SHB

Functionⁱ

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.10 Publications

GO - Molecular functionⁱ

phosphotyrosine residue binding
Source: CAFA
Inferred from physical interactionⁱ
- 20624904
SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 8302579

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: UniProtKB-KW
apoptotic process Source: UniProtKB-KW
cell differentiation Source: UniProtKB-KW
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8302579
vascular endothelial growth factor receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Angiogenesis, Apoptosis, Differentiation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-4420097 VEGFA-VEGFR2 Pathway
SignaLinkⁱ	Q15464

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SH2 domain-containing adapter protein B
Gene namesⁱ	Name:SHB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107338.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10838 SHB
MIMⁱ	600314 gene
neXtProtⁱ	NX_Q15464

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	435	R → K: Loss of interaction with CD3Z. Alters LAT, PLCG1, VAV1 and LCP2 phosphorylation, MAP kinase signaling, Rac1 and JNK activation, intracellular calcium increase, activation of the nuclear factor for activation of T-cells and subsequent interleukin-2 expression which normally occur upon T-cells stimulation. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6461
Open Targets More...OpenTargetsⁱ	ENSG00000107338
PharmGKBⁱ	PA35744

Polymorphism and mutation databases

BioMutaⁱ	SHB
DMDMⁱ	110816415

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000246324	1 – 509	SH2 domain-containing adapter protein BAdd BLAST		509

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	102	PhosphoserineCombined sources	1
Cross-linkⁱ	187	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	307	PhosphoserineCombined sources	1
Modified residueⁱ	317	PhosphoserineCombined sources	1
Modified residueⁱ	388	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q15464
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15464
PaxDbⁱ	Q15464
PeptideAtlas More...PeptideAtlasⁱ	Q15464
PRIDEⁱ	Q15464
ProteomicsDBⁱ	60600 60601 [Q15464-2]

PTM databases

iPTMnetⁱ	Q15464
PhosphoSitePlusⁱ	Q15464

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000107338 Expressed in 205 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_SHB
Genevisibleⁱ	Q15464 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010161 HPA049911 HPA052108

HPAⁱ

CAB010161
HPA049911
HPA052108

Interactionⁱ

Subunit structureⁱ

Interacts with PTPN11 (By similarity). Interacts with phosphorylated 'Tyr-720' of the ligand-activated receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and GRAP. Interacts with CD3Z. Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation. Interacts with PLCG1. Interacts with ZAP70, LCP2/SLP-76, VAV1 and GRAP2. Interacts with JAK1 and JAK3. Interacts with PTK2/FAK1. Interacts with CRK/CrKII. Interacts with IRS2.By similarity12 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ABL1	P00519	5	EBI-4402156,EBI-375543
KIT	P10721	2	EBI-4402156,EBI-1379503
MET	P08581	4	EBI-4402156,EBI-1039152

GO - Molecular functionⁱ

phosphotyrosine residue binding
Source: CAFA
Inferred from physical interactionⁱ
- 20624904
SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 8302579

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112358, 23 interactors
IntActⁱ	Q15464, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q15464
STRINGⁱ	9606.ENSP00000366936

Chemistry databases

BindingDBⁱ	Q15464

BindingDBⁱ

Q15464

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15464
SMRⁱ	Q15464
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	410 – 504	SH2PROSITE-ProRule annotationAdd BLAST		95

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 410	Mediates interaction with LAT, PTK2/FAK1, JAK1 and JAK32 PublicationsAdd BLAST		410

Domainⁱ

The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.

Keywords - Domainⁱ

SH2 domain

Phylogenomic databases

eggNOGⁱ	ENOG410IGWI Eukaryota ENOG410XQJ2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015203
HOGENOMⁱ	HOG000038038
HOVERGENⁱ	HBG066172
InParanoidⁱ	Q15464
OMAⁱ	PAAASCF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I06
PhylomeDBⁱ	Q15464
TreeFamⁱ	TF325799

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10389 SH2_SHB, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR035040 SHB IPR035045 SHB_SH2
PANTHERⁱ	PTHR15127:SF31 PTHR15127:SF31, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit
SUPFAMⁱ	SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q15464-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKWLNKYFS LGNSKTKSPP QPPRPDYREQ RRRGERPSQP PQAVPQASSA 
        60         70         80         90        100
ASASCGPATA SCFSASSGSL PDDSGSTSDL IRAYRAQKER DFEDPYNGPG 
       110        120        130        140        150
SSLRKLRAMC RLDYCGGSGE PGGVQRAFSA SSASGAAGCC CASSGAGAAA 
       160        170        180        190        200
SSSSSSGSPH LYRSSSERRP ATPAEVRYIS PKHRLIKVES AAGGGAGDPL 
       210        220        230        240        250
GGACAGGRTW SPTACGGKKL LNKCAASAAE ESGAGKKDKV TIADDYSDPF 
       260        270        280        290        300
DAKNDLKSKA GKGESAGYME PYEAQRIMTE FQRQESVRSQ HKGIQLYDTP 
       310        320        330        340        350
YEPEGQSVDS DSESTVSPRL RESKLPQDDD RPADEYDQPW EWNRVTIPAL 
       360        370        380        390        400
AAQFNGNEKR QSSPSPSRDR RRQLRAPGGG FKPIKHGSPE FCGILGERVD 
       410        420        430        440        450
PAVPLEKQIW YHGAISRGDA ENLLRLCKEC SYLVRNSQTS KHDYSLSLRS 
       460        470        480        490        500
NQGFMHMKLA KTKEKYVLGQ NSPPFDSVPE VIHYYTTRKL PIKGAEHLSL 

LYPVAVRTL

Length:509

Mass (Da):55,042

Last modified:July 25, 2006 - v2

Checksum:ⁱ15C392A6EEB761D6

GO

Isoform 2 (identifier: Q15464-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
280-297: EFQRQESVRSQHKGIQLY → GLQEAWRHSPSGCFPVGP
298-509: Missing.

« Hide

        10         20         30         40         50
MAKWLNKYFS LGNSKTKSPP QPPRPDYREQ RRRGERPSQP PQAVPQASSA 
        60         70         80         90        100
ASASCGPATA SCFSASSGSL PDDSGSTSDL IRAYRAQKER DFEDPYNGPG 
       110        120        130        140        150
SSLRKLRAMC RLDYCGGSGE PGGVQRAFSA SSASGAAGCC CASSGAGAAA 
       160        170        180        190        200
SSSSSSGSPH LYRSSSERRP ATPAEVRYIS PKHRLIKVES AAGGGAGDPL 
       210        220        230        240        250
GGACAGGRTW SPTACGGKKL LNKCAASAAE ESGAGKKDKV TIADDYSDPF 
       260        270        280        290 
DAKNDLKSKA GKGESAGYME PYEAQRIMTG LQEAWRHSPS GCFPVGP

Note: No experimental confirmation available.

Show »

Length:297

Mass (Da):30,703

Checksum:ⁱ81ECB44A67B0D8AD

GO

Sequence cautionⁱ

The sequence AAH94765 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAA53091 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	91 – 93	DFE → HFQ in CAA53091 (PubMed:8302579).Curated	3
Sequence conflictⁱ	347	I → S in CAA53091 (PubMed:8302579).Curated	1
Sequence conflictⁱ	445	S → P in CAA53091 (PubMed:8302579).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_019846	280 – 297	EFQRQ…GIQLY → GLQEAWRHSPSGCFPVGP in isoform 2. 1 PublicationAdd BLAST		18
Alternative sequenceⁱVSP_019847	298 – 509	Missing in isoform 2. 1 PublicationAdd BLAST		212

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X75342 mRNA Translation: CAA53091.1 Different initiation. AL138752 Genomic DNA No translation available. AL161448 Genomic DNA No translation available. AL583849 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58254.1 CH471071 Genomic DNA Translation: EAW58255.1 BC094765 mRNA Translation: AAH94765.1 Different initiation. BC136581 mRNA Translation: AAI36582.1 BC136582 mRNA Translation: AAI36583.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43806.1 [Q15464-1]
PIRⁱ	I38228
NCBI Reference Sequences More...RefSeqⁱ	NP_003019.2, NM_003028.2 [Q15464-1]
UniGeneⁱ	Hs.521482

Genome annotation databases

Ensemblⁱ	ENST00000377707; ENSP00000366936; ENSG00000107338 [Q15464-1]
GeneIDⁱ	6461
KEGGⁱ	hsa:6461
UCSC genome browser More...UCSCⁱ	uc004aax.4 human [Q15464-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15464	SH2 domain containing adaptor protein B		PANTR		509	UniRef100_Q15464
Uncharacterized protein		PANPA		285
UPI000D500AA9		PANPA		241

Protein	Similar proteins		Species	Score	Length	Source
Q15464	SH2 domain-containing adapter protein B		MOUSE		503	UniRef90_Q15464
SH2 domain containing adaptor protein B		PANTR		509
Uncharacterized protein		PANPA		285
LOW QUALITY PROTEIN: SH2 domain-containing adapter protein B		LIPVE		595
Uncharacterized protein		RABIT		513
+76
Q15464-2	Uncharacterized protein		NEOLE		238	UniRef90_Q15464-2
UPI000C878160		PTEVA		292
UPI000C87A48C		PTEVA		288

Protein	Similar proteins		Species	Score	Length	Source
Q15464	SH2 domain-containing adapter protein B		MOUSE		503	UniRef50_Q15464
SH2 domain containing adaptor protein B		PANTR		509
Uncharacterized protein		PANPA		285
LOW QUALITY PROTEIN: SH2 domain-containing adapter protein B		LIPVE		595
Uncharacterized protein		RABIT		513
+92
Q15464-2	Uncharacterized protein		NEOLE		238	UniRef50_Q15464-2
Uncharacterized protein		MONDO		313
UPI000C878160		PTEVA		292
UPI0008546CF0		Nanorana parkeri		280
UPI0004541DCB		ORNAN		317
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X75342 mRNA Translation: CAA53091.1 Different initiation. AL138752 Genomic DNA No translation available. AL161448 Genomic DNA No translation available. AL583849 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58254.1 CH471071 Genomic DNA Translation: EAW58255.1 BC094765 mRNA Translation: AAH94765.1 Different initiation. BC136581 mRNA Translation: AAI36582.1 BC136582 mRNA Translation: AAI36583.1
CCDSⁱ	CCDS43806.1 [Q15464-1]
PIRⁱ	I38228
RefSeqⁱ	NP_003019.2, NM_003028.2 [Q15464-1]
UniGeneⁱ	Hs.521482

3D structure databases

ProteinModelPortalⁱ	Q15464
SMRⁱ	Q15464
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112358, 23 interactors
IntActⁱ	Q15464, 9 interactors
MINTⁱ	Q15464
STRINGⁱ	9606.ENSP00000366936

Chemistry databases

BindingDBⁱ	Q15464

BindingDBⁱ

Q15464

PTM databases

iPTMnetⁱ	Q15464
PhosphoSitePlusⁱ	Q15464

Polymorphism and mutation databases

BioMutaⁱ	SHB
DMDMⁱ	110816415

Proteomic databases

EPDⁱ	Q15464
MaxQBⁱ	Q15464
PaxDbⁱ	Q15464
PeptideAtlasⁱ	Q15464
PRIDEⁱ	Q15464
ProteomicsDBⁱ	60600 60601 [Q15464-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000377707; ENSP00000366936; ENSG00000107338 [Q15464-1]
GeneIDⁱ	6461
KEGGⁱ	hsa:6461
UCSCⁱ	uc004aax.4 human [Q15464-1]

Organism-specific databases

CTDⁱ	6461
DisGeNETⁱ	6461
EuPathDBⁱ	HostDB:ENSG00000107338.9
GeneCardsⁱ	SHB
H-InvDBⁱ	HIX0008049 HIX0079163 HIX0189186
HGNCⁱ	HGNC:10838 SHB
HPAⁱ	CAB010161 HPA049911 HPA052108
MIMⁱ	600314 gene
neXtProtⁱ	NX_Q15464
OpenTargetsⁱ	ENSG00000107338
PharmGKBⁱ	PA35744
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGWI Eukaryota ENOG410XQJ2 LUCA
GeneTreeⁱ	ENSGT00390000015203
HOGENOMⁱ	HOG000038038
HOVERGENⁱ	HBG066172
InParanoidⁱ	Q15464
OMAⁱ	PAAASCF
OrthoDBⁱ	EOG091G0I06
PhylomeDBⁱ	Q15464
TreeFamⁱ	TF325799

Enzyme and pathway databases

Reactomeⁱ	R-HSA-4420097 VEGFA-VEGFR2 Pathway
SignaLinkⁱ	Q15464

Miscellaneous databases

ChiTaRSⁱ	SHB human
GeneWikiⁱ	SHB_(gene)
GenomeRNAiⁱ	6461
Protein Ontology More...PROⁱ	PR:Q15464
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107338 Expressed in 205 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_SHB
Genevisibleⁱ	Q15464 HS

Family and domain databases

CDDⁱ	cd10389 SH2_SHB, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR035040 SHB IPR035045 SHB_SH2
PANTHERⁱ	PTHR15127:SF31 PTHR15127:SF31, 1 hit
Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit
SUPFAMⁱ	SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SHB_HUMAN
Accessionⁱ	Q15464Primary (citable) accession number: Q15464 Secondary accession number(s): B9EGM0 , D3DRQ5, Q504U5, Q5VUM8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
	Last sequence update:	July 25, 2006
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q15464 (SHB_HUMAN)

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SH2 domain-containing adapter protein B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ