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Protein

Splicing factor 3A subunit 2

Gene

SF3A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri54 – 84Matrin-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

  • mRNA 3'-splice site recognition Source: HGNC
  • mRNA processing Source: HGNC
  • mRNA splicing, via spliceosome Source: Reactome
  • positive regulation of neuron projection development Source: Ensembl
  • RNA splicing Source: ProtInc
  • spliceosomal complex assembly Source: GO_Central

Keywordsi

Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor 3A subunit 2
Alternative name(s):
SF3a66
Spliceosome-associated protein 62
Short name:
SAP 62
Gene namesi
Name:SF3A2
Synonyms:SAP62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104897.9
HGNCiHGNC:10766 SF3A2
MIMi600796 gene
neXtProtiNX_Q15428

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi8175
OpenTargetsiENSG00000104897
PharmGKBiPA35684

Polymorphism and mutation databases

BioMutaiSF3A2
DMDMi20141793

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001743151 – 464Splicing factor 3A subunit 2Add BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei10N6-acetyllysineBy similarity1
Modified residuei153PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ15428
MaxQBiQ15428
PaxDbiQ15428
PeptideAtlasiQ15428
PRIDEiQ15428
ProteomicsDBi60588

PTM databases

iPTMnetiQ15428
PhosphoSitePlusiQ15428

Expressioni

Gene expression databases

BgeeiENSG00000104897 Expressed in 198 organ(s), highest expression level in right ovary
CleanExiHS_SF3A2
ExpressionAtlasiQ15428 baseline and differential
GenevisibleiQ15428 HS

Organism-specific databases

HPAiHPA042843
HPA049439

Interactioni

Subunit structurei

Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Identified in the spliceosome C complex. Interacts with HTATSF1.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi113826, 153 interactors
CORUMiQ15428
DIPiDIP-42521N
IntActiQ15428, 123 interactors
MINTiQ15428
STRINGi9606.ENSP00000221494

Structurei

3D structure databases

ProteinModelPortaliQ15428
SMRiQ15428
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi217 – 462Pro-richAdd BLAST246

Sequence similaritiesi

Belongs to the SF3A2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri54 – 84Matrin-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0227 Eukaryota
COG5246 LUCA
GeneTreeiENSGT00720000108823
HOVERGENiHBG060566
InParanoidiQ15428
KOiK12826
OMAiGIHPQAP
OrthoDBiEOG091G0IZX
PhylomeDBiQ15428
TreeFamiTF314370

Family and domain databases

InterProiView protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR031781 SF3A2_dom
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF16835 SF3A2, 1 hit
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50171 ZF_MATRIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15428-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFQHRPGGK TGSGGVASSS ESNRDRRERL RQLALETIDI NKDPYFMKNH
60 70 80 90 100
LGSYECKLCL TLHNNEGSYL AHTQGKKHQT NLARRAAKEA KEAPAQPAPE
110 120 130 140 150
KVKVEVKKFV KIGRPGYKVT KQRDSEMGQQ SLLFQIDYPE IAEGIMPRHR
160 170 180 190 200
FMSAYEQRIE PPDRRWQYLL MAAEPYETIA FKVPSREIDK AEGKFWTHWN
210 220 230 240 250
RETKQFFLQF HFKMEKPPAP PSLPAGPPGV KRPPPPLMNG LPPRPPLPES
260 270 280 290 300
LPPPPPGGLP LPPMPPTGPA PSGPPGPPQL PPPAPGVHPP APVVHPPASG
310 320 330 340 350
VHPPAPGVHP PAPGVHPPAP GVHPPTSGVH PPAPGVHPPA PGVHPPAPGV
360 370 380 390 400
HPPAPGVHPP APGVHPPPSA GVHPQAPGVH PAAPAVHPQA PGVHPPAPGM
410 420 430 440 450
HPQAPGVHPQ PPGVHPSAPG VHPQPPGVHP SNPGVHPPTP MPPMLRPPLP
460
SEGPGNIPPP PPTN
Length:464
Mass (Da):49,256
Last modified:March 27, 2002 - v2
Checksum:iFA46F064A55EA2CE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMT0K7EMT0_HUMAN
Splicing factor 3A subunit 2
SF3A2
135Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29R → P in AAA60301 (PubMed:8211113).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21990 Genomic DNA Translation: AAA60301.1
AK314815 mRNA Translation: BAG37338.1
AC005263 Genomic DNA Translation: AAC25613.1
CH471139 Genomic DNA Translation: EAW69398.1
CH471139 Genomic DNA Translation: EAW69400.1
CH471139 Genomic DNA Translation: EAW69401.1
CH471139 Genomic DNA Translation: EAW69402.1
BC004434 mRNA Translation: AAH04434.1
BC009903 mRNA Translation: AAH09903.1
CCDSiCCDS12084.1
PIRiA47655
RefSeqiNP_009096.2, NM_007165.4
UniGeneiHs.115232

Genome annotation databases

EnsembliENST00000221494; ENSP00000221494; ENSG00000104897
GeneIDi8175
KEGGihsa:8175
UCSCiuc002lvg.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21990 Genomic DNA Translation: AAA60301.1
AK314815 mRNA Translation: BAG37338.1
AC005263 Genomic DNA Translation: AAC25613.1
CH471139 Genomic DNA Translation: EAW69398.1
CH471139 Genomic DNA Translation: EAW69400.1
CH471139 Genomic DNA Translation: EAW69401.1
CH471139 Genomic DNA Translation: EAW69402.1
BC004434 mRNA Translation: AAH04434.1
BC009903 mRNA Translation: AAH09903.1
CCDSiCCDS12084.1
PIRiA47655
RefSeqiNP_009096.2, NM_007165.4
UniGeneiHs.115232

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z56electron microscopy5.10v1-464[»]
5Z57electron microscopy6.50u88-369[»]
5Z58electron microscopy4.90u88-369[»]
6FF4electron microscopy16.0071-464[»]
ProteinModelPortaliQ15428
SMRiQ15428
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113826, 153 interactors
CORUMiQ15428
DIPiDIP-42521N
IntActiQ15428, 123 interactors
MINTiQ15428
STRINGi9606.ENSP00000221494

PTM databases

iPTMnetiQ15428
PhosphoSitePlusiQ15428

Polymorphism and mutation databases

BioMutaiSF3A2
DMDMi20141793

Proteomic databases

EPDiQ15428
MaxQBiQ15428
PaxDbiQ15428
PeptideAtlasiQ15428
PRIDEiQ15428
ProteomicsDBi60588

Protocols and materials databases

DNASUi8175
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221494; ENSP00000221494; ENSG00000104897
GeneIDi8175
KEGGihsa:8175
UCSCiuc002lvg.4 human

Organism-specific databases

CTDi8175
DisGeNETi8175
EuPathDBiHostDB:ENSG00000104897.9
GeneCardsiSF3A2
HGNCiHGNC:10766 SF3A2
HPAiHPA042843
HPA049439
MIMi600796 gene
neXtProtiNX_Q15428
OpenTargetsiENSG00000104897
PharmGKBiPA35684
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0227 Eukaryota
COG5246 LUCA
GeneTreeiENSGT00720000108823
HOVERGENiHBG060566
InParanoidiQ15428
KOiK12826
OMAiGIHPQAP
OrthoDBiEOG091G0IZX
PhylomeDBiQ15428
TreeFamiTF314370

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiSF3A2 human
GeneWikiiSF3A2
GenomeRNAii8175
PROiPR:Q15428
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104897 Expressed in 198 organ(s), highest expression level in right ovary
CleanExiHS_SF3A2
ExpressionAtlasiQ15428 baseline and differential
GenevisibleiQ15428 HS

Family and domain databases

InterProiView protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR031781 SF3A2_dom
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF16835 SF3A2, 1 hit
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50171 ZF_MATRIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSF3A2_HUMAN
AccessioniPrimary (citable) accession number: Q15428
Secondary accession number(s): B2RBU1, D6W605, O75245
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 27, 2002
Last modified: November 7, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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