databases
HPAi | ENSG00000160339, Tissue enriched (liver) |
Interactioni
Subunit structurei
Homotrimer (PubMed:17215869).
Interacts with elastin.
Interacts with MASP1 and MASP2.
Interacts with CR1.
4 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- proteoglycan binding Source: UniProtKB
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 108514, 3 interactors |
ComplexPortali | CPX-6178, FCN2-MASP1 lectin-protease complex CPX-6238, FCN2-MASP2 lectin-protease complex |
IntActi | Q15485, 8 interactors |
MINTi | Q15485 |
STRINGi | 9606.ENSP00000291744 |
Miscellaneous databases
RNActi | Q15485, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q15485 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15485 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 92 | Collagen-likeAdd BLAST | 42 | |
Domaini | 96 – 313 | Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST | 218 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 241 – 242 | Carbohydrate binding1 Publication | 2 |
Domaini
The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.1 Publication
Sequence similaritiesi
Belongs to the ficolin lectin family.Curated
Keywords - Domaini
Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000164320 |
HOGENOMi | CLU_038628_3_3_1 |
InParanoidi | Q15485 |
OMAi | WYKNCHV |
OrthoDBi | 1035379at2759 |
PhylomeDBi | Q15485 |
TreeFami | TF329953 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit 4.10.530.10, 1 hit |
InterProi | View protein in InterPro IPR008160, Collagen IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR014715, Fibrinogen_a/b/g_C_2 IPR002181, Fibrinogen_a/b/g_C_dom IPR020837, Fibrinogen_CS |
Pfami | View protein in Pfam PF01391, Collagen, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q15485-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELDRAVGVL GAATLLLSFL GMAWALQAAD TCPEVKMVGL EGSDKLTILR
60 70 80 90 100
GCPGLPGAPG PKGEAGTNGK RGERGPPGPP GKAGPPGPNG APGEPQPCLT
110 120 130 140 150
GPRTCKDLLD RGHFLSGWHT IYLPDCRPLT VLCDMDTDGG GWTVFQRRVD
160 170 180 190 200
GSVDFYRDWA TYKQGFGSRL GEFWLGNDNI HALTAQGTSE LRVDLVDFED
210 220 230 240 250
NYQFAKYRSF KVADEAEKYN LVLGAFVEGS AGDSLTFHNN QSFSTKDQDN
260 270 280 290 300
DLNTGNCAVM FQGAWWYKNC HVSNLNGRYL RGTHGSFANG INWKSGKGYN
310
YSYKVSEMKV RPA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | P → D in BAA08352 (PubMed:8884275).Curated | 1 | |
Sequence conflicti | 61 | P → D in ABB01005 (PubMed:8576206).Curated | 1 | |
Sequence conflicti | 98 | C → A AA sequence (PubMed:8586615).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036342 | 80 | P → L in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_049072 | 113 | H → Y1 PublicationCorresponds to variant dbSNP:rs17549179Ensembl. | 1 | |
Natural variantiVAR_049073 | 117 | G → S. Corresponds to variant dbSNP:rs12684476Ensembl. | 1 | |
Natural variantiVAR_049074 | 236 | T → M. Corresponds to variant dbSNP:rs17549193Ensembl. | 1 | |
Natural variantiVAR_049075 | 258 | A → S. Corresponds to variant dbSNP:rs7851696Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030027 | 34 – 71 | Missing in isoform 2. CuratedAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D63160 Genomic DNA Translation: BAA09636.1 D49353 mRNA Translation: BAA08352.1 DQ217935 Genomic DNA Translation: ABB01005.1 AK290843 mRNA Translation: BAF83532.1 AL603650 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88133.1 CH471090 Genomic DNA Translation: EAW88135.1 BC069572 mRNA Translation: AAH69572.1 BC069825 mRNA Translation: AAH69825.1 |
CCDSi | CCDS6983.1 [Q15485-1] |
PIRi | PH0263 S68005 |
RefSeqi | NP_004099.2, NM_004108.2 [Q15485-1] NP_056652.1, NM_015837.2 [Q15485-2] |
Genome annotation databases
Ensembli | ENST00000291744; ENSP00000291744; ENSG00000160339 [Q15485-1] ENST00000350339; ENSP00000291741; ENSG00000160339 [Q15485-2] |
GeneIDi | 2220 |
KEGGi | hsa:2220 |
UCSCi | uc004cfg.1, human [Q15485-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D63160 Genomic DNA Translation: BAA09636.1 D49353 mRNA Translation: BAA08352.1 DQ217935 Genomic DNA Translation: ABB01005.1 AK290843 mRNA Translation: BAF83532.1 AL603650 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88133.1 CH471090 Genomic DNA Translation: EAW88135.1 BC069572 mRNA Translation: AAH69572.1 BC069825 mRNA Translation: AAH69825.1 |
CCDSi | CCDS6983.1 [Q15485-1] |
PIRi | PH0263 S68005 |
RefSeqi | NP_004099.2, NM_004108.2 [Q15485-1] NP_056652.1, NM_015837.2 [Q15485-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2J0G | X-ray | 2.85 | A/B/C/D/E/F | 97-313 | [»] | |
2J0H | X-ray | 2.85 | A/B/C/D/E/F | 97-313 | [»] | |
2J0Y | X-ray | 2.35 | A/B/C/D/E/F | 97-313 | [»] | |
2J1G | X-ray | 1.95 | A/B/C/D/E/F | 97-313 | [»] | |
2J2P | X-ray | 2.80 | A/B/C/D/E/F | 97-313 | [»] | |
2J3F | X-ray | 2.80 | A/B/C/D/E/F | 95-313 | [»] | |
2J3G | X-ray | 2.50 | A/B/C/D/E/F | 97-313 | [»] | |
2J3O | X-ray | 2.65 | A/B/C/D/E/F | 95-313 | [»] | |
2J3U | X-ray | 2.15 | A/B/C/D/E/F | 97-313 | [»] | |
2J61 | X-ray | 2.70 | A/B | 97-313 | [»] | |
4NYT | X-ray | 2.25 | A/B/C | 97-313 | [»] | |
4R9J | X-ray | 2.10 | A/B/G | 97-313 | [»] | |
4R9T | X-ray | 2.25 | A/B/C | 97-313 | [»] | |
SMRi | Q15485 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108514, 3 interactors |
ComplexPortali | CPX-6178, FCN2-MASP1 lectin-protease complex CPX-6238, FCN2-MASP2 lectin-protease complex |
IntActi | Q15485, 8 interactors |
MINTi | Q15485 |
STRINGi | 9606.ENSP00000291744 |
Protein family/group databases
UniLectini | Q15485 |
PTM databases
GlyGeni | Q15485, 2 sites |
iPTMneti | Q15485 |
Genetic variation databases
BioMutai | FCN2 |
DMDMi | 166214934 |
Proteomic databases
jPOSTi | Q15485 |
MassIVEi | Q15485 |
MaxQBi | Q15485 |
PaxDbi | Q15485 |
PeptideAtlasi | Q15485 |
PRIDEi | Q15485 |
ProteomicsDBi | 60608 [Q15485-1] 60609 [Q15485-2] |
Protocols and materials databases
Antibodypediai | 32017, 223 antibodies |
Genome annotation databases
Ensembli | ENST00000291744; ENSP00000291744; ENSG00000160339 [Q15485-1] ENST00000350339; ENSP00000291741; ENSG00000160339 [Q15485-2] |
GeneIDi | 2220 |
KEGGi | hsa:2220 |
UCSCi | uc004cfg.1, human [Q15485-1] |
Organism-specific databases
CTDi | 2220 |
DisGeNETi | 2220 |
GeneCardsi | FCN2 |
HGNCi | HGNC:3624, FCN2 |
HPAi | ENSG00000160339, Tissue enriched (liver) |
MIMi | 601624, gene |
neXtProti | NX_Q15485 |
OpenTargetsi | ENSG00000160339 |
PharmGKBi | PA28070 |
VEuPathDBi | HostDB:ENSG00000160339.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000164320 |
HOGENOMi | CLU_038628_3_3_1 |
InParanoidi | Q15485 |
OMAi | WYKNCHV |
OrthoDBi | 1035379at2759 |
PhylomeDBi | Q15485 |
TreeFami | TF329953 |
Enzyme and pathway databases
PathwayCommonsi | Q15485 |
Reactomei | R-HSA-166662, Lectin pathway of complement activation R-HSA-166663, Initial triggering of complement R-HSA-2855086, Ficolins bind to repetitive carbohydrate structures on the target cell surface |
Miscellaneous databases
BioGRID-ORCSi | 2220, 7 hits in 977 CRISPR screens |
EvolutionaryTracei | Q15485 |
GeneWikii | FCN2 |
GenomeRNAii | 2220 |
Pharosi | Q15485, Tbio |
PROi | PR:Q15485 |
RNActi | Q15485, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160339, Expressed in liver and 107 other tissues |
Genevisiblei | Q15485, HS |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit 4.10.530.10, 1 hit |
InterProi | View protein in InterPro IPR008160, Collagen IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR014715, Fibrinogen_a/b/g_C_2 IPR002181, Fibrinogen_a/b/g_C_dom IPR020837, Fibrinogen_CS |
Pfami | View protein in Pfam PF01391, Collagen, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FCN2_HUMAN | |
Accessioni | Q15485Primary (citable) accession number: Q15485 Secondary accession number(s): A6NFG7 Q9UC57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | January 15, 2008 | |
Last modified: | April 7, 2021 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families