PPP1R7

Functionⁱ

Regulatory subunit of protein phosphatase 1.By similarity

GO - Molecular functionⁱ

enzyme regulator activity
Source: UniProtKB
Non-traceable author statementⁱ
- 10231361
protein phosphatase regulator activity
Source: ProtInc
Traceable author statementⁱ
- 7498485

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of protein dephosphorylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 22801782

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein phosphatase 1 regulatory subunit 7 Alternative name(s): Protein phosphatase 1 regulatory subunit 22
Gene namesⁱ	Name:PPP1R7 Synonyms:SDS22
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000115685.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9295 PPP1R7
MIMⁱ	602877 gene
neXtProtⁱ	NX_Q15435

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	148	D → V: Completely abolishes the interaction with protein phosphatase 1. 1 Publication	1
Mutagenesisⁱ	170	F → A: Severely impaired the binding of protein phosphatase 1. 1 Publication	1
Mutagenesisⁱ	192	E → A: Completely abolishes the interaction with protein phosphatase 1. 1 Publication	1
Mutagenesisⁱ	214	F → A: Completely abolishes the interaction with protein phosphatase 1. 1 Publication	1
Mutagenesisⁱ	280	D → A: Severely impairs the binding of protein phosphatase 1. 1 Publication	1
Mutagenesisⁱ	300	E → A: Completely abolishes the interaction with protein phosphatase 1. 1 Publication	1
Mutagenesisⁱ	302	W → A: Completely abolishes the interaction with protein phosphatase 1. 1 Publication	1
Mutagenesisⁱ	327	Y → A: Completely abolishes the interaction with protein phosphatase 1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5510
Open Targets More...OpenTargetsⁱ	ENSG00000115685
PharmGKBⁱ	PA33658

Polymorphism and mutation databases

DMDMⁱ	74762145

DMDMⁱ

74762145

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000239613	2 – 360	Protein phosphatase 1 regulatory subunit 7Add BLAST		359

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	12	PhosphoserineCombined sources	1
Modified residueⁱ	24	PhosphoserineCombined sources	1
Modified residueⁱ	27	PhosphoserineCombined sources	1
Modified residueⁱ	44	PhosphoserineCombined sources	1
Modified residueⁱ	47	PhosphoserineCombined sources	1
Modified residueⁱ	322	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q15435
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15435
PaxDbⁱ	Q15435
PeptideAtlas More...PeptideAtlasⁱ	Q15435
PRIDEⁱ	Q15435
ProteomicsDBⁱ	60591 60592 [Q15435-2] 60593 [Q15435-3] 60594 [Q15435-4]

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00033600

REPRODUCTION-2DPAGEⁱ

IPI00033600

PTM databases

iPTMnetⁱ	Q15435
PhosphoSitePlusⁱ	Q15435

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000115685 Expressed in 233 organ(s), highest expression level in testis
CleanExⁱ	HS_PPP1R7
ExpressionAtlasⁱ	Q15435 baseline and differential
Genevisibleⁱ	Q15435 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA034500 HPA034501

HPAⁱ

HPA034500
HPA034501

Interactionⁱ

Subunit structureⁱ

Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G isoform 1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PPP1CA	P62136	6	EBI-1024281,EBI-357253
PPP1CB	P62140	8	EBI-1024281,EBI-352350
PPP1CC	P36873	5	EBI-1024281,EBI-356283
USHBP1	Q8N6Y0	3	EBI-1024281,EBI-739895

Protein-protein interaction databases

BioGridⁱ	111502, 60 interactors
Database of interacting proteins More...DIPⁱ	DIP-1005N
IntActⁱ	Q15435, 43 interactors
Molecular INTeraction database More...MINTⁱ	Q15435
STRINGⁱ	9606.ENSP00000234038

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15435
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	77 – 98	LRR 1Add BLAST	22
Repeatⁱ	99 – 120	LRR 2Add BLAST	22
Repeatⁱ	121 – 142	LRR 3Add BLAST	22
Repeatⁱ	143 – 164	LRR 4Add BLAST	22
Repeatⁱ	165 – 186	LRR 5Add BLAST	22
Repeatⁱ	187 – 208	LRR 6Add BLAST	22
Repeatⁱ	209 – 230	LRR 7Add BLAST	22
Repeatⁱ	231 – 252	LRR 8Add BLAST	22
Repeatⁱ	253 – 274	LRR 9Add BLAST	22
Repeatⁱ	275 – 296	LRR 10Add BLAST	22
Repeatⁱ	297 – 318	LRR 11Add BLAST	22
Domainⁱ	331 – 360	LRRCTAdd BLAST	30

Sequence similaritiesⁱ

Belongs to the SDS22 family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0531 Eukaryota COG4886 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150857
HOGENOMⁱ	HOG000211189
HOVERGENⁱ	HBG082161
InParanoidⁱ	Q15435
KEGG Orthology (KO) More...KOⁱ	K17550
OMAⁱ	LFLRWNL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FWO
PhylomeDBⁱ	Q15435
TreeFamⁱ	TF105538

Family and domain databases

Gene3Dⁱ	3.80.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR003603 U2A'_phosphoprotein32A_C
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 7 hits SM00446 LRRcap, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 12 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15435-1) [UniParc]FASTA Add to basket

Also known as: sds22alpha1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHSSGIV ADLSEQSLKD 
        60         70         80         90        100
GEERGEEDPE EEHELPVDME TINLDRDAED VDLNHYRIGK IEGFEVLKKV 
       110        120        130        140        150
KTLCLRQNLI KCIENLEELQ SLRELDLYDN QIKKIENLEA LTELEILDIS 
       160        170        180        190        200
FNLLRNIEGV DKLTRLKKLF LVNNKISKIE NLSNLHQLQM LELGSNRIRA 
       210        220        230        240        250
IENIDTLTNL ESLFLGKNKI TKLQNLDALT NLTVLSMQSN RLTKIEGLQN 
       260        270        280        290        300
LVNLRELYLS HNGIEVIEGL ENNNKLTMLD IASNRIKKIE NISHLTELQE 
       310        320        330        340        350
FWMNDNLLES WSDLDELKGA RSLETVYLER NPLQKDPQYR RKVMLALPSV 
       360
RQIDATFVRF

Length:360

Mass (Da):41,564

Last modified:November 1, 1996 - v1

Checksum:ⁱ49BCCF675EAA94D1

GO

Isoform 2 (identifier: Q15435-2) [UniParc]FASTA Add to basket

Also known as: sds22alpha2

The sequence of this isoform differs from the canonical sequence as follows:
18-60: Missing.

« Hide

        10         20         30         40         50
MAAERGAGQQ QSQEMMEEEH ELPVDMETIN LDRDAEDVDL NHYRIGKIEG 
        60         70         80         90        100
FEVLKKVKTL CLRQNLIKCI ENLEELQSLR ELDLYDNQIK KIENLEALTE 
       110        120        130        140        150
LEILDISFNL LRNIEGVDKL TRLKKLFLVN NKISKIENLS NLHQLQMLEL 
       160        170        180        190        200
GSNRIRAIEN IDTLTNLESL FLGKNKITKL QNLDALTNLT VLSMQSNRLT 
       210        220        230        240        250
KIEGLQNLVN LRELYLSHNG IEVIEGLENN NKLTMLDIAS NRIKKIENIS 
       260        270        280        290        300
HLTELQEFWM NDNLLESWSD LDELKGARSL ETVYLERNPL QKDPQYRRKV 
       310 
MLALPSVRQI DATFVRF

Show »

Length:317

Mass (Da):36,837

Checksum:ⁱ9AC120B3C729CF8B

GO

Isoform 3 (identifier: Q15435-3) [UniParc]FASTA Add to basket

Also known as: sds22beta1

The sequence of this isoform differs from the canonical sequence as follows:
274-280: NKLTMLD → VQDSLTY
281-360: Missing.

« Hide

        10         20         30         40         50
MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHSSGIV ADLSEQSLKD 
        60         70         80         90        100
GEERGEEDPE EEHELPVDME TINLDRDAED VDLNHYRIGK IEGFEVLKKV 
       110        120        130        140        150
KTLCLRQNLI KCIENLEELQ SLRELDLYDN QIKKIENLEA LTELEILDIS 
       160        170        180        190        200
FNLLRNIEGV DKLTRLKKLF LVNNKISKIE NLSNLHQLQM LELGSNRIRA 
       210        220        230        240        250
IENIDTLTNL ESLFLGKNKI TKLQNLDALT NLTVLSMQSN RLTKIEGLQN 
       260        270        280
LVNLRELYLS HNGIEVIEGL ENNVQDSLTY

Show »

Length:280

Mass (Da):32,053

Checksum:ⁱ4FE43AE30C65AB72

GO

Isoform 4 (identifier: Q15435-4) [UniParc]FASTA Add to basket

Also known as: sds22beta2

The sequence of this isoform differs from the canonical sequence as follows:
     18-60: Missing.
     274-280: NKLTMLD → VQDSLTY
     281-360: Missing.

« Hide

        10         20         30         40         50
MAAERGAGQQ QSQEMMEEEH ELPVDMETIN LDRDAEDVDL NHYRIGKIEG 
        60         70         80         90        100
FEVLKKVKTL CLRQNLIKCI ENLEELQSLR ELDLYDNQIK KIENLEALTE 
       110        120        130        140        150
LEILDISFNL LRNIEGVDKL TRLKKLFLVN NKISKIENLS NLHQLQMLEL 
       160        170        180        190        200
GSNRIRAIEN IDTLTNLESL FLGKNKITKL QNLDALTNLT VLSMQSNRLT 
       210        220        230 
KIEGLQNLVN LRELYLSHNG IEVIEGLENN VQDSLTY

Show »

Length:237

Mass (Da):27,326

Checksum:ⁱ627A59386B5763BB

GO

Isoform 5 (identifier: Q15435-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE → M
     274-280: NKLTMLD → VQDSLTY
     281-360: Missing.

« Hide

        10         20         30         40         50
MEEHELPVDM ETINLDRDAE DVDLNHYRIG KIEGFEVLKK VKTLCLRQNL 
        60         70         80         90        100
IKCIENLEEL QSLRELDLYD NQIKKIENLE ALTELEILDI SFNLLRNIEG 
       110        120        130        140        150
VDKLTRLKKL FLVNNKISKI ENLSNLHQLQ MLELGSNRIR AIENIDTLTN 
       160        170        180        190        200
LESLFLGKNK ITKLQNLDAL TNLTVLSMQS NRLTKIEGLQ NLVNLRELYL 
       210        220 
SHNGIEVIEG LENNVQDSLT Y

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »

Length:221

Mass (Da):25,593

Checksum:ⁱ9AB66B080F2F52C0

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B5MBZ8	B5MBZ8_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 7	PPP1R7	274	Annotation score:
C9J177	C9J177_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 7	PPP1R7	289	Annotation score:
C9JD73	C9JD73_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 7	PPP1R7	282	Annotation score:
C9JRC4	C9JRC4_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 7	PPP1R7	184	Annotation score:
H7C118	H7C118_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 7	PPP1R7	140	Annotation score:
H7C003	H7C003_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 7	PPP1R7	335	Annotation score:
H7C3Q5	H7C3Q5_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 7	PPP1R7	108	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055672	1 – 60	MAAER…EEDPE → M in isoform 5. CuratedAdd BLAST	60
Alternative sequenceⁱVSP_019244	18 – 60	Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST	43
Alternative sequenceⁱVSP_019245	274 – 280	NKLTMLD → VQDSLTY in isoform 3, isoform 4 and isoform 5. 2 Publications	7
Alternative sequenceⁱVSP_019246	281 – 360	Missing in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST	80

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z50749 mRNA Translation: CAA90626.1 AF067136 AF067135 Genomic DNA Translation: AAD26610.1 AF067136 AF067131 Genomic DNA Translation: AAD26611.1 AF067134 AF067133 Genomic DNA Translation: AAD26612.1 AF067134 , AF067132, AF067130, AF067133 Genomic DNA Translation: AAD26613.1 BT007296 mRNA Translation: AAP35960.1 BT020134 mRNA Translation: AAV38936.1 AK294043 mRNA Translation: BAG57395.1 AC005237 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW71243.1 BC000910 mRNA Translation: AAH00910.1 BC012397 mRNA Translation: AAH12397.1 BC013001 mRNA Translation: AAH13001.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2546.1 [Q15435-1] CCDS63190.1 [Q15435-5] CCDS63192.1 [Q15435-3] CCDS63193.1 [Q15435-4] CCDS63194.1 [Q15435-2]
PIRⁱ	S68209
NCBI Reference Sequences More...RefSeqⁱ	NP_001269338.1, NM_001282409.1 [Q15435-2] NP_001269339.1, NM_001282410.1 [Q15435-3] NP_001269340.1, NM_001282411.1 [Q15435-4] NP_001269341.1, NM_001282412.1 NP_001269342.1, NM_001282413.1 NP_001269343.1, NM_001282414.1 [Q15435-5] NP_002703.1, NM_002712.2 [Q15435-1]
UniGeneⁱ	Hs.36587

Genome annotation databases

Ensemblⁱ	ENST00000234038; ENSP00000234038; ENSG00000115685 [Q15435-1] ENST00000272983; ENSP00000272983; ENSG00000115685 [Q15435-2] ENST00000401987; ENSP00000385466; ENSG00000115685 [Q15435-4] ENST00000402734; ENSP00000385012; ENSG00000115685 [Q15435-5] ENST00000406106; ENSP00000385022; ENSG00000115685 [Q15435-3] ENST00000407025; ENSP00000385657; ENSG00000115685 [Q15435-1]
GeneIDⁱ	5510
KEGGⁱ	hsa:5510
UCSC genome browser More...UCSCⁱ	uc002was.5 human [Q15435-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15435	Uncharacterized protein		PANPA		376	UniRef100_Q15435
Protein phosphatase 1 regulatory subunit 7		GORGO		376
Protein phosphatase 1, regulatory subunit 7, isoform CRA_b		HUMAN		360
Uncharacterized protein		PANPA		360
Protein phosphatase 1 regulatory subunit 7		GORGO		360
+1
Q15435-2	Uncharacterized protein		PANPA		317	UniRef100_A0A2R9BXV0
Uncharacterized protein		NOMLE		317
Protein phosphatase 1 regulatory subunit 7		GORGO		317
Q15435-3	Uncharacterized protein		PANPA		280	UniRef100_A0A2R9BXV9
Protein phosphatase 1 regulatory subunit 7		GORGO		280

Protein	Similar proteins		Species	Score	Length	Source
Q15435	Protein phosphatase 1 regulatory subunit 7		BOVIN		360	UniRef90_Q15435
Protein phosphatase 1 regulatory subunit 7		PONAB		360
Protein phosphatase 1 regulatory subunit 7		RAT		360
Uncharacterized protein		PANPA		376
Protein phosphatase 1 regulatory subunit 7		GORGO		376
+193
Q15435-2	Uncharacterized protein		MACMU		317	UniRef90_F7GK00
Uncharacterized protein		COLAP		317
Uncharacterized protein		RHIRO		317
Uncharacterized protein		PAPAN		317
Uncharacterized protein		MACFA		317
+34
Q15435-3	Protein phosphatase 1 regulatory subunit 7		HORSE		286	UniRef90_F7AYA6
PPP1R7 isoform 1 (Fragment)		PONAB		282
Uncharacterized protein		MACMU		281
PPP1R7 isoform 10		PANTR		280
Uncharacterized protein		COLAP		280
+26
Q15435-4	Uncharacterized protein		AOTNA		280	UniRef90_Q15435-4
PPP1R7 isoform 13		PANTR		237
PPP1R7 isoform 13		PONAB		237
Protein phosphatase 1 regulatory subunit 7		FELCA		233
UPI0005335083		RHIRO		252
+2
Q15435-5	Protein phosphatase 1 regulatory subunit 7		CALJA		221	UniRef90_Q15435-5
PPP1R7 isoform 2		PONAB		221
PPP1R7 isoform 2		PANTR		221
Uncharacterized protein		PAPAN		221
Uncharacterized protein		MACNE		221
+3

Protein	Similar proteins		Species	Score	Length	Source
Q15435	Protein phosphatase 1 regulatory subunit 7		BOVIN		360	UniRef50_Q15435
Protein phosphatase 1 regulatory subunit 7		PONAB		360
Protein phosphatase 1 regulatory subunit 7		RAT		360
Protein phosphatase 1 regulatory subunit 7		MOUSE		361
Protein phosphatase 1 regulatory subunit 7		XENTR		346
+436
Q15435-2	GH07711p		DROME		326	UniRef50_Q9VEK8
protein phosphatase 1 regulatory subunit 7		DROFC		326
GD19152		DROSI		326
GM15226		DROSE		326
Sds22, isoform A		DROYA		326
+260
Q15435-3	Isoform 4 of Protein phosphatase 1 regulatory subunit 7		HUMAN		237	UniRef50_Q15435-4
Uncharacterized protein		AOTNA		280
PPP1R7 isoform 13		PONAB		237
PPP1R7 isoform 13		PANTR		237
Protein phosphatase 1 regulatory subunit 7		FELCA		233
+103
Q15435-4	Uncharacterized protein		AOTNA		280	UniRef50_Q15435-4
PPP1R7 isoform 13		PONAB		237
PPP1R7 isoform 13		PANTR		237
Protein phosphatase 1 regulatory subunit 7		FELCA		233
Protein phosphatase 1 regulatory subunit 7		FUNHE		334
+103
Q15435-5	PPP1R7 isoform 2		PONAB		221	UniRef50_Q15435-5
Protein phosphatase 1 regulatory subunit 7		CALJA		221
PPP1R7 isoform 2		PANTR		221
Uncharacterized protein		RHIBE		221
Uncharacterized protein		PAPAN		221
+6

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z50749 mRNA Translation: CAA90626.1 AF067136 AF067135 Genomic DNA Translation: AAD26610.1 AF067136 AF067131 Genomic DNA Translation: AAD26611.1 AF067134 AF067133 Genomic DNA Translation: AAD26612.1 AF067134 , AF067132, AF067130, AF067133 Genomic DNA Translation: AAD26613.1 BT007296 mRNA Translation: AAP35960.1 BT020134 mRNA Translation: AAV38936.1 AK294043 mRNA Translation: BAG57395.1 AC005237 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW71243.1 BC000910 mRNA Translation: AAH00910.1 BC012397 mRNA Translation: AAH12397.1 BC013001 mRNA Translation: AAH13001.1
CCDSⁱ	CCDS2546.1 [Q15435-1] CCDS63190.1 [Q15435-5] CCDS63192.1 [Q15435-3] CCDS63193.1 [Q15435-4] CCDS63194.1 [Q15435-2]
PIRⁱ	S68209
RefSeqⁱ	NP_001269338.1, NM_001282409.1 [Q15435-2] NP_001269339.1, NM_001282410.1 [Q15435-3] NP_001269340.1, NM_001282411.1 [Q15435-4] NP_001269341.1, NM_001282412.1 NP_001269342.1, NM_001282413.1 NP_001269343.1, NM_001282414.1 [Q15435-5] NP_002703.1, NM_002712.2 [Q15435-1]
UniGeneⁱ	Hs.36587

3D structure databases

ProteinModelPortalⁱ	Q15435
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111502, 60 interactors
DIPⁱ	DIP-1005N
IntActⁱ	Q15435, 43 interactors
MINTⁱ	Q15435
STRINGⁱ	9606.ENSP00000234038

PTM databases

iPTMnetⁱ	Q15435
PhosphoSitePlusⁱ	Q15435

Polymorphism and mutation databases

DMDMⁱ	74762145

DMDMⁱ

74762145

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00033600

REPRODUCTION-2DPAGEⁱ

IPI00033600

Proteomic databases

EPDⁱ	Q15435
MaxQBⁱ	Q15435
PaxDbⁱ	Q15435
PeptideAtlasⁱ	Q15435
PRIDEⁱ	Q15435
ProteomicsDBⁱ	60591 60592 [Q15435-2] 60593 [Q15435-3] 60594 [Q15435-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5510
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000234038; ENSP00000234038; ENSG00000115685 [Q15435-1] ENST00000272983; ENSP00000272983; ENSG00000115685 [Q15435-2] ENST00000401987; ENSP00000385466; ENSG00000115685 [Q15435-4] ENST00000402734; ENSP00000385012; ENSG00000115685 [Q15435-5] ENST00000406106; ENSP00000385022; ENSG00000115685 [Q15435-3] ENST00000407025; ENSP00000385657; ENSG00000115685 [Q15435-1]
GeneIDⁱ	5510
KEGGⁱ	hsa:5510
UCSCⁱ	uc002was.5 human [Q15435-1]

Organism-specific databases

CTDⁱ	5510
DisGeNETⁱ	5510
EuPathDBⁱ	HostDB:ENSG00000115685.14
GeneCardsⁱ	PPP1R7
HGNCⁱ	HGNC:9295 PPP1R7
HPAⁱ	HPA034500 HPA034501
MIMⁱ	602877 gene
neXtProtⁱ	NX_Q15435
OpenTargetsⁱ	ENSG00000115685
PharmGKBⁱ	PA33658
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0531 Eukaryota COG4886 LUCA
GeneTreeⁱ	ENSGT00930000150857
HOGENOMⁱ	HOG000211189
HOVERGENⁱ	HBG082161
InParanoidⁱ	Q15435
KOⁱ	K17550
OMAⁱ	LFLRWNL
OrthoDBⁱ	EOG091G0FWO
PhylomeDBⁱ	Q15435
TreeFamⁱ	TF105538

Miscellaneous databases

ChiTaRSⁱ	PPP1R7 human
GeneWikiⁱ	PPP1R7
GenomeRNAiⁱ	5510
Protein Ontology More...PROⁱ	PR:Q15435
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000115685 Expressed in 233 organ(s), highest expression level in testis
CleanExⁱ	HS_PPP1R7
ExpressionAtlasⁱ	Q15435 baseline and differential
Genevisibleⁱ	Q15435 HS

Family and domain databases

Gene3Dⁱ	3.80.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR003603 U2A'_phosphoprotein32A_C
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 7 hits SM00446 LRRcap, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 12 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PP1R7_HUMAN
Accessionⁱ	Q15435Primary (citable) accession number: Q15435 Secondary accession number(s): B4DFD4 , B5MCY6, Q9UQE5, Q9UQE6, Q9Y6K4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q15435 (PP1R7_HUMAN)

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Protein phosphatase 1 regulatory subunit 7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

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Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

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Keywords - Technical termⁱ