Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Helicase SKI2W

Gene

SKIV2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi332 – 339ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q15477 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Helicase SKI2W (EC:3.6.4.-)
Short name:
Ski2
Alternative name(s):
Helicase-like protein
Short name:
HLP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SKIV2L
Synonyms:DDX13, SKI2W, SKIV2, W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204351.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10898 SKIV2L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600478 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15477

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Trichohepatoenteric syndrome 2 (THES2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by intrauterine growth retardation, severe diarrhea in infancy requiring total parenteral nutrition, facial dysmorphism, immunodeficiency, and hair abnormalities, mostly trichorrhexis nodosa. Hepatic involvement contributes to the poor prognosis of affected patients.
See also OMIM:614602
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067721341V → G in THES2. 1 PublicationCorresponds to variant dbSNP:rs281875237EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6499

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SKIV2L

MalaCards human disease database

More...
MalaCardsi
SKIV2L
MIMi614602 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000204351

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
84064 Syndromic diarrhea

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35798

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SKIV2L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104288

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001020911 – 1246Helicase SKI2WAdd BLAST1246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei245PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15477

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15477

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15477

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15477

PeptideAtlas

More...
PeptideAtlasi
Q15477

PRoteomics IDEntifications database

More...
PRIDEi
Q15477

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60607

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15477

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15477

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204351 Expressed in 225 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_SKIV2L

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15477 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15477 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051959
HPA054419

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SKI complex which consists of WDR61, SKIV2L and TTC37.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112390, 44 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q15477

Protein interaction database and analysis system

More...
IntActi
Q15477, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364543

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15477

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15477

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini319 – 475Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST157
Domaini585 – 755Helicase C-terminalPROSITE-ProRule annotationAdd BLAST171

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi423 – 426DEVH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. SKI2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0948 Eukaryota
COG4581 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158255

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000163048

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG060025

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15477

KEGG Orthology (KO)

More...
KOi
K12599

Identification of Orthologs from Complete Genome Data

More...
OMAi
VIIMLPD

Database of Orthologous Groups

More...
OrthoDBi
176060at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15477

TreeFam database of animal gene trees

More...
TreeFami
TF314438

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR025696 rRNA_proc-arch_dom
IPR016438 Ski2-like
IPR012961 Ski2_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF08148 DSHCT, 1 hit
PF00271 Helicase_C, 1 hit
PF13234 rRNA_proc-arch, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005198 Antiviral_helicase_SKI2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM01142 DSHCT, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q15477-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMETERLVLP PPDPLDLPLR AVELGCTGHW ELLNLPGAPE SSLPHGLPPC
60 70 80 90 100
APDLQQEAEQ LFLSSPAWLP LHGVEHSARK WQRKTDPWSL LAVLGAPVPS
110 120 130 140 150
DLQAQRHPTT GQILGYKEVL LENTNLSATT SLSLRRPPGP ASQSLWGNPT
160 170 180 190 200
QYPFWPGGMD EPTITDLNTR EEAEEEIDFE KDLLTIPPGF KKGMDFAPKD
210 220 230 240 250
CPTPAPGLLS LSCMLEPLDL GGGDEDENEA VGQPGGPRGD TVSASPCSAP
260 270 280 290 300
LARASSLEDL VLKEASTAVS TPEAPEPPSQ EQWAIPVDAT SPVGDFYRLI
310 320 330 340 350
PQPAFQWAFE PDVFQKQAIL HLERHDSVFV AAHTSAGKTV VAEYAIALAQ
360 370 380 390 400
KHMTRTIYTS PIKALSNQKF RDFRNTFGDV GLLTGDVQLH PEASCLIMTT
410 420 430 440 450
EILRSMLYSG SDVIRDLEWV IFDEVHYIND VERGVVWEEV LIMLPDHVSI
460 470 480 490 500
ILLSATVPNA LEFADWIGRL KRRQIYVIST VTRPVPLEHY LFTGNSSKTQ
510 520 530 540 550
GELFLLLDSR GAFHTKGYYA AVEAKKERMS KHAQTFGAKQ PTHQGGPAQD
560 570 580 590 600
RGVYLSLLAS LRTRAQLPVV VFTFSRGRCD EQASGLTSLD LTTSSEKSEI
610 620 630 640 650
HLFLQRCLAR LRGSDRQLPQ VLHMSELLNR GLGVHHSGIL PILKEIVEML
660 670 680 690 700
FSRGLVKVLF ATETFAMGVN MPARTVVFDS MRKHDGSTFR DLLPGEYVQM
710 720 730 740 750
AGRAGRRGLD PTGTVILLCK GRVPEMADLH RMMMGKPSQL QSQFRLTYTM
760 770 780 790 800
ILNLLRVDAL RVEDMMKRSF SEFPSRKDSK AHEQALAELT KRLGALEEPD
810 820 830 840 850
MTGQLVDLPE YYSWGEELTE TQHMIQRRIM ESVNGLKSLS AGRVVVVKNQ
860 870 880 890 900
EHHNALGVIL QVSSNSTSRV FTTLVLCDKP LSQDPQDRGP ATAEVPYPDD
910 920 930 940 950
LVGFKLFLPE GPCDHTVVKL QPGDMAAITT KVLRVNGEKI LEDFSKRQQP
960 970 980 990 1000
KFKKDPPLAA VTTAVQELLR LAQAHPAGPP TLDPVNDLQL KDMSVVEGGL
1010 1020 1030 1040 1050
RARKLEELIQ GAQCVHSPRF PAQYLKLRER MQIQKEMERL RFLLSDQSLL
1060 1070 1080 1090 1100
LLPEYHQRVE VLRTLGYVDE AGTVKLAGRV ACAMSSHELL LTELMFDNAL
1110 1120 1130 1140 1150
STLRPEEIAA LLSGLVCQSP GDAGDQLPNT LKQGIERVRA VAKRIGEVQV
1160 1170 1180 1190 1200
ACGLNQTVEE FVGELNFGLV EVVYEWARGM PFSELAGLSG TPEGLVVRCI
1210 1220 1230 1240
QRLAEMCRSL RGAARLVGEP VLGAKMETAA TLLRRDIVFA ASLYTQ
Length:1,246
Mass (Da):137,755
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F00097BA83A4AEC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4E0B4B4E0B4_HUMAN
Helicase SKI2W
SKIV2L
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4L3H7C4L3_HUMAN
Helicase SKI2W
SKIV2L
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5N0H7C5N0_HUMAN
Helicase SKI2W
SKIV2L
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDE8F8WDE8_HUMAN
Helicase SKI2W
SKIV2L
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB52523 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti366S → T in AAB52523 (PubMed:7759100).Curated1
Sequence conflicti623H → Q in CAA88733 (PubMed:7610041).Curated1
Sequence conflicti1052L → F in CAA88733 (PubMed:7610041).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060379151Q → R2 PublicationsCorresponds to variant dbSNP:rs438999EnsemblClinVar.1
Natural variantiVAR_035944183L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_060380214M → L3 PublicationsCorresponds to variant dbSNP:rs437179EnsemblClinVar.1
Natural variantiVAR_055888324R → W. Corresponds to variant dbSNP:rs36038685EnsemblClinVar.1
Natural variantiVAR_067721341V → G in THES2. 1 PublicationCorresponds to variant dbSNP:rs281875237EnsemblClinVar.1
Natural variantiVAR_035945765M → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs557829269Ensembl.1
Natural variantiVAR_055889887D → N. Corresponds to variant dbSNP:rs3911893EnsemblClinVar.1
Natural variantiVAR_055890917V → M1 PublicationCorresponds to variant dbSNP:rs106287EnsemblClinVar.1
Natural variantiVAR_0558911071A → V1 PublicationCorresponds to variant dbSNP:rs449643EnsemblClinVar.1
Natural variantiVAR_0603811153G → R. Corresponds to variant dbSNP:rs2734329Ensembl.1
Natural variantiVAR_0603821238V → G. Corresponds to variant dbSNP:rs2746400Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09877 mRNA Translation: AAB52523.1 Different initiation.
X98378 Genomic DNA Translation: CAA67024.1
Z48796 mRNA Translation: CAA88733.1
AF019413 Genomic DNA Translation: AAB67978.1
AL662849 Genomic DNA No translation available.
AL645922 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4731.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S56752

NCBI Reference Sequences

More...
RefSeqi
NP_008860.4, NM_006929.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.89864

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375394; ENSP00000364543; ENSG00000204351
ENST00000383336; ENSP00000372827; ENSG00000206353
ENST00000412823; ENSP00000400626; ENSG00000232616
ENST00000421789; ENSP00000399530; ENSG00000228896
ENST00000429465; ENSP00000412310; ENSG00000223493
ENST00000448219; ENSP00000394400; ENSG00000225737

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6499

UCSC genome browser

More...
UCSCi
uc003nyn.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09877 mRNA Translation: AAB52523.1 Different initiation.
X98378 Genomic DNA Translation: CAA67024.1
Z48796 mRNA Translation: CAA88733.1
AF019413 Genomic DNA Translation: AAB67978.1
AL662849 Genomic DNA No translation available.
AL645922 Genomic DNA No translation available.
CCDSiCCDS4731.1
PIRiS56752
RefSeqiNP_008860.4, NM_006929.4
UniGeneiHs.89864

3D structure databases

ProteinModelPortaliQ15477
SMRiQ15477
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112390, 44 interactors
CORUMiQ15477
IntActiQ15477, 19 interactors
STRINGi9606.ENSP00000364543

Protein family/group databases

MoonDBiQ15477 Predicted

PTM databases

iPTMnetiQ15477
PhosphoSitePlusiQ15477

Polymorphism and mutation databases

BioMutaiSKIV2L
DMDMi313104288

Proteomic databases

EPDiQ15477
jPOSTiQ15477
MaxQBiQ15477
PaxDbiQ15477
PeptideAtlasiQ15477
PRIDEiQ15477
ProteomicsDBi60607

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6499
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375394; ENSP00000364543; ENSG00000204351
ENST00000383336; ENSP00000372827; ENSG00000206353
ENST00000412823; ENSP00000400626; ENSG00000232616
ENST00000421789; ENSP00000399530; ENSG00000228896
ENST00000429465; ENSP00000412310; ENSG00000223493
ENST00000448219; ENSP00000394400; ENSG00000225737
GeneIDi6499
KEGGihsa:6499
UCSCiuc003nyn.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6499
DisGeNETi6499
EuPathDBiHostDB:ENSG00000204351.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SKIV2L
GeneReviewsiSKIV2L

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0005742
HIX0166115
HIX0166390
HIX0166908
HIX0167165
HIX0167404
HGNCiHGNC:10898 SKIV2L
HPAiHPA051959
HPA054419
MalaCardsiSKIV2L
MIMi600478 gene
614602 phenotype
neXtProtiNX_Q15477
OpenTargetsiENSG00000204351
Orphaneti84064 Syndromic diarrhea
PharmGKBiPA35798

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0948 Eukaryota
COG4581 LUCA
GeneTreeiENSGT00940000158255
HOGENOMiHOG000163048
HOVERGENiHBG060025
InParanoidiQ15477
KOiK12599
OMAiVIIMLPD
OrthoDBi176060at2759
PhylomeDBiQ15477
TreeFamiTF314438

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SKIV2L human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SKIV2L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6499

Protein Ontology

More...
PROi
PR:Q15477

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204351 Expressed in 225 organ(s), highest expression level in right lobe of liver
CleanExiHS_SKIV2L
ExpressionAtlasiQ15477 baseline and differential
GenevisibleiQ15477 HS

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR025696 rRNA_proc-arch_dom
IPR016438 Ski2-like
IPR012961 Ski2_C
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF08148 DSHCT, 1 hit
PF00271 Helicase_C, 1 hit
PF13234 rRNA_proc-arch, 1 hit
PIRSFiPIRSF005198 Antiviral_helicase_SKI2, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM01142 DSHCT, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKIV2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15477
Secondary accession number(s): O15005
, Q12902, Q15476, Q5ST66
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 30, 2010
Last modified: January 16, 2019
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again