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Entry version 187 (16 Oct 2019)
Sequence version 4 (17 Oct 2006)
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Protein

Scaffold attachment factor B1

Gene

SAFB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor, RNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3899300 SUMOylation of transcription cofactors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Scaffold attachment factor B1
Short name:
SAF-B
Short name:
SAF-B1
Alternative name(s):
HSP27 estrogen response element-TATA box-binding protein
Short name:
HSP27 ERE-TATA-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAFB
Synonyms:HAP, HET, SAFB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10520 SAFB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602895 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15424

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6294

Open Targets

More...
OpenTargetsi
ENSG00000160633

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34928

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15424

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SAFB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242782

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000819052 – 915Scaffold attachment factor B1Add BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei24PhosphoserineBy similarity1
Modified residuei55PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei188PhosphothreonineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei209PhosphoserineBy similarity1
Cross-linki231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei383PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Cross-linki392Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei415PhosphoserineCombined sources1
Cross-linki483Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki514Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki543Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki570Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki578Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki578Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei580PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei607N6-acetyllysineCombined sources1
Modified residuei811Omega-N-methylarginineCombined sources1
Cross-linki847Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei868Asymmetric dimethylarginineCombined sources1
Modified residuei874Asymmetric dimethylarginineCombined sources1
Modified residuei884Asymmetric dimethylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional repressor activity.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15424

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15424

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15424

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15424

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15424

PeptideAtlas

More...
PeptideAtlasi
Q15424

PRoteomics IDEntifications database

More...
PRIDEi
Q15424

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
25341
60586 [Q15424-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15424

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15424

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15424

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160633 Expressed in 232 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15424 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15424 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB001969
HPA016832
HPA020076

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Can form homodimers.

Interacts with KHDRBS3, POLR2A, SAFB2 or SFRS1, SFRS9 and TRA2B/SFRS10 (By similarity).

Interacts with isoform 1 and isoform 2 of SRPK1 and inhibits its activity.

Interacts with RBMX (By similarity).

Interacts with FUS.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112201, 113 interactors

Protein interaction database and analysis system

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IntActi
Q15424, 51 interactors

Molecular INTeraction database

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MINTi
Q15424

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000467423

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 65SAPPROSITE-ProRule annotationAdd BLAST35
Domaini406 – 484RRMPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni528 – 792Interaction with POLR2A1 PublicationAdd BLAST265
Regioni599 – 915Interaction with SAFB2Add BLAST317

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi599 – 616Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi612 – 831Arg-richAdd BLAST220
Compositional biasi625 – 705Glu-richAdd BLAST81
Compositional biasi785 – 903Gly-richAdd BLAST119

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4661 Eukaryota
ENOG4111F1G LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155916

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000092533

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15424

Identification of Orthologs from Complete Genome Data

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OMAi
PRDRRDW

Database of Orthologous Groups

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OrthoDBi
803886at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15424

TreeFam database of animal gene trees

More...
TreeFami
TF325240

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.720.30, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034781 SAFB1
IPR003034 SAP_dom
IPR036361 SAP_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15683:SF6 PTHR15683:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit
PF02037 SAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 1 hit
SM00513 SAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit
SSF68906 SSF68906, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit
PS50800 SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15424-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAETLSGLGD SGAAGAAALS SASSETGTRR LSDLRVIDLR AELRKRNVDS
60 70 80 90 100
SGNKSVLMER LKKAIEDEGG NPDEIEITSE GNKKTSKRSS KGRKPEEEGV
110 120 130 140 150
EDNGLEENSG DGQEDVETSL ENLQDIDIMD ISVLDEAEID NGSVADCVED
160 170 180 190 200
DDADNLQESL SDSRELVEGE MKELPEQLQE HAIEDKETIN NLDTSSSDFT
210 220 230 240 250
ILQEIEEPSL EPENEKILDI LGETCKSEPV KEESSELEQP FAQDTSSVGP
260 270 280 290 300
DRKLAEEEDL FDSAHPEEGD LDLASESTAH AQSSKADSLL AVVKREPAEQ
310 320 330 340 350
PGDGERTDCE PVGLEPAVEQ SSAASELAEA SSEELAEAPT EAPSPEARDS
360 370 380 390 400
KEDGRKFDFD ACNEVPPAPK ESSTSEGADQ KMSSPEDDSD TKRLSKEEKG
410 420 430 440 450
RSSCGRNFWV SGLSSTTRAT DLKNLFSKYG KVVGAKVVTN ARSPGARCYG
460 470 480 490 500
FVTMSTAEEA TKCINHLHKT ELHGKMISVE KAKNEPVGKK TSDKRDSDGK
510 520 530 540 550
KEKSSNSDRS TNLKRDDKCD RKDDAKKGDD GSGEKSKDQD DQKPGPSERS
560 570 580 590 600
RATKSGSRGT ERTVVMDKSK GVPVISVKTS GSKERASKSQ DRKSASREKR
610 620 630 640 650
SVVSFDKVKE PRKSRDSESH SRVRERSERE QRMQAQWERE ERERLEIARE
660 670 680 690 700
RLAFQRQRLE RERMERERLE RERMHVEHER RREQERIHRE REELRRQQEL
710 720 730 740 750
RYEQERRPAV RRPYDLDRRD DAYWPEAKRA ALDERYHSDF NRQDRFHDFD
760 770 780 790 800
HRDRGRYPDH SVDRREGSRS MMGEREGQHY PERHGGPERH GRDSRDGWGG
810 820 830 840 850
YGSDKRMSEG RGLPPPPRRD WGDHGRREDD RSWQGTADGG MMDRDHKRWQ
860 870 880 890 900
GGERSMSGHS GPGHMMNRGG MSGRGSFAPG GASRGHPIPH GGMQGGFGGQ
910
SRGSRPSDAR FTRRY
Length:915
Mass (Da):102,642
Last modified:October 17, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE865940BC7783C4A
GO
Isoform 2 (identifier: Q15424-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-182: Missing.
     817-817: P → PRG

Note: No experimental confirmation available.
Show »
Length:848
Mass (Da):95,181
Checksum:i681FC59B003DBAD5
GO
Isoform 3 (identifier: Q15424-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     817-817: P → PRG

Note: No experimental confirmation available.
Show »
Length:917
Mass (Da):102,855
Checksum:i9DB77C0D393EA6BB
GO
Isoform 4 (identifier: Q15424-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-621: Missing.
     817-817: P → PRG

Note: No experimental confirmation available.
Show »
Length:916
Mass (Da):102,768
Checksum:i6A3B946D0D5A0733
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES42K7ES42_HUMAN
Scaffold attachment factor B1
SAFB
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EII0K7EII0_HUMAN
Scaffold attachment factor B1
SAFB
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92017 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16A → P in AAC00056 (PubMed:9328833).Curated1
Sequence conflicti42 – 43EL → DV in AAC00056 (PubMed:9328833).Curated2
Sequence conflicti197S → P in BAH12852 (PubMed:14702039).Curated1
Sequence conflicti463C → Y in BAH12852 (PubMed:14702039).Curated1
Sequence conflicti692E → V in BAH12852 (PubMed:14702039).Curated1
Sequence conflicti731A → G in AAC00056 (PubMed:9328833).Curated1
Sequence conflicti731A → G in AAC18697 (PubMed:8600450).Curated1
Sequence conflicti744D → E in AAC00056 (PubMed:9328833).Curated1
Sequence conflicti744D → E in AAC18697 (PubMed:8600450).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045838114 – 182Missing in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_046902621Missing in isoform 4. 2 Publications1
Alternative sequenceiVSP_045839817P → PRG in isoform 2, isoform 3 and isoform 4. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U72355 mRNA Translation: AAC00056.1
AK298707 mRNA Translation: BAH12852.1
AC004611 Genomic DNA Translation: AAC14667.1
AC011499 Genomic DNA No translation available.
AC134303 Genomic DNA No translation available.
BC126219 mRNA Translation: AAI26220.1
BC143937 mRNA Translation: AAI43938.1
BC143939 mRNA Translation: AAI43940.1
AB208780 mRNA Translation: BAD92017.1 Different initiation.
L43631 mRNA Translation: AAC18697.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12142.1 [Q15424-1]
CCDS56077.1 [Q15424-2]
CCDS59339.1 [Q15424-3]
CCDS59340.1 [Q15424-4]

Protein sequence database of the Protein Information Resource

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PIRi
S64732

NCBI Reference Sequences

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RefSeqi
NP_001188267.1, NM_001201338.1 [Q15424-3]
NP_001188268.1, NM_001201339.1 [Q15424-4]
NP_001188269.1, NM_001201340.1 [Q15424-2]
NP_001307500.1, NM_001320571.1
NP_001307501.1, NM_001320572.1
NP_002958.2, NM_002967.3 [Q15424-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292123; ENSP00000292123; ENSG00000160633 [Q15424-1]
ENST00000454510; ENSP00000415895; ENSG00000160633 [Q15424-2]
ENST00000588852; ENSP00000467423; ENSG00000160633 [Q15424-3]
ENST00000592224; ENSP00000464840; ENSG00000160633 [Q15424-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6294

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6294

UCSC genome browser

More...
UCSCi
uc002mce.5 human [Q15424-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72355 mRNA Translation: AAC00056.1
AK298707 mRNA Translation: BAH12852.1
AC004611 Genomic DNA Translation: AAC14667.1
AC011499 Genomic DNA No translation available.
AC134303 Genomic DNA No translation available.
BC126219 mRNA Translation: AAI26220.1
BC143937 mRNA Translation: AAI43938.1
BC143939 mRNA Translation: AAI43940.1
AB208780 mRNA Translation: BAD92017.1 Different initiation.
L43631 mRNA Translation: AAC18697.1
CCDSiCCDS12142.1 [Q15424-1]
CCDS56077.1 [Q15424-2]
CCDS59339.1 [Q15424-3]
CCDS59340.1 [Q15424-4]
PIRiS64732
RefSeqiNP_001188267.1, NM_001201338.1 [Q15424-3]
NP_001188268.1, NM_001201339.1 [Q15424-4]
NP_001188269.1, NM_001201340.1 [Q15424-2]
NP_001307500.1, NM_001320571.1
NP_001307501.1, NM_001320572.1
NP_002958.2, NM_002967.3 [Q15424-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112201, 113 interactors
IntActiQ15424, 51 interactors
MINTiQ15424
STRINGi9606.ENSP00000467423

PTM databases

iPTMnetiQ15424
PhosphoSitePlusiQ15424
SwissPalmiQ15424

Polymorphism and mutation databases

BioMutaiSAFB
DMDMi116242782

Proteomic databases

EPDiQ15424
jPOSTiQ15424
MassIVEiQ15424
MaxQBiQ15424
PaxDbiQ15424
PeptideAtlasiQ15424
PRIDEiQ15424
ProteomicsDBi25341
60586 [Q15424-1]

Genome annotation databases

EnsembliENST00000292123; ENSP00000292123; ENSG00000160633 [Q15424-1]
ENST00000454510; ENSP00000415895; ENSG00000160633 [Q15424-2]
ENST00000588852; ENSP00000467423; ENSG00000160633 [Q15424-3]
ENST00000592224; ENSP00000464840; ENSG00000160633 [Q15424-4]
GeneIDi6294
KEGGihsa:6294
UCSCiuc002mce.5 human [Q15424-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6294
DisGeNETi6294

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SAFB
HGNCiHGNC:10520 SAFB
HPAiCAB001969
HPA016832
HPA020076
MIMi602895 gene
neXtProtiNX_Q15424
OpenTargetsiENSG00000160633
PharmGKBiPA34928

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4661 Eukaryota
ENOG4111F1G LUCA
GeneTreeiENSGT00940000155916
HOGENOMiHOG000092533
InParanoidiQ15424
OMAiPRDRRDW
OrthoDBi803886at2759
PhylomeDBiQ15424
TreeFamiTF325240

Enzyme and pathway databases

ReactomeiR-HSA-3899300 SUMOylation of transcription cofactors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SAFB human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SAFB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6294
PharosiQ15424

Protein Ontology

More...
PROi
PR:Q15424

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160633 Expressed in 232 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ15424 baseline and differential
GenevisibleiQ15424 HS

Family and domain databases

Gene3Di1.10.720.30, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034781 SAFB1
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PANTHERiPTHR15683:SF6 PTHR15683:SF6, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00513 SAP, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50800 SAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAFB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15424
Secondary accession number(s): A0AV56
, B7Z5B6, B7ZLP6, F5H0H3, O60406, Q59HH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 187 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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