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UniProtKB - Q15427 (SF3B4_HUMAN)

Entry version 215 (25 May 2022)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Splicing factor 3B subunit 4

Gene

SF3B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643).

SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).

May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114).

Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15427

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72165, mRNA Splicing - Minor Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15427

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Splicing factor 3B subunit 4
Alternative name(s):
Pre-mRNA-splicing factor SF3b 49 kDa subunit
Spliceosome-associated protein 49
Short name:
SAP 49
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SF3B4
Synonyms:SAP49
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10771, SF3B4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605593, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15427

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143368

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Acrofacial dysostosis 1, Nager type (AFD1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of acrofacial dysostosis, a group of disorders which are characterized by malformation of the craniofacial skeleton and the limbs. The major facial features of AFD1 include downslanted palpebral fissures, midface retrusion, and micrognathia, the latter of which often requires the placement of a tracheostomy in early childhood. Limb defects typically involve the anterior (radial) elements of the upper limbs and manifest as small or absent thumbs, triphalangeal thumbs, radial hyoplasia or aplasia, and radioulnar synostosis. Phocomelia of the upper limbs and, occasionally, lower-limb defects have also been reported.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		10262

MalaCards human disease database

More...MalaCardsi		SF3B4
MIMi154400, phenotype

Open Targets

More...OpenTargetsi		ENSG00000143368

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1788, Acrofacial dysostosis, Rodriguez type
245, Nager syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35689

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15427, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SF3B4

Domain mapping of disease mutations (DMDM)

More...DMDMi		2500587

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000819552 – 424Splicing factor 3B subunit 4Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei56PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15427

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15427

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15427

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15427

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15427

PeptideAtlas

More...PeptideAtlasi		Q15427

PRoteomics IDEntifications database

More...PRIDEi		Q15427

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60587

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q15427, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15427

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15427

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q15427

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143368, Expressed in mucosa of transverse colon and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15427, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15427, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143368, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A and DDX42 (PubMed:12234937, PubMed:12738865, PubMed:27720643, PubMed:28541300). SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP) (PubMed:12234937).

Interacts directly with SF3B2.

Found in a complex with PRMT9, SF3B2 and SF3B4 (PubMed:25737013). The SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and PHF5A interacts with U2AF2 (PubMed:27720643).

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q15427
With#Exp.IntAct
BAG3 [O95817]6EBI-348469,EBI-747185
BAIAP2 [Q9UQB8]3EBI-348469,EBI-525456
BCAS2 [O75934]2EBI-348469,EBI-1050106
CWF19L2 [Q2TBE0]6EBI-348469,EBI-5453285
EFTUD2 [Q15029]2EBI-348469,EBI-357897
FKBP1A [Q0VDC6]3EBI-348469,EBI-10226858
FRK [P42685]4EBI-348469,EBI-1383583
GRB2 [P62993]2EBI-348469,EBI-401755
HNRNPUL1 [Q9BUJ2]4EBI-348469,EBI-1018153
HSPB7 [Q9UBY9]3EBI-348469,EBI-739361
MAPK9 [P45984]7EBI-348469,EBI-713568
METTL17 [Q9H7H0]4EBI-348469,EBI-749353
NCK2 [O43639]7EBI-348469,EBI-713635
NUB1 [Q9Y5A7]3EBI-348469,EBI-3936907
PPP1R16B [Q96T49]4EBI-348469,EBI-10293968
PRMT9 [Q6P2P2]3EBI-348469,EBI-10962083
PRPF8 [Q6P2Q9]2EBI-348469,EBI-538479
QARS1 [P47897]3EBI-348469,EBI-347462
RAMAC [Q9BTL3]3EBI-348469,EBI-744023
RBM10 [P98175]8EBI-348469,EBI-721525
RBM39 [Q14498]3EBI-348469,EBI-395290
RPP25 [Q9BUL9]3EBI-348469,EBI-366570
SEC24D [O94855]3EBI-348469,EBI-748817
SF3B2 [E9PPJ0]3EBI-348469,EBI-10177154
SF3B2 [Q13435]8EBI-348469,EBI-749111
SS18L1 [O75177]4EBI-348469,EBI-744674
SS18L1 - isoform 5 [O75177-5]3EBI-348469,EBI-12035119
TCAF1 [Q9Y4C2]5EBI-348469,EBI-750484
TCAF1 - isoform 2 [Q9Y4C2-2]3EBI-348469,EBI-11974855
TFG [Q92734]3EBI-348469,EBI-357061
TLE5 - isoform 2 [Q08117-2]3EBI-348469,EBI-11741437
TRAF4 [Q9BUZ4]3EBI-348469,EBI-3650647
UBASH3A [P57075]3EBI-348469,EBI-2105393
WDR83 [Q9BRX9]2EBI-348469,EBI-7705033
ZCCHC10 [Q8TBK6]3EBI-348469,EBI-597063
ZNF3 [P17036]3EBI-348469,EBI-1640965
ZNF48 [Q96MX3]3EBI-348469,EBI-12006434
Proofreading exoribonuclease nsp14 (PRO_0000449631) from Severe acute respiratory syndrome coronavirus 2.3EBI-348469,EBI-25475920

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115554, 337 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2227, SF3B complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15427

Protein interaction database and analysis system

More...IntActi		Q15427, 88 interactors

Molecular INTeraction database

More...MINTi		Q15427

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000271628

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15427, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1424
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q15427

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15427

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15427

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 91RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini100 – 179RRM 2PROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni207 – 424DisorderedSequence analysisAdd BLAST218

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi232 – 274Pro residuesSequence analysisAdd BLAST43
Compositional biasi327 – 424Pro residuesSequence analysisAdd BLAST98

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SF3B4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0131, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00870000136537

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012062_21_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15427

Identification of Orthologs from Complete Genome Data

More...OMAi		HWEQNKE

Database of Orthologous Groups

More...OrthoDBi		1479417at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15427

TreeFam database of animal gene trees

More...TreeFami		TF300890

Family and domain databases

Conserved Domains Database

More...CDDi		cd12334, RRM1_SF3B4, 1 hit
cd12335, RRM2_SF3B4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034158, SF3B4_RRM1
IPR034159, SF3B4_RRM2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15427-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGPISERN QDATVYVGGL DEKVSEPLLW ELFLQAGPVV NTHMPKDRVT 
        60         70         80         90        100
GQHQGYGFVE FLSEEDADYA IKIMNMIKLY GKPIRVNKAS AHNKNLDVGA 
       110        120        130        140        150
NIFIGNLDPE IDEKLLYDTF SAFGVILQTP KIMRDPDTGN SKGYAFINFA 
       160        170        180        190        200
SFDASDAAIE AMNGQYLCNR PITVSYAFKK DSKGERHGSA AERLLAAQNP 
       210        220        230        240        250
LSQADRPHQL FADAPPPPSA PNPVVSSLGS GLPPPGMPPP GSFPPPVPPP 
       260        270        280        290        300
GALPPGIPPA MPPPPMPPGA AGHGPPSAGT PGAGHPGHGH SHPHPFPPGG 
       310        320        330        340        350
MPHPGMSQMQ LAHHGPHGLG HPHAGPPGSG GQPPPRPPPG MPHPGPPPMG 
       360        370        380        390        400
MPPRGPPFGS PMGHPGPMPP HGMRGPPPLM PPHGYTGPPR PPPYGYQRGP 
       410        420 
LPPPRPTPRP PVPPRGPLRG PLPQ
Length:424
Mass (Da):44,386
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i212472A25D3FF002
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SZ64Q5SZ64_HUMAN
Splicing factor 3B subunit 4
SF3B4 RP11-196G18.20-002
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L35013 Genomic DNA Translation: AAA60300.1
AL591493, AL590487 Genomic DNA Translation: CAI12554.1
AL590487, AL591493 Genomic DNA Translation: CAI12648.1
CH471121 Genomic DNA Translation: EAW53595.1
BC004273 mRNA Translation: AAH04273.1
BC013886 mRNA Translation: AAH13886.1
BC090883 mRNA Translation: AAH90883.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS72900.1

Protein sequence database of the Protein Information Resource

More...PIRi		A54964

NCBI Reference Sequences

More...RefSeqi		NP_005841.1, NM_005850.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000271628.9; ENSP00000271628.8; ENSG00000143368.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10262

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10262

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000271628.9; ENSP00000271628.8; NM_005850.5; NP_005841.1

UCSC genome browser

More...UCSCi		uc001etk.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35013 Genomic DNA Translation: AAA60300.1
AL591493, AL590487 Genomic DNA Translation: CAI12554.1
AL590487, AL591493 Genomic DNA Translation: CAI12648.1
CH471121 Genomic DNA Translation: EAW53595.1
BC004273 mRNA Translation: AAH04273.1
BC013886 mRNA Translation: AAH13886.1
BC090883 mRNA Translation: AAH90883.1
CCDSiCCDS72900.1
PIRiA54964
RefSeqiNP_005841.1, NM_005850.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5TNMR-A102-184[»]
5GVQNMR-A5-96[»]
5Z56electron microscopy5.1041-424[»]
5Z57electron microscopy6.5041-424[»]
5Z58electron microscopy4.9041-424[»]
6AH0electron microscopy5.7041-424[»]
6AHDelectron microscopy3.8041-424[»]
6QX9electron microscopy3.28B41-424[»]
6Y53electron microscopy7.10o1-424[»]
6Y5Qelectron microscopy7.10o1-424[»]
7ABGelectron microscopy7.80w1-424[»]
7ABHelectron microscopy4.50w1-424[»]
7ABIelectron microscopy8.00w1-424[»]
7DVQelectron microscopy2.8941-424[»]
7ONBelectron microscopy3.10K1-424[»]
AlphaFoldDBiQ15427
SMRiQ15427
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115554, 337 interactors
ComplexPortaliCPX-2227, SF3B complex
CORUMiQ15427
IntActiQ15427, 88 interactors
MINTiQ15427
STRINGi9606.ENSP00000271628

PTM databases

GlyGeniQ15427, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ15427
PhosphoSitePlusiQ15427
SwissPalmiQ15427

Genetic variation databases

BioMutaiSF3B4
DMDMi2500587

Proteomic databases

EPDiQ15427
jPOSTiQ15427
MassIVEiQ15427
MaxQBiQ15427
PaxDbiQ15427
PeptideAtlasiQ15427
PRIDEiQ15427
ProteomicsDBi60587

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20268, 332 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		10262

Genome annotation databases

EnsembliENST00000271628.9; ENSP00000271628.8; ENSG00000143368.10
GeneIDi10262
KEGGihsa:10262
MANE-SelectiENST00000271628.9; ENSP00000271628.8; NM_005850.5; NP_005841.1
UCSCiuc001etk.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10262
DisGeNETi10262

GeneCards: human genes, protein and diseases

More...GeneCardsi		SF3B4
HGNCiHGNC:10771, SF3B4
HPAiENSG00000143368, Low tissue specificity
MalaCardsiSF3B4
MIMi154400, phenotype
605593, gene
neXtProtiNX_Q15427
OpenTargetsiENSG00000143368
Orphaneti1788, Acrofacial dysostosis, Rodriguez type
245, Nager syndrome
PharmGKBiPA35689
VEuPathDBiHostDB:ENSG00000143368

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0131, Eukaryota
GeneTreeiENSGT00870000136537
HOGENOMiCLU_012062_21_0_1
InParanoidiQ15427
OMAiHWEQNKE
OrthoDBi1479417at2759
PhylomeDBiQ15427
TreeFamiTF300890

Enzyme and pathway databases

PathwayCommonsiQ15427
ReactomeiR-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72165, mRNA Splicing - Minor Pathway
SignaLinkiQ15427

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10262, 781 hits in 1081 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SF3B4, human
EvolutionaryTraceiQ15427

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SF3B4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10262
PharosiQ15427, Tbio

Protein Ontology

More...PROi		PR:Q15427
RNActiQ15427, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143368, Expressed in mucosa of transverse colon and 217 other tissues
ExpressionAtlasiQ15427, baseline and differential
GenevisibleiQ15427, HS

Family and domain databases

CDDicd12334, RRM1_SF3B4, 1 hit
cd12335, RRM2_SF3B4, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034158, SF3B4_RRM1
IPR034159, SF3B4_RRM2
PfamiView protein in Pfam
PF00076, RRM_1, 2 hits
SMARTiView protein in SMART
SM00360, RRM, 2 hits
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSF3B4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15427
Secondary accession number(s): Q5SZ63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 215 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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