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UniProtKB - Q15435 (PP1R7_HUMAN)
Protein
Protein phosphatase 1 regulatory subunit 7
Gene
PPP1R7
Organism
Homo sapiens (Human)
Status
Functioni
Regulatory subunit of protein phosphatase 1.
By similarityGO - Molecular functioni
- enzyme regulator activity Source: UniProtKB
- protein phosphatase regulator activity Source: ProtInc
GO - Biological processi
- positive regulation of protein dephosphorylation Source: MGI
Enzyme and pathway databases
PathwayCommonsi | Q15435 |
SignaLinki | Q15435 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase 1 regulatory subunit 7Alternative name(s): Protein phosphatase 1 regulatory subunit 22 |
Gene namesi | Name:PPP1R7 Synonyms:SDS22 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9295, PPP1R7 |
MIMi | 602877, gene |
neXtProti | NX_Q15435 |
VEuPathDBi | HostDB:ENSG00000115685 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- chromosome Source: MGI
- cytoplasm Source: ProtInc
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 148 | D → V: Completely abolishes the interaction with protein phosphatase 1. 1 Publication | 1 | |
Mutagenesisi | 170 | F → A: Severely impaired the binding of protein phosphatase 1. 1 Publication | 1 | |
Mutagenesisi | 192 | E → A: Completely abolishes the interaction with protein phosphatase 1. 1 Publication | 1 | |
Mutagenesisi | 214 | F → A: Completely abolishes the interaction with protein phosphatase 1. 1 Publication | 1 | |
Mutagenesisi | 280 | D → A: Severely impairs the binding of protein phosphatase 1. 1 Publication | 1 | |
Mutagenesisi | 300 | E → A: Completely abolishes the interaction with protein phosphatase 1. 1 Publication | 1 | |
Mutagenesisi | 302 | W → A: Completely abolishes the interaction with protein phosphatase 1. 1 Publication | 1 | |
Mutagenesisi | 327 | Y → A: Completely abolishes the interaction with protein phosphatase 1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5510 |
OpenTargetsi | ENSG00000115685 |
PharmGKBi | PA33658 |
Miscellaneous databases
Pharosi | Q15435, Tbio |
Genetic variation databases
BioMutai | PPP1R7 |
DMDMi | 74762145 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000239613 | 2 – 360 | Protein phosphatase 1 regulatory subunit 7Add BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 12 | PhosphoserineCombined sources | 1 | |
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Modified residuei | 27 | PhosphoserineCombined sources | 1 | |
Modified residuei | 44 | PhosphoserineCombined sources | 1 | |
Modified residuei | 47 | PhosphoserineCombined sources | 1 | |
Modified residuei | 322 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q15435 |
jPOSTi | Q15435 |
MassIVEi | Q15435 |
MaxQBi | Q15435 |
PaxDbi | Q15435 |
PeptideAtlasi | Q15435 |
PRIDEi | Q15435 |
ProteomicsDBi | 60591 [Q15435-1] 60592 [Q15435-2] 60593 [Q15435-3] 60594 [Q15435-4] 6128 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00033600 |
PTM databases
iPTMneti | Q15435 |
MetOSitei | Q15435 |
PhosphoSitePlusi | Q15435 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000115685, Expressed in testis and 248 other tissues |
ExpressionAtlasi | Q15435, baseline and differential |
Genevisiblei | Q15435, HS |
Organism-specific databases
HPAi | ENSG00000115685, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G isoform 1.
1 PublicationBinary interactionsi
Q15435
With | #Exp. | IntAct |
---|---|---|
PPP1CA [P62136] | 7 | EBI-1024281,EBI-357253 |
PPP1CB [P62140] | 10 | EBI-1024281,EBI-352350 |
PPP1CC [P36873] | 5 | EBI-1024281,EBI-356283 |
USHBP1 [Q8N6Y0] | 3 | EBI-1024281,EBI-739895 |
Isoform 3 [Q15435-3]
With | #Exp. | IntAct |
---|---|---|
HRAS [P01112] | 3 | EBI-10695066,EBI-350145 |
Protein-protein interaction databases
BioGRIDi | 111502, 76 interactors |
DIPi | DIP-1005N |
IntActi | Q15435, 50 interactors |
MINTi | Q15435 |
STRINGi | 9606.ENSP00000234038 |
Miscellaneous databases
RNActi | Q15435, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q15435 |
SMRi | Q15435 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 77 – 98 | LRR 1Add BLAST | 22 | |
Repeati | 99 – 120 | LRR 2Add BLAST | 22 | |
Repeati | 121 – 142 | LRR 3Add BLAST | 22 | |
Repeati | 143 – 164 | LRR 4Add BLAST | 22 | |
Repeati | 165 – 186 | LRR 5Add BLAST | 22 | |
Repeati | 187 – 208 | LRR 6Add BLAST | 22 | |
Repeati | 209 – 230 | LRR 7Add BLAST | 22 | |
Repeati | 231 – 252 | LRR 8Add BLAST | 22 | |
Repeati | 253 – 274 | LRR 9Add BLAST | 22 | |
Repeati | 275 – 296 | LRR 10Add BLAST | 22 | |
Repeati | 297 – 318 | LRR 11Add BLAST | 22 | |
Domaini | 331 – 360 | LRRCTAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 64 | DisorderedSequence analysisAdd BLAST | 64 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 15 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 16 – 38 | Basic and acidic residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the SDS22 family.Curated
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0531, Eukaryota |
GeneTreei | ENSGT00940000158551 |
InParanoidi | Q15435 |
OMAi | YDNLIAH |
PhylomeDBi | Q15435 |
TreeFami | TF105538 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR003603, U2A'_phosphoprotein32A_C |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00446, LRRcap, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 12 hits |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q15435-1) [UniParc]FASTAAdd to basket
Also known as: sds22alpha1
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHSSGIV ADLSEQSLKD
60 70 80 90 100
GEERGEEDPE EEHELPVDME TINLDRDAED VDLNHYRIGK IEGFEVLKKV
110 120 130 140 150
KTLCLRQNLI KCIENLEELQ SLRELDLYDN QIKKIENLEA LTELEILDIS
160 170 180 190 200
FNLLRNIEGV DKLTRLKKLF LVNNKISKIE NLSNLHQLQM LELGSNRIRA
210 220 230 240 250
IENIDTLTNL ESLFLGKNKI TKLQNLDALT NLTVLSMQSN RLTKIEGLQN
260 270 280 290 300
LVNLRELYLS HNGIEVIEGL ENNNKLTMLD IASNRIKKIE NISHLTELQE
310 320 330 340 350
FWMNDNLLES WSDLDELKGA RSLETVYLER NPLQKDPQYR RKVMLALPSV
360
RQIDATFVRF
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C118 | H7C118_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R7 | 140 | Annotation score: | ||
B5MBZ8 | B5MBZ8_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R7 | 274 | Annotation score: | ||
C9JD73 | C9JD73_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R7 | 282 | Annotation score: | ||
C9JRC4 | C9JRC4_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R7 | 184 | Annotation score: | ||
H7C003 | H7C003_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R7 | 335 | Annotation score: | ||
C9J177 | C9J177_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R7 | 289 | Annotation score: | ||
H7C3Q5 | H7C3Q5_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R7 | 108 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055672 | 1 – 60 | MAAER…EEDPE → M in isoform 5. CuratedAdd BLAST | 60 | |
Alternative sequenceiVSP_019244 | 18 – 60 | Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_019245 | 274 – 280 | NKLTMLD → VQDSLTY in isoform 3, isoform 4 and isoform 5. 2 Publications | 7 | |
Alternative sequenceiVSP_019246 | 281 – 360 | Missing in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST | 80 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000234038.11; ENSP00000234038.6; ENSG00000115685.15 ENST00000272983.12; ENSP00000272983.8; ENSG00000115685.15 [Q15435-2] ENST00000401987.5; ENSP00000385466.1; ENSG00000115685.15 [Q15435-4] ENST00000402734.5; ENSP00000385012.1; ENSG00000115685.15 [Q15435-5] ENST00000406106.7; ENSP00000385022.3; ENSG00000115685.15 [Q15435-3] ENST00000407025.5; ENSP00000385657.1; ENSG00000115685.15 |
GeneIDi | 5510 |
KEGGi | hsa:5510 |
MANE-Selecti | ENST00000234038.11; ENSP00000234038.6; NM_002712.3; NP_002703.1 |
UCSCi | uc002was.5, human [Q15435-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6HKW | X-ray | 3.09 | A/B/C/D/E | 1-360 | [»] | |
6MKY | X-ray | 2.90 | A/B | 100-360 | [»] | |
6OBN | X-ray | 2.70 | C/D | 56-360 | [»] | |
6OBP | X-ray | 2.70 | C | 56-360 | [»] | |
AlphaFoldDBi | Q15435 | |||||
SMRi | Q15435 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111502, 76 interactors |
DIPi | DIP-1005N |
IntActi | Q15435, 50 interactors |
MINTi | Q15435 |
STRINGi | 9606.ENSP00000234038 |
PTM databases
iPTMneti | Q15435 |
MetOSitei | Q15435 |
PhosphoSitePlusi | Q15435 |
Genetic variation databases
BioMutai | PPP1R7 |
DMDMi | 74762145 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00033600 |
Proteomic databases
EPDi | Q15435 |
jPOSTi | Q15435 |
MassIVEi | Q15435 |
MaxQBi | Q15435 |
PaxDbi | Q15435 |
PeptideAtlasi | Q15435 |
PRIDEi | Q15435 |
ProteomicsDBi | 60591 [Q15435-1] 60592 [Q15435-2] 60593 [Q15435-3] 60594 [Q15435-4] 6128 |
Protocols and materials databases
Antibodypediai | 34547, 261 antibodies from 28 providers |
DNASUi | 5510 |
Genome annotation databases
Organism-specific databases
CTDi | 5510 |
DisGeNETi | 5510 |
GeneCardsi | PPP1R7 |
HGNCi | HGNC:9295, PPP1R7 |
HPAi | ENSG00000115685, Low tissue specificity |
MIMi | 602877, gene |
neXtProti | NX_Q15435 |
OpenTargetsi | ENSG00000115685 |
PharmGKBi | PA33658 |
VEuPathDBi | HostDB:ENSG00000115685 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0531, Eukaryota |
GeneTreei | ENSGT00940000158551 |
InParanoidi | Q15435 |
OMAi | YDNLIAH |
PhylomeDBi | Q15435 |
TreeFami | TF105538 |
Enzyme and pathway databases
PathwayCommonsi | Q15435 |
SignaLinki | Q15435 |
Miscellaneous databases
BioGRID-ORCSi | 5510, 662 hits in 1088 CRISPR screens |
ChiTaRSi | PPP1R7, human |
GeneWikii | PPP1R7 |
GenomeRNAii | 5510 |
Pharosi | Q15435, Tbio |
PROi | PR:Q15435 |
RNActi | Q15435, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115685, Expressed in testis and 248 other tissues |
ExpressionAtlasi | Q15435, baseline and differential |
Genevisiblei | Q15435, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR003603, U2A'_phosphoprotein32A_C |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00446, LRRcap, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 12 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PP1R7_HUMAN | |
Accessioni | Q15435Primary (citable) accession number: Q15435 Secondary accession number(s): B4DFD4 Q9Y6K4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 194 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families