NR0B2

Functionⁱ

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.1 Publication

GO - Molecular functionⁱ

DNA binding Source: InterPro
peroxisome proliferator activated receptor binding Source: Ensembl
protein-containing complex binding Source: Ensembl
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17686645
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 16709599
retinoid X receptor binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
steroid hormone receptor activity Source: InterPro
thyroid hormone receptor binding Source: Ensembl
transcription corepressor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 14752053

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ regeneration Source: Ensembl
cholesterol metabolic process
Source: ProtInc
Traceable author statementⁱ
- 11030331
negative regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 14752053
negative regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19085950
negative regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 11030331
Notch signaling pathway Source: Ensembl
positive regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19085950
positive regulation of insulin secretion Source: Ensembl
response to glucose Source: Ensembl
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-383280 Nuclear Receptor transcription pathway
SignaLinkⁱ	Q15466
SIGNORⁱ	Q15466

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor subfamily 0 group B member 2 Alternative name(s): Orphan nuclear receptor SHP Small heterodimer partner
Gene namesⁱ	Name:NR0B2 Synonyms:SHP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131910.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7961 NR0B2
MIMⁱ	604630 gene
neXtProtⁱ	NX_Q15466

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Obesity (OBESITY)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

Keywords - Diseaseⁱ

Disease mutation, Obesity

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8431
MalaCards human disease database More...MalaCardsⁱ	NR0B2
MIMⁱ	601665 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000131910
PharmGKBⁱ	PA31747

Chemistry databases

ChEMBLⁱ	CHEMBL5603
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	636

Polymorphism and mutation databases

BioMutaⁱ	NR0B2
DMDMⁱ	9978744

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053752	1 – 257	Nuclear receptor subfamily 0 group B member 2Add BLAST		257

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	54	Symmetric dimethylarginineBy similarity		1
Modified residueⁱ	57	Symmetric dimethylarginine; by PRMT5By similarity		1

Post-translational modificationⁱ

Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.By similarity

Keywords - PTMⁱ

Methylation

Proteomic databases

PaxDbⁱ	Q15466
PeptideAtlas More...PeptideAtlasⁱ	Q15466
PRIDEⁱ	Q15466
ProteomicsDBⁱ	60603

PTM databases

iPTMnetⁱ	Q15466
PhosphoSitePlusⁱ	Q15466

Expressionⁱ

Tissue specificityⁱ

Liver. Low levels of expression were detected in heart and pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000131910 Expressed in 75 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_NR0B2
Genevisibleⁱ	Q15466 HS

Interactionⁱ

Subunit structureⁱ

Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2.By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HDAC1	Q13547	2	EBI-3910729,EBI-301834
HDAC3	O15379	2	EBI-3910729,EBI-607682
MDM2	Q00987	4	EBI-3910729,EBI-389668
NR5A2	O00482-1	2	EBI-3910729,EBI-15960777
SIRT1	Q96EB6	6	EBI-3910729,EBI-1802965
TP53	P04637	3	EBI-3910729,EBI-366083

GO - Molecular functionⁱ

peroxisome proliferator activated receptor binding Source: Ensembl
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17686645
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 16709599
retinoid X receptor binding Source: Ensembl
thyroid hormone receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114012, 62 interactors
CORUMⁱ	Q15466
Database of interacting proteins More...DIPⁱ	DIP-46313N
IntActⁱ	Q15466, 24 interactors
Molecular INTeraction database More...MINTⁱ	Q15466
STRINGⁱ	9606.ENSP00000254227

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	14 – 16	Combined sources	3
Helixⁱ	19 – 26	Combined sources	8
Helixⁱ	118 – 122	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15466
SMRⁱ	Q15466
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q15466

EvolutionaryTraceⁱ

Q15466

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	16 – 257	NR LBDPROSITE-ProRule annotationAdd BLAST		242

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR0 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015719
HOGENOMⁱ	HOG000231151
HOVERGENⁱ	HBG008136
InParanoidⁱ	Q15466
KEGG Orthology (KO) More...KOⁱ	K08563
OMAⁱ	SPKEYAY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FGK
PhylomeDBⁱ	Q15466
TreeFamⁱ	TF332386

Family and domain databases

InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q15466-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTSQPGACP CQGAASRPAI LYALLSSSLK AVPRPRSRCL CRQHRPVQLC 
        60         70         80         90        100
APHRTCREAL DVLAKTVAFL RNLPSFWQLP PQDQRRLLQG CWGPLFLLGL 
       110        120        130        140        150
AQDAVTFEVA EAPVPSILKK ILLEEPSSSG GSGQLPDRPQ PSLAAVQWLQ 
       160        170        180        190        200
CCLESFWSLE LSPKEYACLK GTILFNPDVP GLQAASHIGH LQQEAHWVLC 
       210        220        230        240        250
EVLEPWCPAA QGRLTRVLLT ASTLKSIPTS LLGDLFFRPI IGDVDIAGLL 

GDMLLLR

Length:257

Mass (Da):28,058

Last modified:December 1, 2000 - v2

Checksum:ⁱ14BEE2B3FF46154A

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_026015	57	R → W in early-onset obesity; Japanese population; loss of methylation and repressor activity. 2 PublicationsCorresponds to variant dbSNP:rs777291973Ensembl.	1
Natural variantⁱVAR_050584	171	G → A. Corresponds to variant dbSNP:rs6659176Ensembl.	1
Natural variantⁱVAR_026016	189	G → E in early-onset obesity; Japanese population; strong decrease of repressor activity. 1 PublicationCorresponds to variant dbSNP:rs202154574Ensembl.	1
Natural variantⁱVAR_026017	195	A → S in early-onset obesity; Japanese population; slight decrease of repressor activity. 1 PublicationCorresponds to variant dbSNP:rs74315350EnsemblClinVar.	1
Natural variantⁱVAR_026018	213	R → C in early-onset obesity; Japanese population; loss of repressor activity. 1 PublicationCorresponds to variant dbSNP:rs199976415Ensembl.	1
Natural variantⁱVAR_026019	216	R → H No effect on repressor activity. 1 PublicationCorresponds to variant dbSNP:rs200475847Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L76571 Genomic DNA Translation: AAC41998.1 AB058644 Genomic DNA Translation: BAB68530.1 HQ692833 mRNA Translation: ADZ17344.1 AL356390 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07781.1 BC030207 mRNA Translation: AAH30207.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS291.1
NCBI Reference Sequences More...RefSeqⁱ	NP_068804.1, NM_021969.2
UniGeneⁱ	Hs.427055

Genome annotation databases

Ensemblⁱ	ENST00000254227; ENSP00000254227; ENSG00000131910
GeneIDⁱ	8431
KEGGⁱ	hsa:8431
UCSC genome browser More...UCSCⁱ	uc001bnf.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15466	NR0B2 (Fragment)		PONPY		112	UniRef90_Q15466
Nuclear receptor subfamily 0 group B member 2		GORGO		267
NR0B2 isoform 1		PANTR		257
Nuclear receptor subfamily 0 group B member 2		PANPA		257
Nuclear receptor subfamily 0 group B member 2		MACMU		257
+26

Protein	Similar proteins		Species	Score	Length	Source
Q15466	NR0B2 (Fragment)		PONPY		112	UniRef50_Q15466
Nuclear receptor subfamily 0 group B member 2		GORGO		267
NR0B2 isoform 1		PANTR		257
Nuclear receptor subfamily 0 group B member 2		PANPA		257
Nuclear receptor subfamily 0 group B member 2		CHLSB		257
+54

Entry informationⁱ

Entry nameⁱ	NR0B2_HUMAN
Accessionⁱ	Q15466Primary (citable) accession number: Q15466 Secondary accession number(s): F1D8P5, Q5QP36
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	December 1, 2000
	Last modified:	September 12, 2018
	This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15466 (NR0B2_HUMAN)

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Nuclear receptor subfamily 0 group B member 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ