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Protein

Nuclear receptor subfamily 0 group B member 2

Gene

NR0B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
SignaLinkiQ15466
SIGNORiQ15466

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 0 group B member 2
Alternative name(s):
Orphan nuclear receptor SHP
Small heterodimer partner
Gene namesi
Name:NR0B2
Synonyms:SHP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000131910.4
HGNCiHGNC:7961 NR0B2
MIMi604630 gene
neXtProtiNX_Q15466

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Obesity (OBESITY)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
See also OMIM:601665

Keywords - Diseasei

Disease mutation, Obesity

Organism-specific databases

DisGeNETi8431
MalaCardsiNR0B2
MIMi601665 phenotype
OpenTargetsiENSG00000131910
PharmGKBiPA31747

Chemistry databases

ChEMBLiCHEMBL5603
GuidetoPHARMACOLOGYi636

Polymorphism and mutation databases

BioMutaiNR0B2
DMDMi9978744

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537521 – 257Nuclear receptor subfamily 0 group B member 2Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54Symmetric dimethylarginineBy similarity1
Modified residuei57Symmetric dimethylarginine; by PRMT5By similarity1

Post-translational modificationi

Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ15466
PeptideAtlasiQ15466
PRIDEiQ15466
ProteomicsDBi60603

PTM databases

iPTMnetiQ15466
PhosphoSitePlusiQ15466

Expressioni

Tissue specificityi

Liver. Low levels of expression were detected in heart and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000131910 Expressed in 75 organ(s), highest expression level in right lobe of liver
CleanExiHS_NR0B2
GenevisibleiQ15466 HS

Interactioni

Subunit structurei

Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114012, 63 interactors
CORUMiQ15466
DIPiDIP-46313N
IntActiQ15466, 24 interactors
MINTiQ15466
STRINGi9606.ENSP00000254227

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15466
SMRiQ15466
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15466

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 257NR LBDPROSITE-ProRule annotationAdd BLAST242

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00390000015719
HOGENOMiHOG000231151
HOVERGENiHBG008136
InParanoidiQ15466
KOiK08563
OMAiCQLPPQD
OrthoDBiEOG091G0FGK
PhylomeDBiQ15466
TreeFamiTF332386

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q15466-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTSQPGACP CQGAASRPAI LYALLSSSLK AVPRPRSRCL CRQHRPVQLC
60 70 80 90 100
APHRTCREAL DVLAKTVAFL RNLPSFWQLP PQDQRRLLQG CWGPLFLLGL
110 120 130 140 150
AQDAVTFEVA EAPVPSILKK ILLEEPSSSG GSGQLPDRPQ PSLAAVQWLQ
160 170 180 190 200
CCLESFWSLE LSPKEYACLK GTILFNPDVP GLQAASHIGH LQQEAHWVLC
210 220 230 240 250
EVLEPWCPAA QGRLTRVLLT ASTLKSIPTS LLGDLFFRPI IGDVDIAGLL

GDMLLLR
Length:257
Mass (Da):28,058
Last modified:December 1, 2000 - v2
Checksum:i14BEE2B3FF46154A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02601557R → W in early-onset obesity; Japanese population; loss of methylation and repressor activity. 2 PublicationsCorresponds to variant dbSNP:rs777291973Ensembl.1
Natural variantiVAR_050584171G → A. Corresponds to variant dbSNP:rs6659176Ensembl.1
Natural variantiVAR_026016189G → E in early-onset obesity; Japanese population; strong decrease of repressor activity. 1 PublicationCorresponds to variant dbSNP:rs202154574Ensembl.1
Natural variantiVAR_026017195A → S in early-onset obesity; Japanese population; slight decrease of repressor activity. 1 PublicationCorresponds to variant dbSNP:rs74315350EnsemblClinVar.1
Natural variantiVAR_026018213R → C in early-onset obesity; Japanese population; loss of repressor activity. 1 PublicationCorresponds to variant dbSNP:rs199976415Ensembl.1
Natural variantiVAR_026019216R → H No effect on repressor activity. 1 PublicationCorresponds to variant dbSNP:rs200475847Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76571 Genomic DNA Translation: AAC41998.1
AB058644 Genomic DNA Translation: BAB68530.1
HQ692833 mRNA Translation: ADZ17344.1
AL356390 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07781.1
BC030207 mRNA Translation: AAH30207.1
CCDSiCCDS291.1
RefSeqiNP_068804.1, NM_021969.2
UniGeneiHs.427055

Genome annotation databases

EnsembliENST00000254227; ENSP00000254227; ENSG00000131910
GeneIDi8431
KEGGihsa:8431
UCSCiuc001bnf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76571 Genomic DNA Translation: AAC41998.1
AB058644 Genomic DNA Translation: BAB68530.1
HQ692833 mRNA Translation: ADZ17344.1
AL356390 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07781.1
BC030207 mRNA Translation: AAH30207.1
CCDSiCCDS291.1
RefSeqiNP_068804.1, NM_021969.2
UniGeneiHs.427055

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YUCX-ray1.90C/D15-28[»]
2Q3YX-ray2.40B18-27[»]
2Z4JX-ray2.60B115-124[»]
4DORX-ray1.90C/D15-28[»]
4ONIX-ray1.80C/D12-30[»]
5UFSX-ray2.12C/D18-27[»]
ProteinModelPortaliQ15466
SMRiQ15466
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114012, 63 interactors
CORUMiQ15466
DIPiDIP-46313N
IntActiQ15466, 24 interactors
MINTiQ15466
STRINGi9606.ENSP00000254227

Chemistry databases

ChEMBLiCHEMBL5603
GuidetoPHARMACOLOGYi636

PTM databases

iPTMnetiQ15466
PhosphoSitePlusiQ15466

Polymorphism and mutation databases

BioMutaiNR0B2
DMDMi9978744

Proteomic databases

PaxDbiQ15466
PeptideAtlasiQ15466
PRIDEiQ15466
ProteomicsDBi60603

Protocols and materials databases

DNASUi8431
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254227; ENSP00000254227; ENSG00000131910
GeneIDi8431
KEGGihsa:8431
UCSCiuc001bnf.4 human

Organism-specific databases

CTDi8431
DisGeNETi8431
EuPathDBiHostDB:ENSG00000131910.4
GeneCardsiNR0B2
HGNCiHGNC:7961 NR0B2
MalaCardsiNR0B2
MIMi601665 phenotype
604630 gene
neXtProtiNX_Q15466
OpenTargetsiENSG00000131910
PharmGKBiPA31747
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00390000015719
HOGENOMiHOG000231151
HOVERGENiHBG008136
InParanoidiQ15466
KOiK08563
OMAiCQLPPQD
OrthoDBiEOG091G0FGK
PhylomeDBiQ15466
TreeFamiTF332386

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
SignaLinkiQ15466
SIGNORiQ15466

Miscellaneous databases

EvolutionaryTraceiQ15466
GeneWikiiSmall_heterodimer_partner
GenomeRNAii8431
PROiPR:Q15466
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131910 Expressed in 75 organ(s), highest expression level in right lobe of liver
CleanExiHS_NR0B2
GenevisibleiQ15466 HS

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNR0B2_HUMAN
AccessioniPrimary (citable) accession number: Q15466
Secondary accession number(s): F1D8P5, Q5QP36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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