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Entry version 148 (16 Oct 2019)
Sequence version 2 (14 Oct 2008)
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Protein

Synaptonemal complex protein 1

Gene

SYCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Meiosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1221632 Meiotic synapsis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptonemal complex protein 11 Publication
Short name:
SCP-1
Alternative name(s):
Cancer/testis antigen 8
Short name:
CT8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYCP11 PublicationImported
Synonyms:SCP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11487 SYCP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602162 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15431

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi101 – 111Missing : Impairs self-assembly of N-terminal ends. 1 PublicationAdd BLAST11
Mutagenesisi105V → E: Impairs self-assembly of N-terminal ends; when associated with E-109. 1 Publication1
Mutagenesisi109L → E: Impairs self-assembly of N-terminal ends; when associated with E-105. 1 Publication1
Mutagenesisi679L → A: Impairs pH-induced C-terminal tetrameric self-assembly; when associated with A-688. 1 Publication1
Mutagenesisi688I → A: Impairs pH-induced C-terminal tetrameric self-assembly; when associated with A-679. 1 Publication1
Mutagenesisi717H → E: Impairs pH-induced C-terminal tetrameric self-assembly. 1 Publication1
Mutagenesisi717H → W: Enables C-terminal tetrameric self-assembly at pH 8.0; when associated with F-721. 1 Publication1
Mutagenesisi721Y → F: Enables C-terminal tetrameric self-assembly at pH 8.0; when associated with W-717. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6847

Open Targets

More...
OpenTargetsi
ENSG00000198765

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36269

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15431

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SYCP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572682

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000723621 – 976Synaptonemal complex protein 1Add BLAST976

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15431

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15431

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q15431

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15431

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15431

PeptideAtlas

More...
PeptideAtlasi
Q15431

PRoteomics IDEntifications database

More...
PRIDEi
Q15431

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60589

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15431

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15431

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15431

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000198765 Expressed in 54 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15431 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15431 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021083

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Structural component of synaptonemal complexes (By similarity). Homotetramer that consists of an N-terminal four-helical bundle that bifurcates into two elongated C-terminal dimeric coiled coils (PubMed:29915389, PubMed:26323297). This tetrameric building block potentially self-assembles into a supramolecular zipper-like lattice to mediate meiotic chromosome synapsis. Self-assembly is likely initiated by local proton density at chromosome axis, which is predicted to trigger antiparallel back to back assembly of adjacent C-terminal ends into tetrameric structures that anchor to chromosomal DNA. Then the N-terminal ends are predicted to undergo cooperative antiparallel head to head assembly at the midline of synaptonemal complexes central element to form a zipper-like lattice between properly aligned homologous chromosomes (PubMed:29915389). The nascent synapsis generated by SYCP1 is stabilized through interaction with central element proteins SYCE1 and SYCE2 (By similarity).

Forms a complex with EWSR1, PRDM9, SYCP3 and REC8; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112714, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q15431, 4 interactors

Molecular INTeraction database

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MINTi
Q15431

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358535

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1976
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15431

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni676 – 770Required for pH-induced assembly of C-terminal ends into antiparallel tetramers1 PublicationAdd BLAST95
Regioni784 – 976DNA-binding1 PublicationAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili211 – 316Sequence analysisAdd BLAST106
Coiled coili391 – 439Sequence analysisAdd BLAST49
Coiled coili499 – 685Sequence analysisAdd BLAST187
Coiled coili739 – 798Sequence analysis1 PublicationAdd BLAST60

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi101 – 111Mediates head to head self-assembly of N-terminal ends1 PublicationAdd BLAST11
Motifi117 – 120Nuclear localization signalSequence analysis4
Motifi679 – 682Nuclear localization signalSequence analysis4
Motifi880 – 883Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 100Asp/Glu-rich (acidic)Add BLAST89
Compositional biasi961 – 969Arg/Lys-rich (basic)9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The molecule is in a coiled coil structure that is formed by 4 polypeptide chains. The N-terminal and C-terminal regions exhibit a prominent seven-residues periodicity.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH3F Eukaryota
ENOG410XZPD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003368

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154467

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15431

KEGG Orthology (KO)

More...
KOi
K19533

Identification of Orthologs from Complete Genome Data

More...
OMAi
LRCQHKI

Database of Orthologous Groups

More...
OrthoDBi
514396at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15431

TreeFam database of animal gene trees

More...
TreeFami
TF331737

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008827 SYCP1

The PANTHER Classification System

More...
PANTHERi
PTHR46918 PTHR46918, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05483 SCP-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q15431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKQKPFALF VPPRSSSSQV SAVKPQTLGG DSTFFKSFNK CTEDDFEFPF
60 70 80 90 100
AKTNLSKNGE NIDSDPALQK VNFLPVLEQV GNSDCHYQEG LKDSDLENSE
110 120 130 140 150
GLSRVYSKLY KEAEKIKKWK VSTEAELRQK ESKLQENRKI IEAQRKAIQE
160 170 180 190 200
LQFGNEKVSL KLEEGIQENK DLIKENNATR HLCNLLKETC ARSAEKTKKY
210 220 230 240 250
EYEREETRQV YMDLNNNIEK MITAFEELRV QAENSRLEMH FKLKEDYEKI
260 270 280 290 300
QHLEQEYKKE INDKEKQVSL LLIQITEKEN KMKDLTFLLE ESRDKVNQLE
310 320 330 340 350
EKTKLQSENL KQSIEKQHHL TKELEDIKVS LQRSVSTQKA LEEDLQIATK
360 370 380 390 400
TICQLTEEKE TQMEESNKAR AAHSFVVTEF ETTVCSLEEL LRTEQQRLEK
410 420 430 440 450
NEDQLKILTM ELQKKSSELE EMTKLTNNKE VELEELKKVL GEKETLLYEN
460 470 480 490 500
KQFEKIAEEL KGTEQELIGL LQAREKEVHD LEIQLTAITT SEQYYSKEVK
510 520 530 540 550
DLKTELENEK LKNTELTSHC NKLSLENKEL TQETSDMTLE LKNQQEDINN
560 570 580 590 600
NKKQEERMLK QIENLQETET QLRNELEYVR EELKQKRDEV KCKLDKSEEN
610 620 630 640 650
CNNLRKQVEN KNKYIEELQQ ENKALKKKGT AESKQLNVYE IKVNKLELEL
660 670 680 690 700
ESAKQKFGEI TDTYQKEIED KKISEENLLE EVEKAKVIAD EAVKLQKEID
710 720 730 740 750
KRCQHKIAEM VALMEKHKHQ YDKIIEERDS ELGLYKSKEQ EQSSLRASLE
760 770 780 790 800
IELSNLKAEL LSVKKQLEIE REEKEKLKRE AKENTATLKE KKDKKTQTFL
810 820 830 840 850
LETPEIYWKL DSKAVPSQTV SRNFTSVDHG ISKDKRDYLW TSAKNTLSTP
860 870 880 890 900
LPKAYTVKTP TKPKLQQREN LNIPIEESKK KRKMAFEFDI NSDSSETTDL
910 920 930 940 950
LSMVSEEETL KTLYRNNNPP ASHLCVKTPK KAPSSLTTPG STLKFGAIRK
960 970
MREDRWAVIA KMDRKKKLKE AEKLFV
Length:976
Mass (Da):114,192
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43058F1A4B7F57E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZC3A0A087WZC3_HUMAN
Synaptonemal complex protein 1
SYCP1
951Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VXJ5Q5VXJ5_HUMAN
Synaptonemal complex protein 1
SYCP1
792Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46F → L in CAA64956 (PubMed:9119375).Curated1
Sequence conflicti106Y → F in CAA64956 (PubMed:9119375).Curated1
Sequence conflicti153F → C in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti161K → T in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti168E → D in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti216N → S in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti225 – 226FE → HG in CAA64956 (PubMed:9119375).Curated2
Sequence conflicti350K → N in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti360E → D in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti400 – 401KN → NY in BAA22586 (PubMed:9371398).Curated2
Sequence conflicti406K → I in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti415K → T in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti449E → D in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti483 – 510IQLTA…LENEK → YSYCHYHKWTVLPKRGQRPK LSSKRE in BAA22586 (PubMed:9371398).CuratedAdd BLAST28
Sequence conflicti516 – 528LTSHC…SLENK → YFTLQQASPPPN in BAA22586 (PubMed:9371398).CuratedAdd BLAST13
Sequence conflicti549N → I in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti560K → T in BAA22586 (PubMed:9371398).Curated1
Sequence conflicti941S → P in CAA64956 (PubMed:9119375).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04699378E → D. Corresponds to variant dbSNP:rs12563933Ensembl.1
Natural variantiVAR_046994805E → D1 PublicationCorresponds to variant dbSNP:rs1053812Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X95654 mRNA Translation: CAA64956.1
D67035 mRNA Translation: BAA22586.1
AL645502 Genomic DNA No translation available.
AL358372 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56622.1
BC126266 mRNA Translation: AAI26267.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS879.1

NCBI Reference Sequences

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RefSeqi
NP_001269470.1, NM_001282541.1
NP_003167.2, NM_003176.3
XP_006710922.1, XM_006710859.1
XP_016857673.1, XM_017002184.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369518; ENSP00000358531; ENSG00000198765
ENST00000369522; ENSP00000358535; ENSG00000198765
ENST00000618516; ENSP00000480997; ENSG00000198765

Database of genes from NCBI RefSeq genomes

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GeneIDi
6847

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6847

UCSC genome browser

More...
UCSCi
uc001efq.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95654 mRNA Translation: CAA64956.1
D67035 mRNA Translation: BAA22586.1
AL645502 Genomic DNA No translation available.
AL358372 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56622.1
BC126266 mRNA Translation: AAI26267.1
CCDSiCCDS879.1
RefSeqiNP_001269470.1, NM_001282541.1
NP_003167.2, NM_003176.3
XP_006710922.1, XM_006710859.1
XP_016857673.1, XM_017002184.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YTOX-ray2.00A/B662-801[»]
6F5XX-ray1.91A101-175[»]
6F62X-ray2.07A/B101-206[»]
6F63X-ray2.15A/B/C/D676-770[»]
6F64X-ray2.49A676-770[»]
SMRiQ15431
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112714, 4 interactors
IntActiQ15431, 4 interactors
MINTiQ15431
STRINGi9606.ENSP00000358535

PTM databases

iPTMnetiQ15431
PhosphoSitePlusiQ15431
SwissPalmiQ15431

Polymorphism and mutation databases

BioMutaiSYCP1
DMDMi209572682

Proteomic databases

EPDiQ15431
jPOSTiQ15431
MassIVEiQ15431
MaxQBiQ15431
PaxDbiQ15431
PeptideAtlasiQ15431
PRIDEiQ15431
ProteomicsDBi60589

Genome annotation databases

EnsembliENST00000369518; ENSP00000358531; ENSG00000198765
ENST00000369522; ENSP00000358535; ENSG00000198765
ENST00000618516; ENSP00000480997; ENSG00000198765
GeneIDi6847
KEGGihsa:6847
UCSCiuc001efq.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6847
DisGeNETi6847

GeneCards: human genes, protein and diseases

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GeneCardsi
SYCP1
HGNCiHGNC:11487 SYCP1
HPAiHPA021083
MIMi602162 gene
neXtProtiNX_Q15431
OpenTargetsiENSG00000198765
PharmGKBiPA36269

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IH3F Eukaryota
ENOG410XZPD LUCA
GeneTreeiENSGT00390000003368
HOGENOMiHOG000154467
InParanoidiQ15431
KOiK19533
OMAiLRCQHKI
OrthoDBi514396at2759
PhylomeDBiQ15431
TreeFamiTF331737

Enzyme and pathway databases

ReactomeiR-HSA-1221632 Meiotic synapsis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SYCP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SYCP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6847
PharosiQ15431

Protein Ontology

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PROi
PR:Q15431

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000198765 Expressed in 54 organ(s), highest expression level in testis
ExpressionAtlasiQ15431 baseline and differential
GenevisibleiQ15431 HS

Family and domain databases

InterProiView protein in InterPro
IPR008827 SYCP1
PANTHERiPTHR46918 PTHR46918, 1 hit
PfamiView protein in Pfam
PF05483 SCP-1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYCP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15431
Secondary accession number(s): O14963, Q5VXJ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: October 16, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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