UniProtKB - Q15428 (SF3A2_HUMAN)
Splicing factor 3A subunit 2
SF3A2
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 54 – 84 | Matrin-typePROSITE-ProRule annotationAdd BLAST | 31 |
GO - Molecular functioni
- RNA binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- mRNA 3'-splice site recognition Source: HGNC-UCL
- mRNA processing Source: HGNC-UCL
- mRNA splicing, via spliceosome Source: UniProtKB
- positive regulation of neuron projection development Source: Ensembl
- spliceosomal complex assembly Source: GO_Central
- U2-type prespliceosome assembly Source: UniProtKB
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q15428 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Splicing factor 3A subunit 2Alternative name(s): SF3a662 Publications Spliceosome-associated protein 62 Short name: SAP 62 |
Gene namesi | Name:SF3A2 Synonyms:SAP62 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10766, SF3A2 |
MIMi | 600796, gene |
neXtProti | NX_Q15428 |
VEuPathDBi | HostDB:ENSG00000104897.9 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation5 Publications
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- nuclear speck Source: Ensembl
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- spliceosomal complex Source: HGNC-UCL
- U2 snRNP Source: UniProtKB
- U2-type precatalytic spliceosome Source: UniProtKB
- U2-type prespliceosome Source: GO_Central
Keywords - Cellular componenti
Nucleus, SpliceosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 8175 |
OpenTargetsi | ENSG00000104897 |
PharmGKBi | PA35684 |
Miscellaneous databases
Pharosi | Q15428, Tbio |
Chemistry databases
DrugBanki | DB09130, Copper |
Genetic variation databases
BioMutai | SF3A2 |
DMDMi | 20141793 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000174315 | 1 – 464 | Splicing factor 3A subunit 2Add BLAST | 464 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Modified residuei | 10 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 153 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q15428 |
jPOSTi | Q15428 |
MassIVEi | Q15428 |
MaxQBi | Q15428 |
PaxDbi | Q15428 |
PeptideAtlasi | Q15428 |
PRIDEi | Q15428 |
ProteomicsDBi | 60588 |
PTM databases
iPTMneti | Q15428 |
PhosphoSitePlusi | Q15428 |
SwissPalmi | Q15428 |
Expressioni
Gene expression databases
Bgeei | ENSG00000104897, Expressed in right ovary and 212 other tissues |
ExpressionAtlasi | Q15428, baseline and differential |
Genevisiblei | Q15428, HS |
Organism-specific databases
HPAi | ENSG00000104897, Low tissue specificity |
Interactioni
Subunit structurei
Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114 (PubMed:10882114, PubMed:11533230, PubMed:21349847). SF3A1 functions as scaffold that interacts directly with both SF3A2 and SF3A3 (PubMed:11533230, PubMed:21349847). SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP) (PubMed:10882114, PubMed:11533230). Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex (PubMed:10882114). Identified in the spliceosome 'A' and 'B' complexes (PubMed:10882114, PubMed:29361316, PubMed:29360106, PubMed:30315277). Identified in the spliceosome 'C' complex (PubMed:11991638).
Interacts with HTATSF1 (PubMed:9710584).
8 PublicationsBinary interactionsi
Hide detailsQ15428
Protein-protein interaction databases
BioGRIDi | 113826, 186 interactors |
CORUMi | Q15428 |
DIPi | DIP-42521N |
IntActi | Q15428, 139 interactors |
MINTi | Q15428 |
STRINGi | 9606.ENSP00000221494 |
Miscellaneous databases
RNActi | Q15428, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q15428 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 217 – 462 | Pro-richAdd BLAST | 246 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 54 – 84 | Matrin-typePROSITE-ProRule annotationAdd BLAST | 31 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0227, Eukaryota |
GeneTreei | ENSGT00720000108823 |
HOGENOMi | CLU_050757_1_1_1 |
InParanoidi | Q15428 |
OMAi | PPTPGVH |
OrthoDBi | 1320891at2759 |
PhylomeDBi | Q15428 |
TreeFami | TF314370 |
Family and domain databases
InterProi | View protein in InterPro IPR000690, Matrin/U1-C_Znf_C2H2 IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR031781, SF3A2_dom IPR036236, Znf_C2H2_sf |
Pfami | View protein in Pfam PF16835, SF3A2, 1 hit |
SMARTi | View protein in SMART SM00451, ZnF_U1, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50171, ZF_MATRIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MDFQHRPGGK TGSGGVASSS ESNRDRRERL RQLALETIDI NKDPYFMKNH
60 70 80 90 100
LGSYECKLCL TLHNNEGSYL AHTQGKKHQT NLARRAAKEA KEAPAQPAPE
110 120 130 140 150
KVKVEVKKFV KIGRPGYKVT KQRDSEMGQQ SLLFQIDYPE IAEGIMPRHR
160 170 180 190 200
FMSAYEQRIE PPDRRWQYLL MAAEPYETIA FKVPSREIDK AEGKFWTHWN
210 220 230 240 250
RETKQFFLQF HFKMEKPPAP PSLPAGPPGV KRPPPPLMNG LPPRPPLPES
260 270 280 290 300
LPPPPPGGLP LPPMPPTGPA PSGPPGPPQL PPPAPGVHPP APVVHPPASG
310 320 330 340 350
VHPPAPGVHP PAPGVHPPAP GVHPPTSGVH PPAPGVHPPA PGVHPPAPGV
360 370 380 390 400
HPPAPGVHPP APGVHPPPSA GVHPQAPGVH PAAPAVHPQA PGVHPPAPGM
410 420 430 440 450
HPQAPGVHPQ PPGVHPSAPG VHPQPPGVHP SNPGVHPPTP MPPMLRPPLP
460
SEGPGNIPPP PPTN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EMT0 | K7EMT0_HUMAN | Splicing factor 3A subunit 2 | SF3A2 | 135 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 29 | R → P in AAA60301 (PubMed:8211113).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L21990 Genomic DNA Translation: AAA60301.1 AK314815 mRNA Translation: BAG37338.1 AC005263 Genomic DNA Translation: AAC25613.1 CH471139 Genomic DNA Translation: EAW69398.1 CH471139 Genomic DNA Translation: EAW69400.1 CH471139 Genomic DNA Translation: EAW69401.1 CH471139 Genomic DNA Translation: EAW69402.1 BC004434 mRNA Translation: AAH04434.1 BC009903 mRNA Translation: AAH09903.1 |
CCDSi | CCDS12084.1 |
PIRi | A47655 |
RefSeqi | NP_009096.2, NM_007165.4 |
Genome annotation databases
Ensembli | ENST00000221494; ENSP00000221494; ENSG00000104897 |
GeneIDi | 8175 |
KEGGi | hsa:8175 |
UCSCi | uc002lvg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L21990 Genomic DNA Translation: AAA60301.1 AK314815 mRNA Translation: BAG37338.1 AC005263 Genomic DNA Translation: AAC25613.1 CH471139 Genomic DNA Translation: EAW69398.1 CH471139 Genomic DNA Translation: EAW69400.1 CH471139 Genomic DNA Translation: EAW69401.1 CH471139 Genomic DNA Translation: EAW69402.1 BC004434 mRNA Translation: AAH04434.1 BC009903 mRNA Translation: AAH09903.1 |
CCDSi | CCDS12084.1 |
PIRi | A47655 |
RefSeqi | NP_009096.2, NM_007165.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5Z56 | electron microscopy | 5.10 | v | 1-464 | [»] | |
5Z57 | electron microscopy | 6.50 | u | 88-369 | [»] | |
5Z58 | electron microscopy | 4.90 | u | 88-369 | [»] | |
6AH0 | electron microscopy | 5.70 | v | 1-464 | [»] | |
6AHD | electron microscopy | 3.80 | v | 1-464 | [»] | |
6FF4 | electron microscopy | 16.00 | 7 | 1-464 | [»] | |
6FF7 | electron microscopy | 4.50 | 7 | 1-464 | [»] | |
6QX9 | electron microscopy | 3.28 | A2 | 1-209 | [»] | |
6Y53 | electron microscopy | 7.10 | 7 | 1-464 | [»] | |
6Y5Q | electron microscopy | 7.10 | 7 | 1-464 | [»] | |
SMRi | Q15428 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113826, 186 interactors |
CORUMi | Q15428 |
DIPi | DIP-42521N |
IntActi | Q15428, 139 interactors |
MINTi | Q15428 |
STRINGi | 9606.ENSP00000221494 |
Chemistry databases
DrugBanki | DB09130, Copper |
PTM databases
iPTMneti | Q15428 |
PhosphoSitePlusi | Q15428 |
SwissPalmi | Q15428 |
Genetic variation databases
BioMutai | SF3A2 |
DMDMi | 20141793 |
Proteomic databases
EPDi | Q15428 |
jPOSTi | Q15428 |
MassIVEi | Q15428 |
MaxQBi | Q15428 |
PaxDbi | Q15428 |
PeptideAtlasi | Q15428 |
PRIDEi | Q15428 |
ProteomicsDBi | 60588 |
Protocols and materials databases
Antibodypediai | 22956, 163 antibodies |
DNASUi | 8175 |
Genome annotation databases
Ensembli | ENST00000221494; ENSP00000221494; ENSG00000104897 |
GeneIDi | 8175 |
KEGGi | hsa:8175 |
UCSCi | uc002lvg.4, human |
Organism-specific databases
CTDi | 8175 |
DisGeNETi | 8175 |
GeneCardsi | SF3A2 |
HGNCi | HGNC:10766, SF3A2 |
HPAi | ENSG00000104897, Low tissue specificity |
MIMi | 600796, gene |
neXtProti | NX_Q15428 |
OpenTargetsi | ENSG00000104897 |
PharmGKBi | PA35684 |
VEuPathDBi | HostDB:ENSG00000104897.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0227, Eukaryota |
GeneTreei | ENSGT00720000108823 |
HOGENOMi | CLU_050757_1_1_1 |
InParanoidi | Q15428 |
OMAi | PPTPGVH |
OrthoDBi | 1320891at2759 |
PhylomeDBi | Q15428 |
TreeFami | TF314370 |
Enzyme and pathway databases
PathwayCommonsi | Q15428 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 8175, 760 hits in 878 CRISPR screens |
ChiTaRSi | SF3A2, human |
GeneWikii | SF3A2 |
GenomeRNAii | 8175 |
Pharosi | Q15428, Tbio |
PROi | PR:Q15428 |
RNActi | Q15428, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104897, Expressed in right ovary and 212 other tissues |
ExpressionAtlasi | Q15428, baseline and differential |
Genevisiblei | Q15428, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000690, Matrin/U1-C_Znf_C2H2 IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR031781, SF3A2_dom IPR036236, Znf_C2H2_sf |
Pfami | View protein in Pfam PF16835, SF3A2, 1 hit |
SMARTi | View protein in SMART SM00451, ZnF_U1, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50171, ZF_MATRIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SF3A2_HUMAN | |
Accessioni | Q15428Primary (citable) accession number: Q15428 Secondary accession number(s): B2RBU1, D6W605, O75245 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 27, 2002 | |
Last modified: | February 10, 2021 | |
This is version 186 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families