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UniProtKB - Q15464 (SHB_HUMAN)

Entry version 165 (23 Feb 2022)
Sequence version 2 (25 Jul 2006)
Previous versions | rss
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Protein

SH2 domain-containing adapter protein B

Gene

SHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

10 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • apoptotic process Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB-KW
  • signal transduction Source: ProtInc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Apoptosis, Differentiation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15464

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-4420097, VEGFA-VEGFR2 Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15464

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH2 domain-containing adapter protein B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10838, SHB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600314, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15464

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000107338

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi435R → K: Loss of interaction with CD3Z. Alters LAT, PLCG1, VAV1 and LCP2 phosphorylation, MAP kinase signaling, Rac1 and JNK activation, intracellular calcium increase, activation of the nuclear factor for activation of T-cells and subsequent interleukin-2 expression which normally occur upon T-cells stimulation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6461

Open Targets

More...OpenTargetsi		ENSG00000107338

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35744

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15464, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SHB

Domain mapping of disease mutations (DMDM)

More...DMDMi		110816415

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002463241 – 509SH2 domain-containing adapter protein BAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki187Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei307PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei388PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15464

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15464

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15464

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15464

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15464

PeptideAtlas

More...PeptideAtlasi		Q15464

PRoteomics IDEntifications database

More...PRIDEi		Q15464

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60600 [Q15464-1]
60601 [Q15464-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15464

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15464

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000107338, Expressed in amniotic fluid and 219 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15464, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000107338, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPN11 (By similarity).

Interacts with phosphorylated 'Tyr-720' of the ligand-activated receptor PDGFRA via its SH2 domain.

Interacts with the ligand-activated receptors PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and IL2RG.

Interacts with EPS8 and V-SRC.

Interacts with GRB2 and GRAP.

Interacts with CD3Z.

Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation.

Interacts with PLCG1.

Interacts with ZAP70, LCP2/SLP-76, VAV1 and GRAP2.

Interacts with JAK1 and JAK3.

Interacts with PTK2/FAK1.

Interacts with CRK/CrKII.

Interacts with IRS2.

By similarity12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112358, 65 interactors

Protein interaction database and analysis system

More...IntActi		Q15464, 14 interactors

Molecular INTeraction database

More...MINTi		Q15464

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366936

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q15464

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15464, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15464

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini410 – 504SH2PROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 410Mediates interaction with LAT, PTK2/FAK1, JAK1 and JAK32 PublicationsAdd BLAST410
Regioni1 – 103DisorderedSequence analysisAdd BLAST103
Regioni144 – 178DisorderedSequence analysisAdd BLAST35
Regioni229 – 385DisorderedSequence analysisAdd BLAST157

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 36Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi41 – 76Polar residuesSequence analysisAdd BLAST36
Compositional biasi146 – 165Polar residuesSequence analysisAdd BLAST20
Compositional biasi232 – 260Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi279 – 293Polar residuesSequence analysisAdd BLAST15
Compositional biasi315 – 338Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RT81, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029444_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15464

Identification of Orthologs from Complete Genome Data

More...OMAi		SERKWIG

Database of Orthologous Groups

More...OrthoDBi		1120795at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15464

TreeFam database of animal gene trees

More...TreeFami		TF325799

Family and domain databases

Conserved Domains Database

More...CDDi		cd10389, SH2_SHB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR035040, SHB
IPR035045, SHB_SH2

The PANTHER Classification System

More...PANTHERi		PTHR15127:SF31, PTHR15127:SF31, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00017, SH2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00401, SH2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00252, SH2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q15464-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKWLNKYFS LGNSKTKSPP QPPRPDYREQ RRRGERPSQP PQAVPQASSA 
        60         70         80         90        100
ASASCGPATA SCFSASSGSL PDDSGSTSDL IRAYRAQKER DFEDPYNGPG 
       110        120        130        140        150
SSLRKLRAMC RLDYCGGSGE PGGVQRAFSA SSASGAAGCC CASSGAGAAA 
       160        170        180        190        200
SSSSSSGSPH LYRSSSERRP ATPAEVRYIS PKHRLIKVES AAGGGAGDPL 
       210        220        230        240        250
GGACAGGRTW SPTACGGKKL LNKCAASAAE ESGAGKKDKV TIADDYSDPF 
       260        270        280        290        300
DAKNDLKSKA GKGESAGYME PYEAQRIMTE FQRQESVRSQ HKGIQLYDTP 
       310        320        330        340        350
YEPEGQSVDS DSESTVSPRL RESKLPQDDD RPADEYDQPW EWNRVTIPAL 
       360        370        380        390        400
AAQFNGNEKR QSSPSPSRDR RRQLRAPGGG FKPIKHGSPE FCGILGERVD 
       410        420        430        440        450
PAVPLEKQIW YHGAISRGDA ENLLRLCKEC SYLVRNSQTS KHDYSLSLRS 
       460        470        480        490        500
NQGFMHMKLA KTKEKYVLGQ NSPPFDSVPE VIHYYTTRKL PIKGAEHLSL 

LYPVAVRTL
Length:509
Mass (Da):55,042
Last modified:July 25, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15C392A6EEB761D6
GO
Isoform 2 (identifier: Q15464-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-297: EFQRQESVRSQHKGIQLY → GLQEAWRHSPSGCFPVGP
     298-509: Missing.

Show »
Length:297
Mass (Da):30,703
Checksum:i81ECB44A67B0D8AD
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH94765 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA53091 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91 – 93DFE → HFQ in CAA53091 (PubMed:8302579).Curated3
Sequence conflicti347I → S in CAA53091 (PubMed:8302579).Curated1
Sequence conflicti445S → P in CAA53091 (PubMed:8302579).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019846280 – 297EFQRQ…GIQLY → GLQEAWRHSPSGCFPVGP in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_019847298 – 509Missing in isoform 2. 1 PublicationAdd BLAST212

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X75342 mRNA Translation: CAA53091.1 Different initiation.
AL138752 Genomic DNA No translation available.
AL161448 Genomic DNA No translation available.
AL583849 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58254.1
CH471071 Genomic DNA Translation: EAW58255.1
BC094765 mRNA Translation: AAH94765.1 Different initiation.
BC136581 mRNA Translation: AAI36582.1
BC136582 mRNA Translation: AAI36583.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43806.1 [Q15464-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I38228

NCBI Reference Sequences

More...RefSeqi		NP_003019.2, NM_003028.2 [Q15464-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377707; ENSP00000366936; ENSG00000107338

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6461

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6461

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000377707.4; ENSP00000366936.3; NM_003028.3; NP_003019.2

UCSC genome browser

More...UCSCi		uc004aax.4, human [Q15464-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75342 mRNA Translation: CAA53091.1 Different initiation.
AL138752 Genomic DNA No translation available.
AL161448 Genomic DNA No translation available.
AL583849 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58254.1
CH471071 Genomic DNA Translation: EAW58255.1
BC094765 mRNA Translation: AAH94765.1 Different initiation.
BC136581 mRNA Translation: AAI36582.1
BC136582 mRNA Translation: AAI36583.1
CCDSiCCDS43806.1 [Q15464-1]
PIRiI38228
RefSeqiNP_003019.2, NM_003028.2 [Q15464-1]

3D structure databases

SMRiQ15464
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112358, 65 interactors
IntActiQ15464, 14 interactors
MINTiQ15464
STRINGi9606.ENSP00000366936

Chemistry databases

BindingDBiQ15464

PTM databases

iPTMnetiQ15464
PhosphoSitePlusiQ15464

Genetic variation databases

BioMutaiSHB
DMDMi110816415

Proteomic databases

EPDiQ15464
jPOSTiQ15464
MassIVEiQ15464
MaxQBiQ15464
PaxDbiQ15464
PeptideAtlasiQ15464
PRIDEiQ15464
ProteomicsDBi60600 [Q15464-1]
60601 [Q15464-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4119, 287 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		6461

Genome annotation databases

EnsembliENST00000377707; ENSP00000366936; ENSG00000107338
GeneIDi6461
KEGGihsa:6461
MANE-SelectiENST00000377707.4; ENSP00000366936.3; NM_003028.3; NP_003019.2
UCSCiuc004aax.4, human [Q15464-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6461
DisGeNETi6461

GeneCards: human genes, protein and diseases

More...GeneCardsi		SHB
HGNCiHGNC:10838, SHB
HPAiENSG00000107338, Low tissue specificity
MIMi600314, gene
neXtProtiNX_Q15464
OpenTargetsiENSG00000107338
PharmGKBiPA35744
VEuPathDBiHostDB:ENSG00000107338

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RT81, Eukaryota
GeneTreeiENSGT00940000161591
HOGENOMiCLU_029444_0_0_1
InParanoidiQ15464
OMAiSERKWIG
OrthoDBi1120795at2759
PhylomeDBiQ15464
TreeFamiTF325799

Enzyme and pathway databases

PathwayCommonsiQ15464
ReactomeiR-HSA-4420097, VEGFA-VEGFR2 Pathway
SignaLinkiQ15464

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6461, 18 hits in 1047 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SHB, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SHB_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6461
PharosiQ15464, Tbio

Protein Ontology

More...PROi		PR:Q15464
RNActiQ15464, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000107338, Expressed in amniotic fluid and 219 other tissues
GenevisibleiQ15464, HS

Family and domain databases

CDDicd10389, SH2_SHB, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR035040, SHB
IPR035045, SHB_SH2
PANTHERiPTHR15127:SF31, PTHR15127:SF31, 1 hit
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PRINTSiPR00401, SH2DOMAIN
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SUPFAMiSSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15464
Secondary accession number(s): B9EGM0
, D3DRQ5, Q504U5, Q5VUM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: February 23, 2022
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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