UniProtKB - Q15418 (KS6A1_HUMAN)
Ribosomal protein S6 kinase alpha-1
RPS6KA1
Functioni
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity).
Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).
By similarity12 Publications(Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated.
1 PublicationCatalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 94 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 187 | Proton acceptorBy similarity | 1 | |
Binding sitei | 447 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 535 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 68 – 76 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 424 – 432 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
- magnesium ion binding Source: InterPro
- protein serine/threonine/tyrosine kinase activity Source: MGI
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- ribosomal protein S6 kinase activity Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- chemical synaptic transmission Source: Reactome
- hepatocyte proliferation Source: UniProtKB
- intracellular signal transduction Source: InterPro
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of cell differentiation Source: UniProtKB
- positive regulation of cell growth Source: UniProtKB
- positive regulation of hepatic stellate cell activation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of DNA-templated transcription in response to stress Source: UniProtKB
- regulation of translation in response to stress Source: UniProtKB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Host-virus interaction, Stress response |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q15418 |
Reactomei | R-HSA-198753, ERK/MAPK targets R-HSA-199920, CREB phosphorylation R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-437239, Recycling pathway of L1 R-HSA-442742, CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-444257, RSK activation R-HSA-881907, Gastrin-CREB signalling pathway via PKC and MAPK |
SABIO-RKi | Q15418 |
SignaLinki | Q15418 |
SIGNORi | Q15418 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosomal protein S6 kinase alpha-1 (EC:2.7.11.1)Short name: S6K-alpha-1 Alternative name(s): 90 kDa ribosomal protein S6 kinase 1 Short name: p90-RSK 1 Short name: p90RSK1 Short name: p90S6K MAP kinase-activated protein kinase 1a Short name: MAPK-activated protein kinase 1a Short name: MAPKAP kinase 1a Short name: MAPKAPK-1a Ribosomal S6 kinase 1 Short name: RSK-1 |
Gene namesi | Name:RPS6KA1 Synonyms:MAPKAPK1A, RSK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10430, RPS6KA1 |
MIMi | 601684, gene |
neXtProti | NX_Q15418 |
VEuPathDBi | HostDB:ENSG00000117676 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6195 |
OpenTargetsi | ENSG00000117676 |
PharmGKBi | PA34845 |
Miscellaneous databases
Pharosi | Q15418, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2553 |
DrugBanki | DB12010, Fostamatinib DB04751, Purvalanol A |
DrugCentrali | Q15418 |
GuidetoPHARMACOLOGYi | 1527 |
Genetic variation databases
BioMutai | RPS6KA1 |
DMDMi | 20178306 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086198 | 1 – 735 | Ribosomal protein S6 kinase alpha-1Add BLAST | 735 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 54 | PhosphoserineCombined sources | 1 | |
Modified residuei | 221 | Phosphoserine; by PDPK11 Publication | 1 | |
Modified residuei | 307 | PhosphoserineCombined sources | 1 | |
Modified residuei | 359 | PhosphothreonineCombined sources1 Publication | 1 | |
Modified residuei | 363 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 369 | PhosphoserineCombined sources | 1 | |
Modified residuei | 380 | Phosphoserine; by autocatalysisCombined sources1 Publication | 1 | |
Modified residuei | 573 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 732 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15418 |
jPOSTi | Q15418 |
MassIVEi | Q15418 |
MaxQBi | Q15418 |
PaxDbi | Q15418 |
PeptideAtlasi | Q15418 |
PRIDEi | Q15418 |
ProteomicsDBi | 23324 60583 [Q15418-1] 60584 [Q15418-2] 60585 [Q15418-3] |
2D gel databases
UCD-2DPAGEi | Q15418 |
PTM databases
GlyGeni | Q15418, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15418 |
PhosphoSitePlusi | Q15418 |
Expressioni
Gene expression databases
Bgeei | ENSG00000117676, Expressed in blood and 205 other tissues |
ExpressionAtlasi | Q15418, baseline and differential |
Genevisiblei | Q15418, HS |
Organism-specific databases
HPAi | ENSG00000117676, Low tissue specificity |
Interactioni
Subunit structurei
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation.
Interacts with ETV1/ER81 and FGFR1.
5 Publications(Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus/HHV-8 protein ORF45; this interaction allows RPS6KA1 activation.
1 PublicationBinary interactionsi
Q15418
Protein-protein interaction databases
BioGRIDi | 112109, 169 interactors |
DIPi | DIP-29987N |
ELMi | Q15418 |
IntActi | Q15418, 56 interactors |
MINTi | Q15418 |
STRINGi | 9606.ENSP00000435412 |
Chemistry databases
BindingDBi | Q15418 |
Miscellaneous databases
RNActi | Q15418, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q15418 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15418 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 321 | Protein kinase 1PROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 322 – 391 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 70 | |
Domaini | 418 – 675 | Protein kinase 2PROSITE-ProRule annotationAdd BLAST | 258 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0603, Eukaryota |
GeneTreei | ENSGT00940000159314 |
HOGENOMi | CLU_000288_58_0_1 |
InParanoidi | Q15418 |
OMAi | ILEHSWV |
OrthoDBi | 1132245at2759 |
PhylomeDBi | Q15418 |
TreeFami | TF313438 |
Family and domain databases
CDDi | cd05582, STKc_RSK_N, 1 hit |
DisProti | DP01508 |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016239, Ribosomal_S6_kinase_II IPR041906, RSK_N IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 2 hits PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000606, Ribsml_S6_kin_2, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 2 hits |
SUPFAMi | SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 2 hits PS50011, PROTEIN_KINASE_DOM, 2 hits PS00108, PROTEIN_KINASE_ST, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPLAQLKEPW PLMELVPLDP ENGQTSGEEA GLQPSKDEGV LKEISITHHV
60 70 80 90 100
KAGSEKADPS HFELLKVLGQ GSFGKVFLVR KVTRPDSGHL YAMKVLKKAT
110 120 130 140 150
LKVRDRVRTK MERDILADVN HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF
160 170 180 190 200
TRLSKEVMFT EEDVKFYLAE LALGLDHLHS LGIIYRDLKP ENILLDEEGH
210 220 230 240 250
IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHS HSADWWSYGV
260 270 280 290 300
LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN
310 320 330 340 350
PANRLGSGPD GAEEIKRHVF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY
360 370 380 390 400
FDTEFTSRTP KDSPGIPPSA GAHQLFRGFS FVATGLMEDD GKPRAPQAPL
410 420 430 440 450
HSVVQQLHGK NLVFSDGYVV KETIGVGSYS ECKRCVHKAT NMEYAVKVID
460 470 480 490 500
KSKRDPSEEI EILLRYGQHP NIITLKDVYD DGKHVYLVTE LMRGGELLDK
510 520 530 540 550
ILRQKFFSER EASFVLHTIG KTVEYLHSQG VVHRDLKPSN ILYVDESGNP
560 570 580 590 600
ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL
610 620 630 640 650
GILLYTMLAG YTPFANGPSD TPEEILTRIG SGKFTLSGGN WNTVSETAKD
660 670 680 690 700
LVSKMLHVDP HQRLTAKQVL QHPWVTQKDK LPQSQLSHQD LQLVKGAMAA
710 720 730
TYSALNSSKP TPQLKPIESS ILAQRRVRKL PSTTL
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PGT3 | E9PGT3_HUMAN | Ribosomal protein S6 kinase | RPS6KA1 | 724 | Annotation score: | ||
Q5SVM7 | Q5SVM7_HUMAN | Ribosomal protein S6 kinase alpha-1 | RPS6KA1 | 115 | Annotation score: | ||
Q5SVM6 | Q5SVM6_HUMAN | Ribosomal protein S6 kinase alpha-1 | RPS6KA1 | 166 | Annotation score: | ||
E9PAN7 | E9PAN7_HUMAN | Ribosomal protein S6 kinase alpha-1 | RPS6KA1 | 204 | Annotation score: | ||
E9PMM7 | E9PMM7_HUMAN | Ribosomal protein S6 kinase alpha-1 | RPS6KA1 | 112 | Annotation score: | ||
E9PPN6 | E9PPN6_HUMAN | Ribosomal protein S6 kinase alpha-1 | RPS6KA1 | 52 | Annotation score: | ||
A6NND1 | A6NND1_HUMAN | Ribosomal protein S6 kinase alpha-1 | RPS6KA1 | 111 | Annotation score: | ||
E9PPC1 | E9PPC1_HUMAN | Ribosomal protein S6 kinase alpha-1 | RPS6KA1 | 56 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 609 | A → T in BAF85411 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 619 | S → G in BAF85411 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021864 | 335 | K → T2 PublicationsCorresponds to variant dbSNP:rs2229712Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041580 | 1 – 92 | Missing in isoform 3. 1 PublicationAdd BLAST | 92 | |
Alternative sequenceiVSP_041380 | 1 – 36 | MPLAQ…LQPSK → MEQDPKPPRLRLWALIPWLP RKQRPRISQTSLPVPGPGSG PQRDS in isoform 2. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_057469 | 1 – 35 | MPLAQ…GLQPS → MQTPADFPRVERDLVPCPR in isoform 4. Add BLAST | 35 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07597 mRNA Translation: AAC82497.1 AK292722 mRNA Translation: BAF85411.1 AK299007 mRNA Translation: BAH12926.1 AK315730 mRNA Translation: BAG38085.1 AL109743 Genomic DNA Translation: CAC36348.1 AL627313 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07799.1 BC014966 mRNA Translation: AAH14966.1 |
CCDSi | CCDS284.1 [Q15418-1] CCDS30649.1 [Q15418-2] CCDS81286.1 [Q15418-4] |
PIRi | I51901 |
RefSeqi | NP_001006666.1, NM_001006665.1 [Q15418-2] NP_001317370.1, NM_001330441.1 [Q15418-4] NP_002944.2, NM_002953.3 [Q15418-1] |
Genome annotation databases
Ensembli | ENST00000374168; ENSP00000363283; ENSG00000117676 ENST00000526792; ENSP00000431651; ENSG00000117676 [Q15418-3] ENST00000530003; ENSP00000432281; ENSG00000117676 [Q15418-4] ENST00000531382; ENSP00000435412; ENSG00000117676 [Q15418-2] ENST00000628081; ENSP00000487553; ENSG00000281877 [Q15418-4] ENST00000628256; ENSP00000487349; ENSG00000281877 [Q15418-2] ENST00000629832; ENSP00000486881; ENSG00000281877 ENST00000631108; ENSP00000487166; ENSG00000281877 [Q15418-3] |
GeneIDi | 6195 |
KEGGi | hsa:6195 |
MANE-Selecti | ENST00000374168.7; ENSP00000363283.2; NM_002953.4; NP_002944.2 |
UCSCi | uc001bmr.2, human [Q15418-1] uc057dso.1, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07597 mRNA Translation: AAC82497.1 AK292722 mRNA Translation: BAF85411.1 AK299007 mRNA Translation: BAH12926.1 AK315730 mRNA Translation: BAG38085.1 AL109743 Genomic DNA Translation: CAC36348.1 AL627313 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07799.1 BC014966 mRNA Translation: AAH14966.1 |
CCDSi | CCDS284.1 [Q15418-1] CCDS30649.1 [Q15418-2] CCDS81286.1 [Q15418-4] |
PIRi | I51901 |
RefSeqi | NP_001006666.1, NM_001006665.1 [Q15418-2] NP_001317370.1, NM_001330441.1 [Q15418-4] NP_002944.2, NM_002953.3 [Q15418-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2WNT | X-ray | 2.40 | A/B | 413-719 | [»] | |
2Z7Q | X-ray | 2.00 | A | 33-353 | [»] | |
2Z7R | X-ray | 2.00 | A | 33-353 | [»] | |
2Z7S | X-ray | 2.10 | A | 33-353 | [»] | |
3RNY | X-ray | 2.70 | A/B | 411-735 | [»] | |
3TEI | X-ray | 2.40 | B | 712-735 | [»] | |
4H3P | X-ray | 2.30 | B/E | 712-735 | [»] | |
4NIF | X-ray | 2.15 | A/D | 411-735 | [»] | |
5CSF | X-ray | 2.40 | C | 683-735 | [»] | |
5CSI | X-ray | 2.13 | C | 689-735 | [»] | |
5CSJ | X-ray | 2.70 | C | 696-735 | [»] | |
5CSN | X-ray | 2.95 | C | 683-720 | [»] | |
5N7D | X-ray | 2.30 | C | 688-735 | [»] | |
5N7F | X-ray | 2.30 | C | 688-735 | [»] | |
5N7G | X-ray | 2.95 | C | 729-735 | [»] | |
5V61 | X-ray | 2.20 | I | 713-729 | [»] | |
5V62 | X-ray | 1.90 | I | 713-729 | [»] | |
6TWY | X-ray | 2.30 | C | 725-735 | [»] | |
SMRi | Q15418 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112109, 169 interactors |
DIPi | DIP-29987N |
ELMi | Q15418 |
IntActi | Q15418, 56 interactors |
MINTi | Q15418 |
STRINGi | 9606.ENSP00000435412 |
Chemistry databases
BindingDBi | Q15418 |
ChEMBLi | CHEMBL2553 |
DrugBanki | DB12010, Fostamatinib DB04751, Purvalanol A |
DrugCentrali | Q15418 |
GuidetoPHARMACOLOGYi | 1527 |
PTM databases
GlyGeni | Q15418, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15418 |
PhosphoSitePlusi | Q15418 |
Genetic variation databases
BioMutai | RPS6KA1 |
DMDMi | 20178306 |
2D gel databases
UCD-2DPAGEi | Q15418 |
Proteomic databases
EPDi | Q15418 |
jPOSTi | Q15418 |
MassIVEi | Q15418 |
MaxQBi | Q15418 |
PaxDbi | Q15418 |
PeptideAtlasi | Q15418 |
PRIDEi | Q15418 |
ProteomicsDBi | 23324 60583 [Q15418-1] 60584 [Q15418-2] 60585 [Q15418-3] |
Protocols and materials databases
Antibodypediai | 2073, 1678 antibodies from 45 providers |
DNASUi | 6195 |
Genome annotation databases
Ensembli | ENST00000374168; ENSP00000363283; ENSG00000117676 ENST00000526792; ENSP00000431651; ENSG00000117676 [Q15418-3] ENST00000530003; ENSP00000432281; ENSG00000117676 [Q15418-4] ENST00000531382; ENSP00000435412; ENSG00000117676 [Q15418-2] ENST00000628081; ENSP00000487553; ENSG00000281877 [Q15418-4] ENST00000628256; ENSP00000487349; ENSG00000281877 [Q15418-2] ENST00000629832; ENSP00000486881; ENSG00000281877 ENST00000631108; ENSP00000487166; ENSG00000281877 [Q15418-3] |
GeneIDi | 6195 |
KEGGi | hsa:6195 |
MANE-Selecti | ENST00000374168.7; ENSP00000363283.2; NM_002953.4; NP_002944.2 |
UCSCi | uc001bmr.2, human [Q15418-1] uc057dso.1, human |
Organism-specific databases
CTDi | 6195 |
DisGeNETi | 6195 |
GeneCardsi | RPS6KA1 |
HGNCi | HGNC:10430, RPS6KA1 |
HPAi | ENSG00000117676, Low tissue specificity |
MIMi | 601684, gene |
neXtProti | NX_Q15418 |
OpenTargetsi | ENSG00000117676 |
PharmGKBi | PA34845 |
VEuPathDBi | HostDB:ENSG00000117676 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0603, Eukaryota |
GeneTreei | ENSGT00940000159314 |
HOGENOMi | CLU_000288_58_0_1 |
InParanoidi | Q15418 |
OMAi | ILEHSWV |
OrthoDBi | 1132245at2759 |
PhylomeDBi | Q15418 |
TreeFami | TF313438 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q15418 |
Reactomei | R-HSA-198753, ERK/MAPK targets R-HSA-199920, CREB phosphorylation R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-437239, Recycling pathway of L1 R-HSA-442742, CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-444257, RSK activation R-HSA-881907, Gastrin-CREB signalling pathway via PKC and MAPK |
SABIO-RKi | Q15418 |
SignaLinki | Q15418 |
SIGNORi | Q15418 |
Miscellaneous databases
BioGRID-ORCSi | 6195, 21 hits in 1078 CRISPR screens |
ChiTaRSi | RPS6KA1, human |
EvolutionaryTracei | Q15418 |
GeneWikii | RPS6KA1 |
GenomeRNAii | 6195 |
Pharosi | Q15418, Tchem |
PROi | PR:Q15418 |
RNActi | Q15418, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000117676, Expressed in blood and 205 other tissues |
ExpressionAtlasi | Q15418, baseline and differential |
Genevisiblei | Q15418, HS |
Family and domain databases
CDDi | cd05582, STKc_RSK_N, 1 hit |
DisProti | DP01508 |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016239, Ribosomal_S6_kinase_II IPR041906, RSK_N IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 2 hits PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000606, Ribsml_S6_kin_2, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 2 hits |
SUPFAMi | SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 2 hits PS50011, PROTEIN_KINASE_DOM, 2 hits PS00108, PROTEIN_KINASE_ST, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KS6A1_HUMAN | |
Accessioni | Q15418Primary (citable) accession number: Q15418 Secondary accession number(s): A6NGG4 Q9BQK2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | April 16, 2002 | |
Last modified: | February 23, 2022 | |
This is version 221 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families