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Entry version 180 (13 Nov 2019)
Sequence version 2 (23 Jan 2002)
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Protein

Protein transport protein Sec23B

Gene

SEC23B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi61ZincBy similarity1
Metal bindingi66ZincBy similarity1
Metal bindingi85ZincBy similarity1
Metal bindingi88ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein Sec23BCurated
Short name:
hSec23B1 Publication
Alternative name(s):
SEC23-related protein B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC23BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10702 SEC23B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610512 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15437

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cowden syndrome 7 (CWS7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Cowden syndrome, a hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid. CWS7 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076424164V → L in CWS7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs36023150EnsemblClinVar.1
Natural variantiVAR_076425594V → G in CWS7; aberrant aggregation; causes mislocalization of the protein in the cytoplasm; reduces interaction with SAR1A; confers endoplasmic reticulum (ER) stress-mediated cell growth advantage. 1 PublicationCorresponds to variant dbSNP:rs752366963EnsemblClinVar.1
Anemia, congenital dyserythropoietic, 2 (CDAN2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, normocytic anemia, iron overload, jaundice, and variable splenomegaly. Ultrastructural features include bi- or multinucleated erythroblasts in bone marrow, karyorrhexis, and the presence of Gaucher-like bone marrow histiocytes. The main biochemical feature of the disease is defective glycosylation of some red blood cells membrane proteins.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06229414R → W in CDAN2; the mutant protein is unstable with less than 5% of protein detectable compared to wild-type. 2 PublicationsCorresponds to variant dbSNP:rs121918222EnsemblClinVar.1
Natural variantiVAR_062296109E → K in CDAN2; the mutant protein is unstable with less than 5% of protein detectable compared to wild-type. 2 PublicationsCorresponds to variant dbSNP:rs121918221EnsemblClinVar.1
Natural variantiVAR_062300348D → A in CDAN2. 1 Publication1
Natural variantiVAR_062305497R → C in CDAN2; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs727504145EnsemblClinVar.1
Natural variantiVAR_062307530R → W in CDAN2. 1 PublicationCorresponds to variant dbSNP:rs121918223EnsemblClinVar.1
Natural variantiVAR_062308603S → L in CDAN2. 1 Publication1
Natural variantiVAR_062309701R → C in CDAN2. 1 PublicationCorresponds to variant dbSNP:rs201270568Ensembl.1

Keywords - Diseasei

Congenital dyserythropoietic anemia, Disease mutation, Hereditary hemolytic anemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
10483

MalaCards human disease database

More...
MalaCardsi
SEC23B
MIMi224100 phenotype
616858 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000101310

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98873 Congenital dyserythropoietic anemia type II
201 Cowden syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35625

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15437

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEC23B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141794

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002051482 – 767Protein transport protein Sec23BAdd BLAST766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei564N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15437

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15437

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q15437

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15437

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15437

PeptideAtlas

More...
PeptideAtlasi
Q15437

PRoteomics IDEntifications database

More...
PRIDEi
Q15437

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60596

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15437

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15437

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000101310 Expressed in 225 organ(s), highest expression level in adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15437 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15437 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008216
HPA069974

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (By similarity).

Interacts with SAR1A (PubMed:26522472).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115746, 116 interactors

Protein interaction database and analysis system

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IntActi
Q15437, 36 interactors

Molecular INTeraction database

More...
MINTi
Q15437

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338844

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15437

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati634 – 720Gelsolin-likeSequence analysisAdd BLAST87

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1986 Eukaryota
COG5047 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000006916

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15437

KEGG Orthology (KO)

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KOi
K14006

Identification of Orthologs from Complete Genome Data

More...
OMAi
PWNIIPV

Database of Orthologous Groups

More...
OrthoDBi
270617at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15437

TreeFam database of animal gene trees

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TreeFami
TF300693

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11287 Sec23_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.20.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR037364 Sec23
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR037550 Sec23_C
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11141 PTHR11141, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q15437-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPLAC LLTPLKERPD
60 70 80 90 100
LPPVQYEPVL CSRPTCKAVL NPLCQVDYRA KLWACNFCFQ RNQFPPAYGG
110 120 130 140 150
ISEVNQPAEL MPQFSTIEYV IQRGAQSPLI FLYVVDTCLE EDDLQALKES
160 170 180 190 200
LQMSLSLLPP DALVGLITFG RMVQVHELSC EGISKSYVFR GTKDLTAKQI
210 220 230 240 250
QDMLGLTKPA MPMQQARPAQ PQEHPFASSR FLQPVHKIDM NLTDLLGELQ
260 270 280 290 300
RDPWPVTQGK RPLRSTGVAL SIAVGLLEGT FPNTGARIML FTGGPPTQGP
310 320 330 340 350
GMVVGDELKI PIRSWHDIEK DNARFMKKAT KHYEMLANRT AANGHCIDIY
360 370 380 390 400
ACALDQTGLL EMKCCANLTG GYMVMGDSFN TSLFKQTFQR IFTKDFNGDF
410 420 430 440 450
RMAFGATLDV KTSRELKIAG AIGPCVSLNV KGPCVSENEL GVGGTSQWKI
460 470 480 490 500
CGLDPTSTLG IYFEVVNQHN TPIPQGGRGA IQFVTHYQHS STQRRIRVTT
510 520 530 540 550
IARNWADVQS QLRHIEAAFD QEAAAVLMAR LGVFRAESEE GPDVLRWLDR
560 570 580 590 600
QLIRLCQKFG QYNKEDPTSF RLSDSFSLYP QFMFHLRRSP FLQVFNNSPD
610 620 630 640 650
ESSYYRHHFA RQDLTQSLIM IQPILYSYSF HGPPEPVLLD SSSILADRIL
660 670 680 690 700
LMDTFFQIVI YLGETIAQWR KAGYQDMPEY ENFKHLLQAP LDDAQEILQA
710 720 730 740 750
RFPMPRYINT EHGGSQARFL LSKVNPSQTH NNLYAWGQET GAPILTDDVS
760
LQVFMDHLKK LAVSSAC
Length:767
Mass (Da):86,479
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A00DE39D56B0204
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YFH5A0A2R8YFH5_HUMAN
Protein transport protein SEC23
SEC23B
749Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QPE1Q5QPE1_HUMAN
Protein transport protein SEC23
SEC23B
246Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QPE2Q5QPE2_HUMAN
Protein transport protein SEC23
SEC23B
331Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y633A0A2R8Y633_HUMAN
Protein transport protein SEC23
SEC23B
52Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7S7A0A2R8Y7S7_HUMAN
Protein transport protein SEC23
SEC23B
59Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YF30A0A2R8YF30_HUMAN
Protein transport protein SEC23
SEC23B
32Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06229414R → W in CDAN2; the mutant protein is unstable with less than 5% of protein detectable compared to wild-type. 2 PublicationsCorresponds to variant dbSNP:rs121918222EnsemblClinVar.1
Natural variantiVAR_06229518R → H1 PublicationCorresponds to variant dbSNP:rs905074313Ensembl.1
Natural variantiVAR_062296109E → K in CDAN2; the mutant protein is unstable with less than 5% of protein detectable compared to wild-type. 2 PublicationsCorresponds to variant dbSNP:rs121918221EnsemblClinVar.1
Natural variantiVAR_076424164V → L in CWS7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs36023150EnsemblClinVar.1
Natural variantiVAR_062297239D → G The mutant protein is expressed as the wild-type. 1 PublicationCorresponds to variant dbSNP:rs761034212Ensembl.1
Natural variantiVAR_062298313R → H1 PublicationCorresponds to variant dbSNP:rs750888081Ensembl.1
Natural variantiVAR_062299318I → T1 PublicationCorresponds to variant dbSNP:rs953079477Ensembl.1
Natural variantiVAR_062300348D → A in CDAN2. 1 Publication1
Natural variantiVAR_062301373M → V1 PublicationCorresponds to variant dbSNP:rs17849992Ensembl.1
Natural variantiVAR_062302386Q → R1 Publication1
Natural variantiVAR_062303426V → I1 PublicationCorresponds to variant dbSNP:rs41309927EnsemblClinVar.1
Natural variantiVAR_034482433P → L1 PublicationCorresponds to variant dbSNP:rs17807673EnsemblClinVar.1
Natural variantiVAR_062304462Y → C1 PublicationCorresponds to variant dbSNP:rs780978419Ensembl.1
Natural variantiVAR_020318489H → Q2 PublicationsCorresponds to variant dbSNP:rs2273526EnsemblClinVar.1
Natural variantiVAR_062305497R → C in CDAN2; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs727504145EnsemblClinVar.1
Natural variantiVAR_062306524A → V1 PublicationCorresponds to variant dbSNP:rs398124225EnsemblClinVar.1
Natural variantiVAR_062307530R → W in CDAN2. 1 PublicationCorresponds to variant dbSNP:rs121918223EnsemblClinVar.1
Natural variantiVAR_076425594V → G in CWS7; aberrant aggregation; causes mislocalization of the protein in the cytoplasm; reduces interaction with SAR1A; confers endoplasmic reticulum (ER) stress-mediated cell growth advantage. 1 PublicationCorresponds to variant dbSNP:rs752366963EnsemblClinVar.1
Natural variantiVAR_062308603S → L in CDAN2. 1 Publication1
Natural variantiVAR_062309701R → C in CDAN2. 1 PublicationCorresponds to variant dbSNP:rs201270568Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X97065 mRNA Translation: CAA65775.1
AL121893 Genomic DNA No translation available.
AL121900 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10231.1
CH471133 Genomic DNA Translation: EAX10232.1
CH471133 Genomic DNA Translation: EAX10233.1
CH471133 Genomic DNA Translation: EAX10234.1
CH471133 Genomic DNA Translation: EAX10235.1
BC005032 mRNA Translation: AAH05032.1
BC005404 mRNA Translation: AAH05404.1
BC095404 mRNA Translation: AAH95404.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13137.1

NCBI Reference Sequences

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RefSeqi
NP_001166216.1, NM_001172745.1
NP_006354.2, NM_006363.4
NP_116780.1, NM_032985.4
NP_116781.1, NM_032986.3
XP_016883082.1, XM_017027593.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262544; ENSP00000262544; ENSG00000101310
ENST00000336714; ENSP00000338844; ENSG00000101310
ENST00000377465; ENSP00000366685; ENSG00000101310
ENST00000650089; ENSP00000497473; ENSG00000101310

Database of genes from NCBI RefSeq genomes

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GeneIDi
10483

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10483

UCSC genome browser

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UCSCi
uc002wqz.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97065 mRNA Translation: CAA65775.1
AL121893 Genomic DNA No translation available.
AL121900 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10231.1
CH471133 Genomic DNA Translation: EAX10232.1
CH471133 Genomic DNA Translation: EAX10233.1
CH471133 Genomic DNA Translation: EAX10234.1
CH471133 Genomic DNA Translation: EAX10235.1
BC005032 mRNA Translation: AAH05032.1
BC005404 mRNA Translation: AAH05404.1
BC095404 mRNA Translation: AAH95404.1
CCDSiCCDS13137.1
RefSeqiNP_001166216.1, NM_001172745.1
NP_006354.2, NM_006363.4
NP_116780.1, NM_032985.4
NP_116781.1, NM_032986.3
XP_016883082.1, XM_017027593.1

3D structure databases

SMRiQ15437
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115746, 116 interactors
IntActiQ15437, 36 interactors
MINTiQ15437
STRINGi9606.ENSP00000338844

PTM databases

iPTMnetiQ15437
PhosphoSitePlusiQ15437

Polymorphism and mutation databases

BioMutaiSEC23B
DMDMi20141794

Proteomic databases

EPDiQ15437
jPOSTiQ15437
MassIVEiQ15437
MaxQBiQ15437
PaxDbiQ15437
PeptideAtlasiQ15437
PRIDEiQ15437
ProteomicsDBi60596

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10483

Genome annotation databases

EnsembliENST00000262544; ENSP00000262544; ENSG00000101310
ENST00000336714; ENSP00000338844; ENSG00000101310
ENST00000377465; ENSP00000366685; ENSG00000101310
ENST00000650089; ENSP00000497473; ENSG00000101310
GeneIDi10483
KEGGihsa:10483
UCSCiuc002wqz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10483
DisGeNETi10483

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SEC23B
HGNCiHGNC:10702 SEC23B
HPAiHPA008216
HPA069974
MalaCardsiSEC23B
MIMi224100 phenotype
610512 gene
616858 phenotype
neXtProtiNX_Q15437
OpenTargetsiENSG00000101310
Orphaneti98873 Congenital dyserythropoietic anemia type II
201 Cowden syndrome
PharmGKBiPA35625

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1986 Eukaryota
COG5047 LUCA
GeneTreeiENSGT00390000006916
InParanoidiQ15437
KOiK14006
OMAiPWNIIPV
OrthoDBi270617at2759
PhylomeDBiQ15437
TreeFamiTF300693

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SEC23B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SEC23B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10483
PharosiQ15437

Protein Ontology

More...
PROi
PR:Q15437

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101310 Expressed in 225 organ(s), highest expression level in adrenal gland
ExpressionAtlasiQ15437 baseline and differential
GenevisibleiQ15437 HS

Family and domain databases

CDDicd11287 Sec23_C, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR037364 Sec23
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR037550 Sec23_C
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PANTHERiPTHR11141 PTHR11141, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC23B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15437
Secondary accession number(s): D3DW33
, Q503A9, Q5W183, Q9BS15, Q9BSI2, Q9H1D7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2002
Last modified: November 13, 2019
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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