UniProtKB - Q15428 (SF3A2_HUMAN)

BLAST

>sp|Q15428|SF3A2_HUMAN Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCL
TLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVT
KQRDSEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIA
FKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNG
LPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASG
VHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPP
APGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPG
VHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN

Align
Format
Add to basket Added to basket
History
Entry version 170 (07 Nov 2018)
Sequence version 2 (27 Mar 2002)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Splicing factor 3A subunit 2

Gene

SF3A2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	54 – 84	Matrin-typePROSITE-ProRule annotationAdd BLAST		31

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA 3'-splice site recognition
Source: HGNC
Traceable author statementⁱ
- 15647371
mRNA processing
Source: HGNC
Inferred from mutant phenotypeⁱ
- 15647371
mRNA splicing, via spliceosome Source: Reactome
positive regulation of neuron projection development Source: Ensembl
RNA splicing
Source: ProtInc
Traceable author statementⁱ
- 8211113
spliceosomal complex assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Splicing factor 3A subunit 2 Alternative name(s): SF3a66 Spliceosome-associated protein 62 Short name: SAP 62
Gene namesⁱ	Name:SF3A2 Synonyms:SAP62
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104897.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10766 SF3A2
MIMⁱ	600796 gene
neXtProtⁱ	NX_Q15428

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8175
Open Targets More...OpenTargetsⁱ	ENSG00000104897
PharmGKBⁱ	PA35684

Polymorphism and mutation databases

BioMutaⁱ	SF3A2
DMDMⁱ	20141793

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000174315	1 – 464	Splicing factor 3A subunit 2Add BLAST		464

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionine1 Publication	1
Modified residueⁱ	10	N6-acetyllysineBy similarity	1
Modified residueⁱ	153	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q15428
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15428
PaxDbⁱ	Q15428
PeptideAtlas More...PeptideAtlasⁱ	Q15428
PRIDEⁱ	Q15428
ProteomicsDBⁱ	60588

PTM databases

iPTMnetⁱ	Q15428
PhosphoSitePlusⁱ	Q15428

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000104897 Expressed in 198 organ(s), highest expression level in right ovary
CleanExⁱ	HS_SF3A2
ExpressionAtlasⁱ	Q15428 baseline and differential
Genevisibleⁱ	Q15428 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042843 HPA049439

HPAⁱ

HPA042843
HPA049439

Interactionⁱ

Subunit structureⁱ

Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Identified in the spliceosome C complex. Interacts with HTATSF1.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CDC5L	Q99459	2	EBI-2462271,EBI-374880
DHX15	O43143	2	EBI-2462271,EBI-1237044
SF1	Q15637	2	EBI-2462271,EBI-744603
SF3A1	Q15459	3	EBI-2462271,EBI-1054743

Protein-protein interaction databases

BioGridⁱ	113826, 153 interactors
CORUMⁱ	Q15428
Database of interacting proteins More...DIPⁱ	DIP-42521N
IntActⁱ	Q15428, 123 interactors
Molecular INTeraction database More...MINTⁱ	Q15428
STRINGⁱ	9606.ENSP00000221494

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15428
SMRⁱ	Q15428
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	217 – 462	Pro-richAdd BLAST		246

Sequence similaritiesⁱ

Belongs to the SF3A2 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	54 – 84	Matrin-typePROSITE-ProRule annotationAdd BLAST		31

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0227 Eukaryota COG5246 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00720000108823
HOVERGENⁱ	HBG060566
InParanoidⁱ	Q15428
KEGG Orthology (KO) More...KOⁱ	K12826
OMAⁱ	GIHPQAP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IZX
PhylomeDBⁱ	Q15428
TreeFamⁱ	TF314370

Family and domain databases

InterProⁱ	View protein in InterPro IPR000690 Matrin/U1-C_Znf_C2H2 IPR003604 Matrin/U1-like-C_Znf_C2H2 IPR031781 SF3A2_dom IPR036236 Znf_C2H2_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16835 SF3A2, 1 hit
SMARTⁱ	View protein in SMART SM00451 ZnF_U1, 1 hit
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50171 ZF_MATRIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q15428-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDFQHRPGGK TGSGGVASSS ESNRDRRERL RQLALETIDI NKDPYFMKNH 
        60         70         80         90        100
LGSYECKLCL TLHNNEGSYL AHTQGKKHQT NLARRAAKEA KEAPAQPAPE 
       110        120        130        140        150
KVKVEVKKFV KIGRPGYKVT KQRDSEMGQQ SLLFQIDYPE IAEGIMPRHR 
       160        170        180        190        200
FMSAYEQRIE PPDRRWQYLL MAAEPYETIA FKVPSREIDK AEGKFWTHWN 
       210        220        230        240        250
RETKQFFLQF HFKMEKPPAP PSLPAGPPGV KRPPPPLMNG LPPRPPLPES 
       260        270        280        290        300
LPPPPPGGLP LPPMPPTGPA PSGPPGPPQL PPPAPGVHPP APVVHPPASG 
       310        320        330        340        350
VHPPAPGVHP PAPGVHPPAP GVHPPTSGVH PPAPGVHPPA PGVHPPAPGV 
       360        370        380        390        400
HPPAPGVHPP APGVHPPPSA GVHPQAPGVH PAAPAVHPQA PGVHPPAPGM 
       410        420        430        440        450
HPQAPGVHPQ PPGVHPSAPG VHPQPPGVHP SNPGVHPPTP MPPMLRPPLP 
       460 
SEGPGNIPPP PPTN

Length:464

Mass (Da):49,256

Last modified:March 27, 2002 - v2

Checksum:ⁱFA46F064A55EA2CE

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	K7EMT0	K7EMT0_HUMAN		Splicing factor 3A subunit 2 Splicing factor 3A subunit 2	SF3A2	135	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	29	R → P in AAA60301 (PubMed:8211113).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L21990 Genomic DNA Translation: AAA60301.1 AK314815 mRNA Translation: BAG37338.1 AC005263 Genomic DNA Translation: AAC25613.1 CH471139 Genomic DNA Translation: EAW69398.1 CH471139 Genomic DNA Translation: EAW69400.1 CH471139 Genomic DNA Translation: EAW69401.1 CH471139 Genomic DNA Translation: EAW69402.1 BC004434 mRNA Translation: AAH04434.1 BC009903 mRNA Translation: AAH09903.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12084.1
PIRⁱ	A47655
NCBI Reference Sequences More...RefSeqⁱ	NP_009096.2, NM_007165.4
UniGeneⁱ	Hs.115232

Genome annotation databases

Ensemblⁱ	ENST00000221494; ENSP00000221494; ENSG00000104897
GeneIDⁱ	8175
KEGGⁱ	hsa:8175
UCSC genome browser More...UCSCⁱ	uc002lvg.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15428	SF3A2 isoform 1		PANTR		464	UniRef100_Q15428
Splicing factor 3a subunit 2		GORGO		464

Protein	Similar proteins		Species	Score	Length	Source
Q15428	Splicing factor 3A subunit 2		BOVIN		477	UniRef90_Q15428
Splicing factor 3A subunit 2		RAT		471
SF3A2 isoform 1		PANTR		464
Splicing factor 3a subunit 2		GORGO		464
Splicing factor 3a subunit 2		MONDO		494
+44

Protein	Similar proteins		Species	Score	Length	Source
Q15428	Splicing factor 3A subunit 2		BOVIN		477	UniRef50_Q15428
Splicing factor 3A subunit 2		RAT		471
SF3A2 isoform 1		PANTR		464
Splicing factor 3a subunit 2		GORGO		464
Splicing factor 3a subunit 2		MONDO		494
+59

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L21990 Genomic DNA Translation: AAA60301.1 AK314815 mRNA Translation: BAG37338.1 AC005263 Genomic DNA Translation: AAC25613.1 CH471139 Genomic DNA Translation: EAW69398.1 CH471139 Genomic DNA Translation: EAW69400.1 CH471139 Genomic DNA Translation: EAW69401.1 CH471139 Genomic DNA Translation: EAW69402.1 BC004434 mRNA Translation: AAH04434.1 BC009903 mRNA Translation: AAH09903.1
CCDSⁱ	CCDS12084.1
PIRⁱ	A47655
RefSeqⁱ	NP_009096.2, NM_007165.4
UniGeneⁱ	Hs.115232

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5Z56	electron microscopy	5.10	v	1-464	[»]
	5Z57	electron microscopy	6.50	u	88-369	[»]
	5Z58	electron microscopy	4.90	u	88-369	[»]
	6FF4	electron microscopy	16.00	7	1-464	[»]
ProteinModelPortalⁱ	Q15428
SMRⁱ	Q15428
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113826, 153 interactors
CORUMⁱ	Q15428
DIPⁱ	DIP-42521N
IntActⁱ	Q15428, 123 interactors
MINTⁱ	Q15428
STRINGⁱ	9606.ENSP00000221494

PTM databases

iPTMnetⁱ	Q15428
PhosphoSitePlusⁱ	Q15428

Polymorphism and mutation databases

BioMutaⁱ	SF3A2
DMDMⁱ	20141793

Proteomic databases

EPDⁱ	Q15428
MaxQBⁱ	Q15428
PaxDbⁱ	Q15428
PeptideAtlasⁱ	Q15428
PRIDEⁱ	Q15428
ProteomicsDBⁱ	60588

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8175
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000221494; ENSP00000221494; ENSG00000104897
GeneIDⁱ	8175
KEGGⁱ	hsa:8175
UCSCⁱ	uc002lvg.4 human

Organism-specific databases

CTDⁱ	8175
DisGeNETⁱ	8175
EuPathDBⁱ	HostDB:ENSG00000104897.9
GeneCardsⁱ	SF3A2
HGNCⁱ	HGNC:10766 SF3A2
HPAⁱ	HPA042843 HPA049439
MIMⁱ	600796 gene
neXtProtⁱ	NX_Q15428
OpenTargetsⁱ	ENSG00000104897
PharmGKBⁱ	PA35684
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0227 Eukaryota COG5246 LUCA
GeneTreeⁱ	ENSGT00720000108823
HOVERGENⁱ	HBG060566
InParanoidⁱ	Q15428
KOⁱ	K12826
OMAⁱ	GIHPQAP
OrthoDBⁱ	EOG091G0IZX
PhylomeDBⁱ	Q15428
TreeFamⁱ	TF314370

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSⁱ	SF3A2 human
GeneWikiⁱ	SF3A2
GenomeRNAiⁱ	8175
Protein Ontology More...PROⁱ	PR:Q15428
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104897 Expressed in 198 organ(s), highest expression level in right ovary
CleanExⁱ	HS_SF3A2
ExpressionAtlasⁱ	Q15428 baseline and differential
Genevisibleⁱ	Q15428 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000690 Matrin/U1-C_Znf_C2H2 IPR003604 Matrin/U1-like-C_Znf_C2H2 IPR031781 SF3A2_dom IPR036236 Znf_C2H2_sf
Pfamⁱ	View protein in Pfam PF16835 SF3A2, 1 hit
SMARTⁱ	View protein in SMART SM00451 ZnF_U1, 1 hit
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50171 ZF_MATRIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SF3A2_HUMAN
Accessionⁱ	Q15428Primary (citable) accession number: Q15428 Secondary accession number(s): B2RBU1, D6W605, O75245
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	March 27, 2002
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15428 (SF3A2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Splicing factor 3A subunit 2

SF3A2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ